                               SEQUENCE LISTING

<110> BROWN UNIVERSITY
 
<120> METHODS FOR THE DIAGNOSIS AND TREATMENT OF PULMONARY FIBROSIS IN 
      SUBJECTS WITH HERMANSKY PUDLAK SYNDROME

<130> 058040-080672-PCT

<140>
<141>

<150> 62/081,701
<151> 2014-11-19

<150> 61/984,253
<151> 2014-04-25

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 1376
<212> DNA
<213> Homo sapiens

<400> 1
gtaagaacac tctcgtgagt ctaacggtct tccggatgaa ggctatttga agtcgccata       60

acctggtcag aagtgtgcct gtcggcgggg agagaggcaa tatcaaggtt ttaaatctcg      120

gagaaatggc tttcgtttgc ttggctatcg gatgcttata tacctttctg ataagcacaa      180

catttggctg tacttcatct tcagacaccg agataaaagt taaccctcct caggattttg      240

agatagtgga tcccggatac ttaggttatc tctatttgca atggcaaccc ccactgtctc      300

tggatcattt taaggaatgc acagtggaat atgaactaaa ataccgaaac attggtagtg      360

aaacatggaa gaccatcatt actaagaatc tacattacaa agatgggttt gatcttaaca      420

agggcattga agcgaagata cacacgcttt taccatggca atgcacaaat ggatcagaag      480

ttcaaagttc ctgggcagaa actacttatt ggatatcacc acaaggaatt ccagaaacta      540

aagttcagga tatggattgc gtatattaca attggcaata tttactctgt tcttggaaac      600

ctggcatagg tgtacttctt gataccaatt acaacttgtt ttactggtat gagggcttgg      660

atcatgcatt acagtgtgtt gattacatca aggctgatgg acaaaatata ggatgcagat      720

ttccctattt ggaggcatca gactataaag atttctatat ttgtgttaat ggatcatcag      780

agaacaagcc tatcagatcc agttatttca cttttcagct tcaaaatata gttaaacctt      840

tgccgccagt ctatcttact tttactcggg agagttcatg tgaaattaag ctgaaatgga      900

gcataccttt gggacctatt ccagcaaggt gttttgatta tgaaattgag atcagagaag      960

atgatactac cttggtgact gctacagttg aaaatgaaac atacaccttg aaaacaacaa     1020

atgaaacccg acaattatgc tttgtagtaa gaagcaaagt gaatatttat tgctcagatg     1080

acggaatttg gagtgagtgg agtgataaac aatgctggga aggtgaagac ctatcgaaga     1140

aaactttgct acgtttctgg ctaccatttg gtttcatctt aatattagtt atatttgtaa     1200

ccggtctgct tttgcgtaag ccaaacacct acccaaaaat gattccagaa tttttctgtg     1260

atacatgaag actttccata tcaagagaca tggtattgac tcaacagttt ccagtcatgg     1320

ccaaatgttc aatatgagtc tcaataaact gaatttttct tgcgaatgtt gaaaaa         1376


<210> 2
<211> 380
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Phe Val Cys Leu Ala Ile Gly Cys Leu Tyr Thr Phe Leu Ile 
1               5                   10                  15      


Ser Thr Thr Phe Gly Cys Thr Ser Ser Ser Asp Thr Glu Ile Lys Val 
            20                  25                  30          


Asn Pro Pro Gln Asp Phe Glu Ile Val Asp Pro Gly Tyr Leu Gly Tyr 
        35                  40                  45              


Leu Tyr Leu Gln Trp Gln Pro Pro Leu Ser Leu Asp His Phe Lys Glu 
    50                  55                  60                  


Cys Thr Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 
65                  70                  75                  80  


Trp Lys Thr Ile Ile Thr Lys Asn Leu His Tyr Lys Asp Gly Phe Asp 
                85                  90                  95      


Leu Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu Pro Trp Gln 
            100                 105                 110         


Cys Thr Asn Gly Ser Glu Val Gln Ser Ser Trp Ala Glu Thr Thr Tyr 
        115                 120                 125             


Trp Ile Ser Pro Gln Gly Ile Pro Glu Thr Lys Val Gln Asp Met Asp 
    130                 135                 140                 


Cys Val Tyr Tyr Asn Trp Gln Tyr Leu Leu Cys Ser Trp Lys Pro Gly 
145                 150                 155                 160 


Ile Gly Val Leu Leu Asp Thr Asn Tyr Asn Leu Phe Tyr Trp Tyr Glu 
                165                 170                 175     


Gly Leu Asp His Ala Leu Gln Cys Val Asp Tyr Ile Lys Ala Asp Gly 
            180                 185                 190         


Gln Asn Ile Gly Cys Arg Phe Pro Tyr Leu Glu Ala Ser Asp Tyr Lys 
        195                 200                 205             


Asp Phe Tyr Ile Cys Val Asn Gly Ser Ser Glu Asn Lys Pro Ile Arg 
    210                 215                 220                 


Ser Ser Tyr Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro 
225                 230                 235                 240 


Pro Val Tyr Leu Thr Phe Thr Arg Glu Ser Ser Cys Glu Ile Lys Leu 
                245                 250                 255     


Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg Cys Phe Asp Tyr 
            260                 265                 270         


Glu Ile Glu Ile Arg Glu Asp Asp Thr Thr Leu Val Thr Ala Thr Val 
        275                 280                 285             


Glu Asn Glu Thr Tyr Thr Leu Lys Thr Thr Asn Glu Thr Arg Gln Leu 
    290                 295                 300                 


Cys Phe Val Val Arg Ser Lys Val Asn Ile Tyr Cys Ser Asp Asp Gly 
305                 310                 315                 320 


Ile Trp Ser Glu Trp Ser Asp Lys Gln Cys Trp Glu Gly Glu Asp Leu 
                325                 330                 335     


Ser Lys Lys Thr Leu Leu Arg Phe Trp Leu Pro Phe Gly Phe Ile Leu 
            340                 345                 350         


Ile Leu Val Ile Phe Val Thr Gly Leu Leu Leu Arg Lys Pro Asn Thr 
        355                 360                 365             


Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys Asp Thr 
    370                 375                 380 


<210> 3
<211> 2910
<212> DNA
<213> Homo sapiens

<400> 3
cagcctccct ctcccacctc tgtctgcccg ctgcctcttg tctagctgct gtcaggagct       60

gactgcctcc agggctggaa tcctgtgctc cctctgtgcc cagagcccca cgatgtcggc      120

caacgccaca ctgaagccac tctgccccat cctggagcag atgagccgtc tccagagcca      180

cagcaacacc agcatccgct acatcgacca cgcggccgtg ctgctgcacg ggctggcctc      240

gctgctgggc ctggtggaga atggagtcat cctcttcgtg gtgggctgcc gcatgcgcca      300

gaccgtggtc accacctggg tgctgcacct ggcgctgtcc gacctgttgg cctctgcttc      360

cctgcccttc ttcacctact tcttggccgt gggccactcg tgggagctgg gcaccacctt      420

ctgcaaactg cactcctcca tcttctttct caacatgttc gccagcggct tcctgctcag      480

cgccatcagc ctggaccgct gcctgcaggt ggtgcggccg gtgtgggcgc agaaccaccg      540

caccgtggcc gcggcgcaca aagtctgcct ggtgctttgg gcactagcgg tgctcaacac      600

ggtgccctat ttcgtgttcc gggacaccat ctcgcggctg gacgggcgca ttatgtgcta      660

ctacaatgtg ctgctcctga acccggggcc tgaccgcgat gccacgtgca actcgcggca      720

ggtggccctg gccgtcagca agttcctgct ggccttcctg gtgccgctgg cgatcatcgc      780

ctcgagccac gcggccgtga gcctgcggtt gcagcaccgc ggccgccggc ggccaggccg      840

cttcgtgcgc ctggtggcgg ccgtcgtggc cgccttcgcg ctctgctggg ggccctacca      900

cgtgttcagc ctgctggagg cgcgggcgca cgcaaacccg gggctgcggc cgctcgtgtg      960

gcgcgggctg cccttcgtca ccagcctggc cttcttcaac agcgtggcca acccggtgct     1020

ctacgtgctc acctgccccg acatgctgcg caagctgcgg cgctcgctgc gcacggtgct     1080

ggagagcgtg ctggtggacg acagcgagct gggtggcgcg ggaagcagcc gccgccgccg     1140

cacctcctcc accgcccgct cggcctcccc tttagctctc tgcagccgcc cggaggaacc     1200

gcggggcccc gcgcgtctcc tcggctggct gctgggcagc tgcgcagcgt ccccgcagac     1260

gggccccctg aaccgggcgc tgagcagcac ctcgagttag aacccggccc acgtagggcg     1320

gcactcacac gcgaaagtat caccagggtg ccgcggttca attcgatatc cggactcctg     1380

ccgcagtgat caaagtccga ggggcgggac ccaggcacct gcattttaaa gcgccccggg     1440

agactctgaa tctttttcag aaacagtgag ttaaagcagt gcttctcaaa ccttgatgtg     1500

cctgtgaatc acctaggggt cttgttaagt gcagtctgat ccaggaggcc ggggccgggt     1560

actgagagtc tgcacttaac aagctcccag gccgagaagc cagtgcggca ggttcacagg     1620

cgaggcctgg agtaacacaa agtgaaactc ataatagact tcccactcta gggcagtgga     1680

gtcggaaggg cacacggggt gcgtctcccc ggagttcagt tttaccagat gatgggggag     1740

gggggaagga gttttatgtt aaaccatcca tgtatttttg gagaagagag aggaaaggtt     1800

tgagaagcac tgttccagcc tgccctcttc atttagccaa tgcttactgc gctagacgct     1860

tcatcccaca atcttaaggg gcagcttcta ttagccagtc tttacagctg agcacattct     1920

ggctcaggga ggttaagtga cttgcccagt ttcagggcta acgaccacag ggtctgcact     1980

ctaaccctag gcatcacatg ctcaatgact ctctggtgag cgaggacatt ctctgaccta     2040

ctcgagggac ttaagatgct accttgtgac ccagcactgc ccaaagtgct tccaaggcag     2100

aagcagcagg ggatggcgtg gtcaagcact cgggaaacct ggggctaatc aaatccaatg     2160

ggggaaatga ctaaaagtct tcggtcgtta gaagttgaat gggcacagca actctaagac     2220

tacagcacac gtcatttctt agctaagcgg accagcctcc ctgtcggcct ggtgttctgt     2280

gggatccctc tgggcactgg taatcccaag atctgtgcag ccccgcctcc aggccacatg     2340

gggctgggca gctaccattt cccttttgcg gatgggaggg gtaacttgca cctctgacct     2400

atcacttcca ctgcaccccg tctcattcct ccacctgccg tggacttggg gtcagagact     2460

gctgtgtttg agctctgcag cccagggacc gaaaagttgg tgtcaatgaa ttttgcttgg     2520

tggatgaaat gtcagtggaa gaagcagatg agaaactctt gagatcttgg tcctgtgttt     2580

tttctgccac caaaggccag ggtcactgaa ggcctggccc acagcaggtg ctgagcaaag     2640

ggaacagtga ggtgcccagc tagctgcaga gccaccctgt gttgacacct cgcccctgct     2700

ccctcccatc ccttccccct ttactcatag cacttccccc attggacacg tggtgcattt     2760

tgcttgttta ttatgttttc tctccatcag aatgaaagct cctcgagggc agggactttg     2820

gtctattgtc tgtatttgcc ggtgcctagg attgtgcctg tatgcaacag gcactcaata     2880

aatatttttg ctgtagactg gacaggcatg                                      2910


<210> 4
<211> 395
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Ala Asn Ala Thr Leu Lys Pro Leu Cys Pro Ile Leu Glu Gln 
1               5                   10                  15      


Met Ser Arg Leu Gln Ser His Ser Asn Thr Ser Ile Arg Tyr Ile Asp 
            20                  25                  30          


His Ala Ala Val Leu Leu His Gly Leu Ala Ser Leu Leu Gly Leu Val 
        35                  40                  45              


Glu Asn Gly Val Ile Leu Phe Val Val Gly Cys Arg Met Arg Gln Thr 
    50                  55                  60                  


Val Val Thr Thr Trp Val Leu His Leu Ala Leu Ser Asp Leu Leu Ala 
65                  70                  75                  80  


Ser Ala Ser Leu Pro Phe Phe Thr Tyr Phe Leu Ala Val Gly His Ser 
                85                  90                  95      


Trp Glu Leu Gly Thr Thr Phe Cys Lys Leu His Ser Ser Ile Phe Phe 
            100                 105                 110         


Leu Asn Met Phe Ala Ser Gly Phe Leu Leu Ser Ala Ile Ser Leu Asp 
        115                 120                 125             


Arg Cys Leu Gln Val Val Arg Pro Val Trp Ala Gln Asn His Arg Thr 
    130                 135                 140                 


Val Ala Ala Ala His Lys Val Cys Leu Val Leu Trp Ala Leu Ala Val 
145                 150                 155                 160 


Leu Asn Thr Val Pro Tyr Phe Val Phe Arg Asp Thr Ile Ser Arg Leu 
                165                 170                 175     


Asp Gly Arg Ile Met Cys Tyr Tyr Asn Val Leu Leu Leu Asn Pro Gly 
            180                 185                 190         


Pro Asp Arg Asp Ala Thr Cys Asn Ser Arg Gln Val Ala Leu Ala Val 
        195                 200                 205             


Ser Lys Phe Leu Leu Ala Phe Leu Val Pro Leu Ala Ile Ile Ala Ser 
    210                 215                 220                 


Ser His Ala Ala Val Ser Leu Arg Leu Gln His Arg Gly Arg Arg Arg 
225                 230                 235                 240 


Pro Gly Arg Phe Val Arg Leu Val Ala Ala Val Val Ala Ala Phe Ala 
                245                 250                 255     


Leu Cys Trp Gly Pro Tyr His Val Phe Ser Leu Leu Glu Ala Arg Ala 
            260                 265                 270         


His Ala Asn Pro Gly Leu Arg Pro Leu Val Trp Arg Gly Leu Pro Phe 
        275                 280                 285             


Val Thr Ser Leu Ala Phe Phe Asn Ser Val Ala Asn Pro Val Leu Tyr 
    290                 295                 300                 


Val Leu Thr Cys Pro Asp Met Leu Arg Lys Leu Arg Arg Ser Leu Arg 
305                 310                 315                 320 


Thr Val Leu Glu Ser Val Leu Val Asp Asp Ser Glu Leu Gly Gly Ala 
                325                 330                 335     


Gly Ser Ser Arg Arg Arg Arg Thr Ser Ser Thr Ala Arg Ser Ala Ser 
            340                 345                 350         


Pro Leu Ala Leu Cys Ser Arg Pro Glu Glu Pro Arg Gly Pro Ala Arg 
        355                 360                 365             


Leu Leu Gly Trp Leu Leu Gly Ser Cys Ala Ala Ser Pro Gln Thr Gly 
    370                 375                 380                 


Pro Leu Asn Arg Ala Leu Ser Ser Thr Ser Ser 
385                 390                 395 


<210> 5
<211> 1867
<212> DNA
<213> Homo sapiens

<400> 5
cacatagctc agttcccata aaagggctgg tttgccgcgt cggggagtgg agtgggacag       60

gtatataaag gaagtacagg gcctggggaa gaggccctgt ctaggtagct ggcaccagga      120

gccgtgggca agggaagagg ccacaccctg ccctgctctg ctgcagccag aatgggtgtg      180

aaggcgtctc aaacaggctt tgtggtcctg gtgctgctcc agtgctgctc tgcatacaaa      240

ctggtctgct actacaccag ctggtcccag taccgggaag gcgatgggag ctgcttccca      300

gatgcccttg accgcttcct ctgtacccac atcatctaca gctttgccaa tataagcaac      360

gatcacatcg acacctggga gtggaatgat gtgacgctct acggcatgct caacacactc      420

aagaacagga accccaacct gaagactctc ttgtctgtcg gaggatggaa ctttgggtct      480

caaagatttt ccaagatagc ctccaacacc cagagtcgcc ggactttcat caagtcagta      540

ccgccatttc tgcgcaccca tggctttgat gggctggacc ttgcctggct ctaccctgga      600

cggagagaca aacagcattt taccacccta atcaaggaaa tgaaggccga atttataaag      660

gaagcccagc cagggaaaaa gcagctcctg ctcagcgcag cactgtctgc ggggaaggtc      720

accattgaca gcagctatga cattgccaag atatcccaac acctggattt cattagcatc      780

atgacctacg attttcatgg agcctggcgt gggaccacag gccatcacag tcccctgttc      840

cgaggtcagg aggatgcaag tcctgacaga ttcagcaaca ctgactatgc tgtggggtac      900

atgttgaggc tgggggctcc tgccagtaag ctggtgatgg gcatccccac cttcgggagg      960

agcttcactc tggcttcttc tgagactggt gttggagccc caatctcagg accgggaatt     1020

ccaggccggt tcaccaagga ggcagggacc cttgcctact atgagatctg tgacttcctc     1080

cgcggagcca cagtccatag aatcctcggc cagcaggtcc cctatgccac caagggcaac     1140

cagtgggtag gatacgacga ccaggaaagc gtcaaaagca aggtgcagta cctgaaggac     1200

aggcagctgg cgggcgccat ggtatgggcc ctggacctgg atgacttcca gggctccttc     1260

tgcggccagg atctgcgctt ccctctcacc aatgccatca aggatgcact cgctgcaacg     1320

tagccctctg ttctgcacac agcacggggg ccaaggatgc cccgtccccc tctggctcca     1380

gctggccggg agcctgatca cctgccctgc tgagtcccag gctgagcctc agtctccctc     1440

ccttggggcc tatgcagagg tccacaacac acagatttga gctcagccct ggtgggcaga     1500

gaggtaggga tggggctgtg gggatagtga ggcatcgcaa tgtaagactc gggattagta     1560

cacacttgtt gattaatgga aatgtttaca gatccccaag cctggcaagg gaatttcttc     1620

aactccctgc cccccagccc tccttatcaa aggacaccat tttggcaagc tctatcacca     1680

aggagccaaa catcctacaa gacacagtga ccatactaat tataccccct gcaaagccca     1740

gcttgaaacc ttcacttagg aacgtaatcg tgtcccctat cctacttccc cttcctaatt     1800

ccacagctgc tcaataaagt acaagagctt aacagtgaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaa                                                               1867


<210> 6
<211> 383
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu 
1               5                   10                  15      


Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser 
            20                  25                  30          


Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 
        35                  40                  45              


Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 
    50                  55                  60                  


His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu 
65                  70                  75                  80  


Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn 
            100                 105                 110         


Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg 
        115                 120                 125             


Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg 
    130                 135                 140                 


Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu 
145                 150                 155                 160 


Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala 
                165                 170                 175     


Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala 
            180                 185                 190         


Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe 
        195                 200                 205             


His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg 
    210                 215                 220                 


Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met 
                245                 250                 255     


Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr 
            260                 265                 270         


Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr 
        275                 280                 285             


Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg 
    290                 295                 300                 


Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr 
305                 310                 315                 320 


Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser 
                325                 330                 335     


Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp 
            340                 345                 350         


Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu 
        355                 360                 365             


Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr 
    370                 375                 380             


<210> 7
<211> 1234
<212> DNA
<213> Homo sapiens

<400> 7
gggccgcgag cactggcggg ttctgggtcc tgtgaccggt caggcggcgt cagcgggcgc       60

ggcggagggc tggccggcct cgggggagtt tccgcggccg ccgggggcgc ggcggcagag      120

cgcgaggccg ggcagggggc cagactcgga gtcgaggcgc gcccgacagc cgcagcgctc      180

atggcgggcg gaggagccgg ggaccccggc ctgggggcgg ccgccgcccc agcgcccgag      240

acccgcgagc acctcttcaa ggtgctggtg atcggcgagc ttggcgtggg caagaccagc      300

atcatcaagc gctacgtcca ccagctcttc tcccagcact accgggccac catcggggtg      360

gacttcgccc tcaaggtcct caactgggac agcaggactc tggtgcgcct gcagctgtgg      420

gacatcgcgg ggcaggagcg atttggcaac atgacccgag tatactacaa ggaagctgtt      480

ggtgcttttg tagtctttga tatatcaaga agttccacat ttgaggcagt cttaaaatgg      540

aaaagtgatc tggatagtaa agttcatctt ccaaatggca gccctatccc tgctgtcctc      600

ttggctaaca aatgtgacca gaacaaggac agtagccaga gtccttccca ggtggaccaa      660

ttctgcaaag aacatggctt tgccggatgg tttgaaacct ctgcaaagga taacataaac      720

atagaggaag ctgcccggtt cctagtggag aagattcttg taaaccacca aagctttcct      780

aatgaagaaa acgatgtgga caaaattaag ctagatcaag agaccttgag agcagagaac      840

aaatcccagt gttgctgata tatggcttct gcttctcttg tgtgtgcctc agctctgaag      900

aagttcctga gaatgggtta cagatgtcat gttagctggg agtcttccca catgtggcac      960

ttcaaaaggc agcaccactg ggcgcctgca cttatttgaa aatggaactt tgggagaagt     1020

atccctgcta gtggctctgt aacttaacag atgacaatta ggcttttgtc attgttgcca     1080

tcatatggaa gataatgttt acatcctttt aaacattttt atatgacaat tcctcaggat     1140

ttggtaaggc ttccaagttg tagcttttag tgtaagtgct ggggtggtaa taaaatgtta     1200

cctgcaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                 1234


<210> 8
<211> 225
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Gly Gly Gly Ala Gly Asp Pro Gly Leu Gly Ala Ala Ala Ala 
1               5                   10                  15      


Pro Ala Pro Glu Thr Arg Glu His Leu Phe Lys Val Leu Val Ile Gly 
            20                  25                  30          


Glu Leu Gly Val Gly Lys Thr Ser Ile Ile Lys Arg Tyr Val His Gln 
        35                  40                  45              


Leu Phe Ser Gln His Tyr Arg Ala Thr Ile Gly Val Asp Phe Ala Leu 
    50                  55                  60                  


Lys Val Leu Asn Trp Asp Ser Arg Thr Leu Val Arg Leu Gln Leu Trp 
65                  70                  75                  80  


Asp Ile Ala Gly Gln Glu Arg Phe Gly Asn Met Thr Arg Val Tyr Tyr 
                85                  90                  95      


Lys Glu Ala Val Gly Ala Phe Val Val Phe Asp Ile Ser Arg Ser Ser 
            100                 105                 110         


Thr Phe Glu Ala Val Leu Lys Trp Lys Ser Asp Leu Asp Ser Lys Val 
        115                 120                 125             


His Leu Pro Asn Gly Ser Pro Ile Pro Ala Val Leu Leu Ala Asn Lys 
    130                 135                 140                 


Cys Asp Gln Asn Lys Asp Ser Ser Gln Ser Pro Ser Gln Val Asp Gln 
145                 150                 155                 160 


Phe Cys Lys Glu His Gly Phe Ala Gly Trp Phe Glu Thr Ser Ala Lys 
                165                 170                 175     


Asp Asn Ile Asn Ile Glu Glu Ala Ala Arg Phe Leu Val Glu Lys Ile 
            180                 185                 190         


Leu Val Asn His Gln Ser Phe Pro Asn Glu Glu Asn Asp Val Asp Lys 
        195                 200                 205             


Ile Lys Leu Asp Gln Glu Thr Leu Arg Ala Glu Asn Lys Ser Gln Cys 
    210                 215                 220                 


Cys 
225 


<210> 9
<211> 1479
<212> DNA
<213> Homo sapiens

<400> 9
ttgcgctccc caagtctctc tcgtgcgcag agcccaggct gcgcttccct ggtcaggcac       60

ggcacgtctg gccggccgcc aggatgcagg ccccgcacaa ggagcacctg tacaagttgc      120

tggtgattgg cgacctgggc gtggggaaga ccagtatcat caagcgctac gtgcaccaga      180

acttctcttc gcactaccgg gccacaatcg gcgtggactt cgcgctcaag gtgctccact      240

gggacccgga gactgtggtg cgcctgcagc tctgggatat cgcaggtcaa gaaagatttg      300

gaaacatgac gagggtctat taccgagaag ctatgggtgc atttattgtc ttcgatgtca      360

ccaggccagc cacatttgaa gcagtggcaa agtggaaaaa tgatttggac tccaagttaa      420

gtctccctaa tggcaaaccg gtttcagtgg ttttgttggc caacaaatgt gaccagggga      480

aggatgtgct catgaacaat ggcctcaaga tggaccagtt ctgcaaggag cacggtttcg      540

taggatggtt tgaaacatca gcaaaggaaa atataaacat tgatgaagcc tccagatgcc      600

tggtgaaaca catacttgca aatgagtgtg acctaatgga gtctattgag ccggacgtcg      660

tgaagcccca tctcacatca accaaggttg ccagctgctc tggctgtgcc aaatcctagt      720

aggcaccttt gctggtgtct ggtaggaatg acctcattgt tccacaaatt gtgcctctat      780

ttttaccatt ttgggtaaac gtcaggatag agataccaca tgtggcaagc caaagatcta      840

tgcctctgtt ttttcagtga gagagaaata gcaaatgttc tttctatgct ttcctcacca      900

tcatcacagt gtttacaaac ttttgaaaat atttagtctg ttacaaactt ctgtcatgta      960

gctgaccaaa atcctgcagg gccacagtcg gcactgttat ttgcttcttt taatcagcaa     1020

aggcctcaag tcttaaaata aaaggggaga agaacaaact agctgtcaag tcaaggactg     1080

gctttcacct tgccctggtg tctttttcca gatttcagta tattctctga tggcctgaca     1140

ggcctattaa gtagatgtga tattttctcc caagatgacc tccattctcg gcagacctaa     1200

gagttgcctc tgagttagct ctttggaatc gtgaacacag gtgtgctata ttgtccttgt     1260

cctaactgtc acttgccatg gcctgaatgt tggcttaact gaatattgta tgaaaagaca     1320

tgcctccata tgtgcctttc tgttagcttt ctctgactca agctgtgggg ctcctctata     1380

catgctatac atgtaatata tattatatat atttttgcaa gtgaacaata aaacattaaa     1440

agatgctgtt tccctattta aaaaaaaaaa aaaaaaaaa                            1479


<210> 10
<211> 211
<212> PRT
<213> Homo sapiens

<400> 10
Met Gln Ala Pro His Lys Glu His Leu Tyr Lys Leu Leu Val Ile Gly 
1               5                   10                  15      


Asp Leu Gly Val Gly Lys Thr Ser Ile Ile Lys Arg Tyr Val His Gln 
            20                  25                  30          


Asn Phe Ser Ser His Tyr Arg Ala Thr Ile Gly Val Asp Phe Ala Leu 
        35                  40                  45              


Lys Val Leu His Trp Asp Pro Glu Thr Val Val Arg Leu Gln Leu Trp 
    50                  55                  60                  


Asp Ile Ala Gly Gln Glu Arg Phe Gly Asn Met Thr Arg Val Tyr Tyr 
65                  70                  75                  80  


Arg Glu Ala Met Gly Ala Phe Ile Val Phe Asp Val Thr Arg Pro Ala 
                85                  90                  95      


Thr Phe Glu Ala Val Ala Lys Trp Lys Asn Asp Leu Asp Ser Lys Leu 
            100                 105                 110         


Ser Leu Pro Asn Gly Lys Pro Val Ser Val Val Leu Leu Ala Asn Lys 
        115                 120                 125             


Cys Asp Gln Gly Lys Asp Val Leu Met Asn Asn Gly Leu Lys Met Asp 
    130                 135                 140                 


Gln Phe Cys Lys Glu His Gly Phe Val Gly Trp Phe Glu Thr Ser Ala 
145                 150                 155                 160 


Lys Glu Asn Ile Asn Ile Asp Glu Ala Ser Arg Cys Leu Val Lys His 
                165                 170                 175     


Ile Leu Ala Asn Glu Cys Asp Leu Met Glu Ser Ile Glu Pro Asp Val 
            180                 185                 190         


Val Lys Pro His Leu Thr Ser Thr Lys Val Ala Ser Cys Ser Gly Cys 
        195                 200                 205             


Ala Lys Ser 
    210     


