                               SEQUENCE LISTING

<110> ZYMEWORKS INC.
 
<120> MODIFIED ANTIGEN BINDING POLYPEPTIDE CONSTRUCTS AND USES THEREOF

<130> 97993-945204 (000110PC)

<140>
<141>

<150> 62/154,055
<151> 2015-04-28

<150> 62/003,663
<151> 2014-05-28

<160> 12    

<170> PatentIn version 3.5

<210> 1
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 2
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 3
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 4
<211> 446
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Glu Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Leu Ile Asp Pro Glu Gln Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Ile Ser Ala Asp Asn Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Ala Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210> 5
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210> 6
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210> 7
<211> 1347
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
gaggtgcagc tggtggaaag cggaggagga ctggtgcagc caggaggatc tctgcgactg       60

agttgcgccg cttcaggatt caacatcaag gacacctaca ttcactgggt gcgacaggct      120

ccaggaaaag gactggagtg ggtggctcga atctatccca ctaatggata cacccggtat      180

gccgactccg tgaaggggag gtttactatt agcgccgata catccaaaaa cactgcttac      240

ctgcagatga acagcctgcg agccgaagat accgctgtgt actattgcag tcgatgggga      300

ggagacggat tctacgctat ggattattgg ggacagggga ccctggtgac agtgagctcc      360

gcctctacca agggccccag tgtgtttccc ctggctcctt ctagtaaatc cacctctgga      420

gggacagccg ctctgggatg tctggtgaag gactatttcc ccgagcctgt gaccgtgagt      480

tggaactcag gcgccctgac aagcggagtg cacacttttc ctgctgtgct gcagtcaagc      540

gggctgtact ccctgtcctc tgtggtgaca gtgccaagtt caagcctggg cacacagact      600

tatatctgca acgtgaatca taagccctca aatacaaaag tggacaagaa agtggagccc      660

aagagctgtg ataagaccca cacctgccct ccctgtccag ctccagaact gctgggagga      720

cctagcgtgt tcctgtttcc ccctaagcca aaagacactc tgatgatttc caggactccc      780

gaggtgacct gcgtggtggt ggacgtgtct cacgaggacc ccgaagtgaa gttcaactgg      840

tacgtggatg gcgtggaagt gcataatgct aagacaaaac caagagagga acagtacaac      900

tccacttatc gcgtcgtgag cgtgctgacc gtgctgcacc aggactggct gaacgggaag      960

gagtataagt gcaaagtcag taataaggcc ctgcctgctc caatcgaaaa aaccatctct     1020

aaggccaaag gccagccaag ggagccccag gtgtacacac tgccacccag cagagacgaa     1080

ctgaccaaga accaggtgtc cctgacatgt ctggtgaaag gcttctatcc tagtgatatt     1140

gctgtggagt gggaatcaaa tggacagcca gagaacaatt acaagaccac acctccagtg     1200

ctggacagcg atggcagctt cttcctgtat tccaagctga cagtggataa atctcgatgg     1260

cagcagggga acgtgtttag ttgttcagtg atgcatgaag ccctgcacaa tcattacact     1320

cagaagagcc tgtccctgtc tcccggc                                         1347


<210> 8
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca ggacgttaac accgctgtag cttggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctattct gcatcctttt tgtacagtgg ggtcccatca      180

aggttcagtg gcagtcgatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag cattacacta ccccacccac tttcggccaa      300

gggaccaaag tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccaa      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210> 9
<211> 1344
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
caggtgcagc tgaaacagag cggcccgggc ctggtgcagc cgagccagag cctgagcatt       60

acctgcaccg tgagcggctt tagcctgacc aactatggcg tgcattgggt gcgccagagc      120

ccgggcaaag gcctggaatg gctgggcgtg atttggagcg gcggcaacac cgattataac      180

accccgttta ccagccgcct gagcattaac aaagataaca gcaaaagcca ggtgtttttt      240

aaaatgaaca gcctgcagag caacgatacc gcgatttatt attgcgcgcg cgcgctgacc      300

tattatgatt atgaatttgc gtattggggc cagggcaccc tggtgaccgt gagcgcggcg      360

agcaccaaag gcccgagcgt gtttccgctg gcgccgagca gcaaaagcac cagcggcggc      420

accgcggcgc tgggctgcct ggtgaaagat tattttccgg aaccggtgac cgtgagctgg      480

aacagcggcg cgctgaccag cggcgtgcat acctttccgg cggtgctgca gagcagcggc      540

ctgtatagcc tgagcagcgt ggtgaccgtg ccgagcagca gcctgggcac ccagacctat      600

atttgcaacg tgaaccataa accgagcaac accaaagtgg ataaaaaagt ggaaccgaaa      660

agctgcgata aaacccatac ctgcccgccg tgcccggcgc cggaactgct gggcggcccg      720

agcgtgtttc tgtttccgcc gaaaccgaaa gataccctga tgattagccg caccccggaa      780

gtgacctgcg tggtggtgga tgtgagccat gaagatccgg aagtgaaatt taactggtat      840

gtggatggcg tggaagtgca taacgcgaaa accaaaccgc gcgaagaaca gtataacagc      900

acctatcgcg tggtgagcgt gctgaccgtg ctgcatcagg attggctgaa cggcaaagaa      960

tataaatgca aagtgagcaa caaagcgctg ccggcgccga ttgaaaaaac cattagcaaa     1020

gcgaaaggcc agccgcgcga accgcaggtg tataccctgc cgccgagccg cgatgaactg     1080

accaaaaacc aggtgagcct gacctgcctg gtgaaaggct tttatccgag cgatattgcg     1140

gtggaatggg aaagcaacgg ccagccggaa aacaactata aaaccacccc gccggtgctg     1200

gatagcgatg gcagcttttt tctgtatagc aaactgaccg tggataaaag ccgctggcag     1260

cagggcaacg tgtttagctg cagcgtgatg catgaagcgc tgcataacca ttatacccag     1320

aaaagcctga gcctgagccc gggc                                            1344


<210> 10
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
gacatcctgc tgactcagag cccagtgatc ctgtcagtca gcccaggaga gcgggtgtcc       60

ttctcttgca gagcaagtca gtcaatcgga acaaatattc actggtacca gcagaggact      120

aacggctccc ctcgcctgct gattaagtat gctagcgaat ccatctctgg cattccatct      180

cggttcagtg gctcagggag cggaacagac tttactctgt ccatcaattc tgtggagagt      240

gaagacattg ccgattacta ttgccagcag aacaataact ggcccaccac attcggcgct      300

gggaccaagc tggagctgaa acgaacagtg gccgctcctt ctgtcttcat ctttccccct      360

agtgacgaac agctgaaaag cggcacagcc tccgtggtct gtctgctgaa taacttttac      420

ccaagagagg caaaggtgca gtggaaagtc gataatgccc tgcagtcagg gaacagccag      480

gagtccgtga ctgaacagga ctctaaggat agtacctatt cactgagctc cactctgacc      540

ctgtccaaag ctgattacga gaagcacaaa gtgtatgcat gcgaagtcac ccatcagggg      600

ctgtctagtc ccgtgacaaa gagctttaac cggggagagt gt                         642


<210> 11
<211> 1338
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
gaggtgcagc tggtcgaatc tggaggagga ctggtgcagc caggagggtc actgagactg       60

agctgcgccg cttccggctt caacatcaag gagtactata tgcactgggt gaggcaggca      120

cctggcaaag gactggagtg ggtgggactg atcgacccag aacaggggaa caccatctac      180

gaccctaagt ttcaggatag ggcaaccatt tctgccgaca acagtaaaaa tacagcttat      240

ctgcagatga acagcctgag ggctgaagat actgcagtgt actattgcgc acgcgacacc      300

gcagcctact tcgattattg gggacagggc accctggtca cagtgagctc cgcatcaact      360

aagggaccca gcgtgtttcc actggccccc tctagtaaat ccacttctgg aggcaccgct      420

gcactgggct gtctggtgaa ggattacttc ccagagcccg tcacagtgag ctggaactcc      480

ggggccctga ccagcggagt ccatacattt cctgctgtgc tgcagtcaag cgggctgtac      540

tccctgtcct ctgtggtcac cgtgccaagt tcaagcctgg gaactcagac ctatatctgc      600

aacgtgaatc acaagccttc aaatacaaaa gtcgacaaga aagtggaacc aaagagctgt      660

gataaaacac atacttgccc accttgtcct gcaccagagc tgctgggagg accaagcgtg      720

ttcctgtttc cacccaagcc caaagacacc ctgatgattt cccgcacacc agaagtcact      780

tgcgtggtcg tggacgtgtc tcacgaggac cccgaagtca agttcaactg gtacgtggat      840

ggcgtcgagg tgcataatgc caagacaaaa ccccgggagg aacagtacaa ctccacatat      900

agagtcgtgt ctgtcctgac tgtgctgcac caggactggc tgaacgggaa ggagtataag      960

tgcaaagtga gtaataaggc cctgcccgct cctatcgaga aaacaattag caaggccaaa     1020

ggccagcctc gagaaccaca ggtgtacact ctgcctccat ctcgggacga gctgactaag     1080

aaccaggtca gtctgacctg tctggtgaaa ggattctatc ccagcgatat cgctgtggag     1140

tgggaatcca atggccagcc tgagaacaat tacaagacca caccccctgt gctggactct     1200

gatggcagtt tctttctgta tagtaagctg accgtcgata aatcacgatg gcagcagggg     1260

aacgtgttca gctgttcagt gatgcacgaa gccctgcaca accattacac ccagaagagc     1320

ctgagcctgt ctcccggc                                                   1338


<210> 12
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
gacatccaga tgacacagtc ccctagctcc ctgagtgcct cagtggggga cagagtcact       60

atcacctgcc gggcttccag agatattaag tcttacctga actggtatca gcagaagcca      120

ggcaaagcac ccaaggtgct gatctactat gccaccagtc tggctgaagg agtgccttca      180

cggttcagcg gctccgggtc tggaactgac tacacactga ctatttctag tctgcagcct      240

gaggatttcg ctacctacta ttgcctgcag cacggcgaat ccccatggac ttttggccag      300

gggaccaaag tggagatcaa gaggacagtg gccgctccat ccgtcttcat ttttccccct      360

tctgacgaac agctgaaatc aggaactgcc agcgtggtct gtctgctgaa caatttctac      420

ccccgcgagg caaaagtgca gtggaaggtc gataacgccc tgcagagtgg caattcacag      480

gagagcgtga cagaacagga ctccaaagat tctacttata gtctgtcaag caccctgaca      540

ctgtctaagg ctgattacga gaagcacaaa gtgtatgcat gcgaagtcac ccatcagggg      600

ctgtcctctc ccgtgacaaa gagctttaat cggggagagt gt                         642


