                               SEQUENCE LISTING

<110> BIOGEN MA INC.
 
<120> PRODRUGS AND DRUGS

<130> B2047-7114WO

<140>
<141>

<150> 62/031,530
<151> 2014-07-31

<150> 61/990,518
<151> 2014-05-08

<160> 14    

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 1
cttccctctg gcctctcaga                                                   20


<210> 2
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 2
aatgggtgtc ccgatgtca                                                    19


<210> 3
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 3
gagatcggga cacccattac c                                                 21


<210> 4
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 4
ccggccaagt tgtgcacta                                                    19


<210> 5
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"

<400> 5
cctcttggat cccc                                                         14


<210> 6
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"

<400> 6
actctgtgat ccgtgttc                                                     18


<210> 7
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 7
gctcccggac ctggaggt                                                     18


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 8
actggatgca gaagaagcga                                                   20


<210> 9
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 9
cgcttcttct gcatccagtc c                                                 21


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 10
gcatccagtc cttgacctcc a                                                 21


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 11
tgacctccag gtccgggagc                                                   20


<210> 12
<211> 560
<212> PRT
<213> Homo sapiens

<400> 12
Met Gly Lys Trp Arg Pro Arg Gly Cys Cys Arg Gly Asn Met Gln Cys 
1               5                   10                  15      


Arg Gln Glu Val Pro Ala Thr Leu Thr Ser Ser Glu Leu Phe Ser Thr 
            20                  25                  30          


Arg Asn Gln Pro Gln Pro Gln Pro Gln Pro Leu Leu Ala Asp Ala Pro 
        35                  40                  45              


Val Pro Trp Ala Val Ala Ser Arg Met Cys Leu Thr Pro Gly Gln Gly 
    50                  55                  60                  


Cys Gly His Gln Gly Gln Asp Glu Gly Pro Leu Pro Ala Pro Ser Pro 
65                  70                  75                  80  


Pro Pro Ala Met Ser Ser Ser Arg Lys Asp His Leu Gly Ala Ser Ser 
                85                  90                  95      


Ser Glu Pro Leu Pro Val Ile Ile Val Gly Asn Gly Pro Ser Gly Ile 
            100                 105                 110         


Cys Leu Ser Tyr Leu Leu Ser Gly Tyr Thr Pro Tyr Thr Lys Pro Asp 
        115                 120                 125             


Ala Ile His Pro His Pro Leu Leu Gln Arg Lys Leu Thr Glu Ala Pro 
    130                 135                 140                 


Gly Val Ser Ile Leu Asp Gln Asp Leu Asp Tyr Leu Ser Glu Gly Leu 
145                 150                 155                 160 


Glu Gly Arg Ser Gln Ser Pro Val Ala Leu Leu Phe Asp Ala Leu Leu 
                165                 170                 175     


Arg Pro Asp Thr Asp Phe Gly Gly Asn Met Lys Ser Val Leu Thr Trp 
            180                 185                 190         


Lys His Arg Lys Glu His Ala Ile Pro His Val Val Leu Gly Arg Asn 
        195                 200                 205             


Leu Pro Gly Gly Ala Trp His Ser Ile Glu Gly Ser Met Val Ile Leu 
    210                 215                 220                 


Ser Gln Gly Gln Trp Met Gly Leu Pro Asp Leu Glu Val Lys Asp Trp 
225                 230                 235                 240 


Met Gln Lys Lys Arg Arg Gly Leu Arg Asn Ser Arg Ala Thr Ala Gly 
                245                 250                 255     


Asp Ile Ala His Tyr Tyr Arg Asp Tyr Val Val Lys Lys Gly Leu Gly 
            260                 265                 270         


His Asn Phe Val Ser Gly Ala Val Val Thr Ala Val Glu Trp Gly Thr 
        275                 280                 285             


Pro Asp Pro Ser Ser Cys Gly Ala Gln Asp Ser Ser Pro Leu Phe Gln 
    290                 295                 300                 


Val Ser Gly Phe Leu Thr Arg Asn Gln Ala Gln Gln Pro Phe Ser Leu 
305                 310                 315                 320 


Trp Ala Arg Asn Val Val Leu Ala Thr Gly Thr Phe Asp Ser Pro Ala 
                325                 330                 335     


Arg Leu Gly Ile Pro Gly Glu Ala Leu Pro Phe Ile His His Glu Leu 
            340                 345                 350         


Ser Ala Leu Glu Ala Ala Thr Arg Val Gly Ala Val Thr Pro Ala Ser 
        355                 360                 365             


Asp Pro Val Leu Ile Ile Gly Ala Gly Leu Ser Ala Ala Asp Ala Val 
    370                 375                 380                 


Leu Tyr Ala Arg His Tyr Asn Ile Pro Val Ile His Ala Phe Arg Arg 
385                 390                 395                 400 


Ala Val Asp Asp Pro Gly Leu Val Phe Asn Gln Leu Pro Lys Met Leu 
                405                 410                 415     


Tyr Pro Glu Tyr His Lys Val His Gln Met Met Arg Glu Gln Ser Ile 
            420                 425                 430         


Leu Ser Pro Ser Pro Tyr Glu Gly Tyr Arg Ser Leu Pro Arg His Gln 
        435                 440                 445             


Leu Leu Cys Phe Lys Glu Asp Cys Gln Ala Val Phe Gln Asp Leu Glu 
    450                 455                 460                 


Gly Val Glu Lys Val Phe Gly Val Ser Leu Val Leu Val Leu Ile Gly 
465                 470                 475                 480 


Ser His Pro Asp Leu Ser Phe Leu Pro Gly Ala Gly Ala Asp Phe Ala 
                485                 490                 495     


Val Asp Pro Asp Gln Pro Leu Ser Ala Lys Arg Asn Pro Ile Asp Val 
            500                 505                 510         


Asp Pro Phe Thr Tyr Gln Ser Thr Arg Gln Glu Gly Leu Tyr Ala Met 
        515                 520                 525             


Gly Pro Leu Ala Gly Asp Asn Phe Val Arg Phe Val Gln Gly Gly Ala 
    530                 535                 540                 


Leu Ala Val Ala Ser Ser Leu Leu Arg Lys Glu Thr Arg Lys Pro Pro 
545                 550                 555                 560 


<210> 13
<211> 85
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 13
cacagggtaa tgggtgtccc gatgtcacgg gggactctgt gatccgtgtt cccctgaccc       60

tcctagtgca caacttggcc gggct                                             85


<210> 14
<211> 120
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 14
acttccctct ggcctctcag agcctcttgg atccccacag ggtaatgggt gtcccgatct       60

cgcgggggac tctgtgatcc gtgttcccct gaccctccta gtgcacaact tggccgggct      120


