                         SEQUENCE LISTING

<110>  Children's Hospital Medical Center
 
<120>  METHODS FOR ASSESSING RESPONSIVENESS TO ASTHMA TREATMENT BASED ON
        VNN-1 EXPRESSION AND PROMOTER METHYLATION

<130>  C1367.70013WO00

<150>  US 61/994,477
<151>  2014-05-16

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  3844
<212>  DNA
<213>  Homo sapiens

<400>  1
agcactcatt ggacttcagc atgactactc agttgccagc ttacgtggca attttgcttt       60

tctatgtctc aagagccagc tgccaggaca ctttcactgc agctgtttat gagcatgcag      120

cgatattgcc caatgccacc ctaacaccag tgtctcgtga ggaggctttg gcattaatga      180

atcggaatct ggacattttg gaaggagcga tcacatcagc agcagatcag ggtgcgcata      240

ttattgtgac tccagaagat gctatttatg gctggaactt caacagggac tctctctacc      300

catatttgga ggacatccca gaccctgaag taaactggat cccctgtaat aatcgtaaca      360

gatttggcca gaccccagta caagaaagac tcagctgcct ggccaagaac aactctatct      420

atgttgtggc aaatattggg gacaagaagc catgcgatac cagtgatcct cagtgtcccc      480

ctgatggccg ttaccaatac aacactgatg tggtatttga ttctcaagga aaactggtgg      540

cacgctacca taagcaaaac cttttcatgg gtgaaaatca attcaatgta cccaaggagc      600

ctgagattgt gactttcaat accacctttg gaagttttgg cattttcaca tgctttgata      660

tactcttcca tgatcctgct gttaccttgg tgaaagattt ccacgtggac accatagtat      720

tcccaacagc ttggatgaat gttttgccac atttgtcagc tgttgaattc cactcagctt      780

gggctatggg catgagggtc aatttccttg catccaacat acattacccc tcaaagaaaa      840

tgacaggaag tggcatctat gcacccaatt cttcaagagc atttcattat gatatgaaga      900

cagaagaggg aaaactcctc ctctcgcaac tggattccca cccatcccat tctgcagtgg      960

tgaactggac ttcctatgcc agcagtatag aagcgctctc atcaggaaac aaggaattta     1020

aaggcactgt ctttttcgat gaattcactt ttgtgaagct cacaggagtt gcaggaaatt     1080

atacagtttg tcagaaagat ctctgctgtc atttaagcta caaaatgtct gagaacatac     1140

caaatgaagt gtacgctcta ggggcatttg acggactgca cactgtggaa gggcgctatt     1200

atctacagat ttgtaccctg ttgaaatgta aaacgactaa tttaaacact tgcggtgact     1260

cagctgaaac agcttctacc aggtttgaaa tgttctccct cagtggcact ttcggaaccc     1320

agtatgtctt tcctgaggtg ttgctgagtg aaaatcagct tgcacctgga gaatttcagg     1380

tgtcaactga cggacgcttg tttagtctga agccaacatc cggacctgtc ttaacagtaa     1440

ctctgtttgg gaggttgtat gagaaggact gggcatcaaa tgcttcatca ggcctcacag     1500

cacaagcaag aataataatg ctaatagtta tagcacctat tgtatgctca ttaagttggt     1560

agaatattga ctttttctct tttttatttg ggataattta aaaaatgatg gatgagaaaa     1620

gaaagattgg tccgggttaa tattatcctc tagtataagt gaattactag tttctcttta     1680

tttagacaaa cacacacaca ccagataata taaacttaat aaattatctg ttaatgtaga     1740

ttttatttaa aaaactatat ttgaacattg gtctttcttg gacgtgagct aattatatca     1800

aataagtatc acaaatcttt tacgcagaag aaataaaaac tacgggtaga aaacataaga     1860

actatcataa aatttactta caaggaggct gctcttgtta ccacttttat tatattacgt     1920

atcacttatt cagctctgct gaaaatttcc aatgactttg tttgtttgct ctttttgttt     1980

tttacctaaa caatacattt tgattctctt gtgggttgat aatgtctccc caaaatttac     2040

atgttgaagc acctcagaat gtgactgtat ttggagacag ggtctttaaa gaggtaaaat     2100

aaggtcatta ggatagaccc taattcaata tgactgatga tcataaaaga agaggcgagt     2160

agggcacaac aggcacaaag ggagaccata aggagacaca gaggaaggac aactctttac     2220

aagctaagaa gagagggcct cagaagaaac caaccctgcc aacaccttga tcttggactt     2280

ccagcctcca aaactatgag aaataaattt ctattgttta agtcacccag tccatggtac     2340

tttgttaggc agccctggca aatgaatcaa agacccattc ctgttcctct ccccaccact     2400

actgttttct actgtaatct gaagcttcaa caaaaggctt acctggtaag aatattcagc     2460

tggtctgggt cctcaagact ccaatagaca ctcttagaga aggattgctg atggattgat     2520

agtgaaacca ttagatcatt gaattcctct ggaattagaa aaccagagag tcccatttta     2580

agaaattaga tatttaatat agcattgtgt gttctatttt agtaacagca gaatctcttg     2640

acattacaca actcagtgaa acaacatcat ttaagccaaa atatctccca actgactgat     2700

agactctgag cactaatatc atagtgctgt gatgatggac aattacatag taccgataac     2760

agccatgcac tgtgcaaagc atgcccttct gcacaggaga gcaaggcact tgcagtagtg     2820

atctatgcca gcaaaacatc attttgagac aaacattttt gtggcagatg tttttcctaa     2880

aaagtactat atcatccaag aaatatttga gtaaaatccc ttgttctttt gggtgacatt     2940

aactgacatt tgcttttttt caagacctaa tagaaaataa gaaagcccat aatgtattta     3000

gaaacaggaa tcctcagagc aattctctgt attctcatat aatttcaatg taaaacagaa     3060

aacatattga tgtgttggtg ataggcttga attattaaaa acttcaaaaa catcctaagt     3120

gtttcttttt tgctcaacgt tgtcaactat agtaggtctc ccttgtggtg taatgaattg     3180

cccccaaact attatcttaa aacaacaaac atttattatc ttatagcatt tctgagggtc     3240

aggatctggg actggcttag tggagttgtt ctggatcagg gcctttggaa agttgtagtt     3300

aacttgtccc cagggctgcc atcatctcaa ggctcgggtg gggctggaga aaatctgctt     3360

ctcagctcac tcacggcggt tgccaggcct ccattcttta ggatgctaga aaaactttca     3420

taaaatgtca tctggcttct cctagagcaa tgatactgag agagaaagca catgagagaa     3480

agagcgaggg aacttggatg taagccacag tctttgaaaa cctaatcaca gaagtgacat     3540

ctcttcttcc acatgatgtt ggtcacatgg accaacaatg gcacaacgtg gacagaatca     3600

aacagagttg agaatatcag gaggtggggc ttcatggggg ccattttgga tgctatcata     3660

gtgaatatat gtatttatat ttatatctgt atatattgca atgtaattta aaaaatagga     3720

ttgttttcct tttctttttg ctatatgtga tatgtatttc aaaatacact cccaatagtt     3780

acgtctgaaa agcactacac taaaaaactt tctatacatt gaataattaa attaaataat     3840

ctaa                                                                  3844


<210>  2
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Thr Gln Leu Pro Ala Tyr Val Ala Ile Leu Leu Phe Tyr Val 
1               5                   10                  15      


Ser Arg Ala Ser Cys Gln Asp Thr Phe Thr Ala Ala Val Tyr Glu His 
            20                  25                  30          


Ala Ala Ile Leu Pro Asn Ala Thr Leu Thr Pro Val Ser Arg Glu Glu 
        35                  40                  45              


Ala Leu Ala Leu Met Asn Arg Asn Leu Asp Ile Leu Glu Gly Ala Ile 
    50                  55                  60                  


Thr Ser Ala Ala Asp Gln Gly Ala His Ile Ile Val Thr Pro Glu Asp 
65                  70                  75                  80  


Ala Ile Tyr Gly Trp Asn Phe Asn Arg Asp Ser Leu Tyr Pro Tyr Leu 
                85                  90                  95      


Glu Asp Ile Pro Asp Pro Glu Val Asn Trp Ile Pro Cys Asn Asn Arg 
            100                 105                 110         


Asn Arg Phe Gly Gln Thr Pro Val Gln Glu Arg Leu Ser Cys Leu Ala 
        115                 120                 125             


Lys Asn Asn Ser Ile Tyr Val Val Ala Asn Ile Gly Asp Lys Lys Pro 
    130                 135                 140                 


Cys Asp Thr Ser Asp Pro Gln Cys Pro Pro Asp Gly Arg Tyr Gln Tyr 
145                 150                 155                 160 


Asn Thr Asp Val Val Phe Asp Ser Gln Gly Lys Leu Val Ala Arg Tyr 
                165                 170                 175     


His Lys Gln Asn Leu Phe Met Gly Glu Asn Gln Phe Asn Val Pro Lys 
            180                 185                 190         


Glu Pro Glu Ile Val Thr Phe Asn Thr Thr Phe Gly Ser Phe Gly Ile 
        195                 200                 205             


Phe Thr Cys Phe Asp Ile Leu Phe His Asp Pro Ala Val Thr Leu Val 
    210                 215                 220                 


Lys Asp Phe His Val Asp Thr Ile Val Phe Pro Thr Ala Trp Met Asn 
225                 230                 235                 240 


Val Leu Pro His Leu Ser Ala Val Glu Phe His Ser Ala Trp Ala Met 
                245                 250                 255     


Gly Met Arg Val Asn Phe Leu Ala Ser Asn Ile His Tyr Pro Ser Lys 
            260                 265                 270         


Lys Met Thr Gly Ser Gly Ile Tyr Ala Pro Asn Ser Ser Arg Ala Phe 
        275                 280                 285             


His Tyr Asp Met Lys Thr Glu Glu Gly Lys Leu Leu Leu Ser Gln Leu 
    290                 295                 300                 


Asp Ser His Pro Ser His Ser Ala Val Val Asn Trp Thr Ser Tyr Ala 
305                 310                 315                 320 


Ser Ser Ile Glu Ala Leu Ser Ser Gly Asn Lys Glu Phe Lys Gly Thr 
                325                 330                 335     


Val Phe Phe Asp Glu Phe Thr Phe Val Lys Leu Thr Gly Val Ala Gly 
            340                 345                 350         


Asn Tyr Thr Val Cys Gln Lys Asp Leu Cys Cys His Leu Ser Tyr Lys 
        355                 360                 365             


Met Ser Glu Asn Ile Pro Asn Glu Val Tyr Ala Leu Gly Ala Phe Asp 
    370                 375                 380                 


Gly Leu His Thr Val Glu Gly Arg Tyr Tyr Leu Gln Ile Cys Thr Leu 
385                 390                 395                 400 


Leu Lys Cys Lys Thr Thr Asn Leu Asn Thr Cys Gly Asp Ser Ala Glu 
                405                 410                 415     


Thr Ala Ser Thr Arg Phe Glu Met Phe Ser Leu Ser Gly Thr Phe Gly 
            420                 425                 430         


Thr Gln Tyr Val Phe Pro Glu Val Leu Leu Ser Glu Asn Gln Leu Ala 
        435                 440                 445             


Pro Gly Glu Phe Gln Val Ser Thr Asp Gly Arg Leu Phe Ser Leu Lys 
    450                 455                 460                 


Pro Thr Ser Gly Pro Val Leu Thr Val Thr Leu Phe Gly Arg Leu Tyr 
465                 470                 475                 480 


Glu Lys Asp Trp Ala Ser Asn Ala Ser Ser Gly Leu Thr Ala Gln Ala 
                485                 490                 495     


Arg Ile Ile Met Leu Ile Val Ile Ala Pro Ile Val Cys Ser Leu Ser 
            500                 505                 510         


Trp 
    


<210>  3
<211>  2000
<212>  DNA
<213>  Homo sapiens

<400>  3
agcagttaga gaagctggtg tttaccggaa actcaggaga accagccaac cacaacccct       60

gggttacctt ggcaattgca gaataaatgc attatagtta ctaaagtaaa aaattagata      120

tgcctgtttg cagattgaac tataaaaata ccattcaaag acaaatagat ctaaaaataa      180

aatggaaaaa cataaacact aattctgtaa atattatact taatgcacaa ctgaaacaaa      240

atttgccagc ttactcaata tcaaaatcta tgaacagttt ttctatttta tataatttcc      300

ctctcctctc tctggatctc gctccccagc tcattttttc ttttttttgc tctgattctt      360

tatacacctc tgttgcctct gtgataagca gcttcaaaga tggttcctaa tgctttattg      420

gatagaatac aacaaaagcg atgaggtgtt gcttccccaa ttacattacg aagcatccgt      480

ggcttccatc tccagtgggt tcacttgctg tctggctcta agggaatcca gataccataa      540

tgcgggctgc cctatggtga ggtttgcatc actaggaact catgtctctg ggcaacaacc      600

aatgaggtct tgatccctgc cgtcagccac atgagggagc ttggagctcg gaagtgaatc      660

ctcctggagt caagccttga tatagctagc cctggcagct gcttgactgc agccttgtga      720

aagagacctt gggccagagg caccagctaa actgcccctg gattcctgac ccagagaaag      780

tgggagatga tgtatttttg ctttttgaag ctgctgaatt tggggataat ttgttatata      840

gcaatagaaa atgagtaact cttttgtatt cctctttgtc ctggcttccc cattttgagg      900

aaaataaagt aaatcaaagt gtagagctga aatattcaca tgaaaataat aataaagttt      960

taaaattatt tgaatgtctt gtgttgacat tccaaaatat atgaattcca aaaatttata     1020

tgttgaagtc ctaactgtca gtatcttaga atgtaacttt tttggaaaag gggtcatttc     1080

agatctaatt agttaagatg aagttatact ggagtacagt gggcactaaa tcgaattggt     1140

cctatgattg agtctcagtc tttcagtgag cctgtacccc tgggtttatg accttcagtt     1200

ggcttttttc ttctgccctt atttggcata aaaacaaagc aggtggatca cctgaggtca     1260

gcaatttgag accagcctgc ccaacacggc gaaaccctat ctctactaaa aatacaaaaa     1320

attagcctgg cgtggtggcg ggcgcctgta atcccagcta cttgggaggc tgaggcagga     1380

gaatcacatg aacccgagag gcggaggttg cagtgagccg agatttcgcc actgcactct     1440

agcctgggtg acaagagtga aactccatct caaacaacaa caacaataaa caaacaacaa     1500

cgatgacaaa aaaagctaga gctgggattt tccctttccc tgtgttaaag attagagtgg     1560

tgtcctcaca aaaagggaaa acttggatac aggcacacac atggggagaa tagcatatga     1620

agagacacag ggagaaggca gccatctatg ggtcaaggag agaggcctgg aacacatctt     1680

tccttcaccg ccctcaggag gaaccaactc tgctgacacc ttcatctggg actcccaccc     1740

tccagaactg caaagcaata aattttttat tttttacacc acccagttta ttgtattttg     1800

ttaggcagcc ctagcgaact aatgtacata gagttcttga gttaatcttc acaaattact     1860

gcaataaggt agggtctttt gttatgtaac aatgctatga aatcatagcg ttttcttaat     1920

taacttccgt agtttaaggt actaagttct ggacaccacg tgtcttcttt ctataaatac     1980

caggacatgc tctgtttttc                                                 2000


<210>  4
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  4
cctggttctg gaatcctca                                                    19


<210>  5
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  5
tcgaacattg gtcctttttc tt                                                22


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  6
ttacagccca gatagctctt                                                   20


<210>  7
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  7
atggcttcca gcaactc                                                      17


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  8
tctgcatccc tggtgtgtaa                                                   20


<210>  9
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  9
aagttgatgg cttcaggag                                                    19


<210>  10
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  10
ctcagtggca ctttcgg                                                      17


<210>  11
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  11
caacctccca aacagagtta c                                                 21


<210>  12
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  12
ggggaaggtg aaggtcggag tca                                               23


<210>  13
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  13
agccttgacg gtgccatgga at                                                22


<210>  14
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  14
aggtgttgtt tttttaatta tatta                                             25


<210>  15
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  15
cttaactcca aaaaaattca cttcc                                             25


<210>  16
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  16
tttaaagatg gtttttaatg ttttattg                                          28


<210>  17
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  17
cccaaaatct ctttcacaaa actac                                             25


<210>  18
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  18
aggtgttgtt tttttaatta tatta                                             25


<210>  19
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  19
gttgtttggt tttaagggaa tttag                                             25


<210>  20
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer sequence

<400>  20
ttgggtaata attaatgagg ttttg                                             25


