                         SEQUENCE LISTING

<110>  INSERM
       UNIVERSITE DE LILLE 2
       UNIVERSITE PARIS SUD
       CHRU DE LILLE
 
<120>  ANTIBODIES FOR THE PREVENTION OR THE TREATMENT OF BLEEDING 
       EPISODES

<130>  13050LENTING/AS

<150>  EP 14 305 569.7
<151>  2014-04-16

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide covering residues 2158-2169 of VWF

<400>  1

Thr Phe Tyr Ala Ile Cys Gln Gln Asp Ser Cys His 
1               5                   10          


<210>  2
<211>  455
<212>  PRT
<213>  Artificial

<220>
<223>  mAb508 VH

<400>  2

Met Arg Val Leu Ile Leu Leu Cys Leu Phe Thr Ala Phe Pro Gly Leu 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Glu Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Ser Cys Thr Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Gly Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Leu Gly Tyr Ile His Tyr Ser Gly Thr Thr Thr Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu His Ser Arg Val Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Gln Leu Asn Ser Val Ser Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Phe Cys Gly Arg Glu Gly Tyr His Trp Gly Gln Gly Thr Thr Leu Thr 
        115                 120                 125             


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
    130                 135                 140                 


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
                165                 170                 175     


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
            180                 185                 190         


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
        195                 200                 205             


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys 
225                 230                 235                 240 


Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp 
        275                 280                 285             


Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys 
            340                 345                 350         


Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys 
        355                 360                 365             


Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp 
    370                 375                 380                 


Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys 
385                 390                 395                 400 


Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser 
                405                 410                 415     


Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr 
            420                 425                 430         


Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  3
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  mAb508 H-CDR1

<400>  3

Gly Tyr Ser Ile Thr Ser Gly Tyr Ser Trp His 
1               5                   10      


<210>  4
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  mAb508 H-CDR2

<400>  4

Tyr Ile His Tyr Ser Gly Thr Thr Thr Tyr Asn Pro Ser Leu His Ser 
1               5                   10                  15      


<210>  5
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  mAb508 H-CDR3

<400>  5

Glu Gly Tyr His 
1               


<210>  6
<211>  238
<212>  PRT
<213>  Artificial

<220>
<223>  mAb 508 VL

<400>  6

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Gly 
1               5                   10                  15      


Ser Thr Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Ile Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Thr Thr His Val Pro Leu Thr Phe Gly Gly Gly Thr Arg Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  7
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  mAb508 L-CDR1

<400>  7

Arg Ser Ser Gln Ser Leu Val His Ser Ile Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  mAb L-CDR2

<400>  8

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  mAb508 L-CDR3

<400>  9

Ser Gln Thr Thr His Val Pro Leu Thr 
1               5                   


<210>  10
<211>  1368
<212>  DNA
<213>  Artificial

<220>
<223>  mAb508 VH

<400>  10
atgagagtgc tgattctctt gtgcctgttc acagcctttc ctggtctcct gtctgatgtg       60

cagcttcagg agtcaggacc tgacctggtg gaaccttctc agtcactttc actctcctgc      120

actgtcactg gctactccat caccagtggt tatagctggc actggattcg gcagtttcca      180

ggaaacaaac tggaatggct gggctacatt cactacagtg gcaccactac ctacaaccca      240

tctctccaca gtcgagtctc tatcactcga gacacgtcca agaaccagtt cttcctgcag      300

ttgaattctg tgtctactga ggacacggcc acatatttct gtggaagaga aggttaccat      360

tggggccaag gcaccactct cacagtctcc tcagccaaaa cgacaccccc atctgtctat      420

ccactggccc ctggatctgc tgcccaaact aactccatgg tgaccctggg atgcctggtc      480

aagggctatt tccctgagcc agtgacagtg acctggaact ctggatccct gtccagcggt      540

gtgcacacct tcccagctgt cctgcagtct gacctctaca ctctgagcag ctcagtgact      600

gtcccctcca gcacctggcc cagcgagacc gtcacctgca acgttgccca cccggccagc      660

agcaccaagg tggacaagaa aattgtgccc agggattgtg gttgtaagcc ttgcatatgt      720

acagtcccag aagtatcatc tgtcttcatc ttccccccaa agcccaagga tgtgctcacc      780

attactctga ctcctaaggt cacgtgtgtt gtggtagaca tcagcaagga tgatcccgag      840

gtccagttca gctggtttgt agatgatgtg gaggtgcaca cagctcagac gcaaccccgg      900

gaggagcagt tcaacagcac tttccgctca gtcagtgaac ttcccatcat gcaccaggac      960

tggctcaatg gcaaggagtt caaatgcagg gtcaacagtg cagctttccc tgcccccatc     1020

gagaaaacca tctccaaaac caaaggcaga ccgaaggctc cacaggtgta caccattcca     1080

cctcccaagg agcagatggc caaggataaa gtcagtctga cctgcatgat aacagacttc     1140

ttccctgaag acattactgt ggagtggcag tggaatgggc agccagcgga gaactacaag     1200

aacactcagc ccatcatgga cacagatggc tcttacttcg tctacagcaa gctcaatgtg     1260

cagaagagca actgggaggc aggaaatact ttcacctgct ctgtgttaca tgagggcctg     1320

cacaaccacc atactgagaa gagcctctcc cactctcctg gtaaatga                  1368


<210>  11
<211>  717
<212>  DNA
<213>  Artificial

<220>
<223>  mAb508 VL

<400>  11
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctggttc caccagtgat       60

gttgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag tcttgtacac agcattggaa acacctattt acattggtac      180

ctgcagaagc caggccagtc tccaaaactc ctgatctaca aagtctccaa tcgattttct      240

ggggtcccag acagattcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat ttctgctctc aaactacaca tgttcctctg      360

acgttcggtg gaggcaccag gttggaaatc aaacgggctg atgctgcacc aactgtatcc      420

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg      480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa      540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc      600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc      660

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgttag         717


