                         SEQUENCE LISTING

<110>  biOasis Technologies, Inc.
        
<120>  P97-POLYNUCLEOTIDE CONJUGATES

<130>  BIOA-010/03WO

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Gly Pro Ser Gly Ala Leu Trp Leu Leu Leu Ala Leu Arg Thr 
1               5                   10                  15      


Val Leu Gly Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu 
            20                  25                  30          


Gln His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile 
        35                  40                  45              


Gln Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val 
    50                  55                  60                  


Gln Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly 
65                  70                  75                  80  


Ala Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly 
                85                  90                  95      


Glu Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val 
            100                 105                 110         


Val Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys 
        115                 120                 125             


Ser Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val 
    130                 135                 140                 


Gly Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val 
145                 150                 155                 160 


Leu Lys Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala 
                165                 170                 175     


Gly Glu Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp 
            180                 185                 190         


Ser Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr 
        195                 200                 205             


Asp Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val 
    210                 215                 220                 


Ala Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr 
225                 230                 235                 240 


Leu Pro Ser Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu 
                245                 250                 255     


Cys Arg Asp Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His 
            260                 265                 270         


Leu Ala Arg Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp 
        275                 280                 285             


Gly Gly Leu Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser 
    290                 295                 300                 


His Glu Gly Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln 
305                 310                 315                 320 


Lys Asp Leu Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala 
                325                 330                 335     


Thr Gln Thr Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met 
            340                 345                 350         


Lys Gly Leu Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp 
        355                 360                 365             


Cys Val Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val 
    370                 375                 380                 


Ala Phe Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala 
385                 390                 395                 400 


Lys Ser Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp 
                405                 410                 415     


Ala Val Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr 
            420                 425                 430         


Gly Leu Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser 
        435                 440                 445             


Asn Ser Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala 
    450                 455                 460                 


Phe Thr Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe 
465                 470                 475                 480 


Gly Ser Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg 
                485                 490                 495     


Gly Phe Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu 
            500                 505                 510         


Phe Phe Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro 
        515                 520                 525             


Ser Ser Leu Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys 
    530                 535                 540                 


Cys Val Gly Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe 
545                 550                 555                 560 


Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr 
                565                 570                 575     


Thr Val Phe Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala 
            580                 585                 590         


Glu Leu Arg Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg 
        595                 600                 605             


Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro 
    610                 615                 620                 


His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly 
625                 630                 635                 640 


Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn 
                645                 650                 655     


Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu 
            660                 665                 670         


Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr 
        675                 680                 685             


Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met 
    690                 695                 700                 


Ser Ser Gln Gln Cys Ser Gly Ala Ala Ala Pro Ala Pro Gly Ala Pro 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Leu Pro Ala Leu Ala Ala Arg Leu Leu Pro Pro 
                725                 730                 735     


Ala Leu 
        


<210>  2
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys 
625                 630                 635                 640 


Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp 
                645                 650                 655     


Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly 
            660                 665                 670         


Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln 
        675                 680                 685             


Gln Cys Ser Gly 
    690         


<210>  3
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  3

Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys 
1               5                   10      


<210>  5
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys 
1               5                   10              


<210>  6
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  6

Leu Cys Arg Gly Asp Ser Ser Gly Glu Gly Val Cys Asp Lys 
1               5                   10                  


<210>  7
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Asp Ser Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg 
1               5                   10                  15      


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Tyr Tyr Asp Tyr Ser Gly Ala Phe Arg 
1               5                   


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Asp Val Thr Glu Trp Arg 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Pro Ala His Ala Val Val Val Arg 
1               5                   


<210>  11
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Asp Thr Asp Gly Gly Leu Ile Phe Arg 
1               5                   10  


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Gly Asp Met Ala Val Ala Phe Arg 
1               5                   


<210>  13
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys 
1               5                   10      


<210>  14
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg 
1               5                   10          


<210>  15
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg 
1               5                   10              


<210>  16
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys 
1               5                   10                  15  


<210>  17
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  17

Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu Leu Phe Lys Asp Ser 
1               5                   10                  15      


Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr Tyr Glu Ala Trp Leu 
            20                  25                  30          


Gly His Glu Tyr Leu His Ala Met 
        35                  40  


<210>  18
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr Leu Ser Gly Glu 
1               5                   10                  15      


Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val Pro Ala Ala Gly 
            20                  25                  30          


Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr Tyr Val Val Ala 
        35                  40                  45              


Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg 
    50                  55                  60                  


Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro Ala Gly Trp Asp 
65                  70                  75                  80  


Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile Arg Pro Lys Asp 
                85                  90                  95      


Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn Ala Ser Cys Val 
            100                 105                 110         


Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu Cys Ala Leu Cys 
        115                 120                 125             


Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly Asn Ser Gln Glu 
    130                 135                 140                 


Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu Val Glu Asn Ala 
145                 150                 155                 160 


Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe Asp Asn Thr Asn 
                165                 170                 175     


Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg Ser Glu Asp Tyr 
            180                 185                 190         


Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val Ser Gln Phe Ala 
        195                 200                 205             


Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val Met 
    210                 215                 220     


<210>  19
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  19

Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp Lys 
1               5                   10                  15      


Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys Met 
            20                  25                  30          


<210>  20
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn 
                


<210>  21
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg Ser Glu Asp Tyr 
1               5                   10                  15      


Glu Leu Leu Cys Pro Asn 
            20          


<210>  22
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Ala Arg Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln 
1               5                   10                  15      


Ile Pro Pro His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr 
            20                  25                  30          


Val Tyr Gly Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His 
        35                  40                  45              


Asn Lys Asn 
    50      


<210>  23
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu 
1               5                   10                  15      


Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr 
            20                  25                  30          


Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met 
        35                  40                  45              


Ser Ser Gln Gln Cys 
    50              


<210>  24
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  24

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn 
            580                 585     


<210>  25
<211>  637
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn 
625                 630                 635         


<210>  26
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg Ser Glu Asp Tyr 
1               5                   10                  15      


Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val Ser Gln Phe Ala 
            20                  25                  30          


Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val Met Val Arg Pro 
        35                  40                  45              


Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp Lys Ala Gln Asp 
    50                  55                  60                  


Leu Phe Gly Asp Asp His Asn Lys Asn 
65                  70              


<210>  27
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg Ser Glu Asp Tyr 
1               5                   10                  15      


Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val Ser Gln Phe Ala 
            20                  25                  30          


Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val Met Val Arg Pro 
        35                  40                  45              


Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp Lys Ala Gln Asp 
    50                  55                  60                  


Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys Met Phe Asp Ser 
65                  70                  75                  80  


Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp Ala Thr Val Arg 
                85                  90                  95      


Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly Trp Leu Gly Leu 
            100                 105                 110         


Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln Gln Cys 
        115                 120                 125     


<210>  28
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Ala Arg Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln 
1               5                   10                  15      


Ile Pro Pro His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr 
            20                  25                  30          


Val Tyr Gly Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His 
        35                  40                  45              


Asn Lys Asn Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln 
    50                  55                  60                  


Asp Leu Leu Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu 
65                  70                  75                  80  


Lys Thr Thr Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu 
                85                  90                  95      


Glu Gly Met Ser Ser Gln Gln Cys 
            100                 


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified p97 protein fragment

<400>  29

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Tyr Cys 
1               5                   10                  


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified p97 protein fragment

<400>  30

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Cys 
1               5                   10              


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense NOX4 polynucleotide (siRNA)

<400>  31
auguucacaa agucagguct t                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense NOX4 polynucleotide (siRNA)

<400>  32
gaccugacuu ugugaacaut t                                                 21


<210>  33
<211>  12
<212>  PRT
<213>  Jaculus jaculus

<400>  33

Asp Ser Ser Asp Ala Phe Thr Leu Asp Glu Leu Arg 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  Otolemur garnettii

<400>  34

Asp Ser Ser His Ser Phe Thr Leu Asp Glu Leu Arg 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Ictidomys tridecemlineatus

<400>  35

Asp Ser Ser Tyr Ala Phe Thr Leu Asp Glu Leu Arg 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Ceratotherium simum simum

<400>  36

Asn Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Vicugna pacos

<400>  37

Asn Ser Ser Tyr Ala Phe Thr Leu Asp Glu Leu Arg 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Ochotona princeps

<400>  38

Asp Ser Ser Tyr Ala Phe Pro Leu Asp Glu Leu Arg 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Tupaia chinensis

<400>  39

Asp Ser Thr His Ala Phe Thr Val Asp Glu Leu Arg 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  40

Asp Ser Ser Tyr Ser Phe Thr Leu Asp Glu Leu Arg 
1               5                   10          


<210>  41
<211>  12
<212>  PRT
<213>  Orcinus orca

<400>  41

Asn Ser Ser Asn Ala Phe Thr Leu Asp Glu Leu Arg 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  Chinchilla lanigera

<400>  42

Asp Ser Ser Ser Ala Phe Thr Leu Asn Glu Leu Arg 
1               5                   10          


<210>  43
<211>  12
<212>  PRT
<213>  Dasypus novemcinctus

<400>  43

Asp Ser Ser Tyr Ala Phe Thr Leu Asp Glu Leu Trp 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Odobenus rosmarus divergens

<400>  44

Asn Ser Ser Ser Ala Phe Thr Leu Asp Glu Leu Arg 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Cyphellophora europaea

<400>  45

Ala Thr Ser His Ala Ile Thr Leu Asp Glu Leu Arg 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Loxodonta africana

<400>  46

Asn Ser Ser Tyr Ala Phe Thr Met Asp Glu Leu Arg 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Cricetulus griseus

<400>  47

Asp Arg Ser Tyr Ser Phe Thr Leu Asp Glu Leu Arg 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  48

Asp Ser Ala Tyr Ala Phe Thr Val Asp Glu Leu Arg 
1               5                   10          


<210>  49
<211>  12
<212>  PRT
<213>  Octodon degus

<400>  49

Asp Ser Ser Ser Ala Phe Asn Leu Asn Glu Leu Arg 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Canis lupus familiaris

<400>  50

Asn Ser Ser Asp Ala Phe Ser Leu Asp Glu Leu Arg 
1               5                   10          


<210>  51
<211>  12
<212>  PRT
<213>  Monodelphis domestica

<400>  51

Asn Ser Ser Tyr Ser Phe Thr Leu Asp Glu Leu Arg 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Equus caballus

<400>  52

Asn Ser Ser Tyr Ala Phe Thr Val Asp Glu Leu Arg 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  Condylura cristata

<400>  53

Asn Ser Ser Tyr Ala Phe Ser Leu Asp Glu Leu Arg 
1               5                   10          


<210>  54
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  54

Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys 
1               5                   10      


<210>  55
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  55

Ser Asp Thr Ser Leu Thr Trp Asn Ser Val Lys 
1               5                   10      


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  56
aactttggca ttgtggaagg                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  57
acacattggg ggtaggaaca                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  58
gcctttattg tgcggagaga                                                   20


<210>  59
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  59
cttgacttga tggaggcagt ag                                                22


