                         SEQUENCE LISTING

<110>  The University of York
       GLAXOSMITHKLINE AUSTRALIA PTY LIMITED
 
<120>  Novel Cytochrome P450 Fusion Protein

<130>  4419P/WO

<150>  GB1408729.0
<151>  2014-05-16

<150>  GB1506805.9
<151>  2015-04-22

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  901
<212>  PRT
<213>  Papaver somniferum

<400>  1

Met Glu Leu Gln Tyr Ile Ser Tyr Phe Gln Pro Thr Ser Ser Val Val 
1               5                   10                  15      


Ala Leu Leu Leu Ala Leu Val Ser Ile Leu Ser Ser Val Val Val Leu 
            20                  25                  30          


Arg Lys Thr Phe Leu Asn Asn Tyr Ser Ser Ser Pro Ala Ser Ser Thr 
        35                  40                  45              


Lys Thr Ala Val Leu Ser His Gln Arg Gln Gln Ser Cys Ala Leu Pro 
    50                  55                  60                  


Ile Ser Gly Leu Leu His Ile Phe Met Asn Lys Asn Gly Leu Ile His 
65                  70                  75                  80  


Val Thr Leu Gly Asn Met Ala Asp Lys Tyr Gly Pro Ile Phe Ser Phe 
                85                  90                  95      


Pro Thr Gly Ser His Arg Thr Leu Val Val Ser Ser Trp Glu Met Val 
            100                 105                 110         


Lys Glu Cys Phe Thr Gly Asn Asn Asp Thr Ala Phe Ser Asn Arg Pro 
        115                 120                 125             


Ile Pro Leu Ala Phe Lys Thr Ile Phe Tyr Ala Cys Gly Gly Ile Asp 
    130                 135                 140                 


Ser Tyr Gly Leu Ser Ser Val Pro Tyr Gly Lys Tyr Trp Arg Glu Leu 
145                 150                 155                 160 


Arg Lys Val Cys Val His Asn Leu Leu Ser Asn Gln Gln Leu Leu Lys 
                165                 170                 175     


Phe Arg His Leu Ile Ile Ser Gln Val Asp Thr Ser Phe Asn Lys Leu 
            180                 185                 190         


Tyr Glu Leu Cys Lys Asn Ser Glu Asp Asn His Gly Asn Tyr Thr Thr 
        195                 200                 205             


Thr Thr Thr Thr Ala Ala Gly Met Val Arg Ile Asp Asp Trp Leu Ala 
    210                 215                 220                 


Glu Leu Ser Phe Asn Val Ile Gly Arg Ile Val Cys Gly Phe Gln Ser 
225                 230                 235                 240 


Gly Pro Lys Thr Gly Ala Pro Ser Arg Val Glu Gln Phe Lys Glu Ala 
                245                 250                 255     


Ile Asn Glu Ala Ser Tyr Phe Met Ser Thr Ser Pro Val Ser Asp Asn 
            260                 265                 270         


Val Pro Met Leu Gly Trp Ile Asp Gln Leu Thr Gly Leu Thr Arg Asn 
        275                 280                 285             


Met Lys His Cys Gly Lys Lys Leu Asp Leu Val Val Glu Ser Ile Ile 
    290                 295                 300                 


Asn Asp His Arg Gln Lys Arg Arg Phe Ser Arg Thr Lys Gly Gly Asp 
305                 310                 315                 320 


Glu Lys Asp Asp Glu Gln Asp Asp Phe Ile Asp Ile Cys Leu Ser Ile 
                325                 330                 335     


Met Glu Gln Pro Gln Leu Pro Gly Asn Asn Asn Pro Ser Gln Ile Pro 
            340                 345                 350         


Ile Lys Ser Ile Val Leu Asp Met Ile Gly Gly Gly Thr Asp Thr Thr 
        355                 360                 365             


Lys Leu Thr Thr Ile Trp Thr Leu Ser Leu Leu Leu Asn Asn Pro His 
    370                 375                 380                 


Val Leu Asp Lys Ala Lys Gln Glu Val Asp Ala His Phe Arg Thr Lys 
385                 390                 395                 400 


Arg Arg Ser Thr Asn Asp Ala Ala Ala Ala Val Val Asp Phe Asp Asp 
                405                 410                 415     


Ile Arg Asn Leu Val Tyr Ile Gln Ala Ile Ile Lys Glu Ser Met Arg 
            420                 425                 430         


Leu Tyr Pro Ala Ser Pro Val Val Glu Arg Leu Ser Gly Glu Asp Cys 
        435                 440                 445             


Val Val Gly Gly Phe His Val Pro Ala Gly Thr Arg Leu Trp Ala Asn 
    450                 455                 460                 


Val Trp Lys Met Gln Arg Asp Pro Lys Val Trp Asp Asp Pro Leu Val 
465                 470                 475                 480 


Phe Arg Pro Asp Arg Phe Leu Ser Asp Glu Gln Lys Met Val Asp Val 
                485                 490                 495     


Arg Gly Gln Asn Tyr Glu Leu Leu Pro Phe Gly Ala Gly Arg Arg Val 
            500                 505                 510         


Cys Pro Gly Val Ser Phe Ser Leu Asp Leu Met Gln Leu Val Leu Thr 
        515                 520                 525             


Arg Leu Ile Leu Glu Phe Glu Met Lys Ser Pro Ser Gly Lys Val Asp 
    530                 535                 540                 


Met Thr Ala Thr Pro Gly Leu Met Ser Tyr Lys Val Ile Pro Leu Asp 
545                 550                 555                 560 


Ile Leu Leu Thr His Arg Arg Ile Lys Pro Cys Val Gln Ser Ala Ala 
                565                 570                 575     


Ser Glu Arg Asp Met Glu Ser Ser Gly Val Pro Val Ile Thr Leu Gly 
            580                 585                 590         


Ser Gly Lys Val Met Pro Val Leu Gly Met Gly Thr Phe Glu Lys Val 
        595                 600                 605             


Gly Lys Gly Ser Glu Arg Glu Arg Leu Ala Ile Leu Lys Ala Ile Glu 
    610                 615                 620                 


Val Gly Tyr Arg Tyr Phe Asp Thr Ala Ala Ala Tyr Glu Thr Glu Glu 
625                 630                 635                 640 


Val Leu Gly Glu Ala Ile Ala Glu Ala Leu Gln Leu Gly Leu Val Lys 
                645                 650                 655     


Ser Arg Asp Glu Leu Phe Ile Ser Ser Met Leu Trp Cys Thr Asp Ala 
            660                 665                 670         


His Ala Asp Arg Val Leu Leu Ala Leu Gln Asn Ser Leu Arg Asn Leu 
        675                 680                 685             


Lys Leu Glu Tyr Val Asp Leu Tyr Met Leu Pro Phe Pro Ala Ser Leu 
    690                 695                 700                 


Lys Pro Gly Lys Ile Thr Met Asp Ile Pro Glu Glu Asp Ile Cys Arg 
705                 710                 715                 720 


Met Asp Tyr Arg Ser Val Trp Ala Ala Met Glu Glu Cys Gln Asn Leu 
                725                 730                 735     


Gly Phe Thr Lys Ser Ile Gly Val Ser Asn Phe Ser Cys Lys Lys Leu 
            740                 745                 750         


Gln Glu Leu Met Ala Thr Ala Asn Ile Pro Pro Ala Val Asn Gln Val 
        755                 760                 765             


Glu Met Ser Pro Ala Phe Gln Gln Lys Lys Leu Arg Glu Tyr Cys Asn 
    770                 775                 780                 


Ala Asn Asn Ile Leu Val Ser Ala Ile Ser Val Leu Gly Ser Asn Gly 
785                 790                 795                 800 


Thr Pro Trp Gly Ser Asn Ala Val Leu Gly Ser Glu Val Leu Lys Lys 
                805                 810                 815     


Ile Ala Met Ala Lys Gly Lys Ser Val Ala Gln Val Ser Met Arg Trp 
            820                 825                 830         


Val Tyr Glu Gln Gly Ala Ser Leu Val Val Lys Ser Phe Ser Glu Glu 
        835                 840                 845             


Arg Leu Arg Glu Asn Leu Asn Ile Phe Asp Trp Glu Leu Thr Lys Glu 
    850                 855                 860                 


Asp His Glu Lys Ile Gly Glu Ile Pro Gln Cys Arg Ile Leu Ser Ala 
865                 870                 875                 880 


Tyr Phe Leu Val Ser Pro Asn Gly Pro Phe Lys Ser Gln Glu Glu Leu 
                885                 890                 895     


Trp Asp Asp Glu Ala 
            900     


<210>  2
<211>  580
<212>  PRT
<213>  Papaver somniferum

<400>  2

Met Glu Leu Gln Tyr Ile Ser Tyr Phe Gln Pro Thr Ser Ser Val Val 
1               5                   10                  15      


Ala Leu Leu Leu Ala Leu Val Ser Ile Leu Ser Ser Val Val Val Leu 
            20                  25                  30          


Arg Lys Thr Phe Leu Asn Asn Tyr Ser Ser Ser Pro Ala Ser Ser Thr 
        35                  40                  45              


Lys Thr Ala Val Leu Ser His Gln Arg Gln Gln Ser Cys Ala Leu Pro 
    50                  55                  60                  


Ile Ser Gly Leu Leu His Ile Phe Met Asn Lys Asn Gly Leu Ile His 
65                  70                  75                  80  


Val Thr Leu Gly Asn Met Ala Asp Lys Tyr Gly Pro Ile Phe Ser Phe 
                85                  90                  95      


Pro Thr Gly Ser His Arg Thr Leu Val Val Ser Ser Trp Glu Met Val 
            100                 105                 110         


Lys Glu Cys Phe Thr Gly Asn Asn Asp Thr Ala Phe Ser Asn Arg Pro 
        115                 120                 125             


Ile Pro Leu Ala Phe Lys Thr Ile Phe Tyr Ala Cys Gly Gly Ile Asp 
    130                 135                 140                 


Ser Tyr Gly Leu Ser Ser Val Pro Tyr Gly Lys Tyr Trp Arg Glu Leu 
145                 150                 155                 160 


Arg Lys Val Cys Val His Asn Leu Leu Ser Asn Gln Gln Leu Leu Lys 
                165                 170                 175     


Phe Arg His Leu Ile Ile Ser Gln Val Asp Thr Ser Phe Asn Lys Leu 
            180                 185                 190         


Tyr Glu Leu Cys Lys Asn Ser Glu Asp Asn His Gly Asn Tyr Thr Thr 
        195                 200                 205             


Thr Thr Thr Thr Ala Ala Gly Met Val Arg Ile Asp Asp Trp Leu Ala 
    210                 215                 220                 


Glu Leu Ser Phe Asn Val Ile Gly Arg Ile Val Cys Gly Phe Gln Ser 
225                 230                 235                 240 


Gly Pro Lys Thr Gly Ala Pro Ser Arg Val Glu Gln Phe Lys Glu Ala 
                245                 250                 255     


Ile Asn Glu Ala Ser Tyr Phe Met Ser Thr Ser Pro Val Ser Asp Asn 
            260                 265                 270         


Val Pro Met Leu Gly Trp Ile Asp Gln Leu Thr Gly Leu Thr Arg Asn 
        275                 280                 285             


Met Lys His Cys Gly Lys Lys Leu Asp Leu Val Val Glu Ser Ile Ile 
    290                 295                 300                 


Asn Asp His Arg Gln Lys Arg Arg Phe Ser Arg Thr Lys Gly Gly Asp 
305                 310                 315                 320 


Glu Lys Asp Asp Glu Gln Asp Asp Phe Ile Asp Ile Cys Leu Ser Ile 
                325                 330                 335     


Met Glu Gln Pro Gln Leu Pro Gly Asn Asn Asn Pro Ser Gln Ile Pro 
            340                 345                 350         


Ile Lys Ser Ile Val Leu Asp Met Ile Gly Gly Gly Thr Asp Thr Thr 
        355                 360                 365             


Lys Leu Thr Thr Ile Trp Thr Leu Ser Leu Leu Leu Asn Asn Pro His 
    370                 375                 380                 


Val Leu Asp Lys Ala Lys Gln Glu Val Asp Ala His Phe Arg Thr Lys 
385                 390                 395                 400 


Arg Arg Ser Thr Asn Asp Ala Ala Ala Ala Val Val Asp Phe Asp Asp 
                405                 410                 415     


Ile Arg Asn Leu Val Tyr Ile Gln Ala Ile Ile Lys Glu Ser Met Arg 
            420                 425                 430         


Leu Tyr Pro Ala Ser Pro Val Val Glu Arg Leu Ser Gly Glu Asp Cys 
        435                 440                 445             


Val Val Gly Gly Phe His Val Pro Ala Gly Thr Arg Leu Trp Ala Asn 
    450                 455                 460                 


Val Trp Lys Met Gln Arg Asp Pro Lys Val Trp Asp Asp Pro Leu Val 
465                 470                 475                 480 


Phe Arg Pro Asp Arg Phe Leu Ser Asp Glu Gln Lys Met Val Asp Val 
                485                 490                 495     


Arg Gly Gln Asn Tyr Glu Leu Leu Pro Phe Gly Ala Gly Arg Arg Val 
            500                 505                 510         


Cys Pro Gly Val Ser Phe Ser Leu Asp Leu Met Gln Leu Val Leu Thr 
        515                 520                 525             


Arg Leu Ile Leu Glu Phe Glu Met Lys Ser Pro Ser Gly Lys Val Asp 
    530                 535                 540                 


Met Thr Ala Thr Pro Gly Leu Met Ser Tyr Lys Val Ile Pro Leu Asp 
545                 550                 555                 560 


Ile Leu Leu Thr His Arg Arg Ile Lys Pro Cys Val Gln Ser Ala Ala 
                565                 570                 575     


Ser Glu Arg Asp 
            580 


<210>  3
<211>  321
<212>  PRT
<213>  Papaver somniferum

<400>  3

Met Glu Ser Ser Gly Val Pro Val Ile Thr Leu Gly Ser Gly Lys Val 
1               5                   10                  15      


Met Pro Val Leu Gly Met Gly Thr Phe Glu Lys Val Gly Lys Gly Ser 
            20                  25                  30          


Glu Arg Glu Arg Leu Ala Ile Leu Lys Ala Ile Glu Val Gly Tyr Arg 
        35                  40                  45              


Tyr Phe Asp Thr Ala Ala Ala Tyr Glu Thr Glu Glu Val Leu Gly Glu 
    50                  55                  60                  


Ala Ile Ala Glu Ala Leu Gln Leu Gly Leu Val Lys Ser Arg Asp Glu 
65                  70                  75                  80  


Leu Phe Ile Ser Ser Met Leu Trp Cys Thr Asp Ala His Ala Asp Arg 
                85                  90                  95      


Val Leu Leu Ala Leu Gln Asn Ser Leu Arg Asn Leu Lys Leu Glu Tyr 
            100                 105                 110         


Val Asp Leu Tyr Met Leu Pro Phe Pro Ala Ser Leu Lys Pro Gly Lys 
        115                 120                 125             


Ile Thr Met Asp Ile Pro Glu Glu Asp Ile Cys Arg Met Asp Tyr Arg 
    130                 135                 140                 


Ser Val Trp Ala Ala Met Glu Glu Cys Gln Asn Leu Gly Phe Thr Lys 
145                 150                 155                 160 


Ser Ile Gly Val Ser Asn Phe Ser Cys Lys Lys Leu Gln Glu Leu Met 
                165                 170                 175     


Ala Thr Ala Asn Ile Pro Pro Ala Val Asn Gln Val Glu Met Ser Pro 
            180                 185                 190         


Ala Phe Gln Gln Lys Lys Leu Arg Glu Tyr Cys Asn Ala Asn Asn Ile 
        195                 200                 205             


Leu Val Ser Ala Ile Ser Val Leu Gly Ser Asn Gly Thr Pro Trp Gly 
    210                 215                 220                 


Ser Asn Ala Val Leu Gly Ser Glu Val Leu Lys Lys Ile Ala Met Ala 
225                 230                 235                 240 


Lys Gly Lys Ser Val Ala Gln Val Ser Met Arg Trp Val Tyr Glu Gln 
                245                 250                 255     


Gly Ala Ser Leu Val Val Lys Ser Phe Ser Glu Glu Arg Leu Arg Glu 
            260                 265                 270         


Asn Leu Asn Ile Phe Asp Trp Glu Leu Thr Lys Glu Asp His Glu Lys 
        275                 280                 285             


Ile Gly Glu Ile Pro Gln Cys Arg Ile Leu Ser Ala Tyr Phe Leu Val 
    290                 295                 300                 


Ser Pro Asn Gly Pro Phe Lys Ser Gln Glu Glu Leu Trp Asp Asp Glu 
305                 310                 315                 320 


Ala 
    


<210>  4
<211>  2830
<212>  DNA
<213>  Papaver somniferum

<400>  4
atggagctcc aatatatttc ttattttcaa ccaacttcct ccgttgttgc tcttctactt       60

gctcttgtat ccatcttatc cagtgtcgtt gttttgagga agacattttt gaataactac      120

tcatcatcac ctgcatcatc cacaaaaaca gcggtacttt ctcatcagcg gcagcagtcg      180

tgtgcattgc caatttccgg tctcctccat attttcatga ataaaaacgg cttaattcat      240

gtaactcttg gaaatatggc tgataaatac ggtccgattt tcagtttccc aacaggtagc      300

catagaactc tcgttgtgag cagttgggag atggtaaaag agtgttttac tggcaacaat      360

gacactgctt tctcaaaccg tcctatcccg ttagctttta agactatatt ctatgcatgc      420

ggtggcatag actcatacgg tctttcgagt gtaccttatg gaaaatattg gagggagctt      480

cgaaaggtct gtgtgcataa cctcctgtct aatcaacaac tactcaagtt cagacacttg      540

ataatttctc aagtcgatac gtctttcaat aagctgtatg agttatgcaa aaactctgaa      600

gacaaccatg gaaactatac tactactact actaccgcag ctggcatggt gagaatcgat      660

gattggctcg ccgaattatc gttcaatgtg ataggaagaa tagtctgcgg attccaatca      720

ggccctaaga caggtgctcc aagcagggtg gaacaattta aagaagcaat taatgaagca      780

tcttatttta tgtcgacatc tccagtgtca gataatgttc caatgctagg gtggattgac      840

caattgacag gtcttacgag aaatatgaag cactgcggaa agaaattaga cttggtggtc      900

gagagcataa ttaatgatca tcgtcaaaag agacgattct ctagaactaa aggaggagat      960

gagaaggacg atgaacaaga tgacttcatc gacatttgtt tgtcaataat ggagcaacca     1020

cagcttcctg gcaacaataa tccttctcag atacctatca aatctattgt cctggacatg     1080

ataggtgggg gcactgacac cacaaaactg accaccatct ggaccctttc cttgctgctg     1140

aacaaccccc atgtgttgga caaggcaaaa caagaagtgg atgcacactt tcgaaccaaa     1200

aggagatcaa caaatgatgc agcagcagcc gtggtggatt ttgatgatat tcgtaacctt     1260

gtctacatcc aggcaatcat caaagaatca atgcggttgt atccagccag ccccgtggtg     1320

gagcgactga gcggcgaaga ttgtgtggtc ggtgggtttc atgtaccagc agggacgaga     1380

ttatgggcta acgtatggaa gatgcaacga gaccctaaag tatgggatga tccattggtg     1440

tttcgaccag acagattttt gagcgatgaa cagaagatgg ttgatgtaag gggtcaaaat     1500

tatgagctgt taccatttgg agccggtcga cgtgtatgtc caggtgtatc cttctctttg     1560

gatctaatgc aactggtact gactcgtctt attctcgagt ttgaaatgaa gtctcctagc     1620

gggaaagtgg acatgacagc aacaccagga ttaatgagtt acaaggtgat cccccttgac     1680

attctgctca cccatcgtcg cataaagccg tgtgtgcagt cagcagcctc tgagagagac     1740

atggagagta gtggtgtacc agtaatcact ctgggctcgg gcaaggtgat gcctgttctt     1800

ggcatgggaa catttgagaa agttggtaaa gggtccgaaa gagagaggtt ggcgatttta     1860

aaagcgatag aggtgggtta cagatacttc gatacagctg ctgcatacga aactgaagag     1920

gttcttggag aagctattgc tgaagcactt caacttggcc tagtcaaatc tcgagatgaa     1980

cttttcatca gttccatgct ctggtgcact gatgctcacg ctgatcgtgt cctcctcgct     2040

cttcagaatt cgctgaggaa tcttaaattg gagtatgtgg atctatatat gttacccttc     2100

ccggcaagct tgaagcctgg gaagataacg atggacatac cagaggaaga tatttgtcgc     2160

atggactaca ggtctgtatg ggcagccatg gaagagtgtc aaaaccttgg cttcactaaa     2220

tcaatcggtg ttagcaattt ctcctgcaaa aagcttcagg aattgatggc gactgccaac     2280

atccctccag ctgtgaatca agtggagatg agcccggctt tccaacaaaa gaagctgaga     2340

gagtattgca acgcaaataa tatattagtc agtgcaatct ctgtactggg atcaaacgga     2400

accccatggg gctccaatgc agttttgggt tctgaggtgc ttaagaaaat tgctatggcc     2460

aaaggaaaat ctgttgctca ggttagtatg agatgggttt acgagcaagg cgcgagtctt     2520

gtggtaaaaa gtttcagtga agagagattg agggaaaact tgaacatatt tgactgggaa     2580

ctcactaagg aagaccatga aaagatcggt gagattccac agtgcagaat cttgagtgct     2640

tattttttgg tctcacctaa tggacctttc aaatctcaag aagagttgtg ggatgatgaa     2700

gcttgaaaca tcgatcactt aactctagac atgcatttat aagagaagct tcccctgctg     2760

tgtgctcaat cttgatttat tttatcaaat tacatcttgc tataagggag tcacggatct     2820

cattcccttc                                                            2830


<210>  5
<211>  1740
<212>  DNA
<213>  Papaver somniferum

<400>  5
atggagctcc aatatatttc ttattttcaa ccaacttcct ccgttgttgc tcttctactt       60

gctcttgtat ccatcttatc cagtgtcgtt gttttgagga agacattttt gaataactac      120

tcatcatcac ctgcatcatc cacaaaaaca gcggtacttt ctcatcagcg gcagcagtcg      180

tgtgcattgc caatttccgg tctcctccat attttcatga ataaaaacgg cttaattcat      240

gtaactcttg gaaatatggc tgataaatac ggtccgattt tcagtttccc aacaggtagc      300

catagaactc tcgttgtgag cagttgggag atggtaaaag agtgttttac tggcaacaat      360

gacactgctt tctcaaaccg tcctatcccg ttagctttta agactatatt ctatgcatgc      420

ggtggcatag actcatacgg tctttcgagt gtaccttatg gaaaatattg gagggagctt      480

cgaaaggtct gtgtgcataa cctcctgtct aatcaacaac tactcaagtt cagacacttg      540

ataatttctc aagtcgatac gtctttcaat aagctgtatg agttatgcaa aaactctgaa      600

gacaaccatg gaaactatac tactactact actaccgcag ctggcatggt gagaatcgat      660

gattggctcg ccgaattatc gttcaatgtg ataggaagaa tagtctgcgg attccaatca      720

ggccctaaga caggtgctcc aagcagggtg gaacaattta aagaagcaat taatgaagca      780

tcttatttta tgtcgacatc tccagtgtca gataatgttc caatgctagg gtggattgac      840

caattgacag gtcttacgag aaatatgaag cactgcggaa agaaattaga cttggtggtc      900

gagagcataa ttaatgatca tcgtcaaaag agacgattct ctagaactaa aggaggagat      960

gagaaggacg atgaacaaga tgacttcatc gacatttgtt tgtcaataat ggagcaacca     1020

cagcttcctg gcaacaataa tccttctcag atacctatca aatctattgt cctggacatg     1080

ataggtgggg gcactgacac cacaaaactg accaccatct ggaccctttc cttgctgctg     1140

aacaaccccc atgtgttgga caaggcaaaa caagaagtgg atgcacactt tcgaaccaaa     1200

aggagatcaa caaatgatgc agcagcagcc gtggtggatt ttgatgatat tcgtaacctt     1260

gtctacatcc aggcaatcat caaagaatca atgcggttgt atccagccag ccccgtggtg     1320

gagcgactga gcggcgaaga ttgtgtggtc ggtgggtttc atgtaccagc agggacgaga     1380

ttatgggcta acgtatggaa gatgcaacga gaccctaaag tatgggatga tccattggtg     1440

tttcgaccag acagattttt gagcgatgaa cagaagatgg ttgatgtaag gggtcaaaat     1500

tatgagctgt taccatttgg agccggtcga cgtgtatgtc caggtgtatc cttctctttg     1560

gatctaatgc aactggtact gactcgtctt attctcgagt ttgaaatgaa gtctcctagc     1620

gggaaagtgg acatgacagc aacaccagga ttaatgagtt acaaggtgat cccccttgac     1680

attctgctca cccatcgtcg cataaagccg tgtgtgcagt cagcagcctc tgagagagac     1740


<210>  6
<211>  1090
<212>  DNA
<213>  Papaver somniferum

<400>  6
atggagagta gtggtgtacc agtaatcact ctgggctcgg gcaaggtgat gcctgttctt       60

ggcatgggaa catttgagaa agttggtaaa gggtccgaaa gagagaggtt ggcgatttta      120

aaagcgatag aggtgggtta cagatacttc gatacagctg ctgcatacga aactgaagag      180

gttcttggag aagctattgc tgaagcactt caacttggcc tagtcaaatc tcgagatgaa      240

cttttcatca gttccatgct ctggtgcact gatgctcacg ctgatcgtgt cctcctcgct      300

cttcagaatt cgctgaggaa tcttaaattg gagtatgtgg atctatatat gttacccttc      360

ccggcaagct tgaagcctgg gaagataacg atggacatac cagaggaaga tatttgtcgc      420

atggactaca ggtctgtatg ggcagccatg gaagagtgtc aaaaccttgg cttcactaaa      480

tcaatcggtg ttagcaattt ctcctgcaaa aagcttcagg aattgatggc gactgccaac      540

atccctccag ctgtgaatca agtggagatg agcccggctt tccaacaaaa gaagctgaga      600

gagtattgca acgcaaataa tatattagtc agtgcaatct ctgtactggg atcaaacgga      660

accccatggg gctccaatgc agttttgggt tctgaggtgc ttaagaaaat tgctatggcc      720

aaaggaaaat ctgttgctca ggttagtatg agatgggttt acgagcaagg cgcgagtctt      780

gtggtaaaaa gtttcagtga agagagattg agggaaaact tgaacatatt tgactgggaa      840

ctcactaagg aagaccatga aaagatcggt gagattccac agtgcagaat cttgagtgct      900

tattttttgg tctcacctaa tggacctttc aaatctcaag aagagttgtg ggatgatgaa      960

gcttgaaaca tcgatcactt aactctagac atgcatttat aagagaagct tcccctgctg     1020

tgtgctcaat cttgatttat tttatcaaat tacatcttgc tataagggag tcacggatct     1080

cattcccttc                                                            1090


<210>  7
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker linking SEQ ID2 and 3

<400>  7

Lys Pro Cys Val Gln Ser Ala Ala Ser Glu Arg Asp 
1               5                   10          


<210>  8
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  Linker linking SEQ ID 5 and 6

<400>  8
aagccgtgtg tgcagtcagc agcctctgag agagac                                 36


<210>  9
<211>  1483
<212>  DNA
<213>  Papaver somniferum

<400>  9
gccgtgtgtg cagtcagcag cctctgagag agacatggag agtagtggtg taccagtaat       60

tactctgagc tcgggcaagt tgatgcctgt tctgggcatg ggaacatttg agaaagttgg      120

taaagggtcc gaaagagaga ggttggtgat tttaaaagcg atagaggtgg gttacagata      180

cttcgataca gctgctgcat acgaaactga agaggttctt ggagaagcta ttgctgaagc      240

actccaactt ggcctaatca aatctcgaga tgaacttttc atcagttcca tgctctggtg      300

cactgatgct catcctgatc gtgtcctcct cgctcttcag aattctctga ggtaaacttt      360

tttgatgcaa attaggctta tatatatatg tgcaaagcct ttgcacatac cagtaggtac      420

acttaaaaca tctatcatat tttagataaa tgaaattgtt ttgtgtgata tagccatata      480

ggaatcttaa attggagtat ctggatctat atatgttacc cttcccggta agcttgaagc      540

cagggaagat aacgatggac atacaagagg aagatatttg tcgcatggac tacaggtctg      600

tatgggcagc catggaagag tgtcagaacc ttggcttcac taaatcaatc ggtgttagta      660

atttctcctg caaaaagctt caggaattga tggcgaccgc caacatccct ccagatgtga      720

atcaagtgag tactcttact tgaaagtttt gataaaacat cggaagattt ctaatgctta      780

ttaaatttcc aacattatgc ataatactac tactctttat aatgttgatt aaggtggaga      840

tgagcccggc tttccaacaa aagaagctga gagattattg caacgcaaat aatatactag      900

tcagtgcagt ctctatactg ggatcaaacg gaaccccatg gggctccaat gcagttttgg      960

gttctgaggt gcttaggaaa attgctatgg ccaaaggaaa atctgttgct caggttggtc     1020

aaattctctg catatgccat agtgtggtct ctgttctttg gcatcgtatt tgcatcacat     1080

tgtattcctt ccttacacgg aatgtaactt acatttgtat tgcgtactga tcaggttagt     1140

atgagatggg tttacgatca aggcgcgagt cttgtggtaa aaagtttcag tgaagagaga     1200

ttgagggaaa acttgaacat atttgactgg gaactcacta aggaagacca tgaaaagatc     1260

ggtgagattc cacagtgcag aatcttgagt gcttattttt tggtctcacc taatggacct     1320

ttcaaatctc aagaagagtt gtgggatgac gaagcttgaa acatcgatca tttaactcta     1380

gacatgcatt tataaaagaa gcttcccctg ctgtgtgctc aatcttgatt tattttatca     1440

aattacatct ggctataagg aagtcacgga tctcattccc ttc                       1483


<210>  10
<211>  966
<212>  DNA
<213>  Papaver somniferum

<400>  10
atggagagta gtggtgtacc agtaattact ctgagctcgg gcaagttgat gcctgttctg       60

ggcatgggaa catttgagaa agttggtaaa gggtccgaaa gagagaggtt ggtgatttta      120

aaagcgatag aggtgggtta cagatacttc gatacagctg ctgcatacga aactgaagag      180

gttcttggag aagctattgc tgaagcactc caacttggcc taatcaaatc tcgagatgaa      240

cttttcatca gttccatgct ctggtgcact gatgctcatc ctgatcgtgt cctcctcgct      300

cttcagaatt ctctgaggaa tcttaaattg gagtatctgg atctatatat gttacccttc      360

ccggtaagct tgaagccagg gaagataacg atggacatac aagaggaaga tatttgtcgc      420

atggactaca ggtctgtatg ggcagccatg gaagagtgtc agaaccttgg cttcactaaa      480

tcaatcggtg ttagtaattt ctcctgcaaa aagcttcagg aattgatggc gaccgccaac      540

atccctccag atgtgaatca agtggagatg agcccggctt tccaacaaaa gaagctgaga      600

gattattgca acgcaaataa tatactagtc agtgcagtct ctatactggg atcaaacgga      660

accccatggg gctccaatgc agttttgggt tctgaggtgc ttaggaaaat tgctatggcc      720

aaaggaaaat ctgttgctca ggttagtatg agatgggttt acgatcaagg cgcgagtctt      780

gtggtaaaaa gtttcagtga agagagattg agggaaaact tgaacatatt tgactgggaa      840

ctcactaagg aagaccatga aaagatcggt gagattccac agtgcagaat cttgagtgct      900

tattttttgg tctcacctaa tggacctttc aaatctcaag aagagttgtg ggatgacgaa      960

gcttga                                                                 966


<210>  11
<211>  321
<212>  PRT
<213>  Papaver somniferum

<400>  11

Met Glu Ser Ser Gly Val Pro Val Ile Thr Leu Ser Ser Gly Lys Leu 
1               5                   10                  15      


Met Pro Val Leu Gly Met Gly Thr Phe Glu Lys Val Gly Lys Gly Ser 
            20                  25                  30          


Glu Arg Glu Arg Leu Val Ile Leu Lys Ala Ile Glu Val Gly Tyr Arg 
        35                  40                  45              


Tyr Phe Asp Thr Ala Ala Ala Tyr Glu Thr Glu Glu Val Leu Gly Glu 
    50                  55                  60                  


Ala Ile Ala Glu Ala Leu Gln Leu Gly Leu Ile Lys Ser Arg Asp Glu 
65                  70                  75                  80  


Leu Phe Ile Ser Ser Met Leu Trp Cys Thr Asp Ala His Pro Asp Arg 
                85                  90                  95      


Val Leu Leu Ala Leu Gln Asn Ser Leu Arg Asn Leu Lys Leu Glu Tyr 
            100                 105                 110         


Leu Asp Leu Tyr Met Leu Pro Phe Pro Val Ser Leu Lys Pro Gly Lys 
        115                 120                 125             


Ile Thr Met Asp Ile Gln Glu Glu Asp Ile Cys Arg Met Asp Tyr Arg 
    130                 135                 140                 


Ser Val Trp Ala Ala Met Glu Glu Cys Gln Asn Leu Gly Phe Thr Lys 
145                 150                 155                 160 


Ser Ile Gly Val Ser Asn Phe Ser Cys Lys Lys Leu Gln Glu Leu Met 
                165                 170                 175     


Ala Thr Ala Asn Ile Pro Pro Asp Val Asn Gln Val Glu Met Ser Pro 
            180                 185                 190         


Ala Phe Gln Gln Lys Lys Leu Arg Asp Tyr Cys Asn Ala Asn Asn Ile 
        195                 200                 205             


Leu Val Ser Ala Val Ser Ile Leu Gly Ser Asn Gly Thr Pro Trp Gly 
    210                 215                 220                 


Ser Asn Ala Val Leu Gly Ser Glu Val Leu Arg Lys Ile Ala Met Ala 
225                 230                 235                 240 


Lys Gly Lys Ser Val Ala Gln Val Ser Met Arg Trp Val Tyr Asp Gln 
                245                 250                 255     


Gly Ala Ser Leu Val Val Lys Ser Phe Ser Glu Glu Arg Leu Arg Glu 
            260                 265                 270         


Asn Leu Asn Ile Phe Asp Trp Glu Leu Thr Lys Glu Asp His Glu Lys 
        275                 280                 285             


Ile Gly Glu Ile Pro Gln Cys Arg Ile Leu Ser Ala Tyr Phe Leu Val 
    290                 295                 300                 


Ser Pro Asn Gly Pro Phe Lys Ser Gln Glu Glu Leu Trp Asp Asp Glu 
305                 310                 315                 320 


Ala 
    


<210>  12
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(39)
<223>  R = A or G, V = A, C or G; N = A/T or C/G

<400>  12
attctagatc cracatgttt tttttttttt tttttttvn                              39


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  13
gggttgaatc atggagctc                                                    19


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
gaagggaatg agatccgtga c                                                 21


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  15
gccgtgtgtg cagtcagcag                                                   20


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  16
gaagggaatg agatccgtga c                                                 21


<210>  17
<211>  101
<212>  DNA
<213>  Papaver somniferum


<220>
<221>  misc_feature
<222>  (1)..(101)
<223>  n is either G or A

<400>  17
tggcctagtc aaatctcgag atgaactttt catcagttcc atgctctgnt gcactgatgc       60

tcacgctgat cgtgtcctcc tcgctcttca gaattcgctg a                          101


<210>  18
<211>  201
<212>  DNA
<213>  Papaver somniferum


<220>
<221>  misc_feature
<222>  (1)..(201)
<223>  n is either G or A

<400>  18
tgctccaagc agggtggaac aatttaaaga agcaattaat gaagcatctt attttatgtc       60

gacatctcca gtgtcagata atgttccaat gctagggtgn attgaccaat tgacaggtct      120

tacgagaaat atgaagcact gcggaaagaa attagacttg gtggtcgaga gcataattaa      180

tgatcatcgt caaaagagac g                                                201


<210>  19
<211>  217
<212>  DNA
<213>  Papaver somniferum


<220>
<221>  misc_feature
<222>  (1)..(217)
<223>  n is either G or A

<400>  19
gtgtatcctt ctctttggat ctaatgcaac tggtactgac tcgtcttatt ctcgagtttg       60

aaatgaagtc tcctagcggg aaagtggaca tgacagcaac accangatta atgagttaca      120

aggtgatccc ccttgacatt ctgctcaccc atcgtcgcat aaagccgtgt gtgcagtcag      180

cagcctctga gagagacatg gagagtagtg gtgtacc                               217


<210>  20
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  20
atcagcgtga gcatcagtgc ac                                                22


<210>  21
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  21
gatcagcgtg agcatcagtg cat                                               23


<210>  22
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  22
tctcgagatg aacttttcat cagttccat                                         29


<210>  23
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  23
cgtaagacct gtcaattggt caatc                                             25


<210>  24
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  24
cgtaagacct gtcaattggt caatt                                             25


<210>  25
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  25
tccagtgtca gataatgttc caatgcta                                          28


<210>  26
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  26
gtggacatga cagcaacacc ag                                                22


<210>  27
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  27
aaagtggaca tgacagcaac accaa                                             25


<210>  28
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  28
caagggggat caccttgtaa ctcat                                             25


<210>  29
<211>  2706
<212>  DNA
<213>  papaver somniferum

<400>  29
atggagctcc aatatatttc ttattttcaa ccaacttcct ccgttgttgc tcttctactt       60

gctcttgtat ccatcttatc cagtgtcgtt gttttgagga agacattttt gaataactac      120

tcatcatcac ctgcatcatc cacaaaaaca gcggtacttt ctcatcagcg gcagcagtcg      180

tgtgcattgc caatttccgg tctcctccat attttcatga ataaaaacgg cttaattcat      240

gtaactcttg gaaatatggc tgataaatac ggtccgattt tcagtttccc aacaggtagc      300

catagaactc tcgttgtgag cagttgggag atggtaaaag agtgttttac tggcaacaat      360

gacactgctt tctcaaaccg tcctatcccg ttagctttta agactatatt ctatgcatgc      420

ggtggcatag actcatacgg tctttcgagt gtaccttatg gaaaatattg gagggagctt      480

cgaaaggtct gtgtgcataa cctcctgtct aatcaacaac tactcaagtt cagacacttg      540

ataatttctc aagtcgatac gtctttcaat aagctgtatg agttatgcaa aaactctgaa      600

gacaaccatg gaaactatac tactactact actaccgcag ctggcatggt gagaatcgat      660

gattggctcg ccgaattatc gttcaatgtg ataggaagaa tagtctgcgg attccaatca      720

ggccctaaga caggtgctcc aagcagggtg gaacaattta aagaagcaat taatgaagca      780

tcttatttta tgtcgacatc tccagtgtca gataatgttc caatgctagg gtggattgac      840

caattgacag gtcttacgag aaatatgaag cactgcggaa agaaattaga cttggtggtc      900

gagagcataa ttaatgatca tcgtcaaaag agacgattct ctagaactaa aggaggagat      960

gagaaggacg atgaacaaga tgacttcatc gacatttgtt tgtcaataat ggagcaacca     1020

cagcttcctg gcaacaataa tccttctcag atacctatca aatctattgt cctggacatg     1080

ataggtgggg gcactgacac cacaaaactg accaccatct ggaccctttc cttgctgctg     1140

aacaaccccc atgtgttgga caaggcaaaa caagaagtgg atgcacactt tcgaaccaaa     1200

aggagatcaa caaatgatgc agcagcagcc gtggtggatt ttgatgatat tcgtaacctt     1260

gtctacatcc aggcaatcat caaagaatca atgcggttgt atccagccag ccccgtggtg     1320

gagcgactga gcggcgaaga ttgtgtggtc ggtgggtttc atgtaccagc agggacgaga     1380

ttatgggcta acgtatggaa gatgcaacga gaccctaaag tatgggatga tccattggtg     1440

tttcgaccag acagattttt gagcgatgaa cagaagatgg ttgatgtaag gggtcaaaat     1500

tatgagctgt taccatttgg agccggtcga cgtgtatgtc caggtgtatc cttctctttg     1560

gatctaatgc aactggtact gactcgtctt attctcgagt ttgaaatgaa gtctcctagc     1620

gggaaagtgg acatgacagc aacaccagga ttaatgagtt acaaggtgat cccccttgac     1680

attctgctca cccatcgtcg cataaagccg tgtgtgcagt cagcagcctc tgagagagac     1740

atggagagta gtggtgtacc agtaatcact ctgggctcgg gcaaggtgat gcctgttctt     1800

ggcatgggaa catttgagaa agttggtaaa gggtccgaaa gagagaggtt ggcgatttta     1860

aaagcgatag aggtgggtta cagatacttc gatacagctg ctgcatacga aactgaagag     1920

gttcttggag aagctattgc tgaagcactt caacttggcc tagtcaaatc tcgagatgaa     1980

cttttcatca gttccatgct ctggtgcact gatgctcacg ctgatcgtgt cctcctcgct     2040

cttcagaatt cgctgaggaa tcttaaattg gagtatgtgg atctatatat gttacccttc     2100

ccggcaagct tgaagcctgg gaagataacg atggacatac cagaggaaga tatttgtcgc     2160

atggactaca ggtctgtatg ggcagccatg gaagagtgtc aaaaccttgg cttcactaaa     2220

tcaatcggtg ttagcaattt ctcctgcaaa aagcttcagg aattgatggc gactgccaac     2280

atccctccag ctgtgaatca agtggagatg agcccggctt tccaacaaaa gaagctgaga     2340

gagtattgca acgcaaataa tatattagtc agtgcaatct ctgtactggg atcaaacgga     2400

accccatggg gctccaatgc agttttgggt tctgaggtgc ttaagaaaat tgctatggcc     2460

aaaggaaaat ctgttgctca ggttagtatg agatgggttt acgagcaagg cgcgagtctt     2520

gtggtaaaaa gtttcagtga agagagattg agggaaaact tgaacatatt tgactgggaa     2580

ctcactaagg aagaccatga aaagatcggt gagattccac agtgcagaat cttgagtgct     2640

tattttttgg tctcacctaa tggacctttc aaatctcaag aagagttgtg ggatgatgaa     2700

gcttga                                                                2706


<210>  30
<211>  2052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yeast codon optimised PsCPR

<400>  30
atgggttcaa acaacttagc caactcaata gaatcaatgt taggtatctc aataggttca       60

gaatacatct ccgatccaat ctttatcatg gtcactacag ttgcttccat gttaattggt      120

tttggtttct ttgcatgtat gaaatcttca tccagtcaat ctaagccaat cgaaacttac      180

aagcctatca tcgacaagga agaagaagaa atcgaagttg atccaggtaa aattaaattg      240

acaatctttt tcggtacaca aaccggtact gcagaaggtt ttgccaaagc tttggcagaa      300

gaaattaaag caaagtacaa aaaggccgtt gtaaaggtcg ttgatttgga tgactatgct      360

gcagaagatg accaatacga agaaaagttg aaaaaggaat ctttggtttt ctttatggta      420

gctacatatg gtgacggtga acctaccgat aatgccgcta gattttacaa gtggttcaca      480

caagaacatg aacgtggtga atggttgcaa caattaacct atggtgtttt tggtttgggt      540

aacagacaat acgaacactt caacaaaatt gcagtcgacg ttgatgaaca attgggtaaa      600

caaggtgcta agagaatagt acaagtcggt ttaggtgacg acgatcaatg tatcgaagac      660

gattttactg cttggagaga attgttgtgg acagaattgg atcaattgtt gaaggacgaa      720

gatgcagccc catctgttgc taccccttat attgcaactg taccagaata cagagtagtc      780

atacatgaaa ccactgttgc tgcattggac gataaacaca ttaatactgc caacggtgac      840

gttgctttcg atatcttgca tccatgtaga acaatcgtag ctcaacaaag agaattgcat      900

aagcctaaga gtgatagatc ttgcatccac ttggaattcg atatctctgg ttcttcattg      960

acatacgaaa ccggtgacca tgttggtgta tacgccgaaa actgtgatga aaccgttgaa     1020

gaagctggta aattgttggg tcaaccattg gatttgttat tttcaataca cacagacaag     1080

gaagatggtt cccctcaagg ttccagtttg ccacctccat tccctggtcc atgcactttg     1140

agatctgcct tagctagata tgcagatttg ttaaatcctc caagaaaagc ttcattgata     1200

gcattatccg cacatgcctc agttccatcc gaagctgaaa gattgagatt tttatcttca     1260

cctttgggta aaaacgaata ctctaagtgg gttgtaggta gtcaaagatc tttgttagaa     1320

atcatggcag aattcccatc agccaaacct ccattgggtg ttttctttgc cgctgtagct     1380

cctagattac ctccaagata ttactccatc tccagttctc caaagtttgc acctagtaga     1440

attcatgtca catgtgcctt ggtttatggt caatctccaa ccggtagagt ccatagaggt     1500

gtttgctcaa cttggatgaa acacgccgtc ccacaagata gttgggctcc tatattcgtt     1560

agaacttcta acttcaagtt gcctgctgat ccatcaaccc ctatcattat ggttggtcca     1620

ggtactggtt tagcaccttt tagaggtttc ttgcaagaaa gaatggcctt aaaagaaaac     1680

ggtgctcaat tgggtccagc agttttattt ttcggttgta gaaacagaaa catggacttc     1740

atctatgaag atgaattgaa caacttcgta gaaagaggtg tcattagtga attagttata     1800

gcattttcta gagaaggtga aaagaaagaa tacgttcaac ataagatgat ggaaaaggct     1860

acagacgtat ggaatgtcat ctctggtgac ggttatttgt acgtatgcgg tgacgccaag     1920

ggtatggcta gagatgtcca tagaacttta cacacaattg ctcaagaaca aggtccaatg     1980

gaatcatccg cagccgaagc tgcagttaag aaattgcaag tcgaagaaag atatttgaga     2040

gatgtttggt aa                                                         2052


<210>  31
<211>  2706
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yeast Codon optimized STORR (CYP82Y2)

<400>  31
atggaattac aatacatctc ctactttcaa ccaacctctt cagtcgtcgc tttgttatta       60

gcattagtct ctatcttatc ctccgtagtt gtattgagaa agacattttt gaacaactac      120

tcttcatccc cagccagttc tacaaagacc gctgttttgt cacatcaaag acaacaatcc      180

tgtgctttgc ctatcagtgg tttgttgcat atattcatga acaaaaacgg tttgatccac      240

gttacattgg gtaatatggc tgataagtac ggtccaatct ttagtttccc tacaggttct      300

cacagaacct tggtcgtttc atcctgggaa atggttaagg aatgcttcac tggtaacaac      360

gatacagctt tctcaaatag accaatacct ttagccttta agactatctt ctatgcttgt      420

ggtggtattg attcctacgg tttgagttct gttccatacg gtaaatactg gagagaattg      480

agaaaggtct gcgttcataa cttgttgtct aaccaacaat tgttgaagtt tagacacttg      540

attatatcac aagttgacac atccttcaac aaattgtacg aattgtgtaa gaactctgaa      600

gataaccatg gtaactacac tacaaccact acaaccgctg ctggtatggt tagaattgat      660

gactggttgg ctgaattgtc ttttaatgtt atcggtagaa tcgtatgcgg tttccaatca      720

ggtccaaaaa ctggtgcacc ttccagagtt gaacaattca aagaagcaat taacgaagcc      780

agttatttca tgtcaacatc cccagtctct gacaatgttc ctatgttagg ttggattgat      840

caattgaccg gtttgactag aaacatgaag cattgtggta aaaagttgga cttggtagtc      900

gaatcaatca ttaatgatca cagacaaaag agaagatttt ccagaactaa aggtggtgac      960

gaaaaggatg acgaacaaga tgacttcatc gatatctgct tgtcaatcat ggaacaacca     1020

caattacctg gtaacaacaa cccatctcaa atccctatta aatcaatcgt tttggacatg     1080

attggtggtg gtactgatac tacaaagttg accactatat ggacattgtc tttgttgttg     1140

aacaacccac atgtcttaga caaagcaaag caagaagttg atgcccactt tagaaccaaa     1200

agaagatcta ctaacgacgc cgctgcagcc gttgtagatt tcgatgacat cagaaatttg     1260

gtttacatcc aagccataat caaggaatcc atgagattgt acccagctag tcctgtcgtt     1320

gaaagattat ctggtgaaga ttgtgtagtc ggtggttttc atgtaccagc tggtactaga     1380

ttatgggcaa acgtctggaa aatgcaaaga gatcctaagg tttgggatga cccattggtt     1440

tttagacctg atagattctt atcagacgaa caaaagatgg tagatgtcag aggtcaaaac     1500

tacgaattgt tgccattcgg tgctggtaga agagtatgtc ctggtgtcag tttctctttg     1560

gatttgatgc aattagtttt gaccagattg atattggaat tcgaaatgaa gtcaccatcc     1620

ggtaaagttg atatgactgc tacaccaggt ttgatgtctt acaaagtaat ccctttggat     1680

atcttgttga cacatagaag aattaaacca tgcgttcaat cagctgcatc cgaaagagat     1740

atggaatcat ccggtgttcc agtaatcacc ttgggttctg gtaaagtcat gcctgttttg     1800

ggtatgggta cttttgaaaa agttggtaaa ggttccgaaa gagaaagatt ggctatatta     1860

aaggcaatcg aagtaggtta tagatacttc gatacagccg ctgcatatga aaccgaagaa     1920

gtcttgggtg aagcaattgc cgaagctttg caattgggtt tagttaaatc tagagatgaa     1980

ttgtttataa gttctatgtt gtggtgtact gatgcacacg ccgacagagt attgttggct     2040

ttgcaaaaca gtttgagaaa tttgaagttg gaatatgtcg atttgtacat gttaccattt     2100

cctgcatctt tgaagccagg taaaatcaca atggatatcc ctgaagaaga catctgtaga     2160

atggattaca gaagtgtttg ggccgctatg gaagaatgcc aaaacttagg ttttacaaag     2220

tctatcggtg ttagtaactt ctcttgtaaa aagttgcaag aattaatggc taccgcaaac     2280

attccacctg ctgtaaatca agtcgaaatg tcaccagcat tccaacaaaa gaaattgaga     2340

gaatactgca atgcaaacaa tatattggtc tcagccatct ccgttttagg ttctaacggt     2400

actccttggg gttccaatgc tgtattgggt agtgaagtct tgaagaaaat tgccatggct     2460

aaaggtaaaa gtgttgcaca agtatctatg agatgggttt atgaacaagg tgcctctttg     2520

gttgtaaaga gtttttctga agaaagattg agagaaaact taaacatctt cgactgggaa     2580

ttgacaaagg aagatcatga aaagattggt gaaataccac aatgtagaat attgtctgct     2640

tactttttag tttcaccaaa tggtcctttc aaatctcaag aagaattatg ggatgacgaa     2700

gcataa                                                                2706


<210>  32
<211>  1743
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yeast codon optimized CYP82Y2

<400>  32
atggaattac aatacatttc ttactttcaa cctacatcct ctgtcgtcgc cttgttatta       60

gcattagtct ctatcttatc ctccgtcgtt gtattgagaa agacattttt gaacaactac      120

tcttcatccc cagcaagttc tacaaagacc gccgttttat cacatcaaag acaacaatcc      180

tgtgctttgc ctataagtgg tttgttgcat atctttatga acaaaaacgg tttgatccac      240

gtaacattgg gtaatatggc tgataagtac ggtccaattt tctctttccc tacaggttcc      300

cacagaacct tagtcgtttc atcctgggaa atggttaagg aatgcttcac tggtaacaac      360

gatacagctt tcagtaatag accaatccct ttggctttta aaactatttt ctatgcctgt      420

ggtggtatag attcttacgg tttaagttct gttccatatg gtaaatactg gagagaattg      480

agaaaggttt gcgtacataa cttgttatca aatcaacaat tgttgaagtt tagacactta      540

ataatcagtc aagttgatac atctttcaac aaattatatg aattgtgtaa gaattctgaa      600

gacaaccatg gtaattacac tacaaccact acaaccgctg ctggtatggt tagaattgat      660

gactggttag ccgaattgtc ttttaatgtc ataggtagaa tcgtttgcgg tttccaatca      720

ggtccaaaaa ctggtgcacc ttccagagtt gaacaattca aagaagccat aaacgaagct      780

agttatttca tgtcaacatc cccagtatct gataatgtcc ctatgttggg ttggattgac      840

caattaaccg gtttgactag aaacatgaag cattgtggta aaaagttgga tttggtagtc      900

gaatcaatca ttaatgacca cagacaaaag agaagatttt ccagaactaa aggtggtgac      960

gaaaaggatg acgaacaaga tgacttcatc gacatctgct tgtctatcat ggaacaacca     1020

caattgcctg gtaacaacaa cccatctcaa atccctatta aatcaatcgt tttggatatg     1080

attggtggtg gtacagacac tacaaagtta accactattt ggaccttgtc attgttgttg     1140

aacaacccac atgttttgga taaggctaag caagaagtag acgcacactt tagaaccaaa     1200

agaagatcca ctaacgatgc cgctgcagcc gttgtagact tcgatgacat aagaaatttg     1260

gtttacatcc aagctataat caaagaatcc atgagattgt acccagcaag tcctgtcgtt     1320

gaaagattgt ctggtgaaga ttgtgtagtc ggtggttttc atgtcccagc cggtactaga     1380

ttgtgggcta acgtttggaa aatgcaaaga gatcctaaag tatgggatga cccattagtc     1440

tttagacctg atagattctt gtctgacgaa caaaagatgg tcgatgttag aggtcaaaac     1500

tacgaattgt tgccatttgg tgctggtaga agagtttgtc ctggtgtaag tttctctttg     1560

gatttgatgc aattagtttt gaccagattg atattggaat tcgaaatgaa gtcaccatcc     1620

ggtaaagtag atatgactgc tacaccaggt ttaatgtctt acaaagtcat tcctttggat     1680

atcttgttga cacatagaag aattaagcca tgcgttcaaa gtgctgcatc tgaaagagat     1740

taa                                                                   1743


<210>  33
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yeast codon optimised Oxidoreductase

<400>  33
atggaatcct ctggtgtccc tgttatcaca ttgggttctg gtaaagttat gcctgtcttg       60

ggtatgggta catttgaaaa ggtcggtaaa ggttctgaaa gagaaagatt agccatcttg      120

aaggctattg aagttggtta tagatacttt gacactgctg cagcctatga aacagaagaa      180

gtattaggtg aagccatcgc tgaagcattg caattaggtt tggtcaagtc tagagatgaa      240

ttattcattt cttcaatgtt gtggtgtaca gatgcccatg ctgacagagt tttgttagct      300

ttgcaaaact ctttgagaaa cttaaagttg gaatacgtag atttgtacat gttgccattt      360

cctgcttcat tgaagccagg taaaatcacc atggatatcc ctgaagaaga catatgtaga      420

atggattaca gatccgtttg ggctgcaatg gaagaatgcc aaaatttggg ttttaccaag      480

agtatcggtg tttctaactt ctcatgtaaa aagttgcaag aattgatggc aactgccaat      540

atcccacctg ctgtcaacca agttgaaatg tccccagcat tccaacaaaa gaaattgaga      600

gaatactgca acgcaaacaa cattttagtt tccgccataa gtgtattggg ttcaaatggt      660

actccttggg gttccaacgc tgtcttaggt agtgaagttt tgaaaaagat tgctatggca      720

aagggtaaat ctgtagccca agtctcaatg agatgggttt atgaacaagg tgcatcatta      780

gttgtaaaat cctttagtga agaaagattg agagaaaatt tgaacatatt cgactgggaa      840

ttgacaaaag aagatcacga aaagattggt gaaataccac aatgcagaat cttgtctgct      900

tactttttgg tttcaccaaa tggtcctttc aagtctcaag aagaattgtg ggatgacgaa      960

gcataa                                                                 966


<210>  34
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer XhoIF

<400>  34
aaaaggatcc aaaaatgggt tcaaacaact tagccaactc                             40


<210>  35
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer CPR BamH1

<400>  35
aaaactcgag ttaccaaaca tctctcaaat atctttcttc                             40


<210>  36
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer CYP82X

<400>  36
aaaagcggcc gcaaaaatgg aattacaata catctcctac tttc                        44


<210>  37
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer CYP82X

<400>  37
aaaattaatt aattatgctt cgtcatccca taattc                                 36


<210>  38
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer CYO82X NotI F

<400>  38
aaaagcggcc gcaaaaatgg aattacaata catttcttac tttc                        44


<210>  39
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer CYP82X PacI R

<400>  39
aaaattaatt aatctctttc agatgcagca c                                      31


<210>  40
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer oxired NotI F

<400>  40
aaaagcggcc gcaaaaatgg aatcctctgg tgtccctg                               38


<210>  41
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer oxired R

<400>  41
aaaattaatt aattatgctt cgtcatccca caattc                                 36


<210>  42
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  42
tccagggacc agcaatggag ctccaatata tttcttattt tcaac                       45


<210>  43
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  43
tgaggagaag gcgcgttaag cttcatcatc ccacaactct tc                          42


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STORR Peptide

<400>  44

Thr Ala Val Leu Ser His Gln Arg 
1               5               


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STORR Peptide

<400>  45

Tyr Gly Pro Ile Phe Ser Phe Pro Thr Gly Ser His Arg 
1               5                   10              


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STORR Peptide

<400>  46

Ile Val Cys Gly Phe Gln Ser Gly Pro Lys 
1               5                   10  


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STORR Peptide

<400>  47

Leu Tyr Pro Ala Ser Pro Val Val Glu Arg 
1               5                   10  


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STORR Peptide

<400>  48

Ile Lys Pro Cys Val Gln Ser Ala Ala Ser Glu Arg 
1               5                   10          


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STORR Peptide

<400>  49

Ile Gly Glu Ile Pro Gln Cys Arg 
1               5               


<210>  50
<211>  966
<212>  DNA
<213>  Papaver somniferum

<400>  50
atggagagta gtggtgtacc agtaatcact ctgggctcgg gcaaggtgat gcctgttctt       60

ggcatgggaa catttgagaa agttggtaaa gggtccgaaa gagagaggtt ggcgatttta      120

aaagcgatag aggtgggtta cagatacttc gatacagctg ctgcatacga aactgaagag      180

gttcttggag aagctattgc tgaagcactt caacttggcc tagtcaaatc tcgagatgaa      240

cttttcatca gttccatgct ctggtgcact gatgctcacg ctgatcgtgt cctcctcgct      300

cttcagaatt cgctgaggaa tcttaaattg gagtatgtgg atctatatat gttacccttc      360

ccggcaagct tgaagcctgg gaagataacg atggacatac cagaggaaga tatttgtcgc      420

atggactaca ggtctgtatg ggcagccatg gaagagtgtc aaaaccttgg cttcactaaa      480

tcaatcggtg ttagcaattt ctcctgcaaa aagcttcagg aattgatggc gactgccaac      540

atccctccag ctgtgaatca agtggagatg agcccggctt tccaacaaaa gaagctgaga      600

gagtattgca acgcaaataa tatattagtc agtgcaatct ctgtactggg atcaaacgga      660

accccatggg gctccaatgc agttttgggt tctgaggtgc ttaagaaaat tgctatggcc      720

aaaggaaaat ctgttgctca ggttagtatg agatgggttt acgagcaagg cgcgagtctt      780

gtggtaaaaa gtttcagtga agagagattg agggaaaact tgaacatatt tgactgggaa      840

ctcactaagg aagaccatga aaagatcggt gagattccac agtgcagaat cttgagtgct      900

tattttttgg tctcacctaa tggacctttc aaatctcaag aagagttgtg ggatgatgaa      960

gcttga                                                                 966


<210>  51
<211>  2650
<212>  DNA
<213>  Papaver somniferum

<400>  51
cggcacgagc ttgttagtat cttctagggt ttgaaaagaa gcacagggag aagcaaaagt       60

cgaatctact tgaaatacat tcgattgctt ctctctgttt aagcttcaga gtctctgcta      120

attatgggtt cgaataattt agctaattcg attgaatcga tgttaggaat atcaatagga      180

tcagaatata tttctgaccc aattttcatt atggtcacaa ctgtagcttc aatgctgatt      240

ggatttggtt tcttcgcatg tatgaaatct tcgtcttctc aatcaaaacc tattgaaact      300

tataaaccaa taattgataa agaagaagag gagattgaag ttgatcctgg taaaattaag      360

ctcactatat tttttggtac tcagactggt actgctgaag gatttgctaa ggcattggca      420

gaagaaatta aggcaaagta caagaaagca gttgttaaag tagttgacct ggatgactat      480

gcagccgagg atgatcaata tgaagagaaa ttaaagaaag agtctttggt gtttttcatg      540

gtagccactt atggtgatgg tgagccaact gacaatgctg cgagatttta caaatggttc      600

actcaggaac atgaaagggg agagtggctt cagcaactaa cttatggtgt ttttggtttg      660

ggtaaccgtc aatacgagca tttcaacaag atcgcggtag atgtggatga gcaactcggt      720

aaacaaggtg caaagcgcat tgttcaagtg gggctcggtg acgatgatca atgcattgaa      780

gatgatttta ctgcttggcg agaattgttg tggactgaat tggatcagtt gctcaaagat      840

gaggatgctg ctccttcagt ggctacaccg tatattgcta ctgttcctga atacagggta      900

gtgattcacg aaactacggt cgcggctctg gatgataaac acataaatac tgctaacggc      960

gatgttgcat ttgatattct ccatccttgc agaaccattg ttgctcaaca aagagagctc     1020

cacaaaccca agtctgatag atcctgtata catctggagt tcgacatatc aggctcttcc     1080

cttacatatg agactggaga tcatgttggt gtttatgctg agaactgcga tgaaactgtc     1140

gaggaagcag ggaagctgtt gggtcaaccc ctggatttgc tgttttcaat tcacacggat     1200

aaagaagacg ggtcacccca gggaagctca ttaccacctc ctttcccagg tccttgcacc     1260

ttacgatctg ccctagcacg ctatgctgat cttttgaatc ctcctagaaa ggcttctctg     1320

attgctctgt ccgctcatgc atctgtaccc agtgaagcag agagattgcg ctttttgtca     1380

tcacctctgg gaaagaatga gtattcaaaa tgggtagttg gaagtcagag gagtcttttg     1440

gagatcatgg ccgagtttcc atcagcaaaa ccccctcttg gtgttttctt tgctgcagta     1500

gcccctcgct taccgcctcg atactattct atctcatcct ctcctaagtt tgctccctca     1560

agaattcatg tgacgtgtgc tttagtatat ggtcaaagcc ctaccggaag ggttcaccga     1620

ggagtgtgtt cgacatggat gaagcatgca gttcctcagg atagctgggc tcctattttt     1680

gttcgaacgt caaacttcaa gttaccagct gacccctcaa ctccaattat catggtggga     1740

cctggtacag ggttagctcc tttcagagga tttctgcagg aaagaatggc cctcaaggaa     1800

aatggtgctc aacttggccc agcagtgctc tttttcggat gtaggaatcg taatatggac     1860

ttcatttatg aagacgaact aaacaacttc gtggaacgag gagtaatttc ggagctagtt     1920

attgcctttt cacgtgaagg ggaaaagaag gaatatgttc aacataagat gatggagaaa     1980

gcaacggatg tatggaatgt gatatcaggg gacggttatc tctatgtgtg tggtgatgcc     2040

aagggaatgg ccagagatgt ccatcgcacg ttgcatacca ttgcccaaga acagggaccc     2100

atggaatcat ctgctgccga agctgcagta aagaaactcc aagttgaaga acgatatcta     2160

agagatgtct ggtgatcgaa tgtagcttgc caagtcccct tttcttggct ggtctgttta     2220

tggtttctat tatattattg atcctcctct gaaaatccca agcacttcca gacatccctc     2280

gattcttcct ccagtggttc caaatcgaag ctcggtataa ttgagagcag tgcaattgtg     2340

actacatgag aagcaaacat cgaataccat agaattagaa agatcaaaat tctcttatca     2400

gaacaatgtt acaggcaaaa ctgtgtttgc ttaatataaa tttcacacca tgggtgtgga     2460

caacactgaa acagtattag ctataccaac aaagttatgc aaggaaacac aaactagtta     2520

gatcttctct ttggattgat tactgtaagt tctaaccaga tgatagattg tacttaaaga     2580

ttcttgtttt cttatggcta ccgagaggag tatattaatg catttagagt tttgagaaaa     2640

aaaaaaaaaa                                                            2650




