                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  Novel vertebrate cells and methods for recombinantly expressing a
        polypeptide of interest

<130>  PAT056118-WO-PCT

<150>  US 61/985,589
<151>  2014-04-29

<150>  US 61/994,310
<151>  2014-05-16

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  855
<212>  PRT
<213>  Cricetulus griseus

<400>  1

Met Gly Ser Asn Arg Gly Arg Lys Ala Gly Gly Ser Ser Lys Asp Phe 
1               5                   10                  15      


Gly Ala Arg Leu Lys Tyr Ser Ser Gly Leu Glu Asn Met Asn Gly Phe 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu Pro Val Asn Asn Ala Lys Lys Val Glu 
        35                  40                  45              


Lys Arg Gly Pro Arg Arg Cys Val Val Leu Val Val Leu Leu Val Ser 
    50                  55                  60                  


Phe Leu Phe Leu Ser Leu Val Ala Gly Phe Leu Val Trp His Phe Leu 
65                  70                  75                  80  


Tyr Ser Asn Val Arg Ile Gln Lys Val Phe Asn Gly His Leu Arg Val 
                85                  90                  95      


Thr Asn Glu Asn Phe Leu Asp Ala Tyr Glu Asn Ser Asn Ser Thr Glu 
            100                 105                 110         


Phe Lys Asp Leu Ala Asn Gln Val Lys Glu Ala Leu Lys Leu Leu Tyr 
        115                 120                 125             


Ser Glu Val Pro Val Leu Gly Pro Tyr His Lys Arg Ser Ala Val Thr 
    130                 135                 140                 


Ala Phe Ser Glu Gly Ser Val Ile Ala Tyr Tyr Trp Ser Glu Phe Ser 
145                 150                 155                 160 


Ile Pro Pro His Leu Ala Glu Glu Val Asp Arg Ala Met Ala Val Glu 
                165                 170                 175     


Arg Val Val Thr Leu Pro Pro Arg Ala Arg Ala Leu Lys Ser Phe Val 
            180                 185                 190         


Leu Thr Ser Val Val Ala Phe Pro Thr Asp Pro Arg Leu Leu Gly Arg 
        195                 200                 205             


Thr Gln Asp Asn Ser Cys Asn Phe Ala Leu His Ala His Gly Gly Glu 
    210                 215                 220                 


Val Met Arg Phe Thr Thr Pro Gly Phe Pro Asn Ser Pro Tyr Pro Ala 
225                 230                 235                 240 


His Ala Arg Cys Gln Trp Val Leu Arg Gly Asp Ala Asp Ser Val Leu 
                245                 250                 255     


Ser Leu Thr Phe Arg Ser Phe Asp Val Ala Pro Cys Asp Glu Leu Gly 
            260                 265                 270         


Asn Asp Leu Val Thr Val Tyr Asp Thr Leu Ser Pro Met Glu Pro His 
        275                 280                 285             


Ala Val Val Arg Leu Cys Gly Thr Tyr Pro Pro Ser Tyr Asn Leu Thr 
    290                 295                 300                 


Phe Leu Ser Ser Gln Asn Val Phe Leu Val Thr Leu Ile Thr Asn Thr 
305                 310                 315                 320 


Asp Arg Arg His Pro Gly Phe Glu Ala Thr Phe Phe Gln Leu Pro Lys 
                325                 330                 335     


Met Arg Ser Cys Gly Gly Ser Leu Ser Glu Ala Gln Gly Leu Phe Ser 
            340                 345                 350         


Ser Pro Tyr Tyr Pro Gly His Tyr Pro Pro Asn Ile Asp Cys Thr Trp 
        355                 360                 365             


Asn Ile Lys Val Pro Asn Asn Arg Asn Val Lys Val Arg Phe Lys Leu 
    370                 375                 380                 


Phe Tyr Leu Val Asp Pro Asn Ile Pro Leu Gly Thr Cys Pro Lys Asp 
385                 390                 395                 400 


Tyr Val Glu Ile Asn Gly Glu Arg Tyr Cys Gly Glu Lys Ser Gln Phe 
                405                 410                 415     


Val Val Ser Ser Asn Ser Ser Lys Ile Thr Val Arg Phe His Ser Asp 
            420                 425                 430         


His Ser Tyr Thr Asp Thr Gly Phe Leu Ala Glu Tyr Leu Ser Tyr Asp 
        435                 440                 445             


Ser Asn Asp Pro Cys Pro Gly Met Phe Met Cys Asn Thr Gly Arg Cys 
    450                 455                 460                 


Ile Arg Lys Asp Leu Arg Cys Asp Gly Trp Ala Asp Cys Pro Asp Tyr 
465                 470                 475                 480 


Ser Asp Glu His Phe Cys Arg Cys Asn Thr Thr His Gln Phe Met Cys 
                485                 490                 495     


Lys Asn Lys Leu Cys Lys Pro Leu Phe Trp Val Cys Asp Asn Ile Asn 
            500                 505                 510         


Asp Cys Gly Asp Gly Ser Asp Glu Glu Gly Cys Ser Cys Pro Ala Glu 
        515                 520                 525             


Thr Phe Lys Cys Ser Asn Gly Lys Cys Leu Pro Gln Ser Gln Lys Cys 
    530                 535                 540                 


Asp Gly Lys Asp Asn Cys Gly Asp Gly Ser Asp Glu Ala Ser Cys Asp 
545                 550                 555                 560 


Arg Val Lys Val Val Ser Cys Thr Lys Tyr Thr Tyr Arg Cys His Asn 
                565                 570                 575     


Gly Leu Cys Leu Ser Lys Gly Asn Pro Glu Cys Asp Gly Lys Lys Asp 
            580                 585                 590         


Cys Ser Asp Gly Ser Asp Glu Lys Asn Cys Asp Cys Gly Leu Arg Ser 
        595                 600                 605             


Phe Thr Lys Gln Ala Arg Val Val Gly Gly Thr Asn Ala Asp Glu Gly 
    610                 615                 620                 


Glu Trp Pro Trp Gln Val Ser Leu His Ala Leu Gly Gln Gly His Leu 
625                 630                 635                 640 


Cys Gly Ala Ser Leu Ile Ser Pro Asn Trp Leu Val Ser Ala Ala His 
                645                 650                 655     


Cys Phe Met Asp Asp Arg Asn Phe Lys Tyr Ser Asp His Thr Lys Trp 
            660                 665                 670         


Thr Ala Phe Leu Gly Leu Leu Asp Gln Ser Lys Arg Ser Ser Thr Gly 
        675                 680                 685             


Val Gln Glu His Lys Leu Lys Arg Ile Ile Thr His Pro Leu Phe Asn 
    690                 695                 700                 


Glu Ile Thr Phe Asp Tyr Asp Ile Ala Leu Leu Glu Leu Glu Lys Pro 
705                 710                 715                 720 


Ala Glu Tyr Ser Thr Val Val Arg Pro Ile Cys Leu Pro Asp Thr Thr 
                725                 730                 735     


His Val Phe Pro Ala Gly Lys Ala Ile Trp Val Thr Gly Trp Gly His 
            740                 745                 750         


Thr Gln Glu Gly Gly Thr Gly Ala Leu Ile Leu Gln Lys Gly Glu Ile 
        755                 760                 765             


Arg Val Ile Asn Gln Thr Thr Cys Glu Asp Leu Met Pro Gln Gln Ile 
    770                 775                 780                 


Thr Pro Arg Met Met Cys Val Gly Phe Leu Ser Gly Gly Val Asp Ser 
785                 790                 795                 800 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Ser Ser Val Glu Thr Glu Gly 
                805                 810                 815     


Arg Ile Phe Gln Ala Gly Val Val Ser Trp Gly Glu Gly Cys Ala Gln 
            820                 825                 830         


Arg Asn Lys Pro Gly Val Tyr Thr Arg Leu Pro Ala Val Arg Asp Trp 
        835                 840                 845             


Ile Lys Glu Gln Thr Gly Val 
    850                 855 


<210>  2
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Ser Asp Arg Ala Arg Lys Gly Gly Gly Gly Pro Lys Asp Phe 
1               5                   10                  15      


Gly Ala Gly Leu Lys Tyr Asn Ser Arg His Glu Lys Val Asn Gly Leu 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu Pro Val Asn Asn Val Lys Lys Val Glu 
        35                  40                  45              


Lys His Gly Pro Gly Arg Trp Val Val Leu Ala Ala Val Leu Ile Gly 
    50                  55                  60                  


Leu Leu Leu Val Leu Leu Gly Ile Gly Phe Leu Val Trp His Leu Gln 
65                  70                  75                  80  


Tyr Arg Asp Val Arg Val Gln Lys Val Phe Asn Gly Tyr Met Arg Ile 
                85                  90                  95      


Thr Asn Glu Asn Phe Val Asp Ala Tyr Glu Asn Ser Asn Ser Thr Glu 
            100                 105                 110         


Phe Val Ser Leu Ala Ser Lys Val Lys Asp Ala Leu Lys Leu Leu Tyr 
        115                 120                 125             


Ser Gly Val Pro Phe Leu Gly Pro Tyr His Lys Glu Ser Ala Val Thr 
    130                 135                 140                 


Ala Phe Ser Glu Gly Ser Val Ile Ala Tyr Tyr Trp Ser Glu Phe Ser 
145                 150                 155                 160 


Ile Pro Gln His Leu Val Glu Glu Ala Glu Arg Val Met Ala Glu Glu 
                165                 170                 175     


Arg Val Val Met Leu Pro Pro Arg Ala Arg Ser Leu Lys Ser Phe Val 
            180                 185                 190         


Val Thr Ser Val Val Ala Phe Pro Thr Asp Ser Lys Thr Val Gln Arg 
        195                 200                 205             


Thr Gln Asp Asn Ser Cys Ser Phe Gly Leu His Ala Arg Gly Val Glu 
    210                 215                 220                 


Leu Met Arg Phe Thr Thr Pro Gly Phe Pro Asp Ser Pro Tyr Pro Ala 
225                 230                 235                 240 


His Ala Arg Cys Gln Trp Ala Leu Arg Gly Asp Ala Asp Ser Val Leu 
                245                 250                 255     


Ser Leu Thr Phe Arg Ser Phe Asp Leu Ala Ser Cys Asp Glu Arg Gly 
            260                 265                 270         


Ser Asp Leu Val Thr Val Tyr Asn Thr Leu Ser Pro Met Glu Pro His 
        275                 280                 285             


Ala Leu Val Gln Leu Cys Gly Thr Tyr Pro Pro Ser Tyr Asn Leu Thr 
    290                 295                 300                 


Phe His Ser Ser Gln Asn Val Leu Leu Ile Thr Leu Ile Thr Asn Thr 
305                 310                 315                 320 


Glu Arg Arg His Pro Gly Phe Glu Ala Thr Phe Phe Gln Leu Pro Arg 
                325                 330                 335     


Met Ser Ser Cys Gly Gly Arg Leu Arg Lys Ala Gln Gly Thr Phe Asn 
            340                 345                 350         


Ser Pro Tyr Tyr Pro Gly His Tyr Pro Pro Asn Ile Asp Cys Thr Trp 
        355                 360                 365             


Asn Ile Glu Val Pro Asn Asn Gln His Val Lys Val Arg Phe Lys Phe 
    370                 375                 380                 


Phe Tyr Leu Leu Glu Pro Gly Val Pro Ala Gly Thr Cys Pro Lys Asp 
385                 390                 395                 400 


Tyr Val Glu Ile Asn Gly Glu Lys Tyr Cys Gly Glu Arg Ser Gln Phe 
                405                 410                 415     


Val Val Thr Ser Asn Ser Asn Lys Ile Thr Val Arg Phe His Ser Asp 
            420                 425                 430         


Gln Ser Tyr Thr Asp Thr Gly Phe Leu Ala Glu Tyr Leu Ser Tyr Asp 
        435                 440                 445             


Ser Ser Asp Pro Cys Pro Gly Gln Phe Thr Cys Arg Thr Gly Arg Cys 
    450                 455                 460                 


Ile Arg Lys Glu Leu Arg Cys Asp Gly Trp Ala Asp Cys Thr Asp His 
465                 470                 475                 480 


Ser Asp Glu Leu Asn Cys Ser Cys Asp Ala Gly His Gln Phe Thr Cys 
                485                 490                 495     


Lys Asn Lys Phe Cys Lys Pro Leu Phe Trp Val Cys Asp Ser Val Asn 
            500                 505                 510         


Asp Cys Gly Asp Asn Ser Asp Glu Gln Gly Cys Ser Cys Pro Ala Gln 
        515                 520                 525             


Thr Phe Arg Cys Ser Asn Gly Lys Cys Leu Ser Lys Ser Gln Gln Cys 
    530                 535                 540                 


Asn Gly Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu Ala Ser Cys Pro 
545                 550                 555                 560 


Lys Val Asn Val Val Thr Cys Thr Lys His Thr Tyr Arg Cys Leu Asn 
                565                 570                 575     


Gly Leu Cys Leu Ser Lys Gly Asn Pro Glu Cys Asp Gly Lys Glu Asp 
            580                 585                 590         


Cys Ser Asp Gly Ser Asp Glu Lys Asp Cys Asp Cys Gly Leu Arg Ser 
        595                 600                 605             


Phe Thr Arg Gln Ala Arg Val Val Gly Gly Thr Asp Ala Asp Glu Gly 
    610                 615                 620                 


Glu Trp Pro Trp Gln Val Ser Leu His Ala Leu Gly Gln Gly His Ile 
625                 630                 635                 640 


Cys Gly Ala Ser Leu Ile Ser Pro Asn Trp Leu Val Ser Ala Ala His 
                645                 650                 655     


Cys Tyr Ile Asp Asp Arg Gly Phe Arg Tyr Ser Asp Pro Thr Gln Trp 
            660                 665                 670         


Thr Ala Phe Leu Gly Leu His Asp Gln Ser Gln Arg Ser Ala Pro Gly 
        675                 680                 685             


Val Gln Glu Arg Arg Leu Lys Arg Ile Ile Ser His Pro Phe Phe Asn 
    690                 695                 700                 


Asp Phe Thr Phe Asp Tyr Asp Ile Ala Leu Leu Glu Leu Glu Lys Pro 
705                 710                 715                 720 


Ala Glu Tyr Ser Ser Met Val Arg Pro Ile Cys Leu Pro Asp Ala Ser 
                725                 730                 735     


His Val Phe Pro Ala Gly Lys Ala Ile Trp Val Thr Gly Trp Gly His 
            740                 745                 750         


Thr Gln Tyr Gly Gly Thr Gly Ala Leu Ile Leu Gln Lys Gly Glu Ile 
        755                 760                 765             


Arg Val Ile Asn Gln Thr Thr Cys Glu Asn Leu Leu Pro Gln Gln Ile 
    770                 775                 780                 


Thr Pro Arg Met Met Cys Val Gly Phe Leu Ser Gly Gly Val Asp Ser 
785                 790                 795                 800 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Ser Ser Val Glu Ala Asp Gly 
                805                 810                 815     


Arg Ile Phe Gln Ala Gly Val Val Ser Trp Gly Asp Gly Cys Ala Gln 
            820                 825                 830         


Arg Asn Lys Pro Gly Val Tyr Thr Arg Leu Pro Leu Phe Arg Asp Trp 
        835                 840                 845             


Ile Lys Glu Asn Thr Gly Val 
    850                 855 


<210>  3
<211>  855
<212>  PRT
<213>  Mus musculus

<400>  3

Met Gly Ser Asn Arg Gly Arg Lys Ala Gly Gly Gly Ser Gln Asp Phe 
1               5                   10                  15      


Gly Ala Gly Leu Lys Tyr Asn Ser Arg Leu Glu Asn Met Asn Gly Phe 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu Pro Ala Asn Asn Ala Lys Lys Val Glu 
        35                  40                  45              


Lys Arg Gly Pro Arg Arg Trp Val Val Leu Val Ala Val Leu Phe Ser 
    50                  55                  60                  


Phe Leu Leu Leu Ser Leu Met Ala Gly Leu Leu Val Trp His Phe His 
65                  70                  75                  80  


Tyr Arg Asn Val Arg Val Gln Lys Val Phe Asn Gly His Leu Arg Ile 
                85                  90                  95      


Thr Asn Glu Ile Phe Leu Asp Ala Tyr Glu Asn Ser Thr Ser Thr Glu 
            100                 105                 110         


Phe Ile Ser Leu Ala Ser Gln Val Lys Glu Ala Leu Lys Leu Leu Tyr 
        115                 120                 125             


Asn Glu Val Pro Val Leu Gly Pro Tyr His Lys Lys Ser Ala Val Thr 
    130                 135                 140                 


Ala Phe Ser Glu Gly Ser Val Ile Ala Tyr Tyr Trp Ser Glu Phe Ser 
145                 150                 155                 160 


Ile Pro Pro His Leu Ala Glu Glu Val Asp Arg Ala Met Ala Val Glu 
                165                 170                 175     


Arg Val Val Thr Leu Pro Pro Arg Ala Arg Ala Leu Lys Ser Phe Val 
            180                 185                 190         


Leu Thr Ser Val Val Ala Phe Pro Ile Asp Pro Arg Met Leu Gln Arg 
        195                 200                 205             


Thr Gln Asp Asn Ser Cys Ser Phe Ala Leu His Ala His Gly Ala Ala 
    210                 215                 220                 


Val Thr Arg Phe Thr Thr Pro Gly Phe Pro Asn Ser Pro Tyr Pro Ala 
225                 230                 235                 240 


His Ala Arg Cys Gln Trp Val Leu Arg Gly Asp Ala Asp Ser Val Leu 
                245                 250                 255     


Ser Leu Thr Phe Arg Ser Phe Asp Val Ala Pro Cys Asp Glu His Gly 
            260                 265                 270         


Ser Asp Leu Val Thr Val Tyr Asp Ser Leu Ser Pro Met Glu Pro His 
        275                 280                 285             


Ala Val Val Arg Leu Cys Gly Thr Phe Ser Pro Ser Tyr Asn Leu Thr 
    290                 295                 300                 


Phe Leu Ser Ser Gln Asn Val Phe Leu Val Thr Leu Ile Thr Asn Thr 
305                 310                 315                 320 


Asp Arg Arg His Pro Gly Phe Glu Ala Thr Phe Phe Gln Leu Pro Lys 
                325                 330                 335     


Met Ser Ser Cys Gly Gly Phe Leu Ser Asp Thr Gln Gly Thr Phe Ser 
            340                 345                 350         


Ser Pro Tyr Tyr Pro Gly His Tyr Pro Pro Asn Ile Asn Cys Thr Trp 
        355                 360                 365             


Asn Ile Lys Val Pro Asn Asn Arg Asn Val Lys Val Arg Phe Lys Leu 
    370                 375                 380                 


Phe Tyr Leu Val Asp Pro Asn Val Pro Val Gly Ser Cys Thr Lys Asp 
385                 390                 395                 400 


Tyr Val Glu Ile Asn Gly Glu Lys Tyr Cys Gly Glu Arg Ser Gln Phe 
                405                 410                 415     


Val Val Ser Ser Asn Ser Ser Lys Ile Thr Val His Phe His Ser Asp 
            420                 425                 430         


His Ser Tyr Thr Asp Thr Gly Phe Leu Ala Glu Tyr Leu Ser Tyr Asp 
        435                 440                 445             


Ser Asn Asp Pro Cys Pro Gly Met Phe Met Cys Lys Thr Gly Arg Cys 
    450                 455                 460                 


Ile Arg Lys Glu Leu Arg Cys Asp Gly Trp Ala Asp Cys Pro Asp Tyr 
465                 470                 475                 480 


Ser Asp Glu Arg Tyr Cys Arg Cys Asn Ala Thr His Gln Phe Thr Cys 
                485                 490                 495     


Lys Asn Gln Phe Cys Lys Pro Leu Phe Trp Val Cys Asp Ser Val Asn 
            500                 505                 510         


Asp Cys Gly Asp Gly Ser Asp Glu Glu Gly Cys Ser Cys Pro Ala Gly 
        515                 520                 525             


Ser Phe Lys Cys Ser Asn Gly Lys Cys Leu Pro Gln Ser Gln Lys Cys 
    530                 535                 540                 


Asn Gly Lys Asp Asn Cys Gly Asp Gly Ser Asp Glu Ala Ser Cys Asp 
545                 550                 555                 560 


Ser Val Asn Val Val Ser Cys Thr Lys Tyr Thr Tyr Arg Cys Gln Asn 
                565                 570                 575     


Gly Leu Cys Leu Ser Lys Gly Asn Pro Glu Cys Asp Gly Lys Thr Asp 
            580                 585                 590         


Cys Ser Asp Gly Ser Asp Glu Lys Asn Cys Asp Cys Gly Leu Arg Ser 
        595                 600                 605             


Phe Thr Lys Gln Ala Arg Val Val Gly Gly Thr Asn Ala Asp Glu Gly 
    610                 615                 620                 


Glu Trp Pro Trp Gln Val Ser Leu His Ala Leu Gly Gln Gly His Leu 
625                 630                 635                 640 


Cys Gly Ala Ser Leu Ile Ser Pro Asp Trp Leu Val Ser Ala Ala His 
                645                 650                 655     


Cys Phe Gln Asp Asp Lys Asn Phe Lys Tyr Ser Asp Tyr Thr Met Trp 
            660                 665                 670         


Thr Ala Phe Leu Gly Leu Leu Asp Gln Ser Lys Arg Ser Ala Ser Gly 
        675                 680                 685             


Val Gln Glu Leu Lys Leu Lys Arg Ile Ile Thr His Pro Ser Phe Asn 
    690                 695                 700                 


Asp Phe Thr Phe Asp Tyr Asp Ile Ala Leu Leu Glu Leu Glu Lys Ser 
705                 710                 715                 720 


Val Glu Tyr Ser Thr Val Val Arg Pro Ile Cys Leu Pro Asp Ala Thr 
                725                 730                 735     


His Val Phe Pro Ala Gly Lys Ala Ile Trp Val Thr Gly Trp Gly His 
            740                 745                 750         


Thr Lys Glu Gly Gly Thr Gly Ala Leu Ile Leu Gln Lys Gly Glu Ile 
        755                 760                 765             


Arg Val Ile Asn Gln Thr Thr Cys Glu Asp Leu Met Pro Gln Gln Ile 
    770                 775                 780                 


Thr Pro Arg Met Met Cys Val Gly Phe Leu Ser Gly Gly Val Asp Ser 
785                 790                 795                 800 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Ser Ser Ala Glu Lys Asp Gly 
                805                 810                 815     


Arg Met Phe Gln Ala Gly Val Val Ser Trp Gly Glu Gly Cys Ala Gln 
            820                 825                 830         


Arg Asn Lys Pro Gly Val Tyr Thr Arg Leu Pro Val Val Arg Asp Trp 
        835                 840                 845             


Ile Lys Glu His Thr Gly Val 
    850                 855 


<210>  4
<211>  855
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Gly Asn Asn Arg Gly Arg Lys Ala Gly Gly Gly Ser Gln Asp Phe 
1               5                   10                  15      


Gly Ala Gly Leu Lys Tyr Asn Ser Arg Leu Glu Asn Met Asn Gly Phe 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu Pro Val Asn Asn Ala Lys Gln Val Glu 
        35                  40                  45              


Lys Arg Gly Pro Arg Arg Trp Val Val Met Val Ala Val Val Phe Ser 
    50                  55                  60                  


Phe Leu Leu Leu Ser Leu Met Ala Gly Leu Leu Val Trp His Phe His 
65                  70                  75                  80  


Tyr Arg Asn Val Arg Ile Gln Lys Val Phe Asn Gly His Leu Arg Ile 
                85                  90                  95      


Thr Asn Glu Asn Phe Leu Asp Ala Tyr Glu Asn Ser Thr Ser Thr Glu 
            100                 105                 110         


Phe Ile Ser Leu Ala Ser Gln Val Lys Glu Ala Leu Lys Leu Met Tyr 
        115                 120                 125             


Ser Glu Val Pro Val Leu Gly Pro Tyr His Lys Lys Ser Thr Val Thr 
    130                 135                 140                 


Ala Phe Ser Glu Gly Ser Val Ile Ala Tyr Tyr Trp Ser Glu Phe Ser 
145                 150                 155                 160 


Ile Pro Pro His Leu Glu Glu Glu Val Asp Arg Ala Met Ala Val Glu 
                165                 170                 175     


Arg Val Val Thr Leu Pro Pro Arg Ala Arg Ala Leu Lys Ser Phe Val 
            180                 185                 190         


Leu Thr Ser Val Val Ala Phe Pro Ile Asp Pro Arg Met Leu Gln Arg 
        195                 200                 205             


Thr Gln Asp Asn Ser Cys Ser Phe Ala Leu His Ala Arg Gly Arg Thr 
    210                 215                 220                 


Val Thr Arg Phe Thr Thr Pro Gly Phe Pro Asn Ser Pro Tyr Pro Ala 
225                 230                 235                 240 


His Ala Arg Cys Gln Trp Val Leu Arg Gly Asp Ala Asp Ser Val Leu 
                245                 250                 255     


Ser Leu Thr Phe Arg Ser Phe Asp Val Ala Pro Cys Asp Gly His Asp 
            260                 265                 270         


Ser Asp Leu Val Thr Val Tyr Asp Ser Leu Ser Pro Met Glu Pro His 
        275                 280                 285             


Ala Val Val Arg Leu Cys Gly Thr Phe Ser Pro Ser Tyr Asn Leu Thr 
    290                 295                 300                 


Phe Leu Ser Ser Gln Asn Val Phe Leu Val Thr Leu Ile Thr Asn Thr 
305                 310                 315                 320 


Asp Arg Arg His Pro Gly Phe Glu Ala Thr Phe Phe Gln Leu Pro Lys 
                325                 330                 335     


Met Ser Ser Cys Gly Gly Leu Leu Ser Glu Ala Gln Gly Thr Phe Ser 
            340                 345                 350         


Ser Pro Tyr Tyr Pro Gly His Tyr Pro Pro Asn Ile Asn Cys Thr Trp 
        355                 360                 365             


Asn Ile Lys Val Pro Asn Asn Arg Asn Val Lys Val Arg Phe Lys Leu 
    370                 375                 380                 


Phe Tyr Leu Val Asp Pro Asn Ile Pro Val Gly Ser Cys Thr Lys Asp 
385                 390                 395                 400 


Tyr Val Glu Ile Asn Gly Glu Lys Phe Cys Gly Glu Arg Ser Gln Phe 
                405                 410                 415     


Val Val Ser Ser Asn Ser Ser Lys Ile Thr Val His Phe His Ser Asp 
            420                 425                 430         


His Ser Tyr Thr Asp Thr Gly Phe Leu Ala Glu Tyr Leu Ser Tyr Asp 
        435                 440                 445             


Ser Asn Asp Pro Cys Pro Gly Met Phe Met Cys Lys Thr Gly Arg Cys 
    450                 455                 460                 


Ile Arg Lys Asp Leu Arg Cys Asp Gly Trp Ala Asp Cys Pro Asp Tyr 
465                 470                 475                 480 


Ser Asp Glu Arg His Cys Arg Cys Asn Ala Thr His Gln Phe Met Cys 
                485                 490                 495     


Lys Asn Gln Phe Cys Lys Pro Leu Phe Trp Val Cys Asp Ser Val Asn 
            500                 505                 510         


Asp Cys Gly Asp Gly Ser Asp Glu Glu Gly Cys Ser Cys Pro Ala Gly 
        515                 520                 525             


Ser Phe Lys Cys Ser Asn Gly Lys Cys Leu Pro Gln Ser Gln Gln Cys 
    530                 535                 540                 


Asn Gly Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu Ala Ser Cys Asp 
545                 550                 555                 560 


Asn Val Asn Ala Val Ser Cys Thr Lys Tyr Thr Tyr Arg Cys Gln Asn 
                565                 570                 575     


Gly Leu Cys Leu Asn Lys Gly Asn Pro Glu Cys Asp Gly Lys Lys Asp 
            580                 585                 590         


Cys Ser Asp Gly Ser Asp Glu Lys Asn Cys Asp Cys Gly Leu Arg Ser 
        595                 600                 605             


Phe Thr Lys Gln Ala Arg Val Val Gly Gly Thr Asn Ala Asp Glu Gly 
    610                 615                 620                 


Glu Trp Pro Trp Gln Val Ser Leu His Ala Leu Gly Gln Gly His Leu 
625                 630                 635                 640 


Cys Gly Ala Ser Leu Ile Ser Pro Asp Trp Leu Val Ser Ala Ala His 
                645                 650                 655     


Cys Phe Gln Asp Glu Thr Ile Phe Lys Tyr Ser Asp His Thr Met Trp 
            660                 665                 670         


Thr Ala Phe Leu Gly Leu Leu Asp Gln Ser Lys Arg Ser Ala Ser Gly 
        675                 680                 685             


Val Gln Glu His Lys Leu Lys Arg Ile Ile Thr His Pro Ser Phe Asn 
    690                 695                 700                 


Asp Phe Thr Phe Asp Tyr Asp Ile Ala Leu Leu Glu Leu Glu Lys Pro 
705                 710                 715                 720 


Ala Glu Tyr Ser Thr Val Val Arg Pro Ile Cys Leu Pro Asp Asn Thr 
                725                 730                 735     


His Val Phe Pro Ala Gly Lys Ala Ile Trp Val Thr Gly Trp Gly His 
            740                 745                 750         


Thr Lys Glu Gly Gly Thr Gly Ala Leu Ile Leu Gln Lys Gly Glu Ile 
        755                 760                 765             


Arg Val Ile Asn Gln Thr Thr Cys Glu Glu Leu Leu Pro Gln Gln Ile 
    770                 775                 780                 


Thr Pro Arg Met Met Cys Val Gly Phe Leu Ser Gly Gly Val Asp Ser 
785                 790                 795                 800 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Ser Ser Val Glu Lys Asp Gly 
                805                 810                 815     


Arg Ile Phe Gln Ala Gly Val Val Ser Trp Gly Glu Gly Cys Ala Gln 
            820                 825                 830         


Arg Asn Lys Pro Gly Val Tyr Thr Arg Ile Pro Glu Val Arg Asp Trp 
        835                 840                 845             


Ile Lys Glu Gln Thr Gly Val 
    850                 855 


<210>  5
<211>  855
<212>  PRT
<213>  Pan troglodytes


<220>
<221>  misc_feature
<222>  (561)..(561)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Met Gly Ser Asp Arg Ala Arg Lys Gly Gly Gly Gly Pro Lys Asp Phe 
1               5                   10                  15      


Gly Ala Gly Leu Lys Tyr Asn Ser Arg His Glu Lys Val Asn Gly Leu 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu Pro Val Asn Asn Val Lys Lys Val Glu 
        35                  40                  45              


Lys His Gly Pro Gly Arg Trp Val Val Leu Ala Ala Val Leu Ile Gly 
    50                  55                  60                  


Leu Leu Leu Val Leu Leu Gly Ile Gly Phe Leu Val Trp His Leu Gln 
65                  70                  75                  80  


Tyr Arg Asp Val Arg Val Gln Lys Val Phe Asn Gly Tyr Met Arg Ile 
                85                  90                  95      


Thr Asn Glu Asn Phe Val Asp Ala Tyr Glu Asn Ser Asn Ser Thr Glu 
            100                 105                 110         


Phe Val Ser Leu Ala Ser Lys Val Lys Asp Ala Leu Lys Leu Leu Tyr 
        115                 120                 125             


Ser Gly Val Pro Phe Leu Gly Pro Tyr His Lys Glu Ser Ala Val Thr 
    130                 135                 140                 


Ala Phe Ser Glu Gly Ser Val Ile Ala Tyr Tyr Trp Ser Glu Phe Ser 
145                 150                 155                 160 


Ile Pro Gln His Leu Val Glu Glu Ala Glu Arg Val Met Ala Glu Glu 
                165                 170                 175     


Arg Val Val Met Leu Pro Pro Arg Ala Arg Ser Leu Lys Ser Phe Val 
            180                 185                 190         


Val Thr Ser Val Val Ala Phe Pro Thr Asp Ser Lys Thr Val Gln Arg 
        195                 200                 205             


Thr Gln Asp Asn Ser Cys Ser Phe Gly Leu His Ala Arg Gly Val Glu 
    210                 215                 220                 


Leu Met Arg Phe Thr Thr Pro Gly Phe Pro Asp Ser Pro Tyr Pro Ala 
225                 230                 235                 240 


His Ala Arg Cys Gln Trp Ala Leu Arg Gly Asp Ala Asp Ser Val Leu 
                245                 250                 255     


Ser Leu Thr Phe Arg Ser Phe Asp Leu Ala Ser Cys Asp Glu Arg Gly 
            260                 265                 270         


Ser Asp Leu Val Met Val Tyr Asn Thr Leu Ser Pro Met Glu Pro His 
        275                 280                 285             


Ala Leu Val Gln Leu Cys Gly Thr Tyr Pro Pro Ser Tyr Asn Leu Thr 
    290                 295                 300                 


Phe His Ser Ser Gln Asn Val Leu Leu Val Thr Leu Ile Thr Asn Thr 
305                 310                 315                 320 


Arg Arg Arg His Pro Gly Phe Glu Ala Thr Phe Phe Gln Leu Pro Arg 
                325                 330                 335     


Met Arg Ser Cys Gly Gly Arg Leu Arg Lys Ala Gln Gly Thr Phe Asn 
            340                 345                 350         


Ser Pro Tyr Tyr Pro Gly His Tyr Pro Pro Asn Ile Asp Cys Thr Trp 
        355                 360                 365             


Asn Ile Glu Val Pro Asn Asn Gln His Val Lys Val Arg Phe Lys Phe 
    370                 375                 380                 


Phe Tyr Leu Leu Glu Pro Gly Val Pro Ala Gly Thr Cys Pro Lys Asp 
385                 390                 395                 400 


Tyr Val Glu Ile Asn Gly Glu Lys Tyr Cys Gly Glu Arg Ser Gln Phe 
                405                 410                 415     


Val Val Thr Ser Asn Ser Asn Lys Ile Thr Val Arg Phe His Ser Asp 
            420                 425                 430         


Gln Ser Tyr Thr Asp Thr Gly Phe Leu Ala Glu Tyr Val Ser Tyr Asp 
        435                 440                 445             


Ser Ser Asp Pro Cys Pro Gly Gln Phe Thr Cys Arg Thr Gly Arg Cys 
    450                 455                 460                 


Ile Arg Lys Glu Leu Arg Cys Asp Gly Trp Ala Asp Cys Thr Asp His 
465                 470                 475                 480 


Ser Asp Glu Leu Asn Cys Ser Cys Asp Ala Ser His Gln Phe Thr Cys 
                485                 490                 495     


Lys Asn Lys Phe Cys Lys Pro Leu Phe Trp Val Cys Asp Ser Val Asn 
            500                 505                 510         


Asp Cys Gly Asp Asn Ser Asp Glu Gln Gly Cys Ser Cys Pro Ala Gln 
        515                 520                 525             


Thr Phe Arg Cys Ser Asn Gly Lys Cys Leu Ser Lys Ser Gln Gln Cys 
    530                 535                 540                 


Asn Gly Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu Ala Ser Cys Pro 
545                 550                 555                 560 


Xaa Val Asn Val Val Thr Cys Thr Lys His Thr Tyr Arg Cys Leu Asn 
                565                 570                 575     


Gly Leu Cys Leu Ser Lys Gly Asn Pro Glu Cys Asp Gly Lys Glu Asp 
            580                 585                 590         


Cys Ser Asp Gly Ser Asp Glu Lys Asp Cys Asp Cys Gly Leu Arg Ser 
        595                 600                 605             


Phe Thr Arg Gln Ala Arg Val Val Gly Gly Thr Asp Ala Asp Glu Gly 
    610                 615                 620                 


Glu Trp Pro Trp Gln Val Ser Leu His Ala Leu Gly Gln Gly His Ile 
625                 630                 635                 640 


Cys Gly Ala Ser Leu Ile Ser Pro Asn Trp Leu Val Ser Ala Ala His 
                645                 650                 655     


Cys Tyr Ile Asp Asp Arg Gly Phe Arg Tyr Ser Asp Pro Thr Gln Trp 
            660                 665                 670         


Thr Ala Phe Leu Gly Leu His Asp Gln Ser Gln Arg Ser Ala Pro Gly 
        675                 680                 685             


Val Gln Glu Arg Arg Leu Lys Arg Ile Ile Ser His Pro Phe Phe Asn 
    690                 695                 700                 


Asp Phe Thr Phe Asp Tyr Asp Ile Ala Leu Leu Glu Leu Glu Lys Pro 
705                 710                 715                 720 


Ala Glu Tyr Ser Ser Met Val Arg Pro Ile Cys Leu Pro Asp Ala Ser 
                725                 730                 735     


His Val Phe Pro Ala Gly Lys Ala Ile Trp Val Thr Gly Trp Gly His 
            740                 745                 750         


Thr Gln Tyr Gly Gly Thr Gly Ala Leu Ile Leu Gln Lys Gly Glu Ile 
        755                 760                 765             


Arg Val Ile Asn Gln Thr Thr Cys Glu Asn Leu Leu Pro Gln Gln Ile 
    770                 775                 780                 


Thr Pro Arg Met Met Cys Val Gly Phe Leu Ser Gly Gly Val Asp Ser 
785                 790                 795                 800 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Ser Ser Val Glu Ala Asp Gly 
                805                 810                 815     


Arg Ile Phe Gln Ala Gly Val Val Ser Trp Gly Asp Gly Cys Ala Gln 
            820                 825                 830         


Arg Asn Lys Pro Gly Val Tyr Thr Arg Leu Pro Leu Phe Arg Asp Trp 
        835                 840                 845             


Ile Lys Glu Asn Thr Gly Val 
    850                 855 


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Matriptase/MT-SP1 - sense sequence of siRNA

<400>  6
gcaagaucac uguucgcuut t                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Matriptase/MT-SP1 Antisense sequence of siRNA

<400>  7
aagcgaacag ugaucuugct g                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1ra - Sense sequence of siRNA

<400>  8
gaugucuuuu cucaaaauat t                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1ra - Antisense sequence of siRNA

<400>  9
uauuuugaga aaagacauca t                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gm5077 - sense sequence of siRNA

<400>  10
cgcugaacgu gugauuauut t                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gm5077 - Antisense sequence of siRNA

<400>  11
aauaaucaca cguucagcgg t                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plat - Sense sequence of siRNA

<400>  12
gaaacaagau gaagacagat t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plat - Antisense sequence of siRNA

<400>  13
ucugucuuca ucuuguuucc c                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Prss35 - Sense sequence of siRNA

<400>  14
ggccuuagac uacgacuaut t                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Prss35 - Antisense sequence of siRNA

<400>  15
auagucguag ucuaaggccg g                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Matriptase/MT-SP1 - Forward Primer Sequence

<400>  16
cgctgagtac ctgtcctacg a                                                 21


<210>  17
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Matriptase/MT-SP1 - Reverse Primer Sequence

<400>  17
accgtccagt gttacacatg aac                                               23


<210>  18
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Matriptase/MT-SP1 Reporter 1 Sequence

<400>  18
ccaatgaccc atgccc                                                       16


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1ra Forward Primer Sequence

<400>  19
acctgcaaac aaggctacca                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1ra Reverse Primer Sequence

<400>  20
tggcaaacag ctgtgaagga                                                   20


<210>  21
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1ra Reporter 1 Sequence

<400>  21
cagcacctgg tttcc                                                        15


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gm5077 Forward Primer Sequence

<400>  22
tgcgaggagc catattacta catg                                              24


<210>  23
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gm5077 Reverse Primer Sequence

<400>  23
gcagcgcagc gatactc                                                      17


<210>  24
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gm5077 Reporter 1 Sequence

<400>  24
ccgccgtgtt cttcat                                                       16


<210>  25
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plat Forward Primer Sequence

<400>  25
agctgacatg ggaatactgt gatg                                              24


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plat Reverse Primer Sequence

<400>  26
cctttaattc gaaactgtgg ctgtt                                             25


<210>  27
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plat Reporter 1 Sequence

<400>  27
ccgtgctcca cctgc                                                        15


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Prss35 Forward Primer Sequence

<400>  28
aggagagcac cacacaaaga c                                                 21


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Prss35 Reverse Primer Sequence

<400>  29
acacgagtcc actggaagga                                                   20


<210>  30
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Prss35 Reporter 1 Sequence

<400>  30
ccccggaccc ctcctg                                                       16


<210>  31
<211>  345
<212>  DNA
<213>  Cricetulus griseus

<400>  31
ttttttgccc agtcctggtt cttccaaact cacaggtgtc actgaacctc cggggctggg       60

aagctattgt cggggagcgt ctctgagtcc tgaaatatct ttctgtttag aacatgaatg      120

gctttgagga gggtgtggag tttctgcctg tgaataatgc caagaaagtg gagaagcgag      180

gcccccggcg ctgtgtggtg cttgtggtcc tgctggtcag tttcctcttt ctctcactcg      240

tggctggctt cctggtgtgg cacttcctct gtgagtacag tgggggctgt gggagggcga      300

cagaggggta gtgttctctc ttctctcaga ggacagacca aaggg                      345


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer Sequence

<400>  32
ttttttgccc agtcctggtt                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer Sequence

<400>  33
ccctttggtc tgtcctctga                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cut. Primer

<400>  34
gtggagtttc tgcctgtgaa                                                   20


<210>  35
<211>  160
<212>  DNA
<213>  Cricetulus griseus

<400>  35
aacatgaatg gctttgagga gggtgtggag tttctgcctg tgaataatgc caagaaagtg       60

gagaagcgag gcccccggcg ctgtgtggtg cttgtggtcc tgctggtcag tttcctcttt      120

ctctcactcg tggctggctt cctggtgtgg cacttcctct                            160


<210>  36
<211>  156
<212>  DNA
<213>  Cricetulus griseus

<400>  36
aacatgaatg gctttgagga gggtgtggag ttcctgtgaa taatgccaag aaagtggaga       60

agcgaggccc ccggcgctgt gtggtgcttg tggtcctgct ggtcagtttc ctctttctct      120

cactcgtggc tggcttcctg gtgtggcact tcctct                                156


<210>  37
<211>  156
<212>  DNA
<213>  Cricetulus griseus

<400>  37
aacatgaatg gctttgagga gggtgtggag tttctgtgaa taatgccaag aaagtggaga       60

agcgaggccc ccggcgctgt gtggtgcttg tggtcctgct ggtcagtttc ctctttctct      120

cactcgtggc tggcttcctg gtgtggcact tcctct                                156


<210>  38
<211>  143
<212>  DNA
<213>  Cricetulus griseus

<400>  38
aacatgaatg gctttgagga gggtgaataa tgccaagaaa gtggagaagc gaggcccccg       60

gcgctgtgtg gtgcttgtgg tcctgctggt cagtttcctc tttctctcac tcgtggctgg      120

cttcctggtg tggcacttcc tct                                              143


<210>  39
<211>  17
<212>  DNA
<213>  Cricetulus griseus

<400>  39
tggagtttct gcctgtg                                                      17


<210>  40
<211>  146
<212>  DNA
<213>  Cricetulus griseus

<400>  40
aacatgaatg gctttgagga gggtgtggaa taatgccaag aaagtggaga agcgaggccc       60

ccggcgctgt gtggtgcttg tggtcctgct ggtcagtttc ctctttctct cactcgtggc      120

tggcttcctg gtgtggcact tcctct                                           146


<210>  41
<211>  14
<212>  DNA
<213>  Cricetulus griseus

<400>  41
gtttctgcct gtga                                                         14


<210>  42
<211>  156
<212>  DNA
<213>  Cricetulus griseus

<400>  42
aacatgaatg gctttgagga gggtgtggag tgcctgtgaa taatgccaag aaagtggaga       60

agcgaggccc ccggcgctgt gtggtgcttg tggtcctgct ggtcagtttc ctctttctct      120

cactcgtggc tggcttcctg gtgtggcact tcctct                                156


<210>  43
<211>  149
<212>  DNA
<213>  Cricetulus griseus

<400>  43
aacatgaatg gctttgagga gggtgtggag taataatgcc aagaaagtgg agaagcgagg       60

cccccggcgc tgtgtggtgc ttgtggtcct gctggtcagt ttcctctttc tctcactcgt      120

ggctggcttc ctggtgtggc acttcctct                                        149


<210>  44
<211>  11
<212>  DNA
<213>  Cricetulus griseus

<400>  44
ttctgcctgt g                                                            11


<210>  45
<211>  153
<212>  DNA
<213>  Cricetulus griseus

<400>  45
aacatgaatg gctttgagga gggtgtgggc ctgtgaataa tgccaagaaa gtggagaagc       60

gaggcccccg gcgctgtgtg gtgcttgtgg tcctgctggt cagtttcctc tttctctcac      120

tcgtggctgg cttcctggtg tggcacttcc tct                                   153


<210>  46
<211>  145
<212>  DNA
<213>  Cricetulus griseus

<400>  46
aacatgaatg gctttgagga gggtgtgaat aatgccaaga aagtggagaa gcgaggcccc       60

cggcgctgtg tggtgcttgt ggtcctgctg gtcagtttcc tctttctctc actcgtggct      120

ggcttcctgg tgtggcactt cctct                                            145


<210>  47
<211>  15
<212>  DNA
<213>  Cricetulus griseus

<400>  47
gagtttctgc ctgtg                                                        15


<210>  48
<211>  124
<212>  PRT
<213>  Cricetulus griseus

<400>  48

Met Gly Ser Asn Arg Gly Arg Lys Ala Gly Gly Ser Ser Lys Asp Phe 
1               5                   10                  15      


Gly Ala Arg Leu Lys Tyr Ser Ser Gly Leu Glu Asn Met Asn Gly Phe 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu Pro Val Asn Asn Ala Lys Lys Val Glu 
        35                  40                  45              


Lys Arg Gly Pro Arg Arg Cys Val Val Leu Val Val Leu Leu Val Ser 
    50                  55                  60                  


Phe Leu Phe Leu Ser Leu Val Ala Gly Phe Leu Val Trp His Phe Leu 
65                  70                  75                  80  


Tyr Ser Asn Val Arg Ile Gln Lys Val Phe Asn Gly His Leu Arg Val 
                85                  90                  95      


Thr Asn Glu Asn Phe Leu Asp Ala Tyr Glu Asn Ser Asn Ser Thr Glu 
            100                 105                 110         


Phe Lys Asp Leu Ala Asn Gln Val Lys Glu Ala Leu 
        115                 120                 


<210>  49
<211>  39
<212>  PRT
<213>  Cricetulus griseus

<400>  49

Met Gly Ser Asn Arg Gly Arg Lys Ala Gly Gly Ser Ser Lys Asp Phe 
1               5                   10                  15      


Gly Ala Arg Leu Lys Tyr Ser Ser Gly Leu Glu Asn Met Asn Gly Phe 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu 
        35                  


<210>  50
<211>  52
<212>  PRT
<213>  Cricetulus griseus

<400>  50

Ile Met Pro Arg Lys Trp Arg Ser Glu Ala Pro Gly Ala Val Trp Cys 
1               5                   10                  15      


Leu Trp Ser Cys Trp Ser Val Ser Ser Phe Ser His Ser Trp Leu Ala 
            20                  25                  30          


Ser Trp Cys Gly Thr Ser Ser Thr Gln Met Phe Gly Ser Lys Arg Ser 
        35                  40                  45              


Ser Met Val Ile 
    50          


<210>  51
<211>  25
<212>  PRT
<213>  Cricetulus griseus

<400>  51

Gly Ser Gln Met Arg Thr Phe Trp Met Pro Met Arg Thr Gln Thr Pro 
1               5                   10                  15      


Gln Ser Ser Lys Thr Trp Pro Thr Arg 
            20                  25  


<210>  52
<211>  39
<212>  PRT
<213>  Cricetulus griseus

<400>  52

Met Gly Ser Asn Arg Gly Arg Lys Ala Gly Gly Ser Ser Lys Asp Phe 
1               5                   10                  15      


Gly Ala Arg Leu Lys Tyr Ser Ser Gly Leu Glu Asn Met Asn Gly Phe 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu 
        35                  


<210>  53
<211>  52
<212>  PRT
<213>  Cricetulus griseus

<400>  53

Ile Met Pro Arg Lys Trp Arg Ser Glu Ala Pro Gly Ala Val Trp Cys 
1               5                   10                  15      


Leu Trp Ser Cys Trp Ser Val Ser Ser Phe Ser His Ser Trp Leu Ala 
            20                  25                  30          


Ser Trp Cys Gly Thr Ser Ser Thr Gln Met Phe Gly Ser Lys Arg Ser 
        35                  40                  45              


Ser Met Val Ile 
    50          


<210>  54
<211>  25
<212>  PRT
<213>  Cricetulus griseus

<400>  54

Gly Ser Gln Met Arg Thr Phe Trp Met Pro Met Arg Thr Gln Thr Pro 
1               5                   10                  15      


Gln Ser Ser Lys Thr Trp Pro Thr Arg 
            20                  25  


<210>  55
<211>  36
<212>  PRT
<213>  Cricetulus griseus

<400>  55

Met Gly Ser Asn Arg Gly Arg Lys Ala Gly Gly Ser Ser Lys Asp Phe 
1               5                   10                  15      


Gly Ala Arg Leu Lys Tyr Ser Ser Gly Leu Glu Asn Met Asn Gly Phe 
            20                  25                  30          


Glu Glu Gly Glu 
        35      


<210>  56
<211>  55
<212>  PRT
<213>  Cricetulus griseus

<400>  56

Cys Gln Glu Ser Gly Glu Ala Arg Pro Pro Ala Leu Cys Gly Ala Cys 
1               5                   10                  15      


Gly Pro Ala Gly Gln Phe Pro Leu Ser Leu Thr Arg Gly Trp Leu Pro 
            20                  25                  30          


Gly Val Ala Leu Pro Leu Leu Lys Cys Ser Asp Pro Lys Gly Leu Gln 
        35                  40                  45              


Trp Ser Ser Glu Gly His Lys 
    50                  55  


<210>  57
<211>  6
<212>  PRT
<213>  Cricetulus griseus

<400>  57

Glu Leu Ser Gly Cys Leu 
1               5       


<210>  58
<211>  23
<212>  PRT
<213>  Cricetulus griseus

<400>  58

Glu Leu Lys Leu His Arg Val Gln Arg Pro Gly Gln Pro Gly Glu Gly 
1               5                   10                  15      


Ser Ala Glu Ala Val Val Gln 
            20              


<210>  59
<211>  37
<212>  PRT
<213>  Cricetulus griseus

<400>  59

Met Gly Ser Asn Arg Gly Arg Lys Ala Gly Gly Ser Ser Lys Asp Phe 
1               5                   10                  15      


Gly Ala Arg Leu Lys Tyr Ser Ser Gly Leu Glu Asn Met Asn Gly Phe 
            20                  25                  30          


Glu Glu Gly Val Glu 
        35          


<210>  60
<211>  55
<212>  PRT
<213>  Cricetulus griseus

<400>  60

Cys Gln Glu Ser Gly Glu Ala Arg Pro Pro Ala Leu Cys Gly Ala Cys 
1               5                   10                  15      


Gly Pro Ala Gly Gln Phe Pro Leu Ser Leu Thr Arg Gly Trp Leu Pro 
            20                  25                  30          


Gly Val Ala Leu Pro Leu Leu Lys Cys Ser Asp Pro Lys Gly Leu Gln 
        35                  40                  45              


Trp Ser Ser Glu Gly His Lys 
    50                  55  


<210>  61
<211>  6
<212>  PRT
<213>  Cricetulus griseus

<400>  61

Glu Leu Ser Gly Cys Leu 
1               5       


<210>  62
<211>  23
<212>  PRT
<213>  Cricetulus griseus

<400>  62

Glu Leu Lys Leu His Arg Val Gln Arg Pro Gly Gln Pro Gly Glu Gly 
1               5                   10                  15      


Ser Ala Glu Ala Val Val Gln 
            20              


<210>  63
<211>  39
<212>  PRT
<213>  Cricetulus griseus

<400>  63

Met Gly Ser Asn Arg Gly Arg Lys Ala Gly Gly Ser Ser Lys Asp Phe 
1               5                   10                  15      


Gly Ala Arg Leu Lys Tyr Ser Ser Gly Leu Glu Asn Met Asn Gly Phe 
            20                  25                  30          


Glu Glu Gly Val Glu Cys Leu 
        35                  


<210>  64
<211>  52
<212>  PRT
<213>  Cricetulus griseus

<400>  64

Ile Met Pro Arg Lys Trp Arg Ser Glu Ala Pro Gly Ala Val Trp Cys 
1               5                   10                  15      


Leu Trp Ser Cys Trp Ser Val Ser Ser Phe Ser His Ser Trp Leu Ala 
            20                  25                  30          


Ser Trp Cys Gly Thr Ser Ser Thr Gln Met Phe Gly Ser Lys Arg Ser 
        35                  40                  45              


Ser Met Val Ile 
    50          


<210>  65
<211>  25
<212>  PRT
<213>  Cricetulus griseus

<400>  65

Gly Ser Gln Met Arg Thr Phe Trp Met Pro Met Arg Thr Gln Thr Pro 
1               5                   10                  15      


Gln Ser Ser Lys Thr Trp Pro Thr Arg 
            20                  25  


<210>  66
<211>  37
<212>  PRT
<213>  Cricetulus griseus

<400>  66

Met Gly Ser Asn Arg Gly Arg Lys Ala Gly Gly Ser Ser Lys Asp Phe 
1               5                   10                  15      


Gly Ala Arg Leu Lys Tyr Ser Ser Gly Leu Glu Asn Met Asn Gly Phe 
            20                  25                  30          


Glu Glu Gly Val Glu 
        35          


<210>  67
<211>  55
<212>  PRT
<213>  Cricetulus griseus

<400>  67

Cys Gln Glu Ser Gly Glu Ala Arg Pro Pro Ala Leu Cys Gly Ala Cys 
1               5                   10                  15      


Gly Pro Ala Gly Gln Phe Pro Leu Ser Leu Thr Arg Gly Trp Leu Pro 
            20                  25                  30          


Gly Val Ala Leu Pro Leu Leu Lys Cys Ser Asp Pro Lys Gly Leu Gln 
        35                  40                  45              


Trp Ser Ser Glu Gly His Lys 
    50                  55  


<210>  68
<211>  6
<212>  PRT
<213>  Cricetulus griseus

<400>  68

Glu Leu Ser Gly Cys Leu 
1               5       


<210>  69
<211>  23
<212>  PRT
<213>  Cricetulus griseus

<400>  69

Glu Leu Lys Leu His Arg Val Gln Arg Pro Gly Gln Pro Gly Glu Gly 
1               5                   10                  15      


Ser Ala Glu Ala Val Val Gln 
            20              


