                         SEQUENCE LISTING

<110>  MedImmune, LLC
 
<120>  MOLECULES WITH ALTERED NEONATE Fc RECEPTOR BINDING HAVING 
       ENHANCED THERAPEUTIC AND DIAGNOSTIC PROPERTIES

<130>  AEFC-125P1

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  2
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  3
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  4
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  5
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


<210>  6
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115    


<210>  7
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  His 435 loop region of human IgG3

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  site of known allelic variation

<400>  7

Leu His Asn Arg Phe Thr 
1               5       


<210>  8
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  His 435 loop region of human IgG1, IgG2, and IgG4

<400>  8

Leu His Asn His Tyr Thr 
1               5       


<210>  9
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can be any amino acid

<400>  9

Cys Xaa Xaa Xaa Xaa Cys 
1               5       


<210>  10
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can be any amino acid

<400>  10

Cys Xaa Xaa Xaa Xaa Cys Glu 
1               5           


<210>  11
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  modified His 435 loop region may also include a glutamate 
       insertion at position 437* as numbered by Kabat

<400>  11

Cys Xaa Arg His Xaa Cys 
1               5       


<210>  12
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  modified His 435 loop region may also include a glutamate 
       insertion at position 437* as numbered by Kabat

<400>  12

Cys Arg Arg His Xaa Cys 
1               5       


<210>  13
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  modified His 435 loop region may also include a glutamate 
       insertion at position 437* as numbered by Kabat

<400>  13

Cys Xaa Arg His Arg Cys 
1               5       


<210>  14
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is glutamate, glutamine, aspartate, or histidine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is glutamate, glutamine, aspartate, or histidine

<400>  14

Xaa Xaa Xaa His Xaa Xaa 
1               5       


<210>  15
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  His435 loop region consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is arginine or alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is tryptophan, serine, phenylalanine, or tyrosine

<400>  15

Glu Xaa Xaa His Arg Gln 
1               5       


<210>  16
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  16

Cys Ser Trp His Leu Cys Glu 
1               5           


<210>  17
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  modified His 435 loop region may also include a glutamate 
       insertion at position 437* as numbered by Kabat

<400>  17

Cys Ser Phe His Leu Cys 
1               5       


<210>  18
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  modified His 435 loop region may also include a glutamate 
       insertion at position 437* as numbered by Kabat

<400>  18

Cys Ser Ile His Leu Cys 
1               5       


<210>  19
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  modified His 435 loop region may also include a glutamate 
       insertion at position 437* as numbered by Kabat

<400>  19

Cys Ser Leu His Leu Cys 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  20

Cys Ser Trp His Leu Cys 
1               5       


<210>  21
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can be any amino acid

<400>  21

Cys Xaa Xaa His Xaa Cys 
1               5       


<210>  22
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can be any amino acid

<400>  22

Cys Xaa Xaa His Xaa Cys Glu 
1               5           


<210>  23
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X can be any amino acid

<400>  23

Xaa Xaa Xaa His Xaa Xaa 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X can be any amino acid

<400>  24

Cys Xaa Arg His Arg Xaa 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  25

Glu Arg Phe His Arg Gln 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  26

Glu Arg Tyr His Thr Gln 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  27

Glu Ala Trp His Arg Gln 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  28

His Arg Phe His Leu Gln 
1               5       


<210>  29
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  29

Glu Ala Phe His Arg Glu 
1               5       


<210>  30
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  30

Ser Ser Trp His Leu Ser 
1               5       


<210>  31
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  31

Cys His Asn His Tyr Cys 
1               5       


<210>  32
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  32

Cys Arg Arg His Leu Cys Glu 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  33

Cys Arg Arg His Ile Cys Glu 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  34

Cys Ser Arg His Arg Cys Glu 
1               5           


<210>  35
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  35

Cys Arg Arg His Ser Cys Glu 
1               5           


<210>  36
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  36

Cys Asn Arg His Arg Cys Glu 
1               5           


<210>  37
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  37

Glu Pro Tyr His Arg Glu 
1               5       


<210>  38
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  38

Glu Arg Ser His Arg Gln 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  39

Glu Pro His His Arg Gln 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  40

His Thr His His Arg Gln 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  41

Glu Pro Trp His Tyr Gln 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  42

Glu Gln Phe His Arg Gln 
1               5       


<210>  43
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  43

His His Phe His Met Gln 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  44

Gln Lys Tyr His Asn Gln 
1               5       


<210>  45
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  45

His Arg His His Arg Gln 
1               5       


<210>  46
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  46

Glu Leu Trp His Arg Gln 
1               5       


<210>  47
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  47

Glu Arg His His Arg Gln 
1               5       


<210>  48
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  48

Glu Pro Trp His Arg Glu 
1               5       


<210>  49
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  49

His Arg Phe His His Gln 
1               5       


<210>  50
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  50

Glu Ala Tyr His His Gln 
1               5       


<210>  51
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  51

Glu Gln Tyr His His Gln 
1               5       


<210>  52
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  52

Glu Pro His His Asn Gln 
1               5       


<210>  53
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  53

Glu Arg Tyr His His His 
1               5       


<210>  54
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  54

Glu Arg Tyr His Asn Gln 
1               5       


<210>  55
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  modified His435 loop region

<400>  55

Glu Thr Phe His Gly His 
1               5       


<210>  56
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (97)..(97)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (239)..(239)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (241)..(241)
<223>  site of known allelic variation

<400>  56

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  57
<211>  326
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (75)..(75)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (76)..(76)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (161)..(161)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (257)..(257)
<223>  site of known allelic variation

<400>  57

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  58
<211>  377
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (59)..(59)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (75)..(75)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (76)..(76)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (221)..(221)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (222)..(222)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (226)..(226)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (239)..(239)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (269)..(269)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (309)..(309)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (314)..(314)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (320)..(320)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (327)..(327)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (339)..(339)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (349)..(349)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (352)..(352)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (365)..(365)
<223>  site of known allelic variation

<220>
<221>  VARIANT
<222>  (366)..(366)
<223>  site of known allelic variation

<400>  58

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  59
<211>  327
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (289)..(289)
<223>  site of known allelic variation

<400>  59

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


