                         SEQUENCE LISTING

<110>  Novozymes A/S
 
<120>  Methods for producing lipases

<130>  12960-WO-PCT

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1110
<212>  DNA
<213>  Rhizomucor miehei


<220>
<221>  CDS
<222>  (13)..(1101)

<220>
<221>  sig_peptide
<222>  (13)..(84)

<220>
<221>  misc_feature
<222>  (85)..(294)

<220>
<221>  mat_peptide
<222>  (295)..(930)

<400>  1
ggatccttca cc atg gtt ctc aag cag cgt gca aac tac cta gga ttt ctg       51
              Met Val Leu Lys Gln Arg Ala Asn Tyr Leu Gly Phe Leu         
                              -90                 -85                     

att gta ttc ttc acg gcc ttc ctg gtg gaa gcg gta ccc atc aag aga         99
Ile Val Phe Phe Thr Ala Phe Leu Val Glu Ala Val Pro Ile Lys Arg           
    -80                 -75                 -70                           

caa tcg aat tcc acg gtc gac agt ctg ccg cct ctc atc ccc tcg aga        147
Gln Ser Asn Ser Thr Val Asp Ser Leu Pro Pro Leu Ile Pro Ser Arg           
-65                 -60                 -55                 -50           

acc tcg gca cct tca tca tca cca agc aca acc gac cct gaa gct cca        195
Thr Ser Ala Pro Ser Ser Ser Pro Ser Thr Thr Asp Pro Glu Ala Pro           
                -45                 -40                 -35               

gcc atg agt cgc aat gga ccg ctg ccc tcg gat gta gag act aaa tat        243
Ala Met Ser Arg Asn Gly Pro Leu Pro Ser Asp Val Glu Thr Lys Tyr           
            -30                 -25                 -20                   

ggc atg gct ttg aat gct act tcc tat ccg gat tct gtg gtc caa gca        291
Gly Met Ala Leu Asn Ala Thr Ser Tyr Pro Asp Ser Val Val Gln Ala           
        -15                 -10                 -5                        

atg agc att gat ggt ggt atc cgc gct gcg acc tcg caa gaa atc aat        339
Met Ser Ile Asp Gly Gly Ile Arg Ala Ala Thr Ser Gln Glu Ile Asn           
-1  1               5                   10                  15            

gaa ttg act tat tac act aca cta tct gcc aac tcg tac tgc cgc act        387
Glu Leu Thr Tyr Tyr Thr Thr Leu Ser Ala Asn Ser Tyr Cys Arg Thr           
                20                  25                  30                

gtc att cct gga gct acc tgg gac tgt atc cac tgt gat gca acg gag        435
Val Ile Pro Gly Ala Thr Trp Asp Cys Ile His Cys Asp Ala Thr Glu           
            35                  40                  45                    

gat ctc aag att atc aag act tgg agc acg ctc atc tat gat aca aat        483
Asp Leu Lys Ile Ile Lys Thr Trp Ser Thr Leu Ile Tyr Asp Thr Asn           
        50                  55                  60                        

gca atg gtt gca cgt ggt gac agc gaa aaa act atc tat atc gtt ttc        531
Ala Met Val Ala Arg Gly Asp Ser Glu Lys Thr Ile Tyr Ile Val Phe           
    65                  70                  75                            

cga ggt tcg agc tct atc cgc aac tgg att gct gat ctc acc ttt gtg        579
Arg Gly Ser Ser Ser Ile Arg Asn Trp Ile Ala Asp Leu Thr Phe Val           
80                  85                  90                  95            

cca gtt tca tat cct ccg gtc agt ggt aca aaa gta cac aag gga ttc        627
Pro Val Ser Tyr Pro Pro Val Ser Gly Thr Lys Val His Lys Gly Phe           
                100                 105                 110               

ctg gac agt tac ggg gaa gtt caa aac gag ctt gtt gct act gtt ctt        675
Leu Asp Ser Tyr Gly Glu Val Gln Asn Glu Leu Val Ala Thr Val Leu           
            115                 120                 125                   

gat caa ttc aag caa tat cca agc tac aag gtt gct gtt aca ggt cac        723
Asp Gln Phe Lys Gln Tyr Pro Ser Tyr Lys Val Ala Val Thr Gly His           
        130                 135                 140                       

tca ctc ggt ggt gct act gcg ttg ctt tgc gcc ctg gat ctc tat caa        771
Ser Leu Gly Gly Ala Thr Ala Leu Leu Cys Ala Leu Asp Leu Tyr Gln           
    145                 150                 155                           

cga gaa gaa gga ctc tca tcc agc aac ttg ttc ctt tac act caa ggt        819
Arg Glu Glu Gly Leu Ser Ser Ser Asn Leu Phe Leu Tyr Thr Gln Gly           
160                 165                 170                 175           

caa cca cgg gta ggc gac cct gcc ttt gcc aac tac gtt gtt agc acc        867
Gln Pro Arg Val Gly Asp Pro Ala Phe Ala Asn Tyr Val Val Ser Thr           
                180                 185                 190               

ggc att cct tac agg cgc acg gtc aat gaa cga gat atc gtt cct cat        915
Gly Ile Pro Tyr Arg Arg Thr Val Asn Glu Arg Asp Ile Val Pro His           
            195                 200                 205                   

ctt cca cct gct gct ttt ggt ttt ctc cac gct ggc gag gag tat tgg        963
Leu Pro Pro Ala Ala Phe Gly Phe Leu His Ala Gly Glu Glu Tyr Trp           
        210                 215                 220                       

att act gac aat agc cca gag act gtt cag gtc tgc aca agc gat ctg       1011
Ile Thr Asp Asn Ser Pro Glu Thr Val Gln Val Cys Thr Ser Asp Leu           
    225                 230                 235                           

gaa acc tct gat tgc tct aac agc att gtt ccc ttc aca agt gtt ctt       1059
Glu Thr Ser Asp Cys Ser Asn Ser Ile Val Pro Phe Thr Ser Val Leu           
240                 245                 250                 255           

gac cat ctc tcg tac ttt ggt atc aac aca ggc ctc tgt act taactcgag     1110
Asp His Leu Ser Tyr Phe Gly Ile Asn Thr Gly Leu Cys Thr                   
                260                 265                                   


<210>  2
<211>  363
<212>  PRT
<213>  Rhizomucor miehei

<400>  2

Met Val Leu Lys Gln Arg Ala Asn Tyr Leu Gly Phe Leu Ile Val Phe 
                -90                 -85                 -80     


Phe Thr Ala Phe Leu Val Glu Ala Val Pro Ile Lys Arg Gln Ser Asn 
            -75                 -70                 -65         


Ser Thr Val Asp Ser Leu Pro Pro Leu Ile Pro Ser Arg Thr Ser Ala 
        -60                 -55                 -50             


Pro Ser Ser Ser Pro Ser Thr Thr Asp Pro Glu Ala Pro Ala Met Ser 
    -45                 -40                 -35                 


Arg Asn Gly Pro Leu Pro Ser Asp Val Glu Thr Lys Tyr Gly Met Ala 
-30                 -25                 -20                 -15 


Leu Asn Ala Thr Ser Tyr Pro Asp Ser Val Val Gln Ala Met Ser Ile 
                -10                 -5              -1  1       


Asp Gly Gly Ile Arg Ala Ala Thr Ser Gln Glu Ile Asn Glu Leu Thr 
        5                   10                  15              


Tyr Tyr Thr Thr Leu Ser Ala Asn Ser Tyr Cys Arg Thr Val Ile Pro 
    20                  25                  30                  


Gly Ala Thr Trp Asp Cys Ile His Cys Asp Ala Thr Glu Asp Leu Lys 
35                  40                  45                  50  


Ile Ile Lys Thr Trp Ser Thr Leu Ile Tyr Asp Thr Asn Ala Met Val 
                55                  60                  65      


Ala Arg Gly Asp Ser Glu Lys Thr Ile Tyr Ile Val Phe Arg Gly Ser 
            70                  75                  80          


Ser Ser Ile Arg Asn Trp Ile Ala Asp Leu Thr Phe Val Pro Val Ser 
        85                  90                  95              


Tyr Pro Pro Val Ser Gly Thr Lys Val His Lys Gly Phe Leu Asp Ser 
    100                 105                 110                 


Tyr Gly Glu Val Gln Asn Glu Leu Val Ala Thr Val Leu Asp Gln Phe 
115                 120                 125                 130 


Lys Gln Tyr Pro Ser Tyr Lys Val Ala Val Thr Gly His Ser Leu Gly 
                135                 140                 145     


Gly Ala Thr Ala Leu Leu Cys Ala Leu Asp Leu Tyr Gln Arg Glu Glu 
            150                 155                 160         


Gly Leu Ser Ser Ser Asn Leu Phe Leu Tyr Thr Gln Gly Gln Pro Arg 
        165                 170                 175             


Val Gly Asp Pro Ala Phe Ala Asn Tyr Val Val Ser Thr Gly Ile Pro 
    180                 185                 190                 


Tyr Arg Arg Thr Val Asn Glu Arg Asp Ile Val Pro His Leu Pro Pro 
195                 200                 205                 210 


Ala Ala Phe Gly Phe Leu His Ala Gly Glu Glu Tyr Trp Ile Thr Asp 
                215                 220                 225     


Asn Ser Pro Glu Thr Val Gln Val Cys Thr Ser Asp Leu Glu Thr Ser 
            230                 235                 240         


Asp Cys Ser Asn Ser Ile Val Pro Phe Thr Ser Val Leu Asp His Leu 
        245                 250                 255             


Ser Tyr Phe Gly Ile Asn Thr Gly Leu Cys Thr 
    260                 265                 


<210>  3
<211>  269
<212>  PRT
<213>  Rhizomucor miehei

<400>  3

Ser Ile Asp Gly Gly Ile Arg Ala Ala Thr Ser Gln Glu Ile Asn Glu 
1               5                   10                  15      


Leu Thr Tyr Tyr Thr Thr Leu Ser Ala Asn Ser Tyr Cys Arg Thr Val 
            20                  25                  30          


Ile Pro Gly Ala Thr Trp Asp Cys Ile His Cys Asp Ala Thr Glu Asp 
        35                  40                  45              


Leu Lys Ile Ile Lys Thr Trp Ser Thr Leu Ile Tyr Asp Thr Asn Ala 
    50                  55                  60                  


Met Val Ala Arg Gly Asp Ser Glu Lys Thr Ile Tyr Ile Val Phe Arg 
65                  70                  75                  80  


Gly Ser Ser Ser Ile Arg Asn Trp Ile Ala Asp Leu Thr Phe Val Pro 
                85                  90                  95      


Val Ser Tyr Pro Pro Val Ser Gly Thr Lys Val His Lys Gly Phe Leu 
            100                 105                 110         


Asp Ser Tyr Gly Glu Val Gln Asn Glu Leu Val Ala Thr Val Leu Asp 
        115                 120                 125             


Gln Phe Lys Gln Tyr Pro Ser Tyr Lys Val Ala Val Thr Gly His Ser 
    130                 135                 140                 


Leu Gly Gly Ala Thr Ala Leu Leu Cys Ala Leu Asp Leu Tyr Gln Arg 
145                 150                 155                 160 


Glu Glu Gly Leu Ser Ser Ser Asn Leu Phe Leu Tyr Thr Gln Gly Gln 
                165                 170                 175     


Pro Arg Val Gly Asp Pro Ala Phe Ala Asn Tyr Val Val Ser Thr Gly 
            180                 185                 190         


Ile Pro Tyr Arg Arg Thr Val Asn Glu Arg Asp Ile Val Pro His Leu 
        195                 200                 205             


Pro Pro Ala Ala Phe Gly Phe Leu His Ala Gly Glu Glu Tyr Trp Ile 
    210                 215                 220                 


Thr Asp Asn Ser Pro Glu Thr Val Gln Val Cys Thr Ser Asp Leu Glu 
225                 230                 235                 240 


Thr Ser Asp Cys Ser Asn Ser Ile Val Pro Phe Thr Ser Val Leu Asp 
                245                 250                 255     


His Leu Ser Tyr Phe Gly Ile Asn Thr Gly Leu Cys Thr 
            260                 265                 


<210>  4
<211>  70
<212>  PRT
<213>  Rhizomucor miehei

<400>  4

Val Pro Ile Lys Arg Gln Ser Asn Ser Thr Val Asp Ser Leu Pro Pro 
1               5                   10                  15      


Leu Ile Pro Ser Arg Thr Ser Ala Pro Ser Ser Ser Pro Ser Thr Thr 
            20                  25                  30          


Asp Pro Glu Ala Pro Ala Met Ser Arg Asn Gly Pro Leu Pro Ser Asp 
        35                  40                  45              


Val Glu Thr Lys Tyr Gly Met Ala Leu Asn Ala Thr Ser Tyr Pro Asp 
    50                  55                  60                  


Ser Val Val Gln Ala Met 
65                  70  


<210>  5
<211>  269
<212>  PRT
<213>  Thermomyces lanuginosus

<400>  5

Glu Val Ser Gln Asp Leu Phe Asn Gln Phe Asn Leu Phe Ala Gln Tyr 
1               5                   10                  15      


Ser Ala Ala Ala Tyr Cys Gly Lys Asn Asn Asp Ala Pro Ala Gly Thr 
            20                  25                  30          


Asn Ile Thr Cys Thr Gly Asn Ala Cys Pro Glu Val Glu Lys Ala Asp 
        35                  40                  45              


Ala Thr Phe Leu Tyr Ser Phe Glu Asp Ser Gly Val Gly Asp Val Thr 
    50                  55                  60                  


Gly Phe Leu Ala Leu Asp Asn Thr Asn Lys Leu Ile Val Leu Ser Phe 
65                  70                  75                  80  


Arg Gly Ser Arg Ser Ile Glu Asn Trp Ile Gly Asn Leu Asn Phe Asp 
                85                  90                  95      


Leu Lys Glu Ile Asn Asp Ile Cys Ser Gly Cys Arg Gly His Asp Gly 
            100                 105                 110         


Phe Thr Ser Ser Trp Arg Ser Val Ala Asp Thr Leu Arg Gln Lys Val 
        115                 120                 125             


Glu Asp Ala Val Arg Glu His Pro Asp Tyr Arg Val Val Phe Thr Gly 
    130                 135                 140                 


His Ser Leu Gly Gly Ala Leu Ala Thr Val Ala Gly Ala Asp Leu Arg 
145                 150                 155                 160 


Gly Asn Gly Tyr Asp Ile Asp Val Phe Ser Tyr Gly Ala Pro Arg Val 
                165                 170                 175     


Gly Asn Arg Ala Phe Ala Glu Phe Leu Thr Val Gln Thr Gly Gly Thr 
            180                 185                 190         


Leu Tyr Arg Ile Thr His Thr Asn Asp Ile Val Pro Arg Leu Pro Pro 
        195                 200                 205             


Arg Glu Phe Gly Tyr Ser His Ser Ser Pro Glu Tyr Trp Ile Lys Ser 
    210                 215                 220                 


Gly Thr Leu Val Pro Val Arg Arg Arg Asp Ile Val Lys Ile Glu Gly 
225                 230                 235                 240 


Ile Asp Ala Thr Gly Gly Asn Asn Gln Pro Asn Ile Pro Asp Ile Pro 
                245                 250                 255     


Ala His Leu Trp Tyr Phe Gly Leu Ile Gly Thr Cys Leu 
            260                 265                 


<210>  6
<211>  384
<212>  PRT
<213>  Mucor circinelloides

<400>  6

Met Val Ser Phe Val Ser Ile Ser Gln Gly Ile Ser Leu Phe Ile Val 
1               5                   10                  15      


Val Ser Ser Met Leu Thr Gly Ser Ala His Ala Ala Pro Ala Ser Ser 
            20                  25                  30          


His Ser Asn Ser Ser Lys Asn Ala Thr Thr Ser Asp Ala Ser Thr Phe 
        35                  40                  45              


Thr Leu Pro Pro Ile Ile Ser Ser Arg Val Thr Pro Pro Lys Val Pro 
    50                  55                  60                  


Ser Gly Ser His Asn Val Glu Asp Ala Asn Val Ala Lys Asn Lys Lys 
65                  70                  75                  80  


Trp Phe Glu Ala His Gly Gly Lys Leu Asn Val Thr Lys Arg Ala Asp 
                85                  90                  95      


Glu Thr Val Gly Gly Tyr Thr Met Asp Leu Pro Ser Asn Ala Pro Pro 
            100                 105                 110         


Leu Pro Ala Val Pro Ser Thr Ser Thr Val Val Ile Ala Ser Thr Ala 
        115                 120                 125             


Gln Ile Ser Glu Phe Lys Lys Tyr Ala Gly Ile Ala Ser Thr Ala Tyr 
    130                 135                 140                 


Cys Arg Ser Val Val Pro Leu Asn Gln Trp Ser Cys Thr Asn Cys Leu 
145                 150                 155                 160 


Lys Phe Val Pro Asp Gly Lys Leu Ile Lys Thr Phe Thr Ser Leu Val 
                165                 170                 175     


Thr Asp Thr Asn Gly Phe Val Leu Arg Ser Asp Ala Gln Lys Thr Ile 
            180                 185                 190         


Tyr Val Val Phe Arg Gly Thr Asn Ser Ile Arg Ser Ala Ile Thr Asp 
        195                 200                 205             


Leu Val Phe Glu Leu Thr Asn Tyr Thr Pro Val Ser Gly Ala Lys Val 
    210                 215                 220                 


His Thr Gly Phe Tyr Ala Ser Tyr Lys Ala Val Val Ser Asp Tyr Phe 
225                 230                 235                 240 


Pro Ala Val Gln Ser Gln Leu Thr Ala Tyr Pro Gly Tyr Lys Val Ile 
                245                 250                 255     


Val Thr Gly His Ser Leu Gly Gly Ala Gln Ala Leu Leu Ala Gly Met 
            260                 265                 270         


Asp Leu Tyr Gln Arg Glu Pro Arg Leu Ser Lys Ser Asn Leu Ala Ile 
        275                 280                 285             


Tyr Thr Val Gly Cys Pro Arg Val Gly Asn Pro Ala Phe Ala Tyr Tyr 
    290                 295                 300                 


Val Asp Ser Thr Gly Ile Thr Phe Ser Arg Ser Val Asn Asn Arg Asp 
305                 310                 315                 320 


Ile Val Pro His Val Pro Pro Gln Ala Trp Gly Phe Leu His Pro Gly 
                325                 330                 335     


Val Glu Ala Trp Ala Arg Ser Ser Ser Asn Val Gln Ile Cys Thr Pro 
            340                 345                 350         


Asn Ile Glu Thr Gly Leu Cys Ser Asn Ser Ile Val Pro Phe Thr Ser 
        355                 360                 365             


Phe Thr Asp His Leu Thr Tyr Tyr Asp Leu Asn Glu Gly Leu Cys Leu 
    370                 375                 380                 


<210>  7
<211>  389
<212>  PRT
<213>  Rhizopus microsporus var. chinensis

<400>  7

Met Val Ser Phe Ile Ser Ile Ser Gln Gly Val Ser Leu Cys Leu Leu 
1               5                   10                  15      


Val Ser Ser Met Met Leu Gly Ser Ser Ala Val Pro Val Ala Gly His 
            20                  25                  30          


Lys Gly Ser Val Lys Ala Thr Asn Gly Thr Asp Phe Gln Leu Pro Pro 
        35                  40                  45              


Leu Ile Ser Ser Arg Cys Thr Pro Pro Ser His Pro Glu Thr Thr Gly 
    50                  55                  60                  


Asp Pro Asp Ala Glu Ala Tyr Tyr Ile Asn Lys Ser Val Gln Trp Tyr 
65                  70                  75                  80  


Gln Ala His Gly Gly Asn Tyr Thr Ala Leu Ile Lys Arg Asp Thr Glu 
                85                  90                  95      


Thr Val Gly Gly Met Thr Leu Asp Leu Pro Glu Asn Pro Pro Pro Ile 
            100                 105                 110         


Pro Ala Thr Ser Thr Ala Pro Ser Ser Asp Ser Gly Glu Val Val Thr 
        115                 120                 125             


Ala Thr Ala Ala Gln Ile Lys Glu Leu Thr Asn Tyr Ala Gly Val Ala 
    130                 135                 140                 


Ala Thr Ala Tyr Cys Arg Ser Val Val Pro Gly Thr Lys Trp Asp Cys 
145                 150                 155                 160 


Lys Gln Cys Leu Lys Tyr Val Pro Asp Gly Lys Leu Ile Lys Thr Phe 
                165                 170                 175     


Thr Ser Leu Leu Thr Asp Thr Asn Gly Phe Ile Leu Arg Ser Asp Ala 
            180                 185                 190         


Gln Lys Thr Ile Tyr Val Thr Phe Arg Gly Thr Asn Ser Phe Arg Ser 
        195                 200                 205             


Ala Ile Thr Asp Met Val Phe Thr Phe Thr Asp Tyr Ser Pro Val Lys 
    210                 215                 220                 


Gly Ala Lys Val His Ala Gly Phe Leu Ser Ser Tyr Asn Gln Val Val 
225                 230                 235                 240 


Lys Asp Tyr Phe Pro Val Val Gln Asp Gln Leu Thr Ala Tyr Pro Asp 
                245                 250                 255     


Tyr Lys Val Ile Val Thr Gly His Ser Leu Gly Gly Ala Gln Ala Leu 
            260                 265                 270         


Leu Ala Gly Met Asp Leu Tyr Gln Arg Glu Lys Arg Leu Ser Pro Lys 
        275                 280                 285             


Asn Leu Ser Ile Tyr Thr Val Gly Cys Pro Arg Val Gly Asn Asn Ala 
    290                 295                 300                 


Phe Ala Tyr Tyr Val Asp Ser Thr Gly Ile Pro Phe His Arg Thr Val 
305                 310                 315                 320 


His Lys Arg Asp Ile Val Pro His Val Pro Pro Gln Ala Phe Gly Tyr 
                325                 330                 335     


Leu His Pro Gly Val Glu Ser Trp Ile Lys Glu Asp Pro Ala Asp Val 
            340                 345                 350         


Gln Ile Cys Thr Ser Asn Ile Glu Thr Lys Gln Cys Ser Asn Ser Ile 
        355                 360                 365             


Val Pro Phe Thr Ser Ile Ala Asp His Leu Thr Tyr Phe Gly Ile Asn 
    370                 375                 380                 


Glu Gly Ser Cys Leu 
385                 


<210>  8
<211>  392
<212>  PRT
<213>  Rhizopus oryzae

<400>  8

Met Val Ser Phe Ile Ser Ile Ser Gln Gly Val Ser Leu Cys Leu Leu 
1               5                   10                  15      


Val Ser Ser Met Met Leu Gly Ser Ser Ala Val Pro Val Ser Gly Lys 
            20                  25                  30          


Ser Gly Ser Ser Asn Thr Ala Val Ser Ala Ser Asp Asn Ala Ala Leu 
        35                  40                  45              


Pro Pro Leu Ile Ser Ser Arg Cys Ala Pro Pro Ser Asn Lys Gly Ser 
    50                  55                  60                  


Lys Ser Asp Leu Gln Ala Glu Pro Tyr Asn Met Gln Lys Asn Thr Glu 
65                  70                  75                  80  


Trp Tyr Glu Ser His Gly Gly Asn Leu Thr Ser Ile Gly Lys Arg Asp 
                85                  90                  95      


Asp Asn Leu Val Gly Gly Met Thr Leu Asp Leu Pro Ser Asp Ala Pro 
            100                 105                 110         


Pro Ile Ser Leu Ser Ser Ser Thr Asn Ser Ala Ser Asp Gly Gly Lys 
        115                 120                 125             


Val Val Ala Ala Thr Thr Ala Gln Ile Gln Glu Phe Thr Lys Tyr Ala 
    130                 135                 140                 


Gly Ile Ala Ala Thr Ala Tyr Cys Arg Ser Val Val Pro Gly Asn Lys 
145                 150                 155                 160 


Trp Asp Cys Val Gln Cys Gln Lys Trp Val Pro Asp Gly Lys Ile Ile 
                165                 170                 175     


Thr Thr Phe Thr Ser Leu Leu Ser Asp Thr Asn Gly Tyr Val Leu Arg 
            180                 185                 190         


Ser Asp Lys Gln Lys Thr Ile Tyr Leu Val Phe Arg Gly Thr Asn Ser 
        195                 200                 205             


Phe Arg Ser Ala Ile Thr Asp Ile Val Phe Asn Phe Ser Asp Tyr Lys 
    210                 215                 220                 


Pro Val Lys Gly Ala Lys Val His Ala Gly Phe Leu Ser Ser Tyr Glu 
225                 230                 235                 240 


Gln Val Val Asn Asp Tyr Phe Pro Val Val Gln Glu Gln Leu Thr Ala 
                245                 250                 255     


His Pro Thr Tyr Lys Val Ile Val Thr Gly His Ser Leu Gly Gly Ala 
            260                 265                 270         


Gln Ala Leu Leu Ala Gly Met Asp Leu Tyr Gln Arg Glu Pro Arg Leu 
        275                 280                 285             


Ser Pro Lys Asn Leu Ser Ile Phe Thr Val Gly Gly Pro Arg Val Gly 
    290                 295                 300                 


Asn Pro Thr Phe Ala Tyr Tyr Val Glu Ser Thr Gly Ile Pro Phe Gln 
305                 310                 315                 320 


Arg Thr Val His Lys Arg Asp Ile Val Pro His Val Pro Pro Gln Ser 
                325                 330                 335     


Phe Gly Phe Leu His Pro Gly Val Glu Ser Trp Ile Lys Ser Gly Thr 
            340                 345                 350         


Ser Asn Val Gln Ile Cys Thr Ser Glu Ile Glu Thr Lys Asp Cys Ser 
        355                 360                 365             


Asn Ser Ile Val Pro Phe Thr Ser Ile Leu Asp His Leu Ser Tyr Phe 
    370                 375                 380                 


Asp Ile Asn Glu Gly Ser Cys Leu 
385                 390         


