                         SEQUENCE LISTING

<110>  University of Leicester
 
<120>  SENESCENT CELL BIOMARKERS

<130>  AXH/GOA/72728PCT1

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  1337
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Pro Ala Ala Arg Glu Ala Arg Leu Pro Pro Arg Ser Pro Gly 
1               5                   10                  15      


Leu Arg Trp Ala Leu Pro Leu Leu Leu Leu Leu Leu Arg Leu Gly Gln 
            20                  25                  30          


Ile Leu Cys Ala Gly Gly Thr Pro Ser Pro Ile Pro Asp Pro Ser Val 
        35                  40                  45              


Ala Thr Val Ala Thr Gly Glu Asn Gly Ile Thr Gln Ile Ser Ser Thr 
    50                  55                  60                  


Ala Glu Ser Phe His Lys Gln Asn Gly Thr Gly Thr Pro Gln Val Glu 
65                  70                  75                  80  


Thr Asn Thr Ser Glu Asp Gly Glu Ser Ser Gly Ala Asn Asp Ser Leu 
                85                  90                  95      


Arg Thr Pro Glu Gln Gly Ser Asn Gly Thr Asp Gly Ala Ser Gln Lys 
            100                 105                 110         


Thr Pro Ser Ser Thr Gly Pro Ser Pro Val Phe Asp Ile Lys Ala Val 
        115                 120                 125             


Ser Ile Ser Pro Thr Asn Val Ile Leu Thr Trp Lys Ser Asn Asp Thr 
    130                 135                 140                 


Ala Ala Ser Glu Tyr Lys Tyr Val Val Lys His Lys Met Glu Asn Glu 
145                 150                 155                 160 


Lys Thr Ile Thr Val Val His Gln Pro Trp Cys Asn Ile Thr Gly Leu 
                165                 170                 175     


Arg Pro Ala Thr Ser Tyr Val Phe Ser Ile Thr Pro Gly Ile Gly Asn 
            180                 185                 190         


Glu Thr Trp Gly Asp Pro Arg Val Ile Lys Val Ile Thr Glu Pro Ile 
        195                 200                 205             


Pro Val Ser Asp Leu Arg Val Ala Leu Thr Gly Val Arg Lys Ala Ala 
    210                 215                 220                 


Leu Ser Trp Ser Asn Gly Asn Gly Thr Ala Ser Cys Arg Val Leu Leu 
225                 230                 235                 240 


Glu Ser Ile Gly Ser His Glu Glu Leu Thr Gln Asp Ser Arg Leu Gln 
                245                 250                 255     


Val Asn Ile Ser Gly Leu Lys Pro Gly Val Gln Tyr Asn Ile Asn Pro 
            260                 265                 270         


Tyr Leu Leu Gln Ser Asn Lys Thr Lys Gly Asp Pro Leu Gly Thr Glu 
        275                 280                 285             


Gly Gly Leu Asp Ala Ser Asn Thr Glu Arg Ser Arg Ala Gly Ser Pro 
    290                 295                 300                 


Thr Ala Pro Val His Asp Glu Ser Leu Val Gly Pro Val Asp Pro Ser 
305                 310                 315                 320 


Ser Gly Gln Gln Ser Arg Asp Thr Glu Val Leu Leu Val Gly Leu Glu 
                325                 330                 335     


Pro Gly Thr Arg Tyr Asn Ala Thr Val Tyr Ser Gln Ala Ala Asn Gly 
            340                 345                 350         


Thr Glu Gly Gln Pro Gln Ala Ile Glu Phe Arg Thr Asn Ala Ile Gln 
        355                 360                 365             


Val Phe Asp Val Thr Ala Val Asn Ile Ser Ala Thr Ser Leu Thr Leu 
    370                 375                 380                 


Ile Trp Lys Val Ser Asp Asn Glu Ser Ser Ser Asn Tyr Thr Tyr Lys 
385                 390                 395                 400 


Ile His Val Ala Gly Glu Thr Asp Ser Ser Asn Leu Asn Val Ser Glu 
                405                 410                 415     


Pro Arg Ala Val Ile Pro Gly Leu Arg Ser Ser Thr Phe Tyr Asn Ile 
            420                 425                 430         


Thr Val Cys Pro Val Leu Gly Asp Ile Glu Gly Thr Pro Gly Phe Leu 
        435                 440                 445             


Gln Val His Thr Pro Pro Val Pro Val Ser Asp Phe Arg Val Thr Val 
    450                 455                 460                 


Val Ser Thr Thr Glu Ile Gly Leu Ala Trp Ser Ser His Asp Ala Glu 
465                 470                 475                 480 


Ser Phe Gln Met His Ile Thr Gln Glu Gly Ala Gly Asn Ser Arg Val 
                485                 490                 495     


Glu Ile Thr Thr Asn Gln Ser Ile Ile Ile Gly Gly Leu Phe Pro Gly 
            500                 505                 510         


Thr Lys Tyr Cys Phe Glu Ile Val Pro Lys Gly Pro Asn Gly Thr Glu 
        515                 520                 525             


Gly Ala Ser Arg Thr Val Cys Asn Arg Thr Val Pro Ser Ala Val Phe 
    530                 535                 540                 


Asp Ile His Val Val Tyr Val Thr Thr Thr Glu Met Trp Leu Asp Trp 
545                 550                 555                 560 


Lys Ser Pro Asp Gly Ala Ser Glu Tyr Val Tyr His Leu Val Ile Glu 
                565                 570                 575     


Ser Lys His Gly Ser Asn His Thr Ser Thr Tyr Asp Lys Ala Ile Thr 
            580                 585                 590         


Leu Gln Gly Leu Ile Pro Gly Thr Leu Tyr Asn Ile Thr Ile Ser Pro 
        595                 600                 605             


Glu Val Asp His Val Trp Gly Asp Pro Asn Ser Thr Ala Gln Tyr Thr 
    610                 615                 620                 


Arg Pro Ser Asn Val Ser Asn Ile Asp Val Ser Thr Asn Thr Thr Ala 
625                 630                 635                 640 


Ala Thr Leu Ser Trp Gln Asn Phe Asp Asp Ala Ser Pro Thr Tyr Ser 
                645                 650                 655     


Tyr Cys Leu Leu Ile Glu Lys Ala Gly Asn Ser Ser Asn Ala Thr Gln 
            660                 665                 670         


Val Val Thr Asp Ile Gly Ile Thr Asp Ala Thr Val Thr Glu Leu Ile 
        675                 680                 685             


Pro Gly Ser Ser Tyr Thr Val Glu Ile Phe Ala Gln Val Gly Asp Gly 
    690                 695                 700                 


Ile Lys Ser Leu Glu Pro Gly Arg Lys Ser Phe Cys Thr Asp Pro Ala 
705                 710                 715                 720 


Ser Met Ala Ser Phe Asp Cys Glu Val Val Pro Lys Glu Pro Ala Leu 
                725                 730                 735     


Val Leu Lys Trp Thr Cys Pro Pro Gly Ala Asn Ala Gly Phe Glu Leu 
            740                 745                 750         


Glu Val Ser Ser Gly Ala Trp Asn Asn Ala Thr His Leu Glu Ser Cys 
        755                 760                 765             


Ser Ser Glu Asn Gly Thr Glu Tyr Arg Thr Glu Val Thr Tyr Leu Asn 
    770                 775                 780                 


Phe Ser Thr Ser Tyr Asn Ile Ser Ile Thr Thr Val Ser Cys Gly Lys 
785                 790                 795                 800 


Met Ala Ala Pro Thr Arg Asn Thr Cys Thr Thr Gly Ile Thr Asp Pro 
                805                 810                 815     


Pro Pro Pro Asp Gly Ser Pro Asn Ile Thr Ser Val Ser His Asn Ser 
            820                 825                 830         


Val Lys Val Lys Phe Ser Gly Phe Glu Ala Ser His Gly Pro Ile Lys 
        835                 840                 845             


Ala Tyr Ala Val Ile Leu Thr Thr Gly Glu Ala Gly His Pro Ser Ala 
    850                 855                 860                 


Asp Val Leu Lys Tyr Thr Tyr Glu Asp Phe Lys Lys Gly Ala Ser Asp 
865                 870                 875                 880 


Thr Tyr Val Thr Tyr Leu Ile Arg Thr Glu Glu Lys Gly Arg Ser Gln 
                885                 890                 895     


Ser Leu Ser Glu Val Leu Lys Tyr Glu Ile Asp Val Gly Asn Glu Ser 
            900                 905                 910         


Thr Thr Leu Gly Tyr Tyr Asn Gly Lys Leu Glu Pro Leu Gly Ser Tyr 
        915                 920                 925             


Arg Ala Cys Val Ala Gly Phe Thr Asn Ile Thr Phe His Pro Gln Asn 
    930                 935                 940                 


Lys Gly Leu Ile Asp Gly Ala Glu Ser Tyr Val Ser Phe Ser Arg Tyr 
945                 950                 955                 960 


Ser Asp Ala Val Ser Leu Pro Gln Asp Pro Gly Val Ile Cys Gly Ala 
                965                 970                 975     


Val Phe Gly Cys Ile Phe Gly Ala Leu Val Ile Val Thr Val Gly Gly 
            980                 985                 990         


Phe Ile Phe Trp Arg Lys Lys Arg  Lys Asp Ala Lys Asn  Asn Glu Val 
        995                 1000                 1005             


Ser Phe  Ser Gln Ile Lys Pro  Lys Lys Ser Lys Leu  Ile Arg Val 
    1010                 1015                 1020             


Glu Asn  Phe Glu Ala Tyr Phe  Lys Lys Gln Gln Ala  Asp Ser Asn 
    1025                 1030                 1035             


Cys Gly  Phe Ala Glu Glu Tyr  Glu Asp Leu Lys Leu  Val Gly Ile 
    1040                 1045                 1050             


Ser Gln  Pro Lys Tyr Ala Ala  Glu Leu Ala Glu Asn  Arg Gly Lys 
    1055                 1060                 1065             


Asn Arg  Tyr Asn Asn Val Leu  Pro Tyr Asp Ile Ser  Arg Val Lys 
    1070                 1075                 1080             


Leu Ser  Val Gln Thr His Ser  Thr Asp Asp Tyr Ile  Asn Ala Asn 
    1085                 1090                 1095             


Tyr Met  Pro Gly Tyr His Ser  Lys Lys Asp Phe Ile  Ala Thr Gln 
    1100                 1105                 1110             


Gly Pro  Leu Pro Asn Thr Leu  Lys Asp Phe Trp Arg  Met Val Trp 
    1115                 1120                 1125             


Glu Lys  Asn Val Tyr Ala Ile  Ile Met Leu Thr Lys  Cys Val Glu 
    1130                 1135                 1140             


Gln Gly  Arg Thr Lys Cys Glu  Glu Tyr Trp Pro Ser  Lys Gln Ala 
    1145                 1150                 1155             


Gln Asp  Tyr Gly Asp Ile Thr  Val Ala Met Thr Ser  Glu Ile Val 
    1160                 1165                 1170             


Leu Pro  Glu Trp Thr Ile Arg  Asp Phe Thr Val Lys  Asn Ile Gln 
    1175                 1180                 1185             


Thr Ser  Glu Ser His Pro Leu  Arg Gln Phe His Phe  Thr Ser Trp 
    1190                 1195                 1200             


Pro Asp  His Gly Val Pro Asp  Thr Thr Asp Leu Leu  Ile Asn Phe 
    1205                 1210                 1215             


Arg Tyr  Leu Val Arg Asp Tyr  Met Lys Gln Ser Pro  Pro Glu Ser 
    1220                 1225                 1230             


Pro Ile  Leu Val His Cys Ser  Ala Gly Val Gly Arg  Thr Gly Thr 
    1235                 1240                 1245             


Phe Ile  Ala Ile Asp Arg Leu  Ile Tyr Gln Ile Glu  Asn Glu Asn 
    1250                 1255                 1260             


Thr Val  Asp Val Tyr Gly Ile  Val Tyr Asp Leu Arg  Met His Arg 
    1265                 1270                 1275             


Pro Leu  Met Val Gln Thr Glu  Asp Gln Tyr Val Phe  Leu Asn Gln 
    1280                 1285                 1290             


Cys Val  Leu Asp Ile Val Arg  Ser Gln Lys Asp Ser  Lys Val Asp 
    1295                 1300                 1305             


Leu Ile  Tyr Gln Asn Thr Thr  Ala Met Thr Ile Tyr  Glu Asn Leu 
    1310                 1315                 1320             


Ala Pro  Val Thr Thr Phe Gly  Lys Thr Asn Gly Tyr  Ile Ala 
    1325                 1330                 1335         


<210>  2
<211>  940
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Gly Gly Thr Pro Ser Pro Ile Pro Asp Pro Ser Val Ala Thr Val 
1               5                   10                  15      


Ala Thr Gly Glu Asn Gly Ile Thr Gln Ile Ser Ser Thr Ala Glu Ser 
            20                  25                  30          


Phe His Lys Gln Asn Gly Thr Gly Thr Pro Gln Val Glu Thr Asn Thr 
        35                  40                  45              


Ser Glu Asp Gly Glu Ser Ser Gly Ala Asn Asp Ser Leu Arg Thr Pro 
    50                  55                  60                  


Glu Gln Gly Ser Asn Gly Thr Asp Gly Ala Ser Gln Lys Thr Pro Ser 
65                  70                  75                  80  


Ser Thr Gly Pro Ser Pro Val Phe Asp Ile Lys Ala Val Ser Ile Ser 
                85                  90                  95      


Pro Thr Asn Val Ile Leu Thr Trp Lys Ser Asn Asp Thr Ala Ala Ser 
            100                 105                 110         


Glu Tyr Lys Tyr Val Val Lys His Lys Met Glu Asn Glu Lys Thr Ile 
        115                 120                 125             


Thr Val Val His Gln Pro Trp Cys Asn Ile Thr Gly Leu Arg Pro Ala 
    130                 135                 140                 


Thr Ser Tyr Val Phe Ser Ile Thr Pro Gly Ile Gly Asn Glu Thr Trp 
145                 150                 155                 160 


Gly Asp Pro Arg Val Ile Lys Val Ile Thr Glu Pro Ile Pro Val Ser 
                165                 170                 175     


Asp Leu Arg Val Ala Leu Thr Gly Val Arg Lys Ala Ala Leu Ser Trp 
            180                 185                 190         


Ser Asn Gly Asn Gly Thr Ala Ser Cys Arg Val Leu Leu Glu Ser Ile 
        195                 200                 205             


Gly Ser His Glu Glu Leu Thr Gln Asp Ser Arg Leu Gln Val Asn Ile 
    210                 215                 220                 


Ser Gly Leu Lys Pro Gly Val Gln Tyr Asn Ile Asn Pro Tyr Leu Leu 
225                 230                 235                 240 


Gln Ser Asn Lys Thr Lys Gly Asp Pro Leu Gly Thr Glu Gly Gly Leu 
                245                 250                 255     


Asp Ala Ser Asn Thr Glu Arg Ser Arg Ala Gly Ser Pro Thr Ala Pro 
            260                 265                 270         


Val His Asp Glu Ser Leu Val Gly Pro Val Asp Pro Ser Ser Gly Gln 
        275                 280                 285             


Gln Ser Arg Asp Thr Glu Val Leu Leu Val Gly Leu Glu Pro Gly Thr 
    290                 295                 300                 


Arg Tyr Asn Ala Thr Val Tyr Ser Gln Ala Ala Asn Gly Thr Glu Gly 
305                 310                 315                 320 


Gln Pro Gln Ala Ile Glu Phe Arg Thr Asn Ala Ile Gln Val Phe Asp 
                325                 330                 335     


Val Thr Ala Val Asn Ile Ser Ala Thr Ser Leu Thr Leu Ile Trp Lys 
            340                 345                 350         


Val Ser Asp Asn Glu Ser Ser Ser Asn Tyr Thr Tyr Lys Ile His Val 
        355                 360                 365             


Ala Gly Glu Thr Asp Ser Ser Asn Leu Asn Val Ser Glu Pro Arg Ala 
    370                 375                 380                 


Val Ile Pro Gly Leu Arg Ser Ser Thr Phe Tyr Asn Ile Thr Val Cys 
385                 390                 395                 400 


Pro Val Leu Gly Asp Ile Glu Gly Thr Pro Gly Phe Leu Gln Val His 
                405                 410                 415     


Thr Pro Pro Val Pro Val Ser Asp Phe Arg Val Thr Val Val Ser Thr 
            420                 425                 430         


Thr Glu Ile Gly Leu Ala Trp Ser Ser His Asp Ala Glu Ser Phe Gln 
        435                 440                 445             


Met His Ile Thr Gln Glu Gly Ala Gly Asn Ser Arg Val Glu Ile Thr 
    450                 455                 460                 


Thr Asn Gln Ser Ile Ile Ile Gly Gly Leu Phe Pro Gly Thr Lys Tyr 
465                 470                 475                 480 


Cys Phe Glu Ile Val Pro Lys Gly Pro Asn Gly Thr Glu Gly Ala Ser 
                485                 490                 495     


Arg Thr Val Cys Asn Arg Thr Val Pro Ser Ala Val Phe Asp Ile His 
            500                 505                 510         


Val Val Tyr Val Thr Thr Thr Glu Met Trp Leu Asp Trp Lys Ser Pro 
        515                 520                 525             


Asp Gly Ala Ser Glu Tyr Val Tyr His Leu Val Ile Glu Ser Lys His 
    530                 535                 540                 


Gly Ser Asn His Thr Ser Thr Tyr Asp Lys Ala Ile Thr Leu Gln Gly 
545                 550                 555                 560 


Leu Ile Pro Gly Thr Leu Tyr Asn Ile Thr Ile Ser Pro Glu Val Asp 
                565                 570                 575     


His Val Trp Gly Asp Pro Asn Ser Thr Ala Gln Tyr Thr Arg Pro Ser 
            580                 585                 590         


Asn Val Ser Asn Ile Asp Val Ser Thr Asn Thr Thr Ala Ala Thr Leu 
        595                 600                 605             


Ser Trp Gln Asn Phe Asp Asp Ala Ser Pro Thr Tyr Ser Tyr Cys Leu 
    610                 615                 620                 


Leu Ile Glu Lys Ala Gly Asn Ser Ser Asn Ala Thr Gln Val Val Thr 
625                 630                 635                 640 


Asp Ile Gly Ile Thr Asp Ala Thr Val Thr Glu Leu Ile Pro Gly Ser 
                645                 650                 655     


Ser Tyr Thr Val Glu Ile Phe Ala Gln Val Gly Asp Gly Ile Lys Ser 
            660                 665                 670         


Leu Glu Pro Gly Arg Lys Ser Phe Cys Thr Asp Pro Ala Ser Met Ala 
        675                 680                 685             


Ser Phe Asp Cys Glu Val Val Pro Lys Glu Pro Ala Leu Val Leu Lys 
    690                 695                 700                 


Trp Thr Cys Pro Pro Gly Ala Asn Ala Gly Phe Glu Leu Glu Val Ser 
705                 710                 715                 720 


Ser Gly Ala Trp Asn Asn Ala Thr His Leu Glu Ser Cys Ser Ser Glu 
                725                 730                 735     


Asn Gly Thr Glu Tyr Arg Thr Glu Val Thr Tyr Leu Asn Phe Ser Thr 
            740                 745                 750         


Ser Tyr Asn Ile Ser Ile Thr Thr Val Ser Cys Gly Lys Met Ala Ala 
        755                 760                 765             


Pro Thr Arg Asn Thr Cys Thr Thr Gly Ile Thr Asp Pro Pro Pro Pro 
    770                 775                 780                 


Asp Gly Ser Pro Asn Ile Thr Ser Val Ser His Asn Ser Val Lys Val 
785                 790                 795                 800 


Lys Phe Ser Gly Phe Glu Ala Ser His Gly Pro Ile Lys Ala Tyr Ala 
                805                 810                 815     


Val Ile Leu Thr Thr Gly Glu Ala Gly His Pro Ser Ala Asp Val Leu 
            820                 825                 830         


Lys Tyr Thr Tyr Glu Asp Phe Lys Lys Gly Ala Ser Asp Thr Tyr Val 
        835                 840                 845             


Thr Tyr Leu Ile Arg Thr Glu Glu Lys Gly Arg Ser Gln Ser Leu Ser 
    850                 855                 860                 


Glu Val Leu Lys Tyr Glu Ile Asp Val Gly Asn Glu Ser Thr Thr Leu 
865                 870                 875                 880 


Gly Tyr Tyr Asn Gly Lys Leu Glu Pro Leu Gly Ser Tyr Arg Ala Cys 
                885                 890                 895     


Val Ala Gly Phe Thr Asn Ile Thr Phe His Pro Gln Asn Lys Gly Leu 
            900                 905                 910         


Ile Asp Gly Ala Glu Ser Tyr Val Ser Phe Ser Arg Tyr Ser Asp Ala 
        915                 920                 925             


Val Ser Leu Pro Gln Asp Pro Gly Val Ile Cys Gly 
    930                 935                 940 


<210>  3
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30          


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45              


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60                  


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95      


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110         


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125             


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140                 


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160 


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175     


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190         


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205             


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220                 


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240 


Thr Glu Ala 
            


<210>  4
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ser Gly Thr Glu 
1               5       


<210>  5
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Ala Asp Ala Ala Ala Gly Ala Pro Leu Pro Arg Leu Cys Cys 
1               5                   10                  15      


Leu Glu Lys Gly Pro Asn Gly Tyr Gly Phe His Leu His Gly Glu Lys 
            20                  25                  30          


Gly Lys Leu Gly Gln Tyr Ile Arg Leu Val Glu Pro Gly Ser Pro Ala 
        35                  40                  45              


Glu Lys Ala Gly Leu Leu Ala Gly Asp Arg Leu Val Glu Val Asn Gly 
    50                  55                  60                  


Glu Asn Val Glu Lys Glu Thr His Gln Gln Val Val Ser Arg Ile Arg 
65                  70                  75                  80  


Ala Ala Leu Asn Ala Val Arg Leu Leu Val Val Asp Pro Glu Thr Asp 
                85                  90                  95      


Glu Gln Leu Gln Lys Leu Gly Val Gln Val Arg Glu Glu Leu Leu Arg 
            100                 105                 110         


Ala Gln Glu Ala Pro Gly Gln Ala Glu Pro Pro Ala Ala Ala Glu Val 
        115                 120                 125             


Gln Gly Ala Gly Asn Glu Asn Glu Pro Arg Glu Ala Asp Lys Ser His 
    130                 135                 140                 


Pro Glu Gln Arg Glu Leu Arg Pro Arg Leu Cys Thr Met Lys Lys Gly 
145                 150                 155                 160 


Pro Ser Gly Tyr Gly Phe Asn Leu His Ser Asp Lys Ser Lys Pro Gly 
                165                 170                 175     


Gln Phe Ile Arg Ser Val Asp Pro Asp Ser Pro Ala Glu Ala Ser Gly 
            180                 185                 190         


Leu Arg Ala Gln Asp Arg Ile Val Glu Val Asn Gly Val Cys Met Glu 
        195                 200                 205             


Gly Lys Gln His Gly Asp Val Val Ser Ala Ile Arg Ala Gly Gly Asp 
    210                 215                 220                 


Glu Thr Lys Leu Leu Val Val Asp Arg Glu Thr Asp Glu Phe Phe Lys 
225                 230                 235                 240 


Lys Cys Arg Val Ile Pro Ser Gln Glu His Leu Asn Gly Pro Leu Pro 
                245                 250                 255     


Val Pro Phe Thr Asn Gly Glu Ile Gln Lys Glu Asn Ser Arg Glu Ala 
            260                 265                 270         


Leu Ala Glu Ala Ala Leu Glu Ser Pro Arg Pro Ala Leu Val Arg Ser 
        275                 280                 285             


Ala Ser Ser Asp Thr Ser Glu Glu Leu Asn Ser Gln Asp Ser Pro Pro 
    290                 295                 300                 


Lys Gln Asp Ser Thr Ala Pro Ser Ser Thr Ser Ser Ser Asp Pro Ile 
305                 310                 315                 320 


Leu Asp Phe Asn Ile Ser Leu Ala Met Ala Lys Glu Arg Ala His Gln 
                325                 330                 335     


Lys Arg Ser Ser Lys Arg Ala Pro Gln Met Asp Trp Ser Lys Lys Asn 
            340                 345                 350         


Glu Leu Phe Ser Asn Leu 
        355             


<210>  6
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Asp Arg Thr His Glu Leu Arg Gln Gly Asp Asp Ser Ser Asp 
1               5                   10                  15      


Glu Glu Asp Lys Glu Arg Val Ala Leu Val Val His Pro Gly Thr Ala 
            20                  25                  30          


Arg Leu Gly Ser Pro Asp Glu Glu Phe Phe His Lys Val Arg Thr Ile 
        35                  40                  45              


Arg Gln Thr Ile Val Lys Leu Gly Asn Lys Val Gln Glu Leu Glu Lys 
    50                  55                  60                  


Gln Gln Val Thr Ile Leu Ala Thr Pro Leu Pro Glu Glu Ser Met Lys 
65                  70                  75                  80  


Gln Glu Leu Gln Asn Leu Arg Asp Glu Ile Lys Gln Leu Gly Arg Glu 
                85                  90                  95      


Ile Arg Leu Gln Leu Lys Ala Ile Glu Pro Gln Lys Glu Glu Ala Asp 
            100                 105                 110         


Glu Asn Tyr Asn Ser Val Asn Thr Arg Met Arg Lys Thr Gln His Gly 
        115                 120                 125             


Val Leu Ser Gln Gln Phe Val Glu Leu Ile Asn Lys Cys Asn Ser Met 
    130                 135                 140                 


Gln Ser Glu Tyr Arg Glu Lys Asn Val Glu Arg Ile Arg Arg Gln Leu 
145                 150                 155                 160 


Lys Ile Thr Asn Ala Gly Met Val Ser Asp Glu Glu Leu Glu Gln Met 
                165                 170                 175     


Leu Asp Ser Gly Gln Ser Glu Val Phe Val Ser Asn Ile Leu Lys Asp 
            180                 185                 190         


Thr Gln Val Thr Arg Gln Ala Leu Asn Glu Ile Ser Ala Arg His Ser 
        195                 200                 205             


Glu Ile Gln Gln Leu Glu Arg Ser Ile Arg Glu Leu His Asp Ile Phe 
    210                 215                 220                 


Thr Phe Leu Ala Thr Glu Val Glu Met Gln Gly Glu Met Ile Asn Arg 
225                 230                 235                 240 


Ile Glu Lys Asn Ile Leu Ser Ser Ala Asp Tyr Val Glu Arg Gly Gln 
                245                 250                 255     


Glu His Val Lys Thr Ala Leu Glu Asn Gln Lys Lys Ala Arg Lys Lys 
            260                 265                 270         


Lys Val Leu Ile Ala Ile Cys Val Ser Ile Thr Val Val Leu Leu Ala 
        275                 280                 285             


Val Ile Ile Gly Val Thr Val Val Gly 
    290                 295         


<210>  7
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Thr Gly Pro Thr Ala Ala Thr Gly Ser Asn Arg Arg Leu Gln 
1               5                   10                  15      


Gln Thr Gln Asn Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn 
            20                  25                  30          


Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
        35                  40                  45              


Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala 
    50                  55                  60                  


Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys Met Trp Ala 
65                  70                  75                  80  


Ile Gly Ile Thr Val Leu Val Ile Phe Ile Ile Ile Ile Ile Val Trp 
                85                  90                  95      


Val Val Ser Ser 
            100 


<210>  8
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Tyr Ala Arg Lys Val Gly Trp Val Thr Ala Gly Leu Val Ile 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Lys 
            20                  25                  30          


Gln Asn Lys Glu Lys Met Ala Glu Gly Gly Ser Gly Asp Val Asp Asp 
        35                  40                  45              


Ala Gly Asp Cys Ser Gly Ala Arg Tyr Asn Asp Trp Ser Asp Asp Asp 
    50                  55                  60                  


Asp Asp Ser Asn Glu Ser Lys Ser Ile Val Trp Tyr Pro Pro Trp Ala 
65                  70                  75                  80  


Arg Ile Gly Thr Glu Ala Gly Thr Arg Ala Arg Ala Arg Ala Arg Ala 
                85                  90                  95      


Arg Ala Thr Arg Ala Arg Arg Ala Val Gln Lys Arg Ala Ser Pro Asn 
            100                 105                 110         


Ser Asp Asp Thr Val Leu Ser Pro Gln Glu Leu Gln Lys Val Leu Cys 
        115                 120                 125             


Leu Val Glu Met Ser Glu Lys Pro Tyr Ile Leu Glu Ala Ala Leu Ile 
    130                 135                 140                 


Ala Leu Gly Asn Asn Ala Ala Tyr Ala Phe Asn Arg Asp Ile Ile Arg 
145                 150                 155                 160 


Asp Leu Gly Gly Leu Pro Ile Val Ala Lys Ile Leu Asn Thr Arg Asp 
                165                 170                 175     


Pro Ile Val Lys Glu Lys Ala Leu Ile Val Leu Asn Asn Leu Ser Val 
            180                 185                 190         


Asn Ala Glu Asn Gln Arg Arg Leu Lys Val Tyr Met Asn Gln Val Cys 
        195                 200                 205             


Asp Asp Thr Ile Thr Ser Arg Leu Asn Ser Ser Val Gln Leu Ala Gly 
    210                 215                 220                 


Leu Arg Leu Leu Thr Asn Met Thr Val Thr Asn Glu Tyr Gln His Met 
225                 230                 235                 240 


Leu Ala Asn Ser Ile Ser Asp Phe Phe Arg Leu Phe Ser Ala Gly Asn 
                245                 250                 255     


Glu Glu Thr Lys Leu Gln Val Leu Lys Leu Leu Leu Asn Leu Ala Glu 
            260                 265                 270         


Asn Pro Ala Met Thr Arg Glu Leu Leu Arg Ala Gln Val Pro Ser Ser 
        275                 280                 285             


Leu Gly Ser Leu Phe Asn Lys Lys Glu Asn Lys Glu Val Ile Leu Lys 
    290                 295                 300                 


Leu Leu Val Ile Phe Glu Asn Ile Asn Asp Asn Phe Lys Trp Glu Glu 
305                 310                 315                 320 


Asn Glu Pro Thr Gln Asn Gln Phe Gly Glu Gly Ser Leu Phe Phe Phe 
                325                 330                 335     


Leu Lys Glu Phe Gln Val Cys Ala Asp Lys Val Leu Gly Ile Glu Ser 
            340                 345                 350         


His His Asp Phe Leu Val Lys Val Lys Val Gly Lys Phe Met Ala Lys 
        355                 360                 365             


Leu Ala Glu His Met Phe Pro Lys Ser Gln Glu 
    370                 375                 


<210>  9
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Tyr Ala Arg Lys 
1               5       


<210>  10
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  10

Asn Arg Asp Ile Ile Arg Asp Leu Gly Gly Leu Pro Ile Val Ala Lys 
1               5                   10                  15      


Ile Leu Asn Thr Arg Asp Pro Ile Val Lys Glu Lys Ala Leu Ile Val 
            20                  25                  30          


Leu Asn Asn Leu Ser Val Asn Ala Glu Asn Gln Arg Arg Leu Lys Val 
        35                  40                  45              


Tyr Met Asn Gln Val Cys Asp Asp Thr Ile Thr Ser Arg Leu Asn Ser 
    50                  55                  60                  


Ser Val Gln Leu Ala Gly Leu Arg Leu Leu Thr Asn Met Thr Val Thr 
65                  70                  75                  80  


Asn Glu Tyr Gln His Met Leu Ala Asn Ser Ile Ser Asp Phe Phe Arg 
                85                  90                  95      


Leu Phe Ser Ala Gly Asn Glu Glu Thr Lys Leu Gln Val Leu Lys Leu 
            100                 105                 110         


Leu Leu Asn Leu Ala Glu Asn Pro Ala Met Thr Arg Glu Leu Leu Arg 
        115                 120                 125             


Ala Gln Val Pro Ser Ser Leu Gly Ser Leu Phe Asn Lys Lys Glu Asn 
    130                 135                 140                 


Lys Glu Val Ile Leu Lys Leu Leu Val Ile Phe Glu Asn Ile Asn Asp 
145                 150                 155                 160 


Asn Phe Lys Trp Glu Glu Asn Glu Pro Thr Gln Asn Gln Phe Gly Glu 
                165                 170                 175     


Gly Ser Leu Phe Phe Phe Leu Lys Glu Phe Gln Val Cys Ala Asp Lys 
            180                 185                 190         


Val Leu Gly Ile Glu Ser His His Asp Phe Leu Val Lys Val Lys Val 
        195                 200                 205             


Gly Lys Phe Met Ala Lys Leu Ala Glu His Met Phe Pro Lys Ser Gln 
    210                 215                 220                 


Glu 
225 


<210>  11
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Gln Arg Ala Phe Pro Asn Pro Tyr Ala Asp Tyr Asn Lys Ser 
1               5                   10                  15      


Leu Ala Glu Gly Tyr Phe Asp Ala Ala Gly Arg Leu Thr Pro Glu Phe 
            20                  25                  30          


Ser Gln Arg Leu Thr Asn Lys Ile Arg Glu Leu Leu Gln Gln Met Glu 
        35                  40                  45              


Arg Gly Leu Lys Ser Ala Asp Pro Arg Asp Gly Thr Gly Tyr Thr Gly 
    50                  55                  60                  


Trp Ala Gly Ile Ala Val Leu Tyr Leu His Leu Tyr Asp Val Phe Gly 
65                  70                  75                  80  


Asp Pro Ala Tyr Leu Gln Leu Ala His Gly Tyr Val Lys Gln Ser Leu 
                85                  90                  95      


Asn Cys Leu Thr Lys Arg Ser Ile Thr Phe Leu Cys Gly Asp Ala Gly 
            100                 105                 110         


Pro Leu Ala Val Ala Ala Val Leu Tyr His Lys Met Asn Asn Glu Lys 
        115                 120                 125             


Gln Ala Glu Asp Cys Ile Thr Arg Leu Ile His Leu Asn Lys Ile Asp 
    130                 135                 140                 


Pro His Ala Pro Asn Glu Met Leu Tyr Gly Arg Ile Gly Tyr Ile Tyr 
145                 150                 155                 160 


Ala Leu Leu Phe Val Asn Lys Asn Phe Gly Val Glu Lys Ile Pro Gln 
                165                 170                 175     


Ser His Ile Gln Gln Ile Cys Glu Thr Ile Leu Thr Ser Gly Glu Asn 
            180                 185                 190         


Leu Ala Arg Lys Arg Asn Phe Thr Ala Lys Ser Pro Leu Met Tyr Glu 
        195                 200                 205             


Trp Tyr Gln Glu Tyr Tyr Val Gly Ala Ala His Gly Leu Ala Gly Ile 
    210                 215                 220                 


Tyr Tyr Tyr Leu Met Gln Pro Ser Leu Gln Val Ser Gln Gly Lys Leu 
225                 230                 235                 240 


His Ser Leu Val Lys Pro Ser Val Asp Tyr Val Cys Gln Leu Lys Phe 
                245                 250                 255     


Pro Ser Gly Asn Tyr Pro Pro Cys Ile Gly Asp Asn Arg Asp Leu Leu 
            260                 265                 270         


Val His Trp Cys His Gly Ala Pro Gly Val Ile Tyr Met Leu Ile Gln 
        275                 280                 285             


Ala Tyr Lys Val Phe Arg Glu Glu Lys Tyr Leu Cys Asp Ala Tyr Gln 
    290                 295                 300                 


Cys Ala Asp Val Ile Trp Gln Tyr Gly Leu Leu Lys Lys Gly Tyr Gly 
305                 310                 315                 320 


Leu Cys His Gly Ser Ala Gly Asn Ala Tyr Ala Phe Leu Thr Leu Tyr 
                325                 330                 335     


Asn Leu Thr Gln Asp Met Lys Tyr Leu Tyr Arg Ala Cys Lys Phe Ala 
            340                 345                 350         


Glu Trp Cys Leu Glu Tyr Gly Glu His Gly Cys Arg Thr Pro Asp Thr 
        355                 360                 365             


Pro Phe Ser Leu Phe Glu Gly Met Ala Gly Thr Ile Tyr Phe Leu Ala 
    370                 375                 380                 


Asp Leu Leu Val Pro Thr Lys Ala Arg Phe Pro Ala Phe Glu Leu 
385                 390                 395                 


<210>  12
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Val Phe Gly Asp Pro Ala Tyr Leu Gln Leu Ala His Gly Tyr Val 
1               5                   10                  15      


Lys Gln Ser Leu Asn Cys Leu Thr Lys Arg 
            20                  25      


<210>  13
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Lys Ile Pro Gln Ser His Ile Gln Gln Ile Cys Glu Thr Ile Leu 
1               5                   10                  15      


Thr Ser Gly Glu Asn Leu Ala Arg Lys Arg Asn Phe Thr Ala Lys Ser 
            20                  25                  30          


Pro Leu Met Tyr Glu Trp Tyr Gln Glu Tyr Tyr Val Gly Ala Ala His 
        35                  40                  45              


Gly Leu Ala Gly Ile Tyr Tyr Tyr Leu Met Gln Pro Ser Leu Gln Val 
    50                  55                  60                  


Ser Gln Gly Lys Leu His Ser Leu Val Lys Pro Ser Val Asp Tyr Val 
65                  70                  75                  80  


Cys Gln Leu Lys Phe Pro Ser Gly Asn Tyr Pro Pro Cys Ile Gly Asp 
                85                  90                  95      


Asn Arg Asp 
            


<210>  14
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Met Lys Tyr Leu Tyr Arg Ala Cys Lys Phe Ala Glu Trp Cys Leu 
1               5                   10                  15      


Glu Tyr Gly Glu His Gly Cys Arg Thr Pro Asp Thr Pro 
            20                  25                  


<210>  15
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  16
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  17
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Lys Pro Lys Leu Met Tyr Gln Glu Leu Lys Val Pro Ala Glu Glu 
1               5                   10                  15      


Pro Ala Asn Glu Leu Pro Met Asn Glu Ile Glu Ala Trp Lys Ala Ala 
            20                  25                  30          


Glu Lys Lys Ala Arg Trp Val Leu Leu Val Leu Ile Leu Ala Val Val 
        35                  40                  45              


Gly Phe Gly Ala Leu Met Thr Gln Leu Phe Leu Trp Glu Tyr Gly Asp 
    50                  55                  60                  


Leu His Leu Phe Gly Pro Asn Gln Arg Pro Ala Pro Cys Tyr Asp Pro 
65                  70                  75                  80  


Cys Glu Ala Val Leu Val Glu Ser Ile Pro Glu Gly Leu Asp Phe Pro 
                85                  90                  95      


Asn Ala Ser Thr Gly Asn Pro Ser Thr Ser Gln Ala Trp Leu Gly Leu 
            100                 105                 110         


Leu Ala Gly Ala His Ser Ser Leu Asp Ile Ala Ser Phe Tyr Trp Thr 
        115                 120                 125             


Leu Thr Asn Asn Asp Thr His Thr Gln Glu Pro Ser Ala Gln Gln Gly 
    130                 135                 140                 


Glu Glu Val Leu Arg Gln Leu Gln Thr Leu Ala Pro Lys Gly Val Asn 
145                 150                 155                 160 


Val Arg Ile Ala Val Ser Lys Pro Ser Gly Pro Gln Pro Gln Ala Asp 
                165                 170                 175     


Leu Gln Ala Leu Leu Gln Ser Gly Ala Gln Val Arg Met Val Asp Met 
            180                 185                 190         


Gln Lys Leu Thr His Gly Val Leu His Thr Lys Phe Trp Val Val Asp 
        195                 200                 205             


Gln Thr His Phe Tyr Leu Gly Ser Ala Asn Met Asp Trp Arg Ser Leu 
    210                 215                 220                 


Thr Gln Val Lys Glu Leu Gly Val Val Met Tyr Asn Cys Ser Cys Leu 
225                 230                 235                 240 


Ala Arg Asp Leu Thr Lys Ile Phe Glu Ala Tyr Trp Phe Leu Gly Gln 
                245                 250                 255     


Ala Gly Ser Ser Ile Pro Ser Thr Trp Pro Arg Phe Tyr Asp Thr Arg 
            260                 265                 270         


Tyr Asn Gln Glu Thr Pro Met Glu Ile Cys Leu Asn Gly Thr Pro Ala 
        275                 280                 285             


Leu Ala Tyr Leu Ala Ser Ala Pro Pro Pro Leu Cys Pro Ser Gly Arg 
    290                 295                 300                 


Thr Pro Asp Leu Lys Ala Leu Leu Asn Val Val Asp Asn Ala Arg Ser 
305                 310                 315                 320 


Phe Ile Tyr Val Ala Val Met Asn Tyr Leu Pro Thr Leu Glu Phe Ser 
                325                 330                 335     


His Pro His Arg Phe Trp Pro Ala Ile Asp Asp Gly Leu Arg Arg Ala 
            340                 345                 350         


Thr Tyr Glu Arg Gly Val Lys Val Arg Leu Leu Ile Ser Cys Trp Gly 
        355                 360                 365             


His Ser Glu Pro Ser Met Arg Ala Phe Leu Leu Ser Leu Ala Ala Leu 
    370                 375                 380                 


Arg Asp Asn His Thr His Ser Asp Ile Gln Val Lys Leu Phe Val Val 
385                 390                 395                 400 


Pro Ala Asp Glu Ala Gln Ala Arg Ile Pro Tyr Ala Arg Val Asn His 
                405                 410                 415     


Asn Lys Tyr Met Val Thr Glu Arg Ala Thr Tyr Ile Gly Thr Ser Asn 
            420                 425                 430         


Trp Ser Gly Asn Tyr Phe Thr Glu Thr Ala Gly Thr Ser Leu Leu Val 
        435                 440                 445             


Thr Gln Asn Gly Arg Gly Gly Leu Arg Ser Gln Leu Glu Ala Ile Phe 
    450                 455                 460                 


Leu Arg Asp Trp Asp Ser Pro Tyr Ser His Asp Leu Asp Thr Ser Ala 
465                 470                 475                 480 


Asp Ser Val Gly Asn Ala Cys Arg Leu Leu 
                485                 490 


<210>  18
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Leu Phe Leu Trp Glu Tyr Gly Asp Leu His Leu Phe Gly Pro Asn 
1               5                   10                  15      


Gln Arg Pro Ala Pro Cys Tyr Asp Pro Cys Glu Ala Val Leu Val Glu 
            20                  25                  30          


Ser Ile Pro Glu Gly Leu Asp Phe Pro Asn Ala Ser Thr Gly Asn Pro 
        35                  40                  45              


Ser Thr Ser Gln Ala Trp Leu Gly Leu Leu Ala Gly Ala His Ser Ser 
    50                  55                  60                  


Leu Asp Ile Ala Ser Phe Tyr Trp Thr Leu Thr Asn Asn Asp Thr His 
65                  70                  75                  80  


Thr Gln Glu Pro Ser Ala Gln Gln Gly Glu Glu Val Leu Arg Gln Leu 
                85                  90                  95      


Gln Thr Leu Ala Pro Lys Gly Val Asn Val Arg Ile Ala Val Ser Lys 
            100                 105                 110         


Pro Ser Gly Pro Gln Pro Gln Ala Asp Leu Gln Ala Leu Leu Gln Ser 
        115                 120                 125             


Gly Ala Gln Val Arg Met Val Asp Met Gln Lys Leu Thr His Gly Val 
    130                 135                 140                 


Leu Ser His Thr Lys Phe Trp Val Val Asp Gln Thr His Phe Tyr Leu 
145                 150                 155                 160 


Gly Ser Ala Asn Met Asp Trp Arg Ser Leu Thr Gln Val Lys Glu Leu 
                165                 170                 175     


Gly Val Val Met Tyr Asn Cys Ser Cys Leu Ala Arg Asp Leu Thr Lys 
            180                 185                 190         


Ile Phe Glu Ala Tyr Trp Phe Leu Gly Gln Ala Gly Ser Ser Ile Pro 
        195                 200                 205             


Ser Thr Trp Pro Arg Phe Tyr Asp Thr Arg Tyr Asn Gln Glu Thr Pro 
    210                 215                 220                 


Met Glu Ile Cys Leu Asn Gly Thr Pro Ala Leu Ala Tyr Leu Ala Ser 
225                 230                 235                 240 


Ala Pro Pro Pro Leu Cys Pro Ser Gly Arg Thr Pro Asp Leu Lys Ala 
                245                 250                 255     


Leu Leu Asn Val Val Asp Asn Ala Arg Ser Phe Ile Tyr Val Ala Val 
            260                 265                 270         


Met Asn Tyr Leu Pro Thr Leu Glu Phe Ser His Pro His Arg Phe Trp 
        275                 280                 285             


Pro Ala Ile Asp Asp Gly Leu Arg Arg Ala Thr Tyr Glu Arg Gly Val 
    290                 295                 300                 


Lys Val Arg Leu Leu Ile Ser Cys Trp Gly His Ser Glu Pro Ser Met 
305                 310                 315                 320 


Arg Ala Phe Leu Leu Ser Leu Ala Ala Leu Arg Asp Asn His Thr His 
                325                 330                 335     


Ser Asp Ile Gln Val Lys Leu Phe Val Val Pro Ala Asp Glu Ala Gln 
            340                 345                 350         


Ala Arg Ile Pro Tyr Ala Arg Val Asn His Asn Lys Tyr Met Val Thr 
        355                 360                 365             


Glu Arg Ala Thr Tyr Ile Gly Thr Ser Asn Trp Ser Gly Asn Tyr Phe 
    370                 375                 380                 


Thr Glu Thr Ala Gly Thr Ser Leu Leu Val Thr Gln Asn Gly Arg Gly 
385                 390                 395                 400 


Gly Leu Arg Ser Gln Leu Glu Ala Ile Phe Leu Arg Asp Trp Asp Ser 
                405                 410                 415     


Pro Tyr Ser His Asp Leu Asp Thr Ser Ala Asp Ser Val Gly Asn Ala 
            420                 425                 430         


Cys Arg Leu Leu 
        435     


<210>  19
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ser Phe Leu Gly Gly Phe Phe Gly Pro Ile Cys Glu Ile Asp Ile 
1               5                   10                  15      


Val Leu Asn Asp Gly Glu Thr Arg Lys Met Ala Glu Met Lys Thr Glu 
            20                  25                  30          


Asp Gly Lys Val Glu Lys His Tyr Leu Phe Tyr Asp Gly Glu Ser Val 
        35                  40                  45              


Ser Gly Lys Val Asn Leu Ala Phe Lys Gln Pro Gly Lys Arg Leu Glu 
    50                  55                  60                  


His Gln Gly Ile Arg Ile Glu Phe Val Gly Gln Ile Glu Leu Phe Asn 
65                  70                  75                  80  


Asp Lys Ser Asn Thr His Glu Phe Val Asn Leu Val Lys Glu Leu Ala 
                85                  90                  95      


Leu Pro Gly Glu Leu Thr Gln Ser Arg Ser Tyr Asp Phe Glu Phe Met 
            100                 105                 110         


Gln Val Glu Lys Pro Tyr Glu Ser Tyr Ile Gly Ala Asn Val Arg Leu 
        115                 120                 125             


Arg Tyr Phe Leu Lys Val Thr Ile Val Arg Arg Leu Thr Asp Leu Val 
    130                 135                 140                 


Lys Glu Tyr Asp Leu Ile Val His Gln Leu Ala Thr Tyr Pro Asp Val 
145                 150                 155                 160 


Asn Asn Ser Ile Lys Met Glu Val Gly Ile Glu Asp Cys Leu His Ile 
                165                 170                 175     


Glu Phe Glu Tyr Asn Lys Ser Lys Tyr His Leu Lys Asp Val Ile Val 
            180                 185                 190         


Gly Lys Ile Tyr Phe Leu Leu Val Arg Ile Lys Ile Gln His Met Glu 
        195                 200                 205             


Leu Gln Leu Ile Lys Lys Glu Ile Thr Gly Ile Gly Pro Ser Thr Thr 
    210                 215                 220                 


Thr Glu Thr Glu Thr Ile Ala Lys Tyr Glu Ile Met Asp Gly Ala Pro 
225                 230                 235                 240 


Val Lys Gly Glu Ser Ile Pro Ile Arg Leu Phe Leu Ala Gly Tyr Asp 
                245                 250                 255     


Pro Thr Pro Thr Met Arg Asp Val Asn Lys Lys Phe Ser Val Arg Tyr 
            260                 265                 270         


Phe Leu Asn Leu Val Leu Val Asp Glu Glu Asp Arg Arg Tyr Phe Lys 
        275                 280                 285             


Gln Gln Glu Ile Ile Leu Trp Arg Lys Ala Pro Glu Lys Leu Arg Lys 
    290                 295                 300                 


Gln Arg Thr Asn Phe His Gln Arg Phe Glu Ser Pro Glu Ser Gln Ala 
305                 310                 315                 320 


Ser Ala Glu Gln Pro Glu Met 
                325         


