                               SEQUENCE LISTING

<110> JOSLIN DIABETES CENTER, INC.
 
<120> METHODS AND COMPOSITIONS FOR INDUCTION OF UCP1 EXPRESSION

<130> 123968-00020

<140>
<141> 2015-05-07

<150> 61/989,628
<151> 2014-05-07

<160> 56    

<170> PatentIn version 3.5

<210> 1
<211> 744
<212> DNA
<213> Homo sapiens

<400> 1
tttagggcca ttaattctga ccacgtgcct gagaggcaag gtggatggcc ctgggacaga       60

aactgttcat cactatgtcc cggggagcag gacgtctgca gggcacgctg tgggctctcg      120

tcttcctagg catcctagtg ggcatggtgg tgccctcgcc tgcaggcacc cgtgccaaca      180

acacgctgct ggactcgagg ggctggggca ccctgctgtc caggtctcgc gcggggctag      240

ctggagagat tgccggggtg aactgggaaa gtggctattt ggtggggatc aagcggcagc      300

ggaggctcta ctgcaacgtg ggcatcggct ttcacctcca ggtgctcccc gacggccgga      360

tcagcgggac ccacgaggag aacccctaca gcctgctgga aatttccact gtggagcgag      420

gcgtggtgag tctctttgga gtgagaagtg ccctcttcgt tgccatgaac agtaaaggaa      480

gattgtacgc aacgcccagc ttccaagaag aatgcaagtt cagagaaacc ctcctgccca      540

acaattacaa tgcctacgag tcagacttgt accaagggac ctacattgcc ctgagcaaat      600

acggacgggt aaagcggggc agcaaggtgt ccccgatcat gactgtcact catttccttc      660

ccaggatcta aggacccaca aaagaaggct tacagattta aagcatcatc tgttcgattg      720

aaattttgca ccagcgaaga attc                                             744


<210> 2
<211> 208
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Leu Gly Gln Lys Leu Phe Ile Thr Met Ser Arg Gly Ala Gly 
1               5                   10                  15      


Arg Leu Gln Gly Thr Leu Trp Ala Leu Val Phe Leu Gly Ile Leu Val 
            20                  25                  30          


Gly Met Val Val Pro Ser Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu 
        35                  40                  45              


Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly 
    50                  55                  60                  


Leu Ala Gly Glu Ile Ala Gly Val Asn Trp Glu Ser Gly Tyr Leu Val 
65                  70                  75                  80  


Gly Ile Lys Arg Gln Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe 
                85                  90                  95      


His Leu Gln Val Leu Pro Asp Gly Arg Ile Ser Gly Thr His Glu Glu 
            100                 105                 110         


Asn Pro Tyr Ser Leu Leu Glu Ile Ser Thr Val Glu Arg Gly Val Val 
        115                 120                 125             


Ser Leu Phe Gly Val Arg Ser Ala Leu Phe Val Ala Met Asn Ser Lys 
    130                 135                 140                 


Gly Arg Leu Tyr Ala Thr Pro Ser Phe Gln Glu Glu Cys Lys Phe Arg 
145                 150                 155                 160 


Glu Thr Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Asp Leu Tyr 
                165                 170                 175     


Gln Gly Thr Tyr Ile Ala Leu Ser Lys Tyr Gly Arg Val Lys Arg Gly 
            180                 185                 190         


Ser Lys Val Ser Pro Ile Met Thr Val Thr His Phe Leu Pro Arg Ile 
        195                 200                 205             


<210> 3
<211> 1232
<212> DNA
<213> Mus musculus

<400> 3
tttagggcca ttaattctga ccacgtgcct gagaggcaag gtggatggcc ctgggacaga       60

ggctgttcat cactatgtcc cggggagcag gacgtgttca gggcacgctg caggctctcg      120

tcttcttagg cgtcctagtg ggcatggtgg tgccctcacc tgccggcgcc cgcgccaacg      180

gcacgctact ggactccaga ggctggggca ccctcttgtc caggtctcga gctgggctag      240

ctggagagat ttcgggtgtg aattgggaaa gcggctattt ggtgggcatt aagcgacagc      300

ggagactcta ctgcaacgtg ggcattggct tccacctcca ggtgcctcct gacggccgca      360

tcagtggaac acacgaggag aacccctaca gcctgctgga gatctccacg gtagaacggg      420

gtgtggtgag cctcttcggg gtgaagagtg ctctcttcat tgccatgaac agtaaaggaa      480

gactgtacac aacgcccagc ttccacgacg aatgcaagtt ccgagaaacc ctccttccaa      540

acaactacaa cgcctacgag tcagacctgt acagagggac ctacattgca ctgagcaaat      600

atggacgggt aaagcggggc agcaaggtgt ccccaatcat gactgtcact cacttcctcc      660

ccaggatata aggacccatg gatgaaggct cacggggtga cagctgcgtc ttttctgtca      720

ggattttaca ctaagagaac gcttctgctc ctatcccgtg acttctgagt ttggcttatc      780

tcggcctgaa gatctgagtg gatgccctgg gccactggac tgcatggtgt gtaagccacg      840

tggctgaggg tctacagttc acatttcagg atggcagggg ctcctgtgct tcagcctcac      900

ctgaggagag acaatacaga tgactcttgc agcgtgtggc cctgtgcata agaaaaagcc      960

aaaatgggag tatgcatgtg tccgtgcata tccacacatc tattcgtaga ttctcagagc     1020

aaaggcattt taggataccg agttcctttc tcccaacatc gtcaccgcag gaaactgcct     1080

gtcagagcgt cacttgtcga gtcagcagga ttgagatgaa ccccattctg ccgttttctg     1140

atcatctatc tatccagttg tctgtgtaac agtgagcagc tatcttttat gtgccaggag     1200

gaaggtaggg gtataaaata taactgtaaa ct                                   1232


<210> 4
<211> 208
<212> PRT
<213> Mus musculus

<400> 4
Met Ala Leu Gly Gln Arg Leu Phe Ile Thr Met Ser Arg Gly Ala Gly 
1               5                   10                  15      


Arg Val Gln Gly Thr Leu Gln Ala Leu Val Phe Leu Gly Val Leu Val 
            20                  25                  30          


Gly Met Val Val Pro Ser Pro Ala Gly Ala Arg Ala Asn Gly Thr Leu 
        35                  40                  45              


Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly 
    50                  55                  60                  


Leu Ala Gly Glu Ile Ser Gly Val Asn Trp Glu Ser Gly Tyr Leu Val 
65                  70                  75                  80  


Gly Ile Lys Arg Gln Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe 
                85                  90                  95      


His Leu Gln Val Pro Pro Asp Gly Arg Ile Ser Gly Thr His Glu Glu 
            100                 105                 110         


Asn Pro Tyr Ser Leu Leu Glu Ile Ser Thr Val Glu Arg Gly Val Val 
        115                 120                 125             


Ser Leu Phe Gly Val Lys Ser Ala Leu Phe Ile Ala Met Asn Ser Lys 
    130                 135                 140                 


Gly Arg Leu Tyr Thr Thr Pro Ser Phe His Asp Glu Cys Lys Phe Arg 
145                 150                 155                 160 


Glu Thr Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Asp Leu Tyr 
                165                 170                 175     


Arg Gly Thr Tyr Ile Ala Leu Ser Lys Tyr Gly Arg Val Lys Arg Gly 
            180                 185                 190         


Ser Lys Val Ser Pro Ile Met Thr Val Thr His Phe Leu Pro Arg Ile 
        195                 200                 205             


<210> 5
<211> 4545
<212> DNA
<213> Homo sapiens

<400> 5
actctgcgcg ccggcggggg ctgcgcagga ggagcgctcc gcccggctac aacgctccgc       60

gagccggcgc ggcaacacct gttcgcggca gcctgggcgg cacgcgagct cccggacgcg      120

gctctcctcg ctcgccgctc gccacccgtt ctaagccaat ggacatctgc cgagcctctg      180

gagaatcctg gatactagct ttggacgcct aaagtttctt cttctttttg ttttattatt      240

attatcattt tttggagggg ggaccgggag gggagatttg tcgccgccac caacgtgaga      300

tttttttttc cccttgaagg attcatgctg atgtctgcag agtcggttag agagtaaaaa      360

cagcgcatgc cttcctggag tcaggatccg taaattctga cgtagcccgt gcatcttaaa      420

aatccctata ataacgccta ggcatttaag ttgctatggt cattctgatc tcaaaccaaa      480

tggagaaact acggattttt tttccttatt acggtcggat gggatgaaga ccttcctgcc      540

tgctaagagc tggggatcta tctatagaga tacatagata tgtttatcaa tatgtcagtg      600

tgtgagtata aagtggtggt ttcttagact atcagtggtt tgaccttgaa cctgtgccag      660

tgaaacagca gattactttt atttatgcat ttaatggatt gaagaaaaga accttttttt      720

tctctctctc tctgcaactg cagtaaggga ggggagttgg atatacctcg cctaatatct      780

cctgggttga caccatcatt attgtttatt cttgtgctcc aaaagccgag tcctctgatg      840

gctcccttag gtgaagttgg gaactatttc ggtgtgcagg atgcggtacc gtttgggaat      900

gtgcccgtgt tgccggtgga cagcccggtt ttgttaagtg accacctggg tcagtccgaa      960

gcaggggggc tccccagggg acccgcagtc acggacttgg atcatttaaa ggggattctc     1020

aggcggaggc agctatactg caggactgga tttcacttag aaatcttccc caatggtact     1080

atccagggaa ccaggaaaga ccacagccga tttggcattc tggaatttat cagtatagca     1140

gtgggcctgg tcagcattcg aggcgtggac agtggactct acctcgggat gaatgagaag     1200

ggggagctgt atggatcaga aaaactaacc caagagtgtg tattcagaga acagttcgaa     1260

gaaaactggt ataatacgta ctcatcaaac ctatataagc acgtggacac tggaaggcga     1320

tactatgttg cattaaataa agatgggacc ccgagagaag ggactaggac taaacggcac     1380

cagaaattca cacatttttt acctagacca gtggaccccg acaaagtacc tgaactgtat     1440

aaggatattc taagccaaag ttgacaaaga cagtttcttc acttgagccc ttaaaaaagt     1500

aaccactata aaggtttcac gcggtgggtt cttattgatt cgctgtgtca tcacatcagc     1560

tccactgttg ccaaactttg tcgcatgcat aatgtatgat ggaggcttgg atgggaatat     1620

gctgattttg ttctgcactt aaaggcttct cctcctggag ggctgcctag ggccacttgc     1680

ttgatttatc atgagagaag aggagagaga gagagactga gcgctaggag tgtgtgtatg     1740

tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tgtgtgtagc gggagatgtg ggcggagcga     1800

gagcaaaagg actgcggcct gatgcatgct ggaaaaagac acgcttttca tttctgatca     1860

gttgtacttc atcctatatc agcacagctg ccatacttcg acttatcagg attctggctg     1920

gtggcctgcg cgagggtgca gtcttactta aaagactttc agttaattct cactggtatc     1980

atcgcagtga acttaaagca aagacctctt agtaaaaaat aaaaaaaaat aaaaaataaa     2040

aataaaaaaa gttaaattta tttatagaaa ttccaaaggc aacattttat ttattttata     2100

tatttattta ttatatagag tttattttta atgaaacatg tacaggccag ataggcattt     2160

tggaagcttt aggctctgta agcattaaat ggcaaagtcc gctatgaacc tgtggtaaat     2220

tcatgcaagt agatataatg gtgcatggat ataagaaatt ctaatgaccc taatgtacta     2280

aaggcgacaa tctcttttgt gcccatatta ttgtaaactt atgcacatcg ctcatgacac     2340

tgagtattca ctcttcagac tgcttgtttc atagcttatc ccagaggatt aaagataaac     2400

tgggtctcaa actttgattc tgtgtctgca atatttcctc tctcataagt gactccacta     2460

ttgtaacttc atggttggaa aatatgaggg ttgatatatg tcttacttgt ttaaatctgt     2520

cgcagaatat accaaagcta aataataact atgctttcat tttagccgat ctccagaatg     2580

acagtattaa catcaaacat tgtattgatt tagaattctc aaaaaaggaa aaaaaagtac     2640

atagcacaga ctattttttt taaagacgta agaatcagat taacaggatc atacttgtaa     2700

actttttttg gttcacttgg ctatcaaata tgaaattata gaagtatcat aggggtcatt     2760

gtaacatctt ttagagaaaa tggctatcag tgtgaactgt cataattacg tggtaatagc     2820

acccttagta aaacttgcaa aatgaaacta ataaatcgtt atcaataatg acaatgaggg     2880

ggaaagtatt atacttgttg actgtgtttt gttttttaaa atggtctcca caagcgctca     2940

atttttttag aggggatatt actatataga atatctttta caaggctttt ataacatttt     3000

atgctgaaaa gcataagaat acgtatttct ttagtagcaa taattttgga acttgccctt     3060

gggcaagcga gactatttct tactatatac taaggagaaa agagccaaat tcttaaagca     3120

atatttaaga aaaaaggaat ttataacaaa ttctcatcta catatgacac tttctagcca     3180

gttgtgttga gaagtgcaaa gtgacggttt aaacatgtgt tgggatttat tgaactaatt     3240

ttaaaattta ctattcaaac tttattttgc tctgatgcac attctctatg aaaaataaaa     3300

gtgtgtcact ggtgagtgac agctgttatg agctagaagc gcatgactta ttgtgacgat     3360

gtcttgcctt tctgtggtcc aagttggagt acatggcaat gccctcctgc tgatgtgcat     3420

taaggaaaat ctaagtctaa tatttggaat taagatatat tttaggggga ggggacagaa     3480

gcaatgtaaa atagttgatt tatgataaag ctcagaatgt cctcttcatt tattttcttg     3540

ttttattttc ctttctaaac agaaactgca tttaattcca aaaagtagta ttcttattta     3600

ttatttaacc ctttgctgct gctaaaatgt gcacatattc aggctttagt ttttccaaaa     3660

ggcatttttt ttttggctga aaaatattaa acatttgacc acagggaaga atcaagtttc     3720

taggatgtca taggtatact atgtagcact gaaaaaattg attttaggtg acagccaaaa     3780

gtagtcttaa agtagcatga gaccttagat aatcgaccta aaagaaagaa aattgtgaaa     3840

aagacaaaaa tcttcatgca ttcctataaa acgctacttt aaggtctact tttggagtta     3900

attttgtttg gtactttttt tttttttaag acgagcaaat tgttatatgc ttttggcaat     3960

tgatacaata aactgtaatg gtctgtaaat aaataaatat tgactcatgc gatttatgta     4020

aatagtggaa ctgggagagt ggatggctca gggtttcggt gtgggcattg tctcttgggc     4080

agtagagtga gtcatcccca gctcatgggt ttgcatccag ttcttgtctt aagagaccca     4140

aagcccagtg aatggcagcc ctgagccact gtggaatggg ggttctggtt tcacaaacag     4200

atgcttagat agccaaacca ctgtcttgtt ggtgccaaca cttgcactgt ggtcaaagac     4260

ttaccgagca tgggctgaac aaccttccca tctgtcatgt gaatgtcccc aagcagtggt     4320

gaaggacatg ctaggtcagt gttggggaac ctgccctgcc aggtcctgtt ttgtagataa     4380

acaaatggct gccttctggt gtttttattc tatttcatct cattaacact acaaccttgt     4440

gttatttact tgataatctg taattgtatg taaatacata caggattatg taatttgtgt     4500

aaatacataa ttacagagtt ttgaaaactg aaaaaaaaaa aaaaa                     4545


<210> 6
<211> 208
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Pro Leu Gly Glu Val Gly Asn Tyr Phe Gly Val Gln Asp Ala 
1               5                   10                  15      


Val Pro Phe Gly Asn Val Pro Val Leu Pro Val Asp Ser Pro Val Leu 
            20                  25                  30          


Leu Ser Asp His Leu Gly Gln Ser Glu Ala Gly Gly Leu Pro Arg Gly 
        35                  40                  45              


Pro Ala Val Thr Asp Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg 
    50                  55                  60                  


Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly 
65                  70                  75                  80  


Thr Ile Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu 
                85                  90                  95      


Phe Ile Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser 
            100                 105                 110         


Gly Leu Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu 
        115                 120                 125             


Lys Leu Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp 
    130                 135                 140                 


Tyr Asn Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg 
145                 150                 155                 160 


Arg Tyr Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr 
                165                 170                 175     


Arg Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val 
            180                 185                 190         


Asp Pro Asp Lys Val Pro Glu Leu Tyr Lys Asp Ile Leu Ser Gln Ser 
        195                 200                 205             


<210> 7
<211> 4145
<212> DNA
<213> Mus musculus

<400> 7
attctgatct ctaagcaaat ggagaaacta cggatttttt tcccttatta cggtcggatg       60

ggatgaagac ctttctgcct gctgagagtc gaggctccat atgtagcgat gcatagctgt      120

gttgatcaat gtcagtgtgt gagtataaag tggtggcttc ttagactatc agtggtttga      180

ccttgaacct gtgccagaga aacagccgat tacttttatt tatgcatcgg atggattgaa      240

gaaaagaacc ctttttccct ctctgtctgc aactgcggca agggagggga gttggatata      300

cctcgcctag tgtctcctgg ttgataccat cattattgtt tattcttgtg cttaaaagcc      360

gagtcctctg atggctccct taggtgaagt tgggagctat ttcggtgtgc aggacgcggt      420

accgttcggg aacgtaccgg tgttgccggt ggacagtccg gtgttgctaa gtgaccacct      480

gggtcagtcc gaagcagggg ggctgccccg gggccccgca gtcacggact tggatcattt      540

aaaggggatt ctcaggcgga ggcagctgta ctgcaggact ggatttcatt tagagatctt      600

ccccaacggt actatccagg gaaccaggaa agaccacagc cgcttcggca ttctggaatt      660

tatcagtata gcagtgggcc tggtcagcat tcgcggtgtg gacagtggac tctacctcgg      720

catgaacgag aagggggagc tgtatggatc agaaaaacta acacaggaat gtgtgttcag      780

agaacagttt gaagagaact ggtacaacac ctactcttcc aacctctata aacatgtgga      840

caccggaagg agatactatg ttgcattaaa taaggacggg actccaagag aagggaccag      900

gactaaacgg caccagaaat ttacacattt tttacctaga ccagtggacc ctgacaaagt      960

acctgaacta tataaggata ttctaagcca aagctgacaa agacagtgtc ttcacttgag     1020

cccttaaaac ataaccacta taaatgcttt catgcggtgg gttcttattg attagcagtg     1080

ccgtcacctc agctccactg ttgccaaact ttgtcgcatg catatgaatg atggaagctt     1140

ggatgaggac ttgccaattt gctctgcact tactggctgg tcctcctgga gggctgccta     1200

gggccacttg cttgatttat tacaaaagca ggggagagag gctgcgggag agggtgcgag     1260

tgcatgagtg agtggagggg actgcagcgc gccacgagga caatggcctg atgcatgctg     1320

ggaaatagac acgcttttac atttttgatc agttgaactt cattctatat cagcacagct     1380

gccatacttc aactcatcag gatttttggc tggtggcctg ctcaagggaa cactgccttt     1440

ccacaggcgt ggagagagca gtctcactta aaaagactat cagttcattc acactggtat     1500

catagcccag tgaatttaaa gcaaagacct cttagtttaa aagaaaaaaa aaaaaagaaa     1560

gaaaaaaaag aaaagaaaaa gaaaaaaaca aggaaaaaaa gaaaaaaaag aaaaaaggtt     1620

aaatttattt atagaaattc caaaggcaac attttattta ttttatatat ttatttatta     1680

tatagagttt atttttaatg aaatatgtac aggccagata ggcattttgg aagctttagg     1740

ctctgtaggc attaaatggc aaagtctgct atgaacctgt ggtaacttca tgcaagtagg     1800

tatacgagaa attctaatgg ccctaatgta ctaaaggcga caatctattt tgtgcccata     1860

ttattgtaaa cttctgcaca tcgctcatga cactgaggag tcactcttca gactgcttgt     1920

ttcatagctt atcccagagg attaaagata aactgggttt caacccttca tttcgtgtct     1980

gtaattttcc tctctcgtaa ttcagtctct cagtgtaact gggcggttgg aacatatgag     2040

ggttggtgta tgtcttactt gttttaatct attgcagagt gtaccaaagc taagcaatga     2100

ctatgcgttt taaatttcag cccacttctg tgacaacagg gctaacatca aacatggcac     2160

tgattaaaaa ttcccaaggg agaggaaaat ccatttacat agctcctcct cctcttcctc     2220

cgcctcttcc tcctcttcct cttcgacttc ctcggcctcc tcttcttttc tttcttttct     2280

tttcttttct tttcttttct tttcttttct tttcttttct tttcttttct tttcttttct     2340

tttcttttct tttctttctt ttcttttctt ttctcttctc ttctcttctc ttcttttctt     2400

ttcttttctt ttcttttctt ttctttcctt ttcttttctt ttctgaggca aaaattagat     2460

gaccgggatc attcttgtaa acattttatt tgtgtcttgg ctatcaaata tgaaattcta     2520

catggaccct agggctcact ataacatttt taatggagct ggcatttggt gtgaactgtc     2580

ataatcacat ggggttagta acctccaagt taaactggca acatggaact aatgtcttca     2640

tcagtaacga ccttggaggg gttactgtag ccattgcctg tgcttcatct ccgaatcgga     2700

cttcagcagt tctcagagaa gtgggtacta aatagaacac tgtttacaaa accttttata     2760

acattatatg ctgaaaagcc caagaataca tacttatttg atagccaaaa tcctcctgtt     2820

gggtaaggga gactatttct ctctcactat ataccaaggt gaaaagagcc aagttcttga     2880

agcaataaag aaatctataa cacattctca ctctctagct cgttgatgtg gggaaattga     2940

aagtgacagc taaaaaaata tgtttgaatt tgtgcagcta attttaagat gcaatattct     3000

ggcttcactt tgcttggatg cacattctcg atgggaagcg aaagcgtgtc actggcaagg     3060

gatagctgtt gtggtctaga aatgcctgtc ttcctgtcct gagcaaatcc atgtagccat     3120

cttatggtcc aagctggagc gggtgacgat cttccgtgct gatgagcatt agggaggaac     3180

ttgtatttgg aactgagaga tgtcacagag agaggagcca gacgctctgt ggatcaggca     3240

ataggataaa gatcaggatg cattctgcat gtgtgttctg tggatccccc acccgctttc     3300

taaacaggag ccggcgtgaa ttttgagcag tgtttttgtt tgttatttaa cactttgctg     3360

ctaaaatgta cacatactca gatttccatt tatccaaaag cacttatttt attttatttt     3420

gctgcaaaag attcaacatt tggccatagg aaagaattag gttggtagga tgtcatagct     3480

gtaatatctg aagaaattga ttttaggaga cagccaataa taatcataaa gtagcaggtg     3540

ttccagaaaa tcagcccaga agaataaaaa agaactgtgc agaaactaaa aatttcatat     3600

attcccagaa aatgctactt taatgtctct ttttggactt tgttttggta cttttttttt     3660

ttttttttcc tttctgaaaa gcaaaatgtt gtctgctttt ggtaaccagt acaataaact     3720

gtaatggtct gtaaataaat aaatattgat gtatgctatt tatgtaaata ggcattctgg     3780

gagggaagat ggctcagggt ttctgtgtat caccctggga agtggatgga ttctttccag     3840

ctctccggtt tgcatcaggt tcagttcctg ctttaagagg cacaaagcct gttggatggc     3900

agccccatgc cactgtgggc tgggtgattc cagctcagaa gcagatgctc agatagccaa     3960

accactctct cgttggtgcc aacactggca tcctggtcaa agtcttagcc agggtggact     4020

gaaccacctt cccatctgtc atgcaaatgt ccccaagcag tgttgaagga catgccaggt     4080

cagtgttgga acctgccctg ccaggtcctg ttttgtagat taaaaaaaaa atggcttcaa     4140

aaaaa                                                                 4145


<210> 8
<211> 208
<212> PRT
<213> Mus musculus

<400> 8
Met Ala Pro Leu Gly Glu Val Gly Ser Tyr Phe Gly Val Gln Asp Ala 
1               5                   10                  15      


Val Pro Phe Gly Asn Val Pro Val Leu Pro Val Asp Ser Pro Val Leu 
            20                  25                  30          


Leu Ser Asp His Leu Gly Gln Ser Glu Ala Gly Gly Leu Pro Arg Gly 
        35                  40                  45              


Pro Ala Val Thr Asp Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg 
    50                  55                  60                  


Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly 
65                  70                  75                  80  


Thr Ile Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu 
                85                  90                  95      


Phe Ile Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser 
            100                 105                 110         


Gly Leu Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu 
        115                 120                 125             


Lys Leu Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp 
    130                 135                 140                 


Tyr Asn Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg 
145                 150                 155                 160 


Arg Tyr Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr 
                165                 170                 175     


Arg Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val 
            180                 185                 190         


Asp Pro Asp Lys Val Pro Glu Leu Tyr Lys Asp Ile Leu Ser Gln Ser 
        195                 200                 205             


<210> 9
<211> 4162
<212> DNA
<213> Homo sapiens

<400> 9
agaagtccat tcggctcaca catttgcccc aagacaaacc acgttaaaat aacacccagg       60

gtagctgctg ccaccgtctt ctgtctctac ctccctcctg gctggccaat ggctctgtgt      120

tcctgggcct gctgctggct gtccagagta ggggttgctt agagctgtgt gcatccctgc      180

gggtggtgtg ggagtgggcg gttgtctaaa ggcaggtccc ctctactgat aaacaaggac      240

cggagataga cctagaggct gacattcttg gctcccccag cctacacccc ccccacctcg      300

atttcccaca gagccctagg gacgggtagc cagctctgtg gcatggtatc tggaggcagg      360

ccagcaacct gatgtgcatg ccacggcccg tccctctccc cactcagagc tgcagtagcc      420

tggaggttca gagagccggg ctactctgag aagaagacac caagtggatt ctgcttcccc      480

tgggacagca ctgagcgagt gtggagagag gtacagccct cggcctacaa gctctttagt      540

cttgaaagcg ccacaagcag cagctgctga gccatggctg aaggggaaat caccaccttc      600

acagccctga ccgagaagtt taatctgcct ccagggaatt acaagaagcc caaactcctc      660

tactgtagca acgggggcca cttcctgagg atccttccgg atggcacagt ggatgggaca      720

agggacagga gcgaccagca cattcagctg cagctcagtg cggaaagcgt gggggaggtg      780

tatataaaga gtaccgagac tggccagtac ttggccatgg acaccgacgg gcttttatac      840

ggctcacaga caccaaatga ggaatgtttg ttcctggaaa ggctggagga gaaccattac      900

aacacctata tatccaagaa gcatgcagag aagaattggt ttgttggcct caagaagaat      960

gggagctgca aacgcggtcc tcggactcac tatggccaga aagcaatctt gtttctcccc     1020

ctgccagtct cttctgatta aagagatctg ttctgggtgt tgaccactcc agagaagttt     1080

cgaggggtcc tcacctggtt gacccaaaaa tgttcccttg accattggct gcgctaaccc     1140

ccagcccaca gagcctgaat ttgtaagcaa cttgcttcta aatgcccagt tcacttcttt     1200

gcagagcctt ttacccctgc acagtttaga acagagggac caaattgctt ctaggagtca     1260

actggctggc cagtctgggt ctgggtttgg atctccaatt gcctcttgca ggctgagtcc     1320

ctccatgcaa aagtggggct aaatgaagtg tgttaagggg tcggctaagt gggacattag     1380

taactgcaca ctatttccct ctactgagta aaccctatct gtgattcccc caaacatctg     1440

gcatggctcc cttttgtcct tcctgtgccc tgcaaatatt agcaaagaag cttcatgcca     1500

ggttaggaag gcagcattcc atgaccagaa acagggacaa agaaatcccc ccttcagaac     1560

agaggcattt aaaatggaaa agagagattg gattttggtg ggtaacttag aaggatggca     1620

tctccatgta gaataaatga agaaagggag gcccagccgc aggaaggcag aataaatcct     1680

tgggagtcat taccacgcct tgaccttccc aaggttactc agcagcagag agccctgggt     1740

gacttcaggt ggagagcact agaagtggtt tcctgataac aagcaaggat atcagagctg     1800

ggaaattcat gtggatctgg ggactgagtg tgggagtgca gagaaagaaa gggaaactgg     1860

ctgaggggat accataaaaa gaggatgatt tcagaaggag aaggaaaaag aaagtaatgc     1920

cacacattgt gcttggcccc tggtaagcag aggctttggg gtcctagccc agtgcttctc     1980

caacactgaa gtgcttgcag atcatctggg gacctggttt gaatggagat tctgattcag     2040

tgggttgggg gcagagtttc tgcagttcca tcaggtcccc cccaggtgca ggtgctgaca     2100

atactgctgc cttacccgcc atacattaag gagcagggtc ctggtcctaa agagttattc     2160

aaatgaaggt ggttcgacgc cccgaacctc acctgacctc aactaaccct taaaaatgca     2220

cacctcatga gtctacctga gcattcaggc agcactgaca atagttatgc ctgtactaag     2280

gagcatgatt ttaagaggct ttggcccaat gcctataaaa tgcccatttc gaagatatac     2340

aaaaacatac ttcaaaaatg ttaaaccctt accaacagct tttcccagga gaccatttgt     2400

attaccatta cttgtataaa tacacttcct gcttaaactt gacccaggtg gctagcaaat     2460

tagaaacacc attcatctct aacatatgat actgatgcca tgtaaaggcc tttaataagt     2520

cattgaaatt tactgtgaga ctgtatgttt taattgcatt taaaaatata tagcttgaaa     2580

gcagttaaac tgattagtat tcaggcactg agaatgatag taataggata caatgtataa     2640

gctactcact tatctgatac ttatttacct ataaaatgag atttttgttt tccactgtgc     2700

tattacaaat tttcttttga aagtaggaac tcttaagcaa tggtaattgt gaataaaaat     2760

tgatgagagt gttagctcct gtttcatatg aaattgaagt aattgttaac taaaaacaat     2820

tccttagtaa ctgaactgtc atatttagaa tggaaggaaa atgacagttt gtgaaagttc     2880

aaagcaatag tgcaattgaa gaattgacct aagtaagctg acattatggt taataatagt     2940

attttagatt tgtgcagcaa aataatttca taactttttt gtttttgtta cttggataag     3000

atcaatctgt tttattttag taaatctttg caggcaagtt agagaaaatg cagtgtggct     3060

taacgtctct ttagtatgaa gatttggcca gaaaaagata cccagagagg aaatctaaga     3120

taattataat ggtccatact ttttattgta tgaatcaaac tcaagcataa cattggccaa     3180

ggaaaattaa ataccattgc taacttgtga aatggaagtc tgtgatttcg gagatgcaaa     3240

gcattgtagt aaaaacacca atgtgacctc gaccatctca gcccagatat cattcatata     3300

tctgttcaat gactattaag gtgcctactg tgtgctaggc actgtactgg atactgggga     3360

ccttgtctgt ctggtttgct gctgtatctt ctcccagggc attatattta tgatgaaaga     3420

tgctgtggat tcaattcttt cagtcaagaa taaacacaga ctttgtaggt tcctgctgaa     3480

taaagcaaat cccagaaacc cagattttgg aagaatcagc aaccccagca taaaataaac     3540

ccctatcaaa atgtcagagg acatggcaag gtaaacttag cattttcaac tttagaaccg     3600

ggtcagcttc agggggactg ctttcaaatc agccaaagag cctgtcagat cttcttagaa     3660

ggaagaggtt ggtagttccc tgctctgttt tgaacatgct ctagtttatt aacctgggga     3720

cattcccatt gctgtcttaa gtaagtctca tagccagctc ctgtcacgtg actctcatat     3780

ggattcattt tcgggccagc tctgaacaaa gcatcatgaa catatgtgct tttggtcgtt     3840

tgcaatgtga tggtggtgga ggtaggtatt ggtttccttg gaaggcatga taagaaagat     3900

tcacaatggc caacagtgtg tatgaacaaa aaactgattg gagcatcagc tagtactgaa     3960

ggtccttgct ttgtgtcaga ggcaaaggaa cccaaggcgc caagtcctca gccttgagtg     4020

tactgctgac aactaaactc acaggctgca aagcagacct ctgatgaaga tgcctgttat     4080

ttcacatcac tgtctttttg tgtatcatag tctgcacctt acaaatatta ataaatgttc     4140

caataatagg tgaaaaaaaa aa                                              4162


<210> 10
<211> 155
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210> 11
<211> 3909
<212> DNA
<213> Mus musculus

<400> 11
agagctgcag aaatcctgag gctcagagag ccggctggag aggcagcttc agtccaggca       60

ccctgtgaca gcgcaaaggc tgcccagcgg acttcattcc cgtcttgtga taaagtggag      120

tgaagagagc cccccagcct gccagttctt cagtgctgag cctaccaccg ctgcttgctg      180

ccgagccatg gctgaagggg agatcacaac cttcgcagcc ctgaccgaga ggttcaacct      240

gcctctagga aactacaaaa agcccaaact gctctactgc agcaacgggg gccacttctt      300

gaggatcctt cctgatggca ccgtggatgg gacaagggac aggagcgacc agcacattca      360

gctgcagctc agtgcggaaa gtgcgggcga agtgtatata aagggtacgg agaccggcca      420

gtacttggcc atggacaccg aagggctttt atacggctcg cagacaccaa atgaggaatg      480

tctgttcctg gaaaggctgg aagaaaacca ttataacact tacacctcca agaagcatgc      540

ggagaagaac tggtttgtgg gcctcaagaa gaacgggagc tgtaagcgcg gtcctcggac      600

tcactatggc cagaaagcca tcttgtttct gcccctcccg gtgtcttctg actagaggag      660

tctgttctga gtgttctcta ttttggttga ccctaccatg ttcccttgac cattggctgc      720

gctaaccctc aggccacaga gcctgaattt gtaagcagtg cttctaaaat agccagttca      780

cttttctgct gagcccttcc ccaccacccc agcacaattt ggaacacagg gaccaaattg      840

cttcaagagg acaactggct ggccagtcta ggtctgggtt tggatatccg gatgcctcag      900

ggcacctgct acaagctgga cctggtgatg caaagttggg ggccatacga agcattcaaa      960

ggggtctaag aagtgggttc ttagaaagat acccactgca tgctctttcc ccttctgagc     1020

aatccctggt tttaagcacc ccaggcaatt agcatgacta cccttccccc taccagaacc     1080

gcacaaatat cagtaaagca accggtagtg aggctgaagg aatttcatgg tagagagaac     1140

cccccccccc cagcccccac atatggacaa gacttaaaac caaaagggag tgtggcgttt     1200

ccgggacagc ctagaagcat gggatctcgg aacagagtaa gaaggcaaga gtcagccaca     1260

gggagtcagg atgagcccac agcccagcag ttatcaccaa gttaccaagg aaacgtccac     1320

agtcagggaa agagccccgg aaatggtttc ttagtaatgg caagcacaga gatctggggt     1380

ctgaagagtg ggcgtaggag caaggagaca ggatgtcttc agccgtggat gttagcctct     1440

aaaaaggaag atgttagacg ggaggaggag gagagaaaaa gtaatatcac gtcactgtgt     1500

gcttggccac cacgaaactg gggttgtggg ggtcccagta cgatggcccc aaatagccca     1560

tacattcaga tcatctgtat tcagattcat ttgtatgact gtgaaacctg atttggtggg     1620

gctggtgtgg gggaggtctg tgtcttgaaa ggcccgcaag tcccatagat gctgctggct     1680

tccccaccat gctttcaaga gcagccccag agaatgctgt tcaaatgaag gttgctcaga     1740

cttcaccctc ttttacctcc agtgcccggg ttttcctgag tatccatcca ggcagtgtcc     1800

atagttagtg aagcatggtt tcaaggcacc ttggcccagt gcctataaaa tgcccactca     1860

gaaatcactg aaaccgtact tcaaaaaaaa atgttgaacc tcaccaaaag ctttctccca     1920

agagaccatt tctgttacca ttaattcttc aaactggctt cctccttaaa gtaaacctgg     1980

cccaagtgcc cagcaaatta gaaacactat tcatctctga cataggacac aaacgccatg     2040

agaaggcctt tcatacgcca atttaatata ctgtgagact tatcttctcg ttgcttctta     2100

tatagcttga aggcattaaa tagattcaca atcagccaca gaggataata acagcctaga     2160

atgtaaaagc tacttagtta tctaacatgc tacattcatt catgaggcct ttcctctttg     2220

tcttccactg tgctttaaga atgggtatct aggggctggt gagatgggac aggagttcag     2280

ttcctagcat tcacagtgtg atgctcagac ccaattctaa ctccaactcc aggggtactg     2340

catacacatg tacaaaccca cactttttca gaaatataaa ccaataatat ggttgtggat     2400

taaaactgat gactgtgttc atttgtttga cagggatcta aagtcattat ttgctggaaa     2460

aaaatcctta tagcaacact gtcatatctt agcacagaag tcagatgaca ctcttgagag     2520

ttcagagtgc taatggggga actaaaccga gctatttcaa tacatgatta ataataatgt     2580

tctttcagat gtggggatga acacctttaa tcccagcact caggaggcag aggcaggtag     2640

atctatgtaa gactgaggct aacctggtct ccacagtgag ttcctgggca gccaggggta     2700

tatagaaagg ccccgtatct tttttttttt taatcataat aatgttttgc ttttttacaa     2760

aaagatgatt catggctttt taaagtctat aacttaaata tgtttctgtt ttgtttcagt     2820

aaatcgtagg cacactggag ataatacagt atggtttccc atgtctttat ataaagattt     2880

ggcccagaaa agtgtacaga gatgaaatct aggatattta gaatagtggg tagtttttta     2940

tcaaatgaac ccaaacacaa gtataaccct gatcaagaca aattaaaaac cactgcacaa     3000

ggatgaaatg aagtctgaga ccccagagac tcaaagcact gatgatggtc attgtagcct     3060

taaccgtcaa cctagtcacc atccgggtat ttgctcaaca tatactgcag acccaatgtg     3120

tgtcaggcac tggatatggc ccctggggac aatgtctgtc agctgtcctc tctctgggca     3180

tatatttgtc aagagagatg ctatggattc atttccttca gtcacgtcaa aacatggact     3240

tcatagtttc ctactgaatc aacagtatgt tctagaaacc ctcaacggtc agtcacacca     3300

ccccaccccc aacaaagtga cagagacagg ctttgccaag taaacccagg gctttcaatg     3360

ttagtcctct cagaggagtg gagtagtttc aaatcaggaa ggaaaaaaca aacaaaaaag     3420

ctgtcggatc ttgcagaaag ggagcagaga gactgtccct gtgctggtgg gagcactgat     3480

cataggaaca ttcggttgtg tacgaagtcc caagaccatc tgcttgtcac atgcctcctg     3540

tatgcactca attccaagct gactgcaacc tggtgtctaa cactcactac gaactgtgag     3600

gagcatatgg gcttttgaca attagtgaca cagtagatat ggagctgggt gtatcccctg     3660

atggccagca gtgtgcccct acagaaatcc taactggtac atcagctgcc attgaagacg     3720

aggcccctgc tttgtgttga aggcagtgga gcccgagtcc tcagctctgc agagaacacc     3780

gcctaaaagc aatcacggtc gctggctgca aagcaggctc tgatggagac gacgcctgac     3840

attcactctg cacccatact gtattacact ctgcacctta tcaatattaa taaatgttgt     3900

attaatggc                                                             3909


<210> 12
<211> 155
<212> PRT
<213> Mus musculus

<400> 12
Met Ala Glu Gly Glu Ile Thr Thr Phe Ala Ala Leu Thr Glu Arg Phe 
1               5                   10                  15      


Asn Leu Pro Leu Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Ala Gly Glu Val Tyr Ile Lys Gly Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Glu Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Thr Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210> 13
<211> 6774
<212> DNA
<213> Homo sapiens

<400> 13
cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc       60

gcgggaggct ggtgggtgtg gggggtggag atgtagaaga tgtgacgccg cggcccggcg      120

ggtgccagat tagcggacgc ggtgcccgcg gttgcaacgg gatcccgggc gctgcagctt      180

gggaggcggc tctccccagg cggcgtccgc ggagacaccc atccgtgaac cccaggtccc      240

gggccgccgg ctcgccgcgc accaggggcc ggcggacaga agagcggccg agcggctcga      300

ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg ggccggggcc      360

ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg gcggctcccc      420

gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg gcagccggga      480

gcatcaccac gctgcccgcc ttgcccgagg atggcggcag cggcgccttc ccgcccggcc      540

acttcaagga ccccaagcgg ctgtactgca aaaacggggg cttcttcctg cgcatccacc      600

ccgacggccg agttgacggg gtccgggaga agagcgaccc tcacatcaag ctacaacttc      660

aagcagaaga gagaggagtt gtgtctatca aaggagtgtg tgctaaccgt tacctggcta      720

tgaaggaaga tggaagatta ctggcttcta aatgtgttac ggatgagtgt ttcttttttg      780

aacgattgga atctaataac tacaatactt accggtcaag gaaatacacc agttggtatg      840

tggcactgaa acgaactggg cagtataaac ttggatccaa aacaggacct gggcagaaag      900

ctatactttt tcttccaatg tctgctaaga gctgatttta atggccacat ctaatctcat      960

ttcacatgaa agaagaagta tattttagaa atttgttaat gagagtaaaa gaaaataaat     1020

gtgtatagct cagtttggat aattggtcaa acaatttttt atccagtagt aaaatatgta     1080

accattgtcc cagtaaagaa aaataacaaa agttgtaaaa tgtatattct cccttttata     1140

ttgcatctgc tgttacccag tgaagcttac ctagagcaat gatctttttc acgcatttgc     1200

tttattcgaa aagaggcttt taaaatgtgc atgtttagaa acaaaatttc ttcatggaaa     1260

tcatatacat tagaaaatca cagtcagatg tttaatcaat ccaaaatgtc cactatttct     1320

tatgtcattc gttagtctac atgtttctaa acatataaat gtgaatttaa tcaattcctt     1380

tcatagtttt ataattctct ggcagttcct tatgatagag tttataaaac agtcctgtgt     1440

aaactgctgg aagttcttcc acagtcaggt caattttgtc aaacccttct ctgtacccat     1500

acagcagcag cctagcaact ctgctggtga tgggagttgt attttcagtc ttcgccaggt     1560

cattgagatc catccactca catcttaagc attcttcctg gcaaaaattt atggtgaatg     1620

aatatggctt taggcggcag atgatataca tatctgactt cccaaaagct ccaggatttg     1680

tgtgctgttg ccgaatactc aggacggacc tgaattctga ttttatacca gtctcttcaa     1740

aaacttctcg aaccgctgtg tctcctacgt aaaaaaagag atgtacaaat caataataat     1800

tacactttta gaaactgtat catcaaagat tttcagttaa agtagcatta tgtaaaggct     1860

caaaacatta ccctaacaaa gtaaagtttt caatacaaat tctttgcctt gtggatatca     1920

agaaatccca aaatattttc ttaccactgt aaattcaaga agcttttgaa atgctgaata     1980

tttctttggc tgctacttgg aggcttatct acctgtacat ttttggggtc agctcttttt     2040

aacttcttgc tgctcttttt cccaaaaggt aaaaatatag attgaaaagt taaaacattt     2100

tgcatggctg cagttccttt gtttcttgag ataagattcc aaagaactta gattcatttc     2160

ttcaacaccg aaatgctgga ggtgtttgat cagttttcaa gaaacttgga atataaataa     2220

ttttataatt caacaaaggt tttcacattt tataaggttg atttttcaat taaatgcaaa     2280

tttgtgtggc aggattttta ttgccattaa catatttttg tggctgcttt ttctacacat     2340

ccagatggtc cctctaactg ggctttctct aattttgtga tgttctgtca ttgtctccca     2400

aagtatttag gagaagccct ttaaaaagct gccttcctct accactttgc tggaaagctt     2460

cacaattgtc acagacaaag atttttgttc caatactcgt tttgcctcta tttttcttgt     2520

ttgtcaaata gtaaatgata tttgcccttg cagtaattct actggtgaaa aacatgcaaa     2580

gaagaggaag tcacagaaac atgtctcaat tcccatgtgc tgtgactgta gactgtctta     2640

ccatagactg tcttacccat cccctggata tgctcttgtt ttttccctct aatagctatg     2700

gaaagatgca tagaaagagt ataatgtttt aaaacataag gcattcgtct gccatttttc     2760

aattacatgc tgacttccct tacaattgag atttgcccat aggttaaaca tggttagaaa     2820

caactgaaag cataaaagaa aaatctaggc cgggtgcagt ggctcatgcc tatattccct     2880

gcactttggg aggccaaagc aggaggatcg cttgagccca ggagttcaag accaacctgg     2940

tgaaaccccg tctctacaaa aaaacacaaa aaatagccag gcatggtggc gtgtacatgt     3000

ggtctcagat acttgggagg ctgaggtggg agggttgatc acttgaggct gagaggtcaa     3060

ggttgcagtg agccataatc gtgccactgc agtccagcct aggcaacaga gtgagacttt     3120

gtctcaaaaa aagagaaatt ttccttaata agaaaagtaa tttttactct gatgtgcaat     3180

acatttgtta ttaaatttat tatttaagat ggtagcacta gtcttaaatt gtataaaata     3240

tcccctaaca tgtttaaatg tccattttta ttcattatgc tttgaaaaat aattatgggg     3300

aaatacatgt ttgttattaa atttattatt aaagatagta gcactagtct taaatttgat     3360

ataacatctc ctaacttgtt taaatgtcca tttttattct ttatgtttga aaataaatta     3420

tggggatcct atttagctct tagtaccact aatcaaaagt tcggcatgta gctcatgatc     3480

tatgctgttt ctatgtcgtg gaagcaccgg atgggggtag tgagcaaatc tgccctgctc     3540

agcagtcacc atagcagctg actgaaaatc agcactgcct gagtagtttt gatcagttta     3600

acttgaatca ctaactgact gaaaattgaa tgggcaaata agtgcttttg tctccagagt     3660

atgcgggaga cccttccacc tcaagatgga tatttcttcc ccaaggattt caagatgaat     3720

tgaaattttt aatcaagata gtgtgcttta ttctgttgta ttttttatta ttttaatata     3780

ctgtaagcca aactgaaata acatttgctg ttttataggt ttgaagaaca taggaaaaac     3840

taagaggttt tgtttttatt tttgctgatg aagagatatg tttaaatatg ttgtattgtt     3900

ttgtttagtt acaggacaat aatgaaatgg agtttatatt tgttatttct attttgttat     3960

atttaataat agaattagat tgaaataaaa tataatggga aataatctgc agaatgtggg     4020

ttttcctggt gtttccctct gactctagtg cactgatgat ctctgataag gctcagctgc     4080

tttatagttc tctggctaat gcagcagata ctcttcctgc cagtggtaat acgatttttt     4140

aagaaggcag tttgtcaatt ttaatcttgt ggataccttt atactcttag ggtattattt     4200

tatacaaaag ccttgaggat tgcattctat tttctatatg accctcttga tatttaaaaa     4260

acactatgga taacaattct tcatttacct agtattatga aagaatgaag gagttcaaac     4320

aaatgtgttt cccagttaac tagggtttac tgtttgagcc aatataaatg tttaactgtt     4380

tgtgatggca gtattcctaa agtacattgc atgttttcct aaatacagag tttaaataat     4440

ttcagtaatt cttagatgat tcagcttcat cattaagaat atcttttgtt ttatgttgag     4500

ttagaaatgc cttcatatag acatagtctt tcagacctct actgtcagtt ttcatttcta     4560

gctgctttca gggttttatg aattttcagg caaagcttta atttatacta agcttaggaa     4620

gtatggctaa tgccaacggc agtttttttc ttcttaattc cacatgactg aggcatatat     4680

gatctctggg taggtgagtt gttgtgacaa ccacaagcac tttttttttt tttaaagaaa     4740

aaaaggtagt gaatttttaa tcatctggac tttaagaagg attctggagt atacttaggc     4800

ctgaaattat atatatttgg cttggaaatg tgtttttctt caattacatc tacaagtaag     4860

tacagctgaa attcagagga cccataagag ttcacatgaa aaaaatcaat ttatttgaaa     4920

aggcaagatg caggagagag gaagccttgc aaacctgcag actgcttttt gcccaatata     4980

gattgggtaa ggctgcaaaa cataagctta attagctcac atgctctgct ctcacgtggc     5040

accagtggat agtgtgagag aattaggctg tagaacaaat ggccttctct ttcagcattc     5100

acaccactac aaaatcatct tttatatcaa cagaagaata agcataaact aagcaaaagg     5160

tcaataagta cctgaaacca agattggcta gagatatatc ttaatgcaat ccattttctg     5220

atggattgtt acgagttggc tatataatgt atgtatggta ttttgatttg tgtaaaagtt     5280

ttaaaaatca agctttaagt acatggacat ttttaaataa aatatttaaa gacaatttag     5340

aaaattgcct taatatcatt gttggctaaa tagaataggg gacatgcata ttaaggaaaa     5400

ggtcatggag aaataatatt ggtatcaaac aaatacattg atttgtcatg atacacattg     5460

aatttgatcc aatagtttaa ggaataggta ggaaaatttg gtttctattt ttcgatttcc     5520

tgtaaatcag tgacataaat aattcttagc ttattttata tttccttgtc ttaaatactg     5580

agctcagtaa gttgtgttag gggattattt ctcagttgag actttcttat atgacatttt     5640

actatgtttt gacttcctga ctattaaaaa taaatagtag atacaatttt cataaagtga     5700

agaattatat aatcactgct ttataactga ctttattata tttatttcaa agttcattta     5760

aaggctacta ttcatcctct gtgatggaat ggtcaggaat ttgttttctc atagtttaat     5820

tccaacaaca atattagtcg tatccaaaat aacctttaat gctaaacttt actgatgtat     5880

atccaaagct tctcattttc agacagatta atccagaagc agtcataaac agaagaatag     5940

gtggtatgtt cctaatgata ttatttctac taatggaata aactgtaata ttagaaatta     6000

tgctgctaat tatatcagct ctgaggtaat ttctgaaatg ttcagactca gtcggaacaa     6060

attggaaaat ttaaattttt attcttagct ataaagcaag aaagtaaaca cattaatttc     6120

ctcaacattt ttaagccaat taaaaatata aaagatacac accaatatct tcttcaggct     6180

ctgacaggcc tcctggaaac ttccacatat ttttcaactg cagtataaag tcagaaaata     6240

aagttaacat aactttcact aacacacaca tatgtagatt tcacaaaatc cacctataat     6300

tggtcaaagt ggttgagaat atatttttta gtaattgcat gcaaaatttt tctagcttcc     6360

atcctttctc cctcgtttct tctttttttg ggggagctgg taactgatga aatcttttcc     6420

caccttttct cttcaggaaa tataagtggt tttgtttggt taacgtgata cattctgtat     6480

gaatgaaaca ttggagggaa acatctactg aatttctgta atttaaaata ttttgctgct     6540

agttaactat gaacagatag aagaatctta cagatgctgc tataaataag tagaaaatat     6600

aaatttcatc actaaaatat gctattttaa aatctatttc ctatattgta tttctaatca     6660

gatgtattac tcttattatt tctattgtat gtgttaatga ttttatgtaa aaatgtaatt     6720

gcttttcatg agtagtatga ataaaattga ttagtttgtg ttttcttgtc tccc           6774


<210> 14
<211> 288
<212> PRT
<213> Homo sapiens

<400> 14
Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210> 15
<211> 695
<212> DNA
<213> Mus musculus

<400> 15
ggccccgggc cgttgtacac tcaaggggct ctctcggctt caggaagagt ccggctgcac       60

tgggctggga gcccggcggg acacggactg ggaggctggc agcccgcggg cgagccgcgc      120

tggggggccg aggccggggt cggggccggg gagccccaag agctgccaca gcggggtccc      180

ggggccgcgg aagggccatg gctgccagcg gcatcacctc gcttcccgca ctgccggagg      240

acggcggcgc cgccttccca ccaggccact tcaaggaccc caagcggctc tactgcaaga      300

acggcggctt cttcctgcgc atccatcccg acggccgcgt ggatggcgtc cgcgagaaga      360

gcgacccaca cgtcaaacta caactccaag cagaagagag aggagttgtg tctatcaagg      420

gagtgtgtgc caaccggtac cttgctatga aggaagatgg acggctgctg gcttctaagt      480

gtgttacaga agagtgtttc ttctttgaac gactggaatc taataactac aatacttacc      540

ggtcacggaa atactccagt tggtatgtgg cactgaaacg aactgggcag tataaactcg      600

gatccaaaac gggacctgga cagaaggcca tactgtttct tccaatgtct gctaagagct      660

gactcacttt tgacactgtc actgagacac tgtca                                 695


<210> 16
<211> 154
<212> PRT
<213> Mus musculus

<400> 16
Met Ala Ala Ser Gly Ile Thr Ser Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ala Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu Tyr 
            20                  25                  30          


Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val 
        35                  40                  45              


Asp Gly Val Arg Glu Lys Ser Asp Pro His Val Lys Leu Gln Leu Gln 
    50                  55                  60                  


Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn Arg 
65                  70                  75                  80  


Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys Val 
                85                  90                  95      


Thr Glu Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn 
            100                 105                 110         


Thr Tyr Arg Ser Arg Lys Tyr Ser Ser Trp Tyr Val Ala Leu Lys Arg 
        115                 120                 125             


Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 


<210> 17
<211> 1220
<212> DNA
<213> Homo sapiens

<400> 17
gggagcgggc gagtaggagg gggcgccggg ctatatatat agcggctcgg cctcgggcgg       60

gcctggcgct cagggaggcg cgcactgctc ctcagagtcc cagctccagc cgcgcgcttt      120

ccgcccggct cgccgctcca tgcagccggg gtagagcccg gcgcccgggg gccccgtcgc      180

ttgcctcccg cacctcctcg gttgcgcact cctgcccgag gtcggccgtg cgctcccgcg      240

ggacgccaca ggcgcagctc tgccccccag cttcccgggc gcactgaccg cctgaccgac      300

gcacggccct cgggccggga tgtcggggcc cgggacggcc gcggtagcgc tgctcccggc      360

ggtcctgctg gccttgctgg cgccctgggc gggccgaggg ggcgccgccg cacccactgc      420

acccaacggc acgctggagg ccgagctgga gcgccgctgg gagagcctgg tggcgctctc      480

gttggcgcgc ctgccggtgg cagcgcagcc caaggaggcg gccgtccaga gcggcgccgg      540

cgactacctg ctgggcatca agcggctgcg gcggctctac tgcaacgtgg gcatcggctt      600

ccacctccag gcgctccccg acggccgcat cggcggcgcg cacgcggaca cccgcgacag      660

cctgctggag ctctcgcccg tggagcgggg cgtggtgagc atcttcggcg tggccagccg      720

gttcttcgtg gccatgagca gcaagggcaa gctctatggc tcgcccttct tcaccgatga      780

gtgcacgttc aaggagattc tccttcccaa caactacaac gcctacgagt cctacaagta      840

ccccggcatg ttcatcgccc tgagcaagaa tgggaagacc aagaagggga accgagtgtc      900

gcccaccatg aaggtcaccc acttcctccc caggctgtga ccctccagag gacccttgcc      960

tcagcctcgg gaagcccctg ggagggcagt gccgagggtc accttggtgc actttcttcg     1020

gatgaagagt ttaatgcaag agtaggtgta agatatttaa attaattatt taaatgtgta     1080

tatattgcca ccaaattatt tatagttctg cgggtgtgtt ttttaatttt ctggggggaa     1140

aaaaagacaa aacaaaaaac caactctgac ttttctggtg caacagtgga gaatcttacc     1200

attggatttc tttaacttgt                                                 1220


<210> 18
<211> 206
<212> PRT
<213> Homo sapiens

<400> 18
Met Ser Gly Pro Gly Thr Ala Ala Val Ala Leu Leu Pro Ala Val Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Pro Trp Ala Gly Arg Gly Gly Ala Ala Ala Pro 
            20                  25                  30          


Thr Ala Pro Asn Gly Thr Leu Glu Ala Glu Leu Glu Arg Arg Trp Glu 
        35                  40                  45              


Ser Leu Val Ala Leu Ser Leu Ala Arg Leu Pro Val Ala Ala Gln Pro 
    50                  55                  60                  


Lys Glu Ala Ala Val Gln Ser Gly Ala Gly Asp Tyr Leu Leu Gly Ile 
65                  70                  75                  80  


Lys Arg Leu Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe His Leu 
                85                  90                  95      


Gln Ala Leu Pro Asp Gly Arg Ile Gly Gly Ala His Ala Asp Thr Arg 
            100                 105                 110         


Asp Ser Leu Leu Glu Leu Ser Pro Val Glu Arg Gly Val Val Ser Ile 
        115                 120                 125             


Phe Gly Val Ala Ser Arg Phe Phe Val Ala Met Ser Ser Lys Gly Lys 
    130                 135                 140                 


Leu Tyr Gly Ser Pro Phe Phe Thr Asp Glu Cys Thr Phe Lys Glu Ile 
145                 150                 155                 160 


Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Tyr Lys Tyr Pro Gly 
                165                 170                 175     


Met Phe Ile Ala Leu Ser Lys Asn Gly Lys Thr Lys Lys Gly Asn Arg 
            180                 185                 190         


Val Ser Pro Thr Met Lys Val Thr His Phe Leu Pro Arg Leu 
        195                 200                 205     


<210> 19
<211> 3030
<212> DNA
<213> Mus musculus

<400> 19
gcgcggggac tatcccgcca ccgttgcgtc cctatttgct ctcgctactt aggtctgtgc       60

gcagcactca ccgaactcac ggcccgcagc tcgaactcac gcacggcccg cgggccggga      120

tggcgaaacg cgggccgacc acagggacgc tgctgcccag ggtcctgctg gccctggtgg      180

tggccctggc ggaccgaggg accgccgcac ccaacggcac gcggcacgca gaattggggc      240

acggctggga cggcttggtg gcccgctcgc tggcacgcct gccggtggcc gcgcagcccc      300

cgcaggcggc ggtccgcagc ggcgcagggg actacctgct gggcctcaaa aggcttcggc      360

ggctctactg caacgtgggc atcggattcc acctgcaggt gctgcccgac ggccgcatcg      420

gtggtgtgca cgcagacacg agggacagtc ttctggagct ctctccggtg cagcgaggcg      480

tggtgagcat cttcggagtg gccagccggt tcttcgtggc catgagcagc aggggcaagc      540

tcttcggtgt gcctttcttt accgacgagt gtaaattcaa agaaatactt ctgcccaaca      600

actacaacgc ctacgaatcc tacgcgtacc ccggtatgtt catggccctc agtaagaacg      660

ggcggaccaa gaaggggaac cgagtgtcgc ctaccatgaa ggtaacccac ttccttccta      720

gactgtgacc ctccggagcc ctgcctcagc ctcggaagca caccctaccc ctcaggagga      780

gcactttctc tcgatggaga attgtttgca aaaaaactgg tctaagatat ttaaattatt      840

taaatatgta tatatggacg cccaattatt tataatttta tgtattctca ttttcggggg      900

gggggatatg accaaaagaa caaacaaatt gcagctcaga cctctttgga atagcggaac      960

agacttcttt cttcactatc aaagatatgg gtgtgatgct gtttcatgtg tgcctctaaa     1020

acttggtgac atcagtttcc aagggtgcct ggcctgtaac tggaaaggcc tgcctgggac     1080

ctctgaggca gtgagaagga ccctgagcgt tcccgatcgg gagcattctg ccgtcgccgc     1140

tccctctgct tcctttggta tgaaccctgt cggatcggtt tactccaggg acagaagtcc     1200

tcccgcctct gtttttagat ctccaagact gatctttgaa ctctcttgca gtcaatcatc     1260

ttcttggacc taccggatag gagaccctta gacaacttta taaactcctg tttgccattt     1320

ttggactggc caacagggca cgttgcttgt agccactgga actttgcttt tctggagagg     1380

aactaggaat ggacaagagg gtgtgtgcgc tcgccacaac tcaaaactct ggggatgaaa     1440

ttctgttttg tgatagagga tgatttgttg ggatataaca atgtattttg caagaatcaa     1500

actgagaaaa acaggcttcc ctgaatatgg gaagctttgt gctggaactc cataatttaa     1560

gggtgagctg ccctttccca ccccaggcag cctttatgca ggcagactgc aggagtccga     1620

attccggtgc tgccccaagg tgaaggaatt ctatccccat ctacctcaga gttcctgaga     1680

ccctggtgac taagctggag gctctgctgg gtgcatctgc ctgcttctct tccacatgta     1740

gtatctggac ccttgtcacg ttccagctat ctttacccaa tgatttactt ttagtaaggg     1800

gtattcatgg tgaaaatatg cacgaccagc tgtcggagtg cactatatgg tcaccaagtc     1860

aagtaaccct tatatttttc tttatatatt ttacgaatgt aacccctgtc actgagacca     1920

aaatggaaga gcagggtcgg tggcatttaa aaaaaagggc tgaggtgagg gagaacaatt     1980

aattttaatg aatgactttg gagtttatac aaaatgacct tagctcgctt cagggaatgc     2040

ttctccccaa gatgttaaga ctctgctggg agacttctga gcaacctccc gaattaactt     2100

tatgggaggc tacagacagc aagactggaa aatctcattg gcattttttt tttttgtctt     2160

tcacattcct ttagaaaact ctttgtttgg atgctaatgg gatacttaaa atactattct     2220

gtaccacagc ccaagatgga agaagccaca ccccaaagct gaggtgggag ctcctcccaa     2280

acttcctttc tgtctggtgg ctcacaggac aataagattt tgtgtttttt aaatccaggc     2340

cctaggctcc aagagtgttg gggagaagac agttgaaatg tcttttcttc ttgttatttt     2400

ctaaaagacg gtctcatagc ccaggctgta cctgaacttg ctatgtcact aaagatgacc     2460

ttgaatttct gatcctcttg ccccatttcc tagtgctaag gttacaggca ttgcccacca     2520

cgcccactcc ttaggtgctg ggaattgaaa tcaagtgcct gccaggccac tccacagaga     2580

taggcctccc tcttttttgt gggggaggaa atgtggggtc ttactctgta gccaaggctg     2640

gcctactgct tgagcccaag tgttgagact acaggtagaa ggcacctgcc ctgttctgat     2700

gggattctct gcagctatgt tgcttcaggc aggctgtggt cctacctgac acctattacc     2760

tgtttcttca gccagctagc tccctttcct gcgcccaggg acaagactgt atctttggaa     2820

ttttgttacc agaatgggtt tgatgtttct gctctgtatc tgccactgtt accgagtcgg     2880

tctgtagtta ctacaggtgt cgacccagag atagtatgtg ctatgcacac tggatgctcc     2940

atccaaagag aagcattcaa tcatgtatag acagccccat ggactgatgg gaatgattgg     3000

gagagatatt aaaatgacaa acgtgtctgc                                      3030


<210> 20
<211> 202
<212> PRT
<213> Mus musculus

<400> 20
Met Ala Lys Arg Gly Pro Thr Thr Gly Thr Leu Leu Pro Arg Val Leu 
1               5                   10                  15      


Leu Ala Leu Val Val Ala Leu Ala Asp Arg Gly Thr Ala Ala Pro Asn 
            20                  25                  30          


Gly Thr Arg His Ala Glu Leu Gly His Gly Trp Asp Gly Leu Val Ala 
        35                  40                  45              


Arg Ser Leu Ala Arg Leu Pro Val Ala Ala Gln Pro Pro Gln Ala Ala 
    50                  55                  60                  


Val Arg Ser Gly Ala Gly Asp Tyr Leu Leu Gly Leu Lys Arg Leu Arg 
65                  70                  75                  80  


Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe His Leu Gln Val Leu Pro 
                85                  90                  95      


Asp Gly Arg Ile Gly Gly Val His Ala Asp Thr Arg Asp Ser Leu Leu 
            100                 105                 110         


Glu Leu Ser Pro Val Gln Arg Gly Val Val Ser Ile Phe Gly Val Ala 
        115                 120                 125             


Ser Arg Phe Phe Val Ala Met Ser Ser Arg Gly Lys Leu Phe Gly Val 
    130                 135                 140                 


Pro Phe Phe Thr Asp Glu Cys Lys Phe Lys Glu Ile Leu Leu Pro Asn 
145                 150                 155                 160 


Asn Tyr Asn Ala Tyr Glu Ser Tyr Ala Tyr Pro Gly Met Phe Met Ala 
                165                 170                 175     


Leu Ser Lys Asn Gly Arg Thr Lys Lys Gly Asn Arg Val Ser Pro Thr 
            180                 185                 190         


Met Lys Val Thr His Phe Leu Pro Arg Leu 
        195                 200         


<210> 21
<211> 5399
<212> DNA
<213> Homo sapiens

<400> 21
ggggaagctt cgcaggcgtg cacggagcag tgagatcact ggcgttataa atatcccggt       60

gccagcgcgg agatccgctc gggtggcctc tctcttcccc tctccccttc tcttccccga      120

ggctatgtcc acccggtgcg gcgaggcggg cagagccaga ggcacgcagc cgcacagggg      180

ctacagagcc cagaatcagc cctacaagat gcacttagga cccccgcggc tggaagaatg      240

agcttgtcct tcctcctcct cctcttcttc agccacctga tcctcagcgc ctgggctcac      300

ggggagaagc gtctcgcccc caaagggcaa cccggacccg ctgccactga taggaaccct      360

agaggctcca gcagcagaca gagcagcagt agcgctatgt cttcctcttc tgcctcctcc      420

tcccccgcag cttctctggg cagccaagga agtggcttgg agcagagcag tttccagtgg      480

agcccctcgg ggcgccggac cggcagcctc tactgcagag tgggcatcgg tttccatctg      540

cagatctacc cggatggcaa agtcaatgga tcccacgaag ccaatatgtt aagtgttttg      600

gaaatatttg ctgtgtctca ggggattgta ggaatacgag gagttttcag caacaaattt      660

ttagcgatgt caaaaaaagg aaaactccat gcaagtgcca agttcacaga tgactgcaag      720

ttcagggagc gttttcaaga aaatagctat aatacctatg cctcagcaat acatagaact      780

gaaaaaacag ggcgggagtg gtatgtggcc ctgaataaaa gaggaaaagc caaacgaggg      840

tgcagccccc gggttaaacc ccagcatatc tctacccatt ttctgccaag attcaagcag      900

tcggagcagc cagaactttc tttcacggtt actgttcctg aaaagaaaaa gccacctagc      960

cctatcaagc caaagattcc cctttctgca cctcggaaaa ataccaactc agtgaaatac     1020

agactcaagt ttcgctttgg ataatattcc tcttggcctt gtgagaaacc attctttccc     1080

ctcaggagtt tctataggtg tcttcagagt tctgaagaaa aattactgga cacagcttca     1140

gctatactta cactgtattg aagtcacgtc atttgtttca atgtgactga aacaaaatgt     1200

tttttgatag gaaggaaact ggaattcttt gtactaatac agggagcaca ctccttcagt     1260

tcagcaagac ataaagcctt ttgctttatg cttgagggat atttagaact ttgtattttc     1320

ggaaagttaa ataacaggga ctacgtattt ttctgacttt tacagattaa cctgaaagaa     1380

catacatgat acatttttat ttttggtttc caaagaatat tttgatgcag ataaaatatt     1440

ttgttaactt ttgttttttt ttgtttgttt tcttaaaagt acctctgcat tgagcatatt     1500

ttcttacttt tattatttta attaatatga cataagcaat cattttatgc tgtttatgaa     1560

ttataaatgt gtttatagct catttgtaat atggaaatct tttacatttt tcctattcac     1620

tgcacttttt tattgttttt atttctagcc atacctcaga taatatgttt agttttacat     1680

tttaaaatgt ttaaattctc tttcacagca ccaaaggctc agcttggatt tgtgtgtatg     1740

tgtatgtcaa ttcatgacat tatgtggaat cctaaacctt tggtggctgg gatatgatgg     1800

gttagaagca aggagaaaat ataaggactt tttgatggaa ttaaatgtgg gaggtaagga     1860

aaaggattta gaggtaaaag tacactaagt ttgcaacatt tattgagatc taagtctgtc     1920

ttgccttcat ttctcttttt atctccccct tgccctcatt cttgaacagc tggaggaata     1980

cattttattc tgtccatgaa gcatacacta tgaaattcaa gtgcttaaaa atacttctat     2040

gactctctgc tatcccactg tatagatcca cagggagcaa acacttagaa atgatagaga     2100

actgaaggag atcaatggtt taacagttat ccatgccaag tcccattgtc agaaatattc     2160

ttattactca gtcaaacact ctttgagctt cccttcctaa aggtaaccaa tccagtgaat     2220

agatgtgccc ttttataagg aaacttctga tgtttattaa aaaaactggc cttttgatag     2280

aggtaactta atttgggaat ttgttgtgtt gaaatggcat ttaatttcaa cctaaatact     2340

gactgctgga cataaatcac agaaaattta acttaagaaa atttacaaaa tttattctca     2400

ggtaatcatt ttaataaagt tctgcaaaat acacgtttat cttacattca gaaatgtggc     2460

aaaaaaggca tagctaaagg ctaaacatat ggctttagta gtaacaaaag ggttcataga     2520

aacttcatgg tttgcattta aacatgttta aagtgtactt ataaactatt tttttcttaa     2580

agcaaactat gatttatttt ggtgcacaaa tacaaagtgg aaacttacca aaattgaact     2640

agctaccata taagcagatt gctttaattt gatgggaaaa tagtacacac atatatataa     2700

caaataatat attaaaaaac ccatccatca actaaaacat tatatgtata catcagtata     2760

gtgttttatt ataaagccaa ttatctgatt aagcattctt tccactgaat gcataatgtt     2820

taaatagcat aaaatgaaat gctacaaaaa ttgaactaat ttatacttta aagtatttct     2880

gggttaaatg aaacaatgaa attttttagt atgttcaact ctcatccaaa tggcatatga     2940

ccctgtttac acagcctaaa gctaaaaata ttactctagt ttattctaat ctattgttaa     3000

gtattgtgca ctgtatacca agttcttagg gcacatgaaa aattttagct gccaaacagg     3060

aactagtaaa catatgttcc taataagtga agggaaagat aataatgatg gtcaacaata     3120

agccacgtca atgcataagt tgtataggct aaatgttgct tgtaggctac attaaactca     3180

aatgtaatag tttatcttat actcctggtt tgatttgatt agcatattaa cgtgaaagta     3240

ggatagctac taaatatata ttatgcaagt caggaatcat taatttcaaa atttaaagcc     3300

atgctaaaat taaaaagaaa atattaaatt acacaattac acttgtcttt actggccata     3360

caaaatgatt tttttttttt ttttgagaca gagtcttgct ctgtcaccag gctggagtgc     3420

agtggcatga tctcggctca ctgcaacctc caactccctg gtttaaggga ttctcctgcc     3480

tcagcctccc aagtagctgg gattacagac tcatgccacc acgccagcta atttttgtat     3540

ttttagtaga gacggggttt caccatgttg gtcaggatgg tctcaatcct ggcctcttga     3600

tagtcctgac ctcatgatct gcccacctcg gcctccccaa agtgctggga ttacaggtac     3660

aatgatgtat aattaatgct tagtgaagca taaagttacc tacatcaatt aattaaatga     3720

acttatgtac agaaaacatg tataaatata agtctatact aatgcttaca actttctaag     3780

agggttcttg cttatgtagc tttttattat tttaagtaac tagaaccacc aaatatcaaa     3840

taaaattatt tggttatggt tatgttcatc taaacacaac aataactttt atattaatat     3900

ttaggagtct attttgtcta taggtgacaa acatctccag actaacatgt cagttttatc     3960

aattatatta tgtttaatta tttaagattt ctttatgtgg aacatctata gagataaata     4020

gaaattttca ataagatgta gtaacactgt gatttatctt tcaagagtct ctcttcactt     4080

ccttctaaag agactaattt gagagtacag gtgcatatta attttcttgg ttctttcagc     4140

tgaattatat tggtccagaa gttcaaaatc atgtgacaat aataagggat actgacagaa     4200

gttatttcca agtttgtgta tatattataa aaattacata tataaaacta aggcttttat     4260

ttctgttatt tttaagcttt tatttcttgt agctaaaaat aaaacatcat aaatctggta     4320

ggtaaatttc ttattaaatc aatcttgaaa tagaaaatgt aataactttc ttaccattaa     4380

cattttttac ccttccatag aagggaggga ataaatcatg acttatccca ttttcaataa     4440

caaaacgaaa ctatggcact aaccaaaaac ttgcattctg gcataatttt tacagttgca     4500

gagaattgtt tctgggctca ttaaaaaaag tagtattgca gacattgctg caatgggaag     4560

cagacaataa cttcttaaag gaattctaca cctcctttaa gatttactta attgctacat     4620

ctaaattctg ataatttaaa atccatttta ggtgataaaa ttttttaaaa gttttgaagg     4680

aaacctctgg ataaatggac aaggcctaat ttttttttgt agtcaatcca actgtactgg     4740

ccaatttttg aaataagatt atatgattag gtattagcag agacaaagag ttacctcctc     4800

catcttactc tgccctattt gaaagtctca ggggagaaaa gggaacaaga tgctgatcca     4860

acctgagtgg agtcaggtga ggcatcttta catctaagaa ttttttttta aattttatta     4920

ttattatact tcaagttcta gggtacatgt ccacaatgca catgtctgtc acacatgcac     4980

acatgtgcca tgctggtgtg ctgcacccac caacctgtca tccagcatta ggtatatctc     5040

ctaatgctat ccctcccctc tccacccacc ccacagcagg ccccggtatg tgatgttccc     5100

cttcgtgtgt ccatgtgttc ttattgttca attcccacct atgagtgaga atatgtggtg     5160

tttggttttt ggtccttgca atagtttgct gagaatgatg gtttccagct tcatccatgt     5220

ccctacaaag aacatgaact catcattttt tatggctgca tagtattcca tggtgtatat     5280

gtgccacatt ttcttaatcc agtctatcat tgttggacat ttgggttggt tccaagtctt     5340

tgctattgtg aatagtgctg caataaacat atgtgtgcat gtgtctttaa aaaaaaaaa      5399


<210> 22
<211> 268
<212> PRT
<213> Homo sapiens

<400> 22
Met Ser Leu Ser Phe Leu Leu Leu Leu Phe Phe Ser His Leu Ile Leu 
1               5                   10                  15      


Ser Ala Trp Ala His Gly Glu Lys Arg Leu Ala Pro Lys Gly Gln Pro 
            20                  25                  30          


Gly Pro Ala Ala Thr Asp Arg Asn Pro Arg Gly Ser Ser Ser Arg Gln 
        35                  40                  45              


Ser Ser Ser Ser Ala Met Ser Ser Ser Ser Ala Ser Ser Ser Pro Ala 
    50                  55                  60                  


Ala Ser Leu Gly Ser Gln Gly Ser Gly Leu Glu Gln Ser Ser Phe Gln 
65                  70                  75                  80  


Trp Ser Pro Ser Gly Arg Arg Thr Gly Ser Leu Tyr Cys Arg Val Gly 
                85                  90                  95      


Ile Gly Phe His Leu Gln Ile Tyr Pro Asp Gly Lys Val Asn Gly Ser 
            100                 105                 110         


His Glu Ala Asn Met Leu Ser Val Leu Glu Ile Phe Ala Val Ser Gln 
        115                 120                 125             


Gly Ile Val Gly Ile Arg Gly Val Phe Ser Asn Lys Phe Leu Ala Met 
    130                 135                 140                 


Ser Lys Lys Gly Lys Leu His Ala Ser Ala Lys Phe Thr Asp Asp Cys 
145                 150                 155                 160 


Lys Phe Arg Glu Arg Phe Gln Glu Asn Ser Tyr Asn Thr Tyr Ala Ser 
                165                 170                 175     


Ala Ile His Arg Thr Glu Lys Thr Gly Arg Glu Trp Tyr Val Ala Leu 
            180                 185                 190         


Asn Lys Arg Gly Lys Ala Lys Arg Gly Cys Ser Pro Arg Val Lys Pro 
        195                 200                 205             


Gln His Ile Ser Thr His Phe Leu Pro Arg Phe Lys Gln Ser Glu Gln 
    210                 215                 220                 


Pro Glu Leu Ser Phe Thr Val Thr Val Pro Glu Lys Lys Lys Pro Pro 
225                 230                 235                 240 


Ser Pro Ile Lys Pro Lys Ile Pro Leu Ser Ala Pro Arg Lys Asn Thr 
                245                 250                 255     


Asn Ser Val Lys Tyr Arg Leu Lys Phe Arg Phe Gly 
            260                 265             


<210> 23
<211> 2501
<212> DNA
<213> Mus musculus

<400> 23
gcaggcgtgc acggagcagt gagatcactg gcgttataaa tatcccggtg ccagcgccga       60

gatccgctcg ggtggcctct ctctctcccc ctctccctct cccttccccg aggctatgtc      120

caccctgtgc ggcgagggag gcagcgccag aggcacgcag ccgcgcgggg gctacggagc      180

ccggagccag ccctgcaaga tgcacttagg acccccgcgg ccggaagaat gagcctgtcc      240

ttgctcttcc tcatcttctg cagccacctg atccacagcg cttgggctca cggggagaag      300

cgtctcactc ccgaagggca acccgcgcct cctaggaacc cgggagactc cagcggcagc      360

cggggcagaa gtagcgcgac gttttcttcg tcttctgcct cctcaccagt cgcagcttct      420

ccgggcagcc aaggaagcgg ctcggaacat agcagtttcc agtggagccc ttcggggcgc      480

cggaccggca gcctgtactg cagagtgggc atcggtttcc atctgcagat ctacccggat      540

ggcaaagtca atggctccca cgaagccagt gtgttaagta ttttggaaat atttgctgtg      600

tctcagggga ttgtaggaat acgaggagtt ttcagcaaca aatttttagc gatgtcaaaa      660

aaaggaaaac tccatgcaag tgccaaattt acggatgact gtaagttcag ggagagattc      720

caagaaaaca gctataatac ctatgcgtcc gcgatccaca gaactgaaaa gacaggccga      780

gagtggtacg tggccctgaa caagagaggg aaagccaaga gaggctgcag cccacgggtc      840

aaaccccaac acgtctccac ccacttccta cccaggttca agcagtccga gcaaccggaa      900

ctttccttca ccgtcactgt tccagaaaag aaaaagccac cggtgaaacc aaaggtgccc      960

ctgtcgcagc ctcgcagaag tcccagccca gtgaagtaca gactgaagtt tcgctttgga     1020

tgatgctcgt ccatcctggc cttgtgggaa acaactctct atacaggcgt catcggagcc     1080

ctgaaggaaa ctcggataca gcatccctct gctgtgccta cacgtgtgga agtcaggtca     1140

ttttgtttcg ctttgactgg aactaaactg ctttctaaaa tttaagtcga aacagaagtg     1200

ggattctctg tagcgatcca gggagctcat ctcttcagat caccgaggat ataaaggctt     1260

cgtgatttga ggatggttag cattctgcgt tttcagacca gtttgatagc ctggaactat     1320

gtacttttct catttttaca gatcaaccgg aaagaacata catgatacat gtttattttt     1380

gttttccaaa gaatattttg atgcagataa aatattttat aaacttttgt ttttttaagg     1440

tacctcagca ttgagcatat tttcttactt ttattatttt aattaacgtg acacaagcag     1500

ttggtttatt gctgttcatg gattataaac attttaatag tttgtgtggt aggatctgga     1560

tctcctttgc gtttttctct ctactacagc atcgtttact ttattttagc tatacctcaa     1620

gtcgtataaa tttagttcta cattttaaaa aaaattttta aatgtgcttt cgaagcccca     1680

aaaggctcag cttggaggtg tgcattgtgt atgaagttat ggcattatgt ggaatctggc     1740

catattagtg gctgggctca atgatcagaa ggaggaaaat atgaggacgt tttgatggat     1800

ttaaaggctt tatgtaaaga aaaggacaga ggccaccgca cactaagtgt gcagcgtcca     1860

cagagattta actctgtctt ttgcttcttc tccttttatc tgccccctgc cctcattcaa     1920

gaccagctga aggaataagt tttattctgt ccaccaagca tacactagga aactggagtg     1980

cttaaaaata cttctataac tccctgttat ccttactgta tggacccaca gggagtaact     2040

aatcagggtg tgtgtgtgtg tgtgtgtgtg tgtgtttgtg tgtgtgtgtg tgtgtgtgtg     2100

tgtgtgtgtg tgtgtagctg aaggagatga atcactaacc aagttttcat gtcaagtctc     2160

atggtcaaaa atacttctac tattcagtca aatacccttt gagctttcta ccctaaaggt     2220

aatgactgga atgagtgcat ctgctctgct ctaagaaaac ctggtgcacc ctagaagctt     2280

ctgcccttgc gacccaggag cttaattcgg gaatgtgatg agctgaaaat gacacttcat     2340

tctcaaccca aattccaaac cctcaacaga aaccacagac ggtttagctt acaaagagtt     2400

acaaaatgta ttttcttgga taatcctttt tatggagatc tatgaagtat aagtgttcac     2460

cttatattcc taaatgctgc aataaagagg cgtagatgac c                         2501


<210> 24
<211> 264
<212> PRT
<213> Mus musculus

<400> 24
Met Ser Leu Ser Leu Leu Phe Leu Ile Phe Cys Ser His Leu Ile His 
1               5                   10                  15      


Ser Ala Trp Ala His Gly Glu Lys Arg Leu Thr Pro Glu Gly Gln Pro 
            20                  25                  30          


Ala Pro Pro Arg Asn Pro Gly Asp Ser Ser Gly Ser Arg Gly Arg Ser 
        35                  40                  45              


Ser Ala Thr Phe Ser Ser Ser Ser Ala Ser Ser Pro Val Ala Ala Ser 
    50                  55                  60                  


Pro Gly Ser Gln Gly Ser Gly Ser Glu His Ser Ser Phe Gln Trp Ser 
65                  70                  75                  80  


Pro Ser Gly Arg Arg Thr Gly Ser Leu Tyr Cys Arg Val Gly Ile Gly 
                85                  90                  95      


Phe His Leu Gln Ile Tyr Pro Asp Gly Lys Val Asn Gly Ser His Glu 
            100                 105                 110         


Ala Ser Val Leu Ser Ile Leu Glu Ile Phe Ala Val Ser Gln Gly Ile 
        115                 120                 125             


Val Gly Ile Arg Gly Val Phe Ser Asn Lys Phe Leu Ala Met Ser Lys 
    130                 135                 140                 


Lys Gly Lys Leu His Ala Ser Ala Lys Phe Thr Asp Asp Cys Lys Phe 
145                 150                 155                 160 


Arg Glu Arg Phe Gln Glu Asn Ser Tyr Asn Thr Tyr Ala Ser Ala Ile 
                165                 170                 175     


His Arg Thr Glu Lys Thr Gly Arg Glu Trp Tyr Val Ala Leu Asn Lys 
            180                 185                 190         


Arg Gly Lys Ala Lys Arg Gly Cys Ser Pro Arg Val Lys Pro Gln His 
        195                 200                 205             


Val Ser Thr His Phe Leu Pro Arg Phe Lys Gln Ser Glu Gln Pro Glu 
    210                 215                 220                 


Leu Ser Phe Thr Val Thr Val Pro Glu Lys Lys Lys Pro Pro Val Lys 
225                 230                 235                 240 


Pro Lys Val Pro Leu Ser Gln Pro Arg Arg Ser Pro Ser Pro Val Lys 
                245                 250                 255     


Tyr Arg Leu Lys Phe Arg Phe Gly 
            260                 


<210> 25
<211> 856
<212> DNA
<213> Homo sapiens

<400> 25
accttgcgtc cgcagtaccg acccgcacgc tcttcagcgc atccctagtg aaggaggttc       60

tcccccagcc cgtggctgtt gcacttgctg gtcctctgcc tccaagccca gcatgtgagg      120

gagcagagcc tggtgacgga tcagctcagc cgccgcctca tccggaccta ccaactctac      180

agccgcacca gcgggaagca cgtgcaggtc ctggccaaca agcgcatcaa cgccatggca      240

gaggacggcg accccttcgc aaagctcatc gtggagacgg acacctttgg aagcagagtt      300

cgagtccgag gagccgagac gggcctctac atctgcatga acaagaaggg gaagctgatc      360

gccaagagca acggcaaagg caaggactgc gtcttcacgg agattgtgct ggagaacaac      420

tacacagcgc tgcagaatgc caagtacgag ggctggtaca tggccttcac ccgcaagggc      480

cggccccgca agggctccaa gacgcggcag caccagcgtg aggtccactt catgaagcgg      540

ctgccccggg gccaccacac caccgagcag agcctgcgct tcgagttcct caactacccg      600

cccttcacgc gcagcctgcg cggcagccag aggacttggg cccccgagcc ccgataggtg      660

ctgcctggcc ctccccacaa tgccagaccg cagagaggct catcctgtag ggcacccaaa      720

actcaagcaa gatgagctgt gcgctgctct gcaggctggg gaggtgctgg gggagccctg      780

ggttccggtt gttgatattg tttgctgttg ggtttttgct gttttttttt tttttttttt      840

ttttaaaaca aaagag                                                      856


<210> 26
<211> 140
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Glu Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp 
1               5                   10                  15      


Thr Phe Gly Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr 
            20                  25                  30          


Ile Cys Met Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys 
        35                  40                  45              


Gly Lys Asp Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr 
    50                  55                  60                  


Ala Leu Gln Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg 
65                  70                  75                  80  


Lys Gly Arg Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu 
                85                  90                  95      


Val His Phe Met Lys Arg Leu Pro Arg Gly His His Thr Thr Glu Gln 
            100                 105                 110         


Ser Leu Arg Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu 
        115                 120                 125             


Arg Gly Ser Gln Arg Thr Trp Ala Pro Glu Pro Arg 
    130                 135                 140 


<210> 27
<211> 1188
<212> DNA
<213> Mus musculus

<400> 27
cggccaccgg ctccagcagc ggctcagagg ggttcggcgc gcgcggcgag cacgacattc       60

cacgagccgc gtcgggatag ccgctggcct cccgcacccc gacctccctc agcctccgca      120

ccttcggctt gtccccccgc ggcctccagt gggacggcgt gaccccgctc gggctctcag      180

tgctcccggg gccgcgcgcc atgggcagcc cccgctccgc gctgagctgc ctgctgttgc      240

acttgctggt tctctgcctc caagcccagg aaggcccggg cggggggcct gcgctgggca      300

gggagcccac ttccctgctc cgagctggcc gggagcccca gggtgtttcc caacaggtaa      360

ctgttcagtc ctcacctaat tttacacagc atgtgaggga gcagagcctg gtgacggatc      420

agctcagccg ccgcctcatc cggacctacc agctctacag ccgcaccagc gggaagcacg      480

tgcaggtcct ggccaacaag cgcatcaacg ccatggcaga agacggagac cccttcgcga      540

agctcattgt ggagaccgat acttttggaa gcagagtccg agttcgcggc gcagagacag      600

gtctctacat ctgcatgaac aagaagggga agctaattgc caagagcaac ggcaaaggca      660

aggactgcgt attcacagag atcgtgctgg agaacaacta cacggcgctg cagaacgcca      720

agtacgaggg ctggtacatg gcctttaccc gcaagggccg gccccgcaag ggctccaaga      780

cgcgccagca tcagcgcgag gtgcacttca tgaagcgcct gccgcggggc caccacacca      840

ccgagcagag cctgcgcttc gagttcctca actacccgcc cttcacgcgc agcctgcgcg      900

gcagccagag gacttgggcc ccggagcccc gataggcgct cgcccagctc ctccccaccc      960

agccggccga ggaatccagc gggagctcgg cggcacagca aaggggaggg gctggggagc     1020

tgccttctag ttgtgcatat tgtttgctgt tgggtttttt tgttttttgt tttttgtttt     1080

tgttttttgt tttttaaaca aaagagaggc tctatttttg tattccaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                  1188


<210> 28
<211> 244
<212> PRT
<213> Mus musculus

<400> 28
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Glu Gly Pro Gly Gly Gly Pro Ala Leu 
            20                  25                  30          


Gly Arg Glu Pro Thr Ser Leu Leu Arg Ala Gly Arg Glu Pro Gln Gly 
        35                  40                  45              


Val Ser Gln Gln Val Thr Val Gln Ser Ser Pro Asn Phe Thr Gln His 
    50                  55                  60                  


Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg Arg Leu Ile 
65                  70                  75                  80  


Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His Val Gln Val 
                85                  90                  95      


Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly Asp Pro Phe 
            100                 105                 110         


Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg Val Arg Val 
        115                 120                 125             


Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys Lys Gly Lys 
    130                 135                 140                 


Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val Phe Thr Glu 
145                 150                 155                 160 


Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala Lys Tyr Glu 
                165                 170                 175     


Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg Lys Gly Ser 
            180                 185                 190         


Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys Arg Leu Pro 
        195                 200                 205             


Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu Phe Leu Asn 
    210                 215                 220                 


Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg Thr Trp Ala 
225                 230                 235                 240 


Pro Glu Pro Arg 
                


<210> 29
<211> 627
<212> DNA
<213> Homo sapiens

<400> 29
atgtggaaat ggatactgac acattgtgcc tcagcctttc cccacctgcc cggctgctgc       60

tgctgctgct ttttgttgct gttcttggtg tcttccgtcc ctgtcacctg ccaagccctt      120

ggtcaggaca tggtgtcacc agaggccacc aactcttctt cctcctcctt ctcctctcct      180

tccagcgcgg gaaggcatgt gcggagctac aatcaccttc aaggagatgt ccgctggaga      240

aagctattct ctttcaccaa gtactttctc aagattgaga agaacgggaa ggtcagcggg      300

accaagaagg agaactgccc gtacagcatc ctggagataa catcagtaga aatcggagtt      360

gttgccgtca aagccattaa cagcaactat tacttagcca tgaacaagaa ggggaaactc      420

tatggctcaa aagaatttaa caatgactgt aagctgaagg agaggataga ggaaaatgga      480

tacaatacct atgcatcatt taactggcag cataatggga ggcaaatgta tgtggcattg      540

aatggaaaag gagctccaag gagaggacag aaaacacgaa ggaaaaacac ctctgctcac      600

tttcttccaa tggtggtaca ctcatag                                          627


<210> 30
<211> 208
<212> PRT
<213> Homo sapiens

<400> 30
Met Trp Lys Trp Ile Leu Thr His Cys Ala Ser Ala Phe Pro His Leu 
1               5                   10                  15      


Pro Gly Cys Cys Cys Cys Cys Phe Leu Leu Leu Phe Leu Val Ser Ser 
            20                  25                  30          


Val Pro Val Thr Cys Gln Ala Leu Gly Gln Asp Met Val Ser Pro Glu 
        35                  40                  45              


Ala Thr Asn Ser Ser Ser Ser Ser Phe Ser Ser Pro Ser Ser Ala Gly 
    50                  55                  60                  


Arg His Val Arg Ser Tyr Asn His Leu Gln Gly Asp Val Arg Trp Arg 
65                  70                  75                  80  


Lys Leu Phe Ser Phe Thr Lys Tyr Phe Leu Lys Ile Glu Lys Asn Gly 
                85                  90                  95      


Lys Val Ser Gly Thr Lys Lys Glu Asn Cys Pro Tyr Ser Ile Leu Glu 
            100                 105                 110         


Ile Thr Ser Val Glu Ile Gly Val Val Ala Val Lys Ala Ile Asn Ser 
        115                 120                 125             


Asn Tyr Tyr Leu Ala Met Asn Lys Lys Gly Lys Leu Tyr Gly Ser Lys 
    130                 135                 140                 


Glu Phe Asn Asn Asp Cys Lys Leu Lys Glu Arg Ile Glu Glu Asn Gly 
145                 150                 155                 160 


Tyr Asn Thr Tyr Ala Ser Phe Asn Trp Gln His Asn Gly Arg Gln Met 
                165                 170                 175     


Tyr Val Ala Leu Asn Gly Lys Gly Ala Pro Arg Arg Gly Gln Lys Thr 
            180                 185                 190         


Arg Arg Lys Asn Thr Ser Ala His Phe Leu Pro Met Val Val His Ser 
        195                 200                 205             


<210> 31
<211> 4572
<212> DNA
<213> Mus musculus

<400> 31
ggctttccaa gggacttgga ggtggagaga agggcccaac aaaacgccag ccgccagccg       60

ccccccaaac aagaagtggc tttcggaaga cttcacatca acaggcacca ccaaaaagag      120

aaaggaagga gaagacaaca gcgcctgggc agctgcctcc agttctgaca actccaaaga      180

gacacttttt aagtggccag caggctggga ctctgcagag aaggaccaga aggtgccaac      240

cgcagagggg cgcagatgtc ttcctgcacc cccaccccac ccactttggg ttttgttcac      300

cgtcctgtca tctgtttttc agacctcttt tgcatctaac atggtgaaga aaggagtgaa      360

gaagagaaca aagtaacccc cggggggagc gaagagctct ggtgaccgac accaccagtt      420

cctactgccg cggccaccca cgtccactgt tcaccctgag actggagaga cgcaggcagc      480

ggatccgagg acggagcgag gacaggcagc cggtccttcc tagaagttat ggatgttggt      540

gcactcgctt ctggccagat ccgtacccag agggagctat ccagaagcca ccacctccag      600

ctgtctctct gcctcgcagc aggtcttacc cttccagtat gttccttctg atgagacaat      660

ttccagtgcc gagagtttca gtacaatgtg gaaatggata ctgacacatt gtgcctcagc      720

ctttccccac ctgccgggct gctgttgctg cttcttgttg ctctttttgg tgtcttcgtt      780

ccctgtcacc tgccaagctc ttggtcagga catggtgtca caggaggcca ccaactgctc      840

ttcttcctcc tcgtccttct cctctccttc cagtgcggga aggcatgtgc ggagctacaa      900

tcacctccaa ggagatgtcc gctggagaag gctgttctcc ttcaccaagt actttctcac      960

gattgagaag aacggcaagg tcagcgggac caagaatgaa gactgtccgt acagtgtcct     1020

ggagataaca tcagtggaaa tcggagttgt tgccgtcaaa gccatcaaca gcaactatta     1080

cttagccatg aacaagaagg ggaaactcta tggctcaaaa gagtttaaca acgactgtaa     1140

gctgaaagag agaatagagg aaaatggata caacacctat gcatctttta actggcagca     1200

caatggcagg caaatgtatg tggcattgaa tggaaaagga gctcccagga gaggacaaaa     1260

aacaagaagg aaaaacacct ctgctcactt cctccccatg acgatccaaa catagaagaa     1320

aacactgttg gtggatgcag tacaaccaat gactctttgg acagaaagag atggtatcct     1380

cactgaagac tgtagctcaa aaggcaaaga catagccctg aattcagctt gtttaaagga     1440

aggaaggctt tggatgtttt tgtactcact gctgacatac aaagttcttt tcactagctc     1500

tgtgtcattg tgtcatgcct tataatcaag atagaggcaa gtcaagtttg gatggaagtt     1560

atcctcaagt gaacaatgtt gtggtggggg ctgggctttt tttgtttgtt tgtttgtttc     1620

atttttaagt ttttgttttt gaacttctga gatagaactt aaagaacatg gaacactctg     1680

ttgaatgatc tttgggaaag ttatttatgg aatatgaaca catatcaaag actttcattg     1740

ctcattcaag cctgatgatt caatgagcag taagacacgc aagcatttac tggaaagcac     1800

ttgggtcata tcatatgcac aaccaaagga gctttgggtg tggcaccatg gaagaattgg     1860

atcagattta caaatataaa catagtagta tgaaactgtc ctaatacaaa tagtatggta     1920

tgcttgtgca ttctgtctcc atccttttct atttccttct aagttattta tttaatagga     1980

tgttaaatat cttttggggt ttaaagagta tcttcaatgc tgccctctgg tttacctttt     2040

ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct     2100

ctctctctct ctccctctct ctccctccct cccccctctg gcaccatacg cacattcatg     2160

acaaagtgtt ttaaaacctt ggcaaacact tcagaaatag gagatgagat caaggaagca     2220

gtatgaatgc cccatgcgct ctcagttgac ttaatttgca cttctgcaat aaaaaacacc     2280

agcaatgact atggcagaat tctgctatag attatgtaac agatatctgt catcatttgt     2340

caacatatat cagtccagag ggacccttac cttaaaatgt agaaggccaa attctctttc     2400

attgtcttat ttcatcttca agaatatact aaaagaagaa aaaatgaatt gttagactaa     2460

cattgttggg tttttttttt cctactgatg atggcttgcc acaggtcaca atggcaaatg     2520

atgcaaaggt tatctgcaca tacatgagcc ctttgtaagg cccacagaat ccttctccct     2580

caaaagaacc aaaaaaggaa atttggtatg aagtgcaact ctccctgggg cttaacctga     2640

gcaaatatat cctagtatat gagtaaccat atactgacac ctgttcaagc tgaatggtct     2700

agtctttaca gaaccacata aaccttgttt tctgtaaatt taaaatgttc tagaaggttc     2760

cataatataa ccacattgaa attcattttc ttagaaaagg tatagaaagc agtatgtaag     2820

tgtgccatgc accctcgctc tgtagatcac taaataaaca cgtaagcctt atttgcagtg     2880

tctgtagtga ttttaagaat gtaggaaaca cttctaaaaa aattttaaag gataactctg     2940

agatgatatt gatgctgcag tcttctttct tgtttggaaa tgtctgttta ttttcattgt     3000

ttggattcag tattttgata ggaacaaaaa gactcaccaa atgtgtctgt ttactaaaat     3060

ttaacctcta gagaggctag tgatttgtga tcctcttcta acttatttgt gctgatgctt     3120

gaccagtaca aatcagcttt ttaaaatatt attattaaag gttgatcagt cattttaaaa     3180

ttggcctttt ttttcagaat gttcctacag gtcataattt atgatttctt tgaaaagctt     3240

gcatttcaag agaaaagcac agaggcacaa tgctttggtt tatgggtata ggttgcattt     3300

tgtggtgttc tttcaacttg ttttctgaca aatgggattt ttaaaatgta tacttcttgt     3360

ggttggattc tgtatgttag agtttaattg gtaactgagt ctaaaggctc taatgtaatg     3420

aatctctaga agaactaggt atcttttttt acttttattt taaaataata attatacctg     3480

acacatgacc atggaccacc cacaaccaaa attaaatgtt tggggagaca aactatagta     3540

ttcagtgaca agggtaacag caaatagtgc agacgttgga ttcttatttc actttgccat     3600

ttagattact aaagagacta tgtgtaaaca gtcatcatta tagtactcaa gacattaaac     3660

agcttctagc aaaatgtatc aaagcttgca gagtccaaaa atagaaaaca tctttccccc     3720

tctcccaccc tacatttccc cctgtatgca tcctaacaga gataaataca aaatgaattc     3780

ggtaaggaga gaggagattc ttcttcactt catatttgtt tgatattaat agagaattct     3840

ggtccttttt acaactactg aaagaaaaga agttcagtcc taaattttgt gtgttaaaaa     3900

aagaaaagat tttgtgagtt ctgcctccgt gggaagtgtg ggcactgctc caccatgctg     3960

aagtgtgtta gccacgggta cagagcatat gactgttgac atcagactcc ttaaagatac     4020

agaatcgctt ccctcctcct aatcctcaaa aggctgaaca gtgtatatta tgttacattt     4080

aaataaaggc aataaaaatg ctgggaaaag agaataaaag tactgttctt attttatttc     4140

ctttctttct tctcttctct tttcttttct ttccttttct tttttttttc cttttttttt     4200

cttttttttt tttattagcc taaaactata cctggtaatg agatcagctc cagggctgtg     4260

tgcatggcag gatgtggtta aatgccccac agccccaaac aacaacaaca gaaaaaaaaa     4320

ttactcaaac atttgtaagg tttctttaat gttttacatg tgtgagccgg ctatccttac     4380

cctaataaca accaaatgct ttcgggttct cctaactact caggtccacc tagtttacac     4440

agtggataaa gaagaatgaa ttgaaaacaa ggatggcttg tgcaacaatg agaggctctt     4500

ggaggaaagc caggagctgc aaacgttgac ttccagggca tggaaaagac caacgaattt     4560

gatttgaaaa gt                                                         4572


<210> 32
<211> 209
<212> PRT
<213> Mus musculus

<400> 32
Met Trp Lys Trp Ile Leu Thr His Cys Ala Ser Ala Phe Pro His Leu 
1               5                   10                  15      


Pro Gly Cys Cys Cys Cys Phe Leu Leu Leu Phe Leu Val Ser Ser Phe 
            20                  25                  30          


Pro Val Thr Cys Gln Ala Leu Gly Gln Asp Met Val Ser Gln Glu Ala 
        35                  40                  45              


Thr Asn Cys Ser Ser Ser Ser Ser Ser Phe Ser Ser Pro Ser Ser Ala 
    50                  55                  60                  


Gly Arg His Val Arg Ser Tyr Asn His Leu Gln Gly Asp Val Arg Trp 
65                  70                  75                  80  


Arg Arg Leu Phe Ser Phe Thr Lys Tyr Phe Leu Thr Ile Glu Lys Asn 
                85                  90                  95      


Gly Lys Val Ser Gly Thr Lys Asn Glu Asp Cys Pro Tyr Ser Val Leu 
            100                 105                 110         


Glu Ile Thr Ser Val Glu Ile Gly Val Val Ala Val Lys Ala Ile Asn 
        115                 120                 125             


Ser Asn Tyr Tyr Leu Ala Met Asn Lys Lys Gly Lys Leu Tyr Gly Ser 
    130                 135                 140                 


Lys Glu Phe Asn Asn Asp Cys Lys Leu Lys Glu Arg Ile Glu Glu Asn 
145                 150                 155                 160 


Gly Tyr Asn Thr Tyr Ala Ser Phe Asn Trp Gln His Asn Gly Arg Gln 
                165                 170                 175     


Met Tyr Val Ala Leu Asn Gly Lys Gly Ala Pro Arg Arg Gly Gln Lys 
            180                 185                 190         


Thr Arg Arg Lys Asn Thr Ser Ala His Phe Leu Pro Met Thr Ile Gln 
        195                 200                 205             


Thr 
    


<210> 33
<211> 624
<212> DNA
<213> Homo sapiens

<400> 33
atggcagagg tggggggcgt cttcgcctcc ttggactggg atctacacgg cttctcctcg       60

tctctgggga acgtgccctt agctgactcc ccaggtttcc tgaacgagcg cctgggccaa      120

atcgagggga agctgcagcg tggctcaccc acagacttcg cccacctgaa ggggatcctg      180

cggcgccgcc agctctactg ccgcaccggc ttccacctgg agatcttccc caacggcacg      240

gtgcacggga cccgccacga ccacagccgc ttcggaatcc tggagtttat cagcctggct      300

gtggggctga tcagcatccg gggagtggac tctggcctgt acctaggaat gaatgagcga      360

ggagaactct atgggtcgaa gaaactcaca cgtgaatgtg ttttccggga acagtttgaa      420

gaaaactggt acaacaccta tgcctcaacc ttgtacaaac attcggactc agagagacag      480

tattacgtgg ccctgaacaa agatggctca ccccgggagg gatacaggac taaacgacac      540

cagaaattca ctcacttttt acccaggcct gtagatcctt ctaagttgcc ctccatgtcc      600

agagacctct ttcactatag gtaa                                             624


<210> 34
<211> 207
<212> PRT
<213> Homo sapiens

<400> 34
Met Ala Glu Val Gly Gly Val Phe Ala Ser Leu Asp Trp Asp Leu His 
1               5                   10                  15      


Gly Phe Ser Ser Ser Leu Gly Asn Val Pro Leu Ala Asp Ser Pro Gly 
            20                  25                  30          


Phe Leu Asn Glu Arg Leu Gly Gln Ile Glu Gly Lys Leu Gln Arg Gly 
        35                  40                  45              


Ser Pro Thr Asp Phe Ala His Leu Lys Gly Ile Leu Arg Arg Arg Gln 
    50                  55                  60                  


Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly Thr 
65                  70                  75                  80  


Val His Gly Thr Arg His Asp His Ser Arg Phe Gly Ile Leu Glu Phe 
                85                  90                  95      


Ile Ser Leu Ala Val Gly Leu Ile Ser Ile Arg Gly Val Asp Ser Gly 
            100                 105                 110         


Leu Tyr Leu Gly Met Asn Glu Arg Gly Glu Leu Tyr Gly Ser Lys Lys 
        115                 120                 125             


Leu Thr Arg Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp Tyr 
    130                 135                 140                 


Asn Thr Tyr Ala Ser Thr Leu Tyr Lys His Ser Asp Ser Glu Arg Gln 
145                 150                 155                 160 


Tyr Tyr Val Ala Leu Asn Lys Asp Gly Ser Pro Arg Glu Gly Tyr Arg 
                165                 170                 175     


Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val Asp 
            180                 185                 190         


Pro Ser Lys Leu Pro Ser Met Ser Arg Asp Leu Phe His Tyr Arg 
        195                 200                 205         


<210> 35
<211> 3040
<212> DNA
<213> Mus musculus

<400> 35
ccgccaagac aggcagttcg cgccccgggg ccccggctcg gcccgcgccg ccgccggccc       60

cgccatggcg gaggtcgggg gcgtctttgc ctccttggac tgggacctgc acggcttctc      120

ctcctctctg gggaacgtgc ccttagctga ctccccgggt ttcctgaacg agcgcctggg      180

ccagatcgag gggaagctgc agcgcggctc gcccacagac ttcgcccacc tgaaggggat      240

cctgcggcgc cgccagctct actgccgcac cggcttccac cttgagatct tccccaacgg      300

cacggtgcac ggcacccgcc acgaccacag ccgcttcgga attctggaat ttatcagctt      360

ggctgtgggg ctgatcagca tcaggggagt ggactctggc ctgtacctag gaatgaatga      420

gcgaggagag ctctatggat cgaagaaact cacacgtgaa tgtgttttcc gggaacagtt      480

tgaagaaaac tggtacaaca cctatgcctc caccttgtac aaacactcgg actcggagag      540

acagtattat gtggccctga ataaagacgg ctcaccccgg gagggataca ggactaaacg      600

acaccagaaa ttcactcact ttttaccaag gccagtagat ccttctaagt tgccctccat      660

gtccagagat ctcttccgct ataggtaatg gacctgtggt gccacctctg tgacccatgt      720

actctgtgac catggttggc tctgcaaaca ctatactcat agcttttcaa tccttccttc      780

ctatcaatta gataacagag aagcactcac tgttcaatgt gacccagctg tccccttgtt      840

caaagtgtat atcaaggttg ggttattttg gggagggaca tgggggaggg gtggttctga      900

gggaaatgtg tatatacttt ttgttttact catgttcttt cccgagatgt ggcattacaa      960

agaacaaggg cccccattaa gggccaaggc tgtcttgcct cacaatctac ccagatacct     1020

tgaaatgggg gtacaaatga aagaccaagg aatctgccac agatgctacc taaagagctc     1080

tgggaaagtg ttatttggaa aatcctaggg gctccaaccc tgctgcaagc catccctacc     1140

ctggctctgc agatctctca ttcgtcctga catgcagttt tcctgccacc ggaagtggga     1200

gatatggggt aggttgtaag gaaatgatat taaaatgtaa gcgtggatac tgtgcataag     1260

gacaaactat ttataaaatg tatatgctat ttattttata tatttattta tttcaaaata     1320

attttatttt taatgagaga tgctatgact ggattttctt cagaaagaat aaggtcctac     1380

tgaaacagga aaaaatgagt tattaaaggc ttttatttgg caataaaatt gtctttatat     1440

tataaaacca gtgtctaatt ctattgcttt acacattcag tagaatgaag aggctggcca     1500

gcttcttttt tttttcctcc aggttaataa aatccccaat gacaggctga tgcagcttga     1560

gctgggtaac tccatcacct agtttggtag cattatccag gcaccttctt caagacctac     1620

tgctcttttt tggtcccatg actcaaggga gctttaggaa gacctcaact cacagctcct     1680

actgaagctc ccatttgtaa accttcagga ttgggcatag aggaaccttt cttggggaca     1740

tgatgagggc ccacagctct aagaacagcg acctaatcag tggatcttta tttcagatat     1800

gaaggtgaag caaattaaaa tagtagtcag caaggagagg agtttttgag ccaatcaagt     1860

tccctgctgg aagacatcat cctactggct ctgaccatcc ccagcatctt ttaccagggc     1920

ttctagagga ttctgggaaa ctgttagcac attcccttag agcagctctt gcccagcaga     1980

atcacctgga aactgttgct caaggataga aatcagcaga aacttagttc tgggccaggc     2040

actttgcatg gtaccgagct ttccagagtt tccctaagca tgccacatca tacatgtgat     2100

ccctaagcat atagtgatag atttttgtta gtggtttttt ttttgttgtt tttttttgtt     2160

tttttttttt tttgttttgt tttttgcagg caaatggctc ataagtgaat tggtgggcaa     2220

gtgttagtcc agagaatgaa gaaggattag tttcatacct cagagctctt cctctccgag     2280

atcagcccta aagtatcttg acttcaaatc catcgactct ggtatttcca gaagtagggg     2340

tgcaagaggt tggaatcaaa gcaataaaag tcttggtgag cacaccaaca gtatgaaggc     2400

ctaattggca aaggtttgga atctaggata gttcttcctc atcctgccca ttatgaaggc     2460

atctgctact tttctaacta attgtacctg tgagtcagac agacaccagc tcacatgcaa     2520

agcaaaccca gtggtatagg tgcagatcaa tggtgaagtg cttcttagca tgggacgagc     2580

cctagattcc atccctccag caccacaaaa aagcaaaacc aaaagagcta ttaaagttca     2640

cctcaattta agtacccaat aaagaagtca cacacatatg gggatactga cctgtggtga     2700

gagctaaatt gagggctggg actatagctc aatggaagaa cactagcttt ccatggtcca     2760

gtttgtagtg ctgcaagaaa taagtcagta aataaagaca aaaactaaca aacaaaatta     2820

agttattaca tggcatgtag tcattggcta gcatgctgat tgggggaatc cctaaggtgg     2880

acatttcagt gggctaggct tagtagggtg ttttccaaca gtgataatgt ctgctttgaa     2940

gaaccaatag cattaaggaa agcaaaacat tgtttatgtt gagctatgga aaagagacac     3000

tgtctataaa attctctaaa attaaaaacc tgctacatcc                           3040


<210> 36
<211> 207
<212> PRT
<213> Mus musculus

<400> 36
Met Ala Glu Val Gly Gly Val Phe Ala Ser Leu Asp Trp Asp Leu His 
1               5                   10                  15      


Gly Phe Ser Ser Ser Leu Gly Asn Val Pro Leu Ala Asp Ser Pro Gly 
            20                  25                  30          


Phe Leu Asn Glu Arg Leu Gly Gln Ile Glu Gly Lys Leu Gln Arg Gly 
        35                  40                  45              


Ser Pro Thr Asp Phe Ala His Leu Lys Gly Ile Leu Arg Arg Arg Gln 
    50                  55                  60                  


Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly Thr 
65                  70                  75                  80  


Val His Gly Thr Arg His Asp His Ser Arg Phe Gly Ile Leu Glu Phe 
                85                  90                  95      


Ile Ser Leu Ala Val Gly Leu Ile Ser Ile Arg Gly Val Asp Ser Gly 
            100                 105                 110         


Leu Tyr Leu Gly Met Asn Glu Arg Gly Glu Leu Tyr Gly Ser Lys Lys 
        115                 120                 125             


Leu Thr Arg Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp Tyr 
    130                 135                 140                 


Asn Thr Tyr Ala Ser Thr Leu Tyr Lys His Ser Asp Ser Glu Arg Gln 
145                 150                 155                 160 


Tyr Tyr Val Ala Leu Asn Lys Asp Gly Ser Pro Arg Glu Gly Tyr Arg 
                165                 170                 175     


Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val Asp 
            180                 185                 190         


Pro Ser Lys Leu Pro Ser Met Ser Arg Asp Leu Phe Arg Tyr Arg 
        195                 200                 205         


<210> 37
<211> 1238
<212> DNA
<213> Homo sapiens

<400> 37
acctctccag cgatgggagc cgcccgcctg ctgcccaacc tcactctgtg cttacagctg       60

ctgattctct gctgtcaaac tcagggggag aatcacccgt ctcctaattt taaccagtac      120

gtgagggacc agggcgccat gaccgaccag ctgagcaggc ggcagatccg cgagtaccaa      180

ctctacagca ggaccagtgg caagcacgtg caggtcaccg ggcgtcgcat ctccgccacc      240

gccgaggacg gcaacaagtt tgccaagctc atagtggaga cggacacgtt tggcagccgg      300

gttcgcatca aaggggctga gagtgagaag tacatctgta tgaacaagag gggcaagctc      360

atcgggaagc ccagcgggaa gagcaaagac tgcgtgttca cggagatcgt gctggagaac      420

aactatacgg ccttccagaa cgcccggcac gagggctggt tcatggcctt cacgcggcag      480

gggcggcccc gccaggcttc ccgcagccgc cagaaccagc gcgaggccca cttcatcaag      540

cgcctctacc aaggccagct gcccttcccc aaccacgccg agaagcagaa gcagttcgag      600

tttgtgggct ccgcccccac ccgccggacc aagcgcacac ggcggcccca gcccctcacg      660

tagtctggga ggcagggggc agcagcccct gggccgcctc cccacccctt tcccttctta      720

atccaaggac tgggctgggg tggcgggagg ggagccagat ccccgaggga ggaccctgag      780

ggccgcgaag catccgagcc cccagctggg aaggggcagg ccggtgcccc aggggcggct      840

ggcacagtgc ccccttcccg gacgggtggc aggccctgga gaggaactga gtgtcaccct      900

gatctcaggc caccagcctc tgccggcctc ccagccgggc tcctgaagcc cgctgaaagg      960

tcagcgactg aaggccttgc agacaaccgt ctggaggtgg ctgtcctcaa aatctgcttc     1020

tcggatctcc ctcagtctgc ccccagcccc caaactcctc ctggctagac tgtaggaagg     1080

gacttttgtt tgtttgtttg tttcaggaaa aaagaaaggg agagagagga aaatagaggg     1140

ttgtccactc ctcacattcc acgacccagg cctgcacccc acccccaact cccagccccg     1200

gaataaaacc attttcctgc aaaaaaaaaa aaaaaaaa                             1238


<210> 38
<211> 216
<212> PRT
<213> Homo sapiens

<400> 38
Met Gly Ala Ala Arg Leu Leu Pro Asn Leu Thr Leu Cys Leu Gln Leu 
1               5                   10                  15      


Leu Ile Leu Cys Cys Gln Thr Gln Gly Glu Asn His Pro Ser Pro Asn 
            20                  25                  30          


Phe Asn Gln Tyr Val Arg Asp Gln Gly Ala Met Thr Asp Gln Leu Ser 
        35                  40                  45              


Arg Arg Gln Ile Arg Glu Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys 
    50                  55                  60                  


His Val Gln Val Thr Gly Arg Arg Ile Ser Ala Thr Ala Glu Asp Gly 
65                  70                  75                  80  


Asn Lys Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      


Val Arg Ile Lys Gly Ala Glu Ser Glu Lys Tyr Ile Cys Met Asn Lys 
            100                 105                 110         


Arg Gly Lys Leu Ile Gly Lys Pro Ser Gly Lys Ser Lys Asp Cys Val 
        115                 120                 125             


Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Phe Gln Asn Ala 
    130                 135                 140                 


Arg His Glu Gly Trp Phe Met Ala Phe Thr Arg Gln Gly Arg Pro Arg 
145                 150                 155                 160 


Gln Ala Ser Arg Ser Arg Gln Asn Gln Arg Glu Ala His Phe Ile Lys 
                165                 170                 175     


Arg Leu Tyr Gln Gly Gln Leu Pro Phe Pro Asn His Ala Glu Lys Gln 
            180                 185                 190         


Lys Gln Phe Glu Phe Val Gly Ser Ala Pro Thr Arg Arg Thr Lys Arg 
        195                 200                 205             


Thr Arg Arg Pro Gln Pro Leu Thr 
    210                 215     


<210> 39
<211> 1687
<212> DNA
<213> Mus musculus

<400> 39
cttaaggaga tgaggttgcc gcatcaaacc tgagggcggg agctgctgac cctgaggaag       60

gggagggcaa ggcgcctccc tccctgtgct tgccgctggc cccgcacttc acggagaccg      120

gcaggttggt gcgggtcagg aataaatcaa gagagatcgt aggggccagc ctcctgatag      180

aggacgctct cgcagctcca atcctttgcg cccggggacc tctgcccgaa gccagtagcc      240

caagagagcg agtacgccaa tcggaccagc tccggcttcg cagccccact ggcccggaag      300

gtggacacct cgcacctcag tctctcaatt acgcctcccc ttcattcccc cctcggctag      360

ccttcccctt ccctccatct cctttcattc ctgaaaacct gtggctccga gaaaccttgg      420

cttctctggg actctacctc aggggcctgg ccacatccgc tcctgagttt ggggagcaga      480

ggggcaatcg ccccaagaag tctctccagc gatgggagcc gcccgcctgc tgcctaacct      540

taccctgtgc ttgcagctat tgattctctg ctgtcaaaca cagggggaga atcacccgtc      600

tcctaatttt aaccagtacg tgagggacca gggcgctatg accgaccagc tgagcaggcg      660

gcaaatccgt gaataccagc tctacagccg gaccagtggc aagcacgtgc aggtcaccgg      720

acgtcgcatc tctgccaccg cagaggatgg caacaagttc gccaagctca tcgtggagac      780

agatacattc ggcagcagag tccgcatcaa gggggcagag agcgagaagt acatctgtat      840

gaacaagagg ggcaagctga ttgggaagcc gagcgggaag agcaaagact gcgtgttcac      900

cgagatcgta ctggagaaca actacacggc cttccagaac gcccggcacg agggctggtt      960

catggctttc actcggcagg gccggccacg ccaggcctcc cggagccgcc agaaccagcg     1020

agaggcccac ttcatcaagc gcctctacca aggccagctg ccttttccca accacgctga     1080

aaggcagaag cagttcgaat ttgtgggctc cgcccccact cgcaggacca agcgcactcg     1140

gaggccccag tcccaaacgt agtcagggag gccagtagtg tgccaggctg ggtagatgcc     1200

cctcagcagc cttccctctc ttctctaact catccaaaga tgggggctgg ggaggaaggt     1260

ggggagccag tctccaaaag gaccccgagg gcatgaagtt tctgatcccc actgggaaga     1320

gacagtactt gtgtatccca gggtgggcac cattctatgg aacaggtttg aggccagagg     1380

cagaccccgg cagaagaaat agggtctcct tgacctaaaa tgcctgcttc ccagcgtcta     1440

cctgaaataa gcgggctgct cagcagattc cagagcttgc acaactgtgc tcaaatcttg     1500

ctccctgaac ctctctgaat ctgaaccaaa tagccaaact cttggccaga ccgtagggac     1560

ttacggtttt gttttcaaaa acagacagag acagaaagag aaacaaaagc cagtcagcca     1620

ctgttcttat ttctcgcccc aggcctgcgt ccccacccca agccccagaa taaaaccatt     1680

ttcctgc                                                               1687


<210> 40
<211> 216
<212> PRT
<213> Mus musculus

<400> 40
Met Gly Ala Ala Arg Leu Leu Pro Asn Leu Thr Leu Cys Leu Gln Leu 
1               5                   10                  15      


Leu Ile Leu Cys Cys Gln Thr Gln Gly Glu Asn His Pro Ser Pro Asn 
            20                  25                  30          


Phe Asn Gln Tyr Val Arg Asp Gln Gly Ala Met Thr Asp Gln Leu Ser 
        35                  40                  45              


Arg Arg Gln Ile Arg Glu Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys 
    50                  55                  60                  


His Val Gln Val Thr Gly Arg Arg Ile Ser Ala Thr Ala Glu Asp Gly 
65                  70                  75                  80  


Asn Lys Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      


Val Arg Ile Lys Gly Ala Glu Ser Glu Lys Tyr Ile Cys Met Asn Lys 
            100                 105                 110         


Arg Gly Lys Leu Ile Gly Lys Pro Ser Gly Lys Ser Lys Asp Cys Val 
        115                 120                 125             


Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Phe Gln Asn Ala 
    130                 135                 140                 


Arg His Glu Gly Trp Phe Met Ala Phe Thr Arg Gln Gly Arg Pro Arg 
145                 150                 155                 160 


Gln Ala Ser Arg Ser Arg Gln Asn Gln Arg Glu Ala His Phe Ile Lys 
                165                 170                 175     


Arg Leu Tyr Gln Gly Gln Leu Pro Phe Pro Asn His Ala Glu Arg Gln 
            180                 185                 190         


Lys Gln Phe Glu Phe Val Gly Ser Ala Pro Thr Arg Arg Thr Lys Arg 
        195                 200                 205             


Thr Arg Arg Pro Gln Ser Gln Thr 
    210                 215     


<210> 41
<211> 1999
<212> DNA
<213> Homo sapiens

<400> 41
cacggccgga gagacgcgga ggaggagaca tgagccggcg ggcgcccaga cggagcggcc       60

gtgacgcttt cgcgctgcag ccgcgcgccc cgaccccgga gcgctgaccc ctggccccac      120

gcagctccgc gcccgggccg gagagcgcaa ctcggcttcc agacccgccg cgcatgctgt      180

ccccggactg agccgggcag ccagcctccc acggacgccc ggacggccgg ccggccagca      240

gtgagcgagc ttccccgcac cggccaggcg cctcctgcac agcggctgcc gccccgcagc      300

ccctgcgcca gcccggaggg cgcagcgctc gggaggagcc gcgcggggcg ctgatgccgc      360

agggcgcgcc gcggagcgcc ccggagcagc agagtctgca gcagcagcag ccggcgagga      420

gggagcagca gcagcggcgg cggcggcggc ggcggcggcg gaggcgcccg gtcccggccg      480

cgcggagcgg acatgtgcag gctgggctag gagccgccgc ctccctcccg cccagcgatg      540

tattcagcgc cctccgcctg cacttgcctg tgtttacact tcctgctgct gtgcttccag      600

gtacaggtgc tggttgccga ggagaacgtg gacttccgca tccacgtgga gaaccagacg      660

cgggctcggg acgatgtgag ccgtaagcag ctgcggctgt accagctcta cagccggacc      720

agtgggaaac acatccaggt cctgggccgc aggatcagtg cccgcggcga ggatggggac      780

aagtatgccc agctcctagt ggagacagac accttcggta gtcaagtccg gatcaagggc      840

aaggagacgg aattctacct gtgcatgaac cgcaaaggca agctcgtggg gaagcccgat      900

ggcaccagca aggagtgtgt gttcatcgag aaggttctgg agaacaacta cacggccctg      960

atgtcggcta agtactccgg ctggtacgtg ggcttcacca agaaggggcg gccgcggaag     1020

ggccccaaga cccgggagaa ccagcaggac gtgcatttca tgaagcgcta ccccaagggg     1080

cagccggagc ttcagaagcc cttcaagtac acgacggtga ccaagaggtc ccgtcggatc     1140

cggcccacac accctgccta ggccaccccg ccgcggcccc tcaggtcgcc ctggccacac     1200

tcacactccc agaaaactgc atcagaggaa tatttttaca tgaaaaataa ggaagaagct     1260

ctatttttgt acattgtgtt taaaagaaga caaaaactga accaaaactc ttggggggag     1320

gggtgataag gattttattg ttgacttgaa acccccgatg acaaaagact cacgcaaagg     1380

gactgtagtc aacccacagg tgcttgtctc tctctaggaa cagacaactc taaactcgtc     1440

cccagaggag gacttgaatg aggaaaccaa cactttgaga aaccaaagtc ctttttccca     1500

aaggttctga aaggaaaaaa aaaaaaaaca aaaaaaaaga aaaacaaaga gaaagtagta     1560

ctccgcccac caacaaactc cccctaactt tcccaatcct ctgttcctgc cccaaactcc     1620

aacaaaaatc gctctctggt ttgcagtcat ttatttattg tccgctgcaa gctgccccga     1680

gacaccgcgc agggaaggcg tgcccctggg aattctccgc gcctcgacct cccgacgaca     1740

gacgcctcgt ccaatcatgg tgaccctgcc ttgctcgcag ttctggagga tgctgctatc     1800

gaccttccgt gactcacgtg acctagtaca ccaatgataa gggaatattt taaaaccagc     1860

tatattatat atattatata tatataagct atttatttca cctctctgta tattgcagtt     1920

tcatgaacca agtattactg cctcaacaat taaaaacaac agacaaatta tttaaaaaac     1980

caaaaaaaaa aaaaaaaaa                                                  1999


<210> 42
<211> 207
<212> PRT
<213> Homo sapiens

<400> 42
Met Tyr Ser Ala Pro Ser Ala Cys Thr Cys Leu Cys Leu His Phe Leu 
1               5                   10                  15      


Leu Leu Cys Phe Gln Val Gln Val Leu Val Ala Glu Glu Asn Val Asp 
            20                  25                  30          


Phe Arg Ile His Val Glu Asn Gln Thr Arg Ala Arg Asp Asp Val Ser 
        35                  40                  45              


Arg Lys Gln Leu Arg Leu Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys 
    50                  55                  60                  


His Ile Gln Val Leu Gly Arg Arg Ile Ser Ala Arg Gly Glu Asp Gly 
65                  70                  75                  80  


Asp Lys Tyr Ala Gln Leu Leu Val Glu Thr Asp Thr Phe Gly Ser Gln 
                85                  90                  95      


Val Arg Ile Lys Gly Lys Glu Thr Glu Phe Tyr Leu Cys Met Asn Arg 
            100                 105                 110         


Lys Gly Lys Leu Val Gly Lys Pro Asp Gly Thr Ser Lys Glu Cys Val 
        115                 120                 125             


Phe Ile Glu Lys Val Leu Glu Asn Asn Tyr Thr Ala Leu Met Ser Ala 
    130                 135                 140                 


Lys Tyr Ser Gly Trp Tyr Val Gly Phe Thr Lys Lys Gly Arg Pro Arg 
145                 150                 155                 160 


Lys Gly Pro Lys Thr Arg Glu Asn Gln Gln Asp Val His Phe Met Lys 
                165                 170                 175     


Arg Tyr Pro Lys Gly Gln Pro Glu Leu Gln Lys Pro Phe Lys Tyr Thr 
            180                 185                 190         


Thr Val Thr Lys Arg Ser Arg Arg Ile Arg Pro Thr His Pro Ala 
        195                 200                 205         


<210> 43
<211> 1094
<212> DNA
<213> Mus musculus

<400> 43
ggcacgagcg gcaaggaggg agcagcagca gcggcggcgg cggcggcggc ggcggcggag       60

gcgcccggtc ccggccgcgc ggagcggaca tgtgcaggct gggctaggag ccgccgcctc      120

cccccccgcc ccgcgatgta ttcagcgccc tccgcctgca cttgcctgtg tttacacttt      180

ctactgctgt gcttccaggt tcaggtgttg gcagccgagg agaatgtgga cttccgcatc      240

cacgtggaga accagacgcg ggctcgagat gatgtgagtc ggaagcagct gcgcttgtac      300

cagctctata gcaggaccag tgggaagcac attcaagtcc tgggccgtag gatcagtgcc      360

cgtggcgagg acggggacaa gtatgcccag ctcctagtgg agacagatac cttcgggagt      420

caagtccgga tcaagggcaa ggagacagaa ttctacctgt gtatgaaccg aaaaggcaag      480

ctcgtgggga agcctgatgg tactagcaag gagtgcgtgt tcattgagaa ggttctggaa      540

aacaactaca cggccctgat gtctgccaag tactctggtt ggtatgtggg cttcaccaag      600

aaggggcggc ctcgcaaggg tcccaagacc cgcgagaacc agcaagatgt acacttcatg      660

aagcgttacc ccaagggaca ggccgagctg cagaagccct tcaaatacac cacagtcacc      720

aagcgatccc ggcggatccg ccccactcac cccggctagg tccggccaca ctcacccccc      780

cagagaacta catcagagga atatttttac atgaaaaata aggaagaatc tctatttttg      840

tacattgtgt ttaaaagaag acaaaaactg aacctaaagt cttgggagga ggggcgatag      900

gattccactg ttgacctgaa ccccatgaca aaggactcac acaaggggac cgctgtcaac      960

ccacaggtgc ttgcctctct ctaggaggtg acaattcaaa actcatcccc agaggaggac     1020

ttgaacgagg aaactgcgag aaaccaaagt cctttccccc caaaggttct gaaagcaaac     1080

aaaacaaaaa caaa                                                       1094


<210> 44
<211> 207
<212> PRT
<213> Mus musculus

<400> 44
Met Tyr Ser Ala Pro Ser Ala Cys Thr Cys Leu Cys Leu His Phe Leu 
1               5                   10                  15      


Leu Leu Cys Phe Gln Val Gln Val Leu Ala Ala Glu Glu Asn Val Asp 
            20                  25                  30          


Phe Arg Ile His Val Glu Asn Gln Thr Arg Ala Arg Asp Asp Val Ser 
        35                  40                  45              


Arg Lys Gln Leu Arg Leu Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys 
    50                  55                  60                  


His Ile Gln Val Leu Gly Arg Arg Ile Ser Ala Arg Gly Glu Asp Gly 
65                  70                  75                  80  


Asp Lys Tyr Ala Gln Leu Leu Val Glu Thr Asp Thr Phe Gly Ser Gln 
                85                  90                  95      


Val Arg Ile Lys Gly Lys Glu Thr Glu Phe Tyr Leu Cys Met Asn Arg 
            100                 105                 110         


Lys Gly Lys Leu Val Gly Lys Pro Asp Gly Thr Ser Lys Glu Cys Val 
        115                 120                 125             


Phe Ile Glu Lys Val Leu Glu Asn Asn Tyr Thr Ala Leu Met Ser Ala 
    130                 135                 140                 


Lys Tyr Ser Gly Trp Tyr Val Gly Phe Thr Lys Lys Gly Arg Pro Arg 
145                 150                 155                 160 


Lys Gly Pro Lys Thr Arg Glu Asn Gln Gln Asp Val His Phe Met Lys 
                165                 170                 175     


Arg Tyr Pro Lys Gly Gln Ala Glu Leu Gln Lys Pro Phe Lys Tyr Thr 
            180                 185                 190         


Thr Val Thr Lys Arg Ser Arg Arg Ile Arg Pro Thr His Pro Gly 
        195                 200                 205         


<210> 45
<211> 1016
<212> DNA
<213> Homo sapiens

<400> 45
agcgacctca gaggagtaac cgggccttaa ctttttgcgc tcgttttgct ataatttttc       60

tctatccacc tccatcccac ccccacaaca ctctttactg ggggggtctt ttgtgttccg      120

gatctccccc tccatggctc ccttagccga agtcgggggc tttctgggcg gcctggaggg      180

cttgggccag caggtgggtt cgcatttcct gttgcctcct gccggggagc ggccgccgct      240

gctgggcgag cgcaggagcg cggcggagcg gagcgcgcgc ggcgggccgg gggctgcgca      300

gctggcgcac ctgcacggca tcctgcgccg ccggcagctc tattgccgca ccggcttcca      360

cctgcagatc ctgcccgacg gcagcgtgca gggcacccgg caggaccaca gcctcttcgg      420

tatcttggaa ttcatcagtg tggcagtggg actggtcagt attagaggtg tggacagtgg      480

tctctatctt ggaatgaatg acaaaggaga actctatgga tcagagaaac ttacttccga      540

atgcatcttt agggagcagt ttgaagagaa ctggtataac acctattcat ctaacatata      600

taaacatgga gacactggcc gcaggtattt tgtggcactt aacaaagacg gaactccaag      660

agatggcgcc aggtccaaga ggcatcagaa atttacacat ttcttaccta gaccagtgga      720

tccagaaaga gttccagaat tgtacaagga cctactgatg tacacttgaa gtgcgatagt      780

gacattatgg aagagtcaaa ccacaaccat tctttcttgt catagttccc atcataaaat      840

aatgacccaa ggagacgttc aaaatattaa agtctatttt ctactgagag actggatttg      900

gaaagaatat tgagaaaaaa aaccaaaaaa aattttgact agaaatagat catgatcact      960

ctttatatgt ggattaagtt cccttagata cattggatta gtccttacca gtagac         1016


<210> 46
<211> 211
<212> PRT
<213> Homo sapiens

<400> 46
Met Ala Pro Leu Ala Glu Val Gly Gly Phe Leu Gly Gly Leu Glu Gly 
1               5                   10                  15      


Leu Gly Gln Gln Val Gly Ser His Phe Leu Leu Pro Pro Ala Gly Glu 
            20                  25                  30          


Arg Pro Pro Leu Leu Gly Glu Arg Arg Ser Ala Ala Glu Arg Ser Ala 
        35                  40                  45              


Arg Gly Gly Pro Gly Ala Ala Gln Leu Ala His Leu His Gly Ile Leu 
    50                  55                  60                  


Arg Arg Arg Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Gln Ile Leu 
65                  70                  75                  80  


Pro Asp Gly Ser Val Gln Gly Thr Arg Gln Asp His Ser Leu Phe Gly 
                85                  90                  95      


Ile Leu Glu Phe Ile Ser Val Ala Val Gly Leu Val Ser Ile Arg Gly 
            100                 105                 110         


Val Asp Ser Gly Leu Tyr Leu Gly Met Asn Asp Lys Gly Glu Leu Tyr 
        115                 120                 125             


Gly Ser Glu Lys Leu Thr Ser Glu Cys Ile Phe Arg Glu Gln Phe Glu 
    130                 135                 140                 


Glu Asn Trp Tyr Asn Thr Tyr Ser Ser Asn Ile Tyr Lys His Gly Asp 
145                 150                 155                 160 


Thr Gly Arg Arg Tyr Phe Val Ala Leu Asn Lys Asp Gly Thr Pro Arg 
                165                 170                 175     


Asp Gly Ala Arg Ser Lys Arg His Gln Lys Phe Thr His Phe Leu Pro 
            180                 185                 190         


Arg Pro Val Asp Pro Glu Arg Val Pro Glu Leu Tyr Lys Asp Leu Leu 
        195                 200                 205             


Met Tyr Thr 
    210     


<210> 47
<211> 1476
<212> DNA
<213> Mus musculus

<400> 47
tctagatgtt tctgcaaggc cagcagccag catcctccta cccaaggaga gaagatcaat       60

ctaagagggt gcactgcacc gtccccacag ggacctcaca ggagtaaccc agccttaact      120

tttttggtac ctatttggct ataatttttc tgcattcgcc tcgccaccct tgctacactt      180

tttattggcg gtgcagaggg aagtctcctg ttttctggaa tttcagtcat cctgtccggc      240

ccgtccatgg ctcccttgac cgaagtcggg gctttcttgg gcggcctgga gggcttgagc      300

cagcaggtgg ggtcgcactt cttgctgcct cctgcagggg agaggccacc gctgttaggg      360

gagcggcggg gcgcgttgga gaggggcgcc cgcggcgggc ccggttccgt ggagctggcg      420

cacctgcacg gcatcctgcg ccgccggcag ctctactgcc gcaccggctt ccacctgcag      480

atcctgcccg acggcaccgt gcagggcacc cggcaggatc acagtctctt cggtatcctg      540

gaattcatca gtgtggcagt gggactggtc agtatcagag gtgtggacag tggcctgtac      600

cttgggatga atgacaaagg agaactttat ggatcagaga aattgacttc tgaatgcatc      660

ttcagggaac aatttgaaga gaactggtat aatacctatt cgtccaacat atataaacat      720

ggagacacgg gtcgcaggta ttttgtagca cttaacaagg atggaactcc aagagatggt      780

gccaggtcca aaagacatca aaagtttacc cactttttac caagaccagt agacccagaa      840

agagttccag aattatacaa agacctactg atgtacactt gatgaatcta gagccattgt      900

ttaaaaatca cagttcctgc tgttaaataa caccgaagaa gacgttcagg atattacggg      960

agtctgcttt tcactgaaag actctatttg ggaagaaaat tgagagtaag gaattaactt     1020

gaagcaaagc aagatcattc tccgtaagtg gattgtagtt ccttagacac gttgtttcag     1080

tcttaccagt agactgacga tgctgaaatc agttcatctg cggataatgt gaaccttgct     1140

gctgacgccg catgtctctg gataatgttt acttggacag ttatcttaaa aatagatact     1200

tcatgttgaa gaagtggatt gagatgacat aattactgcc tcataaattc tgaggacctt     1260

gtagaaaggt tagaacgtta tacataaaac aaaaatcaaa atactagatg actttgatct     1320

acaaaccaca ccacactgag atgggacttt tcttttagaa gaatggacct atttatactt     1380

ttttcaattt acaaatattt attatatata tttatttatt aaagagttta tttttactag     1440

tatatgaaga ctatacaaaa taaaacaaac aaaaag                               1476


<210> 48
<211> 211
<212> PRT
<213> Mus musculus

<400> 48
Met Ala Pro Leu Thr Glu Val Gly Ala Phe Leu Gly Gly Leu Glu Gly 
1               5                   10                  15      


Leu Ser Gln Gln Val Gly Ser His Phe Leu Leu Pro Pro Ala Gly Glu 
            20                  25                  30          


Arg Pro Pro Leu Leu Gly Glu Arg Arg Gly Ala Leu Glu Arg Gly Ala 
        35                  40                  45              


Arg Gly Gly Pro Gly Ser Val Glu Leu Ala His Leu His Gly Ile Leu 
    50                  55                  60                  


Arg Arg Arg Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Gln Ile Leu 
65                  70                  75                  80  


Pro Asp Gly Thr Val Gln Gly Thr Arg Gln Asp His Ser Leu Phe Gly 
                85                  90                  95      


Ile Leu Glu Phe Ile Ser Val Ala Val Gly Leu Val Ser Ile Arg Gly 
            100                 105                 110         


Val Asp Ser Gly Leu Tyr Leu Gly Met Asn Asp Lys Gly Glu Leu Tyr 
        115                 120                 125             


Gly Ser Glu Lys Leu Thr Ser Glu Cys Ile Phe Arg Glu Gln Phe Glu 
    130                 135                 140                 


Glu Asn Trp Tyr Asn Thr Tyr Ser Ser Asn Ile Tyr Lys His Gly Asp 
145                 150                 155                 160 


Thr Gly Arg Arg Tyr Phe Val Ala Leu Asn Lys Asp Gly Thr Pro Arg 
                165                 170                 175     


Asp Gly Ala Arg Ser Lys Arg His Gln Lys Phe Thr His Phe Leu Pro 
            180                 185                 190         


Arg Pro Val Asp Pro Glu Arg Val Pro Glu Leu Tyr Lys Asp Leu Leu 
        195                 200                 205             


Met Tyr Thr 
    210     


<210> 49
<211> 513
<212> DNA
<213> Homo sapiens

<400> 49
atgcgccgcc gcctgtggct gggcctggcc tggctgctgc tggcgcgggc gccggacgcc       60

gcgggaaccc cgagcgcgtc gcggggaccg cgcagctacc cgcacctgga gggcgacgtg      120

cgctggcggc gcctcttctc ctccactcac ttcttcctgc gcgtggatcc cggcggccgc      180

gtgcagggca cccgctggcg ccacggccag gacagcatcc tggagatccg ctctgtacac      240

gtgggcgtcg tggtcatcaa agcagtgtcc tcaggcttct acgtggccat gaaccgccgg      300

ggccgcctct acgggtcgcg actctacacc gtggactgca ggttccggga gcgcatcgaa      360

gagaacggcc acaacaccta cgcctcacag cgctggcgcc gccgcggcca gcccatgttc      420

ctggcgctgg acaggagggg ggggccccgg ccaggcggcc ggacgcggcg gtaccacctg      480

tccgcccact tcctgcccgt cctggtctcc tga                                   513


<210> 50
<211> 170
<212> PRT
<213> Homo sapiens

<400> 50
Met Arg Arg Arg Leu Trp Leu Gly Leu Ala Trp Leu Leu Leu Ala Arg 
1               5                   10                  15      


Ala Pro Asp Ala Ala Gly Thr Pro Ser Ala Ser Arg Gly Pro Arg Ser 
            20                  25                  30          


Tyr Pro His Leu Glu Gly Asp Val Arg Trp Arg Arg Leu Phe Ser Ser 
        35                  40                  45              


Thr His Phe Phe Leu Arg Val Asp Pro Gly Gly Arg Val Gln Gly Thr 
    50                  55                  60                  


Arg Trp Arg His Gly Gln Asp Ser Ile Leu Glu Ile Arg Ser Val His 
65                  70                  75                  80  


Val Gly Val Val Val Ile Lys Ala Val Ser Ser Gly Phe Tyr Val Ala 
                85                  90                  95      


Met Asn Arg Arg Gly Arg Leu Tyr Gly Ser Arg Leu Tyr Thr Val Asp 
            100                 105                 110         


Cys Arg Phe Arg Glu Arg Ile Glu Glu Asn Gly His Asn Thr Tyr Ala 
        115                 120                 125             


Ser Gln Arg Trp Arg Arg Arg Gly Gln Pro Met Phe Leu Ala Leu Asp 
    130                 135                 140                 


Arg Arg Gly Gly Pro Arg Pro Gly Gly Arg Thr Arg Arg Tyr His Leu 
145                 150                 155                 160 


Ser Ala His Phe Leu Pro Val Leu Val Ser 
                165                 170 


<210> 51
<211> 489
<212> DNA
<213> Mus musculus

<400> 51
atgcgcagcc gcctctggct gggcctagcc tggctgctgt tggcgcgggc accgggcgct       60

ccgggagggt acccgcatct ggagggcgac gtgcgctggc gccgcctctt ctcctccact      120

cactttttcc tgcgtgtgga ccttggtggt cgggtgcagg ggacgcgttg gcggcacggc      180

caggacagta tagtggagat ccgttctgtc cgtgtgggca ctgtggtgat caaagctgtg      240

tactcaggct tctatgtggc catgaatcgc aggggccgcc tctatgggtc gcgggtctac      300

tctgtggact gtaggttccg ggagcgcatc gaggagaacg gctacaacac atacgcctcg      360

cgacgttgga ggcaccgcgg ccgacccatg ttcctggcac ttgacagcca aggcattccc      420

aggcaaggca gacggacacg acggcaccaa ctgtccacac acttcctgcc agtcttggtc      480

tcgtcttga                                                              489


<210> 52
<211> 162
<212> PRT
<213> Mus musculus

<400> 52
Met Arg Ser Arg Leu Trp Leu Gly Leu Ala Trp Leu Leu Leu Ala Arg 
1               5                   10                  15      


Ala Pro Gly Ala Pro Gly Gly Tyr Pro His Leu Glu Gly Asp Val Arg 
            20                  25                  30          


Trp Arg Arg Leu Phe Ser Ser Thr His Phe Phe Leu Arg Val Asp Leu 
        35                  40                  45              


Gly Gly Arg Val Gln Gly Thr Arg Trp Arg His Gly Gln Asp Ser Ile 
    50                  55                  60                  


Val Glu Ile Arg Ser Val Arg Val Gly Thr Val Val Ile Lys Ala Val 
65                  70                  75                  80  


Tyr Ser Gly Phe Tyr Val Ala Met Asn Arg Arg Gly Arg Leu Tyr Gly 
                85                  90                  95      


Ser Arg Val Tyr Ser Val Asp Cys Arg Phe Arg Glu Arg Ile Glu Glu 
            100                 105                 110         


Asn Gly Tyr Asn Thr Tyr Ala Ser Arg Arg Trp Arg His Arg Gly Arg 
        115                 120                 125             


Pro Met Phe Leu Ala Leu Asp Ser Gln Gly Ile Pro Arg Gln Gly Arg 
    130                 135                 140                 


Arg Thr Arg Arg His Gln Leu Ser Thr His Phe Leu Pro Val Leu Val 
145                 150                 155                 160 


Ser Ser 
        


<210> 53
<211> 940
<212> DNA
<213> Homo sapiens

<400> 53
ctgtcagctg aggatccagc cgaaagagga gccaggcact caggccacct gagtctactc       60

acctggacaa ctggaatctg gcaccaattc taaaccactc agcttctccg agctcacacc      120

ccggagatca cctgaggacc cgagccattg atggactcgg acgagaccgg gttcgagcac      180

tcaggactgt gggtttctgt gctggctggt cttctgctgg gagcctgcca ggcacacccc      240

atccctgact ccagtcctct cctgcaattc gggggccaag tccggcagcg gtacctctac      300

acagatgatg cccagcagac agaagcccac ctggagatca gggaggatgg gacggtgggg      360

ggcgctgctg accagagccc cgaaagtctc ctgcagctga aagccttgaa gccgggagtt      420

attcaaatct tgggagtcaa gacatccagg ttcctgtgcc agcggccaga tggggccctg      480

tatggatcgc tccactttga ccctgaggcc tgcagcttcc gggagctgct tcttgaggac      540

ggatacaatg tttaccagtc cgaagcccac ggcctcccgc tgcacctgcc agggaacaag      600

tccccacacc gggaccctgc accccgagga ccagctcgct tcctgccact accaggcctg      660

ccccccgcac tcccggagcc acccggaatc ctggcccccc agccccccga tgtgggctcc      720

tcggaccctc tgagcatggt gggaccttcc cagggccgaa gccccagcta cgcttcctga      780

agccagaggc tgtttactat gacatctcct ctttatttat taggttattt atcttattta      840

tttttttatt tttcttactt gagataataa agagttccag aggagaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                            940


<210> 54
<211> 209
<212> PRT
<213> Homo sapiens

<400> 54
Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210> 55
<211> 947
<212> DNA
<213> Mus musculus

<400> 55
agacagcctt agtgtcttct cagctgggga ttcaacacag gagaaacagc cattcacttt       60

gcctgagccc cagtctgaac ctgacccatc cctgctgggc accggagtca gaacacaatt      120

ccagctgcct tggctcctca gccgctcgct tgccaggggc tctcccgaac ggagcgcagc      180

cctgatggaa tggatgagat ctagagttgg gaccctggga ctgtgggtcc gactgctgct      240

ggctgtcttc ctgctggggg tctaccaagc ataccccatc cctgactcca gccccctcct      300

ccagtttggg ggtcaagtcc ggcagaggta cctctacaca gatgacgacc aagacactga      360

agcccacctg gagatcaggg aggatggaac agtggtaggc gcagcacacc gcagtccaga      420

aagtctcctg gagctcaaag ccttgaagcc aggggtcatt caaatcctgg gtgtcaaagc      480

ctctaggttt ctttgccaac agccagatgg agctctctat ggatcgcctc actttgatcc      540

tgaggcctgc agcttcagag aactgctgct ggaggacggt tacaatgtgt accagtctga      600

agcccatggc ctgcccctgc gtctgcctca gaaggactcc ccaaaccagg atgcaacatc      660

ctggggacct gtgcgcttcc tgcccatgcc aggcctgctc cacgagcccc aagaccaagc      720

aggattcctg cccccagagc ccccagatgt gggctcctct gaccccctga gcatggtaga      780

gcctttacag ggccgaagcc ccagctatgc gtcctgactc ttcctgaatc tagggctgtt      840

tctttttggg tttccactta tttattacgg gtatttatct tatttattta ttttagtttt      900

tttttcttac ttggaataat aaagagtctg aaagaaaaat gtgtgtt                    947


<210> 56
<211> 210
<212> PRT
<213> Mus musculus

<400> 56
Met Glu Trp Met Arg Ser Arg Val Gly Thr Leu Gly Leu Trp Val Arg 
1               5                   10                  15      


Leu Leu Leu Ala Val Phe Leu Leu Gly Val Tyr Gln Ala Tyr Pro Ile 
            20                  25                  30          


Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 
        35                  40                  45              


Tyr Leu Tyr Thr Asp Asp Asp Gln Asp Thr Glu Ala His Leu Glu Ile 
    50                  55                  60                  


Arg Glu Asp Gly Thr Val Val Gly Ala Ala His Arg Ser Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 
                85                  90                  95      


Val Lys Ala Ser Arg Phe Leu Cys Gln Gln Pro Asp Gly Ala Leu Tyr 
            100                 105                 110         


Gly Ser Pro His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 
        115                 120                 125             


Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 
    130                 135                 140                 


Leu Arg Leu Pro Gln Lys Asp Ser Pro Asn Gln Asp Ala Thr Ser Trp 
145                 150                 155                 160 


Gly Pro Val Arg Phe Leu Pro Met Pro Gly Leu Leu His Glu Pro Gln 
                165                 170                 175     


Asp Gln Ala Gly Phe Leu Pro Pro Glu Pro Pro Asp Val Gly Ser Ser 
            180                 185                 190         


Asp Pro Leu Ser Met Val Glu Pro Leu Gln Gly Arg Ser Pro Ser Tyr 
        195                 200                 205             


Ala Ser 
    210 


