                         SEQUENCE LISTING

<110>  The Jackson Laboratory
 
<120>  METHODS FOR IDENTIFYING COMPOUNDS THAT ALTER THE ACTIVITY OF 
       IRHOM POLYPEPTIDES AND USE THEREOF

<130>  JLA-11352/47

<150>  61/991,423
<151>  2014-05-09

<150>  61/992,152
<151>  2014-05-12

<160>  90    

<170>  PatentIn version 3.5

<210>  1
<211>  827
<212>  PRT
<213>  Mus musculus

<400>  1

Met Ala Ser Ala Asp Lys Asn Gly Ser Asn Leu Pro Ser Val Ser Gly 
1               5                   10                  15      


Ser Arg Leu Gln Ser Arg Lys Pro Pro Asn Leu Ser Ile Thr Ile Pro 
            20                  25                  30          


Pro Pro Glu Ser Gln Ala Pro Gly Glu Gln Asp Ser Met Leu Pro Glu 
        35                  40                  45              


Arg Arg Lys Asn Pro Ala Tyr Leu Lys Ser Val Ser Leu Gln Glu Pro 
    50                  55                  60                  


Arg Gly Arg Trp Gln Glu Gly Ala Glu Lys Arg Pro Gly Phe Arg Arg 
65                  70                  75                  80  


Gln Ala Ser Leu Ser Gln Ser Ile Arg Lys Ser Thr Ala Gln Trp Phe 
                85                  90                  95      


Gly Val Ser Gly Asp Trp Glu Gly Lys Arg Gln Asn Trp His Arg Arg 
            100                 105                 110         


Ser Leu His His Cys Ser Val His Tyr Gly Arg Leu Lys Ala Ser Cys 
        115                 120                 125             


Gln Arg Glu Leu Glu Leu Pro Ser Gln Glu Val Pro Ser Phe Gln Gly 
    130                 135                 140                 


Thr Glu Ser Pro Lys Pro Cys Lys Met Pro Lys Ile Val Asp Pro Leu 
145                 150                 155                 160 


Ala Arg Gly Arg Ala Phe Arg His Pro Asp Glu Val Asp Arg Pro His 
                165                 170                 175     


Ala Ala His Pro Pro Leu Thr Pro Gly Val Leu Ser Leu Thr Ser Phe 
            180                 185                 190         


Thr Ser Val Arg Ser Gly Tyr Ser His Leu Pro Arg Arg Lys Arg Ile 
        195                 200                 205             


Ser Val Ala His Met Ser Phe Gln Ala Ala Ala Ala Leu Leu Lys Gly 
    210                 215                 220                 


Arg Ser Val Leu Asp Ala Thr Gly Gln Arg Cys Arg His Val Lys Arg 
225                 230                 235                 240 


Ser Phe Ala Tyr Pro Ser Phe Leu Glu Glu Asp Ala Val Asp Gly Ala 
                245                 250                 255     


Asp Thr Phe Asp Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met 
            260                 265                 270         


Pro Asp Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg 
        275                 280                 285             


Gly Val Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val His Ile 
    290                 295                 300                 


Pro Leu Lys Glu Tyr Ser Gly Gly Arg Ala Leu Gly Pro Gly Thr Gln 
305                 310                 315                 320 


Arg Gly Lys Arg Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg 
                325                 330                 335     


Lys Lys Arg His Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg 
            340                 345                 350         


Ser Tyr Arg Arg Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser 
        355                 360                 365             


Phe Asp Ser His Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His 
    370                 375                 380                 


Ile Ile Ile Thr Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val 
385                 390                 395                 400 


Gly Phe Ala Gln His Val Thr Thr Gln Leu Val Leu Lys Asn Arg Gly 
                405                 410                 415     


Val Tyr Glu Ser Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Ile Gly 
            420                 425                 430         


Pro Ser Ser Ile Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys 
        435                 440                 445             


Ile Arg Lys Asp Gln Gln Ile Glu Gln Leu Val Arg Arg Glu Arg Asp 
    450                 455                 460                 


Ile Glu Arg Thr Ser Gly Cys Cys Val Gln Asn Asp Arg Ser Gly Cys 
465                 470                 475                 480 


Ile Gln Thr Leu Lys Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val 
                485                 490                 495     


Lys Trp Gln Asn Asp Thr Gly Pro Ser Asp Lys Ser Asp Leu Ser Gln 
            500                 505                 510         


Lys Gln Pro Ser Ala Val Val Cys His Gln Asp Pro Arg Thr Cys Glu 
        515                 520                 525             


Glu Pro Ala Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys 
    530                 535                 540                 


Trp Pro Ile Cys Thr Glu Gln Ala Gln Ser Asn His Thr Gly Leu Leu 
545                 550                 555                 560 


His Ile Asp Cys Lys Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys 
                565                 570                 575     


Gly Ser Cys Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly 
            580                 585                 590         


Tyr Phe His Glu Asp Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp 
        595                 600                 605             


Lys Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln 
    610                 615                 620                 


Phe Tyr Arg Ile Trp Leu Ser Leu Phe Leu His Ala Gly Ile Val His 
625                 630                 635                 640 


Cys Leu Val Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu 
                645                 650                 655     


Lys Leu Ala Gly Trp His Arg Ile Ser Ile Ile Phe Ile Leu Ser Gly 
            660                 665                 670         


Ile Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu 
        675                 680                 685             


Val Gly Pro Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val 
    690                 695                 700                 


Glu Leu Phe Gln Ser Trp Gln Leu Leu Glu Arg Pro Trp Lys Ala Phe 
705                 710                 715                 720 


Phe Asn Leu Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu 
                725                 730                 735     


Pro Trp Ile Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Met 
            740                 745                 750         


Leu Leu Ala Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp 
        755                 760                 765             


Lys Tyr Arg Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Val Phe Ala 
    770                 775                 780                 


Gly Leu Phe Ala Ser Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn 
785                 790                 795                 800 


Trp Pro Trp Ile Glu Tyr Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe 
                805                 810                 815     


Cys Glu Lys Tyr Glu Leu Asp Gln Val Leu His 
            820                 825         


<210>  2
<211>  559
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ser Ser Met Pro Asp Asp Val Phe Glu Ser Pro Pro Leu Ser Ala 
1               5                   10                  15      


Ser Tyr Phe Arg Gly Val Pro His Ser Ala Ser Pro Val Ser Pro Asp 
            20                  25                  30          


Gly Val His Ile Pro Leu Lys Glu Tyr Ser Gly Gly Arg Ala Leu Gly 
        35                  40                  45              


Pro Gly Thr Gln Arg Gly Lys Arg Ile Ala Ser Lys Val Lys His Phe 
    50                  55                  60                  


Ala Phe Asp Arg Lys Lys Arg His Tyr Gly Leu Gly Val Val Gly Asn 
65                  70                  75                  80  


Trp Leu Asn Arg Ser Tyr Arg Arg Ser Ile Ser Ser Thr Val Gln Arg 
                85                  90                  95      


Gln Leu Glu Ser Phe Asp Ser His Arg Pro Tyr Phe Thr Tyr Trp Leu 
            100                 105                 110         


Thr Phe Val His Ile Ile Ile Thr Leu Leu Val Ile Cys Thr Tyr Gly 
        115                 120                 125             


Ile Ala Pro Val Gly Phe Ala Gln His Val Thr Thr Gln Leu Val Leu 
    130                 135                 140                 


Lys Asn Arg Gly Val Tyr Glu Ser Val Lys Tyr Ile Gln Gln Glu Asn 
145                 150                 155                 160 


Phe Trp Ile Gly Pro Ser Ser Ile Asp Leu Ile His Leu Gly Ala Lys 
                165                 170                 175     


Phe Ser Pro Cys Ile Arg Lys Asp Gln Gln Ile Glu Gln Leu Val Arg 
            180                 185                 190         


Arg Glu Arg Asp Ile Glu Arg Thr Ser Gly Cys Cys Val Gln Asn Asp 
        195                 200                 205             


Arg Ser Gly Cys Ile Gln Thr Leu Lys Lys Asp Cys Ser Glu Thr Leu 
    210                 215                 220                 


Ala Thr Phe Val Lys Trp Gln Asn Asp Thr Gly Pro Ser Asp Lys Ser 
225                 230                 235                 240 


Asp Leu Ser Gln Lys Gln Pro Ser Ala Val Val Cys His Gln Asp Pro 
                245                 250                 255     


Arg Thr Cys Glu Glu Pro Ala Ser Ser Gly Ala His Ile Trp Pro Asp 
            260                 265                 270         


Asp Ile Thr Lys Trp Pro Ile Cys Thr Glu Gln Ala Gln Ser Asn His 
        275                 280                 285             


Thr Gly Leu Leu His Ile Asp Cys Lys Ile Lys Gly Arg Pro Cys Cys 
    290                 295                 300                 


Ile Gly Thr Lys Gly Ser Cys Glu Ile Thr Thr Arg Glu Tyr Cys Glu 
305                 310                 315                 320 


Phe Met His Gly Tyr Phe His Glu Asp Ala Thr Leu Cys Ser Gln Val 
                325                 330                 335     


His Cys Leu Asp Lys Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu 
            340                 345                 350         


Val Pro Asp Gln Phe Tyr Arg Ile Trp Leu Ser Leu Phe Leu His Ala 
        355                 360                 365             


Gly Ile Val His Cys Leu Val Ser Val Val Phe Gln Met Thr Ile Leu 
    370                 375                 380                 


Arg Asp Leu Glu Lys Leu Ala Gly Trp His Arg Ile Ser Ile Ile Phe 
385                 390                 395                 400 


Ile Leu Ser Gly Ile Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro 
                405                 410                 415     


Tyr Arg Ala Glu Val Gly Pro Ala Gly Ser Gln Phe Gly Leu Leu Ala 
            420                 425                 430         


Cys Leu Phe Val Glu Leu Phe Gln Ser Trp Gln Leu Leu Glu Arg Pro 
        435                 440                 445             


Trp Lys Ala Phe Phe Asn Leu Ser Ala Ile Val Leu Phe Leu Phe Ile 
    450                 455                 460                 


Cys Gly Leu Leu Pro Trp Ile Asp Asn Ile Ala His Ile Phe Gly Phe 
465                 470                 475                 480 


Leu Ser Gly Met Leu Leu Ala Phe Ala Phe Leu Pro Tyr Ile Thr Phe 
                485                 490                 495     


Gly Thr Ser Asp Lys Tyr Arg Lys Arg Ala Leu Ile Leu Val Ser Leu 
            500                 505                 510         


Leu Val Phe Ala Gly Leu Phe Ala Ser Leu Val Leu Trp Leu Tyr Ile 
        515                 520                 525             


Tyr Pro Ile Asn Trp Pro Trp Ile Glu Tyr Leu Thr Cys Phe Pro Phe 
    530                 535                 540                 


Thr Ser Arg Phe Cys Glu Lys Tyr Glu Leu Asp Gln Val Leu His 
545                 550                 555                 


<210>  3
<211>  856
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ser Glu Ala Arg Arg Asp Ser Thr Ser Ser Leu Gln Arg Lys Lys 
1               5                   10                  15      


Pro Pro Trp Leu Lys Leu Asp Ile Pro Ala Ala Val Pro Pro Ala Ala 
            20                  25                  30          


Glu Glu Pro Ser Phe Leu Gln Pro Leu Arg Arg Gln Ala Phe Leu Arg 
        35                  40                  45              


Ser Val Ser Met Pro Ala Glu Thr Ala Arg Val Pro Ser Pro His His 
    50                  55                  60                  


Glu Pro Arg Arg Leu Val Leu Gln Arg Gln Thr Ser Ile Thr Gln Thr 
65                  70                  75                  80  


Ile Arg Arg Gly Thr Ala Asp Trp Phe Gly Val Ser Lys Asp Ser Asp 
                85                  90                  95      


Ser Thr Gln Lys Trp Gln Arg Lys Ser Ile Arg His Cys Ser Gln Arg 
            100                 105                 110         


Tyr Gly Lys Leu Lys Pro Gln Val Ile Arg Glu Leu Asp Leu Pro Ser 
        115                 120                 125             


Gln Asp Asn Val Ser Leu Thr Ser Thr Glu Thr Pro Pro Pro Leu Tyr 
    130                 135                 140                 


Val Gly Pro Cys Gln Leu Gly Met Gln Lys Ile Ile Asp Pro Leu Ala 
145                 150                 155                 160 


Arg Gly Arg Ala Phe Arg Met Ala Asp Asp Thr Ala Asp Gly Leu Ser 
                165                 170                 175     


Ala Pro His Thr Pro Val Thr Pro Gly Ala Ala Ser Leu Cys Ser Phe 
            180                 185                 190         


Ser Ser Ser Arg Ser Gly Phe Asn Arg Leu Pro Arg Arg Arg Lys Arg 
        195                 200                 205             


Glu Ser Val Ala Lys Met Ser Phe Arg Ala Ala Ala Ala Leu Val Lys 
    210                 215                 220                 


Gly Arg Ser Ile Arg Asp Gly Thr Leu Arg Arg Gly Gln Arg Arg Ser 
225                 230                 235                 240 


Phe Thr Pro Ala Ser Phe Leu Glu Glu Asp Met Val Asp Phe Pro Asp 
                245                 250                 255     


Glu Leu Asp Thr Ser Phe Phe Ala Arg Glu Gly Val Leu His Glu Glu 
            260                 265                 270         


Met Ser Thr Tyr Pro Asp Glu Val Phe Glu Ser Pro Ser Glu Ala Ala 
        275                 280                 285             


Leu Lys Asp Trp Glu Lys Ala Pro Asp Gln Ala Asp Leu Thr Gly Gly 
    290                 295                 300                 


Ala Leu Asp Arg Ser Glu Leu Glu Arg Ser His Leu Met Leu Pro Leu 
305                 310                 315                 320 


Glu Arg Gly Trp Arg Lys Gln Lys Glu Gly Gly Pro Leu Ala Pro Gln 
                325                 330                 335     


Pro Lys Val Arg Leu Arg Gln Glu Val Val Ser Ala Ala Gly Pro Arg 
            340                 345                 350         


Arg Gly Gln Arg Ile Ala Val Pro Val Arg Lys Leu Phe Ala Arg Glu 
        355                 360                 365             


Lys Arg Pro Tyr Gly Leu Gly Met Val Gly Arg Leu Thr Asn Arg Thr 
    370                 375                 380                 


Tyr Arg Lys Arg Ile Asp Ser Tyr Val Lys Arg Gln Ile Glu Asp Met 
385                 390                 395                 400 


Asp Asp His Arg Pro Phe Phe Thr Tyr Trp Leu Thr Phe Val His Ser 
                405                 410                 415     


Leu Val Thr Ile Leu Ala Val Cys Ile Tyr Gly Ile Ala Pro Val Gly 
            420                 425                 430         


Phe Ser Gln His Glu Thr Val Asp Ser Val Leu Arg Lys Arg Gly Val 
        435                 440                 445             


Tyr Glu Asn Val Lys Tyr Val Gln Gln Glu Asn Phe Trp Ile Gly Pro 
    450                 455                 460                 


Ser Ser Glu Ala Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Met 
465                 470                 475                 480 


Arg Gln Asp Pro Gln Val His Ser Phe Ile Leu Ala Ala Arg Glu Arg 
                485                 490                 495     


Glu Lys His Ser Ala Cys Cys Val Arg Asn Asp Arg Ser Gly Cys Val 
            500                 505                 510         


Gln Thr Ser Lys Glu Glu Cys Ser Ser Thr Leu Ala Val Trp Val Lys 
        515                 520                 525             


Trp Pro Val His Pro Ser Ala Pro Asp Leu Ala Gly Asn Lys Arg Gln 
    530                 535                 540                 


Phe Gly Ser Val Cys His Gln Asp Pro Arg Val Cys Asp Glu Pro Ser 
545                 550                 555                 560 


Ser Glu Asp Pro His Glu Trp Pro Glu Asp Ile Thr Lys Trp Pro Ile 
                565                 570                 575     


Cys Thr Lys Ser Ser Ala Gly Asn His Thr Asn His Pro His Met Asp 
            580                 585                 590         


Cys Val Ile Thr Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Arg Cys 
        595                 600                 605             


Glu Ile Thr Ser Arg Glu Tyr Cys Asp Phe Met Arg Gly Tyr Phe His 
    610                 615                 620                 


Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys Met Asp Asp Val Cys 
625                 630                 635                 640 


Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg 
                645                 650                 655     


Leu Trp Leu Ser Leu Phe Leu His Ala Gly Ile Leu His Cys Leu Val 
            660                 665                 670         


Ser Val Cys Phe Gln Met Thr Val Leu Arg Asp Leu Glu Lys Leu Ala 
        675                 680                 685             


Gly Trp His Arg Ile Ala Ile Ile Tyr Leu Leu Ser Gly Ile Thr Gly 
    690                 695                 700                 


Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro 
705                 710                 715                 720 


Ala Gly Ser Gln Phe Gly Ile Leu Ala Cys Leu Phe Val Glu Leu Phe 
                725                 730                 735     


Gln Ser Trp Gln Ile Leu Ala Arg Pro Trp Arg Ala Phe Phe Lys Leu 
            740                 745                 750         


Leu Ala Val Val Leu Phe Leu Phe Ala Phe Gly Leu Leu Pro Trp Ile 
        755                 760                 765             


Asp Asn Phe Ala His Ile Ser Gly Phe Val Ser Gly Leu Phe Leu Ser 
    770                 775                 780                 


Phe Ala Phe Leu Pro Tyr Ile Ser Phe Gly Lys Phe Asp Leu Tyr Arg 
785                 790                 795                 800 


Lys Arg Cys Gln Ile Ile Ile Phe Gln Val Val Phe Leu Gly Leu Leu 
                805                 810                 815     


Ala Gly Leu Val Val Leu Phe Tyr Phe Tyr Pro Val Arg Cys Glu Trp 
            820                 825                 830         


Cys Glu Phe Leu Thr Cys Ile Pro Phe Thr Asp Lys Phe Cys Glu Lys 
        835                 840                 845             


Tyr Glu Leu Asp Ala Gln Leu His 
    850                 855     


<210>  4
<211>  584
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ser Thr Tyr Pro Asp Glu Val Phe Glu Ser Pro Ser Glu Ala Ala 
1               5                   10                  15      


Leu Lys Asp Trp Glu Lys Ala Pro Asp Gln Ala Asp Leu Thr Gly Gly 
            20                  25                  30          


Ala Leu Asp Arg Ser Glu Leu Glu Arg Ser His Leu Met Leu Pro Leu 
        35                  40                  45              


Glu Arg Gly Trp Arg Lys Gln Lys Glu Gly Gly Pro Leu Ala Pro Gln 
    50                  55                  60                  


Pro Lys Val Arg Leu Arg Gln Glu Val Val Ser Ala Ala Gly Pro Arg 
65                  70                  75                  80  


Arg Gly Gln Arg Ile Ala Val Pro Val Arg Lys Leu Phe Ala Arg Glu 
                85                  90                  95      


Lys Arg Pro Tyr Gly Leu Gly Met Val Gly Arg Leu Thr Asn Arg Thr 
            100                 105                 110         


Tyr Arg Lys Arg Ile Asp Ser Tyr Val Lys Arg Gln Ile Glu Asp Met 
        115                 120                 125             


Asp Asp His Arg Pro Phe Phe Thr Tyr Trp Leu Thr Phe Val His Ser 
    130                 135                 140                 


Leu Val Thr Ile Leu Ala Val Cys Ile Tyr Gly Ile Ala Pro Val Gly 
145                 150                 155                 160 


Phe Ser Gln His Glu Thr Val Asp Ser Val Leu Arg Lys Arg Gly Val 
                165                 170                 175     


Tyr Glu Asn Val Lys Tyr Val Gln Gln Glu Asn Phe Trp Ile Gly Pro 
            180                 185                 190         


Ser Ser Glu Ala Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Met 
        195                 200                 205             


Arg Gln Asp Pro Gln Val His Ser Phe Ile Leu Ala Ala Arg Glu Arg 
    210                 215                 220                 


Glu Lys His Ser Ala Cys Cys Val Arg Asn Asp Arg Ser Gly Cys Val 
225                 230                 235                 240 


Gln Thr Ser Lys Glu Glu Cys Ser Ser Thr Leu Ala Val Trp Val Lys 
                245                 250                 255     


Trp Pro Val His Pro Ser Ala Pro Asp Leu Ala Gly Asn Lys Arg Gln 
            260                 265                 270         


Phe Gly Ser Val Cys His Gln Asp Pro Arg Val Cys Asp Glu Pro Ser 
        275                 280                 285             


Ser Glu Asp Pro His Glu Trp Pro Glu Asp Ile Thr Lys Trp Pro Ile 
    290                 295                 300                 


Cys Thr Lys Ser Ser Ala Gly Asn His Thr Asn His Pro His Met Asp 
305                 310                 315                 320 


Cys Val Ile Thr Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Arg Cys 
                325                 330                 335     


Glu Ile Thr Ser Arg Glu Tyr Cys Asp Phe Met Arg Gly Tyr Phe His 
            340                 345                 350         


Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys Met Asp Asp Val Cys 
        355                 360                 365             


Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg 
    370                 375                 380                 


Leu Trp Leu Ser Leu Phe Leu His Ala Gly Ile Leu His Cys Leu Val 
385                 390                 395                 400 


Ser Val Cys Phe Gln Met Thr Val Leu Arg Asp Leu Glu Lys Leu Ala 
                405                 410                 415     


Gly Trp His Arg Ile Ala Ile Ile Tyr Leu Leu Ser Gly Ile Thr Gly 
            420                 425                 430         


Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro 
        435                 440                 445             


Ala Gly Ser Gln Phe Gly Ile Leu Ala Cys Leu Phe Val Glu Leu Phe 
    450                 455                 460                 


Gln Ser Trp Gln Ile Leu Ala Arg Pro Trp Arg Ala Phe Phe Lys Leu 
465                 470                 475                 480 


Leu Ala Val Val Leu Phe Leu Phe Ala Phe Gly Leu Leu Pro Trp Ile 
                485                 490                 495     


Asp Asn Phe Ala His Ile Ser Gly Phe Val Ser Gly Leu Phe Leu Ser 
            500                 505                 510         


Phe Ala Phe Leu Pro Tyr Ile Ser Phe Gly Lys Phe Asp Leu Tyr Arg 
        515                 520                 525             


Lys Arg Cys Gln Ile Ile Ile Phe Gln Val Val Phe Leu Gly Leu Leu 
    530                 535                 540                 


Ala Gly Leu Val Val Leu Phe Tyr Phe Tyr Pro Val Arg Cys Glu Trp 
545                 550                 555                 560 


Cys Glu Phe Leu Thr Cys Ile Pro Phe Thr Asp Lys Phe Cys Glu Lys 
                565                 570                 575     


Tyr Glu Leu Asp Ala Gln Leu His 
            580                 


<210>  5
<211>  856
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ser Ala Asp Lys Asn Gly Gly Ser Val Ser Ser Val Ser Ser 
1               5                   10                  15      


Ser Arg Leu Gln Ser Arg Lys Pro Pro Asn Leu Ser Ile Thr Ile Pro 
            20                  25                  30          


Pro Pro Glu Lys Glu Thr Gln Ala Pro Gly Glu Gln Asp Ser Met Leu 
        35                  40                  45              


Pro Glu Gly Phe Gln Asn Arg Arg Leu Lys Lys Ser Gln Pro Arg Thr 
    50                  55                  60                  


Trp Ala Ala His Thr Thr Ala Cys Pro Pro Ser Phe Leu Pro Lys Arg 
65                  70                  75                  80  


Lys Asn Pro Ala Tyr Leu Lys Ser Val Ser Leu Gln Glu Pro Arg Ser 
                85                  90                  95      


Arg Trp Gln Glu Ser Ser Glu Lys Arg Pro Gly Phe Arg Arg Gln Ala 
            100                 105                 110         


Ser Leu Ser Gln Ser Ile Arg Lys Gly Ala Ala Gln Trp Phe Gly Val 
        115                 120                 125             


Ser Gly Asp Trp Glu Gly Gln Arg Gln Gln Trp Gln Arg Arg Ser Leu 
    130                 135                 140                 


His His Cys Ser Met Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg 
145                 150                 155                 160 


Asp Leu Glu Leu Pro Ser Gln Glu Ala Pro Ser Phe Gln Gly Thr Glu 
                165                 170                 175     


Ser Pro Lys Pro Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
            180                 185                 190         


Gly Arg Ala Phe Arg His Pro Glu Glu Met Asp Arg Pro His Ala Pro 
        195                 200                 205             


His Pro Pro Leu Thr Pro Gly Val Leu Ser Leu Thr Ser Phe Thr Ser 
    210                 215                 220                 


Val Arg Ser Gly Tyr Ser His Leu Pro Arg Arg Lys Arg Met Ser Val 
225                 230                 235                 240 


Ala His Met Ser Leu Gln Ala Ala Ala Ala Leu Leu Lys Gly Arg Ser 
                245                 250                 255     


Val Leu Asp Ala Thr Gly Gln Arg Cys Arg Val Val Lys Arg Ser Phe 
            260                 265                 270         


Ala Phe Pro Ser Phe Leu Glu Glu Asp Val Val Asp Gly Ala Asp Thr 
        275                 280                 285             


Phe Asp Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met Pro Asp 
    290                 295                 300                 


Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg Gly Ile 
305                 310                 315                 320 


Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val Gln Ile Pro Leu 
                325                 330                 335     


Lys Glu Tyr Gly Arg Ala Pro Val Pro Gly Pro Arg Arg Gly Lys Arg 
            340                 345                 350         


Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg Lys Lys Arg His 
        355                 360                 365             


Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg Ser Tyr Arg Arg 
    370                 375                 380                 


Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser Phe Asp Ser His 
385                 390                 395                 400 


Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His Val Ile Ile Thr 
                405                 410                 415     


Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val Gly Phe Ala Gln 
            420                 425                 430         


His Val Thr Thr Gln Leu Val Leu Arg Asn Lys Gly Val Tyr Glu Ser 
        435                 440                 445             


Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Val Gly Pro Ser Ser Ile 
    450                 455                 460                 


Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Ile Arg Lys Asp 
465                 470                 475                 480 


Gly Gln Ile Glu Gln Leu Val Leu Arg Glu Arg Asp Leu Glu Arg Asp 
                485                 490                 495     


Ser Gly Cys Cys Val Gln Asn Asp His Ser Gly Cys Ile Gln Thr Gln 
            500                 505                 510         


Arg Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val Lys Trp Gln Asp 
        515                 520                 525             


Asp Thr Gly Pro Pro Met Asp Lys Ser Asp Leu Gly Gln Lys Arg Thr 
    530                 535                 540                 


Ser Gly Ala Val Cys His Gln Asp Pro Arg Thr Cys Glu Glu Pro Ala 
545                 550                 555                 560 


Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys Trp Pro Ile 
                565                 570                 575     


Cys Thr Glu Gln Ala Arg Ser Asn His Thr Gly Phe Leu His Met Asp 
            580                 585                 590         


Cys Glu Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Ser Cys 
        595                 600                 605             


Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly Tyr Phe His 
    610                 615                 620                 


Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp Lys Val Cys 
625                 630                 635                 640 


Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg 
                645                 650                 655     


Leu Trp Leu Ser Leu Phe Leu His Ala Gly Val Val His Cys Leu Val 
            660                 665                 670         


Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu Lys Leu Ala 
        675                 680                 685             


Gly Trp His Arg Ile Ala Ile Ile Phe Ile Leu Ser Gly Ile Thr Gly 
    690                 695                 700                 


Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro 
705                 710                 715                 720 


Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val Glu Leu Phe 
                725                 730                 735     


Gln Ser Trp Pro Leu Leu Glu Arg Pro Trp Lys Ala Phe Leu Asn Leu 
            740                 745                 750         


Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu Pro Trp Ile 
        755                 760                 765             


Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Leu Leu Leu Ala 
    770                 775                 780                 


Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp Lys Tyr Arg 
785                 790                 795                 800 


Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Ala Phe Ala Gly Leu Phe 
                805                 810                 815     


Ala Ala Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn Trp Pro Trp 
            820                 825                 830         


Ile Glu His Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe Cys Glu Lys 
        835                 840                 845             


Tyr Glu Leu Asp Gln Val Leu His 
    850                 855     


<210>  6
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Ser Met Pro Asp Asp Val Phe Glu Ser Pro Pro Leu Ser Ala 
1               5                   10                  15      


Ser Tyr Phe Arg Gly Ile Pro His Ser Ala Ser Pro Val Ser Pro Asp 
            20                  25                  30          


Gly Val Gln Ile Pro Leu Lys Glu Tyr Gly Arg Ala Pro Val Pro Gly 
        35                  40                  45              


Pro Arg Arg Gly Lys Arg Ile Ala Ser Lys Val Lys His Phe Ala Phe 
    50                  55                  60                  


Asp Arg Lys Lys Arg His Tyr Gly Leu Gly Val Val Gly Asn Trp Leu 
65                  70                  75                  80  


Asn Arg Ser Tyr Arg Arg Ser Ile Ser Ser Thr Val Gln Arg Gln Leu 
                85                  90                  95      


Glu Ser Phe Asp Ser His Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe 
            100                 105                 110         


Val His Val Ile Ile Thr Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala 
        115                 120                 125             


Pro Val Gly Phe Ala Gln His Val Thr Thr Gln Leu Val Leu Arg Asn 
    130                 135                 140                 


Lys Gly Val Tyr Glu Ser Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp 
145                 150                 155                 160 


Val Gly Pro Ser Ser Ile Asp Leu Ile His Leu Gly Ala Lys Phe Ser 
                165                 170                 175     


Pro Cys Ile Arg Lys Asp Gly Gln Ile Glu Gln Leu Val Leu Arg Glu 
            180                 185                 190         


Arg Asp Leu Glu Arg Asp Ser Gly Cys Cys Val Gln Asn Asp His Ser 
        195                 200                 205             


Gly Cys Ile Gln Thr Gln Arg Lys Asp Cys Ser Glu Thr Leu Ala Thr 
    210                 215                 220                 


Phe Val Lys Trp Gln Asp Asp Thr Gly Pro Pro Met Asp Lys Ser Asp 
225                 230                 235                 240 


Leu Gly Gln Lys Arg Thr Ser Gly Ala Val Cys His Gln Asp Pro Arg 
                245                 250                 255     


Thr Cys Glu Glu Pro Ala Ser Ser Gly Ala His Ile Trp Pro Asp Asp 
            260                 265                 270         


Ile Thr Lys Trp Pro Ile Cys Thr Glu Gln Ala Arg Ser Asn His Thr 
        275                 280                 285             


Gly Phe Leu His Met Asp Cys Glu Ile Lys Gly Arg Pro Cys Cys Ile 
    290                 295                 300                 


Gly Thr Lys Gly Ser Cys Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe 
305                 310                 315                 320 


Met His Gly Tyr Phe His Glu Glu Ala Thr Leu Cys Ser Gln Val His 
                325                 330                 335     


Cys Leu Asp Lys Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu Val 
            340                 345                 350         


Pro Asp Gln Phe Tyr Arg Leu Trp Leu Ser Leu Phe Leu His Ala Gly 
        355                 360                 365             


Val Val His Cys Leu Val Ser Val Val Phe Gln Met Thr Ile Leu Arg 
    370                 375                 380                 


Asp Leu Glu Lys Leu Ala Gly Trp His Arg Ile Ala Ile Ile Phe Ile 
385                 390                 395                 400 


Leu Ser Gly Ile Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr 
                405                 410                 415     


Arg Ala Glu Val Gly Pro Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys 
            420                 425                 430         


Leu Phe Val Glu Leu Phe Gln Ser Trp Pro Leu Leu Glu Arg Pro Trp 
        435                 440                 445             


Lys Ala Phe Leu Asn Leu Ser Ala Ile Val Leu Phe Leu Phe Ile Cys 
    450                 455                 460                 


Gly Leu Leu Pro Trp Ile Asp Asn Ile Ala His Ile Phe Gly Phe Leu 
465                 470                 475                 480 


Ser Gly Leu Leu Leu Ala Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly 
                485                 490                 495     


Thr Ser Asp Lys Tyr Arg Lys Arg Ala Leu Ile Leu Val Ser Leu Leu 
            500                 505                 510         


Ala Phe Ala Gly Leu Phe Ala Ala Leu Val Leu Trp Leu Tyr Ile Tyr 
        515                 520                 525             


Pro Ile Asn Trp Pro Trp Ile Glu His Leu Thr Cys Phe Pro Phe Thr 
    530                 535                 540                 


Ser Arg Phe Cys Glu Lys Tyr Glu Leu Asp Gln Val Leu His 
545                 550                 555             


<210>  7
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Glu Ala Arg Arg Asp Ser Thr Ser Ser Leu Gln Arg Lys Lys 
1               5                   10                  15      


Pro Pro Trp Leu Lys Leu Asp Ile Pro Ser Ala Val Pro Leu Thr Ala 
            20                  25                  30          


Glu Glu Pro Ser Phe Leu Gln Pro Leu Arg Arg Gln Ala Phe Leu Arg 
        35                  40                  45              


Ser Val Ser Met Pro Ala Glu Thr Ala His Ile Ser Ser Pro His His 
    50                  55                  60                  


Glu Leu Arg Arg Pro Val Leu Gln Arg Gln Thr Ser Ile Thr Gln Thr 
65                  70                  75                  80  


Ile Arg Arg Gly Thr Ala Asp Trp Phe Gly Val Ser Lys Asp Ser Asp 
                85                  90                  95      


Ser Thr Gln Lys Trp Gln Arg Lys Ser Ile Arg His Cys Ser Gln Arg 
            100                 105                 110         


Tyr Gly Lys Leu Lys Pro Gln Val Leu Arg Glu Leu Asp Leu Pro Ser 
        115                 120                 125             


Gln Asp Asn Val Ser Leu Thr Ser Thr Glu Thr Pro Pro Pro Leu Tyr 
    130                 135                 140                 


Val Gly Pro Cys Gln Leu Gly Met Gln Lys Ile Ile Asp Pro Leu Ala 
145                 150                 155                 160 


Arg Gly Arg Ala Phe Arg Val Ala Asp Asp Thr Ala Glu Gly Leu Ser 
                165                 170                 175     


Ala Pro His Thr Pro Val Thr Pro Gly Ala Ala Ser Leu Cys Ser Phe 
            180                 185                 190         


Ser Ser Ser Arg Ser Gly Phe His Arg Leu Pro Arg Arg Arg Lys Arg 
        195                 200                 205             


Glu Ser Val Ala Lys Met Ser Phe Arg Ala Ala Ala Ala Leu Met Lys 
    210                 215                 220                 


Gly Arg Ser Val Arg Asp Gly Thr Phe Arg Arg Ala Gln Arg Arg Ser 
225                 230                 235                 240 


Phe Thr Pro Ala Ser Phe Leu Glu Glu Asp Thr Thr Asp Phe Pro Asp 
                245                 250                 255     


Glu Leu Asp Thr Ser Phe Phe Ala Arg Glu Gly Ile Leu His Glu Glu 
            260                 265                 270         


Leu Ser Thr Tyr Pro Asp Glu Val Phe Glu Ser Pro Ser Glu Ala Ala 
        275                 280                 285             


Leu Lys Asp Trp Glu Lys Ala Pro Glu Gln Ala Asp Leu Thr Gly Gly 
    290                 295                 300                 


Ala Leu Asp Arg Ser Glu Leu Glu Arg Ser His Leu Met Leu Pro Leu 
305                 310                 315                 320 


Glu Arg Gly Trp Arg Lys Gln Lys Glu Gly Ala Ala Ala Pro Gln Pro 
                325                 330                 335     


Lys Val Arg Leu Arg Gln Glu Val Val Ser Thr Ala Gly Pro Arg Arg 
            340                 345                 350         


Gly Gln Arg Ile Ala Val Pro Val Arg Lys Leu Phe Ala Arg Glu Lys 
        355                 360                 365             


Arg Pro Tyr Gly Leu Gly Met Val Gly Arg Leu Thr Asn Arg Thr Tyr 
    370                 375                 380                 


Arg Lys Arg Ile Asp Ser Phe Val Lys Arg Gln Ile Glu Asp Met Asp 
385                 390                 395                 400 


Asp His Arg Pro Phe Phe Thr Tyr Trp Leu Thr Phe Val His Ser Leu 
                405                 410                 415     


Val Thr Ile Leu Ala Val Cys Ile Tyr Gly Ile Ala Pro Val Gly Phe 
            420                 425                 430         


Ser Gln His Glu Thr Val Asp Ser Val Leu Arg Asn Arg Gly Val Tyr 
        435                 440                 445             


Glu Asn Val Lys Tyr Val Gln Gln Glu Asn Phe Trp Ile Gly Pro Ser 
    450                 455                 460                 


Ser Glu Ala Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Met Arg 
465                 470                 475                 480 


Gln Asp Pro Gln Val His Ser Phe Ile Arg Ser Ala Arg Glu Arg Glu 
                485                 490                 495     


Lys His Ser Ala Cys Cys Val Arg Asn Asp Arg Ser Gly Cys Val Gln 
            500                 505                 510         


Thr Ser Glu Glu Glu Cys Ser Ser Thr Leu Ala Val Trp Val Lys Trp 
        515                 520                 525             


Pro Ile His Pro Ser Ala Pro Glu Leu Ala Gly His Lys Arg Gln Phe 
    530                 535                 540                 


Gly Ser Val Cys His Gln Asp Pro Arg Val Cys Asp Glu Pro Ser Ser 
545                 550                 555                 560 


Glu Asp Pro His Glu Trp Pro Glu Asp Ile Thr Lys Trp Pro Ile Cys 
                565                 570                 575     


Thr Lys Asn Ser Ala Gly Asn His Thr Asn His Pro His Met Asp Cys 
            580                 585                 590         


Val Ile Thr Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Arg Cys Glu 
        595                 600                 605             


Ile Thr Ser Arg Glu Tyr Cys Asp Phe Met Arg Gly Tyr Phe His Glu 
    610                 615                 620                 


Glu Ala Thr Leu Cys Ser Gln Val His Cys Met Asp Asp Val Cys Gly 
625                 630                 635                 640 


Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg Leu 
                645                 650                 655     


Trp Leu Ser Leu Phe Leu His Ala Gly Ile Leu His Cys Leu Val Ser 
            660                 665                 670         


Ile Cys Phe Gln Met Thr Val Leu Arg Asp Leu Glu Lys Leu Ala Gly 
        675                 680                 685             


Trp His Arg Ile Ala Ile Ile Tyr Leu Leu Ser Gly Val Thr Gly Asn 
    690                 695                 700                 


Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Ser Gln Phe Gly Ile Leu Ala Cys Leu Phe Val Glu Leu Phe Gln 
                725                 730                 735     


Ser Trp Gln Ile Leu Ala Arg Pro Trp Arg Ala Phe Phe Lys Leu Leu 
            740                 745                 750         


Ala Val Val Leu Phe Leu Phe Thr Phe Gly Leu Leu Pro Trp Ile Asp 
        755                 760                 765             


Asn Phe Ala His Ile Ser Gly Phe Ile Ser Gly Leu Phe Leu Ser Phe 
    770                 775                 780                 


Ala Phe Leu Pro Tyr Ile Ser Phe Gly Lys Phe Asp Leu Tyr Arg Lys 
785                 790                 795                 800 


Arg Cys Gln Ile Ile Ile Phe Gln Val Val Phe Leu Gly Leu Leu Ala 
                805                 810                 815     


Gly Leu Val Val Leu Phe Tyr Val Tyr Pro Val Arg Cys Glu Trp Cys 
            820                 825                 830         


Glu Phe Leu Thr Cys Ile Pro Phe Thr Asp Lys Phe Cys Glu Lys Tyr 
        835                 840                 845             


Glu Leu Asp Ala Gln Leu His 
    850                 855 


<210>  8
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Pro Leu Glu Arg Gly Trp Arg Lys Gln Lys Glu Gly Ala Ala 
1               5                   10                  15      


Ala Pro Gln Pro Lys Val Arg Leu Arg Gln Glu Val Val Ser Thr Ala 
            20                  25                  30          


Gly Pro Arg Arg Gly Gln Arg Ile Ala Val Pro Val Arg Lys Leu Phe 
        35                  40                  45              


Ala Arg Glu Lys Arg Pro Tyr Gly Leu Gly Met Val Gly Arg Leu Thr 
    50                  55                  60                  


Asn Arg Thr Tyr Arg Lys Arg Ile Asp Ser Phe Val Lys Arg Gln Ile 
65                  70                  75                  80  


Glu Asp Met Asp Asp His Arg Pro Phe Phe Thr Tyr Trp Leu Thr Phe 
                85                  90                  95      


Val His Ser Leu Val Thr Ile Leu Ala Val Cys Ile Tyr Gly Ile Ala 
            100                 105                 110         


Pro Val Gly Phe Ser Gln His Glu Thr Val Asp Ser Val Leu Arg Asn 
        115                 120                 125             


Arg Gly Val Tyr Glu Asn Val Lys Tyr Val Gln Gln Glu Asn Phe Trp 
    130                 135                 140                 


Ile Gly Pro Ser Ser Glu Ala Leu Ile His Leu Gly Ala Lys Phe Ser 
145                 150                 155                 160 


Pro Cys Met Arg Gln Asp Pro Gln Val His Ser Phe Ile Arg Ser Ala 
                165                 170                 175     


Arg Glu Arg Glu Lys His Ser Ala Cys Cys Val Arg Asn Asp Arg Ser 
            180                 185                 190         


Gly Cys Val Gln Thr Ser Glu Glu Glu Cys Ser Ser Thr Leu Ala Val 
        195                 200                 205             


Trp Val Lys Trp Pro Ile His Pro Ser Ala Pro Glu Leu Ala Gly His 
    210                 215                 220                 


Lys Arg Gln Phe Gly Ser Val Cys His Gln Asp Pro Arg Val Cys Asp 
225                 230                 235                 240 


Glu Pro Ser Ser Glu Asp Pro His Glu Trp Pro Glu Asp Ile Thr Lys 
                245                 250                 255     


Trp Pro Ile Cys Thr Lys Asn Ser Ala Gly Asn His Thr Asn His Pro 
            260                 265                 270         


His Met Asp Cys Val Ile Thr Gly Arg Pro Cys Cys Ile Gly Thr Lys 
        275                 280                 285             


Gly Arg Cys Glu Ile Thr Ser Arg Glu Tyr Cys Asp Phe Met Arg Gly 
    290                 295                 300                 


Tyr Phe His Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys Met Asp 
305                 310                 315                 320 


Asp Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln 
                325                 330                 335     


Phe Tyr Arg Leu Trp Leu Ser Leu Phe Leu His Ala Gly Ile Leu His 
            340                 345                 350         


Cys Leu Val Ser Ile Cys Phe Gln Met Thr Val Leu Arg Asp Leu Glu 
        355                 360                 365             


Lys Leu Ala Gly Trp His Arg Ile Ala Ile Ile Tyr Leu Leu Ser Gly 
    370                 375                 380                 


Val Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu 
385                 390                 395                 400 


Val Gly Pro Ala Gly Ser Gln Phe Gly Ile Leu Ala Cys Leu Phe Val 
                405                 410                 415     


Glu Leu Phe Gln Ser Trp Gln Ile Leu Ala Arg Pro Trp Arg Ala Phe 
            420                 425                 430         


Phe Lys Leu Leu Ala Val Val Leu Phe Leu Phe Thr Phe Gly Leu Leu 
        435                 440                 445             


Pro Trp Ile Asp Asn Phe Ala His Ile Ser Gly Phe Ile Ser Gly Leu 
    450                 455                 460                 


Phe Leu Ser Phe Ala Phe Leu Pro Tyr Ile Ser Phe Gly Lys Phe Asp 
465                 470                 475                 480 


Leu Tyr Arg Lys Arg Cys Gln Ile Ile Ile Phe Gln Val Val Phe Leu 
                485                 490                 495     


Gly Leu Leu Ala Gly Leu Val Val Leu Phe Tyr Val Tyr Pro Val Arg 
            500                 505                 510         


Cys Glu Trp Cys Glu Phe Leu Thr Cys Ile Pro Phe Thr Asp Lys Phe 
        515                 520                 525             


Cys Glu Lys Tyr Glu Leu Asp Ala Gln Leu His 
    530                 535                 


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  9
aaaaccctcc acccttcc                                                     18


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  10
cggggaacaa ctctgaatcc                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  11
agagccactt tgggtctgtc                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  12
acgcaacgtt ctgtcaaaag                                                   20


<210>  13
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  13
tgtattgaac atgtattatg aagttgg                                           27


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  14
caactgtgct gtgtgcatcc                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  15
ccttgtgcct tagcaaatgt                                                   20


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  16
agacacacac atcaacaata ggg                                               23


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  17
tccatcacca tcaacacaca g                                                 21


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  18
ccctgaaatt ccataaggac ag                                                22


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  19
tcaatcaagt ccaagtaatg cc                                                22


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  20
attccacatg ctgttgttcc                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  21
tcacacttgg tatccatcgc                                                   20


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  22
aaaagaaata agcccatggt tc                                                22


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  23
ctagtaagtc ctcgcgtgcc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  24
gtcctatgac aaatgcaccg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  25
aacgaaagtt gctttcctgg                                                   20


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  26
ttcattggca tgtacttata ttgac                                             25


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  27
gctatacagc cagagtccca g                                                 21


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  28
cagaagaggc gaggaaagtg                                                   20


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  29
ggtttcttat attgcagtgg gg                                                22


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  30
cgcagattcc actttgttcc                                                   20


<210>  31
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  31
tgtctgggca ttttacataa gc                                                22


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  32
tgtgccaagc cataattcag                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  33
tgacattcct gcgagcttag                                                   20


<210>  34
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  34
caagatctgg ttagcgccc                                                    19


<210>  35
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  35
tctgaagaca aatttgaacc cc                                                22


<210>  36
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  36
ttccatgggt atggataatg aag                                               23


<210>  37
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  37
ggtgcccaga ttcaaaatg                                                    19


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  38
tagtgcacca gaatgccttg                                                   20


<210>  39
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  39
aagtgccaag ggaccaatc                                                    19


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  40
taccccaagg ttcttgcatc                                                   20


<210>  41
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  41
gaaaacaggc gttttagata ttgg                                              24


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  42
cacggagtgg atctactgga c                                                 21


<210>  43
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  43
cactatactg agaaccaaag caacc                                             25


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  44
aagtgctgtt tatgctcccc                                                   20


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  45
caaatttgtc acgtttggtt c                                                 21


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  46
ccgacactac tttcaagccc                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  47
tccagcgggt ctataaaagc                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  48
gacgtttggg gaatgtcaag                                                   20


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  49
tgtctacaca gcaatgctca c                                                 21


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  50
ctttgcagag gtaaaacccg                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  51
aaaagagaac gtgggcagtc                                                   20


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  52
ccttggttta cacactggaa aag                                               23


<210>  53
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  53
gtatgtttga gatgcagaaa acc                                               23


<210>  54
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  54
tgacagtaga gtctgatagg aatactg                                           27


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  55
gtcacaggag gaaagtcccc                                                   20


<210>  56
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  56
cttcttttgc cttgagataa gtg                                               23


<210>  57
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  57
tggtggtttt ctataagaat atttagc                                           27


<210>  58
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  58
aagcccttgt aaatgattgt cc                                                22


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  59
aaggttcaca ggactccagc                                                   20


<210>  60
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  60
aagtggtgtg cctctccg                                                     18


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  61
aaaaggatta agcatttggg g                                                 21


<210>  62
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  62
tgggtcatga cactaaaagg ac                                                22


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  63
tttccaatgc tgtcaaaccc                                                   20


<210>  64
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  64
gaatcaatga ataaaacggg g                                                 21


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  65
tgggaagagg agaaaagcaa g                                                 21


<210>  66
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  66
gaaaacagtg ctaattactt ccaaag                                            26


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  67
attagacatg gtgaagcccc                                                   20


<210>  68
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  68
tttgcatact gacaggaact cac                                               23


<210>  69
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  69
tgctgagcag acagtcacg                                                    19


<210>  70
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  70
ttgggctcat gtgcgag                                                      17


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  71
tgctttggtc agtcaaccag                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  72
ttttcccact cttgtggtcc                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  73
ttcccattgg ctgctgtaag                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  74
ccaactgaac cacactttgc                                                   20


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  75
tccatgaagt caatcctgaa g                                                 21


<210>  76
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  76
gaggcaggca aatctctgtg                                                   20


<210>  77
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  77
tggttggttg gttggttagg                                                   20


<210>  78
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  78
tgaagcacaa aagccaactc                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  79
cggtggaacc aatgagaact                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  80
ctcaccctcc tagcatgagc                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  81
cggtggaacc aatgagaact                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  82
gtcgtagtcc cctgtggaga                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  83
cggtggaacc aatgagaact                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  84
ttgcctccct ttttcttcct                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  85
cggtggaacc aatgagaact                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  86
ccacaccgtt caccaaagta                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  87
gttgctgcag agaccgagac                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  88
gtcgtagtcc cctgtggaga                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  89
ctggcagtga actctccaca                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR PRIMER

<400>  90
ccacaccgtt caccaaagta                                                   20


