                         SEQUENCE LISTING

<110>  Tan, Patrick Boon Ooi
       Tan, Puay Hoon
 
<120>  Breast Fibroadenoma Susceptibility Mutations And Use Thereof

<130>  TEA-P001WO

<150>  SG10201402277X
<151>  2014-05-12

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  1
tgttctacac ggaaccctcc tc                                                22


<210>  2
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2
ctgggcaaat gccaatgaga t                                                 21


<210>  3
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  3
ttctcctgcc ctactctccc ac                                                22


<210>  4
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  4
caggctggtt attgaaacct tg                                                22


<210>  5
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  5
ccctaaggaa aaaacaacta aacgc                                             25


<210>  6
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  6
ctgccatgct catccccaga                                                   20


<210>  7
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  7
cttgttcctt cttttctcct gcc                                               23


<210>  8
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  8
gttttacatt caaggccgtc ag                                                22


<210>  9
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  9
caactaaacg ccgctttcct g                                                 21


<210>  10
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  10
aagctgacgt tcttggcact gc                                                22


<210>  11
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  11
gctttcctgc ctcaggatga act                                               23


<210>  12
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  12
ccttggcagg attgaagctg ac                                                22


<210>  13
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  13
gatgaactga cggccttgaa tgta                                              24


<210>  14
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  14
cctggcagag ttgtctcacc ttg                                               23


<210>  15
<211>  6985
<212>  DNA
<213>  Homo sapiens

<400>  15
attgtccgat ggttcccggc gtacctcggc ttccctcggt agtttccggc aatggtcgag       60

agtttctaac gtgccccctt gttgtctctc ggccgccgtc ctctcaacca ccgcccccct      120

tttcggctcc ctctccccct tcccgttccc ccagtcagcc tggccctgct ggtgcctccg      180

gcgctacggg ctgggcaaga tggcggcctt cgggatcttg agctacgaac accggcccct      240

gaagcggccg cggctggggc ctcccgatgt ttaccctcag gaccccaaac agaaggagga      300

tgaactgacg gccttgaatg taaaacaagg tttcaataac cagcctgctg tctctgggga      360

tgagcatggc agtgccaaga acgtcagctt caatcctgcc aagatcagtt ccaacttcag      420

cagcattatt gcagagaaat tacgttgtaa tacccttcct gacactggtc gcaggaagcc      480

ccaagtgaac cagaaggata acttctggct ggtgactgca cgatcccaga gtgccattaa      540

cacttggttc actgacttgg ctggcaccaa gccactcacg caactagcca aaaaggtccc      600

cattttcagt aagaaggaag aggtgtttgg gtacttagcc aaatacacag tgcctgtgat      660

gcgggctgcc tggctcatta agatgacctg tgcctactat gcagcaatct ctgagaccaa      720

ggttaagaag agacatgttg accctttcat ggaatggact cagatcatca ccaagtactt      780

atgggagcag ttacagaaga tggctgaata ctaccggcca gggcctgcag gaagtggggg      840

ctgtggttcc acgatagggc ccttgcccca tgatgtagag gtggcaatcc ggcagtggga      900

ttacaccgag aagctggcca tgttcatgtt tcaggatgga atgctggaca gacatgagtt      960

cctgacctgg gtgcttgagt gttttgagaa gatccgccct ggagaggatg aattgcttaa     1020

actgctgctg cctctgcttc tccgatactc tggggaattt gttcagtctg catacctgtc     1080

ccgccggctt gcctacttct gtacacggag actggccctg cagctggatg gtgtgagcag     1140

tcactcatct catgttatat ctgctcagtc aacaagcacg ctacccacca cccctgctcc     1200

tcagccccca actagcagca caccctcgac tccctttagt gacctgctta tgtgccctca     1260

gcaccggccc ctggtttttg gcctcagctg tatcctacag accatcctcc tgtgctgtcc     1320

tagtgccttg gtttggcact actcactgac tgatagcaga attaagaccg gctcaccact     1380

tgaccacttg cctattgccc cgtccaacct gcccatgcca gagggtaaca gtgccttcac     1440

tcagcaggtc cgtgcaaagt tgcgggagat cgagcagcag atcaaggagc ggggacaggc     1500

agttgaagtt cgctggtctt tcgataaatg ccaggaagct actgcaggct tcaccattgg     1560

acgggtactt catactttgg aagtgctgga cagccatagt tttgaacgct ctgacttcag     1620

caactctctt gactcccttt gtaaccgaat ctttggattg ggacctagca aggatgggca     1680

tgagatctcc tcagatgatg atgctgtggt gtcattgcta tgtgaatggg ctgtcagctg     1740

caagcgttct ggtcggcatc gtgctatggt ggtagccaag ctcctggaga agagacaggc     1800

ggagattgag gctgagcgtt gtggagaatc agaagccgca gatgagaagg gttccatcgc     1860

ctctggctcc ctttctgctc ccagtgctcc cattttccag gatgtcctcc tgcagtttct     1920

ggatacacag gctcccatgc tgacggaccc tcgaagtgag agtgagcggg tggaattctt     1980

taacttagta ctgctgttct gtgaactgat tcgacatgat gttttctccc acaacatgta     2040

tacttgcact ctcatctccc gaggggacct tgcctttgga gcccctggtc cccggcctcc     2100

ctctcccttt gatgatcctg ccgatgaccc agagcacaag gaggctgaag gcagcagcag     2160

cagcaagctg gaagatccag ggctctcaga atctatggac attgacccta gttccagtgt     2220

tctctttgag gacatggaga agcctgattt ctcattgttc tcccctacta tgccctgtga     2280

ggggaagggc agtccatccc ctgagaagcc agatgtcgag aaggaggtga agcccccacc     2340

caaggagaag attgaaggga cccttggggt tctttacgac cagccacgac acgtgcagta     2400

cgccacccat tttcccatcc cccaggagga gtcatgcagc catgagtgca accagcggtt     2460

ggtcgtactg tttggggtgg gaaagcagcg agatgatgcc cgccatgcca tcaagaaaat     2520

caccaaggat atcttgaagg ttctgaaccg caaagggaca gcagaaactg accagcttgc     2580

tcctattgtg cctctgaatc ctggagacct gacattctta ggtggggagg atgggcagaa     2640

gcggcgacgc aaccggcctg aagccttccc cactgctgaa gatatctttg ctaagttcca     2700

gcacctttca cattatgacc aacaccaggt cacggctcag gtctcccgga atgttctgga     2760

gcagatcacg agctttgccc ttggcatgtc ataccacttg cctctggtgc agcatgtgca     2820

gttcatcttc gacctcatgg aatattcact cagcatcagt ggcctcatcg actttgccat     2880

tcagctgctg aatgaactga gtgtagttga ggctgagctg cttctcaaat cctcggatct     2940

ggtgggcagc tacactacta gcctgtgcct gtgcatcgtg gctgtcctgc ggcactatca     3000

tgcctgcctc atcctcaacc aggaccagat ggcacaggtc tttgaggggc tgtgtggcgt     3060

cgtgaagcat gggatgaacc ggtccgatgg ctcctctgca gagcgctgta tccttgctta     3120

tctctatgat ctgtacacct cctgtagcca tttaaagaac aaatttgggg agctcttcag     3180

cgacttttgc tcaaaggtga agaacaccat ctactgcaac gtggagccat cggaatcaaa     3240

tatgcgctgg gcacctgagt tcatgatcga cactctagag aaccctgcag ctcacacctt     3300

cacctacacg gggctaggca agagtcttag tgagaaccct gctaaccgct acagctttgt     3360

ctgcaatgcc cttatgcacg tctgtgtggg gcaccatgat cccgataggg tgaatgacat     3420

cgcaatcctg tgtgcagagc tgaccggcta ttgcaagtca ctgagtgcag aatggctagg     3480

agtgcttaag gccttgtgct gctcctctaa caatggcact tgtggtttca acgatctcct     3540

ctgcaatgtt gatgtcagtg acctatcttt tcatgactcg ctggctactt ttgttgccat     3600

cctcatcgct cggcagtgtt tgctcctgga agatctgatt cgctgtgctg ccatcccttc     3660

actccttaat gctgcttgta gtgaacagga ctctgagcca ggggcccggc ttacctgccg     3720

catcctcctt caccttttca agacaccgca gctcaatcct tgccagtctg atggaaacaa     3780

gcctacagta ggaatccgct cctcctgcga ccgccacctg ctggctgcct cccagaaccg     3840

catcgtggat ggagccgtgt ttgctgttct caaggctgtg tttgtacttg gggatgcgga     3900

actgaaaggt tcaggcttca ctgtgacagg aggaacagaa gaacttccag aggaggaggg     3960

aggaggtggc agtggtggtc ggaggcaggg tggccgcaac atctctgtgg agacagccag     4020

tctggatgtc tatgccaagt acgtgctgcg cagcatctgc caacaggaat gggtaggaga     4080

acgttgcctt aagtctctgt gtgaggacag caatgacctg caagacccag tgttgagtag     4140

tgcccaggcg cagcgcctca tgcagctcat ttgctatcca catcgactgc tggacaatga     4200

ggatggggaa aacccccagc ggcagcgcat aaagcgcatt ctccagaact tggaccagtg     4260

gaccatgcgc cagtcttcct tggagctgca gctcatgatc aagcagaccc ctaacaatga     4320

gatgaactcc ctcttggaga acatcgccaa ggccacaatc gaggttttcc aacagtcagc     4380

agagacaggg tcatcttctg gaagtactgc aagcaacatg cccagcagca gcaagaccaa     4440

gcctgtgctc agctctctag agcgctctgg tgtatggctg gtggcccccc tcattgctaa     4500

actgcccacc tcagtccagg gacatgtgtt aaaggctgct ggggaagaat tggagaaggg     4560

tcagcacctg ggttcctctt cacgcaaaga acgtgatcga caaaagcaga agagcatgtc     4620

cctattgagc cagcagccct tcttatcgct ggtgctaaca tgtctgaaag ggcaggatga     4680

acaacgcgag ggactcctta cctccctcta cagccaggtg caccagattg tgaataattg     4740

gcgagatgac cagtacttag atgattgcaa accaaagcag cttatgcatg aggcactcaa     4800

actgcggctc aacctggtgg ggggcatgtt tgacacggtg cagcgcagca cccagcagac     4860

cacggagtgg gccatgctcc tcctggagat catcatcagc ggcactgtcg acatgcagtc     4920

caacaatgag ctcttcacta ctgtgttgga catgctgagc gtgctcatca atgggacatt     4980

ggctgcagac atgtctagca tctcgcaagg tagcatggag gaaaacaagc gtgcatacat     5040

gaacctggcg aagaagttgc agaaggagtt gggggagcgc cagtcagaca gtctggaaaa     5100

ggttcgccag ctgctgccac tgcccaagca gacccgagat gtcatcacgt gtgagccaca     5160

gggctccctt atcgatacca agggcaacaa gattgctggc ttcgattcca tcttcaagaa     5220

ggagggtcta caggtttcca ccaaacagaa gatctcgccc tgggatcttt ttgaggggtt     5280

gaagccgtca gcaccactct cttggggctg gtttggaaca gtccgagtgg accggcgagt     5340

ggctcgagga gaggagcagc agcggttgct gctctaccac acacacctga ggccccggcc     5400

ccgcgcctat tacctggagc cactgccact gcccccagaa gatgaggagc cgcctgctcc     5460

taccctgcta gagcctgaga aaaaggctcc agagcccccc aaaactgaca aaccgggggc     5520

tgctccaccc agtactgagg aacgcaagaa gaagtccacc aagggcaaga aacgcagcca     5580

gccagctacc aagacagagg actatggaat gggcccgggt cggagcggcc cttatggtgt     5640

gacagtgcct ccggacctcc tgcaccaccc aaaccctggt tctataacac accttaacta     5700

caggcaaggc tccataggcc tgtacaccca gaaccagcca ctacctgcag gtggccctcg     5760

tgtggaccca taccgtcctg tgcgcttacc aatgcagaag ctgcccaccc gaccaactta     5820

ccctggagtg ctgcccacaa ccatgactgg cgtcatgggt ttagaaccct cctcttataa     5880

gacctctgtg taccggcagc agcaacctgc ggtgccccaa ggacagcgcc ttcgccaaca     5940

gctccagcag agtcagggca tgttgggaca gtcatctgtc catcagatga ctcccagctc     6000

ttcctacggt ttgcagactt cccagggcta tactccttat gtttctcatg tgggattgca     6060

gcaacacaca ggccctgcag gtaccatggt gccccccagc tactccagcc agccttacca     6120

gagcacccac ccttctacca atcctactct tgtagatcct acccgccacc tgcaacagcg     6180

gcccagtggc tatgtgcacc agcaggcccc cacctatgga catggactga cctccactca     6240

aaggttttca caccagacac tgcagcagac acccatgata agtaccatga ctccaatgag     6300

tgcccagggc gtccaggcag gcgtccgttc aacagccatc ctacctgagc agcagcagca     6360

gcagcaacag cagcaacagc aacagcagca gcagcagcaa cagcaacagc agcagcagca     6420

gcagcagtac cacatccggc agcagcagca gcagcagatc ctgcggcagc agcagcaaca     6480

gcaacagcag cagcagcagc agcagcaaca gcaacagcag cagcagcaac agcaacaaca     6540

gcaacaccag cagcaacagc agcaacaggc ggctcctccc caaccccagc cccagtccca     6600

gccccagttc cagcgccagg ggcttcagca gacccagcag cagcaacaga cagcagcttt     6660

ggtccggcaa cttcaacaac agctctctaa tacccagcca cagcccagta ccaacatatt     6720

tggacgctac tgagccacct ggaggaactg cttgtgcact ggatgtggcc ccaccctttc     6780

ctcttaattc ccaatcccat tcctgggcta gcaccagtag tggttggggc cctcccctca     6840

ggctccattt ttaataagtt tttagtattt ttgttaatgt gaggcattga gctgttgggt     6900

tttgtatatt atttatatag agaccccaga gctgttgcac ccaatacaca gagcttcttt     6960

gcaaagggaa aaaaaaaaaa aaaaa                                           6985


<210>  16
<211>  2177
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ala Phe Gly Ile Leu Ser Tyr Glu His Arg Pro Leu Lys Arg 
1               5                   10                  15      


Pro Arg Leu Gly Pro Pro Asp Val Tyr Pro Gln Asp Pro Lys Gln Lys 
            20                  25                  30          


Glu Asp Glu Leu Thr Ala Leu Asn Val Lys Gln Gly Phe Asn Asn Gln 
        35                  40                  45              


Pro Ala Val Ser Gly Asp Glu His Gly Ser Ala Lys Asn Val Ser Phe 
    50                  55                  60                  


Asn Pro Ala Lys Ile Ser Ser Asn Phe Ser Ser Ile Ile Ala Glu Lys 
65                  70                  75                  80  


Leu Arg Cys Asn Thr Leu Pro Asp Thr Gly Arg Arg Lys Pro Gln Val 
                85                  90                  95      


Asn Gln Lys Asp Asn Phe Trp Leu Val Thr Ala Arg Ser Gln Ser Ala 
            100                 105                 110         


Ile Asn Thr Trp Phe Thr Asp Leu Ala Gly Thr Lys Pro Leu Thr Gln 
        115                 120                 125             


Leu Ala Lys Lys Val Pro Ile Phe Ser Lys Lys Glu Glu Val Phe Gly 
    130                 135                 140                 


Tyr Leu Ala Lys Tyr Thr Val Pro Val Met Arg Ala Ala Trp Leu Ile 
145                 150                 155                 160 


Lys Met Thr Cys Ala Tyr Tyr Ala Ala Ile Ser Glu Thr Lys Val Lys 
                165                 170                 175     


Lys Arg His Val Asp Pro Phe Met Glu Trp Thr Gln Ile Ile Thr Lys 
            180                 185                 190         


Tyr Leu Trp Glu Gln Leu Gln Lys Met Ala Glu Tyr Tyr Arg Pro Gly 
        195                 200                 205             


Pro Ala Gly Ser Gly Gly Cys Gly Ser Thr Ile Gly Pro Leu Pro His 
    210                 215                 220                 


Asp Val Glu Val Ala Ile Arg Gln Trp Asp Tyr Thr Glu Lys Leu Ala 
225                 230                 235                 240 


Met Phe Met Phe Gln Asp Gly Met Leu Asp Arg His Glu Phe Leu Thr 
                245                 250                 255     


Trp Val Leu Glu Cys Phe Glu Lys Ile Arg Pro Gly Glu Asp Glu Leu 
            260                 265                 270         


Leu Lys Leu Leu Leu Pro Leu Leu Leu Arg Tyr Ser Gly Glu Phe Val 
        275                 280                 285             


Gln Ser Ala Tyr Leu Ser Arg Arg Leu Ala Tyr Phe Cys Thr Arg Arg 
    290                 295                 300                 


Leu Ala Leu Gln Leu Asp Gly Val Ser Ser His Ser Ser His Val Ile 
305                 310                 315                 320 


Ser Ala Gln Ser Thr Ser Thr Leu Pro Thr Thr Pro Ala Pro Gln Pro 
                325                 330                 335     


Pro Thr Ser Ser Thr Pro Ser Thr Pro Phe Ser Asp Leu Leu Met Cys 
            340                 345                 350         


Pro Gln His Arg Pro Leu Val Phe Gly Leu Ser Cys Ile Leu Gln Thr 
        355                 360                 365             


Ile Leu Leu Cys Cys Pro Ser Ala Leu Val Trp His Tyr Ser Leu Thr 
    370                 375                 380                 


Asp Ser Arg Ile Lys Thr Gly Ser Pro Leu Asp His Leu Pro Ile Ala 
385                 390                 395                 400 


Pro Ser Asn Leu Pro Met Pro Glu Gly Asn Ser Ala Phe Thr Gln Gln 
                405                 410                 415     


Val Arg Ala Lys Leu Arg Glu Ile Glu Gln Gln Ile Lys Glu Arg Gly 
            420                 425                 430         


Gln Ala Val Glu Val Arg Trp Ser Phe Asp Lys Cys Gln Glu Ala Thr 
        435                 440                 445             


Ala Gly Phe Thr Ile Gly Arg Val Leu His Thr Leu Glu Val Leu Asp 
    450                 455                 460                 


Ser His Ser Phe Glu Arg Ser Asp Phe Ser Asn Ser Leu Asp Ser Leu 
465                 470                 475                 480 


Cys Asn Arg Ile Phe Gly Leu Gly Pro Ser Lys Asp Gly His Glu Ile 
                485                 490                 495     


Ser Ser Asp Asp Asp Ala Val Val Ser Leu Leu Cys Glu Trp Ala Val 
            500                 505                 510         


Ser Cys Lys Arg Ser Gly Arg His Arg Ala Met Val Val Ala Lys Leu 
        515                 520                 525             


Leu Glu Lys Arg Gln Ala Glu Ile Glu Ala Glu Arg Cys Gly Glu Ser 
    530                 535                 540                 


Glu Ala Ala Asp Glu Lys Gly Ser Ile Ala Ser Gly Ser Leu Ser Ala 
545                 550                 555                 560 


Pro Ser Ala Pro Ile Phe Gln Asp Val Leu Leu Gln Phe Leu Asp Thr 
                565                 570                 575     


Gln Ala Pro Met Leu Thr Asp Pro Arg Ser Glu Ser Glu Arg Val Glu 
            580                 585                 590         


Phe Phe Asn Leu Val Leu Leu Phe Cys Glu Leu Ile Arg His Asp Val 
        595                 600                 605             


Phe Ser His Asn Met Tyr Thr Cys Thr Leu Ile Ser Arg Gly Asp Leu 
    610                 615                 620                 


Ala Phe Gly Ala Pro Gly Pro Arg Pro Pro Ser Pro Phe Asp Asp Pro 
625                 630                 635                 640 


Ala Asp Asp Pro Glu His Lys Glu Ala Glu Gly Ser Ser Ser Ser Lys 
                645                 650                 655     


Leu Glu Asp Pro Gly Leu Ser Glu Ser Met Asp Ile Asp Pro Ser Ser 
            660                 665                 670         


Ser Val Leu Phe Glu Asp Met Glu Lys Pro Asp Phe Ser Leu Phe Ser 
        675                 680                 685             


Pro Thr Met Pro Cys Glu Gly Lys Gly Ser Pro Ser Pro Glu Lys Pro 
    690                 695                 700                 


Asp Val Glu Lys Glu Val Lys Pro Pro Pro Lys Glu Lys Ile Glu Gly 
705                 710                 715                 720 


Thr Leu Gly Val Leu Tyr Asp Gln Pro Arg His Val Gln Tyr Ala Thr 
                725                 730                 735     


His Phe Pro Ile Pro Gln Glu Glu Ser Cys Ser His Glu Cys Asn Gln 
            740                 745                 750         


Arg Leu Val Val Leu Phe Gly Val Gly Lys Gln Arg Asp Asp Ala Arg 
        755                 760                 765             


His Ala Ile Lys Lys Ile Thr Lys Asp Ile Leu Lys Val Leu Asn Arg 
    770                 775                 780                 


Lys Gly Thr Ala Glu Thr Asp Gln Leu Ala Pro Ile Val Pro Leu Asn 
785                 790                 795                 800 


Pro Gly Asp Leu Thr Phe Leu Gly Gly Glu Asp Gly Gln Lys Arg Arg 
                805                 810                 815     


Arg Asn Arg Pro Glu Ala Phe Pro Thr Ala Glu Asp Ile Phe Ala Lys 
            820                 825                 830         


Phe Gln His Leu Ser His Tyr Asp Gln His Gln Val Thr Ala Gln Val 
        835                 840                 845             


Ser Arg Asn Val Leu Glu Gln Ile Thr Ser Phe Ala Leu Gly Met Ser 
    850                 855                 860                 


Tyr His Leu Pro Leu Val Gln His Val Gln Phe Ile Phe Asp Leu Met 
865                 870                 875                 880 


Glu Tyr Ser Leu Ser Ile Ser Gly Leu Ile Asp Phe Ala Ile Gln Leu 
                885                 890                 895     


Leu Asn Glu Leu Ser Val Val Glu Ala Glu Leu Leu Leu Lys Ser Ser 
            900                 905                 910         


Asp Leu Val Gly Ser Tyr Thr Thr Ser Leu Cys Leu Cys Ile Val Ala 
        915                 920                 925             


Val Leu Arg His Tyr His Ala Cys Leu Ile Leu Asn Gln Asp Gln Met 
    930                 935                 940                 


Ala Gln Val Phe Glu Gly Leu Cys Gly Val Val Lys His Gly Met Asn 
945                 950                 955                 960 


Arg Ser Asp Gly Ser Ser Ala Glu Arg Cys Ile Leu Ala Tyr Leu Tyr 
                965                 970                 975     


Asp Leu Tyr Thr Ser Cys Ser His Leu Lys Asn Lys Phe Gly Glu Leu 
            980                 985                 990         


Phe Ser Asp Phe Cys Ser Lys Val  Lys Asn Thr Ile Tyr  Cys Asn Val 
        995                 1000                 1005             


Glu Pro  Ser Glu Ser Asn Met  Arg Trp Ala Pro Glu  Phe Met Ile 
    1010                 1015                 1020             


Asp Thr  Leu Glu Asn Pro Ala  Ala His Thr Phe Thr  Tyr Thr Gly 
    1025                 1030                 1035             


Leu Gly  Lys Ser Leu Ser Glu  Asn Pro Ala Asn Arg  Tyr Ser Phe 
    1040                 1045                 1050             


Val Cys  Asn Ala Leu Met His  Val Cys Val Gly His  His Asp Pro 
    1055                 1060                 1065             


Asp Arg  Val Asn Asp Ile Ala  Ile Leu Cys Ala Glu  Leu Thr Gly 
    1070                 1075                 1080             


Tyr Cys  Lys Ser Leu Ser Ala  Glu Trp Leu Gly Val  Leu Lys Ala 
    1085                 1090                 1095             


Leu Cys  Cys Ser Ser Asn Asn  Gly Thr Cys Gly Phe  Asn Asp Leu 
    1100                 1105                 1110             


Leu Cys  Asn Val Asp Val Ser  Asp Leu Ser Phe His  Asp Ser Leu 
    1115                 1120                 1125             


Ala Thr  Phe Val Ala Ile Leu  Ile Ala Arg Gln Cys  Leu Leu Leu 
    1130                 1135                 1140             


Glu Asp  Leu Ile Arg Cys Ala  Ala Ile Pro Ser Leu  Leu Asn Ala 
    1145                 1150                 1155             


Ala Cys  Ser Glu Gln Asp Ser  Glu Pro Gly Ala Arg  Leu Thr Cys 
    1160                 1165                 1170             


Arg Ile  Leu Leu His Leu Phe  Lys Thr Pro Gln Leu  Asn Pro Cys 
    1175                 1180                 1185             


Gln Ser  Asp Gly Asn Lys Pro  Thr Val Gly Ile Arg  Ser Ser Cys 
    1190                 1195                 1200             


Asp Arg  His Leu Leu Ala Ala  Ser Gln Asn Arg Ile  Val Asp Gly 
    1205                 1210                 1215             


Ala Val  Phe Ala Val Leu Lys  Ala Val Phe Val Leu  Gly Asp Ala 
    1220                 1225                 1230             


Glu Leu  Lys Gly Ser Gly Phe  Thr Val Thr Gly Gly  Thr Glu Glu 
    1235                 1240                 1245             


Leu Pro  Glu Glu Glu Gly Gly  Gly Gly Ser Gly Gly  Arg Arg Gln 
    1250                 1255                 1260             


Gly Gly  Arg Asn Ile Ser Val  Glu Thr Ala Ser Leu  Asp Val Tyr 
    1265                 1270                 1275             


Ala Lys  Tyr Val Leu Arg Ser  Ile Cys Gln Gln Glu  Trp Val Gly 
    1280                 1285                 1290             


Glu Arg  Cys Leu Lys Ser Leu  Cys Glu Asp Ser Asn  Asp Leu Gln 
    1295                 1300                 1305             


Asp Pro  Val Leu Ser Ser Ala  Gln Ala Gln Arg Leu  Met Gln Leu 
    1310                 1315                 1320             


Ile Cys  Tyr Pro His Arg Leu  Leu Asp Asn Glu Asp  Gly Glu Asn 
    1325                 1330                 1335             


Pro Gln  Arg Gln Arg Ile Lys  Arg Ile Leu Gln Asn  Leu Asp Gln 
    1340                 1345                 1350             


Trp Thr  Met Arg Gln Ser Ser  Leu Glu Leu Gln Leu  Met Ile Lys 
    1355                 1360                 1365             


Gln Thr  Pro Asn Asn Glu Met  Asn Ser Leu Leu Glu  Asn Ile Ala 
    1370                 1375                 1380             


Lys Ala  Thr Ile Glu Val Phe  Gln Gln Ser Ala Glu  Thr Gly Ser 
    1385                 1390                 1395             


Ser Ser  Gly Ser Thr Ala Ser  Asn Met Pro Ser Ser  Ser Lys Thr 
    1400                 1405                 1410             


Lys Pro  Val Leu Ser Ser Leu  Glu Arg Ser Gly Val  Trp Leu Val 
    1415                 1420                 1425             


Ala Pro  Leu Ile Ala Lys Leu  Pro Thr Ser Val Gln  Gly His Val 
    1430                 1435                 1440             


Leu Lys  Ala Ala Gly Glu Glu  Leu Glu Lys Gly Gln  His Leu Gly 
    1445                 1450                 1455             


Ser Ser  Ser Arg Lys Glu Arg  Asp Arg Gln Lys Gln  Lys Ser Met 
    1460                 1465                 1470             


Ser Leu  Leu Ser Gln Gln Pro  Phe Leu Ser Leu Val  Leu Thr Cys 
    1475                 1480                 1485             


Leu Lys  Gly Gln Asp Glu Gln  Arg Glu Gly Leu Leu  Thr Ser Leu 
    1490                 1495                 1500             


Tyr Ser  Gln Val His Gln Ile  Val Asn Asn Trp Arg  Asp Asp Gln 
    1505                 1510                 1515             


Tyr Leu  Asp Asp Cys Lys Pro  Lys Gln Leu Met His  Glu Ala Leu 
    1520                 1525                 1530             


Lys Leu  Arg Leu Asn Leu Val  Gly Gly Met Phe Asp  Thr Val Gln 
    1535                 1540                 1545             


Arg Ser  Thr Gln Gln Thr Thr  Glu Trp Ala Met Leu  Leu Leu Glu 
    1550                 1555                 1560             


Ile Ile  Ile Ser Gly Thr Val  Asp Met Gln Ser Asn  Asn Glu Leu 
    1565                 1570                 1575             


Phe Thr  Thr Val Leu Asp Met  Leu Ser Val Leu Ile  Asn Gly Thr 
    1580                 1585                 1590             


Leu Ala  Ala Asp Met Ser Ser  Ile Ser Gln Gly Ser  Met Glu Glu 
    1595                 1600                 1605             


Asn Lys  Arg Ala Tyr Met Asn  Leu Ala Lys Lys Leu  Gln Lys Glu 
    1610                 1615                 1620             


Leu Gly  Glu Arg Gln Ser Asp  Ser Leu Glu Lys Val  Arg Gln Leu 
    1625                 1630                 1635             


Leu Pro  Leu Pro Lys Gln Thr  Arg Asp Val Ile Thr  Cys Glu Pro 
    1640                 1645                 1650             


Gln Gly  Ser Leu Ile Asp Thr  Lys Gly Asn Lys Ile  Ala Gly Phe 
    1655                 1660                 1665             


Asp Ser  Ile Phe Lys Lys Glu  Gly Leu Gln Val Ser  Thr Lys Gln 
    1670                 1675                 1680             


Lys Ile  Ser Pro Trp Asp Leu  Phe Glu Gly Leu Lys  Pro Ser Ala 
    1685                 1690                 1695             


Pro Leu  Ser Trp Gly Trp Phe  Gly Thr Val Arg Val  Asp Arg Arg 
    1700                 1705                 1710             


Val Ala  Arg Gly Glu Glu Gln  Gln Arg Leu Leu Leu  Tyr His Thr 
    1715                 1720                 1725             


His Leu  Arg Pro Arg Pro Arg  Ala Tyr Tyr Leu Glu  Pro Leu Pro 
    1730                 1735                 1740             


Leu Pro  Pro Glu Asp Glu Glu  Pro Pro Ala Pro Thr  Leu Leu Glu 
    1745                 1750                 1755             


Pro Glu  Lys Lys Ala Pro Glu  Pro Pro Lys Thr Asp  Lys Pro Gly 
    1760                 1765                 1770             


Ala Ala  Pro Pro Ser Thr Glu  Glu Arg Lys Lys Lys  Ser Thr Lys 
    1775                 1780                 1785             


Gly Lys  Lys Arg Ser Gln Pro  Ala Thr Lys Thr Glu  Asp Tyr Gly 
    1790                 1795                 1800             


Met Gly  Pro Gly Arg Ser Gly  Pro Tyr Gly Val Thr  Val Pro Pro 
    1805                 1810                 1815             


Asp Leu  Leu His His Pro Asn  Pro Gly Ser Ile Thr  His Leu Asn 
    1820                 1825                 1830             


Tyr Arg  Gln Gly Ser Ile Gly  Leu Tyr Thr Gln Asn  Gln Pro Leu 
    1835                 1840                 1845             


Pro Ala  Gly Gly Pro Arg Val  Asp Pro Tyr Arg Pro  Val Arg Leu 
    1850                 1855                 1860             


Pro Met  Gln Lys Leu Pro Thr  Arg Pro Thr Tyr Pro  Gly Val Leu 
    1865                 1870                 1875             


Pro Thr  Thr Met Thr Gly Val  Met Gly Leu Glu Pro  Ser Ser Tyr 
    1880                 1885                 1890             


Lys Thr  Ser Val Tyr Arg Gln  Gln Gln Pro Ala Val  Pro Gln Gly 
    1895                 1900                 1905             


Gln Arg  Leu Arg Gln Gln Leu  Gln Gln Ser Gln Gly  Met Leu Gly 
    1910                 1915                 1920             


Gln Ser  Ser Val His Gln Met  Thr Pro Ser Ser Ser  Tyr Gly Leu 
    1925                 1930                 1935             


Gln Thr  Ser Gln Gly Tyr Thr  Pro Tyr Val Ser His  Val Gly Leu 
    1940                 1945                 1950             


Gln Gln  His Thr Gly Pro Ala  Gly Thr Met Val Pro  Pro Ser Tyr 
    1955                 1960                 1965             


Ser Ser  Gln Pro Tyr Gln Ser  Thr His Pro Ser Thr  Asn Pro Thr 
    1970                 1975                 1980             


Leu Val  Asp Pro Thr Arg His  Leu Gln Gln Arg Pro  Ser Gly Tyr 
    1985                 1990                 1995             


Val His  Gln Gln Ala Pro Thr  Tyr Gly His Gly Leu  Thr Ser Thr 
    2000                 2005                 2010             


Gln Arg  Phe Ser His Gln Thr  Leu Gln Gln Thr Pro  Met Ile Ser 
    2015                 2020                 2025             


Thr Met  Thr Pro Met Ser Ala  Gln Gly Val Gln Ala  Gly Val Arg 
    2030                 2035                 2040             


Ser Thr  Ala Ile Leu Pro Glu  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2045                 2050                 2055             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2060                 2065                 2070             


Gln Gln  Gln Tyr His Ile Arg  Gln Gln Gln Gln Gln  Gln Ile Leu 
    2075                 2080                 2085             


Arg Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2090                 2095                 2100             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  His Gln Gln 
    2105                 2110                 2115             


Gln Gln  Gln Gln Gln Ala Ala  Pro Pro Gln Pro Gln  Pro Gln Ser 
    2120                 2125                 2130             


Gln Pro  Gln Phe Gln Arg Gln  Gly Leu Gln Gln Thr  Gln Gln Gln 
    2135                 2140                 2145             


Gln Gln  Thr Ala Ala Leu Val  Arg Gln Leu Gln Gln  Gln Leu Ser 
    2150                 2155                 2160             


Asn Thr  Gln Pro Gln Pro Ser  Thr Asn Ile Phe Gly  Arg Tyr 
    2165                 2170                 2175         


