                         SEQUENCE LISTING

<110>  SADIQ, Saud A.
 
<120>  TRANSGLUTAMINADASE 6 AS A BIOMARKER FOR MULITPLE SCLEROSIS

<130>  31072

<150>  61/991,120
<151>  2014-05-09

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  2292
<212>  DNA
<213>  Homo sapiens

<400>  1
actgtcctga cggtgcacac actgctgtgt ggaggaacag aggagtccag ctggccttca       60

catggcaggg atcagagtca ccaaggtgga ctggcagcgg tcgaggaatg gcgctgccca      120

ccacacccag gagtacccct gccctgagct ggtggttcgc aggggccagt cgttcagcct      180

cacgctggag ctgagcagag ccctggactg tgaggagatc ctcatcttca cgatggagac      240

aggaccccgg gcttctgagg ccctccacac caaagctgtg ttccagacat cggagctgga      300

gcggggtgag ggctggacag cagcaaggga ggctcagatg gagaaaactc tgaccgtcag      360

tctcgccagc cctcccagtg ctgtcattgg ccgctacctg ctgagcatca ggctttcctc      420

tcaccgcaaa cacagcaacc ggaggctggg cgagtttgtt ctccttttca acccatggtg      480

tgcagaggac gatgtgtttc tggcctcaga ggaggagaga caggagtacg tgctcagcga      540

cagcggcatc atcttccgag gcgtggagaa gcacatacga gcccagggct ggaactacgg      600

gcagtttgag gaggacatcc tgaacatctg cctctccatc ctggatcgaa gccccggtca      660

ccaaaacaac ccagccaccg acgtgtcctg ccgccacaac cccatctacg tcaccagggt      720

catcagtgcc atggtgaaca gcaacaacga ccgaggtgtg gtgcaaggac agtggcaggg      780

caagtacggc ggcggcacca gcccgctgca ctggcgcggc agcgtggcca ttctgcagaa      840

gtggctcaag ggcaggtaca agccagtcaa gtacggccag tgctgggtct tcgccggagt      900

cctgtgcaca gtcctcaggt gcttggggat agccacacgg gtcgtgtcca acttcaactc      960

agcccacgac acagaccaga acctgagtgt ggacaaatac gtggactcct tcgggcggac     1020

cctggaggac ctgacagaag acagcatgtg gaatttccat gtctggaatg agagctggtt     1080

tgcccggcag gacctaggcc cctcttacaa tggctggcag gttctggatg ccacccccca     1140

ggaggagagt gaaggtgtgt tccggtgcgg cccagcctca gtcaccgcca tccgcgaggg     1200

tgatgtgcac ctggctcacg atggcccctt cgtgtttgcg gaggtcaacg ccgactacat     1260

cacctggctg tggcacgagg atgagagccg ggagcgtgta tactcaaaca cgaagaagat     1320

tgggagatgc atcagcacca aggcggtggg cagtgactcc cgcgtggaca tcactgacct     1380

ctacaagtat ccggaagggt cccggaaaga gaggcaggtg tacagcaagg cggtgaacag     1440

gctgttcggc gtggaagcct ctggaaggag aatctggatc cgcagggctg ggggtcgctg     1500

tctctggcgt gacgacctcc tggagcctgc caccaagccc agcatcgctg gcaagttcaa     1560

ggtgctagag cctcccatgc tgggccacga cctgagactg gccctgtgct tggccaacct     1620

cacctcccgg gcccagcggg tgagggtcaa cctgagcggt gccaccatcc tctatacccg     1680

caagccagtg gcagagatcc tgcatgaatc ccacgccgtg aggctggggc cgcaagaaga     1740

gaagagaatc ccaattacaa tatcttactc taagtataaa gaagacctga cagaggacaa     1800

gaagatcctg ttggctgcca tgtgccttgt caccaaagga gagaagcttc tggtggagaa     1860

ggacattact ctagaggact tcatcaccat caaggttctg ggcccagcca tggtgggagt     1920

ggcagttaca gtggaagtga cagtagtcaa ccccctcata gagagagtga aggactgtgc     1980

gctgatggtg gagggcagcg gccttctcca ggaacagctc agcatcgacg tgcctaccct     2040

ggagcctcag gagagggcct cagtccagtt tgacatcacc ccctccaaaa gtggcccaag     2100

gcagctgcag gtggaccttg taagccctca cttcccggac atcaagggct ttgtgatcgt     2160

ccatgtggcc actgccaagt gatggatcat gagggactga gaggggtgga tttggcccct     2220

gtcctcctcc tgcccattct ttgtctcttc cacatgggag ccaggaggcc tcagttaatc     2280

ctgcctcaac ct                                                         2292


<210>  2
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gly Ile Arg Val Thr Lys Val Asp Trp Gln Arg Ser Arg Asn 
1               5                   10                  15      


Gly Ala Ala His His Thr Gln Glu Tyr Pro Cys Pro Glu Leu Val Val 
            20                  25                  30          


Arg Arg Gly Gln Ser Phe Ser Leu Thr Leu Glu Leu Ser Arg Ala Leu 
        35                  40                  45              


Asp Cys Glu Glu Ile Leu Ile Phe Thr Met Glu Thr Gly Pro Arg Ala 
    50                  55                  60                  


Ser Glu Ala Leu His Thr Lys Ala Val Phe Gln Thr Ser Glu Leu Glu 
65                  70                  75                  80  


Arg Gly Glu Gly Trp Thr Ala Ala Arg Glu Ala Gln Met Glu Lys Thr 
                85                  90                  95      


Leu Thr Val Ser Leu Ala Ser Pro Pro Ser Ala Val Ile Gly Arg Tyr 
            100                 105                 110         


Leu Leu Ser Ile Arg Leu Ser Ser His Arg Lys His Ser Asn Arg Arg 
        115                 120                 125             


Leu Gly Glu Phe Val Leu Leu Phe Asn Pro Trp Cys Ala Glu Asp Asp 
    130                 135                 140                 


Val Phe Leu Ala Ser Glu Glu Glu Arg Gln Glu Tyr Val Leu Ser Asp 
145                 150                 155                 160 


Ser Gly Ile Ile Phe Arg Gly Val Glu Lys His Ile Arg Ala Gln Gly 
                165                 170                 175     


Trp Asn Tyr Gly Gln Phe Glu Glu Asp Ile Leu Asn Ile Cys Leu Ser 
            180                 185                 190         


Ile Leu Asp Arg Ser Pro Gly His Gln Asn Asn Pro Ala Thr Asp Val 
        195                 200                 205             


Ser Cys Arg His Asn Pro Ile Tyr Val Thr Arg Val Ile Ser Ala Met 
    210                 215                 220                 


Val Asn Ser Asn Asn Asp Arg Gly Val Val Gln Gly Gln Trp Gln Gly 
225                 230                 235                 240 


Lys Tyr Gly Gly Gly Thr Ser Pro Leu His Trp Arg Gly Ser Val Ala 
                245                 250                 255     


Ile Leu Gln Lys Trp Leu Lys Gly Arg Tyr Lys Pro Val Lys Tyr Gly 
            260                 265                 270         


Gln Cys Trp Val Phe Ala Gly Val Leu Cys Thr Val Leu Arg Cys Leu 
        275                 280                 285             


Gly Ile Ala Thr Arg Val Val Ser Asn Phe Asn Ser Ala His Asp Thr 
    290                 295                 300                 


Asp Gln Asn Leu Ser Val Asp Lys Tyr Val Asp Ser Phe Gly Arg Thr 
305                 310                 315                 320 


Leu Glu Asp Leu Thr Glu Asp Ser Met Trp Asn Phe His Val Trp Asn 
                325                 330                 335     


Glu Ser Trp Phe Ala Arg Gln Asp Leu Gly Pro Ser Tyr Asn Gly Trp 
            340                 345                 350         


Gln Val Leu Asp Ala Thr Pro Gln Glu Glu Ser Glu Gly Val Phe Arg 
        355                 360                 365             


Cys Gly Pro Ala Ser Val Thr Ala Ile Arg Glu Gly Asp Val His Leu 
    370                 375                 380                 


Ala His Asp Gly Pro Phe Val Phe Ala Glu Val Asn Ala Asp Tyr Ile 
385                 390                 395                 400 


Thr Trp Leu Trp His Glu Asp Glu Ser Arg Glu Arg Val Tyr Ser Asn 
                405                 410                 415     


Thr Lys Lys Ile Gly Arg Cys Ile Ser Thr Lys Ala Val Gly Ser Asp 
            420                 425                 430         


Ser Arg Val Asp Ile Thr Asp Leu Tyr Lys Tyr Pro Glu Gly Ser Arg 
        435                 440                 445             


Lys Glu Arg Gln Val Tyr Ser Lys Ala Val Asn Arg Leu Phe Gly Val 
    450                 455                 460                 


Glu Ala Ser Gly Arg Arg Ile Trp Ile Arg Arg Ala Gly Gly Arg Cys 
465                 470                 475                 480 


Leu Trp Arg Asp Asp Leu Leu Glu Pro Ala Thr Lys Pro Ser Ile Ala 
                485                 490                 495     


Gly Lys Phe Lys Val Leu Glu Pro Pro Met Leu Gly His Asp Leu Arg 
            500                 505                 510         


Leu Ala Leu Cys Leu Ala Asn Leu Thr Ser Arg Ala Gln Arg Val Arg 
        515                 520                 525             


Val Asn Leu Ser Gly Ala Thr Ile Leu Tyr Thr Arg Lys Pro Val Ala 
    530                 535                 540                 


Glu Ile Leu His Glu Ser His Ala Val Arg Leu Gly Pro Gln Glu Glu 
545                 550                 555                 560 


Lys Arg Ile Pro Ile Thr Ile Ser Tyr Ser Lys Tyr Lys Glu Asp Leu 
                565                 570                 575     


Thr Glu Asp Lys Lys Ile Leu Leu Ala Ala Met Cys Leu Val Thr Lys 
            580                 585                 590         


Gly Glu Lys Leu Leu Val Glu Lys Asp Ile Thr Leu Glu Asp Phe Ile 
        595                 600                 605             


Thr Ile Lys Val Leu Gly Pro Ala Met Val Gly Val Ala Val Thr Val 
    610                 615                 620                 


Glu Val Thr Val Val Asn Pro Leu Ile Glu Arg Val Lys Asp Cys Ala 
625                 630                 635                 640 


Leu Met Val Glu Gly Ser Gly Leu Leu Gln Glu Gln Leu Ser Ile Asp 
                645                 650                 655     


Val Pro Thr Leu Glu Pro Gln Glu Arg Ala Ser Val Gln Phe Asp Ile 
            660                 665                 670         


Thr Pro Ser Lys Ser Gly Pro Arg Gln Leu Gln Val Asp Leu Val Ser 
        675                 680                 685             


Pro His Phe Pro Asp Ile Lys Gly Phe Val Ile Val His Val Ala Thr 
    690                 695                 700                 


Ala Lys 
705     


<210>  3
<211>  2158
<212>  DNA
<213>  Homo sapiens

<400>  3
actgtcctga cggtgcacac actgctgtgt ggaggaacag aggagtccag ctggccttca       60

catggcaggg atcagagtca ccaaggtgga ctggcagcgg tcgaggaatg gcgctgccca      120

ccacacccag gagtacccct gccctgagct ggtggttcgc aggggccagt cgttcagcct      180

cacgctggag ctgagcagag ccctggactg tgaggagatc ctcatcttca cgatggagac      240

aggaccccgg gcttctgagg ccctccacac caaagctgtg ttccagacat cggagctgga      300

gcggggtgag ggctggacag cagcaaggga ggctcagatg gagaaaactc tgaccgtcag      360

tctcgccagc cctcccagtg ctgtcattgg ccgctacctg ctgagcatca ggctttcctc      420

tcaccgcaaa cacagcaacc ggaggctggg cgagtttgtt ctccttttca acccatggtg      480

tgcagaggac gatgtgtttc tggcctcaga ggaggagaga caggagtacg tgctcagcga      540

cagcggcatc atcttccgag gcgtggagaa gcacatacga gcccagggct ggaactacgg      600

gcagtttgag gaggacatcc tgaacatctg cctctccatc ctggatcgaa gccccggtca      660

ccaaaacaac ccagccaccg acgtgtcctg ccgccacaac cccatctacg tcaccagggt      720

catcagtgcc atggtgaaca gcaacaacga ccgaggtgtg gtgcaaggac agtggcaggg      780

caagtacggc ggcggcacca gcccgctgca ctggcgcggc agcgtggcca ttctgcagaa      840

gtggctcaag ggcaggtaca agccagtcaa gtacggccag tgctgggtct tcgccggagt      900

cctgtgcaca gtcctcaggt gcttggggat agccacacgg gtcgtgtcca acttcaactc      960

agcccacgac acagaccaga acctgagtgt ggacaaatac gtggactcct tcgggcggac     1020

cctggaggac ctgacagaag acagcatgtg gaatttccat gtctggaatg agagctggtt     1080

tgcccggcag gacctaggcc cctcttacaa tggctggcag gttctggatg ccacccccca     1140

ggaggagagt gaaggtgtgt tccggtgcgg cccagcctca gtcaccgcca tccgcgaggg     1200

tgatgtgcac ctggctcacg atggcccctt cgtgtttgcg gaggtcaacg ccgactacat     1260

cacctggctg tggcacgagg atgagagccg ggagcgtgta tactcaaaca cgaagaagat     1320

tgggagatgc atcagcacca aggcggtggg cagtgactcc cgcgtggaca tcactgacct     1380

ctacaagtat ccggaagggt cccggaaaga gaggcaggtg tacagcaagg cggtgaacag     1440

gctgttcggc gtggaagcct ctggaaggag aatctggatc cgcagggctg ggggtcgctg     1500

tctctggcgt gacgacctcc tggagcctgc caccaagccc agcatcgctg gcaagttcaa     1560

ggtgctagag cctcccatgc tgggccacga cctgagactg gccctgtgct tggccaacct     1620

cacctcccgg gcccagcggg tgagggtcaa cctgagcggt gccaccatcc tctatacccg     1680

caagccagtg gcagagatcc tgcatgaatc ccacgccgtg aggctggggc cgcaagaaga     1740

gaagagaatc ccaattacaa tatcttactc taagtataaa gaagacctga cagaggacaa     1800

gaagatcctg ttggctgcca tgtgccttgt caccaaagga gagaagcttc tggtggagaa     1860

ggacattact ctagaggact tcatcaccat caagcgtgcc taccctggag cctcaggaga     1920

gggcctcagt ccagtttgac atcaccccct ccaaaagtgg cccaaggcag ctgcaggtgg     1980

accttgtaag ccctcacttc ccggacatca agggctttgt gatcgtccat gtggccactg     2040

ccaagtgatg gatcatgagg gactgagagg ggtggatttg gcccctgtcc tcctcctgcc     2100

cattctttgt ctcttccaca tgggagccag gaggcctcag ttaatcctgc ctcaacct       2158


<210>  4
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gly Ile Arg Val Thr Lys Val Asp Trp Gln Arg Ser Arg Asn 
1               5                   10                  15      


Gly Ala Ala His His Thr Gln Glu Tyr Pro Cys Pro Glu Leu Val Val 
            20                  25                  30          


Arg Arg Gly Gln Ser Phe Ser Leu Thr Leu Glu Leu Ser Arg Ala Leu 
        35                  40                  45              


Asp Cys Glu Glu Ile Leu Ile Phe Thr Met Glu Thr Gly Pro Arg Ala 
    50                  55                  60                  


Ser Glu Ala Leu His Thr Lys Ala Val Phe Gln Thr Ser Glu Leu Glu 
65                  70                  75                  80  


Arg Gly Glu Gly Trp Thr Ala Ala Arg Glu Ala Gln Met Glu Lys Thr 
                85                  90                  95      


Leu Thr Val Ser Leu Ala Ser Pro Pro Ser Ala Val Ile Gly Arg Tyr 
            100                 105                 110         


Leu Leu Ser Ile Arg Leu Ser Ser His Arg Lys His Ser Asn Arg Arg 
        115                 120                 125             


Leu Gly Glu Phe Val Leu Leu Phe Asn Pro Trp Cys Ala Glu Asp Asp 
    130                 135                 140                 


Val Phe Leu Ala Ser Glu Glu Glu Arg Gln Glu Tyr Val Leu Ser Asp 
145                 150                 155                 160 


Ser Gly Ile Ile Phe Arg Gly Val Glu Lys His Ile Arg Ala Gln Gly 
                165                 170                 175     


Trp Asn Tyr Gly Gln Phe Glu Glu Asp Ile Leu Asn Ile Cys Leu Ser 
            180                 185                 190         


Ile Leu Asp Arg Ser Pro Gly His Gln Asn Asn Pro Ala Thr Asp Val 
        195                 200                 205             


Ser Cys Arg His Asn Pro Ile Tyr Val Thr Arg Val Ile Ser Ala Met 
    210                 215                 220                 


Val Asn Ser Asn Asn Asp Arg Gly Val Val Gln Gly Gln Trp Gln Gly 
225                 230                 235                 240 


Lys Tyr Gly Gly Gly Thr Ser Pro Leu His Trp Arg Gly Ser Val Ala 
                245                 250                 255     


Ile Leu Gln Lys Trp Leu Lys Gly Arg Tyr Lys Pro Val Lys Tyr Gly 
            260                 265                 270         


Gln Cys Trp Val Phe Ala Gly Val Leu Cys Thr Val Leu Arg Cys Leu 
        275                 280                 285             


Gly Ile Ala Thr Arg Val Val Ser Asn Phe Asn Ser Ala His Asp Thr 
    290                 295                 300                 


Asp Gln Asn Leu Ser Val Asp Lys Tyr Val Asp Ser Phe Gly Arg Thr 
305                 310                 315                 320 


Leu Glu Asp Leu Thr Glu Asp Ser Met Trp Asn Phe His Val Trp Asn 
                325                 330                 335     


Glu Ser Trp Phe Ala Arg Gln Asp Leu Gly Pro Ser Tyr Asn Gly Trp 
            340                 345                 350         


Gln Val Leu Asp Ala Thr Pro Gln Glu Glu Ser Glu Gly Val Phe Arg 
        355                 360                 365             


Cys Gly Pro Ala Ser Val Thr Ala Ile Arg Glu Gly Asp Val His Leu 
    370                 375                 380                 


Ala His Asp Gly Pro Phe Val Phe Ala Glu Val Asn Ala Asp Tyr Ile 
385                 390                 395                 400 


Thr Trp Leu Trp His Glu Asp Glu Ser Arg Glu Arg Val Tyr Ser Asn 
                405                 410                 415     


Thr Lys Lys Ile Gly Arg Cys Ile Ser Thr Lys Ala Val Gly Ser Asp 
            420                 425                 430         


Ser Arg Val Asp Ile Thr Asp Leu Tyr Lys Tyr Pro Glu Gly Ser Arg 
        435                 440                 445             


Lys Glu Arg Gln Val Tyr Ser Lys Ala Val Asn Arg Leu Phe Gly Val 
    450                 455                 460                 


Glu Ala Ser Gly Arg Arg Ile Trp Ile Arg Arg Ala Gly Gly Arg Cys 
465                 470                 475                 480 


Leu Trp Arg Asp Asp Leu Leu Glu Pro Ala Thr Lys Pro Ser Ile Ala 
                485                 490                 495     


Gly Lys Phe Lys Val Leu Glu Pro Pro Met Leu Gly His Asp Leu Arg 
            500                 505                 510         


Leu Ala Leu Cys Leu Ala Asn Leu Thr Ser Arg Ala Gln Arg Val Arg 
        515                 520                 525             


Val Asn Leu Ser Gly Ala Thr Ile Leu Tyr Thr Arg Lys Pro Val Ala 
    530                 535                 540                 


Glu Ile Leu His Glu Ser His Ala Val Arg Leu Gly Pro Gln Glu Glu 
545                 550                 555                 560 


Lys Arg Ile Pro Ile Thr Ile Ser Tyr Ser Lys Tyr Lys Glu Asp Leu 
                565                 570                 575     


Thr Glu Asp Lys Lys Ile Leu Leu Ala Ala Met Cys Leu Val Thr Lys 
            580                 585                 590         


Gly Glu Lys Leu Leu Val Glu Lys Asp Ile Thr Leu Glu Asp Phe Ile 
        595                 600                 605             


Thr Ile Lys Arg Ala Tyr Pro Gly Ala Ser Gly Glu Gly Leu Ser Pro 
    610                 615                 620                 


Val 
625 


