                         SEQUENCE LISTING

<110>  Pfizer Inc.
       Damelin, Marc
 
<120>  ANTI-PTK7 ANTIBODY-DRUG CONJUGATES

<130>  PC72045

<160>  87    

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  1

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Asn Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Arg Ser Asn Tyr Gly Tyr Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  2
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  2
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcagc actagtaaca tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtggctt gcacacattt ggtgggatga tgataagtac      180

tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgttcgaagt      300

aactatggtt acgcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca      360


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  3

Thr Ser Asn Met Gly Val Gly 
1               5           


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  4

Gly Phe Ser Leu Ser Thr Ser Asn Met 
1               5                   


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  5
actagtaaca tgggtgtggg c                                                 21


<210>  6
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  6
gggttctcac tcagcactag taacatg                                           27


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  7

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  8

Trp Trp Asp Asp Asp 
1               5   


<210>  9
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  9
cacatttggt gggatgatga taagtactac agcccatctc tgaagagc                    48


<210>  10
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  10
tggtgggatg atgat                                                        15


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  11

Ser Asn Tyr Gly Tyr Ala Trp Phe Ala Tyr 
1               5                   10  


<210>  12
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  12
agtaactatg gttacgcctg gtttgcttac                                        30


<210>  13
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  13

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Asn Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Arg Ser Asn Tyr Gly Tyr Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  14
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  14
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcagc actagtaaca tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtggctt gcacacattt ggtgggatga tgataagtac      180

tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgttcgaagt      300

aactatggtt acgcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cgagcaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgagccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggt                                         1347


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Pro Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Thr Asn Arg Leu Leu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  16
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  16
gacatccaga tgacccagtc tccatcttcc ctgtctgcat ctgtaggaga tagagtcact       60

atcacttgca aggcgagtca ggacatttat ccctatttaa actggttcca acaaaaacca      120

gggaaagctc ctaagaccct gatctatcgt acaaatagat tgctagatgg ggtcccatca      180

aggttcagtg gcagtggatc tggaacagat tttactttca ccatcagcag cctgcaacct      240

gaagatattg caacttatta ttgtctacag tatgatgagt ttccgctcac gttcggtgct      300

gggaccaagc tggaaatcaa a                                                321


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  17

Lys Ala Ser Gln Asp Ile Tyr Pro Tyr Leu Asn 
1               5                   10      


<210>  18
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  18
aaggcgagtc aggacattta tccctattta aac                                    33


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  19

Arg Thr Asn Arg Leu Leu Asp 
1               5           


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  20
cgtacaaata gattgctaga t                                                 21


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  21

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  22
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  22
ctacagtatg atgagtttcc gctcacg                                           27


<210>  23
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Pro Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Thr Asn Arg Leu Leu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  24
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  24
gacatccaga tgacccagtc tccatcttcc ctgtctgcat ctgtaggaga tagagtcact       60

atcacttgca aggcgagtca ggacatttat ccctatttaa actggttcca acaaaaacca      120

gggaaagctc ctaagaccct gatctatcgt acaaatagat tgctagatgg ggtcccatca      180

aggttcagtg gcagtggatc tggaacagat tttactttca ccatcagcag cctgcaacct      240

gaagatattg caacttatta ttgtctacag tatgatgagt ttccgctcac gttcggtgct      300

gggaccaagc tggaaatcaa acggactgtg gctgcaccaa gtgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  25
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Asp Tyr Thr Tyr Asn Asn Gln Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Ser Tyr Phe Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  26
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  26
caggtccagc ttgtgcagtc tgggcctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gactatgctg tgcattgggt gcgccaggcc      120

cccggaaaaa ggcttgagtg gattggagtg atcagcactt acaatgatta cacatacaat      180

aaccaggact tcaagggcag agtcaccatg accagggaca catccgcgag cacagcctac      240

atggagctga gcagactgag atctgaagac acggctgtgt attactgtgc gagaggtaac      300

tcctacttct atgctttgga ctactggggt caaggaacct cagtcaccgt ctcctca         357


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  27

Asp Tyr Ala Val His 
1               5   


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  28

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  29
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  29
gactatgctg tgcat                                                        15


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  30
ggatacacct tcactgacta t                                                 21


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  31

Val Ile Ser Thr Tyr Asn Asp Tyr Thr Tyr Asn Asn Gln Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  32

Ser Thr Tyr Asn Asp Tyr 
1               5       


<210>  33
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  33
gtgatcagca cttacaatga ttacacatac aataaccagg acttcaaggg c                51


<210>  34
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  34
agcacttaca atgattac                                                     18


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  35

Gly Asn Ser Tyr Phe Tyr Ala Leu Asp Tyr 
1               5                   10  


<210>  36
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  36
ggtaactcct acttctatgc tttggactac                                        30


<210>  37
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Asn Asp Tyr Thr Tyr Asn Asn Gln Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Ser Tyr Phe Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  38
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  38
caggtccagc ttgtgcagtc tgggcctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gactatgctg tgcattgggt gcgccaggcc      120

cccggaaaaa ggcttgagtg gattggagtg atcagcactt acaatgatta cacatacaat      180

aaccaggact tcaagggcag agtcaccatg accagggaca catccgcgag cacagcctac      240

atggagctga gcagactgag atctgaagac acggctgtgt attactgtgc gagaggtaac      300

tcctacttct atgctttgga ctactggggt caaggaacct cagtcaccgt ctcctcagcc      360

tccaccaagg gcccatcggt cttccccctg gcaccctcga gcaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg agccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc ggga                                            1344


<210>  39
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  39

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Lys Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  40
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  40
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtga gagtgttgac agctatggca aaagttttat gcactggtac      120

caacagaaac ctggccaggc tcccaggctc ctcatctata gggcatccaa cctggaatct      180

ggcatcccag ccaggttcag tggcagtggg tctgggacag acttcactct caccatcagc      240

agcctagagc ctgaagattt tgcagtttat tactgtcagc agagtaatga ggatccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  41

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Lys Ser Phe Met His 
1               5                   10                  15  


<210>  42
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  42
agggccagtg agagtgttga cagctatggc aaaagtttta tgcac                       45


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  43

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  44
agggcatcca acctggaatc t                                                 21


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  45

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  46
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  46
cagcagagta atgaggatcc gtggacg                                           27


<210>  47
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  47

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Lys Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  48
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  48
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtga gagtgttgac agctatggca aaagttttat gcactggtac      120

caacagaaac ctggccaggc tcccaggctc ctcatctata gggcatccaa cctggaatct      180

ggcatcccag ccaggttcag tggcagtggg tctgggacag acttcactct caccatcagc      240

agcctagagc ctgaagattt tgcagtttat tactgtcagc agagtaatga ggatccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaacggactg tggctgcacc aagtgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  49
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Leu Asn Pro Asp Ser Ser Ala Ile Asn Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Ile Thr Thr Leu Val Pro Tyr Thr Met Asp Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  50
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  50
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cgactttagt agatattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcggcgac ctaaacccag attcaagtgc gataaactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac actcattact      300

acgttagtac cctatactat ggacttctgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  51

Arg Tyr Trp Met Ser 
1               5   


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  52

Gly Phe Asp Phe Ser Arg Tyr 
1               5           


<210>  53
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  53
agatattgga tgagc                                                        15


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  54
ggattcgact ttagtagata t                                                 21


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  55

Asp Leu Asn Pro Asp Ser Ser Ala Ile Asn Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  56

Asn Pro Asp Ser Ser Ala 
1               5       


<210>  57
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  57
gacctaaacc cagattcaag tgcgataaac tatgtggact ctgtgaaggg c                51


<210>  58
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  58
aacccagatt caagtgcg                                                     18


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  59

Ile Thr Thr Leu Val Pro Tyr Thr Met Asp Phe 
1               5                   10      


<210>  60
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  60
attactacgt tagtacccta tactatggac ttc                                    33


<210>  61
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Leu Asn Pro Asp Ser Ser Ala Ile Asn Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Ile Thr Thr Leu Val Pro Tyr Thr Met Asp Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  62
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  62
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cgactttagt agatattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcggcgac ctaaacccag attcaagtgc gataaactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac actcattact      300

acgttagtac cctatactat ggacttctgg ggtcaaggaa cctcagtcac cgtctcctca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cgagcaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgagccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggt                                         1347


<210>  63
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  63

Glu Thr Thr Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly 
1               5                   10                  15      


Asp Lys Val Asn Ile Ser Cys Ile Thr Asn Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Ala Ile Leu Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Gly Leu Arg Pro Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Leu Gln Ser Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  64
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  64
gaaacgacac tcacgcagtc tccagcattc atgtcagcga ctccaggaga caaagtcaac       60

atctcctgca taaccaacac agacattgat gatgatatga actggtacca acagaaacca      120

ggagaagctg ctattctcct tatttcagaa ggtaatggtc tccgtcctgg aatcccacct      180

cgattcagtg gcagcgggta tggaacagat tttaccctca caattaataa catagaatct      240

gaggatgctg catattactt ctgtctacaa agtgataact tgcctctcac gttcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  65

Ile Thr Asn Thr Asp Ile Asp Asp Asp Met Asn 
1               5                   10      


<210>  66
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  66
ataaccaaca cagacattga tgatgatatg aac                                    33


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  67

Glu Gly Asn Gly Leu Arg Pro 
1               5           


<210>  68
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  68
gaaggtaatg gtctccgtcc t                                                 21


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  69

Leu Gln Ser Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  70
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  70
ctacaaagtg ataacttgcc tctcacg                                           27


<210>  71
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  71

Glu Thr Thr Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly 
1               5                   10                  15      


Asp Lys Val Asn Ile Ser Cys Ile Thr Asn Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Ala Ile Leu Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Gly Leu Arg Pro Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Leu Gln Ser Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  72
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  72
gaaacgacac tcacgcagtc tccagcattc atgtcagcga ctccaggaga caaagtcaac       60

atctcctgca taaccaacac agacattgat gatgatatga actggtacca acagaaacca      120

ggagaagctg ctattctcct tatttcagaa ggtaatggtc tccgtcctgg aatcccacct      180

cgattcagtg gcagcgggta tggaacagat tttaccctca caattaataa catagaatct      240

gaggatgctg catattactt ctgtctacaa agtgataact tgcctctcac gttcggctcg      300

gggacaaagt tggaaataaa acggactgtg gctgcaccaa gtgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  73
<211>  1070
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Gly Ala Ala Arg Gly Ser Pro Ala Arg Pro Arg Arg Leu Pro Leu 
1               5                   10                  15      


Leu Ser Val Leu Leu Leu Pro Leu Leu Gly Gly Thr Gln Thr Ala Ile 
            20                  25                  30          


Val Phe Ile Lys Gln Pro Ser Ser Gln Asp Ala Leu Gln Gly Arg Arg 
        35                  40                  45              


Ala Leu Leu Arg Cys Glu Val Glu Ala Pro Gly Pro Val His Val Tyr 
    50                  55                  60                  


Trp Leu Leu Asp Gly Ala Pro Val Gln Asp Thr Glu Arg Arg Phe Ala 
65                  70                  75                  80  


Gln Gly Ser Ser Leu Ser Phe Ala Ala Val Asp Arg Pro Gln Asp Ser 
                85                  90                  95      


Gly Thr Phe Gln Cys Val Ala Arg Asp Asp Val Thr Gly Glu Glu Ala 
            100                 105                 110         


Arg Ser Ala Asn Ala Ser Phe Asn Ile Lys Trp Ile Glu Ala Gly Pro 
        115                 120                 125             


Val Val Leu Lys His Pro Ala Ser Glu Ala Glu Ile Gln Pro Gln Thr 
    130                 135                 140                 


Gln Val Thr Leu Arg Cys His Ile Asp Gly His Pro Arg Pro Thr Tyr 
145                 150                 155                 160 


Gln Trp Phe Arg Asp Gly Thr Pro Leu Ser Asp Gly Gln Ser Asn His 
                165                 170                 175     


Thr Val Ser Ser Lys Glu Arg Asn Leu Thr Leu Arg Pro Ala Gly Pro 
            180                 185                 190         


Glu His Ser Gly Leu Tyr Ser Cys Cys Ala His Ser Ala Phe Gly Gln 
        195                 200                 205             


Ala Cys Ser Ser Gln Asn Phe Thr Leu Ser Ile Ala Asp Glu Ser Phe 
    210                 215                 220                 


Ala Arg Val Val Leu Ala Pro Gln Asp Val Val Val Ala Arg Tyr Glu 
225                 230                 235                 240 


Glu Ala Met Phe His Cys Gln Phe Ser Ala Gln Pro Pro Pro Ser Leu 
                245                 250                 255     


Gln Trp Leu Phe Glu Asp Glu Thr Pro Ile Thr Asn Arg Ser Arg Pro 
            260                 265                 270         


Pro His Leu Arg Arg Ala Thr Val Phe Ala Asn Gly Ser Leu Leu Leu 
        275                 280                 285             


Thr Gln Val Arg Pro Arg Asn Ala Gly Ile Tyr Arg Cys Ile Gly Gln 
    290                 295                 300                 


Gly Gln Arg Gly Pro Pro Ile Ile Leu Glu Ala Thr Leu His Leu Ala 
305                 310                 315                 320 


Glu Ile Glu Asp Met Pro Leu Phe Glu Pro Arg Val Phe Thr Ala Gly 
                325                 330                 335     


Ser Glu Glu Arg Val Thr Cys Leu Pro Pro Lys Gly Leu Pro Glu Pro 
            340                 345                 350         


Ser Val Trp Trp Glu His Ala Gly Val Arg Leu Pro Thr His Gly Arg 
        355                 360                 365             


Val Tyr Gln Lys Gly His Glu Leu Val Leu Ala Asn Ile Ala Glu Ser 
    370                 375                 380                 


Asp Ala Gly Val Tyr Thr Cys His Ala Ala Asn Leu Ala Gly Gln Arg 
385                 390                 395                 400 


Arg Gln Asp Val Asn Ile Thr Val Ala Thr Val Pro Ser Trp Leu Lys 
                405                 410                 415     


Lys Pro Gln Asp Ser Gln Leu Glu Glu Gly Lys Pro Gly Tyr Leu Asp 
            420                 425                 430         


Cys Leu Thr Gln Ala Thr Pro Lys Pro Thr Val Val Trp Tyr Arg Asn 
        435                 440                 445             


Gln Met Leu Ile Ser Glu Asp Ser Arg Phe Glu Val Phe Lys Asn Gly 
    450                 455                 460                 


Thr Leu Arg Ile Asn Ser Val Glu Val Tyr Asp Gly Thr Trp Tyr Arg 
465                 470                 475                 480 


Cys Met Ser Ser Thr Pro Ala Gly Ser Ile Glu Ala Gln Ala Arg Val 
                485                 490                 495     


Gln Val Leu Glu Lys Leu Lys Phe Thr Pro Pro Pro Gln Pro Gln Gln 
            500                 505                 510         


Cys Met Glu Phe Asp Lys Glu Ala Thr Val Pro Cys Ser Ala Thr Gly 
        515                 520                 525             


Arg Glu Lys Pro Thr Ile Lys Trp Glu Arg Ala Asp Gly Ser Ser Leu 
    530                 535                 540                 


Pro Glu Trp Val Thr Asp Asn Ala Gly Thr Leu His Phe Ala Arg Val 
545                 550                 555                 560 


Thr Arg Asp Asp Ala Gly Asn Tyr Thr Cys Ile Ala Ser Asn Gly Pro 
                565                 570                 575     


Gln Gly Gln Ile Arg Ala His Val Gln Leu Thr Val Ala Val Phe Ile 
            580                 585                 590         


Thr Phe Lys Val Glu Pro Glu Arg Thr Thr Val Tyr Gln Gly His Thr 
        595                 600                 605             


Ala Leu Leu Gln Cys Glu Ala Gln Gly Asp Pro Lys Pro Leu Ile Gln 
    610                 615                 620                 


Trp Lys Gly Lys Asp Arg Ile Leu Asp Pro Thr Lys Leu Gly Pro Arg 
625                 630                 635                 640 


Met His Ile Phe Gln Asn Gly Ser Leu Val Ile His Asp Val Ala Pro 
                645                 650                 655     


Glu Asp Ser Gly Arg Tyr Thr Cys Ile Ala Gly Asn Ser Cys Asn Ile 
            660                 665                 670         


Lys His Thr Glu Ala Pro Leu Tyr Val Val Asp Lys Pro Val Pro Glu 
        675                 680                 685             


Glu Ser Glu Gly Pro Gly Ser Pro Pro Pro Tyr Lys Met Ile Gln Thr 
    690                 695                 700                 


Ile Gly Leu Ser Val Gly Ala Ala Val Ala Tyr Ile Ile Ala Val Leu 
705                 710                 715                 720 


Gly Leu Met Phe Tyr Cys Lys Lys Arg Cys Lys Ala Lys Arg Leu Gln 
                725                 730                 735     


Lys Gln Pro Glu Gly Glu Glu Pro Glu Met Glu Cys Leu Asn Gly Gly 
            740                 745                 750         


Pro Leu Gln Asn Gly Gln Pro Ser Ala Glu Ile Gln Glu Glu Val Ala 
        755                 760                 765             


Leu Thr Ser Leu Gly Ser Gly Pro Ala Ala Thr Asn Lys Arg His Ser 
    770                 775                 780                 


Thr Ser Asp Lys Met His Phe Pro Arg Ser Ser Leu Gln Pro Ile Thr 
785                 790                 795                 800 


Thr Leu Gly Lys Ser Glu Phe Gly Glu Val Phe Leu Ala Lys Ala Gln 
                805                 810                 815     


Gly Leu Glu Glu Gly Val Ala Glu Thr Leu Val Leu Val Lys Ser Leu 
            820                 825                 830         


Gln Ser Lys Asp Glu Gln Gln Gln Leu Asp Phe Arg Arg Glu Leu Glu 
        835                 840                 845             


Met Phe Gly Lys Leu Asn His Ala Asn Val Val Arg Leu Leu Gly Leu 
    850                 855                 860                 


Cys Arg Glu Ala Glu Pro His Tyr Met Val Leu Glu Tyr Val Asp Leu 
865                 870                 875                 880 


Gly Asp Leu Lys Gln Phe Leu Arg Ile Ser Lys Ser Lys Asp Glu Lys 
                885                 890                 895     


Leu Lys Ser Gln Pro Leu Ser Thr Lys Gln Lys Val Ala Leu Cys Thr 
            900                 905                 910         


Gln Val Ala Leu Gly Met Glu His Leu Ser Asn Asn Arg Phe Val His 
        915                 920                 925             


Lys Asp Leu Ala Ala Arg Asn Cys Leu Val Ser Ala Gln Arg Gln Val 
    930                 935                 940                 


Lys Val Ser Ala Leu Gly Leu Ser Lys Asp Val Tyr Asn Ser Glu Tyr 
945                 950                 955                 960 


Tyr His Phe Arg Gln Ala Trp Val Pro Leu Arg Trp Met Ser Pro Glu 
                965                 970                 975     


Ala Ile Leu Glu Gly Asp Phe Ser Thr Lys Ser Asp Val Trp Ala Phe 
            980                 985                 990         


Gly Val Leu Met Trp Glu Val Phe  Thr His Gly Glu Met  Pro His Gly 
        995                 1000                 1005             


Gly Gln  Ala Asp Asp Glu Val  Leu Ala Asp Leu Gln  Ala Gly Lys 
    1010                 1015                 1020             


Ala Arg  Leu Pro Gln Pro Glu  Gly Cys Pro Ser Lys  Leu Tyr Arg 
    1025                 1030                 1035             


Leu Met  Gln Arg Cys Trp Ala  Leu Ser Pro Lys Asp  Arg Pro Ser 
    1040                 1045                 1050             


Phe Ser  Glu Ile Ala Ser Ala  Leu Gly Asp Ser Thr  Val Asp Ser 
    1055                 1060                 1065             


Lys Pro  
    1070 


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  74

Gly Gly Leu Leu Gln Gly Gly 
1               5           


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  75

Leu Leu Gln Gly Ala 
1               5   


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  76

Gly Gly Leu Leu Gln Gly Ala 
1               5           


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  77

Leu Leu Gln Gly Pro Gly Lys 
1               5           


<210>  78
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  78

Leu Leu Gln Gly Pro Gly 
1               5       


<210>  79
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  79

Leu Leu Gln Gly Pro Ala 
1               5       


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  80

Leu Leu Gln Gly Pro 
1               5   


<210>  81
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  81

Leu Leu Gln Pro 
1               


<210>  82
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  82

Leu Leu Gln Pro Gly Lys 
1               5       


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  83

Leu Leu Gln Gly Ala Pro Gly Lys 
1               5               


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  84

Leu Leu Gln Gly Ala Pro Gly 
1               5           


<210>  85
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  85

Leu Leu Gln Gly Ala Pro 
1               5       


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be G or P

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be A, G, P, or absent

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be A, G, K, P, or absent

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be G, K, or absent

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be K or absent

<400>  86

Leu Leu Gln Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid or absent

<400>  87

Leu Leu Gln Xaa Xaa Xaa Xaa Xaa 
1               5               


