                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Compositions And Methods For Identification, Assessment, 
       Prevention, And Treatment Of Cancer Using NFS1 Biomarkers And 
       Modulators

<130>  DFS-136.25

<140>  PCT/US2015/29439
<141>  2015-05-06

<150>  61/989,037
<151>  2014-05-06

<160>  111   

<170>  PatentIn version 3.5

<210>  1
<211>  1374
<212>  DNA
<213>  Homo sapiens

<400>  1
atgctgctcc gagccgcttg gaggcgggcg gcagtggcgg tgacagcggc tccagggccg       60

aagcccgcgg cgcccactcg ggggctgcgc ctgcgcgttg gagaccgtgc tcctcagtct      120

gcggttcccg cagatacagc cgctgccccg gaggtggggc cagtgctgcg acctctctat      180

atggatgtgc aagctacaac tcctctggac ccccgggtgc ttgatgccat gctcccttac      240

ctaatcaact actatgggaa cccacactcc cggacacatg cttatggctg ggagagtgag      300

gcagccatgg aacgtgctcg tcagcaagta gcatctctga ttggagctga tcctcgtgag      360

atcattttta ctagtggtgc tactgaatcc aacaacatag caattaaggg ggtggcccga      420

ttctacaggt cacggaaaaa gcacttgatc accacccaga cagaacacaa atgtgtcttg      480

gactcctgcc gttcactgga agctgagggc tttcaggtca cctacctccc agtgcagaag      540

agtgggatca ttgacctaaa ggaactagag gctgctatcc agccagatac tagcctggtg      600

tcagtcatga ctgtgaacaa tgagattgga gtgaagcagc ctattgcaga aatagggcgg      660

atttgcagtt ccagaaaggt atatttccat actgatgcag cccaggctgt tggaaaaatc      720

ccacttgatg tcaatgacat gaaaattgat ctcatgagca ttagtggtca caaaatctac      780

ggtcccaaag gggttggtgc catctacatc cgtcgccggc cccgtgtgcg tgtggaggcc      840

ctgcagagtg gaggggggca ggagcggggt atgcggtctg ggacagtgcc cacaccctta      900

gtggtggggc tgggggctgc gtgtgaggtg gcacagcaag agatggagta tgaccacaag      960

cgaatctcaa agttgtcaga gcggctgata cagaatataa tgaagagcct tccagatgtg     1020

gtgatgaatg gggaccctaa gcaccattat cccggctgta tcaacctctc ctttgcatat     1080

gtggaagggg aaagtctgct gatggcactg aaggacgttg ccttatcctc agggagtgcc     1140

tgcacctctg catccctgga gccctcttat gtgcttagag caattggcac tgatgaggat     1200

ttagcgcact cttctatcag gtttggaatt ggccgcttca ctacagagga ggaagtggac     1260

tacacagtgg agaaatgcat tcagcatgtg aagcgtcttc gagaaatgag ccctctctgg     1320

gagatggttc aggatggcat tgacctcaag agcatcaagt ggacccaaca ctag           1374


<210>  2
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Leu Arg Ala Ala Trp Arg Arg Ala Ala Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Pro Gly Pro Lys Pro Ala Ala Pro Thr Arg Gly Leu Arg Leu Arg 
            20                  25                  30          


Val Gly Asp Arg Ala Pro Gln Ser Ala Val Pro Ala Asp Thr Ala Ala 
        35                  40                  45              


Ala Pro Glu Val Gly Pro Val Leu Arg Pro Leu Tyr Met Asp Val Gln 
    50                  55                  60                  


Ala Thr Thr Pro Leu Asp Pro Arg Val Leu Asp Ala Met Leu Pro Tyr 
65                  70                  75                  80  


Leu Ile Asn Tyr Tyr Gly Asn Pro His Ser Arg Thr His Ala Tyr Gly 
                85                  90                  95      


Trp Glu Ser Glu Ala Ala Met Glu Arg Ala Arg Gln Gln Val Ala Ser 
            100                 105                 110         


Leu Ile Gly Ala Asp Pro Arg Glu Ile Ile Phe Thr Ser Gly Ala Thr 
        115                 120                 125             


Glu Ser Asn Asn Ile Ala Ile Lys Gly Val Ala Arg Phe Tyr Arg Ser 
    130                 135                 140                 


Arg Lys Lys His Leu Ile Thr Thr Gln Thr Glu His Lys Cys Val Leu 
145                 150                 155                 160 


Asp Ser Cys Arg Ser Leu Glu Ala Glu Gly Phe Gln Val Thr Tyr Leu 
                165                 170                 175     


Pro Val Gln Lys Ser Gly Ile Ile Asp Leu Lys Glu Leu Glu Ala Ala 
            180                 185                 190         


Ile Gln Pro Asp Thr Ser Leu Val Ser Val Met Thr Val Asn Asn Glu 
        195                 200                 205             


Ile Gly Val Lys Gln Pro Ile Ala Glu Ile Gly Arg Ile Cys Ser Ser 
    210                 215                 220                 


Arg Lys Val Tyr Phe His Thr Asp Ala Ala Gln Ala Val Gly Lys Ile 
225                 230                 235                 240 


Pro Leu Asp Val Asn Asp Met Lys Ile Asp Leu Met Ser Ile Ser Gly 
                245                 250                 255     


His Lys Ile Tyr Gly Pro Lys Gly Val Gly Ala Ile Tyr Ile Arg Arg 
            260                 265                 270         


Arg Pro Arg Val Arg Val Glu Ala Leu Gln Ser Gly Gly Gly Gln Glu 
        275                 280                 285             


Arg Gly Met Arg Ser Gly Thr Val Pro Thr Pro Leu Val Val Gly Leu 
    290                 295                 300                 


Gly Ala Ala Cys Glu Val Ala Gln Gln Glu Met Glu Tyr Asp His Lys 
305                 310                 315                 320 


Arg Ile Ser Lys Leu Ser Glu Arg Leu Ile Gln Asn Ile Met Lys Ser 
                325                 330                 335     


Leu Pro Asp Val Val Met Asn Gly Asp Pro Lys His His Tyr Pro Gly 
            340                 345                 350         


Cys Ile Asn Leu Ser Phe Ala Tyr Val Glu Gly Glu Ser Leu Leu Met 
        355                 360                 365             


Ala Leu Lys Asp Val Ala Leu Ser Ser Gly Ser Ala Cys Thr Ser Ala 
    370                 375                 380                 


Ser Leu Glu Pro Ser Tyr Val Leu Arg Ala Ile Gly Thr Asp Glu Asp 
385                 390                 395                 400 


Leu Ala His Ser Ser Ile Arg Phe Gly Ile Gly Arg Phe Thr Thr Glu 
                405                 410                 415     


Glu Glu Val Asp Tyr Thr Val Glu Lys Cys Ile Gln His Val Lys Arg 
            420                 425                 430         


Leu Arg Glu Met Ser Pro Leu Trp Glu Met Val Gln Asp Gly Ile Asp 
        435                 440                 445             


Leu Lys Ser Ile Lys Trp Thr Gln His 
    450                 455         


<210>  3
<211>  1221
<212>  DNA
<213>  Homo sapiens

<400>  3
atgctgctcc gagccgcttg gaggcgggcg gcagtggcgg tgacagcggc tccagggccg       60

aagcccgcgg cgcccactcg ggggctgcgc ctgcgcgttg gagaccgtgc tcctcagtct      120

gcggttcccg cagatacagc cgctgccccg gaggtggggc cagtgctgcg acctctctat      180

atggatgtgc aagctacaac tcctctggac ccccgggtgc ttgatgccat gctcccttac      240

ctaatcaact actatgggaa cccacactcc cggacacatg cttatggctg ggagagtgag      300

gcagccatgg aacgtgctcg tcagcaagta gcatctctga ttggagctga tcctcgtgag      360

atcattttta ctagtggtgc tactgaatcc aacaacatag caattaagga actagaggct      420

gctatccagc cagatactag cctggtgtca gtcatgactg tgaacaatga gattggagtg      480

aagcagccta ttgcagaaat agggcggatt tgcagttcca gaaaggtata tttccatact      540

gatgcagccc aggctgttgg aaaaatccca cttgatgtca atgacatgaa aattgatctc      600

atgagcatta gtggtcacaa aatctacggt cccaaagggg ttggtgccat ctacatccgt      660

cgccggcccc gtgtgcgtgt ggaggccctg cagagtggag gggggcagga gcggggtatg      720

cggtctggga cagtgcccac acccttagtg gtggggctgg gggctgcgtg tgaggtggca      780

cagcaagaga tggagtatga ccacaagcga atctcaaagt tgtcagagcg gctgatacag      840

aatataatga agagccttcc agatgtggtg atgaatgggg accctaagca ccattatccc      900

ggctgtatca acctctcctt tgcatatgtg gaaggggaaa gtctgctgat ggcactgaag      960

gacgttgcct tatcctcagg gagtgcctgc acctctgcat ccctggagcc ctcttatgtg     1020

cttagagcaa ttggcactga tgaggattta gcgcactctt ctatcaggtt tggaattggc     1080

cgcttcacta cagaggagga agtggactac acagtggaga aatgcattca gcatgtgaag     1140

cgtcttcgag aaatgagccc tctctgggag atggttcagg atggcattga cctcaagagc     1200

atcaagtgga cccaacacta g                                               1221


<210>  4
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Leu Arg Ala Ala Trp Arg Arg Ala Ala Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Pro Gly Pro Lys Pro Ala Ala Pro Thr Arg Gly Leu Arg Leu Arg 
            20                  25                  30          


Val Gly Asp Arg Ala Pro Gln Ser Ala Val Pro Ala Asp Thr Ala Ala 
        35                  40                  45              


Ala Pro Glu Val Gly Pro Val Leu Arg Pro Leu Tyr Met Asp Val Gln 
    50                  55                  60                  


Ala Thr Thr Pro Leu Asp Pro Arg Val Leu Asp Ala Met Leu Pro Tyr 
65                  70                  75                  80  


Leu Ile Asn Tyr Tyr Gly Asn Pro His Ser Arg Thr His Ala Tyr Gly 
                85                  90                  95      


Trp Glu Ser Glu Ala Ala Met Glu Arg Ala Arg Gln Gln Val Ala Ser 
            100                 105                 110         


Leu Ile Gly Ala Asp Pro Arg Glu Ile Ile Phe Thr Ser Gly Ala Thr 
        115                 120                 125             


Glu Ser Asn Asn Ile Ala Ile Lys Glu Leu Glu Ala Ala Ile Gln Pro 
    130                 135                 140                 


Asp Thr Ser Leu Val Ser Val Met Thr Val Asn Asn Glu Ile Gly Val 
145                 150                 155                 160 


Lys Gln Pro Ile Ala Glu Ile Gly Arg Ile Cys Ser Ser Arg Lys Val 
                165                 170                 175     


Tyr Phe His Thr Asp Ala Ala Gln Ala Val Gly Lys Ile Pro Leu Asp 
            180                 185                 190         


Val Asn Asp Met Lys Ile Asp Leu Met Ser Ile Ser Gly His Lys Ile 
        195                 200                 205             


Tyr Gly Pro Lys Gly Val Gly Ala Ile Tyr Ile Arg Arg Arg Pro Arg 
    210                 215                 220                 


Val Arg Val Glu Ala Leu Gln Ser Gly Gly Gly Gln Glu Arg Gly Met 
225                 230                 235                 240 


Arg Ser Gly Thr Val Pro Thr Pro Leu Val Val Gly Leu Gly Ala Ala 
                245                 250                 255     


Cys Glu Val Ala Gln Gln Glu Met Glu Tyr Asp His Lys Arg Ile Ser 
            260                 265                 270         


Lys Leu Ser Glu Arg Leu Ile Gln Asn Ile Met Lys Ser Leu Pro Asp 
        275                 280                 285             


Val Val Met Asn Gly Asp Pro Lys His His Tyr Pro Gly Cys Ile Asn 
    290                 295                 300                 


Leu Ser Phe Ala Tyr Val Glu Gly Glu Ser Leu Leu Met Ala Leu Lys 
305                 310                 315                 320 


Asp Val Ala Leu Ser Ser Gly Ser Ala Cys Thr Ser Ala Ser Leu Glu 
                325                 330                 335     


Pro Ser Tyr Val Leu Arg Ala Ile Gly Thr Asp Glu Asp Leu Ala His 
            340                 345                 350         


Ser Ser Ile Arg Phe Gly Ile Gly Arg Phe Thr Thr Glu Glu Glu Val 
        355                 360                 365             


Asp Tyr Thr Val Glu Lys Cys Ile Gln His Val Lys Arg Leu Arg Glu 
    370                 375                 380                 


Met Ser Pro Leu Trp Glu Met Val Gln Asp Gly Ile Asp Leu Lys Ser 
385                 390                 395                 400 


Ile Lys Trp Thr Gln His 
                405     


<210>  5
<211>  276
<212>  DNA
<213>  Homo sapiens

<400>  5
atggcagcct ccagtcgcgc acaagtgtta tctctgtacc gggcgatgct gagagagagc       60

aagcgtttca gcgcctacaa ttacagaaca tatgctgtca ggaggataag agatgccttc      120

agagaaaata aaaatgtaaa ggatcctgta gaaattcaaa ccctagtgaa taaagccaag      180

agagaccttg gagtaattcg tcgacaggtc cacattggcc aactgtattc aactgacaag      240

ctgatcattg agaatcgaga catgcccagg acctag                                276


<210>  6
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Ser Ser Arg Ala Gln Val Leu Ser Leu Tyr Arg Ala Met 
1               5                   10                  15      


Leu Arg Glu Ser Lys Arg Phe Ser Ala Tyr Asn Tyr Arg Thr Tyr Ala 
            20                  25                  30          


Val Arg Arg Ile Arg Asp Ala Phe Arg Glu Asn Lys Asn Val Lys Asp 
        35                  40                  45              


Pro Val Glu Ile Gln Thr Leu Val Asn Lys Ala Lys Arg Asp Leu Gly 
    50                  55                  60                  


Val Ile Arg Arg Gln Val His Ile Gly Gln Leu Tyr Ser Thr Asp Lys 
65                  70                  75                  80  


Leu Ile Ile Glu Asn Arg Asp Met Pro Arg Thr 
                85                  90      


<210>  7
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  7
atggcagcct ccagtcgcgc acaagtgtta tctctgtacc gggcgatgct gagagagagc       60

aagcgtttca gcgcctacaa ttacagaaca tatgctgtca ggaggataag agatgccttc      120

agagaaaata aaaatgtaaa ggatcctgta gaaattcaaa ccctagtgaa taaagccaag      180

agagaccttg gagtaattcg tcgacagatg gactctcact ctgtcgccca ggctggagtg      240

cattggaacg atctcagctc actacaacct ctgcctccct ggttcaagca attctcctgc      300

ctcagcctcc cgagtagctg ggattatagg cgcacgccac cacgcctggc taatttttgt      360

attcttagta gagatgtgat ttcactgtat tag                                   393


<210>  8
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ala Ser Ser Arg Ala Gln Val Leu Ser Leu Tyr Arg Ala Met 
1               5                   10                  15      


Leu Arg Glu Ser Lys Arg Phe Ser Ala Tyr Asn Tyr Arg Thr Tyr Ala 
            20                  25                  30          


Val Arg Arg Ile Arg Asp Ala Phe Arg Glu Asn Lys Asn Val Lys Asp 
        35                  40                  45              


Pro Val Glu Ile Gln Thr Leu Val Asn Lys Ala Lys Arg Asp Leu Gly 
    50                  55                  60                  


Val Ile Arg Arg Gln Met Asp Ser His Ser Val Ala Gln Ala Gly Val 
65                  70                  75                  80  


His Trp Asn Asp Leu Ser Ser Leu Gln Pro Leu Pro Pro Trp Phe Lys 
                85                  90                  95      


Gln Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Arg Thr 
            100                 105                 110         


Pro Pro Arg Leu Ala Asn Phe Cys Ile Leu Ser Arg Asp Val Ile Ser 
        115                 120                 125             


Leu Tyr 
    130 


<210>  9
<211>  291
<212>  DNA
<213>  Homo sapiens

<400>  9
atggcagcct ccagtcgcgc acaagtgtta tctctgtacc gggcgatgct gagagagagc       60

aagcgtttca gcgcctacaa ttacagaaca tatgctgtca ggaggataag agatgccttc      120

agagaaaata aaaatgtaaa ggatcctgta gaaattcaaa ccctagtgaa taaagccaag      180

agagaccttg gagtaattcg tcgacaggta gctgagcaag gcacagccgc caggaggaag      240

tcggggaaca gcagccggag cctggggaag ccctgcacaa gttggccttg a               291


<210>  10
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Ala Ser Ser Arg Ala Gln Val Leu Ser Leu Tyr Arg Ala Met 
1               5                   10                  15      


Leu Arg Glu Ser Lys Arg Phe Ser Ala Tyr Asn Tyr Arg Thr Tyr Ala 
            20                  25                  30          


Val Arg Arg Ile Arg Asp Ala Phe Arg Glu Asn Lys Asn Val Lys Asp 
        35                  40                  45              


Pro Val Glu Ile Gln Thr Leu Val Asn Lys Ala Lys Arg Asp Leu Gly 
    50                  55                  60                  


Val Ile Arg Arg Gln Val Ala Glu Gln Gly Thr Ala Ala Arg Arg Lys 
65                  70                  75                  80  


Ser Gly Asn Ser Ser Arg Ser Leu Gly Lys Pro Cys Thr Ser Trp Pro 
                85                  90                  95      


<210>  11
<211>  429
<212>  DNA
<213>  Homo sapiens

<400>  11
atggttctca ttgacatgag tgtagacctt tctactcagg ttgttgatca ttatgaaaat       60

cctagaaacg tggggtccct tgacaagaca tctaaaaatg ttggaactgg actggtgggg      120

gctccagcat gtggtgacgt aatgaaatta cagattcaag tggatgaaaa ggggaagatt      180

gtggatgcta ggtttaaaac atttggctgt ggttccgcaa ttgcctccag ctcattagcc      240

actgaatggg tgaaaggaaa gacggtggag gaagccttga ctatcaaaaa cacagatatc      300

gccaaggagc tctgccttcc tcccgtgaaa ctgcactgct ccatgctggc tgaagatgca      360

atcaaggccg ccctggctga ttacaaattg aaacaagaac ccaaaaaagg agaggcagag      420

aagaaatga                                                              429


<210>  12
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Leu Ile Asp Met Ser Val Asp Leu Ser Thr Gln Val Val Asp 
1               5                   10                  15      


His Tyr Glu Asn Pro Arg Asn Val Gly Ser Leu Asp Lys Thr Ser Lys 
            20                  25                  30          


Asn Val Gly Thr Gly Leu Val Gly Ala Pro Ala Cys Gly Asp Val Met 
        35                  40                  45              


Lys Leu Gln Ile Gln Val Asp Glu Lys Gly Lys Ile Val Asp Ala Arg 
    50                  55                  60                  


Phe Lys Thr Phe Gly Cys Gly Ser Ala Ile Ala Ser Ser Ser Leu Ala 
65                  70                  75                  80  


Thr Glu Trp Val Lys Gly Lys Thr Val Glu Glu Ala Leu Thr Ile Lys 
                85                  90                  95      


Asn Thr Asp Ile Ala Lys Glu Leu Cys Leu Pro Pro Val Lys Leu His 
            100                 105                 110         


Cys Ser Met Leu Ala Glu Asp Ala Ile Lys Ala Ala Leu Ala Asp Tyr 
        115                 120                 125             


Lys Leu Lys Gln Glu Pro Lys Lys Gly Glu Ala Glu Lys Lys 
    130                 135                 140         


<210>  13
<211>  504
<212>  DNA
<213>  Homo sapiens

<400>  13
atggcggcgg ctggggcttt ccgtctgagg cgggcggcat cggctctgct gctgcggagc       60

ccccgcctgc ccgcccggga gctgtcggcc ccggcccgac tctatcacaa gaaggttgtt      120

gatcattatg aaaatcctag aaacgtgggg tcccttgaca agacatctaa aaatgttgga      180

actggactgg tgggggctcc agcatgtggt gacgtaatga aattacagat tcaagtggat      240

gaaaagggga agattgtgga tgctaggttt aaaacatttg gctgtggttc cgcaattgcc      300

tccagctcat tagccactga atgggtgaaa ggaaagacgg tggaggaagc cttgactatc      360

aaaaacacag atatcgccaa ggagctctgc cttcctcccg tgaaactgca ctgctccatg      420

ctggctgaag atgcaatcaa ggccgccctg gctgattaca aattgaaaca agaacccaaa      480

aaaggagagg cagagaagaa atga                                             504


<210>  14
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ala Ala Gly Ala Phe Arg Leu Arg Arg Ala Ala Ser Ala Leu 
1               5                   10                  15      


Leu Leu Arg Ser Pro Arg Leu Pro Ala Arg Glu Leu Ser Ala Pro Ala 
            20                  25                  30          


Arg Leu Tyr His Lys Lys Val Val Asp His Tyr Glu Asn Pro Arg Asn 
        35                  40                  45              


Val Gly Ser Leu Asp Lys Thr Ser Lys Asn Val Gly Thr Gly Leu Val 
    50                  55                  60                  


Gly Ala Pro Ala Cys Gly Asp Val Met Lys Leu Gln Ile Gln Val Asp 
65                  70                  75                  80  


Glu Lys Gly Lys Ile Val Asp Ala Arg Phe Lys Thr Phe Gly Cys Gly 
                85                  90                  95      


Ser Ala Ile Ala Ser Ser Ser Leu Ala Thr Glu Trp Val Lys Gly Lys 
            100                 105                 110         


Thr Val Glu Glu Ala Leu Thr Ile Lys Asn Thr Asp Ile Ala Lys Glu 
        115                 120                 125             


Leu Cys Leu Pro Pro Val Lys Leu His Cys Ser Met Leu Ala Glu Asp 
    130                 135                 140                 


Ala Ile Lys Ala Ala Leu Ala Asp Tyr Lys Leu Lys Gln Glu Pro Lys 
145                 150                 155                 160 


Lys Gly Glu Ala Glu Lys Lys 
                165         


<210>  15
<211>  633
<212>  DNA
<213>  Homo sapiens

<400>  15
atgtggactc tcgggcgccg cgcagtagcc ggcctcctgg cgtcacccag cccagcccag       60

gcccagaccc tcacccgggt cccgcggccg gcagagttgg ccccactctg cggccgccgt      120

ggcctgcgca ccgacatcga tgcgacctgc acgccccgcc gcgcaagttc gaaccaacgt      180

ggcctcaacc agatttggaa tgtcaaaaag cagagtgtct atttgatgaa tttgaggaaa      240

tctggaactt tgggccaccc aggctctcta gatgagacca cctatgaaag actagcagag      300

gaaacgctgg actctttagc agagtttttt gaagaccttg cagacaagcc atacacgttt      360

gaggactatg atgtctcctt tgggagtggt gtcttaactg tcaaactggg tggagatcta      420

ggaacctatg tgatcaacaa gcagacgcca aacaagcaaa tctggctatc ttctccatcc      480

agtggaccta agcgttatga ctggactggg aaaaactggg tgtactccca cgacggcgtg      540

tccctccatg agctgctggc cgcagagctc actaaagcct taaaaaccaa actggacttg      600

tcttccttgg cctattccgg aaaagatgct tga                                   633


<210>  16
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


<210>  17
<211>  591
<212>  DNA
<213>  Homo sapiens

<400>  17
atgtggactc tcgggcgccg cgcagtagcc ggcctcctgg cgtcacccag cccagcccag       60

gcccagaccc tcacccgggt cccgcggccg gcagagttgg ccccactctg cggccgccgt      120

ggcctgcgca ccgacatcga tgcgacctgc acgccccgcc gcgcaagttc gaaccaacgt      180

ggcctcaacc agatttggaa tgtcaaaaag cagagtgtct atttgatgaa tttgaggaaa      240

tctggaactt tgggccaccc aggctctcta gatgagacca cctatgaaag actagcagag      300

gaaacgctgg actctttagc agagtttttt gaagaccttg cagacaagcc atacacgttt      360

gaggactatg atgtctcctt tgggagtggt gtcttaactg tcaaactggg tggagatcta      420

ggaacctatg tgatcaacaa gcagacgcca aacaagcaaa tctggctatc ttctccatcc      480

aggtatgtag tggacctaag cgttatgact ggactgggaa aaactgggtg tactcccacg      540

acggcgtgtc cctccatgag ctgctggccg cagagctcac taaagcctta a               591


<210>  18
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Arg Tyr Val Val Asp Leu Ser Val Met Thr Gly Leu Gly Lys Thr Gly 
                165                 170                 175     


Cys Thr Pro Thr Thr Ala Cys Pro Ser Met Ser Cys Trp Pro Gln Ser 
            180                 185                 190         


Ser Leu Lys Pro 
        195     


<210>  19
<211>  516
<212>  DNA
<213>  Homo sapiens

<400>  19
atgtggactc tcgggcgccg cgcagtagcc ggcctcctgg cgtcacccag cccagcccag       60

gcccagaccc tcacccgggt cccgcggccg gcagagttgg ccccactctg cggccgccgt      120

ggcctgcgca ccgacatcga tgcgacctgc acgccccgcc gcgcaagttc gaaccaacgt      180

ggcctcaacc agatttggaa tgtcaaaaag cagagtgtct atttgatgaa tttgaggaaa      240

tctggaactt tgggccaccc aggctctcta gatgagacca cctatgaaag actagcagag      300

gaaacgctgg actctttagc agagtttttt gaagaccttg cagacaagcc atacacgttt      360

gaggactatg atgtctcctt tgggagtggt gtcttaactg tcaaactggg tggagatcta      420

ggaacctatg tgatcaacaa gcagacgcca aacaagcaaa tctggctatc ttctccatcc      480

aggttaacgt ggctcctgtg gctgttccat ccctga                                516


<210>  20
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Arg Leu Thr Trp Leu Leu Trp Leu Phe His Pro 
                165                 170     


<210>  21
<211>  693
<212>  DNA
<213>  Homo sapiens

<400>  21
atgttgaaga atccatacac cattaagaaa cagcctctgc atcagtttgt acaaagacca       60

cttttcccac tacctgcagc cttttatcac ccagtgagat acatgtttat tcaaacacaa      120

gataccccaa atccaaacag cttaaagttt ataccaggaa aaccagttct tgagacaagg      180

accatggatt ttcccacccc agctgcagca tttcgctccc ctctggctag gcagttattt      240

aggattgaag gagtaaaaag tgtcttcttt ggaccagatt tcatcactgt cacaaaggaa      300

aatgaagaat tagactggaa tttactgaaa ccagatattt atgcaacaat catggacttc      360

tttgcatctg gcttacccct ggttactgag gaaacacctt caggagaagc aggatctgaa      420

gaagatgatg aagttgtggc aatgattaag gaattgttag atactagaat acggccaact      480

gtgcaggaag atggagggga tgtaatctac aaaggctttg aagatggcat tgtacagctg      540

aaactccagg gttcttgtac cagctgccct agttcaatca ttactctgaa aaatggaatt      600

cagaacatgc tgcagtttta tattccggag gtagaaggcg tagaacaggt tatggatgat      660

gaatcagatg aaaaagaagc aaactcacct taa                                   693


<210>  22
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Leu Lys Asn Pro Tyr Thr Ile Lys Lys Gln Pro Leu His Gln Phe 
1               5                   10                  15      


Val Gln Arg Pro Leu Phe Pro Leu Pro Ala Ala Phe Tyr His Pro Val 
            20                  25                  30          


Arg Tyr Met Phe Ile Gln Thr Gln Asp Thr Pro Asn Pro Asn Ser Leu 
        35                  40                  45              


Lys Phe Ile Pro Gly Lys Pro Val Leu Glu Thr Arg Thr Met Asp Phe 
    50                  55                  60                  


Pro Thr Pro Ala Ala Ala Phe Arg Ser Pro Leu Ala Arg Gln Leu Phe 
65                  70                  75                  80  


Arg Ile Glu Gly Val Lys Ser Val Phe Phe Gly Pro Asp Phe Ile Thr 
                85                  90                  95      


Val Thr Lys Glu Asn Glu Glu Leu Asp Trp Asn Leu Leu Lys Pro Asp 
            100                 105                 110         


Ile Tyr Ala Thr Ile Met Asp Phe Phe Ala Ser Gly Leu Pro Leu Val 
        115                 120                 125             


Thr Glu Glu Thr Pro Ser Gly Glu Ala Gly Ser Glu Glu Asp Asp Glu 
    130                 135                 140                 


Val Val Ala Met Ile Lys Glu Leu Leu Asp Thr Arg Ile Arg Pro Thr 
145                 150                 155                 160 


Val Gln Glu Asp Gly Gly Asp Val Ile Tyr Lys Gly Phe Glu Asp Gly 
                165                 170                 175     


Ile Val Gln Leu Lys Leu Gln Gly Ser Cys Thr Ser Cys Pro Ser Ser 
            180                 185                 190         


Ile Ile Thr Leu Lys Asn Gly Ile Gln Asn Met Leu Gln Phe Tyr Ile 
        195                 200                 205             


Pro Glu Val Glu Gly Val Glu Gln Val Met Asp Asp Glu Ser Asp Glu 
    210                 215                 220                 


Lys Glu Ala Asn Ser Pro 
225                 230 


<210>  23
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  23
atggcggcga cggccaggcg gggctgggga gctgcggctg ttgccgccgg gctgcgcagg       60

cggttctgtc atatgttgaa gaatccatac accattaaga aacagcctct gcatcagttt      120

gtacaaagac cacttttccc actacctgca gccttttatc acccagtgag atacatgttt      180

attcaaacac aagatacccc aaatccaaac agcttaaagt ttataccagg aaaaccagtt      240

cttgagacaa ggaccatgga ttttcccacc ccagctgcag catttcgctc ccctctggct      300

aggcagttat ttaggattga aggagtaaaa agtgtcttct ttggaccaga tttcatcact      360

gtcacaaagg aaaatgaaga attagactgg aatttactga aaccagatat ttatgcaaca      420

atcatggact tctttgcatc tggcttaccc ctggttactg aggaaacacc ttcaggagaa      480

gcaggatctg aagaagatga tgaagttgtg gcaatgatta aggaattgtt agatactaga      540

atacggccaa ctgtgcagga agatggaggg gatgtaatct acaaaggctt tgaagatggc      600

attgtacagc tgaaactcca gggttcttgt accagctgcc ctagttcaat cattactctg      660

aaaaatggaa ttcagaacat gctgcagttt tatattccgg aggtagaagg cgtagaacag      720

gttatggatg atgaatcaga tgaaaaagaa gcaaactcac cttaa                      765


<210>  24
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Ala Thr Ala Arg Arg Gly Trp Gly Ala Ala Ala Val Ala Ala 
1               5                   10                  15      


Gly Leu Arg Arg Arg Phe Cys His Met Leu Lys Asn Pro Tyr Thr Ile 
            20                  25                  30          


Lys Lys Gln Pro Leu His Gln Phe Val Gln Arg Pro Leu Phe Pro Leu 
        35                  40                  45              


Pro Ala Ala Phe Tyr His Pro Val Arg Tyr Met Phe Ile Gln Thr Gln 
    50                  55                  60                  


Asp Thr Pro Asn Pro Asn Ser Leu Lys Phe Ile Pro Gly Lys Pro Val 
65                  70                  75                  80  


Leu Glu Thr Arg Thr Met Asp Phe Pro Thr Pro Ala Ala Ala Phe Arg 
                85                  90                  95      


Ser Pro Leu Ala Arg Gln Leu Phe Arg Ile Glu Gly Val Lys Ser Val 
            100                 105                 110         


Phe Phe Gly Pro Asp Phe Ile Thr Val Thr Lys Glu Asn Glu Glu Leu 
        115                 120                 125             


Asp Trp Asn Leu Leu Lys Pro Asp Ile Tyr Ala Thr Ile Met Asp Phe 
    130                 135                 140                 


Phe Ala Ser Gly Leu Pro Leu Val Thr Glu Glu Thr Pro Ser Gly Glu 
145                 150                 155                 160 


Ala Gly Ser Glu Glu Asp Asp Glu Val Val Ala Met Ile Lys Glu Leu 
                165                 170                 175     


Leu Asp Thr Arg Ile Arg Pro Thr Val Gln Glu Asp Gly Gly Asp Val 
            180                 185                 190         


Ile Tyr Lys Gly Phe Glu Asp Gly Ile Val Gln Leu Lys Leu Gln Gly 
        195                 200                 205             


Ser Cys Thr Ser Cys Pro Ser Ser Ile Ile Thr Leu Lys Asn Gly Ile 
    210                 215                 220                 


Gln Asn Met Leu Gln Phe Tyr Ile Pro Glu Val Glu Gly Val Glu Gln 
225                 230                 235                 240 


Val Met Asp Asp Glu Ser Asp Glu Lys Glu Ala Asn Ser Pro 
                245                 250                 


<210>  25
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  25
atggacttct ttgcatctgg cttacccctg gttactgagg aaacaccttc aggagaagca       60

ggatctgaag aagatgatga agttgtggca atgattaagg aattgttaga tactagaata      120

cggccaactg tgcaggaaga tggaggggat gtaatctaca aaggctttga agatggcatt      180

gtacagctga aactccaggg ttcttgtacc agctgcccta gttcaatcat tactctgaaa      240

aatggaattc agaacatgct gcagttttat attccggagg tagaaggcgt agaacaggtt      300

atggatgatg aatcagatga aaaagaagca aactcacctt aa                         342


<210>  26
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Asp Phe Phe Ala Ser Gly Leu Pro Leu Val Thr Glu Glu Thr Pro 
1               5                   10                  15      


Ser Gly Glu Ala Gly Ser Glu Glu Asp Asp Glu Val Val Ala Met Ile 
            20                  25                  30          


Lys Glu Leu Leu Asp Thr Arg Ile Arg Pro Thr Val Gln Glu Asp Gly 
        35                  40                  45              


Gly Asp Val Ile Tyr Lys Gly Phe Glu Asp Gly Ile Val Gln Leu Lys 
    50                  55                  60                  


Leu Gln Gly Ser Cys Thr Ser Cys Pro Ser Ser Ile Ile Thr Leu Lys 
65                  70                  75                  80  


Asn Gly Ile Gln Asn Met Leu Gln Phe Tyr Ile Pro Glu Val Glu Gly 
                85                  90                  95      


Val Glu Gln Val Met Asp Asp Glu Ser Asp Glu Lys Glu Ala Asn Ser 
            100                 105                 110         


Pro 
    


<210>  27
<211>  474
<212>  DNA
<213>  Homo sapiens

<400>  27
atgagcgggt ccctcggccg agctgcggcg gctctgctcc gctgggggcg cggcgcgggc       60

ggcggtggcc tttggggtcc gggcgtgcgg gcggcgggct cgggcgcggg cggcggcggc      120

tcggcggagc agttggacgc gctggtgaag aaggacaagg tggtggtctt cctcaagggg      180

acgccggagc agccccagtg cggcttcagc aacgccgtgg tgcagatcct gcggctgcac      240

ggcgtccgcg attacgcggc ctacaacgtg ctggacgacc cggagctccg acaaggcatt      300

aaagactatt ccaactggcc caccatcccg caagtgtacc tcaatggcga gtttgtaggg      360

ggctgtgaca ttcttctgca gatgcaccag aatggggact tggtggaaga actgaaaaag      420

ctggggatcc actccgccct tttagatgaa aagaaagacc aagactccaa gtga            474


<210>  28
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Gly Ser Leu Gly Arg Ala Ala Ala Ala Leu Leu Arg Trp Gly 
1               5                   10                  15      


Arg Gly Ala Gly Gly Gly Gly Leu Trp Gly Pro Gly Val Arg Ala Ala 
            20                  25                  30          


Gly Ser Gly Ala Gly Gly Gly Gly Ser Ala Glu Gln Leu Asp Ala Leu 
        35                  40                  45              


Val Lys Lys Asp Lys Val Val Val Phe Leu Lys Gly Thr Pro Glu Gln 
    50                  55                  60                  


Pro Gln Cys Gly Phe Ser Asn Ala Val Val Gln Ile Leu Arg Leu His 
65                  70                  75                  80  


Gly Val Arg Asp Tyr Ala Ala Tyr Asn Val Leu Asp Asp Pro Glu Leu 
                85                  90                  95      


Arg Gln Gly Ile Lys Asp Tyr Ser Asn Trp Pro Thr Ile Pro Gln Val 
            100                 105                 110         


Tyr Leu Asn Gly Glu Phe Val Gly Gly Cys Asp Ile Leu Leu Gln Met 
        115                 120                 125             


His Gln Asn Gly Asp Leu Val Glu Glu Leu Lys Lys Leu Gly Ile His 
    130                 135                 140                 


Ser Ala Leu Leu Asp Glu Lys Lys Asp Gln Asp Ser Lys 
145                 150                 155         


<210>  29
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  29
atggctgcat ggagcccggc cgcggcagcg cctctcctcc gcgggatccg cgggcttcca       60

cttcaccatc ggatgtttgc cactcagact gagggggagc tcagagtgac ccaaattctc      120

aaagaaaagt ttccacgagc tacagctata aaagtcactg acatttcagg aggttgtggg      180

gcgatgtatg aaattaaaat tgaatcagaa gaatttaagg agaagagaac tgtccagcag      240

caccagatgg ttaatcaggc actaaaagaa gaaatcaaag agatgcatgg attgcggata      300

tttacctctg tccccaaacg ctga                                             324


<210>  30
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Ala Trp Ser Pro Ala Ala Ala Ala Pro Leu Leu Arg Gly Ile 
1               5                   10                  15      


Arg Gly Leu Pro Leu His His Arg Met Phe Ala Thr Gln Thr Glu Gly 
            20                  25                  30          


Glu Leu Arg Val Thr Gln Ile Leu Lys Glu Lys Phe Pro Arg Ala Thr 
        35                  40                  45              


Ala Ile Lys Val Thr Asp Ile Ser Gly Gly Cys Gly Ala Met Tyr Glu 
    50                  55                  60                  


Ile Lys Ile Glu Ser Glu Glu Phe Lys Glu Lys Arg Thr Val Gln Gln 
65                  70                  75                  80  


His Gln Met Val Asn Gln Ala Leu Lys Glu Glu Ile Lys Glu Met His 
                85                  90                  95      


Gly Leu Arg Ile Phe Thr Ser Val Pro Lys Arg 
            100                 105         


<210>  31
<211>  306
<212>  DNA
<213>  Homo sapiens

<400>  31
atggctgcat ggagcccggc cgcggcagcg cctctcctcc gcgggatccg cgggcttcca       60

cttcaccatc ggatgtttgc cactcagact gagggggagc tcagagtgac ccaaattctc      120

aaagaaaagt ttccacgagc tacagctata aaagtcactg acatttcagg cactaaaaga      180

agaaatcaaa gagatgcatg gattgcggat atttacctct gtccccaaac gctgaccacg      240

ccctggctgc atagatgctg ctgcttaaga ccttggatga acttcactga catcattctt      300

ccctaa                                                                 306


<210>  32
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Ala Trp Ser Pro Ala Ala Ala Ala Pro Leu Leu Arg Gly Ile 
1               5                   10                  15      


Arg Gly Leu Pro Leu His His Arg Met Phe Ala Thr Gln Thr Glu Gly 
            20                  25                  30          


Glu Leu Arg Val Thr Gln Ile Leu Lys Glu Lys Phe Pro Arg Ala Thr 
        35                  40                  45              


Ala Ile Lys Val Thr Asp Ile Ser Gly Thr Lys Arg Arg Asn Gln Arg 
    50                  55                  60                  


Asp Ala Trp Ile Ala Asp Ile Tyr Leu Cys Pro Gln Thr Leu Thr Thr 
65                  70                  75                  80  


Pro Trp Leu His Arg Cys Cys Cys Leu Arg Pro Trp Met Asn Phe Thr 
                85                  90                  95      


Asp Ile Ile Leu Pro 
            100     


<210>  33
<211>  708
<212>  DNA
<213>  Homo sapiens

<400>  33
atgtggcggg ggagagccgg ggctttgctc cgggtgtggg ggttttggcc gacaggggtt       60

cccagaagga gaccgctaag ctgcgatgct gcgtcgcagg cgggaagcaa ttatccccgc      120

tgttggaact gcggcggccc atggggcccc gggcgggagg acaggttctt ctgcccacag      180

tgccgagcgc tgcaggcacc tgaccccact cgagactact tcagccttat ggactgcaac      240

cgttccttca gagttgatac agcgaagctc cagcacaggt accagcaact gcagcgtctt      300

gtccacccag atttcttcag ccagaggtct cagactgaaa aggacttctc agagaagcat      360

tcgaccctgg tgaatgatgc ctataagacc ctcctggccc ccctgagcag aggactgtac      420

cttctaaagc tccatggaat agagattcct gaaaggacag attatgaaat ggacaggcaa      480

ttcctcatag aaataatgga aatcaatgaa aaactcgcag aagctgaaag tgaagctgcc      540

atgaaagaga ttgaatccat tgtcaaagct aaacagaaag aatttactga caatgtgagc      600

agtgcttttg aacaagatga ctttgaagaa gccaaggaaa ttttgacaaa gatgagatac      660

ttttcaaata tagaagaaaa gatcaagtta aagaagattc ccctttaa                   708


<210>  34
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Trp Arg Gly Arg Ala Gly Ala Leu Leu Arg Val Trp Gly Phe Trp 
1               5                   10                  15      


Pro Thr Gly Val Pro Arg Arg Arg Pro Leu Ser Cys Asp Ala Ala Ser 
            20                  25                  30          


Gln Ala Gly Ser Asn Tyr Pro Arg Cys Trp Asn Cys Gly Gly Pro Trp 
        35                  40                  45              


Gly Pro Gly Arg Glu Asp Arg Phe Phe Cys Pro Gln Cys Arg Ala Leu 
    50                  55                  60                  


Gln Ala Pro Asp Pro Thr Arg Asp Tyr Phe Ser Leu Met Asp Cys Asn 
65                  70                  75                  80  


Arg Ser Phe Arg Val Asp Thr Ala Lys Leu Gln His Arg Tyr Gln Gln 
                85                  90                  95      


Leu Gln Arg Leu Val His Pro Asp Phe Phe Ser Gln Arg Ser Gln Thr 
            100                 105                 110         


Glu Lys Asp Phe Ser Glu Lys His Ser Thr Leu Val Asn Asp Ala Tyr 
        115                 120                 125             


Lys Thr Leu Leu Ala Pro Leu Ser Arg Gly Leu Tyr Leu Leu Lys Leu 
    130                 135                 140                 


His Gly Ile Glu Ile Pro Glu Arg Thr Asp Tyr Glu Met Asp Arg Gln 
145                 150                 155                 160 


Phe Leu Ile Glu Ile Met Glu Ile Asn Glu Lys Leu Ala Glu Ala Glu 
                165                 170                 175     


Ser Glu Ala Ala Met Lys Glu Ile Glu Ser Ile Val Lys Ala Lys Gln 
            180                 185                 190         


Lys Glu Phe Thr Asp Asn Val Ser Ser Ala Phe Glu Gln Asp Asp Phe 
        195                 200                 205             


Glu Glu Ala Lys Glu Ile Leu Thr Lys Met Arg Tyr Phe Ser Asn Ile 
    210                 215                 220                 


Glu Glu Lys Ile Lys Leu Lys Lys Ile Pro Leu 
225                 230                 235 


<210>  35
<211>  2040
<212>  DNA
<213>  Homo sapiens

<400>  35
atgataagtg ccagccgagc tgcagcagcc cgtctcgtgg gcgccgcagc ctcccggggc       60

cctacggccg cccgccacca ggatagctgg aatggcctta gtcatgaggc ttttagactt      120

gtttcaaggc gggattatgc atcagaagca atcaagggag cagttgttgg tattgatttg      180

ggtactacca actcctgcgt ggcagttatg gaaggtaaac aagcaaaggt gctggagaat      240

gccgaaggtg ccagaaccac cccttcagtt gtggccttta cagcagatgg tgagcgactt      300

gttggaatgc cggccaagcg acaggctgtc accaacccaa acaatacatt ttatgctacc      360

aagcgtctca ttggccggcg atatgatgat cctgaagtac agaaagacat taaaaatgtt      420

ccctttaaaa ttgtccgtgc ctccaatggt gatgcctggg ttgaggctca tgggaaattg      480

tattctccga gtcagattgg agcatttgtg ttgatgaaga tgaaagagac tgcagaaaat      540

tacttggggc acacagcaaa aaatgctgtg atcacagtcc cagcttattt caatgactcg      600

cagagacagg ccactaaaga tgctggccag atatctggac tgaatgtgct tcgggtgatt      660

aatgagccca cagctgctgc tcttgcctat ggtctagaca aatcagaaga caaagtcatt      720

gctgtatatg atttaggtgg tggaactttt gatatttcta tcctggaaat tcagaaagga      780

gtatttgagg tgaaatccac aaatggggat accttcttag gtggggaaga ctttgaccag      840

gccttgctac ggcacattgt gaaggagttc aagagagaga caggggttga tttgactaaa      900

gacaacatgg cacttcagag ggtacgggaa gctgctgaaa aggctaaatg tgaactctcc      960

tcatctgtgc agactgacat caatttgccc tatcttacaa tggattcttc tggacccaag     1020

catttgaata tgaagttgac ccgtgctcaa tttgaaggga ttgtcactga tctaatcaga     1080

aggactatcg ctccatgcca aaaagctatg caagatgcag aagtcagcaa gagtgacata     1140

ggagaagtga ttcttgtggg tggcatgact aggatgccca aggttcagca gactgtacag     1200

gatctttttg gcagagcccc aagtaaagct gtcaatcctg atgaggctgt ggccattgga     1260

gctgccattc agggaggtgt gttggccggc gatgtcacgg atgtgctgct ccttgatgtc     1320

actcccctgt ctctgggtat tgaaactcta ggaggtgtct ttaccaaact tattaatagg     1380

aataccacta ttccaaccaa gaagagccag gtattctcta ctgccgctga tggtcaaacg     1440

caagtggaaa ttaaagtgtg tcagggtgaa agagagatgg ctggagacaa caaactcctt     1500

ggacagttta ctttgattgg aattccacca gcccctcgtg gagttcctca gattgaagtt     1560

acatttgaca ttgatgccaa tgggatagta catgtttctg ctaaagataa aggcacagga     1620

cgtgagcagc agattgtaat ccagtcttct ggtggattaa gcaaagatga tattgaaaat     1680

atggttaaaa atgcagagaa atatgctgaa gaagaccggc gaaagaagga acgagttgaa     1740

gcagttaata tggctgaagg aatcattcac gacacagaaa ccaagatgga agaattcaag     1800

gaccaattac ctgctgatga gtgcaacaag ctgaaagaag agatttccaa aatgagggag     1860

ctcctggcta gaaaagacag cgaaacagga gaaaatatta gacaggcagc atcctctctt     1920

cagcaggcat cactgaagct gttcgaaatg gcatacaaaa agatggcatc tgagcgagaa     1980

ggctctggaa gttctggcac tggggaacaa aaggaagatc aaaaggagga aaaacagtaa     2040


<210>  36
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
1               5                   10                  15      


Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
        35                  40                  45              


Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
    50                  55                  60                  


Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
65                  70                  75                  80  


Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                85                  90                  95      


Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
            100                 105                 110         


Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
        115                 120                 125             


Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
    130                 135                 140                 


Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
145                 150                 155                 160 


Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                165                 170                 175     


Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
            180                 185                 190         


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
        195                 200                 205             


Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
    210                 215                 220                 


Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
225                 230                 235                 240 


Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                245                 250                 255     


Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
        275                 280                 285             


Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
    290                 295                 300                 


Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
305                 310                 315                 320 


Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                325                 330                 335     


Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
            340                 345                 350         


Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
        355                 360                 365             


Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
    370                 375                 380                 


Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
385                 390                 395                 400 


Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                405                 410                 415     


Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
            420                 425                 430         


Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
        435                 440                 445             


Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
    450                 455                 460                 


Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
465                 470                 475                 480 


Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                485                 490                 495     


Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
            500                 505                 510         


Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
        515                 520                 525             


Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
    530                 535                 540                 


Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
545                 550                 555                 560 


Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                565                 570                 575     


Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
            580                 585                 590         


Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
        595                 600                 605             


Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
    610                 615                 620                 


Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
625                 630                 635                 640 


Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                645                 650                 655     


Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
            660                 665                 670         


Asp Gln Lys Glu Glu Lys Gln 
        675                 


<210>  37
<211>  390
<212>  DNA
<213>  Homo sapiens

<400>  37
atgtcggctt ccttagtccg ggcaactgtc cgggctgtga gcaagaggaa gctgcagccc       60

acccgggcag ccctcaccct gacaccttca gcagtaaaca agataaaaca acttcttaaa      120

gataagcctg agcatgtagg tgtaaaagtt ggtgtccgaa ccaggggctg taatggcctt      180

tcttatactc tagaatatac aaagacaaaa ggagattctg atgaagaagt tattcaagat      240

ggagtcagag tattcatcga aaagaaagca cagctaacac ttttaggaac agaaatggac      300

tatgttgaag acaaattatc cagtgagttt gtgttcaata acccaaacat caaagggact      360

tgtggctgtg gagaaagctt taatatttga                                       390


<210>  38
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ser Ala Ser Leu Val Arg Ala Thr Val Arg Ala Val Ser Lys Arg 
1               5                   10                  15      


Lys Leu Gln Pro Thr Arg Ala Ala Leu Thr Leu Thr Pro Ser Ala Val 
            20                  25                  30          


Asn Lys Ile Lys Gln Leu Leu Lys Asp Lys Pro Glu His Val Gly Val 
        35                  40                  45              


Lys Val Gly Val Arg Thr Arg Gly Cys Asn Gly Leu Ser Tyr Thr Leu 
    50                  55                  60                  


Glu Tyr Thr Lys Thr Lys Gly Asp Ser Asp Glu Glu Val Ile Gln Asp 
65                  70                  75                  80  


Gly Val Arg Val Phe Ile Glu Lys Lys Ala Gln Leu Thr Leu Leu Gly 
                85                  90                  95      


Thr Glu Met Asp Tyr Val Glu Asp Lys Leu Ser Ser Glu Phe Val Phe 
            100                 105                 110         


Asn Asn Pro Asn Ile Lys Gly Thr Cys Gly Cys Gly Glu Ser Phe Asn 
        115                 120                 125             


Ile 
    


<210>  39
<211>  465
<212>  DNA
<213>  Homo sapiens

<400>  39
atggctgccg cctgggggtc gtccctaacg gccgcgacgc agagagcggt cactccctgg       60

ccgaggggca ggctcctcac ggcctccctg ggaccccagg cgcgtcggga ggcgtcgtcc      120

tccagccccg aggccggcga agggcagatc cgcctcacag acagttgcgt ccagaggctt      180

ttggaaatca ccgaagggtc agaattcctc aggctgcaag tggagggagg tggatgctcc      240

ggattccaat acaaattttc actggataca gttatcaacc ccgacgacag ggtatttgaa      300

cagggtgggg caagagtggt ggttgactct gatagcttgg ccttcgtgaa aggggcccag      360

gtggacttca gccaagaact gatccgaagc tcatttcaag tgttgaacaa tcctcaagca      420

cagcaaggct gctcctgtgg gtcatctttc tctatcaaac tttga                      465


<210>  40
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Ala Ala Trp Gly Ser Ser Leu Thr Ala Ala Thr Gln Arg Ala 
1               5                   10                  15      


Val Thr Pro Trp Pro Arg Gly Arg Leu Leu Thr Ala Ser Leu Gly Pro 
            20                  25                  30          


Gln Ala Arg Arg Glu Ala Ser Ser Ser Ser Pro Glu Ala Gly Glu Gly 
        35                  40                  45              


Gln Ile Arg Leu Thr Asp Ser Cys Val Gln Arg Leu Leu Glu Ile Thr 
    50                  55                  60                  


Glu Gly Ser Glu Phe Leu Arg Leu Gln Val Glu Gly Gly Gly Cys Ser 
65                  70                  75                  80  


Gly Phe Gln Tyr Lys Phe Ser Leu Asp Thr Val Ile Asn Pro Asp Asp 
                85                  90                  95      


Arg Val Phe Glu Gln Gly Gly Ala Arg Val Val Val Asp Ser Asp Ser 
            100                 105                 110         


Leu Ala Phe Val Lys Gly Ala Gln Val Asp Phe Ser Gln Glu Leu Ile 
        115                 120                 125             


Arg Ser Ser Phe Gln Val Leu Asn Asn Pro Gln Ala Gln Gln Gly Cys 
    130                 135                 140                 


Ser Cys Gly Ser Ser Phe Ser Ile Lys Leu 
145                 150                 


<210>  41
<211>  183
<212>  DNA
<213>  Homo sapiens

<400>  41
atggctgccg cctgggggtc gtccctaacg gccgcgacgc agagagcggt cactccctgg       60

ccgaggggca ggctcctcac ggcctccctg ggaccccagg cgcgtcggga ggcgtcgtcc      120

tccagccccg aggccggcga agggcagatc cgcctcacag acagttgcgt ccagggtatt      180

tga                                                                    183


<210>  42
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Ala Ala Trp Gly Ser Ser Leu Thr Ala Ala Thr Gln Arg Ala 
1               5                   10                  15      


Val Thr Pro Trp Pro Arg Gly Arg Leu Leu Thr Ala Ser Leu Gly Pro 
            20                  25                  30          


Gln Ala Arg Arg Glu Ala Ser Ser Ser Ser Pro Glu Ala Gly Glu Gly 
        35                  40                  45              


Gln Ile Arg Leu Thr Asp Ser Cys Val Gln Gly Ile 
    50                  55                  60  


<210>  43
<211>  1071
<212>  DNA
<213>  Homo sapiens

<400>  43
atggcgaccg cggcgctgct tcgaggcgcc actccggggc gcggcggccc ggtctggcgc       60

tggcggctgc gcgcggcccc aaggtgccgc ctggcccaca gctcctgcag tcctggtggc      120

gacccaacgg ccggagcggc ctgggcctgc ttccggctgg acgggcgcac cctgctgcgc      180

gtgcgtggcc ccgacgcggc gcccttcctg ctagggctgc tgaccaatga actgccgctt      240

ccgagtcctg cggccgcggg ggccccgcct gctgcgcgcg cgggctacgc ccacttcctg      300

aacgtgcagg gccggacgct ctatgacgtc atcttgtacg ggctccagga acactcggag      360

gtgtctggct tccttctgga gtgtgacagc tcggtgcagg gcgcgctgca gaagcacctc      420

gcgctataca ggatccggcg gaaggtcacg gtggagccgc acccggagct gcgagtgtgg      480

gcggtgttgc ccagttcccc tgaggcctgc ggggctgcat cgctgcagga gagggcaggg      540

gctgccgcca tcctcatccg cgacccgcga acagcacgca tggggtggcg gctcctcacc      600

caggatgaag gcccagccct ggtgcccggg ggccggctcg gggacttgtg ggattatcac      660

cagcaccgat acctgcaagg cgttcctgag ggggtccgag acttgcctcc tggggtggcc      720

ctgcccctgg agtccaacct ggccttcatg aacggcgtga gcttcaccaa aggctgctac      780

attggccagg agctgacggc ccgcacccac cacatgggcg tcatccgcaa gcgcctcttc      840

cctgtccggt tcttggaccc ccttcccacc agtggcatca cccctggtgc cacggtgctg      900

actgcctcag gacagactgt gggcaagttc agggctggcc agggcaacgt ggggctggcc      960

ctgctgtggt cagagaagat caagggtcct ctgcacatca gagcctctga gggtgcccag     1020

gtggccttag ccgcatctgt gccagactgg tggcctacag tctccaagta g              1071


<210>  44
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Thr Ala Ala Leu Leu Arg Gly Ala Thr Pro Gly Arg Gly Gly 
1               5                   10                  15      


Pro Val Trp Arg Trp Arg Leu Arg Ala Ala Pro Arg Cys Arg Leu Ala 
            20                  25                  30          


His Ser Ser Cys Ser Pro Gly Gly Asp Pro Thr Ala Gly Ala Ala Trp 
        35                  40                  45              


Ala Cys Phe Arg Leu Asp Gly Arg Thr Leu Leu Arg Val Arg Gly Pro 
    50                  55                  60                  


Asp Ala Ala Pro Phe Leu Leu Gly Leu Leu Thr Asn Glu Leu Pro Leu 
65                  70                  75                  80  


Pro Ser Pro Ala Ala Ala Gly Ala Pro Pro Ala Ala Arg Ala Gly Tyr 
                85                  90                  95      


Ala His Phe Leu Asn Val Gln Gly Arg Thr Leu Tyr Asp Val Ile Leu 
            100                 105                 110         


Tyr Gly Leu Gln Glu His Ser Glu Val Ser Gly Phe Leu Leu Glu Cys 
        115                 120                 125             


Asp Ser Ser Val Gln Gly Ala Leu Gln Lys His Leu Ala Leu Tyr Arg 
    130                 135                 140                 


Ile Arg Arg Lys Val Thr Val Glu Pro His Pro Glu Leu Arg Val Trp 
145                 150                 155                 160 


Ala Val Leu Pro Ser Ser Pro Glu Ala Cys Gly Ala Ala Ser Leu Gln 
                165                 170                 175     


Glu Arg Ala Gly Ala Ala Ala Ile Leu Ile Arg Asp Pro Arg Thr Ala 
            180                 185                 190         


Arg Met Gly Trp Arg Leu Leu Thr Gln Asp Glu Gly Pro Ala Leu Val 
        195                 200                 205             


Pro Gly Gly Arg Leu Gly Asp Leu Trp Asp Tyr His Gln His Arg Tyr 
    210                 215                 220                 


Leu Gln Gly Val Pro Glu Gly Val Arg Asp Leu Pro Pro Gly Val Ala 
225                 230                 235                 240 


Leu Pro Leu Glu Ser Asn Leu Ala Phe Met Asn Gly Val Ser Phe Thr 
                245                 250                 255     


Lys Gly Cys Tyr Ile Gly Gln Glu Leu Thr Ala Arg Thr His His Met 
            260                 265                 270         


Gly Val Ile Arg Lys Arg Leu Phe Pro Val Arg Phe Leu Asp Pro Leu 
        275                 280                 285             


Pro Thr Ser Gly Ile Thr Pro Gly Ala Thr Val Leu Thr Ala Ser Gly 
    290                 295                 300                 


Gln Thr Val Gly Lys Phe Arg Ala Gly Gln Gly Asn Val Gly Leu Ala 
305                 310                 315                 320 


Leu Leu Trp Ser Glu Lys Ile Lys Gly Pro Leu His Ile Arg Ala Ser 
                325                 330                 335     


Glu Gly Ala Gln Val Ala Leu Ala Ala Ser Val Pro Asp Trp Trp Pro 
            340                 345                 350         


Thr Val Ser Lys 
        355     


<210>  45
<211>  960
<212>  DNA
<213>  Homo sapiens

<400>  45
atggggattt ggcagcgtct gctgcttttt ggtggggtgt cgctccgggc tggtggcggg       60

gccactgccc cgcttggggg aagccgagcg atggtttgtg ggcgccagtt gtctggcgcc      120

gggagtgaga ccctaaaaca aagaagaaca caaatcatgt cccgaggact tccaaagcag      180

aaaccgatag aaggtgttaa acaagttata gttgtggctt ctggaaaggg tggagtcgga      240

aaatctacta cagcagtgaa tcttgcactt gcactagcag cgaacgattc gtccaaggcc      300

attggtttgc tagatgtgga tgtgtatgga ccttcagttc caaagatgat gaatctgaaa      360

ggaaatccgg aattatcaca gagcaaccta atgaggcctc tcttgaatta tggtattgct      420

tgtatgtcta tgggctttct ggttgaagaa agtgaaccag tagtttggag aggccttatg      480

gtaatgtcgg ccattgagaa attgttgagg caggtagatt ggggtcaact ggactactta      540

gttgtagaca tgccaccagg aactggagat gtgcagttat cagtctcaca gaatattcct      600

ataacaggtg ctgtgattgt ctccacgccc caggacatcg cattgatgga tgcacacaag      660

ggtgctgaga tgtttcgcag agtccacgtg cccgtccttg gccttgtcca aaacatgagt      720

gttttccagt gtccaaaatg taaacacaaa actcatattt ttggtgctga tggtgcaagg      780

aaactagcac agacccttgg tcttgaagtt ctaggagaca ttcccttaca ccttaatata      840

agggaagctt cagatacagg ccagccaatt gtgttttcac agcctgaaag tgatgaggcc      900

aaagcttact tgaggattgc tgtggaagtg gtaagaagat tgccatcacc ttcagaatga      960


<210>  46
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Ile Trp Gln Arg Leu Leu Leu Phe Gly Gly Val Ser Leu Arg 
1               5                   10                  15      


Ala Gly Gly Gly Ala Thr Ala Pro Leu Gly Gly Ser Arg Ala Met Val 
            20                  25                  30          


Cys Gly Arg Gln Leu Ser Gly Ala Gly Ser Glu Thr Leu Lys Gln Arg 
        35                  40                  45              


Arg Thr Gln Ile Met Ser Arg Gly Leu Pro Lys Gln Lys Pro Ile Glu 
    50                  55                  60                  


Gly Val Lys Gln Val Ile Val Val Ala Ser Gly Lys Gly Gly Val Gly 
65                  70                  75                  80  


Lys Ser Thr Thr Ala Val Asn Leu Ala Leu Ala Leu Ala Ala Asn Asp 
                85                  90                  95      


Ser Ser Lys Ala Ile Gly Leu Leu Asp Val Asp Val Tyr Gly Pro Ser 
            100                 105                 110         


Val Pro Lys Met Met Asn Leu Lys Gly Asn Pro Glu Leu Ser Gln Ser 
        115                 120                 125             


Asn Leu Met Arg Pro Leu Leu Asn Tyr Gly Ile Ala Cys Met Ser Met 
    130                 135                 140                 


Gly Phe Leu Val Glu Glu Ser Glu Pro Val Val Trp Arg Gly Leu Met 
145                 150                 155                 160 


Val Met Ser Ala Ile Glu Lys Leu Leu Arg Gln Val Asp Trp Gly Gln 
                165                 170                 175     


Leu Asp Tyr Leu Val Val Asp Met Pro Pro Gly Thr Gly Asp Val Gln 
            180                 185                 190         


Leu Ser Val Ser Gln Asn Ile Pro Ile Thr Gly Ala Val Ile Val Ser 
        195                 200                 205             


Thr Pro Gln Asp Ile Ala Leu Met Asp Ala His Lys Gly Ala Glu Met 
    210                 215                 220                 


Phe Arg Arg Val His Val Pro Val Leu Gly Leu Val Gln Asn Met Ser 
225                 230                 235                 240 


Val Phe Gln Cys Pro Lys Cys Lys His Lys Thr His Ile Phe Gly Ala 
                245                 250                 255     


Asp Gly Ala Arg Lys Leu Ala Gln Thr Leu Gly Leu Glu Val Leu Gly 
            260                 265                 270         


Asp Ile Pro Leu His Leu Asn Ile Arg Glu Ala Ser Asp Thr Gly Gln 
        275                 280                 285             


Pro Ile Val Phe Ser Gln Pro Glu Ser Asp Glu Ala Lys Ala Tyr Leu 
    290                 295                 300                 


Arg Ile Ala Val Glu Val Val Arg Arg Leu Pro Ser Pro Ser Glu 
305                 310                 315                 


<210>  47
<211>  672
<212>  DNA
<213>  Homo sapiens

<400>  47
atgtccaagg ccattggttt gctagatgtg gatgtgtatg gaccttcagt tccaaagatg       60

atgaatctga aaggaaatcc ggaattatca cagagcaacc taatgaggcc tctcttgaat      120

tatggtattg cttgtatgtc tatgggcttt ctggttgaag aaagtgaacc agtagtttgg      180

agaggcctta tggtaatgtc ggccattgag aaattgttga ggcaggtaga ttggggtcaa      240

ctggactact tagttgtaga catgccacca ggaactggag atgtgcagtt atcagtctca      300

cagaatattc ctataacagg tgctgtgatt gtctccacgc cccaggacat cgcattgatg      360

gatgcacaca agggtgctga gatgtttcgc agagtccacg tgcccgtcct tggccttgtc      420

caaaacatga gtgttttcca gtgtccaaaa tgtaaacaca aaactcatat ttttggtgct      480

gatggtgcaa ggaaactagc acagaccctt ggtcttgaag ttctaggaga cattccctta      540

caccttaata taagggaagc ttcagataca ggccagccaa ttgtgttttc acagcctgaa      600

agtgatgagg ccaaagctta cttgaggatt gctgtggaag tggtaagaag attgccatca      660

ccttcagaat ga                                                          672


<210>  48
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Lys Ala Ile Gly Leu Leu Asp Val Asp Val Tyr Gly Pro Ser 
1               5                   10                  15      


Val Pro Lys Met Met Asn Leu Lys Gly Asn Pro Glu Leu Ser Gln Ser 
            20                  25                  30          


Asn Leu Met Arg Pro Leu Leu Asn Tyr Gly Ile Ala Cys Met Ser Met 
        35                  40                  45              


Gly Phe Leu Val Glu Glu Ser Glu Pro Val Val Trp Arg Gly Leu Met 
    50                  55                  60                  


Val Met Ser Ala Ile Glu Lys Leu Leu Arg Gln Val Asp Trp Gly Gln 
65                  70                  75                  80  


Leu Asp Tyr Leu Val Val Asp Met Pro Pro Gly Thr Gly Asp Val Gln 
                85                  90                  95      


Leu Ser Val Ser Gln Asn Ile Pro Ile Thr Gly Ala Val Ile Val Ser 
            100                 105                 110         


Thr Pro Gln Asp Ile Ala Leu Met Asp Ala His Lys Gly Ala Glu Met 
        115                 120                 125             


Phe Arg Arg Val His Val Pro Val Leu Gly Leu Val Gln Asn Met Ser 
    130                 135                 140                 


Val Phe Gln Cys Pro Lys Cys Lys His Lys Thr His Ile Phe Gly Ala 
145                 150                 155                 160 


Asp Gly Ala Arg Lys Leu Ala Gln Thr Leu Gly Leu Glu Val Leu Gly 
                165                 170                 175     


Asp Ile Pro Leu His Leu Asn Ile Arg Glu Ala Ser Asp Thr Gly Gln 
            180                 185                 190         


Pro Ile Val Phe Ser Gln Pro Glu Ser Asp Glu Ala Lys Ala Tyr Leu 
        195                 200                 205             


Arg Ile Ala Val Glu Val Val Arg Arg Leu Pro Ser Pro Ser Glu 
    210                 215                 220             


<210>  49
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  49
atgccaccag gaactggaga tgtgcagtta tcagtctcac agaatattcc tataacaggt       60

gctgtgattg tctccacgcc ccaggacatc gcattgatgg atgcacacaa gggtgctgag      120

atgtttcgca gagtccacgt gcccgtcctt ggccttgtcc aaaacatgag tgttttccag      180

tgtccaaaat gtaaacacaa aactcatatt tttggtgctg atggtgcaag gaaactagca      240

cagacccttg gtcttgaagt tctaggagac attcccttac accttaatat aagggaagct      300

tcagatacag gccagccaat tgtgttttca cagcctgaaa gtgatgaggc caaagcttac      360

ttgaggattg ctgtggaagt ggtaagaaga ttgccatcac cttcagaatg a               411


<210>  50
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Pro Pro Gly Thr Gly Asp Val Gln Leu Ser Val Ser Gln Asn Ile 
1               5                   10                  15      


Pro Ile Thr Gly Ala Val Ile Val Ser Thr Pro Gln Asp Ile Ala Leu 
            20                  25                  30          


Met Asp Ala His Lys Gly Ala Glu Met Phe Arg Arg Val His Val Pro 
        35                  40                  45              


Val Leu Gly Leu Val Gln Asn Met Ser Val Phe Gln Cys Pro Lys Cys 
    50                  55                  60                  


Lys His Lys Thr His Ile Phe Gly Ala Asp Gly Ala Arg Lys Leu Ala 
65                  70                  75                  80  


Gln Thr Leu Gly Leu Glu Val Leu Gly Asp Ile Pro Leu His Leu Asn 
                85                  90                  95      


Ile Arg Glu Ala Ser Asp Thr Gly Gln Pro Ile Val Phe Ser Gln Pro 
            100                 105                 110         


Glu Ser Asp Glu Ala Lys Ala Tyr Leu Arg Ile Ala Val Glu Val Val 
        115                 120                 125             


Arg Arg Leu Pro Ser Pro Ser Glu 
    130                 135     


<210>  51
<211>  1095
<212>  DNA
<213>  Homo sapiens

<400>  51
atggagttgg aggggcgggg tgctggcggt gtggcggggg ggccggcggc agggcccggg       60

cggagccccg gggagtcggc gctgctggac gggtggctgc agcggggcgt gggccggggg      120

gccggcggcg gggaggccgg ggcctgcagg cccccggtac gacaagatcc ggactccggc      180

ccggactacg aggcgctgcc ggctggagcc actgtcacca cgcacatggt ggcaggcgcc      240

gtggcaggga tcctggagca ctgcgtgatg taccccatcg actgcgtcaa gacccggatg      300

cagagtctac agcctgaccc agctgcccgc tatcgcaatg tgttggaggc cctctggagg      360

attataagaa cggagggcct atggaggccc atgagggggc tgaacgtcac agcaacaggc      420

gcagggcctg cccacgccct ttattttgcc tgctacgaaa agttaaaaaa gacattgagt      480

gatgtaatcc accctggggg caatagccat attgccaatg gtgcggccgg gtgtgtggca      540

acattacttc atgatgcagc catgaaccct gcggaagtgg tcaagcagag gatgcagatg      600

tacaactcac cataccaccg ggtgacagac tgtgtacggg cagtgtggca aaatgaaggg      660

gccggggcct tttaccgcag ctacaccacc cagctgacca tgaacgttcc tttccaagcc      720

attcacttca tgacctatga attcctgcag gagcacttta acccccagag acggtacaac      780

ccaagctccc acgtcctctc tggagcttgc gcaggagctg tagctgccgc agccacaacc      840

ccactggacg tttgcaaaac actgctcaac acccaggagt ccttggcttt gaactcacac      900

attacaggac atatcacagg catggctagt gccttcagga cggtatatca agtaggtggg      960

gtgaccgcct atttccgagg ggtgcaggcc agagtaattt accagatccc ctccacagcc     1020

atcgcatggt ctgtgtatga gttcttcaaa tacctaatca ctaaaaggca agaagagtgg     1080

agggctggca agtga                                                      1095


<210>  52
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Glu Leu Glu Gly Arg Gly Ala Gly Gly Val Ala Gly Gly Pro Ala 
1               5                   10                  15      


Ala Gly Pro Gly Arg Ser Pro Gly Glu Ser Ala Leu Leu Asp Gly Trp 
            20                  25                  30          


Leu Gln Arg Gly Val Gly Arg Gly Ala Gly Gly Gly Glu Ala Gly Ala 
        35                  40                  45              


Cys Arg Pro Pro Val Arg Gln Asp Pro Asp Ser Gly Pro Asp Tyr Glu 
    50                  55                  60                  


Ala Leu Pro Ala Gly Ala Thr Val Thr Thr His Met Val Ala Gly Ala 
65                  70                  75                  80  


Val Ala Gly Ile Leu Glu His Cys Val Met Tyr Pro Ile Asp Cys Val 
                85                  90                  95      


Lys Thr Arg Met Gln Ser Leu Gln Pro Asp Pro Ala Ala Arg Tyr Arg 
            100                 105                 110         


Asn Val Leu Glu Ala Leu Trp Arg Ile Ile Arg Thr Glu Gly Leu Trp 
        115                 120                 125             


Arg Pro Met Arg Gly Leu Asn Val Thr Ala Thr Gly Ala Gly Pro Ala 
    130                 135                 140                 


His Ala Leu Tyr Phe Ala Cys Tyr Glu Lys Leu Lys Lys Thr Leu Ser 
145                 150                 155                 160 


Asp Val Ile His Pro Gly Gly Asn Ser His Ile Ala Asn Gly Ala Ala 
                165                 170                 175     


Gly Cys Val Ala Thr Leu Leu His Asp Ala Ala Met Asn Pro Ala Glu 
            180                 185                 190         


Val Val Lys Gln Arg Met Gln Met Tyr Asn Ser Pro Tyr His Arg Val 
        195                 200                 205             


Thr Asp Cys Val Arg Ala Val Trp Gln Asn Glu Gly Ala Gly Ala Phe 
    210                 215                 220                 


Tyr Arg Ser Tyr Thr Thr Gln Leu Thr Met Asn Val Pro Phe Gln Ala 
225                 230                 235                 240 


Ile His Phe Met Thr Tyr Glu Phe Leu Gln Glu His Phe Asn Pro Gln 
                245                 250                 255     


Arg Arg Tyr Asn Pro Ser Ser His Val Leu Ser Gly Ala Cys Ala Gly 
            260                 265                 270         


Ala Val Ala Ala Ala Ala Thr Thr Pro Leu Asp Val Cys Lys Thr Leu 
        275                 280                 285             


Leu Asn Thr Gln Glu Ser Leu Ala Leu Asn Ser His Ile Thr Gly His 
    290                 295                 300                 


Ile Thr Gly Met Ala Ser Ala Phe Arg Thr Val Tyr Gln Val Gly Gly 
305                 310                 315                 320 


Val Thr Ala Tyr Phe Arg Gly Val Gln Ala Arg Val Ile Tyr Gln Ile 
                325                 330                 335     


Pro Ser Thr Ala Ile Ala Trp Ser Val Tyr Glu Phe Phe Lys Tyr Leu 
            340                 345                 350         


Ile Thr Lys Arg Gln Glu Glu Trp Arg Ala Gly Lys 
        355                 360                 


<210>  53
<211>  1476
<212>  DNA
<213>  Homo sapiens

<400>  53
atggcttcgc gctgctggcg ctggtggggc tggtcggcgt ggcctcggac ccggctgcct       60

cccgccggga gcaccccgag cttctgccac catttctcca cacaggagaa gaccccccag      120

atctgtgtgg tgggcagtgg cccagctggc ttctacacgg cccaacacct gctaaagcac      180

ccccaggccc acgtggacat ctacgagaaa cagcctgtgc cctttggcct ggtgcgcttt      240

ggtgtggcgc ctgatcaccc cgaggtgaag aatgtcatca acacatttac ccagacggcc      300

cattctggcc gctgtgcctt ctggggcaac gtggaggtgg gcagggacgt gacggtgccg      360

gagctgcggg aggcctacca cgctgtggtg ctgagctacg gggcagagga ccatcgggcc      420

ctggaaattc ctggtgagga gctgccaggt gtgtgctccg cccgggcctt cgtgggctgg      480

tacaacgggc ttcctgagaa ccaggagctg gagccagacc tgagctgtga cacagccgtg      540

attctggggc aggggaacgt ggctctggac gtggcccgca tcctactgac cccacctgag      600

cacctggaga gaacggacat cacgaaggca gccctgggtg tactgaggca gagtcgagtg      660

aagacagtgt ggctagtggg ccggcgtgga cccctgcaag tggccttcac cattaaggag      720

cttcgggaga tgattcagtt accgggagcc cggcccattt tggatcctgt ggatttcttg      780

ggtctccagg acaagatcaa ggaggtcccc cgcccgagga agcggctgac ggaactgctg      840

cttcgaacgg ccacagagaa gccagggccg gcggaagctg cccgccaggc atcggcctcc      900

cgtgcctggg gcctccgctt tttccgaagc ccccagcagg tgctgccctc accagatggg      960

cggcgggcag caggtgtccg cctagcagtc actagactgg agggtgtcga tgaggccacc     1020

cgtgcagtgc ccacgggaga catggaagac ctcccttgtg ggctggtgct cagcagcatt     1080

gggtataaga gccgccctgt cgacccaagc gtgccctttg actccaagct tggggtcatc     1140

cccaatgtgg agggccgggt tatggatgtg ccaggcctct actgcagcgg ctgggtgaag     1200

agaggaccta caggtgtcat agccacaacc atgactgaca gcttcctcac cggccagatg     1260

ctgctgcagg acctgaaggc tgggttgctc ccctctggcc ccaggcctgg ctacgcagcc     1320

atccaggccc tgctcagcag ccgaggggtc cggccagtct ctttctcaga ctgggagaag     1380

ctggatgccg aggaggtggc ccggggccag ggcacgggga agcccaggga gaagctggtg     1440

gatcctcagg agatgctgcg cctcctgggc cactga                               1476


<210>  54
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
1               5                   10                  15      


Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe 
            20                  25                  30          


Ser Thr Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro 
        35                  40                  45              


Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys His Pro Gln Ala His 
    50                  55                  60                  


Val Asp Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe 
65                  70                  75                  80  


Gly Val Ala Pro Asp His Pro Glu Val Lys Asn Val Ile Asn Thr Phe 
                85                  90                  95      


Thr Gln Thr Ala His Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu 
            100                 105                 110         


Val Gly Arg Asp Val Thr Val Pro Glu Leu Arg Glu Ala Tyr His Ala 
        115                 120                 125             


Val Val Leu Ser Tyr Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro 
    130                 135                 140                 


Gly Glu Glu Leu Pro Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp 
145                 150                 155                 160 


Tyr Asn Gly Leu Pro Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys 
                165                 170                 175     


Asp Thr Ala Val Ile Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala 
            180                 185                 190         


Arg Ile Leu Leu Thr Pro Pro Glu His Leu Glu Arg Thr Asp Ile Thr 
        195                 200                 205             


Lys Ala Ala Leu Gly Val Leu Arg Gln Ser Arg Val Lys Thr Val Trp 
    210                 215                 220                 


Leu Val Gly Arg Arg Gly Pro Leu Gln Val Ala Phe Thr Ile Lys Glu 
225                 230                 235                 240 


Leu Arg Glu Met Ile Gln Leu Pro Gly Ala Arg Pro Ile Leu Asp Pro 
                245                 250                 255     


Val Asp Phe Leu Gly Leu Gln Asp Lys Ile Lys Glu Val Pro Arg Pro 
            260                 265                 270         


Arg Lys Arg Leu Thr Glu Leu Leu Leu Arg Thr Ala Thr Glu Lys Pro 
        275                 280                 285             


Gly Pro Ala Glu Ala Ala Arg Gln Ala Ser Ala Ser Arg Ala Trp Gly 
    290                 295                 300                 


Leu Arg Phe Phe Arg Ser Pro Gln Gln Val Leu Pro Ser Pro Asp Gly 
305                 310                 315                 320 


Arg Arg Ala Ala Gly Val Arg Leu Ala Val Thr Arg Leu Glu Gly Val 
                325                 330                 335     


Asp Glu Ala Thr Arg Ala Val Pro Thr Gly Asp Met Glu Asp Leu Pro 
            340                 345                 350         


Cys Gly Leu Val Leu Ser Ser Ile Gly Tyr Lys Ser Arg Pro Val Asp 
        355                 360                 365             


Pro Ser Val Pro Phe Asp Ser Lys Leu Gly Val Ile Pro Asn Val Glu 
    370                 375                 380                 


Gly Arg Val Met Asp Val Pro Gly Leu Tyr Cys Ser Gly Trp Val Lys 
385                 390                 395                 400 


Arg Gly Pro Thr Gly Val Ile Ala Thr Thr Met Thr Asp Ser Phe Leu 
                405                 410                 415     


Thr Gly Gln Met Leu Leu Gln Asp Leu Lys Ala Gly Leu Leu Pro Ser 
            420                 425                 430         


Gly Pro Arg Pro Gly Tyr Ala Ala Ile Gln Ala Leu Leu Ser Ser Arg 
        435                 440                 445             


Gly Val Arg Pro Val Ser Phe Ser Asp Trp Glu Lys Leu Asp Ala Glu 
    450                 455                 460                 


Glu Val Ala Arg Gly Gln Gly Thr Gly Lys Pro Arg Glu Lys Leu Val 
465                 470                 475                 480 


Asp Pro Gln Glu Met Leu Arg Leu Leu Gly His 
                485                 490     


<210>  55
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
1               5                   10                  15      


Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe 
            20                  25                  30          


Ser Thr Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro 
        35                  40                  45              


Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys His Pro Gln Ala His 
    50                  55                  60                  


Val Asp Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe 
65                  70                  75                  80  


Gly Val Ala Pro Asp His Pro Glu Val Lys Asn Val Ile Asn Thr Phe 
                85                  90                  95      


Thr Gln Thr Ala His Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu 
            100                 105                 110         


Val Gly Arg Asp Val Thr Val Pro Glu Leu Arg Glu Ala Tyr His Ala 
        115                 120                 125             


Val Val Leu Ser Tyr Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro 
    130                 135                 140                 


Gly Glu Glu Leu Pro Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp 
145                 150                 155                 160 


Tyr Asn Gly Leu Pro Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys 
                165                 170                 175     


Asp Thr Ala Val Ile Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala 
            180                 185                 190         


Arg Ile Leu Leu Thr Pro Pro Glu His Leu Glu Ala Leu Leu Leu Cys 
        195                 200                 205             


Gln Arg Thr Asp Ile Thr Lys Ala Ala Leu Gly Val Leu Arg Gln Ser 
    210                 215                 220                 


Arg Val Lys Thr Val Trp Leu Val Gly Arg Arg Gly Pro Leu Gln Val 
225                 230                 235                 240 


Ala Phe Thr Ile Lys Glu Leu Arg Glu Met Ile Gln Leu Pro Gly Ala 
                245                 250                 255     


Arg Pro Ile Leu Asp Pro Val Asp Phe Leu Gly Leu Gln Asp Lys Ile 
            260                 265                 270         


Lys Glu Val Pro Arg Pro Arg Lys Arg Leu Thr Glu Leu Leu Leu Arg 
        275                 280                 285             


Thr Ala Thr Glu Lys Pro Gly Pro Ala Glu Ala Ala Arg Gln Ala Ser 
    290                 295                 300                 


Ala Ser Arg Ala Trp Gly Leu Arg Phe Phe Arg Ser Pro Gln Gln Val 
305                 310                 315                 320 


Leu Pro Ser Pro Asp Gly Arg Arg Ala Ala Gly Val Arg Leu Ala Val 
                325                 330                 335     


Thr Arg Leu Glu Gly Val Asp Glu Ala Thr Arg Ala Val Pro Thr Gly 
            340                 345                 350         


Asp Met Glu Asp Leu Pro Cys Gly Leu Val Leu Ser Ser Ile Gly Tyr 
        355                 360                 365             


Lys Ser Arg Pro Val Asp Pro Ser Val Pro Phe Asp Ser Lys Leu Gly 
    370                 375                 380                 


Val Ile Pro Asn Val Glu Gly Arg Val Met Asp Val Pro Gly Leu Tyr 
385                 390                 395                 400 


Cys Ser Gly Trp Val Lys Arg Gly Pro Thr Gly Val Ile Ala Thr Thr 
                405                 410                 415     


Met Thr Asp Ser Phe Leu Thr Gly Gln Met Leu Leu Gln Asp Leu Lys 
            420                 425                 430         


Ala Gly Leu Leu Pro Ser Gly Pro Arg Pro Gly Tyr Ala Ala Ile Gln 
        435                 440                 445             


Ala Leu Leu Ser Ser Arg Gly Val Arg Pro Val Ser Phe Ser Asp Trp 
    450                 455                 460                 


Glu Lys Leu Asp Ala Glu Glu Val Ala Arg Gly Gln Gly Thr Gly Lys 
465                 470                 475                 480 


Pro Arg Glu Lys Leu Val Asp Pro Gln Glu Met Leu Arg Leu Leu Gly 
                485                 490                 495     


His 
    


<210>  56
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
1               5                   10                  15      


Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe 
            20                  25                  30          


Ser Thr Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro 
        35                  40                  45              


Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys His Pro Gln Ala His 
    50                  55                  60                  


Val Asp Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe 
65                  70                  75                  80  


Gly Val Ala Pro Asp His Pro Glu Val Lys Asn Val Ile Asn Thr Phe 
                85                  90                  95      


Thr Gln Thr Ala His Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu 
            100                 105                 110         


Val Gly Arg Asp Val Thr Val Pro Glu Leu Arg Glu Ala Tyr His Ala 
        115                 120                 125             


Val Val Leu Ser Tyr Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro 
    130                 135                 140                 


Gly Glu Glu Leu Pro Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp 
145                 150                 155                 160 


Tyr Asn Gly Leu Pro Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys 
                165                 170                 175     


Asp Thr Ala Val Ile Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala 
            180                 185                 190         


Arg Ile Leu Leu Thr Pro Pro Glu His Leu Glu Ala Leu Leu Leu Cys 
        195                 200                 205             


Gln Arg Thr Asp Ile Thr Lys Ala Ala Leu Gly Val Leu Arg Gln Ser 
    210                 215                 220                 


Arg Val Lys Thr Val Trp Leu Val Gly Arg Arg Gly Pro Leu Gln Val 
225                 230                 235                 240 


Ala Phe Thr Ile Lys Glu Leu Arg Glu Met Ile Gln Leu Pro Gly Ala 
                245                 250                 255     


Arg Pro Ile Leu Asp Pro Val Asp Phe Leu Gly Leu Gln Asp Lys Ile 
            260                 265                 270         


Lys Glu Val Pro Arg Pro Arg Lys Arg Leu Thr Glu Leu Leu Leu Arg 
        275                 280                 285             


Thr Ala Thr Glu Lys Pro Gly Pro Ala Glu Ala Ala Arg Gln Ala Ser 
    290                 295                 300                 


Ala Ser Arg Ala Trp Gly Leu Arg Phe Phe Arg Ser Pro Gln Gln Val 
305                 310                 315                 320 


Leu Pro Ser Pro Asp Gly Arg Arg Ala Ala Gly Val Arg Leu Ala Val 
                325                 330                 335     


Thr Arg Leu Glu Gly Val Asp Glu Ala Thr Arg Ala Val Pro Thr Gly 
            340                 345                 350         


Asp Met Glu Asp Leu Pro Cys Gly Leu Val Leu Ser Ser Ile Gly Tyr 
        355                 360                 365             


Lys Ser Arg Pro Val Asp Pro Ser Val Pro Phe Asp Ser Lys Leu Gly 
    370                 375                 380                 


Val Ile Pro Asn Val Glu Gly Arg Val Met Asp Val Pro Gly Leu Tyr 
385                 390                 395                 400 


Cys Ser Gly Trp Val Lys Arg Gly Pro Thr Gly Val Ile Ala Thr Thr 
                405                 410                 415     


Met Thr Asp Ser Phe Leu Thr Gly Gln Met Leu Leu Gln Asp Leu Lys 
            420                 425                 430         


Ala Gly Leu Leu Pro Ser Gly Pro Arg Pro Gly Tyr Ala Ala Ile Gln 
        435                 440                 445             


Ala Leu Leu Ser Ser Arg Gly Val Arg Pro Val Ser Phe Ser Asp Trp 
    450                 455                 460                 


Glu Lys Leu Asp Ala Glu Glu Val Ala Arg Gly Gln Gly Thr Gly Lys 
465                 470                 475                 480 


Pro Arg Glu Lys Leu Val Asp Pro Gln Glu Met Leu Arg Leu Leu Gly 
                485                 490                 495     


His 
    


<210>  57
<211>  1605
<212>  DNA
<213>  Homo sapiens

<400>  57
atggcttcgc gctgctggcg ctggtggggc tggtcggcgt ggcctcggac ccggctgcct       60

cccgccggga gcaccccgag cttctgccac catttctcca cacaggagaa gaccccccag      120

atctgtgtgg tgggcagtgg cccagctggc ttctacacgg cccaacacct gctaaagagg      180

gtggaagcct tgtgttctca gcccagggtc ctgaactctc ctgctctgtc tggggaaggg      240

gaggacctgg gggcgtccca gcctctctct ctcgacccca ccagctgcca ccctgttccc      300

cagcagcacc cccaggccca cgtggacatc tacgagaaac agcctgtgcc ctttggcctg      360

gtgcgctttg gtgtggcgcc tgatcacccc gaggtgaaga atgtcatcaa cacatttacc      420

cagacggccc attctggccg ctgtgccttc tggggcaacg tggaggtggg cagggacgtg      480

acggtgccgg agctgcggga ggcctaccac gctgtggtgc tgagctacgg ggcagaggac      540

catcgggccc tggaaattcc tggtgaggag ctgccaggtg tgtgctccgc ccgggccttc      600

gtgggctggt acaacgggct tcctgagaac caggagctgg agccagacct gagctgtgac      660

acagccgtga ttctggggca ggggaacgtg gctctggacg tggcccgcat cctactgacc      720

ccacctgagc acctggagag aacggacatc acgaaggcag ccctgggtgt actgaggcag      780

agtcgagtga agacagtgtg gctagtgggc cggcgtggac ccctgcaagt ggccttcacc      840

attaaggagc ttcgggagat gattcagtta ccgggagccc ggcccatttt ggatcctgtg      900

gatttcttgg gtctccagga caagatcaag gaggtccccc gcccgaggaa gcggctgacg      960

gaactgctgc ttcgaacggc cacagagaag ccagggccgg cggaagctgc ccgccaggca     1020

tcggcctccc gtgcctgggg cctccgcttt ttccgaagcc cccagcaggt gctgccctca     1080

ccagatgggc ggcgggcagc aggtgtccgc ctagcagtca ctagactgga gggtgtcgat     1140

gaggccaccc gtgcagtgcc cacgggagac atggaagacc tcccttgtgg gctggtgctc     1200

agcagcattg ggtataagag ccgccctgtc gacccaagcg tgccctttga ctccaagctt     1260

ggggtcatcc ccaatgtgga gggccgggtt atggatgtgc caggcctcta ctgcagcggc     1320

tgggtgaaga gaggacctac aggtgtcata gccacaacca tgactgacag cttcctcacc     1380

ggccagatgc tgctgcagga cctgaaggct gggttgctcc cctctggccc caggcctggc     1440

tacgcagcca tccaggccct gctcagcagc cgaggggtcc ggccagtctc tttctcagac     1500

tgggagaagc tggatgccga ggaggtggcc cggggccagg gcacggggaa gcccagggag     1560

aagctggtgg atcctcagga gatgctgcgc ctcctgggcc actga                     1605


<210>  58
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
1               5                   10                  15      


Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe 
            20                  25                  30          


Ser Thr Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro 
        35                  40                  45              


Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys Arg Val Glu Ala Leu 
    50                  55                  60                  


Cys Ser Gln Pro Arg Val Leu Asn Ser Pro Ala Leu Ser Gly Glu Gly 
65                  70                  75                  80  


Glu Asp Leu Gly Ala Ser Gln Pro Leu Ser Leu Asp Pro Thr Ser Cys 
                85                  90                  95      


His Pro Val Pro Gln Gln His Pro Gln Ala His Val Asp Ile Tyr Glu 
            100                 105                 110         


Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe Gly Val Ala Pro Asp 
        115                 120                 125             


His Pro Glu Val Lys Asn Val Ile Asn Thr Phe Thr Gln Thr Ala His 
    130                 135                 140                 


Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu Val Gly Arg Asp Val 
145                 150                 155                 160 


Thr Val Pro Glu Leu Arg Glu Ala Tyr His Ala Val Val Leu Ser Tyr 
                165                 170                 175     


Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro Gly Glu Glu Leu Pro 
            180                 185                 190         


Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp Tyr Asn Gly Leu Pro 
        195                 200                 205             


Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys Asp Thr Ala Val Ile 
    210                 215                 220                 


Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala Arg Ile Leu Leu Thr 
225                 230                 235                 240 


Pro Pro Glu His Leu Glu Arg Thr Asp Ile Thr Lys Ala Ala Leu Gly 
                245                 250                 255     


Val Leu Arg Gln Ser Arg Val Lys Thr Val Trp Leu Val Gly Arg Arg 
            260                 265                 270         


Gly Pro Leu Gln Val Ala Phe Thr Ile Lys Glu Leu Arg Glu Met Ile 
        275                 280                 285             


Gln Leu Pro Gly Ala Arg Pro Ile Leu Asp Pro Val Asp Phe Leu Gly 
    290                 295                 300                 


Leu Gln Asp Lys Ile Lys Glu Val Pro Arg Pro Arg Lys Arg Leu Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Arg Thr Ala Thr Glu Lys Pro Gly Pro Ala Glu Ala 
                325                 330                 335     


Ala Arg Gln Ala Ser Ala Ser Arg Ala Trp Gly Leu Arg Phe Phe Arg 
            340                 345                 350         


Ser Pro Gln Gln Val Leu Pro Ser Pro Asp Gly Arg Arg Ala Ala Gly 
        355                 360                 365             


Val Arg Leu Ala Val Thr Arg Leu Glu Gly Val Asp Glu Ala Thr Arg 
    370                 375                 380                 


Ala Val Pro Thr Gly Asp Met Glu Asp Leu Pro Cys Gly Leu Val Leu 
385                 390                 395                 400 


Ser Ser Ile Gly Tyr Lys Ser Arg Pro Val Asp Pro Ser Val Pro Phe 
                405                 410                 415     


Asp Ser Lys Leu Gly Val Ile Pro Asn Val Glu Gly Arg Val Met Asp 
            420                 425                 430         


Val Pro Gly Leu Tyr Cys Ser Gly Trp Val Lys Arg Gly Pro Thr Gly 
        435                 440                 445             


Val Ile Ala Thr Thr Met Thr Asp Ser Phe Leu Thr Gly Gln Met Leu 
    450                 455                 460                 


Leu Gln Asp Leu Lys Ala Gly Leu Leu Pro Ser Gly Pro Arg Pro Gly 
465                 470                 475                 480 


Tyr Ala Ala Ile Gln Ala Leu Leu Ser Ser Arg Gly Val Arg Pro Val 
                485                 490                 495     


Ser Phe Ser Asp Trp Glu Lys Leu Asp Ala Glu Glu Val Ala Arg Gly 
            500                 505                 510         


Gln Gly Thr Gly Lys Pro Arg Glu Lys Leu Val Asp Pro Gln Glu Met 
        515                 520                 525             


Leu Arg Leu Leu Gly His 
    530                 


<210>  59
<211>  1569
<212>  DNA
<213>  Homo sapiens

<400>  59
atggcttcgc gctgctggcg ctggtggggc tggtcggcgt ggcctcggac ccggctgcct       60

cccgccggga gcaccccgac ctttgggggt tcagatgaag taagagaccc tgcaaatgcc      120

aaagccttga ggaacaagag aaggaggatg caggtgaggg tgaagcttgg gaagttccag      180

cttctgttgg atattcagga gaagaccccc cagatctgtg tggtgggcag tggcccagct      240

ggcttctaca cggcccaaca cctgctaaag cacccccagg cccacgtgga catctacgag      300

aaacagcctg tgccctttgg cctggtgcgc tttggtgtgg cgcctgatca ccccgaggtg      360

aagaatgtca tcaacacatt tacccagacg gcccattctg gccgctgtgc cttctggggc      420

aacgtggagg tgggcaggga cgtgacggtg ccggagctgc gggaggccta ccacgctgtg      480

gtgctgagct acggggcaga ggaccatcgg gccctggaaa ttcctggtga ggagctgcca      540

ggtgtgtgct ccgcccgggc cttcgtgggc tggtacaacg ggcttcctga gaaccaggag      600

ctggagccag acctgagctg tgacacagcc gtgattctgg ggcaggggaa cgtggctctg      660

gacgtggccc gcatcctact gaccccacct gagcacctgg agagaacgga catcacgaag      720

gcagccctgg gtgtactgag gcagagtcga gtgaagacag tgtggctagt gggccggcgt      780

ggacccctgc aagtggcctt caccattaag gagcttcggg agatgattca gttaccggga      840

gcccggccca ttttggatcc tgtggatttc ttgggtctcc aggacaagat caaggaggtc      900

ccccgcccga ggaagcggct gacggaactg ctgcttcgaa cggccacaga gaagccaggg      960

ccggcggaag ctgcccgcca ggcatcggcc tcccgtgcct ggggcctccg ctttttccga     1020

agcccccagc aggtgctgcc ctcaccagat gggcggcggg cagcaggtgt ccgcctagca     1080

gtcactagac tggagggtgt cgatgaggcc acccgtgcag tgcccacggg agacatggaa     1140

gacctccctt gtgggctggt gctcagcagc attgggtata agagccgccc tgtcgaccca     1200

agcgtgccct ttgactccaa gcttggggtc atccccaatg tggagggccg ggttatggat     1260

gtgccaggcc tctactgcag cggctgggtg aagagaggac ctacaggtgt catagccaca     1320

accatgactg acagcttcct caccggccag atgctgctgc aggacctgaa ggctgggttg     1380

ctcccctctg gccccaggcc tggctacgca gccatccagg ccctgctcag cagccgaggg     1440

gtccggccag tctctttctc agactgggag aagctggatg ccgaggaggt ggcccggggc     1500

cagggcacgg ggaagcccag ggagaagctg gtggatcctc aggagatgct gcgcctcctg     1560

ggccactga                                                             1569


<210>  60
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
1               5                   10                  15      


Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Thr Phe Gly Gly Ser Asp 
            20                  25                  30          


Glu Val Arg Asp Pro Ala Asn Ala Lys Ala Leu Arg Asn Lys Arg Arg 
        35                  40                  45              


Arg Met Gln Val Arg Val Lys Leu Gly Lys Phe Gln Leu Leu Leu Asp 
    50                  55                  60                  


Ile Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro Ala 
65                  70                  75                  80  


Gly Phe Tyr Thr Ala Gln His Leu Leu Lys His Pro Gln Ala His Val 
                85                  90                  95      


Asp Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe Gly 
            100                 105                 110         


Val Ala Pro Asp His Pro Glu Val Lys Asn Val Ile Asn Thr Phe Thr 
        115                 120                 125             


Gln Thr Ala His Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu Val 
    130                 135                 140                 


Gly Arg Asp Val Thr Val Pro Glu Leu Arg Glu Ala Tyr His Ala Val 
145                 150                 155                 160 


Val Leu Ser Tyr Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro Gly 
                165                 170                 175     


Glu Glu Leu Pro Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp Tyr 
            180                 185                 190         


Asn Gly Leu Pro Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys Asp 
        195                 200                 205             


Thr Ala Val Ile Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala Arg 
    210                 215                 220                 


Ile Leu Leu Thr Pro Pro Glu His Leu Glu Arg Thr Asp Ile Thr Lys 
225                 230                 235                 240 


Ala Ala Leu Gly Val Leu Arg Gln Ser Arg Val Lys Thr Val Trp Leu 
                245                 250                 255     


Val Gly Arg Arg Gly Pro Leu Gln Val Ala Phe Thr Ile Lys Glu Leu 
            260                 265                 270         


Arg Glu Met Ile Gln Leu Pro Gly Ala Arg Pro Ile Leu Asp Pro Val 
        275                 280                 285             


Asp Phe Leu Gly Leu Gln Asp Lys Ile Lys Glu Val Pro Arg Pro Arg 
    290                 295                 300                 


Lys Arg Leu Thr Glu Leu Leu Leu Arg Thr Ala Thr Glu Lys Pro Gly 
305                 310                 315                 320 


Pro Ala Glu Ala Ala Arg Gln Ala Ser Ala Ser Arg Ala Trp Gly Leu 
                325                 330                 335     


Arg Phe Phe Arg Ser Pro Gln Gln Val Leu Pro Ser Pro Asp Gly Arg 
            340                 345                 350         


Arg Ala Ala Gly Val Arg Leu Ala Val Thr Arg Leu Glu Gly Val Asp 
        355                 360                 365             


Glu Ala Thr Arg Ala Val Pro Thr Gly Asp Met Glu Asp Leu Pro Cys 
    370                 375                 380                 


Gly Leu Val Leu Ser Ser Ile Gly Tyr Lys Ser Arg Pro Val Asp Pro 
385                 390                 395                 400 


Ser Val Pro Phe Asp Ser Lys Leu Gly Val Ile Pro Asn Val Glu Gly 
                405                 410                 415     


Arg Val Met Asp Val Pro Gly Leu Tyr Cys Ser Gly Trp Val Lys Arg 
            420                 425                 430         


Gly Pro Thr Gly Val Ile Ala Thr Thr Met Thr Asp Ser Phe Leu Thr 
        435                 440                 445             


Gly Gln Met Leu Leu Gln Asp Leu Lys Ala Gly Leu Leu Pro Ser Gly 
    450                 455                 460                 


Pro Arg Pro Gly Tyr Ala Ala Ile Gln Ala Leu Leu Ser Ser Arg Gly 
465                 470                 475                 480 


Val Arg Pro Val Ser Phe Ser Asp Trp Glu Lys Leu Asp Ala Glu Glu 
                485                 490                 495     


Val Ala Arg Gly Gln Gly Thr Gly Lys Pro Arg Glu Lys Leu Val Asp 
            500                 505                 510         


Pro Gln Glu Met Leu Arg Leu Leu Gly His 
        515                 520         


<210>  61
<211>  1452
<212>  DNA
<213>  Homo sapiens

<400>  61
atggcttcgc gctgctggcg ctggtggggc tggtcggcgt ggcctcggac ccggctgcct       60

cccgccggga gcaccccgag cttctgccac catttctcca cacaggagaa gaccccccag      120

atctgtgtgg tgggcagtgg cccagctggc ttctacacgg cccaacacct gctaaagcac      180

ccccaggccc acgtggacat ctacgagaaa cagcctgtgc cctttggcct ggtgcgcttt      240

ggtgtggcgc ctgatcaccc cgaggtgaag acggcccatt ctggccgctg tgccttctgg      300

ggcaacgtgg aggtgggcag ggacgtgacg gtgccggagc tgcgggaggc ctaccacgct      360

gtggtgctga gctacggggc agaggaccat cgggccctgg aaattcctgg tgaggagctg      420

ccaggtgtgt gctccgcccg ggccttcgtg ggctggtaca acgggcttcc tgagaaccag      480

gagctggagc cagacctgag ctgtgacaca gccgtgattc tggggcaggg gaacgtggct      540

ctggacgtgg cccgcatcct actgacccca cctgagcacc tggagagaac ggacatcacg      600

aaggcagccc tgggtgtact gaggcagagt cgagtgaaga cagtgtggct agtgggccgg      660

cgtggacccc tgcaagtggc cttcaccatt aaggagcttc gggagatgat tcagttaccg      720

ggagcccggc ccattttgga tcctgtggat ttcttgggtc tccaggacaa gatcaaggag      780

gtcccccgcc cgaggaagcg gctgacggaa ctgctgcttc gaacggccac agagaagcca      840

gggccggcgg aagctgcccg ccaggcatcg gcctcccgtg cctggggcct ccgctttttc      900

cgaagccccc agcaggtgct gccctcacca gatgggcggc gggcagcagg tgtccgccta      960

gcagtcacta gactggaggg tgtcgatgag gccacccgtg cagtgcccac gggagacatg     1020

gaagacctcc cttgtgggct ggtgctcagc agcattgggt ataagagccg ccctgtcgac     1080

ccaagcgtgc cctttgactc caagcttggg gtcatcccca atgtggaggg ccgggttatg     1140

gatgtgccag gcctctactg cagcggctgg gtgaagagag gacctacagg tgtcatagcc     1200

acaaccatga ctgacagctt cctcaccggc cagatgctgc tgcaggacct gaaggctggg     1260

ttgctcccct ctggccccag gcctggctac gcagccatcc aggccctgct cagcagccga     1320

ggggtccggc cagtctcttt ctcagactgg gagaagctgg atgccgagga ggtggcccgg     1380

ggccagggca cggggaagcc cagggagaag ctggtggatc ctcaggagat gctgcgcctc     1440

ctgggccact ga                                                         1452


<210>  62
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
1               5                   10                  15      


Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe 
            20                  25                  30          


Ser Thr Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro 
        35                  40                  45              


Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys His Pro Gln Ala His 
    50                  55                  60                  


Val Asp Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe 
65                  70                  75                  80  


Gly Val Ala Pro Asp His Pro Glu Val Lys Thr Ala His Ser Gly Arg 
                85                  90                  95      


Cys Ala Phe Trp Gly Asn Val Glu Val Gly Arg Asp Val Thr Val Pro 
            100                 105                 110         


Glu Leu Arg Glu Ala Tyr His Ala Val Val Leu Ser Tyr Gly Ala Glu 
        115                 120                 125             


Asp His Arg Ala Leu Glu Ile Pro Gly Glu Glu Leu Pro Gly Val Cys 
    130                 135                 140                 


Ser Ala Arg Ala Phe Val Gly Trp Tyr Asn Gly Leu Pro Glu Asn Gln 
145                 150                 155                 160 


Glu Leu Glu Pro Asp Leu Ser Cys Asp Thr Ala Val Ile Leu Gly Gln 
                165                 170                 175     


Gly Asn Val Ala Leu Asp Val Ala Arg Ile Leu Leu Thr Pro Pro Glu 
            180                 185                 190         


His Leu Glu Arg Thr Asp Ile Thr Lys Ala Ala Leu Gly Val Leu Arg 
        195                 200                 205             


Gln Ser Arg Val Lys Thr Val Trp Leu Val Gly Arg Arg Gly Pro Leu 
    210                 215                 220                 


Gln Val Ala Phe Thr Ile Lys Glu Leu Arg Glu Met Ile Gln Leu Pro 
225                 230                 235                 240 


Gly Ala Arg Pro Ile Leu Asp Pro Val Asp Phe Leu Gly Leu Gln Asp 
                245                 250                 255     


Lys Ile Lys Glu Val Pro Arg Pro Arg Lys Arg Leu Thr Glu Leu Leu 
            260                 265                 270         


Leu Arg Thr Ala Thr Glu Lys Pro Gly Pro Ala Glu Ala Ala Arg Gln 
        275                 280                 285             


Ala Ser Ala Ser Arg Ala Trp Gly Leu Arg Phe Phe Arg Ser Pro Gln 
    290                 295                 300                 


Gln Val Leu Pro Ser Pro Asp Gly Arg Arg Ala Ala Gly Val Arg Leu 
305                 310                 315                 320 


Ala Val Thr Arg Leu Glu Gly Val Asp Glu Ala Thr Arg Ala Val Pro 
                325                 330                 335     


Thr Gly Asp Met Glu Asp Leu Pro Cys Gly Leu Val Leu Ser Ser Ile 
            340                 345                 350         


Gly Tyr Lys Ser Arg Pro Val Asp Pro Ser Val Pro Phe Asp Ser Lys 
        355                 360                 365             


Leu Gly Val Ile Pro Asn Val Glu Gly Arg Val Met Asp Val Pro Gly 
    370                 375                 380                 


Leu Tyr Cys Ser Gly Trp Val Lys Arg Gly Pro Thr Gly Val Ile Ala 
385                 390                 395                 400 


Thr Thr Met Thr Asp Ser Phe Leu Thr Gly Gln Met Leu Leu Gln Asp 
                405                 410                 415     


Leu Lys Ala Gly Leu Leu Pro Ser Gly Pro Arg Pro Gly Tyr Ala Ala 
            420                 425                 430         


Ile Gln Ala Leu Leu Ser Ser Arg Gly Val Arg Pro Val Ser Phe Ser 
        435                 440                 445             


Asp Trp Glu Lys Leu Asp Ala Glu Glu Val Ala Arg Gly Gln Gly Thr 
    450                 455                 460                 


Gly Lys Pro Arg Glu Lys Leu Val Asp Pro Gln Glu Met Leu Arg Leu 
465                 470                 475                 480 


Leu Gly His 
            


<210>  63
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  63
atggcttcgc gctgctggcg ctggtggggc tggtcggcgt ggcctcggac ccggctgcct       60

cccgccggga gcaccccgag cttctgccac catttctcca cacaggagaa gaccccccag      120

atctgtgtgg tgggcagtgg cccagctggc ttctacacgg cccaacacct gctaaagcag      180

cacccccagg cccacgtgga catctacgag aaacagcctg tgccctttgg cctggtgcgc      240

tttggtgtgg cgcctgatca ccccgaggtg aagagctacg gggcagagga ccatcgggcc      300

ctggaaattc ctggtgagga gctgccaggt gtgtgctccg cccgggcctt cgtgggctgg      360

tacaacgggc ttcctgagaa ccaggagctg gagccagacc tgagctgtga cacagccgtg      420

attctggggc aggggaacgt ggctctggac gtggcccgca tcctactgac cccacctgag      480

cacctggaga gaacggacat cacgaaggca gccctgggtg tactgaggca gagtcgagtg      540

aagacagtgt ggctagtggg ccggcgtgga cccctgcaag tggccttcac cattaaggag      600

cttcgggaga tgattcagtt accgggagcc cggcccattt tggatcctgt ggatttcttg      660

ggtctccagg acaagatcaa ggaggtcccc cgcccgagga agcggctgac ggaactgctg      720

cttcgaacgg ccacagagaa gccagggccg gcggaagctg cccgccaggc atcggcctcc      780

cgtgcctggg gcctccgctt tttccgaagc ccccagcagg tgctgccctc accagatggg      840

cggcgggcag caggtgtccg cctagcagtc actagactgg agggtgtcga tgaggccacc      900

cgtgcagtgc ccacgggaga catggaagac ctcccttgtg ggctggtgct cagcagcatt      960

gggtataaga gccgccctgt cgacccaagc gtgccctttg actccaagct tggggtcatc     1020

cccaatgtgg agggccgggt tatggatgtg ccaggcctct actgcagcgg ctgggtgaag     1080

agaggaccta caggtgtcat agccacaacc atgactgaca gcttcctcac cggccagatg     1140

ctgctgcagg acctgaaggc tgggttgctc ccctctggcc ccaggcctgg ctacgcagcc     1200

atccaggccc tgctcagcag ccgaggggtc cggccagtct ctttctcaga ctgggagaag     1260

ctggatgccg aggaggtggc ccggggccag ggcacgggga agcccaggga gaagctggtg     1320

gatcctcagg agatgctgcg cctcctgggc cactga                               1356


<210>  64
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
1               5                   10                  15      


Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe 
            20                  25                  30          


Ser Thr Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro 
        35                  40                  45              


Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys Gln His Pro Gln Ala 
    50                  55                  60                  


His Val Asp Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg 
65                  70                  75                  80  


Phe Gly Val Ala Pro Asp His Pro Glu Val Lys Ser Tyr Gly Ala Glu 
                85                  90                  95      


Asp His Arg Ala Leu Glu Ile Pro Gly Glu Glu Leu Pro Gly Val Cys 
            100                 105                 110         


Ser Ala Arg Ala Phe Val Gly Trp Tyr Asn Gly Leu Pro Glu Asn Gln 
        115                 120                 125             


Glu Leu Glu Pro Asp Leu Ser Cys Asp Thr Ala Val Ile Leu Gly Gln 
    130                 135                 140                 


Gly Asn Val Ala Leu Asp Val Ala Arg Ile Leu Leu Thr Pro Pro Glu 
145                 150                 155                 160 


His Leu Glu Arg Thr Asp Ile Thr Lys Ala Ala Leu Gly Val Leu Arg 
                165                 170                 175     


Gln Ser Arg Val Lys Thr Val Trp Leu Val Gly Arg Arg Gly Pro Leu 
            180                 185                 190         


Gln Val Ala Phe Thr Ile Lys Glu Leu Arg Glu Met Ile Gln Leu Pro 
        195                 200                 205             


Gly Ala Arg Pro Ile Leu Asp Pro Val Asp Phe Leu Gly Leu Gln Asp 
    210                 215                 220                 


Lys Ile Lys Glu Val Pro Arg Pro Arg Lys Arg Leu Thr Glu Leu Leu 
225                 230                 235                 240 


Leu Arg Thr Ala Thr Glu Lys Pro Gly Pro Ala Glu Ala Ala Arg Gln 
                245                 250                 255     


Ala Ser Ala Ser Arg Ala Trp Gly Leu Arg Phe Phe Arg Ser Pro Gln 
            260                 265                 270         


Gln Val Leu Pro Ser Pro Asp Gly Arg Arg Ala Ala Gly Val Arg Leu 
        275                 280                 285             


Ala Val Thr Arg Leu Glu Gly Val Asp Glu Ala Thr Arg Ala Val Pro 
    290                 295                 300                 


Thr Gly Asp Met Glu Asp Leu Pro Cys Gly Leu Val Leu Ser Ser Ile 
305                 310                 315                 320 


Gly Tyr Lys Ser Arg Pro Val Asp Pro Ser Val Pro Phe Asp Ser Lys 
                325                 330                 335     


Leu Gly Val Ile Pro Asn Val Glu Gly Arg Val Met Asp Val Pro Gly 
            340                 345                 350         


Leu Tyr Cys Ser Gly Trp Val Lys Arg Gly Pro Thr Gly Val Ile Ala 
        355                 360                 365             


Thr Thr Met Thr Asp Ser Phe Leu Thr Gly Gln Met Leu Leu Gln Asp 
    370                 375                 380                 


Leu Lys Ala Gly Leu Leu Pro Ser Gly Pro Arg Pro Gly Tyr Ala Ala 
385                 390                 395                 400 


Ile Gln Ala Leu Leu Ser Ser Arg Gly Val Arg Pro Val Ser Phe Ser 
                405                 410                 415     


Asp Trp Glu Lys Leu Asp Ala Glu Glu Val Ala Arg Gly Gln Gly Thr 
            420                 425                 430         


Gly Lys Pro Arg Glu Lys Leu Val Asp Pro Gln Glu Met Leu Arg Leu 
        435                 440                 445             


Leu Gly His 
    450     


<210>  65
<211>  1320
<212>  DNA
<213>  Homo sapiens

<400>  65
atggaagata aggacagaga gcacccccag gcccacgtgg acatctacga gaaacagcct       60

gtgccctttg gcctggtgcg ctttggtgtg gcgcctgatc accccgaggt gaagaatgtc      120

atcaacacat ttacccagac ggcccattct ggccgctgtg ccttctgggg caacgtggag      180

gtgggcaggg acgtgacggt gccggagctg cgggaggcct accacgctgt ggtgctgagc      240

tacggggcag aggaccatcg ggccctggaa attcctggtg aggagctgcc aggtgtgtgc      300

tccgcccggg ccttcgtggg ctggtacaac gggcttcctg agaaccagga gctggagcca      360

gacctgagct gtgacacagc cgtgattctg gggcagggga acgtggctct ggacgtggcc      420

cgcatcctac tgaccccacc tgagcacctg gagagaacgg acatcacgaa ggcagccctg      480

ggtgtactga ggcagagtcg agtgaagaca gtgtggctag tgggccggcg tggacccctg      540

caagtggcct tcaccattaa ggagcttcgg gagatgattc agttaccggg agcccggccc      600

attttggatc ctgtggattt cttgggtctc caggacaaga tcaaggaggt cccccgcccg      660

aggaagcggc tgacggaact gctgcttcga acggccacag agaagccagg gccggcggaa      720

gctgcccgcc aggcatcggc ctcccgtgcc tggggcctcc gctttttccg aagcccccag      780

caggtgctgc cctcaccaga tgggcggcgg gcagcaggtg tccgcctagc agtcactaga      840

ctggagggtg tcgatgaggc cacccgtgca gtgcccacgg gagacatgga agacctccct      900

tgtgggctgg tgctcagcag cattgggtat aagagccgcc ctgtcgaccc aagcgtgccc      960

tttgactcca agcttggggt catccccaat gtggagggcc gggttatgga tgtgccaggc     1020

ctctactgca gcggctgggt gaagagagga cctacaggtg tcatagccac aaccatgact     1080

gacagcttcc tcaccggcca gatgctgctg caggacctga aggctgggtt gctcccctct     1140

ggccccaggc ctggctacgc agccatccag gccctgctca gcagccgagg ggtccggcca     1200

gtctctttct cagactggga gaagctggat gccgaggagg tggcccgggg ccagggcacg     1260

gggaagccca gggagaagct ggtggatcct caggagatgc tgcgcctcct gggccactga     1320


<210>  66
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Glu Asp Lys Asp Arg Glu His Pro Gln Ala His Val Asp Ile Tyr 
1               5                   10                  15      


Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe Gly Val Ala Pro 
            20                  25                  30          


Asp His Pro Glu Val Lys Asn Val Ile Asn Thr Phe Thr Gln Thr Ala 
        35                  40                  45              


His Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu Val Gly Arg Asp 
    50                  55                  60                  


Val Thr Val Pro Glu Leu Arg Glu Ala Tyr His Ala Val Val Leu Ser 
65                  70                  75                  80  


Tyr Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro Gly Glu Glu Leu 
                85                  90                  95      


Pro Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp Tyr Asn Gly Leu 
            100                 105                 110         


Pro Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys Asp Thr Ala Val 
        115                 120                 125             


Ile Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala Arg Ile Leu Leu 
    130                 135                 140                 


Thr Pro Pro Glu His Leu Glu Arg Thr Asp Ile Thr Lys Ala Ala Leu 
145                 150                 155                 160 


Gly Val Leu Arg Gln Ser Arg Val Lys Thr Val Trp Leu Val Gly Arg 
                165                 170                 175     


Arg Gly Pro Leu Gln Val Ala Phe Thr Ile Lys Glu Leu Arg Glu Met 
            180                 185                 190         


Ile Gln Leu Pro Gly Ala Arg Pro Ile Leu Asp Pro Val Asp Phe Leu 
        195                 200                 205             


Gly Leu Gln Asp Lys Ile Lys Glu Val Pro Arg Pro Arg Lys Arg Leu 
    210                 215                 220                 


Thr Glu Leu Leu Leu Arg Thr Ala Thr Glu Lys Pro Gly Pro Ala Glu 
225                 230                 235                 240 


Ala Ala Arg Gln Ala Ser Ala Ser Arg Ala Trp Gly Leu Arg Phe Phe 
                245                 250                 255     


Arg Ser Pro Gln Gln Val Leu Pro Ser Pro Asp Gly Arg Arg Ala Ala 
            260                 265                 270         


Gly Val Arg Leu Ala Val Thr Arg Leu Glu Gly Val Asp Glu Ala Thr 
        275                 280                 285             


Arg Ala Val Pro Thr Gly Asp Met Glu Asp Leu Pro Cys Gly Leu Val 
    290                 295                 300                 


Leu Ser Ser Ile Gly Tyr Lys Ser Arg Pro Val Asp Pro Ser Val Pro 
305                 310                 315                 320 


Phe Asp Ser Lys Leu Gly Val Ile Pro Asn Val Glu Gly Arg Val Met 
                325                 330                 335     


Asp Val Pro Gly Leu Tyr Cys Ser Gly Trp Val Lys Arg Gly Pro Thr 
            340                 345                 350         


Gly Val Ile Ala Thr Thr Met Thr Asp Ser Phe Leu Thr Gly Gln Met 
        355                 360                 365             


Leu Leu Gln Asp Leu Lys Ala Gly Leu Leu Pro Ser Gly Pro Arg Pro 
    370                 375                 380                 


Gly Tyr Ala Ala Ile Gln Ala Leu Leu Ser Ser Arg Gly Val Arg Pro 
385                 390                 395                 400 


Val Ser Phe Ser Asp Trp Glu Lys Leu Asp Ala Glu Glu Val Ala Arg 
                405                 410                 415     


Gly Gln Gly Thr Gly Lys Pro Arg Glu Lys Leu Val Asp Pro Gln Glu 
            420                 425                 430         


Met Leu Arg Leu Leu Gly His 
        435                 


<210>  67
<211>  552
<212>  DNA
<213>  Homo sapiens

<400>  67
atggccgcct ccatggcccg gggaggcgtg agtgccaggg ttctactgca ggctgccagg       60

ggcacctggt ggaacagacc tgggggcact tccgggtcgg gggagggggt ggcgctgggg      120

acaaccagaa agtttcaagc gacaggctcg cgcccggctg gagaggagga cgcgggcggc      180

ccggagcggc ccggggacgt ggtgaacgtg gtgttcgtag accgctcagg ccagcggatc      240

ccagtgagtg gcagagtcgg ggacaatgtt cttcacctgg cccagcgcca cggggtggac      300

ctggaagggg cctgtgaagc ctccctggcc tgctccacct gccatgtgta tgtgagtgaa      360

gaccacctgg atctcctgcc tcctcccgag gagagggaag acgacatgct agacatggcc      420

cccctcctcc aggagaactc gcggctgggc tgccagattg tgctgacacc ggagctggaa      480

ggagcggaat tcaccctgcc caagatcacc aggaacttct acgtggatgg ccatgtcccc      540

aagccccact ga                                                          552


<210>  68
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ala Ala Ser Met Ala Arg Gly Gly Val Ser Ala Arg Val Leu Leu 
1               5                   10                  15      


Gln Ala Ala Arg Gly Thr Trp Trp Asn Arg Pro Gly Gly Thr Ser Gly 
            20                  25                  30          


Ser Gly Glu Gly Val Ala Leu Gly Thr Thr Arg Lys Phe Gln Ala Thr 
        35                  40                  45              


Gly Ser Arg Pro Ala Gly Glu Glu Asp Ala Gly Gly Pro Glu Arg Pro 
    50                  55                  60                  


Gly Asp Val Val Asn Val Val Phe Val Asp Arg Ser Gly Gln Arg Ile 
65                  70                  75                  80  


Pro Val Ser Gly Arg Val Gly Asp Asn Val Leu His Leu Ala Gln Arg 
                85                  90                  95      


His Gly Val Asp Leu Glu Gly Ala Cys Glu Ala Ser Leu Ala Cys Ser 
            100                 105                 110         


Thr Cys His Val Tyr Val Ser Glu Asp His Leu Asp Leu Leu Pro Pro 
        115                 120                 125             


Pro Glu Glu Arg Glu Asp Asp Met Leu Asp Met Ala Pro Leu Leu Gln 
    130                 135                 140                 


Glu Asn Ser Arg Leu Gly Cys Gln Ile Val Leu Thr Pro Glu Leu Glu 
145                 150                 155                 160 


Gly Ala Glu Phe Thr Leu Pro Lys Ile Thr Arg Asn Phe Tyr Val Asp 
                165                 170                 175     


Gly His Val Pro Lys Pro His 
            180             


<210>  69
<211>  2670
<212>  DNA
<213>  Homo sapiens

<400>  69
atgagcaacc cattcgcaca ccttgctgag ccattggatc ctgtacaacc aggaaagaaa       60

ttcttcaatt tgaataaatt ggaggattca agatatgggc gcttaccatt ttcgatcaga      120

gttcttctgg aagcagccat tcggaattgt gatgagtttt tggtgaagaa acaggatatt      180

gaaaatattc tacattggaa tgtcacgcag cacaagaaca tagaagtgcc atttaagcct      240

gctcgtgtca tcctgcagga ctttacgggt gtgcccgctg tggttgactt tgctgcaatg      300

cgtgatgctg tgaaaaagtt aggaggagat ccagagaaaa taaaccctgt ctgccctgct      360

gatcttgtaa tagatcattc catccaggtt gatttcaaca gaagggcaga cagtttacag      420

aagaatcaag acctggaatt tgaaagaaat agagagcgat ttgaattttt aaagtggggt      480

tcccaggctt ttcacaacat gcggattatt ccccctggct caggaatcat ccaccaggtg      540

aatttggaat atttggcaag agtggtattt gatcaggatg gatattatta cccagacagc      600

ctcgtgggca cagactcgca cactaccatg attgatggct tgggcattct tggttggggt      660

gtcggtggta ttgaagcaga agctgtcatg ctgggtcagc caatcagtat ggtgcttcct      720

caggtgattg gctacaggct gatggggaag ccccaccctc tggtaacatc cactgacatc      780

gtgctcacca ttaccaagca cctccgccag gttggggtag tgggcaaatt tgtcgagttc      840

ttcgggcctg gagtagccca gttgtccatt gctgaccgag ctacgattgc taacatgtgt      900

ccagagtacg gagcaactgc tgcctttttc ccagttgatg aagttagtat cacgtacctg      960

gtgcaaacag gtcgtgatga agaaaaatta aagtatatta aaaaatatct tcaggctgta     1020

ggaatgtttc gagatttcaa tgacccttct caagacccag acttcaccca ggttgtggaa     1080

ttagatttga aaacagtagt gccttgctgt agtggaccca aaaggcctca ggacaaagtt     1140

gctgtgtccg acatgaaaaa ggactttgag agctgccttg gagccaagca aggatttaaa     1200

ggattccaag ttgctcctga acatcataat gaccataaga cctttatcta tgataacact     1260

gaattcaccc ttgctcatgg ttctgtggtc attgctgcca ttactagctg cacaaacacc     1320

agtaatccgt ctgtgatgtt aggggcagga ttgttagcaa agaaagctgt ggatgctggc     1380

ctgaacgtga tgccttacat caaaactagc ctgtctcctg ggagtggcgt ggtcacctac     1440

tacctacaag aaagcggagt catgccttat ctgtctcagc ttgggtttga cgtggtgggc     1500

tatggctgca tgacctgcat tggcaacagt gggcctttac ctgaacctgt ggtagaagcc     1560

atcacacagg gagaccttgt agctgttgga gtactatctg gaaacaggaa ttttgaaggt     1620

cgagttcacc ccaacacccg ggccaactat ttagcctctc cccccttagt aatagcatat     1680

gcaattgctg gaaccatcag aatcgacttt gagaaagagc cattgggagt aaatgcaaag     1740

ggacagcagg tatttctgaa agatatctgg ccgactagag acgagatcca ggcagtggag     1800

cgtcagtatg tcatcccggg gatgtttaag gaagtctatc agaaaataga gactgtgaat     1860

gaaagctgga atgccttagc aaccccatca gataagctgt ttttctggaa ttccaaatct     1920

acgtatatca aatcaccacc attctttgaa aacctgactt tggatcttca gccccctaaa     1980

tctatagtgg atgcctatgt gctgctaaat ttgggagatt cggtaacaac tgaccacatc     2040

tccccagctg gaaatattgc aagaaacagt cctgctgctc gctacttaac taacagaggc     2100

ctaactccac gagaattcaa ctcctatggc tcccgccgag gtaatgacgc cgtcatggca     2160

cggggaacat ttgccaacat tcgcttgtta aacagatttt tgaacaagca ggcaccacag     2220

actatccatc tgccttctgg ggaaatcctt gatgtgtttg atgctgctga gcggtaccag     2280

caggcaggcc ttcccctgat cgttctggct ggcaaagagt acggtgcagg cagctcccga     2340

gactgggcag ctaagggccc tttcctgctg ggaatcaaag ccgtcctggc cgagagctac     2400

gagcgcattc accgcagtaa cctggttggg atgggtgtga tcccacttga atatctccct     2460

ggtgagaatg cagatgccct ggggctcaca gggcaagaac gatacactat cattattcca     2520

gaaaacctca aaccacaaat gaaagtccag gtcaagctgg atactggcaa gaccttccag     2580

gctgtcatga ggtttgacac tgatgtggag ctcacttatt tcctcaacgg gggcatcctc     2640

aactacatga tccgcaagat ggccaagtag                                      2670


<210>  70
<211>  2670
<212>  DNA
<213>  Homo sapiens

<400>  70
atgagcaacc cattcgcaca ccttgctgag ccattggatc ctgtacaacc aggaaagaaa       60

ttcttcaatt tgaataaatt ggaggattca agatatgggc gcttaccatt ttcgatcaga      120

gttcttctgg aagcagccat tcggaattgt gatgagtttt tggtgaagaa acaggatatt      180

gaaaatattc tacattggaa tgtcacgcag cacaagaaca tagaagtgcc atttaagcct      240

gctcgtgtca tcctgcagga ctttacgggt gtgcccgctg tggttgactt tgctgcaatg      300

cgtgatgctg tgaaaaagtt aggaggagat ccagagaaaa taaaccctgt ctgccctgct      360

gatcttgtaa tagatcattc catccaggtt gatttcaaca gaagggcaga cagtttacag      420

aagaatcaag acctggaatt tgaaagaaat agagagcgat ttgaattttt aaagtggggt      480

tcccaggctt ttcacaacat gcggattatt ccccctggct caggaatcat ccaccaggtg      540

aatttggaat atttggcaag agtggtattt gatcaggatg gatattatta cccagacagc      600

ctcgtgggca cagactcgca cactaccatg attgatggct tgggcattct tggttggggt      660

gtcggtggta ttgaagcaga agctgtcatg ctgggtcagc caatcagtat ggtgcttcct      720

caggtgattg gctacaggct gatggggaag ccccaccctc tggtaacatc cactgacatc      780

gtgctcacca ttaccaagca cctccgccag gttggggtag tgggcaaatt tgtcgagttc      840

ttcgggcctg gagtagccca gttgtccatt gctgaccgag ctacgattgc taacatgtgt      900

ccagagtacg gagcaactgc tgcctttttc ccagttgatg aagttagtat cacgtacctg      960

gtgcaaacag gtcgtgatga agaaaaatta aagtatatta aaaaatatct tcaggctgta     1020

ggaatgtttc gagatttcaa tgacccttct caagacccag acttcaccca ggttgtggaa     1080

ttagatttga aaacagtagt gccttgctgt agtggaccca aaaggcctca ggacaaagtt     1140

gctgtgtccg acatgaaaaa ggactttgag agctgccttg gagccaagca aggatttaaa     1200

ggattccaag ttgctcctga acatcataat gaccataaga cctttatcta tgataacact     1260

gaattcaccc ttgctcatgg ttctgtggtc attgctgcca ttactagctg cacaaacacc     1320

agtaatccgt ctgtgatgtt aggggcagga ttgttagcaa agaaagctgt ggatgctggc     1380

ctgaacgtga tgccttacat caaaactagc ctgtctcctg ggagtggcgt ggtcacctac     1440

tacctacaag aaagcggagt catgccttat ctgtctcagc ttgggtttga cgtggtgggc     1500

tatggctgca tgacctgcat tggcaacagt gggcctttac ctgaacctgt ggtagaagcc     1560

atcacacagg gagaccttgt agctgttgga gtactatctg gaaacaggaa ttttgaaggt     1620

cgagttcacc ccaacacccg ggccaactat ttagcctctc cccccttagt aatagcatat     1680

gcaattgctg gaaccatcag aatcgacttt gagaaagagc cattgggagt aaatgcaaag     1740

ggacagcagg tatttctgaa agatatctgg ccgactagag acgagatcca ggcagtggag     1800

cgtcagtatg tcatcccggg gatgtttaag gaagtctatc agaaaataga gactgtgaat     1860

gaaagctgga atgccttagc aaccccatca gataagctgt ttttctggaa ttccaaatct     1920

acgtatatca aatcaccacc attctttgaa aacctgactt tggatcttca gccccctaaa     1980

tctatagtgg atgcctatgt gctgctaaat ttgggagatt cggtaacaac tgaccacatc     2040

tccccagctg gaaatattgc aagaaacagt cctgctgctc gctacttaac taacagaggc     2100

ctaactccac gagaattcaa ctcctatggc tcccgccgag gtaatgacgc cgtcatggca     2160

cggggaacat ttgccaacat tcgcttgtta aacagatttt tgaacaagca ggcaccacag     2220

actatccatc tgccttctgg ggaaatcctt gatgtgtttg atgctgctga gcggtaccag     2280

caggcaggcc ttcccctgat cgttctggct ggcaaagagt acggtgcagg cagctcccga     2340

gactgggcag ctaagggccc tttcctgctg ggaatcaaag ccgtcctggc cgagagctac     2400

gagcgcattc accgcagtaa cctggttggg atgggtgtga tcccacttga atatctccct     2460

ggtgagaatg cagatgccct ggggctcaca gggcaagaac gatacactat cattattcca     2520

gaaaacctca aaccacaaat gaaagtccag gtcaagctgg atactggcaa gaccttccag     2580

gctgtcatga ggtttgacac tgatgtggag ctcacttatt tcctcaacgg gggcatcctc     2640

aactacatga tccgcaagat ggccaagtag                                      2670


<210>  71
<211>  889
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ser Asn Pro Phe Ala His Leu Ala Glu Pro Leu Asp Pro Val Gln 
1               5                   10                  15      


Pro Gly Lys Lys Phe Phe Asn Leu Asn Lys Leu Glu Asp Ser Arg Tyr 
            20                  25                  30          


Gly Arg Leu Pro Phe Ser Ile Arg Val Leu Leu Glu Ala Ala Ile Arg 
        35                  40                  45              


Asn Cys Asp Glu Phe Leu Val Lys Lys Gln Asp Ile Glu Asn Ile Leu 
    50                  55                  60                  


His Trp Asn Val Thr Gln His Lys Asn Ile Glu Val Pro Phe Lys Pro 
65                  70                  75                  80  


Ala Arg Val Ile Leu Gln Asp Phe Thr Gly Val Pro Ala Val Val Asp 
                85                  90                  95      


Phe Ala Ala Met Arg Asp Ala Val Lys Lys Leu Gly Gly Asp Pro Glu 
            100                 105                 110         


Lys Ile Asn Pro Val Cys Pro Ala Asp Leu Val Ile Asp His Ser Ile 
        115                 120                 125             


Gln Val Asp Phe Asn Arg Arg Ala Asp Ser Leu Gln Lys Asn Gln Asp 
    130                 135                 140                 


Leu Glu Phe Glu Arg Asn Arg Glu Arg Phe Glu Phe Leu Lys Trp Gly 
145                 150                 155                 160 


Ser Gln Ala Phe His Asn Met Arg Ile Ile Pro Pro Gly Ser Gly Ile 
                165                 170                 175     


Ile His Gln Val Asn Leu Glu Tyr Leu Ala Arg Val Val Phe Asp Gln 
            180                 185                 190         


Asp Gly Tyr Tyr Tyr Pro Asp Ser Leu Val Gly Thr Asp Ser His Thr 
        195                 200                 205             


Thr Met Ile Asp Gly Leu Gly Ile Leu Gly Trp Gly Val Gly Gly Ile 
    210                 215                 220                 


Glu Ala Glu Ala Val Met Leu Gly Gln Pro Ile Ser Met Val Leu Pro 
225                 230                 235                 240 


Gln Val Ile Gly Tyr Arg Leu Met Gly Lys Pro His Pro Leu Val Thr 
                245                 250                 255     


Ser Thr Asp Ile Val Leu Thr Ile Thr Lys His Leu Arg Gln Val Gly 
            260                 265                 270         


Val Val Gly Lys Phe Val Glu Phe Phe Gly Pro Gly Val Ala Gln Leu 
        275                 280                 285             


Ser Ile Ala Asp Arg Ala Thr Ile Ala Asn Met Cys Pro Glu Tyr Gly 
    290                 295                 300                 


Ala Thr Ala Ala Phe Phe Pro Val Asp Glu Val Ser Ile Thr Tyr Leu 
305                 310                 315                 320 


Val Gln Thr Gly Arg Asp Glu Glu Lys Leu Lys Tyr Ile Lys Lys Tyr 
                325                 330                 335     


Leu Gln Ala Val Gly Met Phe Arg Asp Phe Asn Asp Pro Ser Gln Asp 
            340                 345                 350         


Pro Asp Phe Thr Gln Val Val Glu Leu Asp Leu Lys Thr Val Val Pro 
        355                 360                 365             


Cys Cys Ser Gly Pro Lys Arg Pro Gln Asp Lys Val Ala Val Ser Asp 
    370                 375                 380                 


Met Lys Lys Asp Phe Glu Ser Cys Leu Gly Ala Lys Gln Gly Phe Lys 
385                 390                 395                 400 


Gly Phe Gln Val Ala Pro Glu His His Asn Asp His Lys Thr Phe Ile 
                405                 410                 415     


Tyr Asp Asn Thr Glu Phe Thr Leu Ala His Gly Ser Val Val Ile Ala 
            420                 425                 430         


Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro Ser Val Met Leu Gly 
        435                 440                 445             


Ala Gly Leu Leu Ala Lys Lys Ala Val Asp Ala Gly Leu Asn Val Met 
    450                 455                 460                 


Pro Tyr Ile Lys Thr Ser Leu Ser Pro Gly Ser Gly Val Val Thr Tyr 
465                 470                 475                 480 


Tyr Leu Gln Glu Ser Gly Val Met Pro Tyr Leu Ser Gln Leu Gly Phe 
                485                 490                 495     


Asp Val Val Gly Tyr Gly Cys Met Thr Cys Ile Gly Asn Ser Gly Pro 
            500                 505                 510         


Leu Pro Glu Pro Val Val Glu Ala Ile Thr Gln Gly Asp Leu Val Ala 
        515                 520                 525             


Val Gly Val Leu Ser Gly Asn Arg Asn Phe Glu Gly Arg Val His Pro 
    530                 535                 540                 


Asn Thr Arg Ala Asn Tyr Leu Ala Ser Pro Pro Leu Val Ile Ala Tyr 
545                 550                 555                 560 


Ala Ile Ala Gly Thr Ile Arg Ile Asp Phe Glu Lys Glu Pro Leu Gly 
                565                 570                 575     


Val Asn Ala Lys Gly Gln Gln Val Phe Leu Lys Asp Ile Trp Pro Thr 
            580                 585                 590         


Arg Asp Glu Ile Gln Ala Val Glu Arg Gln Tyr Val Ile Pro Gly Met 
        595                 600                 605             


Phe Lys Glu Val Tyr Gln Lys Ile Glu Thr Val Asn Glu Ser Trp Asn 
    610                 615                 620                 


Ala Leu Ala Thr Pro Ser Asp Lys Leu Phe Phe Trp Asn Ser Lys Ser 
625                 630                 635                 640 


Thr Tyr Ile Lys Ser Pro Pro Phe Phe Glu Asn Leu Thr Leu Asp Leu 
                645                 650                 655     


Gln Pro Pro Lys Ser Ile Val Asp Ala Tyr Val Leu Leu Asn Leu Gly 
            660                 665                 670         


Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala Gly Asn Ile Ala Arg 
        675                 680                 685             


Asn Ser Pro Ala Ala Arg Tyr Leu Thr Asn Arg Gly Leu Thr Pro Arg 
    690                 695                 700                 


Glu Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn Asp Ala Val Met Ala 
705                 710                 715                 720 


Arg Gly Thr Phe Ala Asn Ile Arg Leu Leu Asn Arg Phe Leu Asn Lys 
                725                 730                 735     


Gln Ala Pro Gln Thr Ile His Leu Pro Ser Gly Glu Ile Leu Asp Val 
            740                 745                 750         


Phe Asp Ala Ala Glu Arg Tyr Gln Gln Ala Gly Leu Pro Leu Ile Val 
        755                 760                 765             


Leu Ala Gly Lys Glu Tyr Gly Ala Gly Ser Ser Arg Asp Trp Ala Ala 
    770                 775                 780                 


Lys Gly Pro Phe Leu Leu Gly Ile Lys Ala Val Leu Ala Glu Ser Tyr 
785                 790                 795                 800 


Glu Arg Ile His Arg Ser Asn Leu Val Gly Met Gly Val Ile Pro Leu 
                805                 810                 815     


Glu Tyr Leu Pro Gly Glu Asn Ala Asp Ala Leu Gly Leu Thr Gly Gln 
            820                 825                 830         


Glu Arg Tyr Thr Ile Ile Ile Pro Glu Asn Leu Lys Pro Gln Met Lys 
        835                 840                 845             


Val Gln Val Lys Leu Asp Thr Gly Lys Thr Phe Gln Ala Val Met Arg 
    850                 855                 860                 


Phe Asp Thr Asp Val Glu Leu Thr Tyr Phe Leu Asn Gly Gly Ile Leu 
865                 870                 875                 880 


Asn Tyr Met Ile Arg Lys Met Ala Lys 
                885                 


<210>  72
<211>  2343
<212>  DNA
<213>  Homo sapiens

<400>  72
atggcgccct acagcctact ggtgactcgg ctgcagaaag ctctgggtgt gcggcagtac       60

catgtggcct cagtcctgtg ccaacgggcc aaggtggcga tgagccactt tgagcccaac      120

gagtacatcc attatgacct gctagagaag aacattaaca ttgttcgcaa acgactgaac      180

cggccgctga cactctcgga gaagattgtg tatggacacc tggatgaccc cgccagccag      240

gaaattgagc gaggcaagtc gtacctgcgg ctgcggccgg accgtgtggc catgcaggat      300

gcgacggccc agatggccat gctccagttc atcagcagcg ggctgtccaa ggtggctgtg      360

ccatccacca tccactgtga ccatctgatt gaagcccagg ttgggggcga gaaagacctg      420

cgccgggcca aggacatcaa ccaggaagtt tataatttcc tggcaactgc aggtgccaaa      480

tatggcgtgg gcttctggaa gcctggatct ggaatcattc accagattat tctggaaaac      540

tatgcgtacc ctggtgttct tctgattggc actgactccc acacccccaa tggtggcggc      600

cttgggggca tctgcattgg agttgggggt gccgatgctg tggatgtcat ggctgggatc      660

ccctgggagc tgaagtgccc caaggtgatt ggcgtgaagc tgacgggctc tctctccggt      720

tggtcctcac ccaaagatgt gatcctgaag gtggcaggca tcctcacggt gaaaggtggc      780

acaggtgcaa tcgtggaata ccacgggcct ggtgtagact ccatctcctg cactggcatg      840

gcgacaatct gcaacatggg tgcagaaatt ggggccacca cttccgtgtt cccttacaac      900

cacaggatga agaagtacct gagcaagacc ggccgggaag acattgccaa tctagctgat      960

gaattcaagg atcacttggt gcctgaccct ggctgccatt atgaccaact aattgaaatt     1020

aacctcagtg agctgaagcc acacatcaat gggcccttca cccctgacct ggctcaccct     1080

gtggcagaag tgggcaaggt ggcagagaag gaaggatggc ctctggacat ccgagtgggt     1140

ctaattggta gctgcaccaa ttcaagctat gaagatatgg ggcgctcagc agctgtggcc     1200

aagcaggcac tggcccatgg cctcaagtgc aagtcccagt tcaccatcac tccaggttcc     1260

gagcagatcc gcgccaccat tgagcgggac ggctatgcac agatcttgag ggatctgggt     1320

ggcattgtcc tggccaatgc ttgtggcccc tgcattggcc agtgggacag gaaggacatc     1380

aagaaggggg agaagaacac aatcgtcacc tcctacaaca ggaacttcac gggccgcaac     1440

gacgcaaacc ccgagaccca tgcctttgtc acgtccccag agattgtcac agccctggcc     1500

attgcgggaa ccctcaagtt caacccagag accgactacc tgacgggcac ggatggcaag     1560

aagttcaggc tggaggctcc ggatgcagat gagcttccca aaggggagtt tgacccaggg     1620

caggacacct accagcaccc acccaaggac agcagcgggc agcatgtgga cgtgagcccc     1680

accagccagc gcctgcagct cctggagcct tttgacaagt gggatggcaa ggacctggag     1740

gacctgcaga tcctcatcaa ggtcaaaggg aagtgtacca ctgaccacat ctcagctgct     1800

ggcccctggc tcaagttccg tgggcacttg gataacatct ccaacaacct gctcattggt     1860

gccatcaaca ttgaaaacgg caaggccaac tccgtgcgca atgccgtcac tcaggagttt     1920

ggccccgtcc ctgacactgc ccgctactac aagaaacatg gcatcaggtg ggtggtgatc     1980

ggagacgaga actacggcga gggctcgagc cgggagcatg cagctctgga gcctcgccac     2040

cttgggggcc gggccatcat caccaagagc tttgccagga tccacgagac caacctgaag     2100

aaacagggcc tgctgcctct gaccttcgct gacccggctg actacaacaa gattcaccct     2160

gtggacaagc tgaccattca gggcctgaag gacttcaccc ctggcaagcc cctgaagtgc     2220

atcatcaagc accccaacgg gacccaggag accatcctcc tgaaccacac cttcaacgag     2280

acgcagattg agtggttccg cgctggcagt gccctcaaca gaatgaagga actgcaacag     2340

tga                                                                   2343


<210>  73
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ala Pro Tyr Ser Leu Leu Val Thr Arg Leu Gln Lys Ala Leu Gly 
1               5                   10                  15      


Val Arg Gln Tyr His Val Ala Ser Val Leu Cys Gln Arg Ala Lys Val 
            20                  25                  30          


Ala Met Ser His Phe Glu Pro Asn Glu Tyr Ile His Tyr Asp Leu Leu 
        35                  40                  45              


Glu Lys Asn Ile Asn Ile Val Arg Lys Arg Leu Asn Arg Pro Leu Thr 
    50                  55                  60                  


Leu Ser Glu Lys Ile Val Tyr Gly His Leu Asp Asp Pro Ala Ser Gln 
65                  70                  75                  80  


Glu Ile Glu Arg Gly Lys Ser Tyr Leu Arg Leu Arg Pro Asp Arg Val 
                85                  90                  95      


Ala Met Gln Asp Ala Thr Ala Gln Met Ala Met Leu Gln Phe Ile Ser 
            100                 105                 110         


Ser Gly Leu Ser Lys Val Ala Val Pro Ser Thr Ile His Cys Asp His 
        115                 120                 125             


Leu Ile Glu Ala Gln Val Gly Gly Glu Lys Asp Leu Arg Arg Ala Lys 
    130                 135                 140                 


Asp Ile Asn Gln Glu Val Tyr Asn Phe Leu Ala Thr Ala Gly Ala Lys 
145                 150                 155                 160 


Tyr Gly Val Gly Phe Trp Lys Pro Gly Ser Gly Ile Ile His Gln Ile 
                165                 170                 175     


Ile Leu Glu Asn Tyr Ala Tyr Pro Gly Val Leu Leu Ile Gly Thr Asp 
            180                 185                 190         


Ser His Thr Pro Asn Gly Gly Gly Leu Gly Gly Ile Cys Ile Gly Val 
        195                 200                 205             


Gly Gly Ala Asp Ala Val Asp Val Met Ala Gly Ile Pro Trp Glu Leu 
    210                 215                 220                 


Lys Cys Pro Lys Val Ile Gly Val Lys Leu Thr Gly Ser Leu Ser Gly 
225                 230                 235                 240 


Trp Ser Ser Pro Lys Asp Val Ile Leu Lys Val Ala Gly Ile Leu Thr 
                245                 250                 255     


Val Lys Gly Gly Thr Gly Ala Ile Val Glu Tyr His Gly Pro Gly Val 
            260                 265                 270         


Asp Ser Ile Ser Cys Thr Gly Met Ala Thr Ile Cys Asn Met Gly Ala 
        275                 280                 285             


Glu Ile Gly Ala Thr Thr Ser Val Phe Pro Tyr Asn His Arg Met Lys 
    290                 295                 300                 


Lys Tyr Leu Ser Lys Thr Gly Arg Glu Asp Ile Ala Asn Leu Ala Asp 
305                 310                 315                 320 


Glu Phe Lys Asp His Leu Val Pro Asp Pro Gly Cys His Tyr Asp Gln 
                325                 330                 335     


Leu Ile Glu Ile Asn Leu Ser Glu Leu Lys Pro His Ile Asn Gly Pro 
            340                 345                 350         


Phe Thr Pro Asp Leu Ala His Pro Val Ala Glu Val Gly Lys Val Ala 
        355                 360                 365             


Glu Lys Glu Gly Trp Pro Leu Asp Ile Arg Val Gly Leu Ile Gly Ser 
    370                 375                 380                 


Cys Thr Asn Ser Ser Tyr Glu Asp Met Gly Arg Ser Ala Ala Val Ala 
385                 390                 395                 400 


Lys Gln Ala Leu Ala His Gly Leu Lys Cys Lys Ser Gln Phe Thr Ile 
                405                 410                 415     


Thr Pro Gly Ser Glu Gln Ile Arg Ala Thr Ile Glu Arg Asp Gly Tyr 
            420                 425                 430         


Ala Gln Ile Leu Arg Asp Leu Gly Gly Ile Val Leu Ala Asn Ala Cys 
        435                 440                 445             


Gly Pro Cys Ile Gly Gln Trp Asp Arg Lys Asp Ile Lys Lys Gly Glu 
    450                 455                 460                 


Lys Asn Thr Ile Val Thr Ser Tyr Asn Arg Asn Phe Thr Gly Arg Asn 
465                 470                 475                 480 


Asp Ala Asn Pro Glu Thr His Ala Phe Val Thr Ser Pro Glu Ile Val 
                485                 490                 495     


Thr Ala Leu Ala Ile Ala Gly Thr Leu Lys Phe Asn Pro Glu Thr Asp 
            500                 505                 510         


Tyr Leu Thr Gly Thr Asp Gly Lys Lys Phe Arg Leu Glu Ala Pro Asp 
        515                 520                 525             


Ala Asp Glu Leu Pro Lys Gly Glu Phe Asp Pro Gly Gln Asp Thr Tyr 
    530                 535                 540                 


Gln His Pro Pro Lys Asp Ser Ser Gly Gln His Val Asp Val Ser Pro 
545                 550                 555                 560 


Thr Ser Gln Arg Leu Gln Leu Leu Glu Pro Phe Asp Lys Trp Asp Gly 
                565                 570                 575     


Lys Asp Leu Glu Asp Leu Gln Ile Leu Ile Lys Val Lys Gly Lys Cys 
            580                 585                 590         


Thr Thr Asp His Ile Ser Ala Ala Gly Pro Trp Leu Lys Phe Arg Gly 
        595                 600                 605             


His Leu Asp Asn Ile Ser Asn Asn Leu Leu Ile Gly Ala Ile Asn Ile 
    610                 615                 620                 


Glu Asn Gly Lys Ala Asn Ser Val Arg Asn Ala Val Thr Gln Glu Phe 
625                 630                 635                 640 


Gly Pro Val Pro Asp Thr Ala Arg Tyr Tyr Lys Lys His Gly Ile Arg 
                645                 650                 655     


Trp Val Val Ile Gly Asp Glu Asn Tyr Gly Glu Gly Ser Ser Arg Glu 
            660                 665                 670         


His Ala Ala Leu Glu Pro Arg His Leu Gly Gly Arg Ala Ile Ile Thr 
        675                 680                 685             


Lys Ser Phe Ala Arg Ile His Glu Thr Asn Leu Lys Lys Gln Gly Leu 
    690                 695                 700                 


Leu Pro Leu Thr Phe Ala Asp Pro Ala Asp Tyr Asn Lys Ile His Pro 
705                 710                 715                 720 


Val Asp Lys Leu Thr Ile Gln Gly Leu Lys Asp Phe Thr Pro Gly Lys 
                725                 730                 735     


Pro Leu Lys Cys Ile Ile Lys His Pro Asn Gly Thr Gln Glu Thr Ile 
            740                 745                 750         


Leu Leu Asn His Thr Phe Asn Glu Thr Gln Ile Glu Trp Phe Arg Ala 
        755                 760                 765             


Gly Ser Ala Leu Asn Arg Met Lys Glu Leu Gln Gln 
    770                 775                 780 


<210>  74
<211>  2283
<212>  DNA
<213>  Homo sapiens

<400>  74
atgatggatc aagctagatc agcattctct aacttgtttg gtggagaacc attgtcatat       60

acccggttca gcctggctcg gcaagtagat ggcgataaca gtcatgtgga gatgaaactt      120

gctgtagatg aagaagaaaa tgctgacaat aacacaaagg ccaatgtcac aaaaccaaaa      180

aggtgtagtg gaagtatctg ctatgggact attgctgtga tcgtcttttt cttgattgga      240

tttatgattg gctacttggg ctattgtaaa ggggtagaac caaaaactga gtgtgagaga      300

ctggcaggaa ccgagtctcc agtgagggag gagccaggag aggacttccc tgcagcacgt      360

cgcttatatt gggatgacct gaagagaaag ttgtcggaga aactggacag cacagacttc      420

accggcacca tcaagctgct gaatgaaaat tcatatgtcc ctcgtgaggc tggatctcaa      480

aaagatgaaa atcttgcgtt gtatgttgaa aatcaatttc gtgaatttaa actcagcaaa      540

gtctggcgtg atcaacattt tgttaagatt caggtcaaag acagcgctca aaactcggtg      600

atcatagttg ataagaacgg tagacttgtt tacctggtgg agaatcctgg gggttatgtg      660

gcgtatagta aggctgcaac agttactggt aaactggtcc atgctaattt tggtactaaa      720

aaagattttg aggatttata cactcctgtg aatggatcta tagtgattgt cagagcaggg      780

aaaatcacct ttgcagaaaa ggttgcaaat gctgaaagct taaatgcaat tggtgtgttg      840

atatacatgg accagactaa atttcccatt gttaacgcag aactttcatt ctttggacat      900

gctcatctgg ggacaggtga cccttacaca cctggattcc cttccttcaa tcacactcag      960

tttccaccat ctcggtcatc aggattgcct aatatacctg tccagacaat ctccagagct     1020

gctgcagaaa agctgtttgg gaatatggaa ggagactgtc cctctgactg gaaaacagac     1080

tctacatgta ggatggtaac ctcagaaagc aagaatgtga agctcactgt gagcaatgtg     1140

ctgaaagaga taaaaattct taacatcttt ggagttatta aaggctttgt agaaccagat     1200

cactatgttg tagttggggc ccagagagat gcatggggcc ctggagctgc aaaatccggt     1260

gtaggcacag ctctcctatt gaaacttgcc cagatgttct cagatatggt cttaaaagat     1320

gggtttcagc ccagcagaag cattatcttt gccagttgga gtgctggaga ctttggatcg     1380

gttggtgcca ctgaatggct agagggatac ctttcgtccc tgcatttaaa ggctttcact     1440

tatattaatc tggataaagc ggttcttggt accagcaact tcaaggtttc tgccagccca     1500

ctgttgtata cgcttattga gaaaacaatg caaaatgtga agcatccggt tactgggcaa     1560

tttctatatc aggacagcaa ctgggccagc aaagttgaga aactcacttt agacaatgct     1620

gctttccctt tccttgcata ttctggaatc ccagcagttt ctttctgttt ttgcgaggac     1680

acagattatc cttatttggg taccaccatg gacacctata aggaactgat tgagaggatt     1740

cctgagttga acaaagtggc acgagcagct gcagaggtcg ctggtcagtt cgtgattaaa     1800

ctaacccatg atgttgaatt gaacctggac tatgagaggt acaacagcca actgctttca     1860

tttgtgaggg atctgaacca atacagagca gacataaagg aaatgggcct gagtttacag     1920

tggctgtatt ctgctcgtgg agacttcttc cgtgctactt ccagactaac aacagatttc     1980

gggaatgctg agaaaacaga cagatttgtc atgaagaaac tcaatgatcg tgtcatgaga     2040

gtggagtatc acttcctctc tccctacgta tctccaaaag agtctccttt ccgacatgtc     2100

ttctggggct ccggctctca cacgctgcca gctttactgg agaacttgaa actgcgtaaa     2160

caaaataacg gtgcttttaa tgaaacgctg ttcagaaacc agttggctct agctacttgg     2220

actattcagg gagctgcaaa tgccctctct ggtgacgttt gggacattga caatgagttt     2280

taa                                                                   2283


<210>  75
<211>  2283
<212>  DNA
<213>  Homo sapiens

<400>  75
atgatggatc aagctagatc agcattctct aacttgtttg gtggagaacc attgtcatat       60

acccggttca gcctggctcg gcaagtagat ggcgataaca gtcatgtgga gatgaaactt      120

gctgtagatg aagaagaaaa tgctgacaat aacacaaagg ccaatgtcac aaaaccaaaa      180

aggtgtagtg gaagtatctg ctatgggact attgctgtga tcgtcttttt cttgattgga      240

tttatgattg gctacttggg ctattgtaaa ggggtagaac caaaaactga gtgtgagaga      300

ctggcaggaa ccgagtctcc agtgagggag gagccaggag aggacttccc tgcagcacgt      360

cgcttatatt gggatgacct gaagagaaag ttgtcggaga aactggacag cacagacttc      420

accggcacca tcaagctgct gaatgaaaat tcatatgtcc ctcgtgaggc tggatctcaa      480

aaagatgaaa atcttgcgtt gtatgttgaa aatcaatttc gtgaatttaa actcagcaaa      540

gtctggcgtg atcaacattt tgttaagatt caggtcaaag acagcgctca aaactcggtg      600

atcatagttg ataagaacgg tagacttgtt tacctggtgg agaatcctgg gggttatgtg      660

gcgtatagta aggctgcaac agttactggt aaactggtcc atgctaattt tggtactaaa      720

aaagattttg aggatttata cactcctgtg aatggatcta tagtgattgt cagagcaggg      780

aaaatcacct ttgcagaaaa ggttgcaaat gctgaaagct taaatgcaat tggtgtgttg      840

atatacatgg accagactaa atttcccatt gttaacgcag aactttcatt ctttggacat      900

gctcatctgg ggacaggtga cccttacaca cctggattcc cttccttcaa tcacactcag      960

tttccaccat ctcggtcatc aggattgcct aatatacctg tccagacaat ctccagagct     1020

gctgcagaaa agctgtttgg gaatatggaa ggagactgtc cctctgactg gaaaacagac     1080

tctacatgta ggatggtaac ctcagaaagc aagaatgtga agctcactgt gagcaatgtg     1140

ctgaaagaga taaaaattct taacatcttt ggagttatta aaggctttgt agaaccagat     1200

cactatgttg tagttggggc ccagagagat gcatggggcc ctggagctgc aaaatccggt     1260

gtaggcacag ctctcctatt gaaacttgcc cagatgttct cagatatggt cttaaaagat     1320

gggtttcagc ccagcagaag cattatcttt gccagttgga gtgctggaga ctttggatcg     1380

gttggtgcca ctgaatggct agagggatac ctttcgtccc tgcatttaaa ggctttcact     1440

tatattaatc tggataaagc ggttcttggt accagcaact tcaaggtttc tgccagccca     1500

ctgttgtata cgcttattga gaaaacaatg caaaatgtga agcatccggt tactgggcaa     1560

tttctatatc aggacagcaa ctgggccagc aaagttgaga aactcacttt agacaatgct     1620

gctttccctt tccttgcata ttctggaatc ccagcagttt ctttctgttt ttgcgaggac     1680

acagattatc cttatttggg taccaccatg gacacctata aggaactgat tgagaggatt     1740

cctgagttga acaaagtggc acgagcagct gcagaggtcg ctggtcagtt cgtgattaaa     1800

ctaacccatg atgttgaatt gaacctggac tatgagaggt acaacagcca actgctttca     1860

tttgtgaggg atctgaacca atacagagca gacataaagg aaatgggcct gagtttacag     1920

tggctgtatt ctgctcgtgg agacttcttc cgtgctactt ccagactaac aacagatttc     1980

gggaatgctg agaaaacaga cagatttgtc atgaagaaac tcaatgatcg tgtcatgaga     2040

gtggagtatc acttcctctc tccctacgta tctccaaaag agtctccttt ccgacatgtc     2100

ttctggggct ccggctctca cacgctgcca gctttactgg agaacttgaa actgcgtaaa     2160

caaaataacg gtgcttttaa tgaaacgctg ttcagaaacc agttggctct agctacttgg     2220

actattcagg gagctgcaaa tgccctctct ggtgacgttt gggacattga caatgagttt     2280

taa                                                                   2283


<210>  76
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  77
<211>  2406
<212>  DNA
<213>  Homo sapiens

<400>  77
atggagcggc tttggggtct attccagaga gcgcaacaac tgtccccaag atcctctcag       60

accgtctacc agcgtgtgga aggcccccgg aaagggcacc tggaggagga agaggaagac      120

ggggaggagg gggcggagac attggcccac ttctgcccca tggagctgag gggccctgag      180

cccctgggct ctagacccag gcagccaaac ctcattccct gggcggcagc aggacggagg      240

gctgccccct acctggtcct gacggccctg ctgatcttca ctggggcctt cctactgggc      300

tacgtcgcct tccgagggtc ctgccaggcg tgcggagact ctgtgttggt ggtcagtgag      360

gatgtcaact atgagcctga cctggatttc caccagggca gactctactg gagcgacctc      420

caggccatgt tcctgcagtt cctgggggag gggcgcctgg aggacaccat caggcaaacc      480

agccttcggg aacgggtggc aggctcggcc gggatggccg ctctgactca ggacattcgc      540

gcggcgctct cccgccagaa gctggaccac gtgtggaccg acacgcacta cgtggggctg      600

caattcccgg atccggctca ccccaacacc ctgcactggg tcgatgaggc cgggaaggtc      660

ggagagcagc tgccgctgga ggaccctgac gtctactgcc cctacagcgc catcggcaac      720

gtcacgggag agctggtgta cgcccactac gggcggcccg aagacctgca ggacctgcgg      780

gccaggggcg tggatccagt gggccgcctg ctgctggtgc gcgtgggggt gatcagcttc      840

gcccagaagg tgaccaatgc tcaggacttc ggggctcaag gagtgctcat atacccagag      900

ccagcggact tctcccagga cccacccaag ccaagcctgt ccagccagca ggcagtgtat      960

ggacatgtgc acctgggaac tggagacccc tacacacctg gcttcccttc cttcaatcaa     1020

acccagttcc ctccagttgc atcatcaggc cttcccagca tcccagccca gcccatcagt     1080

gcagacattg cctcccgcct gctgaggaag ctcaaaggcc ctgtggcccc ccaagaatgg     1140

caggggagcc tcctaggctc cccttatcac ctgggccccg ggccacgact gcggctagtg     1200

gtcaacaatc acaggacctc cacccccatc aacaacatct tcggctgcat cgaaggccgc     1260

tcagagccag atcactacgt tgtcatcggg gcccagaggg atgcatgggg cccaggagca     1320

gctaaatccg ctgtggggac ggctatactc ctggagctgg tgcggacctt ttcctccatg     1380

gtgagcaacg gcttccggcc ccgcagaagt ctcctcttca tcagctggga cggtggtgac     1440

tttggaagcg tgggctccac ggagtggcta gagggctacc tcagcgtgct gcacctcaaa     1500

gccgtagtgt acgtgagcct ggacaacgca gtgctggggg atgacaagtt tcatgccaag     1560

accagccccc ttctgacaag tctcattgag agtgtcctga agcaggtgga ttctcccaac     1620

cacagtgggc agactctcta tgaacaggtg gtgttcacca atcccagctg ggatgctgag     1680

gtgatccggc ccctacccat ggacagcagt gcctattcct tcacggcctt tgtgggagtc     1740

cctgccgtcg agttctcctt tatggaggac gaccaggcct acccattcct gcacacaaag     1800

gaggacactt atgagaacct gcataaggtg ctgcaaggcc gcctgcccgc cgtggcccag     1860

gccgtggccc agctcgcagg gcagctcctc atccggctca gccacgatcg cctgctgccc     1920

ctcgacttcg gccgctacgg ggacgtcgtc ctcaggcaca tcgggaacct caacgagttc     1980

tctggggacc tcaaggcccg cgggctgacc ctgcagtggg tgtactcggc gcggggggac     2040

tacatccggg cggcggaaaa gctgcggcag gagatctaca gctcggagga gagagacgag     2100

cgactgacac gcatgtacaa cgtgcgcata atgcgggtgg agttctactt cctttcccag     2160

tacgtgtcgc cagccgactc cccgttccgc cacatcttca tgggccgtgg agaccacacg     2220

ctgggcgccc tgctggacca cctgcggctg ctgcgctcca acagctccgg gacccccggg     2280

gccacctcct ccactggctt ccaggagagc cgtttccggc gtcagctagc cctgctcacc     2340

tggacgctgc aaggggcagc caatgcgctt agcggggatg tctggaacat tgataacaac     2400

ttctga                                                                2406


<210>  78
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Glu Arg Leu Trp Gly Leu Phe Gln Arg Ala Gln Gln Leu Ser Pro 
1               5                   10                  15      


Arg Ser Ser Gln Thr Val Tyr Gln Arg Val Glu Gly Pro Arg Lys Gly 
            20                  25                  30          


His Leu Glu Glu Glu Glu Glu Asp Gly Glu Glu Gly Ala Glu Thr Leu 
        35                  40                  45              


Ala His Phe Cys Pro Met Glu Leu Arg Gly Pro Glu Pro Leu Gly Ser 
    50                  55                  60                  


Arg Pro Arg Gln Pro Asn Leu Ile Pro Trp Ala Ala Ala Gly Arg Arg 
65                  70                  75                  80  


Ala Ala Pro Tyr Leu Val Leu Thr Ala Leu Leu Ile Phe Thr Gly Ala 
                85                  90                  95      


Phe Leu Leu Gly Tyr Val Ala Phe Arg Gly Ser Cys Gln Ala Cys Gly 
            100                 105                 110         


Asp Ser Val Leu Val Val Ser Glu Asp Val Asn Tyr Glu Pro Asp Leu 
        115                 120                 125             


Asp Phe His Gln Gly Arg Leu Tyr Trp Ser Asp Leu Gln Ala Met Phe 
    130                 135                 140                 


Leu Gln Phe Leu Gly Glu Gly Arg Leu Glu Asp Thr Ile Arg Gln Thr 
145                 150                 155                 160 


Ser Leu Arg Glu Arg Val Ala Gly Ser Ala Gly Met Ala Ala Leu Thr 
                165                 170                 175     


Gln Asp Ile Arg Ala Ala Leu Ser Arg Gln Lys Leu Asp His Val Trp 
            180                 185                 190         


Thr Asp Thr His Tyr Val Gly Leu Gln Phe Pro Asp Pro Ala His Pro 
        195                 200                 205             


Asn Thr Leu His Trp Val Asp Glu Ala Gly Lys Val Gly Glu Gln Leu 
    210                 215                 220                 


Pro Leu Glu Asp Pro Asp Val Tyr Cys Pro Tyr Ser Ala Ile Gly Asn 
225                 230                 235                 240 


Val Thr Gly Glu Leu Val Tyr Ala His Tyr Gly Arg Pro Glu Asp Leu 
                245                 250                 255     


Gln Asp Leu Arg Ala Arg Gly Val Asp Pro Val Gly Arg Leu Leu Leu 
            260                 265                 270         


Val Arg Val Gly Val Ile Ser Phe Ala Gln Lys Val Thr Asn Ala Gln 
        275                 280                 285             


Asp Phe Gly Ala Gln Gly Val Leu Ile Tyr Pro Glu Pro Ala Asp Phe 
    290                 295                 300                 


Ser Gln Asp Pro Pro Lys Pro Ser Leu Ser Ser Gln Gln Ala Val Tyr 
305                 310                 315                 320 


Gly His Val His Leu Gly Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro 
                325                 330                 335     


Ser Phe Asn Gln Thr Gln Phe Pro Pro Val Ala Ser Ser Gly Leu Pro 
            340                 345                 350         


Ser Ile Pro Ala Gln Pro Ile Ser Ala Asp Ile Ala Ser Arg Leu Leu 
        355                 360                 365             


Arg Lys Leu Lys Gly Pro Val Ala Pro Gln Glu Trp Gln Gly Ser Leu 
    370                 375                 380                 


Leu Gly Ser Pro Tyr His Leu Gly Pro Gly Pro Arg Leu Arg Leu Val 
385                 390                 395                 400 


Val Asn Asn His Arg Thr Ser Thr Pro Ile Asn Asn Ile Phe Gly Cys 
                405                 410                 415     


Ile Glu Gly Arg Ser Glu Pro Asp His Tyr Val Val Ile Gly Ala Gln 
            420                 425                 430         


Arg Asp Ala Trp Gly Pro Gly Ala Ala Lys Ser Ala Val Gly Thr Ala 
        435                 440                 445             


Ile Leu Leu Glu Leu Val Arg Thr Phe Ser Ser Met Val Ser Asn Gly 
    450                 455                 460                 


Phe Arg Pro Arg Arg Ser Leu Leu Phe Ile Ser Trp Asp Gly Gly Asp 
465                 470                 475                 480 


Phe Gly Ser Val Gly Ser Thr Glu Trp Leu Glu Gly Tyr Leu Ser Val 
                485                 490                 495     


Leu His Leu Lys Ala Val Val Tyr Val Ser Leu Asp Asn Ala Val Leu 
            500                 505                 510         


Gly Asp Asp Lys Phe His Ala Lys Thr Ser Pro Leu Leu Thr Ser Leu 
        515                 520                 525             


Ile Glu Ser Val Leu Lys Gln Val Asp Ser Pro Asn His Ser Gly Gln 
    530                 535                 540                 


Thr Leu Tyr Glu Gln Val Val Phe Thr Asn Pro Ser Trp Asp Ala Glu 
545                 550                 555                 560 


Val Ile Arg Pro Leu Pro Met Asp Ser Ser Ala Tyr Ser Phe Thr Ala 
                565                 570                 575     


Phe Val Gly Val Pro Ala Val Glu Phe Ser Phe Met Glu Asp Asp Gln 
            580                 585                 590         


Ala Tyr Pro Phe Leu His Thr Lys Glu Asp Thr Tyr Glu Asn Leu His 
        595                 600                 605             


Lys Val Leu Gln Gly Arg Leu Pro Ala Val Ala Gln Ala Val Ala Gln 
    610                 615                 620                 


Leu Ala Gly Gln Leu Leu Ile Arg Leu Ser His Asp Arg Leu Leu Pro 
625                 630                 635                 640 


Leu Asp Phe Gly Arg Tyr Gly Asp Val Val Leu Arg His Ile Gly Asn 
                645                 650                 655     


Leu Asn Glu Phe Ser Gly Asp Leu Lys Ala Arg Gly Leu Thr Leu Gln 
            660                 665                 670         


Trp Val Tyr Ser Ala Arg Gly Asp Tyr Ile Arg Ala Ala Glu Lys Leu 
        675                 680                 685             


Arg Gln Glu Ile Tyr Ser Ser Glu Glu Arg Asp Glu Arg Leu Thr Arg 
    690                 695                 700                 


Met Tyr Asn Val Arg Ile Met Arg Val Glu Phe Tyr Phe Leu Ser Gln 
705                 710                 715                 720 


Tyr Val Ser Pro Ala Asp Ser Pro Phe Arg His Ile Phe Met Gly Arg 
                725                 730                 735     


Gly Asp His Thr Leu Gly Ala Leu Leu Asp His Leu Arg Leu Leu Arg 
            740                 745                 750         


Ser Asn Ser Ser Gly Thr Pro Gly Ala Thr Ser Ser Thr Gly Phe Gln 
        755                 760                 765             


Glu Ser Arg Phe Arg Arg Gln Leu Ala Leu Leu Thr Trp Thr Leu Gln 
    770                 775                 780                 


Gly Ala Ala Asn Ala Leu Ser Gly Asp Val Trp Asn Ile Asp Asn Asn 
785                 790                 795                 800 


Phe 
    


<210>  79
<211>  1893
<212>  DNA
<213>  Homo sapiens

<400>  79
atggccgctc tgactcagga cattcgcgcg gcgctctccc gccagaagct ggaccacgtg       60

tggaccgaca cgcactacgt ggggctgcaa ttcccggatc cggctcaccc caacaccctg      120

cactgggtcg atgaggccgg gaaggtcgga gagcagctgc cgctggagga ccctgacgtc      180

tactgcccct acagcgccat cggcaacgtc acgggagagc tggtgtacgc ccactacggg      240

cggcccgaag acctgcagga cctgcgggcc aggggcgtgg atccagtggg ccgcctgctg      300

ctggtgcgcg tgggggtgat cagcttcgcc cagaaggtga ccaatgctca ggacttcggg      360

gctcaaggag tgctcatata cccagagcca gcggacttct cccaggaccc acccaagcca      420

agcctgtcca gccagcaggc agtgtatgga catgtgcacc tgggaactgg agacccctac      480

acacctggct tcccttcctt caatcaaacc cagttccctc cagttgcatc atcaggcctt      540

cccagcatcc cagcccagcc catcagtgca gacattgcct cccgcctgct gaggaagctc      600

aaaggccctg tggcccccca agaatggcag gggagcctcc taggctcccc ttatcacctg      660

ggccccgggc cacgactgcg gctagtggtc aacaatcaca ggacctccac ccccatcaac      720

aacatcttcg gctgcatcga aggccgctca gagccagatc actacgttgt catcggggcc      780

cagagggatg catggggccc aggagcagct aaatccgctg tggggacggc tatactcctg      840

gagctggtgc ggaccttttc ctccatggtg agcaacggct tccggccccg cagaagtctc      900

ctcttcatca gctgggacgg tggtgacttt ggaagcgtgg gctccacgga gtggctagaa      960

ggctacctca gcgtgctgca cctcaaagcc gtagtgtacg tgagcctgga caacgcagtg     1020

ctgggggatg acaagtttca tgccaagacc agcccccttc tgacaagtct cattgagagt     1080

gtcctgaagc aggtggattc tcccaaccac agtgggcaga ctctctatga acaggtggtg     1140

ttcaccaatc ccagctggga tgctgaggtg atccggcccc tacccatgga cagcagtgcc     1200

tattccttca cggcctttgt gggagtccct gccgtcgagt tctcctttat ggaggacgac     1260

caggcctacc cattcctgca cacaaaggag gacacttatg agaacctgca taaggtgctg     1320

caaggccgcc tgcccgccgt ggcccaggcc gtggcccagc tcgcagggca gctcctcatc     1380

cggctcagcc acgatcgcct gctgcccctc gacttcggcc gctacgggga cgtcgtcctc     1440

aggcacatcg ggaacctcaa cgagttctct ggggacctca aggcccgcgg gctgaccctg     1500

cagtgggtgt actcggcgcg gggggactac atccgggcgg cggaaaagct gcggcaggag     1560

atctacagct cggaggagag agacgagcga ctgacacgca tgtacaacgt gcgcataatg     1620

cgggtggagt tctacttcct ttcccagtac gtgtcgccag ccgactcccc gttccgccac     1680

atcttcatgg gccgtggaga ccacacgctg ggcgccctgc tggaccacct gcggctgctg     1740

cgctccaaca gctccgggac ccccggggcc acctcctcca ctggcttcca ggagagccgt     1800

ttccggcgtc agctagccct gctcacctgg acgctgcaag gggcagccaa tgcgcttagc     1860

ggggatgtct ggaacattga taacaacttc tga                                  1893


<210>  80
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ala Ala Leu Thr Gln Asp Ile Arg Ala Ala Leu Ser Arg Gln Lys 
1               5                   10                  15      


Leu Asp His Val Trp Thr Asp Thr His Tyr Val Gly Leu Gln Phe Pro 
            20                  25                  30          


Asp Pro Ala His Pro Asn Thr Leu His Trp Val Asp Glu Ala Gly Lys 
        35                  40                  45              


Val Gly Glu Gln Leu Pro Leu Glu Asp Pro Asp Val Tyr Cys Pro Tyr 
    50                  55                  60                  


Ser Ala Ile Gly Asn Val Thr Gly Glu Leu Val Tyr Ala His Tyr Gly 
65                  70                  75                  80  


Arg Pro Glu Asp Leu Gln Asp Leu Arg Ala Arg Gly Val Asp Pro Val 
                85                  90                  95      


Gly Arg Leu Leu Leu Val Arg Val Gly Val Ile Ser Phe Ala Gln Lys 
            100                 105                 110         


Val Thr Asn Ala Gln Asp Phe Gly Ala Gln Gly Val Leu Ile Tyr Pro 
        115                 120                 125             


Glu Pro Ala Asp Phe Ser Gln Asp Pro Pro Lys Pro Ser Leu Ser Ser 
    130                 135                 140                 


Gln Gln Ala Val Tyr Gly His Val His Leu Gly Thr Gly Asp Pro Tyr 
145                 150                 155                 160 


Thr Pro Gly Phe Pro Ser Phe Asn Gln Thr Gln Phe Pro Pro Val Ala 
                165                 170                 175     


Ser Ser Gly Leu Pro Ser Ile Pro Ala Gln Pro Ile Ser Ala Asp Ile 
            180                 185                 190         


Ala Ser Arg Leu Leu Arg Lys Leu Lys Gly Pro Val Ala Pro Gln Glu 
        195                 200                 205             


Trp Gln Gly Ser Leu Leu Gly Ser Pro Tyr His Leu Gly Pro Gly Pro 
    210                 215                 220                 


Arg Leu Arg Leu Val Val Asn Asn His Arg Thr Ser Thr Pro Ile Asn 
225                 230                 235                 240 


Asn Ile Phe Gly Cys Ile Glu Gly Arg Ser Glu Pro Asp His Tyr Val 
                245                 250                 255     


Val Ile Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala Ala Lys Ser 
            260                 265                 270         


Ala Val Gly Thr Ala Ile Leu Leu Glu Leu Val Arg Thr Phe Ser Ser 
        275                 280                 285             


Met Val Ser Asn Gly Phe Arg Pro Arg Arg Ser Leu Leu Phe Ile Ser 
    290                 295                 300                 


Trp Asp Gly Gly Asp Phe Gly Ser Val Gly Ser Thr Glu Trp Leu Glu 
305                 310                 315                 320 


Gly Tyr Leu Ser Val Leu His Leu Lys Ala Val Val Tyr Val Ser Leu 
                325                 330                 335     


Asp Asn Ala Val Leu Gly Asp Asp Lys Phe His Ala Lys Thr Ser Pro 
            340                 345                 350         


Leu Leu Thr Ser Leu Ile Glu Ser Val Leu Lys Gln Val Asp Ser Pro 
        355                 360                 365             


Asn His Ser Gly Gln Thr Leu Tyr Glu Gln Val Val Phe Thr Asn Pro 
    370                 375                 380                 


Ser Trp Asp Ala Glu Val Ile Arg Pro Leu Pro Met Asp Ser Ser Ala 
385                 390                 395                 400 


Tyr Ser Phe Thr Ala Phe Val Gly Val Pro Ala Val Glu Phe Ser Phe 
                405                 410                 415     


Met Glu Asp Asp Gln Ala Tyr Pro Phe Leu His Thr Lys Glu Asp Thr 
            420                 425                 430         


Tyr Glu Asn Leu His Lys Val Leu Gln Gly Arg Leu Pro Ala Val Ala 
        435                 440                 445             


Gln Ala Val Ala Gln Leu Ala Gly Gln Leu Leu Ile Arg Leu Ser His 
    450                 455                 460                 


Asp Arg Leu Leu Pro Leu Asp Phe Gly Arg Tyr Gly Asp Val Val Leu 
465                 470                 475                 480 


Arg His Ile Gly Asn Leu Asn Glu Phe Ser Gly Asp Leu Lys Ala Arg 
                485                 490                 495     


Gly Leu Thr Leu Gln Trp Val Tyr Ser Ala Arg Gly Asp Tyr Ile Arg 
            500                 505                 510         


Ala Ala Glu Lys Leu Arg Gln Glu Ile Tyr Ser Ser Glu Glu Arg Asp 
        515                 520                 525             


Glu Arg Leu Thr Arg Met Tyr Asn Val Arg Ile Met Arg Val Glu Phe 
    530                 535                 540                 


Tyr Phe Leu Ser Gln Tyr Val Ser Pro Ala Asp Ser Pro Phe Arg His 
545                 550                 555                 560 


Ile Phe Met Gly Arg Gly Asp His Thr Leu Gly Ala Leu Leu Asp His 
                565                 570                 575     


Leu Arg Leu Leu Arg Ser Asn Ser Ser Gly Thr Pro Gly Ala Thr Ser 
            580                 585                 590         


Ser Thr Gly Phe Gln Glu Ser Arg Phe Arg Arg Gln Leu Ala Leu Leu 
        595                 600                 605             


Thr Trp Thr Leu Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp Val Trp 
    610                 615                 620                 


Asn Ile Asp Asn Asn Phe 
625                 630 


<210>  81
<211>  2613
<212>  DNA
<213>  Homo sapiens

<400>  81
atgacagctg acaaggagaa gaaaaggagt agctcggaga ggaggaagga gaagtcccgg       60

gatgctgcgc ggtgccggcg gagcaaggag acggaggtgt tctatgagct ggcccatgag      120

ctgcctctgc cccacagtgt gagctcccat ctggacaagg cctccatcat gcgactggca      180

atcagcttcc tgcgaacaca caagctcctc tcctcagttt gctctgaaaa cgagtccgaa      240

gccgaagctg accagcagat ggacaacttg tacctgaaag ccttggaggg tttcattgcc      300

gtggtgaccc aagatggcga catgatcttt ctgtcagaaa acatcagcaa gttcatggga      360

cttacacagg tggagctaac aggacatagt atctttgact tcactcatcc ctgcgaccat      420

gaggagattc gtgagaacct gagtctcaaa aatggctctg gttttgggaa aaaaagcaaa      480

gacatgtcca cagagcggga cttcttcatg aggatgaagt gcacggtcac caacagaggc      540

cgtactgtca acctcaagtc agccacctgg aaggtcttgc actgcacggg ccaggtgaaa      600

gtctacaaca actgccctcc tcacaatagt ctgtgtggct acaaggagcc cctgctgtcc      660

tgcctcatca tcatgtgtga accaatccag cacccatccc acatggacat ccccctggat      720

agcaagacct tcctgagccg ccacagcatg gacatgaagt tcacctactg tgatgacaga      780

atcacagaac tgattggtta ccaccctgag gagctgcttg gccgctcagc ctatgaattc      840

taccatgcgc tagactccga gaacatgacc aagagtcacc agaacttgtg caccaagggt      900

caggtagtaa gtggccagta ccggatgctc gcaaagcatg ggggctacgt gtggctggag      960

acccagggga cggtcatcta caaccctcgc aacctgcagc cccagtgcat catgtgtgtc     1020

aactacgtcc tgagtgagat tgagaagaat gacgtggtgt tctccatgga ccagactgaa     1080

tccctgttca agccccacct gatggccatg aacagcatct ttgatagcag tggcaagggg     1140

gctgtgtctg agaagagtaa cttcctattc accaagctaa aggaggagcc cgaggagctg     1200

gcccagctgg ctcccacccc aggagacgcc atcatctctc tggatttcgg gaatcagaac     1260

ttcgaggagt cctcagccta tggcaaggcc atcctgcccc cgagccagcc atgggccacg     1320

gagttgagga gccacagcac ccagagcgag gctgggagcc tgcctgcctt caccgtgccc     1380

caggcagctg ccccgggcag caccaccccc agtgccacca gcagcagcag cagctgctcc     1440

acgcccaata gccctgaaga ctattacaca tctttggata acgacctgaa gattgaagtg     1500

attgagaagc tcttcgccat ggacacagag gccaaggacc aatgcagtac ccagacggat     1560

ttcaatgagc tggacttgga gacactggca ccctatatcc ccatggacgg ggaagacttc     1620

cagctaagcc ccatctgccc cgaggagcgg ctcttggcgg agaacccaca gtccaccccc     1680

cagcactgct tcagtgccat gacaaacatc ttccagccac tggcccctgt agccccgcac     1740

agtcccttcc tcctggacaa gtttcagcag cagctggaga gcaagaagac agagcccgag     1800

caccggccca tgtcctccat cttctttgat gccggaagca aagcatccct gccaccgtgc     1860

tgtggccagg ccagcacccc tctctcttcc atggggggca gatccaatac ccagtggccc     1920

ccagatccac cattacattt tgggcccaca aagtgggccg tcggggatca gcgcacagag     1980

ttcttgggag cagcgccgtt ggggccccct gtctctccac cccatgtctc caccttcaag     2040

acaaggtctg caaagggttt tggggctcga ggcccagacg tgctgagtcc ggccatggta     2100

gccctctcca acaagctgaa gctgaagcga cagctggagt atgaagagca agccttccag     2160

gacctgagcg ggggggaccc acctggtggc agcacctcac atttgatgtg gaaacggatg     2220

aagaacctca ggggtgggag ctgccctttg atgccggaca agccactgag cgcaaatgta     2280

cccaatgata agttcaccca aaaccccatg aggggcctgg gccatcccct gagacatctg     2340

ccgctgccac agcctccatc tgccatcagt cccggggaga acagcaagag caggttcccc     2400

ccacagtgct acgccaccca gtaccaggac tacagcctgt cgtcagccca caaggtgtca     2460

ggcatggcaa gccggctgct cgggccctca tttgagtcct acctgctgcc cgaactgacc     2520

agatatgact gtgaggtgaa cgtgcccgtg ctgggaagct ccacgctcct gcaaggaggg     2580

gacctcctca gagccctgga ccaggccacc tga                                  2613


<210>  82
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Thr Ala Asp Lys Glu Lys Lys Arg Ser Ser Ser Glu Arg Arg Lys 
1               5                   10                  15      


Glu Lys Ser Arg Asp Ala Ala Arg Cys Arg Arg Ser Lys Glu Thr Glu 
            20                  25                  30          


Val Phe Tyr Glu Leu Ala His Glu Leu Pro Leu Pro His Ser Val Ser 
        35                  40                  45              


Ser His Leu Asp Lys Ala Ser Ile Met Arg Leu Ala Ile Ser Phe Leu 
    50                  55                  60                  


Arg Thr His Lys Leu Leu Ser Ser Val Cys Ser Glu Asn Glu Ser Glu 
65                  70                  75                  80  


Ala Glu Ala Asp Gln Gln Met Asp Asn Leu Tyr Leu Lys Ala Leu Glu 
                85                  90                  95      


Gly Phe Ile Ala Val Val Thr Gln Asp Gly Asp Met Ile Phe Leu Ser 
            100                 105                 110         


Glu Asn Ile Ser Lys Phe Met Gly Leu Thr Gln Val Glu Leu Thr Gly 
        115                 120                 125             


His Ser Ile Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Ile Arg 
    130                 135                 140                 


Glu Asn Leu Ser Leu Lys Asn Gly Ser Gly Phe Gly Lys Lys Ser Lys 
145                 150                 155                 160 


Asp Met Ser Thr Glu Arg Asp Phe Phe Met Arg Met Lys Cys Thr Val 
                165                 170                 175     


Thr Asn Arg Gly Arg Thr Val Asn Leu Lys Ser Ala Thr Trp Lys Val 
            180                 185                 190         


Leu His Cys Thr Gly Gln Val Lys Val Tyr Asn Asn Cys Pro Pro His 
        195                 200                 205             


Asn Ser Leu Cys Gly Tyr Lys Glu Pro Leu Leu Ser Cys Leu Ile Ile 
    210                 215                 220                 


Met Cys Glu Pro Ile Gln His Pro Ser His Met Asp Ile Pro Leu Asp 
225                 230                 235                 240 


Ser Lys Thr Phe Leu Ser Arg His Ser Met Asp Met Lys Phe Thr Tyr 
                245                 250                 255     


Cys Asp Asp Arg Ile Thr Glu Leu Ile Gly Tyr His Pro Glu Glu Leu 
            260                 265                 270         


Leu Gly Arg Ser Ala Tyr Glu Phe Tyr His Ala Leu Asp Ser Glu Asn 
        275                 280                 285             


Met Thr Lys Ser His Gln Asn Leu Cys Thr Lys Gly Gln Val Val Ser 
    290                 295                 300                 


Gly Gln Tyr Arg Met Leu Ala Lys His Gly Gly Tyr Val Trp Leu Glu 
305                 310                 315                 320 


Thr Gln Gly Thr Val Ile Tyr Asn Pro Arg Asn Leu Gln Pro Gln Cys 
                325                 330                 335     


Ile Met Cys Val Asn Tyr Val Leu Ser Glu Ile Glu Lys Asn Asp Val 
            340                 345                 350         


Val Phe Ser Met Asp Gln Thr Glu Ser Leu Phe Lys Pro His Leu Met 
        355                 360                 365             


Ala Met Asn Ser Ile Phe Asp Ser Ser Gly Lys Gly Ala Val Ser Glu 
    370                 375                 380                 


Lys Ser Asn Phe Leu Phe Thr Lys Leu Lys Glu Glu Pro Glu Glu Leu 
385                 390                 395                 400 


Ala Gln Leu Ala Pro Thr Pro Gly Asp Ala Ile Ile Ser Leu Asp Phe 
                405                 410                 415     


Gly Asn Gln Asn Phe Glu Glu Ser Ser Ala Tyr Gly Lys Ala Ile Leu 
            420                 425                 430         


Pro Pro Ser Gln Pro Trp Ala Thr Glu Leu Arg Ser His Ser Thr Gln 
        435                 440                 445             


Ser Glu Ala Gly Ser Leu Pro Ala Phe Thr Val Pro Gln Ala Ala Ala 
    450                 455                 460                 


Pro Gly Ser Thr Thr Pro Ser Ala Thr Ser Ser Ser Ser Ser Cys Ser 
465                 470                 475                 480 


Thr Pro Asn Ser Pro Glu Asp Tyr Tyr Thr Ser Leu Asp Asn Asp Leu 
                485                 490                 495     


Lys Ile Glu Val Ile Glu Lys Leu Phe Ala Met Asp Thr Glu Ala Lys 
            500                 505                 510         


Asp Gln Cys Ser Thr Gln Thr Asp Phe Asn Glu Leu Asp Leu Glu Thr 
        515                 520                 525             


Leu Ala Pro Tyr Ile Pro Met Asp Gly Glu Asp Phe Gln Leu Ser Pro 
    530                 535                 540                 


Ile Cys Pro Glu Glu Arg Leu Leu Ala Glu Asn Pro Gln Ser Thr Pro 
545                 550                 555                 560 


Gln His Cys Phe Ser Ala Met Thr Asn Ile Phe Gln Pro Leu Ala Pro 
                565                 570                 575     


Val Ala Pro His Ser Pro Phe Leu Leu Asp Lys Phe Gln Gln Gln Leu 
            580                 585                 590         


Glu Ser Lys Lys Thr Glu Pro Glu His Arg Pro Met Ser Ser Ile Phe 
        595                 600                 605             


Phe Asp Ala Gly Ser Lys Ala Ser Leu Pro Pro Cys Cys Gly Gln Ala 
    610                 615                 620                 


Ser Thr Pro Leu Ser Ser Met Gly Gly Arg Ser Asn Thr Gln Trp Pro 
625                 630                 635                 640 


Pro Asp Pro Pro Leu His Phe Gly Pro Thr Lys Trp Ala Val Gly Asp 
                645                 650                 655     


Gln Arg Thr Glu Phe Leu Gly Ala Ala Pro Leu Gly Pro Pro Val Ser 
            660                 665                 670         


Pro Pro His Val Ser Thr Phe Lys Thr Arg Ser Ala Lys Gly Phe Gly 
        675                 680                 685             


Ala Arg Gly Pro Asp Val Leu Ser Pro Ala Met Val Ala Leu Ser Asn 
    690                 695                 700                 


Lys Leu Lys Leu Lys Arg Gln Leu Glu Tyr Glu Glu Gln Ala Phe Gln 
705                 710                 715                 720 


Asp Leu Ser Gly Gly Asp Pro Pro Gly Gly Ser Thr Ser His Leu Met 
                725                 730                 735     


Trp Lys Arg Met Lys Asn Leu Arg Gly Gly Ser Cys Pro Leu Met Pro 
            740                 745                 750         


Asp Lys Pro Leu Ser Ala Asn Val Pro Asn Asp Lys Phe Thr Gln Asn 
        755                 760                 765             


Pro Met Arg Gly Leu Gly His Pro Leu Arg His Leu Pro Leu Pro Gln 
    770                 775                 780                 


Pro Pro Ser Ala Ile Ser Pro Gly Glu Asn Ser Lys Ser Arg Phe Pro 
785                 790                 795                 800 


Pro Gln Cys Tyr Ala Thr Gln Tyr Gln Asp Tyr Ser Leu Ser Ser Ala 
                805                 810                 815     


His Lys Val Ser Gly Met Ala Ser Arg Leu Leu Gly Pro Ser Phe Glu 
            820                 825                 830         


Ser Tyr Leu Leu Pro Glu Leu Thr Arg Tyr Asp Cys Glu Val Asn Val 
        835                 840                 845             


Pro Val Leu Gly Ser Ser Thr Leu Leu Gln Gly Gly Asp Leu Leu Arg 
    850                 855                 860                 


Ala Leu Asp Gln Ala Thr 
865                 870 


<210>  83
<211>  1815
<212>  DNA
<213>  Homo sapiens

<400>  83
atgctcgccc gcgccctgct gctgtgcgcg gtcctggcgc tcagccatac agcaaatcct       60

tgctgttccc acccatgtca aaaccgaggt gtatgtatga gtgtgggatt tgaccagtat      120

aagtgcgatt gtacccggac aggattctat ggagaaaact gctcaacacc ggaatttttg      180

acaagaataa aattatttct gaaacccact ccaaacacag tgcactacat acttacccac      240

ttcaagggat tttggaacgt tgtgaataac attcccttcc ttcgaaatgc aattatgagt      300

tatgtgttga catccagatc acatttgatt gacagtccac caacttacaa tgctgactat      360

ggctacaaaa gctgggaagc cttctctaac ctctcctatt atactagagc ccttcctcct      420

gtgcctgatg attgcccgac tcccttgggt gtcaaaggta aaaagcagct tcctgattca      480

aatgagattg tggaaaaatt gcttctaaga agaaagttca tccctgatcc ccagggctca      540

aacatgatgt ttgcattctt tgcccagcac ttcacgcatc agtttttcaa gacagatcat      600

aagcgagggc cagctttcac caacgggctg ggccatgggg tggacttaaa tcatatttac      660

ggtgaaactc tggctagaca gcgtaaactg cgccttttca aggatggaaa aatgaaatat      720

cagataattg atggagagat gtatcctccc acagtcaaag atactcaggc agagatgatc      780

taccctcctc aagtccctga gcatctacgg tttgctgtgg ggcaggaggt ctttggtctg      840

gtgcctggtc tgatgatgta tgccacaatc tggctgcggg aacacaacag agtatgcgat      900

gtgcttaaac aggagcatcc tgaatggggt gatgagcagt tgttccagac aagcaggcta      960

atactgatag gagagactat taagattgtg attgaagatt atgtgcaaca cttgagtggc     1020

tatcacttca aactgaaatt tgacccagaa ctacttttca acaaacaatt ccagtaccaa     1080

aatcgtattg ctgctgaatt taacaccctc tatcactggc atccccttct gcctgacacc     1140

tttcaaattc atgaccagaa atacaactat caacagttta tctacaacaa ctctatattg     1200

ctggaacatg gaattaccca gtttgttgaa tcattcacca ggcaaattgc tggcagggtt     1260

gctggtggta ggaatgttcc acccgcagta cagaaagtat cacaggcttc cattgaccag     1320

agcaggcaga tgaaatacca gtcttttaat gagtaccgca aacgctttat gctgaagccc     1380

tatgaatcat ttgaagaact tacaggagaa aaggaaatgt ctgcagagtt ggaagcactc     1440

tatggtgaca tcgatgctgt ggagctgtat cctgcccttc tggtagaaaa gcctcggcca     1500

gatgccatct ttggtgaaac catggtagaa gttggagcac cattctcctt gaaaggactt     1560

atgggtaatg ttatatgttc tcctgcctac tggaagccaa gcacttttgg tggagaagtg     1620

ggttttcaaa tcatcaacac tgcctcaatt cagtctctca tctgcaataa cgtgaagggc     1680

tgtcccttta cttcattcag tgttccagat ccagagctca ttaaaacagt caccatcaat     1740

gcaagttctt cccgctccgg actagatgat atcaatccca cagtactact aaaagaacgt     1800

tcgactgaac tgtag                                                      1815


<210>  84
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His 
1               5                   10                  15      


Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys 
            20                  25                  30          


Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 
        35                  40                  45              


Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys 
    50                  55                  60                  


Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 
65                  70                  75                  80  


Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn 
                85                  90                  95      


Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser 
            100                 105                 110         


Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 
        115                 120                 125             


Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp 
    130                 135                 140                 


Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser 
145                 150                 155                 160 


Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp 
                165                 170                 175     


Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr 
            180                 185                 190         


His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn 
        195                 200                 205             


Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu 
    210                 215                 220                 


Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr 
225                 230                 235                 240 


Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln 
                245                 250                 255     


Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala 
            260                 265                 270         


Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala 
        275                 280                 285             


Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln 
    290                 295                 300                 


Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu 
305                 310                 315                 320 


Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln 
                325                 330                 335     


His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu 
            340                 345                 350         


Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn 
        355                 360                 365             


Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His 
    370                 375                 380                 


Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu 
385                 390                 395                 400 


Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile 
                405                 410                 415     


Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys 
            420                 425                 430         


Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser 
        435                 440                 445             


Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe 
    450                 455                 460                 


Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu 
465                 470                 475                 480 


Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu 
                485                 490                 495     


Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly 
            500                 505                 510         


Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro 
        515                 520                 525             


Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile 
    530                 535                 540                 


Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly 
545                 550                 555                 560 


Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr 
                565                 570                 575     


Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn 
            580                 585                 590         


Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu 
        595                 600                 


<210>  85
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Oligo A sequence"

<400>  85
tttgcctctt ctccacagac a                                                 21


<210>  86
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1-1 shRNA target
       sequence"

<400>  86
gctactgaat ccaacaacat a                                                 21


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1-2 shRNA target
       sequence"

<400>  87
gcgcactctt ctatcaggtt t                                                 21


<210>  88
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1-3 shRNA target
       sequence"

<400>  88
ccacaagcga atctcaaagt t                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1-4 shRNA target
       sequence"

<400>  89
cagttccaga aaggtatatt t                                                 21


<210>  90
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1-5 shRNA target
       sequence"

<400>  90
ctgtgactcc accagttatt c                                                 21


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1-6 shRNA target
       sequence"

<400>  91
agcggctgat acagaatata a                                                 21


<210>  92
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1-7 shRNA target
       sequence"

<400>  92
gggaccctaa gcaccattat c                                                 21


<210>  93
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1-8 shRNA target
       sequence"

<400>  93
tgtgaagcgt cttcgagaaa t                                                 21


<210>  94
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NT1 shRNA target 
       sequence"

<400>  94
caacaagatg aagagcacca a                                                 21


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-LU2 shRNA target 
       sequence"

<400>  95
cttcgaaatg tccgttcggt t                                                 21


<210>  96
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-LUC3 shRNA target 
       sequence"

<400>  96
caaatcacag aatcgtcgta t                                                 21


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-KIF11 shRNA target 
       sequence"

<400>  97
gcgtacaaga acatctataa t                                                 21


<210>  98
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1_sh1 target 
       sequence"

<400>  98
gctactgaat ccaacaacat a                                                 21


<210>  99
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1_sh1 mutated 
       target sequence"

<400>  99
gcaacggagt cgaataatat c                                                 21


<210>  100
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1_sh4 target 
       sequence"

<400>  100
tgcagttcca gaaaggtata tttc                                              24


<210>  101
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1_sh4 mutated 
       target sequence"

<400>  101
tgtagctctc gcaaagtcta cttc                                              24


<210>  102
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1_sh6 target 
       sequence"

<400>  102
gagcggctga tacagaatat aatg                                              24


<210>  103
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-NFS1_sh6 mutated 
       target sequence"

<400>  103
gaacgcctta tccaaaacat tatg                                              24


<210>  104
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: NFS1_P1 synthetic 
       primer"

<400>  104
ggggacaact ttgtacaaaa aagttggcat gctgctccga gccgcttg                    48


<210>  105
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: NFS1_P2 synthetic 
       primer"

<400>  105
ggggacaact ttgtacaaga aagttgggct agtgttgggt ccacttga                    48


<210>  106
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: NFS1_SH1_P3 synthetic 
       primer"

<400>  106
gatattattc gactccgttg caccactagt aaaaatgatc t                           41


<210>  107
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: NFS1_SH1_P4 synthetic 
       primer"

<400>  107
gcaacggagt cgaataatat cgcaattaag ggggtggccc g                           41


<210>  108
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: NFS1_SH4_P3 synthetic 
       primer"

<400>  108
aagtagactt tgcgagagct acaaatccgc cctatttctg c                           41


<210>  109
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: NFS1_SH4_P4 synthetic 
       primer"

<400>  109
tagctctcgc aaagtctact tccatactga tgcagcccag g                           41


<210>  110
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: NFS1_SH6_P3 synthetic 
       primer"

<400>  110
taatgttttg gataaggcgt tctgacaact ttgagattcg c                           41


<210>  111
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: NFS1_SH6_P4 synthetic 
       primer"

<400>  111
aacgccttat ccaaaacatt atgaagagcc ttccagatgt g                           41