                         SEQUENCE LISTING

<110>  Indian Institute of Science
       Indian Institute of Science
 
<120>  POLYPEPTIDES FOR GENERATING ANTI-INFLUENZA ANTIBODIES AND USES 
       THEREOF

<130>  PD012942IN-SC

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA1 fragment first subunit of polypeptide

<400>  1

Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser 
1               5                   10                  15      


Val Asn Leu Leu Glu Asp Ser His 
            20                  


<210>  2
<211>  34
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA1 fragment second subunit of polypeptide

<400>  2

Asn Ser Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly Glu 
1               5                   10                  15      


Cys Pro Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu 
            20                  25                  30          


Arg Asn 
        


<210>  3
<211>  73
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA2 fragment third subunit of polypeptide

<400>  3

Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr Val Ile 
1               5                   10                  15      


Glu Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
            20                  25                  30          


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
        35                  40                  45              


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
    50                  55                  60                  


Glu Arg Thr Leu Asp Phe His Asp Ser 
65                  70              


<210>  4
<211>  72
<212>  DNA
<213>  artificial sequence

<220>
<223>  HA1 fragment first subunit of polypeptide

<400>  4
gacactgttg acacagtact cgagaagaat gtgacagtga cacactctgt taacctgctc       60

gaagacagcc ac                                                           72


<210>  5
<211>  102
<212>  DNA
<213>  artificial sequence

<220>
<223>  HA1 fragment second subunit of polypeptide

<400>  5
aacagcagtc tcccttacca gaatatacac ccagtcacaa taggagagtg cccaaaatac       60

gtcaggagtg ccaaattgag gatggttaca ggactaagga ac                         102


<210>  6
<211>  219
<212>  DNA
<213>  artificial sequence

<220>
<223>  HA2 fragment third subunit of polypeptide

<400>  6
acacaaaatg ccattaacgg gattacaaac aaggtgaaca ctgttatcga gaaaatgaac       60

attcaattca cagctgtggg taaagaattc aacaaattag aaaaaaggat ggaaaattta      120

aataaaaaag ttgatgatgg atttctggac atttggacat ataatgcaga attgttagtt      180

ctactggaaa atgaaaggac tctggatttc catgactca                             219


<210>  7
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA1 fragment of H1N1 A/New Caledonia/20/99HA1  first subunit of 
       polypeptide

<400>  7

Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser 
1               5                   10                  15      


Val Asn Leu Leu Glu Asp Ser His 
            20                  


<210>  8
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA1 fragment of H1NI A/California/04/2009 first subunit of 
       polypeptide

<400>  8

Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser 
1               5                   10                  15      


Val Asn Leu Leu Glu Asp Lys His 
            20                  


<210>  9
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA1 fragment of H5N1 A/Viet Nam/1203/2004 first subunit of 
       polypeptide

<400>  9

Glu Gln Val Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala 
1               5                   10                  15      


Gln Asp Ile Leu Glu Lys Thr His 
            20                  


<210>  10
<211>  34
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA1 fragment of H1N1 A/Puerto Rico/8/34  second subunit of 
       polypeptide

<400>  10

Asn Ser Ser Leu Pro Tyr Gln Asn Thr His Pro Thr Thr Asn Gly Glu 
1               5                   10                  15      


Ser Pro Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu 
            20                  25                  30          


Arg Asn 
        


<210>  11
<211>  34
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA1 fragment of H1NI A/New Caledonia/20/99HA1 second subunit of 
       polypeptide

<400>  11

Asn Ser Ser Leu Pro Phe Gln Asn Thr His Pro Thr Thr Asn Gly Glu 
1               5                   10                  15      


Ser Pro Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu 
            20                  25                  30          


Arg Asn 
        


<210>  12
<211>  34
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA1 fragment of H1NI A/California/04/2009  second subunit of 
       polypeptide

<400>  12

Asn Thr Ser Leu Pro Phe Gln Asn Thr His Pro Thr Thr Asn Gly Lys 
1               5                   10                  15      


Ser Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu 
            20                  25                  30          


Arg Asn 
        


<210>  13
<211>  34
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA1 fragment of H5N1 A/Viet Nam/1203/2004 second subunit of 
       polypeptide

<400>  13

Asn Ser Ser Met Pro Phe His Asn Thr His Pro Asn Thr Thr Gly Glu 
1               5                   10                  15      


Ser Pro Lys Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu 
            20                  25                  30          


Arg Asn 
        


<210>  14
<211>  73
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA2 fragment of H1N1 A/Puerto Rico/8/34  third subunit of 
       polypeptide

<400>  14

Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr Val Ile 
1               5                   10                  15      


Glu Lys Met Asn Ile Gln Asp Thr Ala Thr Gly Lys Glu Phe Asn Lys 
            20                  25                  30          


Asp Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
        35                  40                  45              


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
    50                  55                  60                  


Glu Arg Thr Leu Asp Ala His Asp Ser 
65                  70              


<210>  15
<211>  73
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA2 subunit of H1NI A/New Caledonia/20/99 third subunit of 
       polypeptide

<400>  15

Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
1               5                   10                  15      


Glu Lys Met Asn Thr Gln Asp Thr Ala Val Gly Lys Glu Phe Asn Lys 
            20                  25                  30          


Asp Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
        35                  40                  45              


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
    50                  55                  60                  


Glu Arg Thr Leu Asp Ala His Asp Ser 
65                  70              


<210>  16
<211>  73
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA2 fragment of H1NI A/California/04/2009  third subunit of 
       polypeptide

<400>  16

Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
1               5                   10                  15      


Glu Lys Met Asn Thr Gln Asp Thr Ala Val Gly Lys Glu Phe Asn His 
            20                  25                  30          


Asp Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
        35                  40                  45              


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
    50                  55                  60                  


Glu Arg Thr Leu Asp Ala His Asp Ser 
65                  70              


<210>  17
<211>  73
<212>  PRT
<213>  artificial sequence

<220>
<223>  HA2 fragment of H5N1 A/Viet Nam/1203/2004 third subunit of 
       polypeptide

<400>  17

Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile 
1               5                   10                  15      


Asp Lys Met Asn Thr Gln Phe Glu Ala Asp Gly Arg Glu Phe Asn Asn 
            20                  25                  30          


Asp Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe 
        35                  40                  45              


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn 
    50                  55                  60                  


Glu Arg Thr Leu Asp Ala His Asp Ser 
65                  70              


<210>  18
<211>  72
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 7

<400>  18
gatacggttg acacggtcct ggaaaagaat gtgacggtta cgcactcggt taatctgctg       60

gaagactcgc ac                                                           72


<210>  19
<211>  72
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequnce of SEQ ID NO: 8

<400>  19
gacacggtgg atacggtcct ggaaaagaat gttacggtca cgcactcagt caatctgctg       60

gaagacaagc ac                                                           72


<210>  20
<211>  72
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 9

<400>  20
gaacaagtgg acacgattat ggaaaagaac gtcacggtta cgcacgccca agacatcctg       60

gaaaaaacgc ac                                                           72


<210>  21
<211>  102
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 10

<400>  21
aacagcagcc tgccgtatca gaacacccat ccgaccacca acggcgaaag cccgaaatat       60

gtgcgtagcg cgaaactgcg tatggtgacc ggcctgcgta ac                         102


<210>  22
<211>  102
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 11

<400>  22
aactcctcac tgccgtttca gaacacccat ccgaccacga atggtgaaag tccgaaatat       60

gtccgttccg caaagctgcg tatggttacc ggtctgcgta at                         102


<210>  23
<211>  102
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 12

<400>  23
aatacgtcac tgccgtttca gaacacccat ccgaccacga atggtaaaag tccgaagtat       60

gttaaatcca ccaagctgcg tctggcaacc ggtctgcgta at                         102


<210>  24
<211>  102
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 13

<400>  24
aacagctcaa tgccgtttca taacacccac ccgaatacca cgggtgaaag tccgaaatat       60

gtcaagtcca atcgtctggt gctggcaacc ggtctgcgta at                         102


<210>  25
<211>  219
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 14

<400>  25
acccagaacg cgattaacgg cattaccaac aaagtgaaca ccgtgattga aaaaatgaac       60

attcaggata ccgcgaccgg caaagaattt aacaaagatg aaaaacgtat ggaaaacctg      120

aacaaaaaag tggatgatgg ctttctggat atttggacct ataacgcgga actgctggtg      180

ctgctggaaa acgaacgtac cctggatgcg catgatagc                             219


<210>  26
<211>  219
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 15

<400>  26
acccagaacg caattaatgg tatcacgaac aaggtgaact cggttatcga aaagatgaac       60

acccaagata cggccgtggg caaagaattt aataaggacg aacgtcgcat ggaaaacctg      120

aataaaaagg ttgatgacgg tttcctggat atttggacct ataacgcaga actgctggtc      180

ctgctggaaa atgaacgtac cctggatgct cacgactct                             219


<210>  27
<211>  219
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 16

<400>  27
acccagaatg caattgatga aatcacgaac aaagtgaatt cggttattga aaagatgaac       60

acccaagata cggccgtcgg caaggaattc aaccatgacg aaaagcgtat cgaaaacctg      120

aacaagaagg tcgatgacgg cttcctggat atctggacct ataacgcaga actgctggtg      180

ctgctggaaa atgaacgtac cctggatgct cacgactct                             219


<210>  28
<211>  219
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 17

<400>  28
acccagaaag caattgatgg tgtgacgaac aaggttaact cgatcatcga taagatgaac       60

acccaatttg aagccgatgg ccgtgaattc aacaatgacg aacgtcgcat cgaaaacctg      120

aataaaaaga tggaagatgg tttcctggac gtttggacct ataacgcaga actgctggtc      180

ctgatggaaa atgaacgtac cctggatgct catgactct                             219


<210>  29
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 30

<400>  29
ggcagcgcgg gcagcgcg                                                     18


<210>  30
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker sequence

<400>  30

Gly Ser Ala Gly Ser Ala 
1               5       


<210>  31
<211>  28
<212>  PRT
<213>  artificial sequence

<220>
<223>  isoleucine zipper trimerization motif

<400>  31

Ile Lys Lys Glu Ile Glu Ala Ile Lys Lys Glu Gln Glu Ala Ile Lys 
1               5                   10                  15      


Lys Lys Ile Glu Ala Ile Glu Lys Glu Ile Glu Ala 
            20                  25              


<210>  32
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  Foldon sequence trimerization motif

<400>  32

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  33
<211>  84
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 31

<400>  33
atcaaaaaag aaatcgaagc gatcaaaaaa gaacaggaag ccattaaaaa gaaaattgaa       60

gcaatcgaaa aagaaatcga agcg                                              84


<210>  34
<211>  81
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 32

<400>  34
ggctatattc cggaagcgcc gcgtgatggt caggcctacg tgcgtaaaga tggcgaatgg       60

gttctgctga gcacctttct g                                                 81


<210>  35
<211>  140
<212>  PRT
<213>  artificial sequence

<220>
<223>  sequence of H1HA10 (H1N1 A/Puerto Rico/8/34) polypeptide

<400>  35

Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser 
1               5                   10                  15      


Val Asn Leu Leu Glu Asp Ser His Gly Ser Ala Asn Ser Ser Leu Pro 
            20                  25                  30          


Tyr Gln Asn Thr His Pro Thr Thr Asn Gly Glu Ser Pro Lys Tyr Val 
        35                  40                  45              


Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn Gly Ser Ala 
    50                  55                  60                  


Gly Ser Ala Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn 
65                  70                  75                  80  


Thr Val Ile Glu Lys Met Asn Ile Gln Asp Thr Ala Thr Gly Lys Glu 
                85                  90                  95      


Phe Asn Lys Asp Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp 
            100                 105                 110         


Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
        115                 120                 125             


Leu Glu Asn Glu Arg Thr Leu Asp Ala His Asp Ser 
    130                 135                 140 


<210>  36
<211>  173
<212>  PRT
<213>  artificial sequence

<220>
<223>  sequence of H1HA10-IZ(H1N1 A/Puerto Rico/8/34)

<400>  36

Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser 
1               5                   10                  15      


Val Asn Leu Leu Glu Asp Ser His Gly Ser Ala Asn Ser Ser Leu Pro 
            20                  25                  30          


Tyr Gln Asn Thr His Pro Thr Thr Asn Gly Glu Ser Pro Lys Tyr Val 
        35                  40                  45              


Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn Gly Ser Ala 
    50                  55                  60                  


Gly Ser Ala Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn 
65                  70                  75                  80  


Thr Val Ile Glu Lys Met Asn Ile Gln Asp Thr Ala Thr Gly Lys Glu 
                85                  90                  95      


Phe Asn Lys Asp Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp 
            100                 105                 110         


Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
        115                 120                 125             


Leu Glu Asn Glu Arg Thr Leu Asp Ala His Asp Ser Gln Gly Thr Gly 
    130                 135                 140                 


Gly Ile Lys Lys Glu Ile Glu Ala Ile Lys Lys Glu Gln Glu Ala Ile 
145                 150                 155                 160 


Lys Lys Lys Ile Glu Ala Ile Glu Lys Glu Ile Glu Ala 
                165                 170             


<210>  37
<211>  172
<212>  PRT
<213>  artificial sequence

<220>
<223>  sequence of H1HA10-Foldon(H1N1 A/Puerto Rico/8/34)

<400>  37

Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser 
1               5                   10                  15      


Val Asn Leu Leu Glu Asp Ser His Gly Ser Ala Asn Ser Ser Leu Pro 
            20                  25                  30          


Tyr Gln Asn Thr His Pro Thr Thr Asn Gly Glu Ser Pro Lys Tyr Val 
        35                  40                  45              


Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn Gly Ser Ala 
    50                  55                  60                  


Gly Ser Ala Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn 
65                  70                  75                  80  


Thr Val Ile Glu Lys Met Asn Ile Gln Asp Thr Ala Thr Gly Lys Glu 
                85                  90                  95      


Phe Asn Lys Asp Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp 
            100                 105                 110         


Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
        115                 120                 125             


Leu Glu Asn Glu Arg Thr Leu Asp Ala His Asp Ser Gln Gly Thr Gly 
    130                 135                 140                 


Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg 
145                 150                 155                 160 


Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
                165                 170         


<210>  38
<211>  172
<212>  PRT
<213>  artificial sequence

<220>
<223>  sequence of NCH1HA1-Foldon (H1NI A/New Caledonia/20/99)

<400>  38

Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser 
1               5                   10                  15      


Val Asn Leu Leu Glu Asp Ser His Gly Ser Ala Asn Ser Ser Leu Pro 
            20                  25                  30          


Phe Gln Asn Thr His Pro Thr Thr Asn Gly Glu Ser Pro Lys Tyr Val 
        35                  40                  45              


Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn Gly Ser Ala 
    50                  55                  60                  


Gly Ser Ala Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn 
65                  70                  75                  80  


Ser Val Ile Glu Lys Met Asn Thr Gln Asp Thr Ala Val Gly Lys Glu 
                85                  90                  95      


Phe Asn Lys Asp Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp 
            100                 105                 110         


Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
        115                 120                 125             


Leu Glu Asn Glu Arg Thr Leu Asp Ala His Asp Ser Gln Gly Thr Gly 
    130                 135                 140                 


Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg 
145                 150                 155                 160 


Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
                165                 170         


<210>  39
<211>  172
<212>  PRT
<213>  artificial sequence

<220>
<223>  sequence of pH1HA1-Foldon (H1N1 A/California/04/2009)

<400>  39

Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser 
1               5                   10                  15      


Val Asn Leu Leu Glu Asp Lys His Gly Ser Ala Asn Thr Ser Leu Pro 
            20                  25                  30          


Phe Gln Asn Thr His Pro Thr Thr Asn Gly Lys Ser Pro Lys Tyr Val 
        35                  40                  45              


Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Gly Ser Ala 
    50                  55                  60                  


Gly Ser Ala Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn 
65                  70                  75                  80  


Ser Val Ile Glu Lys Met Asn Thr Gln Asp Thr Ala Val Gly Lys Glu 
                85                  90                  95      


Phe Asn His Asp Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp 
            100                 105                 110         


Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
        115                 120                 125             


Leu Glu Asn Glu Arg Thr Leu Asp Ala His Asp Ser Gln Gly Thr Gly 
    130                 135                 140                 


Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg 
145                 150                 155                 160 


Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
                165                 170         


<210>  40
<211>  172
<212>  PRT
<213>  artificial sequence

<220>
<223>  sequence of H5HA10-Foldon (H5N1 A/Viet Nam/1203/2004)

<400>  40

Glu Gln Val Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala 
1               5                   10                  15      


Gln Asp Ile Leu Glu Lys Thr His Gly Ser Ala Asn Ser Ser Met Pro 
            20                  25                  30          


Phe His Asn Thr His Pro Asn Thr Thr Gly Glu Ser Pro Lys Tyr Val 
        35                  40                  45              


Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Gly Ser Ala 
    50                  55                  60                  


Gly Ser Ala Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn 
65                  70                  75                  80  


Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Asp Gly Arg Glu 
                85                  90                  95      


Phe Asn Asn Asp Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu 
            100                 105                 110         


Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu 
        115                 120                 125             


Met Glu Asn Glu Arg Thr Leu Asp Ala His Asp Ser Gln Gly Thr Gly 
    130                 135                 140                 


Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg 
145                 150                 155                 160 


Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
                165                 170         


<210>  41
<211>  423
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 35

<400>  41
gataccgtgg ataccgtgct ggaaaagaac gtgaccgtga cccatagcgt gaacctgctg       60

gaagatagcc atggcagcgc gaacagcagc ctgccgtatc agaacaccca tccgaccacc      120

aacggcgaaa gcccgaaata tgtgcgtagc gcgaaactgc gtatggtgac cggcctgcgt      180

aacggcagcg cgggcagcgc gacccagaac gcgattaacg gcattaccaa caaagtgaac      240

accgtgattg aaaaaatgaa cattcaggat accgcgaccg gcaaagaatt taacaaagat      300

gaaaaacgta tggaaaacct gaacaaaaaa gtggatgatg gctttctgga tatttggacc      360

tataacgcgg aactgctggt gctgctggaa aacgaacgta ccctggatgc gcatgatagc      420

taa                                                                    423


<210>  42
<211>  522
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequenece of SEQ ID NO: 36

<400>  42
gataccgtgg ataccgtgct ggaaaagaac gtgaccgtga cccatagcgt gaacctgctg       60

gaagatagcc atggcagcgc gaacagcagc ctgccgtatc agaacaccca tccgaccacc      120

aacggcgaaa gcccgaaata tgtgcgtagc gcgaaactgc gtatggtgac cggcctgcgt      180

aacggcagcg cgggcagcgc gacccagaac gcgattaacg gcattaccaa caaagtgaac      240

accgtgattg aaaaaatgaa cattcaggat accgcgaccg gcaaagaatt taacaaagat      300

gaaaaacgta tggaaaacct gaacaaaaaa gtggatgatg gctttctgga tatttggacc      360

tataacgcgg aactgctggt gctgctggaa aacgaacgta ccctggatgc gcatgatagc      420

caaggtaccg gcggtatcaa aaaagaaatc gaagcgatca aaaaagaaca ggaagccatt      480

aaaaagaaaa ttgaagcaat cgaaaaagaa atcgaagcgt ag                         522


<210>  43
<211>  519
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 37

<400>  43
gataccgtgg ataccgtgct ggaaaagaac gtgaccgtga cccatagcgt gaacctgctg       60

gaagatagcc atggcagcgc gaacagcagc ctgccgtatc agaacaccca tccgaccacc      120

aacggcgaaa gcccgaaata tgtgcgtagc gcgaaactgc gtatggtgac cggcctgcgt      180

aacggcagcg cgggcagcgc gacccagaac gcgattaacg gcattaccaa caaagtgaac      240

accgtgattg aaaaaatgaa cattcaggat accgcgaccg gcaaagaatt taacaaagat      300

gaaaaacgta tggaaaacct gaacaaaaaa gtggatgatg gctttctgga tatttggacc      360

tataacgcgg aactgctggt gctgctggaa aacgaacgta ccctggatgc gcatgatagc      420

caaggtaccg gcggtggcta tattccggaa gcgccgcgtg atggtcaggc ctacgtgcgt      480

aaagatggcg aatgggttct gctgagcacc tttctgtaa                             519


<210>  44
<211>  519
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 38

<400>  44
gatacggttg acacggtcct ggaaaagaat gtgacggtta cgcactcggt taatctgctg       60

gaagactcgc acggctcggc aaactcctca ctgccgtttc agaacaccca tccgaccacg      120

aatggtgaaa gtccgaaata tgtccgttcc gcaaagctgc gtatggttac cggtctgcgt      180

aatggtagcg ccggctctgc aacccagaac gcaattaatg gtatcacgaa caaggtgaac      240

tcggttatcg aaaagatgaa cacccaagat acggccgtgg gcaaagaatt taataaggac      300

gaacgtcgca tggaaaacct gaataaaaag gttgatgacg gtttcctgga tatttggacc      360

tataacgcag aactgctggt cctgctggaa aatgaacgta ccctggatgc tcacgactct      420

caaggcacgg gcggtggcta catcccggaa gcgccgcgtg atggtcaggc gtatgttcgt      480

aaagatggtg aatgggtgct gctgtccacg tttctgtga                             519


<210>  45
<211>  519
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 39

<400>  45
gacacggtgg atacggtcct ggaaaagaat gttacggtca cgcactcagt caatctgctg       60

gaagacaagc acggttcggc aaatacgtca ctgccgtttc agaacaccca tccgaccacg      120

aatggtaaaa gtccgaagta tgttaaatcc accaagctgc gtctggcaac cggtctgcgt      180

aatggtagcg ccggctctgc cacccagaat gcaattgatg aaatcacgaa caaagtgaat      240

tcggttattg aaaagatgaa cacccaagat acggccgtcg gcaaggaatt caaccatgac      300

gaaaagcgta tcgaaaacct gaacaagaag gtcgatgacg gcttcctgga tatctggacc      360

tataacgcag aactgctggt gctgctggaa aatgaacgta ccctggatgc tcacgactct      420

cagggtacgg gcggtggcta catcccggaa gcgccgcgtg atggtcaggc gtatgtgcgt      480

aaagacggcg aatgggtgct gctgtccacg tttctgtga                             519


<210>  46
<211>  519
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 40

<400>  46
gaacaagtgg acacgattat ggaaaagaac gtcacggtta cgcacgccca agacatcctg       60

gaaaaaacgc acggctcagc gaacagctca atgccgtttc ataacaccca cccgaatacc      120

acgggtgaaa gtccgaaata tgtcaagtcc aatcgtctgg tgctggcaac cggtctgcgt      180

aatggtagcg ccggctctgc cacccagaaa gcaattgatg gtgtgacgaa caaggttaac      240

tcgatcatcg ataagatgaa cacccaattt gaagccgatg gccgtgaatt caacaatgac      300

gaacgtcgca tcgaaaacct gaataaaaag atggaagatg gtttcctgga cgtttggacc      360

tataacgcag aactgctggt cctgatggaa aatgaacgta ccctggatgc tcatgactct      420

cagggcacgg gcggtggcta cattccggaa gcgccgcgtg acggtcaggc gtatgtccgc      480

aaggatggtg aatgggtgct gctgtccacg tttctgtga                             519


<210>  47
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker sequence

<400>  47

Gln Gly Thr Gly Gly 
1               5   


<210>  48
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 47

<400>  48
caaggtaccg gcggt                                                        15


<210>  49
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker sequence

<400>  49

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  50
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker sequence

<400>  50

Gly Ser Gly Ser Gly Ser 
1               5       


<210>  51
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker sequence

<400>  51

Gly Ser Ser Gly Ser Ser 
1               5       


<210>  52
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 49

<400>  52
ggcggcggtg gtggcggc                                                     18


<210>  53
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 50

<400>  53
ggctccggtt ctggctct                                                     18


<210>  54
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence of SEQ ID NO: 51

<400>  54
ggctcttccg gttcctct                                                     18


