                         SEQUENCE LISTING

<110>  bluebird bio Inc.
 
<120>  MND PROMOTER CHIMERIC ANTIGEN RECEPTORS

<130>  BLBD-027/01WO

<150>  US 61/984,561
<151>  2014-04-25

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide sequence the myeloproliferative sarcoma virus 
       enhancer, negative control region deleted, dl587rev 
       primer-binding site substituted (MND) promoter

<400>  1
tttatttagt ctccagaaaa aggggggaat gaaagacccc acctgtaggt ttggcaagct       60

aggatcaagg ttaggaacag agagacagca gaatatgggc caaacaggat atctgtggta      120

agcagttcct gccccggctc agggccaaga acagttggaa cagcagaata tgggccaaac      180

aggatatctg tggtaagcag ttcctgcccc ggctcagggc caagaacaga tggtccccag      240

atgcggtccc gccctcagca gtttctagag aaccatcaga tgtttccagg gtgccccaag      300

gacctgaaat gaccctgtgc cttatttgaa ctaaccaatc agttcgcttc tcgcttctgt      360

tcgcgcgctt ctgctccccg agctcaataa aagagccca                             399


<210>  2
<211>  7425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide sequence of a MND promoter anti-CD19 CAR construct

<400>  2
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatcatat gccagcctat ggtgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc ggttttggca      600

gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat      660

tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa aatgtcgtaa      720

caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag      780

cagagctcgt ttagtgaacc gggtctctct ggttagacca gatctgagcc tgggagctct      840

ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgctcaaag      900

tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt      960

cagtgtggaa aatctctagc agtggcgccc gaacagggac ttgaaagcga aagtaaagcc     1020

agaggagatc tctcgacgca ggactcggct tgctgaagcg cgcacggcaa gaggcgaggg     1080

gcggcgactg gtgagtacgc caaaaatttt gactagcgga ggctagaagg agagagtagg     1140

gtgcgagagc gtcggtatta agcgggggag aattagataa atgggaaaaa attcggttaa     1200

ggccaggggg aaagaaacaa tataaactaa aacatatagt tagggcaagc agggagctag     1260

aacgattcgc agttaatcct ggccttttag agacatcaga aggctgtaga caaatactgg     1320

gacagctaca accatccctt cagacaggat cagaagaact tagatcatta tataatacaa     1380

tagcagtcct ctattgtgtg catcaaagga tagatgtaaa agacaccaag gaagccttag     1440

ataagataga ggaagagcaa aacaaaagta agaaaaaggc acagcaagca gcagctgaca     1500

caggaaacaa cagccaggtc agccaaaatt accctatagt gcagaacctc caggggcaaa     1560

tggtacatca ggccatatca cctagaactt taaattaaga cagcagtaca aatggcagta     1620

ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg ggaaagaata     1680

gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat tacaaaaatt     1740

caaaattttc gggtttatta cagggacagc agagatccag tttggaaagg accagcaaag     1800

ctcctctgga aaggtgaagg ggcagtagta atacaagata atagtgacat aaaagtagtg     1860

ccaagaagaa aagcaaagat catcagggat tatggaaaac agatggcagg tgatgattgt     1920

gtggcaagta gacaggatga ggattaacac atggaaaaga ttagtaaaac accatagctc     1980

tagagcgatc ccgatcttca gacctggagg aggagatatg agggacaatt ggagaagtga     2040

attatataaa tataaagtag taaaaattga accattagga gtagcaccca ccaaggcaaa     2100

gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt tccttgggtt     2160

cttgggagca gcaggaagca ctatgggcgc agcgtcaatg acgctgacgg tacaggccag     2220

acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta ttgaggcgca     2280

acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa gaatcctggc     2340

tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct ctggaaaact     2400

catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc tggaacagat     2460

ttggaatcac acgacctgga tggagtggga cagagaaatt aacaattaca caagcttggt     2520

aggtttaaga atagtttttg ctgtactttc tatagtgaat agagttaggc agggatattc     2580

accattatcg tttcagaccc acctcccaac cccgagggga cccgacaggc ccgaaggaat     2640

agaagaagaa ggtggagaga gagacagaga cagatccatt cgattagtga acggatccat     2700

cgattagtcc aatttgttaa agacaggata tcagtggtcc aggctctagt tttgactcaa     2760

caatatcacc agctgaagcc tatagagtac gagccataga tagaataaaa gattttattt     2820

agtctccaga aaaagggggg aatgaaagac cccacctgta ggtttggcaa gctaggatca     2880

aggttaggaa cagagagaca gcagaatatg ggccaaacag gatatctgtg gtaagcagtt     2940

cctgccccgg ctcagggcca agaacagttg gaacagcaga atatgggcca aacaggatat     3000

ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggtccc cagatgcggt     3060

cccgccctca gcagtttcta gagaaccatc agatgtttcc agggtgcccc aaggacctga     3120

aatgaccctg tgccttattt gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg     3180

cttctgctcc ccgagctcaa taaaagagcc cacaacccct cactcggcgc gacgcgtcat     3240

agccaccatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc     3300

cgccaggccg gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga     3360

cagagtcacc atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca     3420

gcagaaacca gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg     3480

agtcccatca aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa     3540

cctggagcaa gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac     3600

gttcggaggg gggaccaagc tggagatcac aggtggcggt ggctccggcg gtggtgggtc     3660

tggtggcggc ggaagcgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc     3720

acagagcctg tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag     3780

ctggattcgc cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga     3840

aaccacatac tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa     3900

gagccaagtt ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg     3960

tgccaaacat tattactacg gtggtagcta tgctatggac tactggggtc aaggaacctc     4020

ggtcaccgtc tcctcaacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat     4080

cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt     4140

gcacacgagg gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac     4200

ttgtggggtc cttctcctgt cactggtgat caccctttac tgcaaacggg gcagaaagaa     4260

actcctgtat atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga     4320

tggctgtagc tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt     4380

cagcaggagc gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct     4440

caatctagga cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga     4500

gatgggggga aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa     4560

agataagatg gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa     4620

ggggcacgat ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct     4680

tcacatgcag gccctgcccc ctcgctaatg acaggtacct ttaagaccaa tgacttacaa     4740

ggcagctgta gatcttagcc actttttaaa agaaaagggg ggactggaag ggctaattca     4800

ctcccaaaga agacaagatc tgctttttgc ctgtactggg tctctctggt tagaccagat     4860

ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc aataaagctt     4920

gccttgagtg cttcaatgtg tgtgttggtt ttttgtgtgt cgaaattcta gcgattctag     4980

cttggcgtac cagcctatgg cgctcacaat tccacacaac atacgagccg gaagcataaa     5040

gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact     5100

gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc     5160

ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg     5220

ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc     5280

cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag     5340

gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca     5400

tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca     5460

ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg     5520

atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag     5580

gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt     5640

tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca     5700

cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg     5760

cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt     5820

tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc     5880

cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg     5940

cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg     6000

gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta     6060

gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg     6120

gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg     6180

ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc     6240

atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc     6300

agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc     6360

ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag     6420

tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat     6480

ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg     6540

caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt     6600

gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag     6660

atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg     6720

accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt     6780

aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct     6840

gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac     6900

tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat     6960

aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat     7020

ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca     7080

aataggggtt ccgcgcacat ttccccgaaa agtgccacct gggactagct ttttgcaaaa     7140

gcctaggcct ccaaaaaagc ctcctcacta cttctggaat agctcagagg ccgaggcggc     7200

ctcggcctct gcataaataa aaaaaattag tcagccatgg ggcggagaat gggcggaact     7260

gggcggagtt aggggcggga tgggcggagt taggggcggg actatggttg ctgactaatt     7320

gagatgagct tgcatgccga cattgattat tgactagtcc ctaagaaacc attcttatca     7380

tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtc                     7425


<210>  3
<211>  7450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide sequence of a MND promoter anti-kappa light chain 
       CAR construct.

<400>  3
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatcatat gccagcctat ggtgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc ggttttggca      600

gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat      660

tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa aatgtcgtaa      720

caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag      780

cagagctcgt ttagtgaacc gggtctctct ggttagacca gatctgagcc tgggagctct      840

ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgctcaaag      900

tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt      960

cagtgtggaa aatctctagc agtggcgccc gaacagggac ttgaaagcga aagtaaagcc     1020

agaggagatc tctcgacgca ggactcggct tgctgaagcg cgcacggcaa gaggcgaggg     1080

gcggcgactg gtgagtacgc caaaaatttt gactagcgga ggctagaagg agagagtagg     1140

gtgcgagagc gtcggtatta agcgggggag aattagataa atgggaaaaa attcggttaa     1200

ggccaggggg aaagaaacaa tataaactaa aacatatagt tagggcaagc agggagctag     1260

aacgattcgc agttaatcct ggccttttag agacatcaga aggctgtaga caaatactgg     1320

gacagctaca accatccctt cagacaggat cagaagaact tagatcatta tataatacaa     1380

tagcagtcct ctattgtgtg catcaaagga tagatgtaaa agacaccaag gaagccttag     1440

ataagataga ggaagagcaa aacaaaagta agaaaaaggc acagcaagca gcagctgaca     1500

caggaaacaa cagccaggtc agccaaaatt accctatagt gcagaacctc caggggcaaa     1560

tggtacatca ggccatatca cctagaactt taaattaaga cagcagtaca aatggcagta     1620

ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg ggaaagaata     1680

gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat tacaaaaatt     1740

caaaattttc gggtttatta cagggacagc agagatccag tttggaaagg accagcaaag     1800

ctcctctgga aaggtgaagg ggcagtagta atacaagata atagtgacat aaaagtagtg     1860

ccaagaagaa aagcaaagat catcagggat tatggaaaac agatggcagg tgatgattgt     1920

gtggcaagta gacaggatga ggattaacac atggaaaaga ttagtaaaac accatagctc     1980

tagagcgatc ccgatcttca gacctggagg aggagatatg agggacaatt ggagaagtga     2040

attatataaa tataaagtag taaaaattga accattagga gtagcaccca ccaaggcaaa     2100

gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt tccttgggtt     2160

cttgggagca gcaggaagca ctatgggcgc agcgtcaatg acgctgacgg tacaggccag     2220

acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta ttgaggcgca     2280

acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa gaatcctggc     2340

tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct ctggaaaact     2400

catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc tggaacagat     2460

ttggaatcac acgacctgga tggagtggga cagagaaatt aacaattaca caagcttggt     2520

aggtttaaga atagtttttg ctgtactttc tatagtgaat agagttaggc agggatattc     2580

accattatcg tttcagaccc acctcccaac cccgagggga cccgacaggc ccgaaggaat     2640

agaagaagaa ggtggagaga gagacagaga cagatccatt cgattagtga acggatccat     2700

cgattagtcc aatttgttaa agacaggata tcagtggtcc aggctctagt tttgactcaa     2760

caatatcacc agctgaagcc tatagagtac gagccataga tagaataaaa gattttattt     2820

agtctccaga aaaagggggg aatgaaagac cccacctgta ggtttggcaa gctaggatca     2880

aggttaggaa cagagagaca gcagaatatg ggccaaacag gatatctgtg gtaagcagtt     2940

cctgccccgg ctcagggcca agaacagttg gaacagcaga atatgggcca aacaggatat     3000

ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggtccc cagatgcggt     3060

cccgccctca gcagtttcta gagaaccatc agatgtttcc agggtgcccc aaggacctga     3120

aatgaccctg tgccttattt gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg     3180

cttctgctcc ccgagctcaa taaaagagcc cacaacccct cactcggcgc gacgcgttag     3240

ccaccatgga gtttgggctg agctggcttt ttcttgtggc tattttaaaa ggtgtccagt     3300

gcgatgttat gctgacccaa actccactct ccctgcctgt cagtcttgga gatcaagcct     3360

ccatctcttg cagatctagt cagagcattt tacatagtac tggagacacc tatttagaat     3420

ggtacctgca gaaaccaggc cagtctccaa agctcctgat caacaaagtt tccaatcgat     3480

tgtctggggt cccagacagg ttcagtggca gtggatcagg gacagatttc acactcaaga     3540

tcagcagagt ggaggctgag gatctgggag tttattactg ctttcaaggt tcacatgttc     3600

cgtggacgtt cggtggaggc accaagctgg aaatcaaacg ggctgatgct gcaccaactg     3660

tatccatctt cccaggtggc ggtggctcgg gcggtggtgg gtcgggtggc ggcggatcac     3720

aggtgaagct tcagcagtca ggacctagcc tggtgaagcc tggggcttca gtgaagatgt     3780

cctgcaaggc ttctggatac accttcactg acttctacat gaagtgggtg aagcagagcc     3840

atggaaagag ccttgagtgg attggagata ttaatcctaa cattggtgat actttctaca     3900

accagaaatt caagggcaag gccacattga ctgtcgacaa atcctccagc acagcctaca     3960

tgcagctcaa cagcctgaca tctgaggact ctgcagtcta tttctgttca gttgggtact     4020

tcgatgtctg gggcgcaggg accacggtca ccgtctcctc aaccacgacg ccagcgccgc     4080

gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt     4140

gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct     4200

acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gtgatcaccc     4260

tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca tttatgagac     4320

cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa gaagaagaag     4380

gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg taccagcagg     4440

gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg     4500

acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag aaccctcagg     4560

aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga     4620

tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag     4680

ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc taatgacagg     4740

tacctttaag accaatgact tacaaggcag ctgtagatct tagccacttt ttaaaagaaa     4800

aggggggact ggaagggcta attcactccc aaagaagaca agatctgctt tttgcctgta     4860

ctgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa ctagggaacc     4920

cactgcttaa gcctcaataa agcttgcctt gagtgcttca atgtgtgtgt tggttttttg     4980

tgtgtcgaaa ttctagcgat tctagcttgg cgtaccagcc tatggcgctc acaattccac     5040

acaacatacg agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac     5100

tcacattaat tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc     5160

tgcattaatg aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg     5220

cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc     5280

actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt     5340

gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc     5400

ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa     5460

acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc     5520

ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg     5580

cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc     5640

tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc     5700

gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca     5760

ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact     5820

acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg     5880

gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt     5940

ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct     6000

tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga     6060

gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa     6120

tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac     6180

ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga     6240

taactacgat acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc     6300

cacgctcacc ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca     6360

gaagtggtcc tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta     6420

gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt tgccattgct acaggcatcg     6480

tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc     6540

gagttacatg atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg     6600

ttgtcagaag taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt     6660

ctcttactgt catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt     6720

cattctgaga atagtgtatg cggcgaccga gttgctcttg cccggcgtca atacgggata     6780

ataccgcgcc acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc     6840

gaaaactctc aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac     6900

ccaactgatc ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa     6960

ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct     7020

tcctttttca atattattga agcatttatc agggttattg tctcatgagc ggatacatat     7080

ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc     7140

cacctgggac tagctttttg caaaagccta ggcctccaaa aaagcctcct cactacttct     7200

ggaatagctc agaggccgag gcggcctcgg cctctgcata aataaaaaaa attagtcagc     7260

catggggcgg agaatgggcg gaactgggcg gagttagggg cgggatgggc ggagttaggg     7320

gcgggactat ggttgctgac taattgagat gagcttgcat gccgacattg attattgact     7380

agtccctaag aaaccattct tatcatgaca ttaacctata aaaataggcg tatcacgagg     7440

ccctttcgtc                                                            7450


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  4

Asp Gly Gly Gly Ser 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  5

Thr Gly Glu Lys Pro 
1               5   


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  6

Gly Gly Arg Arg 
1               


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  7

Gly Gly Gly Gly Ser 
1               5   


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  8

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  9
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  9

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  10

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  11

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  12

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide linker

<400>  13

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide cleavage sequences


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa  is Gly or Ser

<400>  14

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide cleavage sequences

<400>  15

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide cleavage sequences

<400>  16

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  17
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic self-cleaving polypeptide

<400>  17

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic self-cleaving polypeptide

<400>  18

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic self-cleaving polypeptide

<400>  19

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic self-cleaving polypeptide

<400>  20

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic self-cleaving polypeptide

<400>  21

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  22
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic self-cleaving polypeptide

<400>  22

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  23
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic self-cleaving polypeptide

<400>  23

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr 
        35                  40  


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic self-cleaving polypeptide

<400>  24

Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  25
<211>  40
<212>  PRT
<213>  Artificial Sequenceq

<220>
<223>  Synthetic self-cleaving polypeptide

<400>  25

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  26
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic self-cleaving polypeptide

<400>  26

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  27
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus Kozak sequence

<400>  27
gccrccatgg                                                              10


