                         SEQUENCE LISTING

<110>  Institut d'Investigaci Biomdica de Bellvitge (IDIBELL)
       Institut Catal d'Oncologia
 
<120>  ADENOVIRUS COMPRISING AN ALBUMIN-BINDING MOIETY

<130>  P10559PC00

<150>  EP 14382162
<151>  2014-04-30

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  PRT
<213>  Streptococcus

<400>  1

Cys Glu Trp Asp Glu Ala Ala Thr Ala Leu Glu Ile Asn Leu Glu Glu 
1               5                   10                  15      


Glu Asp Asp Asp Asn Glu Asp Glu Val Asp Glu Gln Ala Glu Gln Gln 
            20                  25                  30          


Lys Thr His Val 
        35      


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  2

Gly Ser Gly Ser 
1               


<210>  3
<211>  3021
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Complete modified adenoviral hexon having ABD inserted in HVR1

<400>  3
atggctaccc cttcgatgat gccgcagtgg tcttacatgc acatctcggg ccaggacgcc       60

tcggagtacc tgagccccgg gctggtgcag tttgcccgcg ccaccgagac gtacttcagc      120

ctgaataaca agtttagaaa ccccacggtg gcgcctacgc acgacgtgac cacagaccgg      180

tcccagcgtt tgacgctgcg gttcatccct gtggaccgtg aggatactgc gtactcgtac      240

aaggcgcggt tcaccctagc tgtgggtgat aaccgtgtgc tggacatggc ttccacgtac      300

tttgacatcc gcggcgtgct ggacaggggc cctactttta agccctactc tggcactgcc      360

tacaacgccc tggctcccaa gggtgcccca aatccttgcg aatgggatga agctgctact      420

gctcttgaaa taaacctaga agaagaggac ggcagcggat ccctggccga ggctaaggtg      480

cttgcgaacc gggaactaga caaatacggt gtttctgatt attacaagaa tttgattaac      540

aatgccaaaa ccgtcgaggg cgtaaaggct ctgatcgacg aaatacttgc ggccctaccc      600

gggtctggta gcgatgacaa cgaagacgaa gtagacgagc aagctgagca gcaaaaaact      660

cacgtatttg ggcaggcgcc ttattctggt ataaatatta caaaggaggg tattcaaata      720

ggtgtcgaag gtcaaacacc taaatatgcc gataaaacat ttcaacctga acctcaaata      780

ggagaatctc agtggtacga aacagaaatt aatcatgcag ctgggagagt cctaaaaaag      840

actaccccaa tgaaaccatg ttacggttca tatgcaaaac ccacaaatga aaatggaggg      900

caaggcattc ttgtaaagca acaaaatgga aagctagaaa gtcaagtgga aatgcaattt      960

ttctcaacta ctgaggcagc cgcaggcaat ggtgataact tgactcctaa agtggtattg     1020

tacagtgaag atgtagatat agaaacccca gacactcata tttcttacat gcccactatt     1080

aaggaaggta actcacgaga actaatgggc caacaatcta tgcccaacag gcctaattac     1140

attgctttta gggacaattt tattggtcta atgtattaca acagcacggg taatatgggt     1200

gttctggcgg gccaagcatc gcagttgaat gctgttgtag atttgcaaga cagaaacaca     1260

gagctttcat accagctttt gcttgattcc attggtgata gaaccaggta cttttctatg     1320

tggaatcagg ctgttgacag ctatgatcca gatgttagaa ttattgaaaa tcatggaact     1380

gaagatgaac ttccaaatta ctgctttcca ctgggaggtg tgattaatac agagactctt     1440

accaaggtaa aacctaaaac aggtcaggaa aatggatggg aaaaagatgc tacagaattt     1500

tcagataaaa atgaaataag agttggaaat aattttgcca tggaaatcaa tctaaatgcc     1560

aacctgtgga gaaatttcct gtactccaac atagcgctgt atttgcccga caagctaaag     1620

tacagtcctt ccaacgtaaa aatttctgat aacccaaaca cctacgacta catgaacaag     1680

cgagtggtgg ctcccgggct agtggactgc tacattaacc ttggagcacg ctggtccctt     1740

gactatatgg acaacgtcaa cccatttaac caccaccgca atgctggcct gcgctaccgc     1800

tcaatgttgc tgggcaatgg tcgctatgtg cccttccaca tccaggtgcc tcagaagttc     1860

tttgccatta aaaacctcct tctcctgccg ggctcataca cctacgagtg gaacttcagg     1920

aaggatgtta acatggttct gcagagctcc ctaggaaatg acctaagggt tgacggagcc     1980

agcattaagt ttgatagcat ttgcctttac gccaccttct tccccatggc ccacaacacc     2040

gcctccacgc ttgaggccat gcttagaaac gacaccaacg accagtcctt taacgactat     2100

ctctccgccg ccaacatgct ctaccctata cccgccaacg ctaccaacgt gcccatatcc     2160

atcccctccc gcaactgggc ggctttccgc ggctgggcct tcacgcgcct taagactaag     2220

gaaaccccat cactgggctc gggctacgac ccttattaca cctactctgg ctctataccc     2280

tacctagatg gaacctttta cctcaaccac acctttaaga aggtggccat tacctttgac     2340

tcttctgtca gctggcctgg caatgaccgc ctgcttaccc ccaacgagtt tgaaattaag     2400

cgctcagttg acggggaggg ttacaacgtt gcccagtgta acatgaccaa agactggttc     2460

ctggtacaaa tgctagctaa ctataacatt ggctaccagg gcttctatat cccagagagc     2520

tacaaggacc gcatgtactc cttctttaga aacttccagc ccatgagccg tcaggtggtg     2580

gatgatacta aatacaagga ctaccaacag gtgggcatcc tacaccaaca caacaactct     2640

ggatttgttg gctaccttgc ccccaccatg cgcgaaggac aggcctaccc tgctaacttc     2700

ccctatccgc ttataggcaa gaccgcagtt gacagcatta cccagaaaaa gtttctttgc     2760

gatcgcaccc tttggcgcat cccattctcc agtaacttta tgtccatggg cgcactcaca     2820

gacctgggcc aaaaccttct ctacgccaac tccgcccacg cgctagacat gacttttgag     2880

gtggatccca tggacgagcc cacccttctt tatgttttgt ttgaagtctt tgacgtggtc     2940

cgtgtgcacc agccgcaccg cggcgtcatc gaaaccgtgt acctgcgcac gcccttctcg     3000

gccggcaacg ccacaacata a                                               3021


<210>  4
<211>  3021
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Complete modified adenoviral hexon having ABD inserted in HVR5

<400>  4
atggctaccc cttcgatgat gccgcagtgg tcttacatgc acatctcggg ccaggacgcc       60

tcggagtacc tgagccccgg gctggtgcag tttgcccgcg ccaccgagac gtacttcagc      120

ctgaataaca agtttagaaa ccccacggtg gcgcctacgc acgacgtgac cacagaccgg      180

tcccagcgtt tgacgctgcg gttcatccct gtggaccgtg aggatactgc gtactcgtac      240

aaggcgcggt tcaccctagc tgtgggtgat aaccgtgtgc tggacatggc ttccacgtac      300

tttgacatcc gcggcgtgct ggacaggggc cctactttta agccctactc tggcactgcc      360

tacaacgccc tggctcccaa gggtgcccca aatccttgcg aatgggatga agctgctact      420

gctcttgaaa taaacctaga agaagaggac gatgacaacg aagacgaagt agacgagcaa      480

gctgagcagc aaaaaactca cgtatttggg caggcgcctt attctggtat aaatattaca      540

aaggagggta ttcaaatagg tgtcgaaggt caaacaccta aatatgccga taaaacattt      600

caacctgaac ctcaaatagg agaatctcag tggtacgaaa cagaaattaa tcatgcagct      660

gggagagtcc taaaaaagac taccccaatg aaaccatgtt acggttcata tgcaaaaccc      720

acaaatgaaa atggagggca aggcattctt gtaaagcaac aaaatggaaa gctagaaagt      780

caagtggaaa tgcaattttt ctcaactact gaggcagccg caggcagcgg atccctggcc      840

gaggctaagg tgcttgcgaa ccgggaacta gacaaatacg gtgtttctga ttattacaag      900

aatttgatta acaatgccaa aaccgtcgag ggcgtaaagg ctctgatcga cgaaatactt      960

gcggccctac ccgggtctgg tagcggcaat ggtgataact tgactcctaa agtggtattg     1020

tacagtgaag atgtagatat agaaacccca gacactcata tttcttacat gcccactatt     1080

aaggaaggta actcacgaga actaatgggc caacaatcta tgcccaacag gcctaattac     1140

attgctttta gggacaattt tattggtcta atgtattaca acagcacggg taatatgggt     1200

gttctggcgg gccaagcatc gcagttgaat gctgttgtag atttgcaaga cagaaacaca     1260

gagctttcat accagctttt gcttgattcc attggtgata gaaccaggta cttttctatg     1320

tggaatcagg ctgttgacag ctatgatcca gatgttagaa ttattgaaaa tcatggaact     1380

gaagatgaac ttccaaatta ctgctttcca ctgggaggtg tgattaatac agagactctt     1440

accaaggtaa aacctaaaac aggtcaggaa aatggatggg aaaaagatgc tacagaattt     1500

tcagataaaa atgaaataag agttggaaat aattttgcca tggaaatcaa tctaaatgcc     1560

aacctgtgga gaaatttcct gtactccaac atagcgctgt atttgcccga caagctaaag     1620

tacagtcctt ccaacgtaaa aatttctgat aacccaaaca cctacgacta catgaacaag     1680

cgagtggtgg ctcccgggct agtggactgc tacattaacc ttggagcacg ctggtccctt     1740

gactatatgg acaacgtcaa cccatttaac caccaccgca atgctggcct gcgctaccgc     1800

tcaatgttgc tgggcaatgg tcgctatgtg cccttccaca tccaggtgcc tcagaagttc     1860

tttgccatta aaaacctcct tctcctgccg ggctcataca cctacgagtg gaacttcagg     1920

aaggatgtta acatggttct gcagagctcc ctaggaaatg acctaagggt tgacggagcc     1980

agcattaagt ttgatagcat ttgcctttac gccaccttct tccccatggc ccacaacacc     2040

gcctccacgc ttgaggccat gcttagaaac gacaccaacg accagtcctt taacgactat     2100

ctctccgccg ccaacatgct ctaccctata cccgccaacg ctaccaacgt gcccatatcc     2160

atcccctccc gcaactgggc ggctttccgc ggctgggcct tcacgcgcct taagactaag     2220

gaaaccccat cactgggctc gggctacgac ccttattaca cctactctgg ctctataccc     2280

tacctagatg gaacctttta cctcaaccac acctttaaga aggtggccat tacctttgac     2340

tcttctgtca gctggcctgg caatgaccgc ctgcttaccc ccaacgagtt tgaaattaag     2400

cgctcagttg acggggaggg ttacaacgtt gcccagtgta acatgaccaa agactggttc     2460

ctggtacaaa tgctagctaa ctataacatt ggctaccagg gcttctatat cccagagagc     2520

tacaaggacc gcatgtactc cttctttaga aacttccagc ccatgagccg tcaggtggtg     2580

gatgatacta aatacaagga ctaccaacag gtgggcatcc tacaccaaca caacaactct     2640

ggatttgttg gctaccttgc ccccaccatg cgcgaaggac aggcctaccc tgctaacttc     2700

ccctatccgc ttataggcaa gaccgcagtt gacagcatta cccagaaaaa gtttctttgc     2760

gatcgcaccc tttggcgcat cccattctcc agtaacttta tgtccatggg cgcactcaca     2820

gacctgggcc aaaaccttct ctacgccaac tccgcccacg cgctagacat gacttttgag     2880

gtggatccca tggacgagcc cacccttctt tatgttttgt ttgaagtctt tgacgtggtc     2940

cgtgtgcacc agccgcaccg cggcgtcatc gaaaccgtgt acctgcgcac gcccttctcg     3000

gccggcaacg ccacaacata a                                               3021


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  5

Ser Gly Gly Thr Ser Gly Ser Thr Ser Gly Thr Gly Ser Thr 
1               5                   10                  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  6

Ala Gly Ser Ser Thr Gly Ser Ser Thr Gly Pro Gly Ser Thr Thr 
1               5                   10                  15  


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  7

Gly Gly Ser Gly Gly Ala Pro 
1               5           


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  8

Gly Gly Gly Val Glu Gly Gly Gly 
1               5               


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Core sequence of an albumin-binding peptide

<400>  9

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210>  10
<211>  4
<212>  PRT
<213>  Human adenovirus type 5

<400>  10

Lys Lys Thr Lys 
1               


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified capsid domain

<400>  11

Arg Gly Asp Lys 
1               


<210>  12
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide HVR1rpsLF

<400>  12
gccctggctc ccaagggtgc cccaaatcct tgcgaatggg gcctggtgat gatggc           56


<210>  13
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide HVR1rpsLR

<400>  13
gtaatattta taccagaata aggcgcctgc ccaaatacgt gagttcagaa gaactcgtca       60

agaag                                                                   65


<210>  14
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide ABDH1F

<400>  14
cccaagggtg ccccaaatcc ttgcgaatgg gatgaagctg ctactgctct tgaaataaac       60

ctagaagaag aggacggcag cggatccctg                                        90


<210>  15
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide ABDR1

<400>  15
cccggttcgc aagcacctta gcctcggcca gggatccgct gccccattc                   49


<210>  16
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide ABDF2

<400>  16
gcttgcgaac cgggaactag acaaatacgg tgtttctgat tattacaag                   49


<210>  17
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide ABDR2

<400>  17
cgacggtttt ggcattgtta atcaaattct tgtaataatc agaaacaccg                  50


<210>  18
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide ABDF3

<400>  18
atgccaaaac cgtcgagggc gtaaaggctc tgatcgacga aatacttgcg                  50


<210>  19
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide ABDR3

<400>  19
atacgtgagt gctaccagac ccgggtaggg ccgcaagtat ttcgtcgatc                  50


<210>  20
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide ABDH1R

<400>  20
cagaataagg cgcctgccca aatacgtgag ttttttgctg ctcagcttgc tcgtctactt       60

cgtcttcgtt gtcatcgcta ccagacccgg g                                      91


<210>  21
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide H5rpsLF

<400>  21
gaaagctaga aagtcaagtg gaaatgcaat ttttctcaac tggcctggtg atgatggc         58


<210>  22
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide H5rpsLR

<400>  22
gtttctatat ctacatcttc actgtacaat accactttag gtcagaagaa ctcgtcaaga       60

ag                                                                      62


<210>  23
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide ABDH5F

<400>  23
ctggccgagg ctaaggtgct tgcgaaccgg gaactagaca aatacggtgt ttctgattat       60

tacaagaatt tgattaacaa tgccaaaacc gtcgagggcg taaaggctct gatcgacgaa      120

atacttgcgg ccctaccc                                                    138


<210>  24
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide ABDH5R

<400>  24
ctggccgagg ctaaggtgct tgcgaaccgg gaactagaca aatacggtgt ttctgattat       60

tacaagaatt tgattaacaa tgccaaaacc gtcgagggcg taaaggctct gatcgacgaa      120

atacttgcgg ccctaccc                                                    138


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide Ad19121F

<400>  25
ctggacatgg cttccacgta                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide Ad19300R

<400>  26
gctcgtctac ttcgtcttcg                                                   20


