                         SEQUENCE LISTING

<110>  Spring BioScience Corporation
       F. Hoffmann-La Roche AG
 
<120>  ANTI- INDOLEAMINE 2,3-DIOXYGENASE 1 ANTIBODIES AND DIAGNOSTIC 
       USES THEREOF

<130>  P32152-WO

<150>  US 62/004,594
<151>  2014-05-29

<150>  US 62/067,742
<151>  2014-10-23

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid residues 392-403 of human IDO1

<400>  1

Arg Ser Thr Thr Glu Lys Ser Leu Leu Lys Glu Gly 
1               5                   10          


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 sequence

<400>  2

Thr Asn Tyr Trp Ile Cys 
1               5       


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2

<400>  3

Cys Ile Tyr Val Gly Gly Arg Gly Ser Ile Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3

<400>  4

Asp Leu Thr Thr Ala Tyr Gly Ala Thr Asp Leu Arg Phe 
1               5                   10              


<210>  5
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H1

<400>  5

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser 
            20                  25                  30  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H2

<400>  6

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Thr Ala 
1               5                   10                  


<210>  7
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H3

<400>  7

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu Gln Met 
1               5                   10                  15      


Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H4

<400>  8

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1

<400>  9

Gln Ser Ser Gln Ser Val Gly Asp Asn Asn Arg Leu Ser 
1               5                   10              


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2

<400>  10

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3

<400>  11

Leu Gly Glu Phe Ser Gly Ser Asp Glu Asp Val 
1               5                   10      


<210>  12
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-L1

<400>  12

Asp Val Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys 
            20              


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-L2

<400>  13

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  14
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-L3

<400>  14

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-L4

<400>  15

Phe Gly Gly Gly Thr Glu Val Val Val Lys 
1               5                   10  


<210>  16
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP260 heavy chain variable region

<400>  16

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Thr Asn 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Thr Ala Cys Ile Tyr Val Gly Gly Arg Gly Ser Ile Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Leu Thr Thr Ala Tyr Gly Ala Thr Asp Leu Arg Phe 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  17
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP260 light chain variable region

<400>  17

Asp Val Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Gln Ser Val Gly Asp Asn 
            20                  25                  30          


Asn Arg Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Ser Gly 
                85                  90                  95      


Ser Asp Glu Asp Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210>  18
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2(2)

<400>  18

Cys Ile Tyr Ile Gly Gly Arg Gly Ser Ile Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H1(2)

<400>  19

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser 
            20                  25                  30  


<210>  20
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H3(2)

<400>  20

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu Gln Met 
1               5                   10                  15      


Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Ser Cys Ala Arg 
            20                  25                  30      


<210>  21
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J6H12L16 heavy chain variable region

<400>  21

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Thr Asn 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Thr Ala Cys Ile Tyr Ile Gly Gly Arg Gly Ser Ile Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Leu Thr Thr Ala Tyr Gly Ala Thr Asp Leu Arg Phe 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  22
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J6H12L16 Light Chain Variable Region

<400>  22

Asp Val Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Gln Ser Val Gly Asp Asn 
            20                  25                  30          


Asn Arg Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Ser Gly 
                85                  90                  95      


Ser Asp Glu Asp Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210>  23
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J6H15L16 Heavy chain variable region

<400>  23

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Thr Asn 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Thr Ala Cys Ile Tyr Ile Gly Gly Arg Gly Ser Ile Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Leu Thr Thr Ala Tyr Gly Ala Thr Asp Leu Arg Phe 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  24
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J6H15L16

<400>  24

Asp Val Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Gln Ser Val Gly Asp Asn 
            20                  25                  30          


Asn Arg Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Ser Gly 
                85                  90                  95      


Ser Asp Glu Asp Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210>  25
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J6H20L16 heavy chain variable region

<400>  25

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Thr Asn 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Thr Ala Cys Ile Tyr Ile Gly Gly Arg Gly Ser Ile Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Ser 
                85                  90                  95      


Cys Ala Arg Asp Leu Thr Thr Ala Tyr Gly Ala Thr Asp Leu Arg Phe 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  26
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J6H20L16 Light chain variable region

<400>  26

Asp Val Val Met Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Gln Ser Val Gly Asp Asn 
            20                  25                  30          


Asn Arg Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Ser Gly 
                85                  90                  95      


Ser Asp Glu Asp Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210>  27
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala His Ala Met Glu Asn Ser Trp Thr Ile Ser Lys Glu Tyr His 
1               5                   10                  15      


Ile Asp Glu Glu Val Gly Phe Ala Leu Pro Asn Pro Gln Glu Asn Leu 
            20                  25                  30          


Pro Asp Phe Tyr Asn Asp Trp Met Phe Ile Ala Lys His Leu Pro Asp 
        35                  40                  45              


Leu Ile Glu Ser Gly Gln Leu Arg Glu Arg Val Glu Lys Leu Asn Met 
    50                  55                  60                  


Leu Ser Ile Asp His Leu Thr Asp His Lys Ser Gln Arg Leu Ala Arg 
65                  70                  75                  80  


Leu Val Leu Gly Cys Ile Thr Met Ala Tyr Val Trp Gly Lys Gly His 
                85                  90                  95      


Gly Asp Val Arg Lys Val Leu Pro Arg Asn Ile Ala Val Pro Tyr Cys 
            100                 105                 110         


Gln Leu Ser Lys Lys Leu Glu Leu Pro Pro Ile Leu Val Tyr Ala Asp 
        115                 120                 125             


Cys Val Leu Ala Asn Trp Lys Lys Lys Asp Pro Asn Lys Pro Leu Thr 
    130                 135                 140                 


Tyr Glu Asn Met Asp Val Leu Phe Ser Phe Arg Asp Gly Asp Cys Ser 
145                 150                 155                 160 


Lys Gly Phe Phe Leu Val Ser Leu Leu Val Glu Ile Ala Ala Ala Ser 
                165                 170                 175     


Ala Ile Lys Val Ile Pro Thr Val Phe Lys Ala Met Gln Met Gln Glu 
            180                 185                 190         


Arg Asp Thr Leu Leu Lys Ala Leu Leu Glu Ile Ala Ser Cys Leu Glu 
        195                 200                 205             


Lys Ala Leu Gln Val Phe His Gln Ile His Asp His Val Asn Pro Lys 
    210                 215                 220                 


Ala Phe Phe Ser Val Leu Arg Ile Tyr Leu Ser Gly Trp Lys Gly Asn 
225                 230                 235                 240 


Pro Gln Leu Ser Asp Gly Leu Val Tyr Glu Gly Phe Trp Glu Asp Pro 
                245                 250                 255     


Lys Glu Phe Ala Gly Gly Ser Ala Gly Gln Ser Ser Val Phe Gln Cys 
            260                 265                 270         


Phe Asp Val Leu Leu Gly Ile Gln Gln Thr Ala Gly Gly Gly His Ala 
        275                 280                 285             


Ala Gln Phe Leu Gln Asp Met Arg Arg Tyr Met Pro Pro Ala His Arg 
    290                 295                 300                 


Asn Phe Leu Cys Ser Leu Glu Ser Asn Pro Ser Val Arg Glu Phe Val 
305                 310                 315                 320 


Leu Ser Lys Gly Asp Ala Gly Leu Arg Glu Ala Tyr Asp Ala Cys Val 
                325                 330                 335     


Lys Ala Leu Val Ser Leu Arg Ser Tyr His Leu Gln Ile Val Thr Lys 
            340                 345                 350         


Tyr Ile Leu Ile Pro Ala Ser Gln Gln Pro Lys Glu Asn Lys Thr Ser 
        355                 360                 365             


Glu Asp Pro Ser Lys Leu Glu Ala Lys Gly Thr Gly Gly Thr Asp Leu 
    370                 375                 380                 


Met Asn Phe Leu Lys Thr Val Arg Ser Thr Thr Glu Lys Ser Leu Leu 
385                 390                 395                 400 


Lys Glu Gly 
            


