                         SEQUENCE LISTING

<110>  E.I. duPont de Nemours and Company, Inc.
       DiCosimo, Robert
       Ouwehand, Arthur
       Eliot, Andrew
       You, Zheng
       Cheng, Qiong
       Payne, Mark
 
<120>  ENZYMATIC SYNTHESIS OF SOLUBLE GLUCAN FIBER

<130>  CL6238PCT

<150>  62/004312

<151>  2014-05-29

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1146
<212>  PRT
<213>  Paenibacillus humicus

<400>  1

Met Arg Ile Arg Thr Lys Tyr Met Asn Trp Met Leu Val Leu Val Leu 
1               5                   10                  15      


Ile Ala Ala Gly Phe Phe Gln Ala Ala Gly Pro Ile Ala Pro Ala Thr 
            20                  25                  30          


Ala Ala Gly Gly Ala Asn Leu Thr Leu Gly Lys Thr Val Thr Ala Ser 
        35                  40                  45              


Gly Gln Ser Gln Thr Tyr Ser Pro Asp Asn Val Lys Asp Ser Asn Gln 
    50                  55                  60                  


Gly Thr Tyr Trp Glu Ser Thr Asn Asn Ala Phe Pro Gln Trp Ile Gln 
65                  70                  75                  80  


Val Asp Leu Gly Ala Ser Thr Ser Ile Asp Gln Ile Val Leu Lys Leu 
                85                  90                  95      


Pro Ser Gly Trp Glu Thr Arg Thr Gln Thr Leu Ser Ile Gln Gly Ser 
            100                 105                 110         


Ala Asn Gly Ser Thr Phe Thr Asn Ile Val Gly Ser Ala Gly Tyr Thr 
        115                 120                 125             


Phe Asn Pro Ser Val Ala Gly Asn Ser Val Thr Ile Asn Phe Ser Ala 
    130                 135                 140                 


Ala Ser Ala Arg Tyr Val Arg Leu Asn Phe Thr Ala Asn Thr Gly Trp 
145                 150                 155                 160 


Pro Ala Gly Gln Leu Ser Glu Leu Glu Ile Tyr Gly Ala Thr Ala Pro 
                165                 170                 175     


Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro 
            180                 185                 190         


Thr Pro Thr Pro Thr Val Thr Pro Ala Pro Ser Ala Thr Pro Thr Pro 
        195                 200                 205             


Thr Pro Pro Ala Gly Ser Asn Ile Ala Val Gly Lys Ser Ile Thr Ala 
    210                 215                 220                 


Ser Ser Ser Thr Gln Thr Tyr Val Ala Ala Asn Ala Asn Asp Asn Asn 
225                 230                 235                 240 


Thr Ser Thr Tyr Trp Glu Gly Gly Ser Asn Pro Ser Thr Leu Thr Leu 
                245                 250                 255     


Asp Phe Gly Ser Asn Gln Ser Ile Thr Ser Val Val Leu Lys Leu Asn 
            260                 265                 270         


Pro Ala Ser Glu Trp Gly Thr Arg Thr Gln Thr Ile Gln Val Leu Gly 
        275                 280                 285             


Ala Asp Gln Asn Ala Gly Ser Phe Ser Asn Leu Val Ser Ala Gln Ser 
    290                 295                 300                 


Tyr Thr Phe Asn Pro Ala Thr Gly Asn Thr Val Thr Ile Pro Val Ser 
305                 310                 315                 320 


Ala Thr Val Lys Arg Leu Gln Leu Asn Ile Thr Ala Asn Ser Gly Ala 
                325                 330                 335     


Pro Ala Gly Gln Ile Ala Glu Phe Gln Val Phe Gly Thr Pro Ala Pro 
            340                 345                 350         


Asn Pro Asp Leu Thr Ile Thr Gly Met Ser Trp Thr Pro Ser Ser Pro 
        355                 360                 365             


Val Glu Ser Gly Asp Ile Thr Leu Asn Ala Val Val Lys Asn Ile Gly 
    370                 375                 380                 


Thr Ala Ala Ala Gly Ala Thr Thr Val Asn Phe Tyr Leu Asn Asn Glu 
385                 390                 395                 400 


Leu Ala Gly Thr Ala Pro Val Gly Ala Leu Ala Ala Gly Ala Ser Ala 
                405                 410                 415     


Asn Val Ser Ile Asn Ala Gly Ala Lys Ala Ala Ala Thr Tyr Ala Val 
            420                 425                 430         


Ser Ala Lys Val Asp Glu Ser Asn Ala Val Ile Glu Gln Asn Glu Gly 
        435                 440                 445             


Asn Asn Ser Tyr Ser Asn Pro Thr Asn Leu Val Val Ala Pro Val Ser 
    450                 455                 460                 


Ser Ser Asp Leu Val Ala Val Thr Ser Trp Ser Pro Gly Thr Pro Ser 
465                 470                 475                 480 


Gln Gly Ala Ala Val Ala Phe Thr Val Ala Leu Lys Asn Gln Gly Thr 
                485                 490                 495     


Leu Ala Ser Ala Gly Gly Ala His Pro Val Thr Val Val Leu Lys Asn 
            500                 505                 510         


Ala Ala Gly Ala Thr Leu Gln Thr Phe Thr Gly Thr Tyr Thr Gly Ser 
        515                 520                 525             


Leu Ala Ala Gly Ala Ser Ala Asn Ile Ser Val Gly Ser Trp Thr Ala 
    530                 535                 540                 


Ala Ser Gly Thr Tyr Thr Val Ser Thr Thr Val Ala Ala Asp Gly Asn 
545                 550                 555                 560 


Glu Ile Pro Ala Lys Gln Ser Asn Asn Thr Ser Ser Ala Ser Leu Thr 
                565                 570                 575     


Val Tyr Ser Ala Arg Gly Ala Ser Met Pro Tyr Ser Arg Tyr Asp Thr 
            580                 585                 590         


Glu Asp Ala Val Leu Gly Gly Gly Ala Val Leu Arg Thr Ala Pro Thr 
        595                 600                 605             


Phe Asp Gln Ser Leu Ile Ala Ser Glu Ala Ser Gly Gln Lys Tyr Ala 
    610                 615                 620                 


Ala Leu Pro Ser Asn Gly Ser Ser Leu Gln Trp Thr Val Arg Gln Gly 
625                 630                 635                 640 


Gln Gly Gly Ala Gly Val Thr Met Arg Phe Thr Met Pro Asp Thr Ser 
                645                 650                 655     


Asp Gly Met Gly Gln Asn Gly Ser Leu Asp Val Tyr Val Asn Gly Thr 
            660                 665                 670         


Lys Ala Lys Thr Val Ser Leu Thr Ser Tyr Tyr Ser Trp Gln Tyr Phe 
        675                 680                 685             


Ser Gly Asp Met Pro Ala Asp Ala Pro Gly Gly Gly Arg Pro Leu Phe 
    690                 695                 700                 


Arg Phe Asp Glu Val His Phe Lys Leu Asp Thr Ala Leu Lys Pro Gly 
705                 710                 715                 720 


Asp Thr Ile Arg Val Gln Lys Gly Gly Asp Ser Leu Glu Tyr Gly Val 
                725                 730                 735     


Asp Phe Ile Glu Ile Glu Pro Ile Pro Ala Ala Val Ala Arg Pro Ala 
            740                 745                 750         


Asn Ser Val Ser Val Thr Glu Tyr Gly Ala Val Ala Asn Asp Gly Lys 
        755                 760                 765             


Asp Asp Leu Ala Ala Phe Lys Ala Ala Val Thr Ala Ala Val Ala Ala 
    770                 775                 780                 


Gly Lys Ser Leu Tyr Ile Pro Glu Gly Thr Phe His Leu Ser Ser Met 
785                 790                 795                 800 


Trp Glu Ile Gly Ser Ala Thr Ser Met Ile Asp Asn Phe Thr Val Thr 
                805                 810                 815     


Gly Ala Gly Ile Trp Tyr Thr Asn Ile Gln Phe Thr Asn Pro Asn Ala 
            820                 825                 830         


Ser Gly Gly Gly Ile Ser Leu Arg Ile Lys Gly Lys Leu Asp Phe Ser 
        835                 840                 845             


Asn Ile Tyr Met Asn Ser Asn Leu Arg Ser Arg Tyr Gly Gln Asn Ala 
    850                 855                 860                 


Val Tyr Lys Gly Phe Met Asp Asn Phe Gly Thr Asn Ser Ile Ile His 
865                 870                 875                 880 


Asp Val Trp Val Glu His Phe Glu Cys Gly Met Trp Val Gly Asp Tyr 
                885                 890                 895     


Ala His Thr Pro Ala Ile Tyr Ala Ser Gly Leu Val Val Glu Asn Ser 
            900                 905                 910         


Arg Ile Arg Asn Asn Leu Ala Asp Gly Ile Asn Phe Ser Gln Gly Thr 
        915                 920                 925             


Ser Asn Ser Thr Val Arg Asn Ser Ser Ile Arg Asn Asn Gly Asp Asp 
    930                 935                 940                 


Gly Leu Ala Val Trp Thr Ser Asn Thr Asn Gly Ala Pro Ala Gly Val 
945                 950                 955                 960 


Asn Asn Thr Phe Ser Tyr Asn Thr Ile Glu Asn Asn Trp Arg Ala Ala 
                965                 970                 975     


Ala Ile Ala Phe Phe Gly Gly Ser Gly His Lys Ala Asp His Asn Tyr 
            980                 985                 990         


Ile Ile Asp Cys Val Gly Gly Ser  Gly Ile Arg Met Asn  Thr Val Phe 
        995                 1000                 1005             


Pro Gly  Tyr His Phe Gln Asn  Asn Thr Gly Ile Thr  Phe Ser Asp 
    1010                 1015                 1020             


Thr Thr  Ile Ile Asn Ser Gly  Thr Ser Gln Asp Leu  Tyr Asn Gly 
    1025                 1030                 1035             


Glu Arg  Gly Ala Ile Asp Leu  Glu Ala Ser Asn Asp  Ala Ile Lys 
    1040                 1045                 1050             


Asn Val  Thr Phe Thr Asn Ile  Asp Ile Ile Asn Ala  Gln Arg Asp 
    1055                 1060                 1065             


Gly Val  Gln Ile Gly Tyr Gly  Gly Gly Phe Glu Asn  Ile Val Phe 
    1070                 1075                 1080             


Asn Asn  Ile Thr Ile Asp Gly  Thr Gly Arg Asp Gly  Ile Ser Thr 
    1085                 1090                 1095             


Ser Arg  Phe Ser Gly Pro His  Leu Gly Ala Ala Ile  Tyr Thr Tyr 
    1100                 1105                 1110             


Thr Gly  Asn Gly Ser Ala Thr  Phe Asn Asn Leu Val  Thr Arg Asn 
    1115                 1120                 1125             


Ile Ala  Tyr Ala Gly Gly Asn  Tyr Ile Gln Ser Gly  Phe Asn Leu 
    1130                 1135                 1140             


Thr Ile  Lys 
    1145     


<210>  2
<211>  3351
<212>  DNA
<213>  Paenibacillus humicus

<400>  2
atggctagcg cagcaggagg cgcgaatctg acgctcggca aaaccgtcac cgccagcggc       60

cagtcgcaga cgtacagccc cgacaatgtc aaggacagca atcagggaac ttactgggaa      120

agcacgaaca acgccttccc gcagtggatc caagtcgacc ttggcgccag cacgagcatc      180

gaccagatcg tgctcaaact tccgtccgga tgggagactc gtacgcaaac gctctcgata      240

cagggcagcg cgaacggctc gacgttcacg aacatcgtcg gatcggccgg gtatacattc      300

aatccatccg tcgccggcaa cagcgtcacg atcaacttca gcgctgccag cgcccgctac      360

gtccgcctga atttcacggc caatacgggc tggccagcag gccagctgtc ggagcttgag      420

atctacggag cgacggcgcc aacgcctact cccacgccta ctccaacacc aacgccaacg      480

ccaacaccaa cgccaacccc tacagtaacc cctgcgcctt cggccacgcc gactccgact      540

cctccggcag gcagcaacat cgccgtaggg aaatcgatta cagcctcttc cagcacgcag      600

acctacgtag ctgcaaatgc aaatgacaac aatacatcca cctattggga gggaggaagc      660

aacccgagca cgctgactct cgatttcggt tccaaccaga gcatcacttc cgtcgtcctc      720

aagctgaatc cggcttcgga atgggggact cgcacgcaaa cgatccaagt tcttggagcg      780

gatcagaacg ccggctcctt cagcaatctc gtctctgccc agtcctatac gttcaatccc      840

gcaaccggca atacggtgac gattccggtc tccgcgacgg tcaagcgcct ccagctgaac      900

attacggcga actccggcgc ccctgccggc cagattgccg agttccaagt gttcggcacg      960

ccagcgccta atccggactt gaccattacc ggcatgtcct ggactccgtc ttctccggtc     1020

gagagcggcg acattacgct gaacgccgtc gtcaagaaca tcggaactgc agctgcaggc     1080

gccacgacgg tcaatttcta cctgaacaac gaactcgccg gcaccgctcc ggtaggcgcg     1140

cttgcggcag gagcttctgc aaatgtatcg atcaatgcag gcgccaaagc agccgcaacg     1200

tatgcggtaa gcgccaaagt cgacgagagc aacgccgtca tcgagcagaa tgaaggcaac     1260

aacagctact cgaacccgac taacctcgtc gtagcgccgg tgtccagctc cgacctcgtc     1320

gccgtgacgt catggtcgcc gggcacgccg tcgcagggag cggcggtcgc atttaccgtc     1380

gcgcttaaaa atcagggtac gctggcttcc gccggcggag cccatcccgt aaccgtcgtt     1440

ctgaaaaacg ctgccggagc gacgctgcaa accttcacgg gcacctacac aggttccctg     1500

gcagcaggcg catccgcgaa tatcagcgtg ggcagctgga cggcagcgag cggcacctat     1560

accgtctcga cgacggtagc cgctgacggc aatgaaattc cggccaagca aagcaacaat     1620

acgagcagcg cgagcctcac ggtctactcg gcgcgcggcg ccagcatgcc gtacagccgt     1680

tacgacacgg aggatgcggt gctcggcggc ggagctgtcc tgagaacggc gccgacgttc     1740

gatcagtcgc tcatcgcttc cgaagcatcg ggacagaaat acgccgcact tccgtccaac     1800

ggctccagcc tgcagtggac cgtccgtcaa ggccagggcg gtgcaggcgt cacgatgcgc     1860

ttcacgatgc ccgacacgag cgacggcatg ggccagaacg gctcgctcga cgtctatgtc     1920

aacggaacca aagccaaaac ggtgtcgctg acctcttatt acagctggca gtatttctcc     1980

ggcgacatgc cggctgacgc tccgggcggc ggcaggccgc tcttccgctt cgacgaagtc     2040

cacttcaagc tggatacggc gttgaagccg ggagacacga tccgcgtcca gaagggcggt     2100

gacagcctgg agtacggcgt cgacttcatc gagatcgagc cgattccggc agcggttgcc     2160

cgtccggcca actcggtgtc cgtcaccgaa tacggcgctg tcgccaatga cggcaaggat     2220

gatctcgccg ccttcaaggc tgccgtgacc gcagcggtag cggccggaaa atccctctac     2280

atcccggaag gcaccttcca cctgagcagc atgtgggaga tcggctcggc caccagcatg     2340

atcgacaact tcacggtcac gggtgccggc atctggtata cgaacatcca gttcacgaat     2400

cccaatgcat cgggcggcgg catctccctg agaatcaaag gaaagctgga tttcagcaac     2460

atctacatga actccaacct gcgttcccgt tacgggcaga acgccgtcta caaaggcttt     2520

atggacaatt tcggcactaa ttcgatcatc catgacgtct gggtcgagca tttcgaatgc     2580

ggcatgtggg tcggcgacta cgcccatact cctgcgatct atgcgagcgg gctcgtcgtg     2640

gaaaacagcc gcatccgcaa caatcttgcc gacggcatca acttctcgca gggaacgagc     2700

aactcgaccg tccgcaacag cagcatccgc aacaacggcg atgacggcct cgccgtctgg     2760

acgagcaaca cgaacggcgc tccggccggc gtgaacaaca ccttctccta caacacgatc     2820

gagaacaact ggcgcgcggc ggccatcgcc ttcttcggcg gcagcggcca caaggctgac     2880

cacaactaca tcatcgactg tgtcggcggc tccggcatcc ggatgaatac ggtgttccca     2940

ggctaccact tccagaacaa caccggcatc accttctcgg atacgacgat catcaacagc     3000

ggcaccagcc aggatctgta caacggcgag cgcggagcga ttgatctgga agcatccaac     3060

gacgcgatca aaaacgtcac cttcaccaac atcgacatca tcaatgccca gcgcgacggc     3120

gttcagatcg gctatggcgg cggcttcgag aacatcgtgt tcaacaacat cacgatcgac     3180

ggcaccggcc gcgacgggat atcgacatcc cgcttctcgg gacctcatct tggcgcagcc     3240

atctatacgt acacgggcaa cggctcggcg acgttcaaca acctggtgac ccggaacatc     3300

gcctatgcag gcggcaacta catccagagc gggttcaacc tgacgatcta a              3351


<210>  3
<211>  1116
<212>  PRT
<213>  Paenibacillus humicus

<400>  3

Met Ala Ser Ala Ala Gly Gly Ala Asn Leu Thr Leu Gly Lys Thr Val 
1               5                   10                  15      


Thr Ala Ser Gly Gln Ser Gln Thr Tyr Ser Pro Asp Asn Val Lys Asp 
            20                  25                  30          


Ser Asn Gln Gly Thr Tyr Trp Glu Ser Thr Asn Asn Ala Phe Pro Gln 
        35                  40                  45              


Trp Ile Gln Val Asp Leu Gly Ala Ser Thr Ser Ile Asp Gln Ile Val 
    50                  55                  60                  


Leu Lys Leu Pro Ser Gly Trp Glu Thr Arg Thr Gln Thr Leu Ser Ile 
65                  70                  75                  80  


Gln Gly Ser Ala Asn Gly Ser Thr Phe Thr Asn Ile Val Gly Ser Ala 
                85                  90                  95      


Gly Tyr Thr Phe Asn Pro Ser Val Ala Gly Asn Ser Val Thr Ile Asn 
            100                 105                 110         


Phe Ser Ala Ala Ser Ala Arg Tyr Val Arg Leu Asn Phe Thr Ala Asn 
        115                 120                 125             


Thr Gly Trp Pro Ala Gly Gln Leu Ser Glu Leu Glu Ile Tyr Gly Ala 
    130                 135                 140                 


Thr Ala Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr 
145                 150                 155                 160 


Pro Thr Pro Thr Pro Thr Pro Thr Val Thr Pro Ala Pro Ser Ala Thr 
                165                 170                 175     


Pro Thr Pro Thr Pro Pro Ala Gly Ser Asn Ile Ala Val Gly Lys Ser 
            180                 185                 190         


Ile Thr Ala Ser Ser Ser Thr Gln Thr Tyr Val Ala Ala Asn Ala Asn 
        195                 200                 205             


Asp Asn Asn Thr Ser Thr Tyr Trp Glu Gly Gly Ser Asn Pro Ser Thr 
    210                 215                 220                 


Leu Thr Leu Asp Phe Gly Ser Asn Gln Ser Ile Thr Ser Val Val Leu 
225                 230                 235                 240 


Lys Leu Asn Pro Ala Ser Glu Trp Gly Thr Arg Thr Gln Thr Ile Gln 
                245                 250                 255     


Val Leu Gly Ala Asp Gln Asn Ala Gly Ser Phe Ser Asn Leu Val Ser 
            260                 265                 270         


Ala Gln Ser Tyr Thr Phe Asn Pro Ala Thr Gly Asn Thr Val Thr Ile 
        275                 280                 285             


Pro Val Ser Ala Thr Val Lys Arg Leu Gln Leu Asn Ile Thr Ala Asn 
    290                 295                 300                 


Ser Gly Ala Pro Ala Gly Gln Ile Ala Glu Phe Gln Val Phe Gly Thr 
305                 310                 315                 320 


Pro Ala Pro Asn Pro Asp Leu Thr Ile Thr Gly Met Ser Trp Thr Pro 
                325                 330                 335     


Ser Ser Pro Val Glu Ser Gly Asp Ile Thr Leu Asn Ala Val Val Lys 
            340                 345                 350         


Asn Ile Gly Thr Ala Ala Ala Gly Ala Thr Thr Val Asn Phe Tyr Leu 
        355                 360                 365             


Asn Asn Glu Leu Ala Gly Thr Ala Pro Val Gly Ala Leu Ala Ala Gly 
    370                 375                 380                 


Ala Ser Ala Asn Val Ser Ile Asn Ala Gly Ala Lys Ala Ala Ala Thr 
385                 390                 395                 400 


Tyr Ala Val Ser Ala Lys Val Asp Glu Ser Asn Ala Val Ile Glu Gln 
                405                 410                 415     


Asn Glu Gly Asn Asn Ser Tyr Ser Asn Pro Thr Asn Leu Val Val Ala 
            420                 425                 430         


Pro Val Ser Ser Ser Asp Leu Val Ala Val Thr Ser Trp Ser Pro Gly 
        435                 440                 445             


Thr Pro Ser Gln Gly Ala Ala Val Ala Phe Thr Val Ala Leu Lys Asn 
    450                 455                 460                 


Gln Gly Thr Leu Ala Ser Ala Gly Gly Ala His Pro Val Thr Val Val 
465                 470                 475                 480 


Leu Lys Asn Ala Ala Gly Ala Thr Leu Gln Thr Phe Thr Gly Thr Tyr 
                485                 490                 495     


Thr Gly Ser Leu Ala Ala Gly Ala Ser Ala Asn Ile Ser Val Gly Ser 
            500                 505                 510         


Trp Thr Ala Ala Ser Gly Thr Tyr Thr Val Ser Thr Thr Val Ala Ala 
        515                 520                 525             


Asp Gly Asn Glu Ile Pro Ala Lys Gln Ser Asn Asn Thr Ser Ser Ala 
    530                 535                 540                 


Ser Leu Thr Val Tyr Ser Ala Arg Gly Ala Ser Met Pro Tyr Ser Arg 
545                 550                 555                 560 


Tyr Asp Thr Glu Asp Ala Val Leu Gly Gly Gly Ala Val Leu Arg Thr 
                565                 570                 575     


Ala Pro Thr Phe Asp Gln Ser Leu Ile Ala Ser Glu Ala Ser Gly Gln 
            580                 585                 590         


Lys Tyr Ala Ala Leu Pro Ser Asn Gly Ser Ser Leu Gln Trp Thr Val 
        595                 600                 605             


Arg Gln Gly Gln Gly Gly Ala Gly Val Thr Met Arg Phe Thr Met Pro 
    610                 615                 620                 


Asp Thr Ser Asp Gly Met Gly Gln Asn Gly Ser Leu Asp Val Tyr Val 
625                 630                 635                 640 


Asn Gly Thr Lys Ala Lys Thr Val Ser Leu Thr Ser Tyr Tyr Ser Trp 
                645                 650                 655     


Gln Tyr Phe Ser Gly Asp Met Pro Ala Asp Ala Pro Gly Gly Gly Arg 
            660                 665                 670         


Pro Leu Phe Arg Phe Asp Glu Val His Phe Lys Leu Asp Thr Ala Leu 
        675                 680                 685             


Lys Pro Gly Asp Thr Ile Arg Val Gln Lys Gly Gly Asp Ser Leu Glu 
    690                 695                 700                 


Tyr Gly Val Asp Phe Ile Glu Ile Glu Pro Ile Pro Ala Ala Val Ala 
705                 710                 715                 720 


Arg Pro Ala Asn Ser Val Ser Val Thr Glu Tyr Gly Ala Val Ala Asn 
                725                 730                 735     


Asp Gly Lys Asp Asp Leu Ala Ala Phe Lys Ala Ala Val Thr Ala Ala 
            740                 745                 750         


Val Ala Ala Gly Lys Ser Leu Tyr Ile Pro Glu Gly Thr Phe His Leu 
        755                 760                 765             


Ser Ser Met Trp Glu Ile Gly Ser Ala Thr Ser Met Ile Asp Asn Phe 
    770                 775                 780                 


Thr Val Thr Gly Ala Gly Ile Trp Tyr Thr Asn Ile Gln Phe Thr Asn 
785                 790                 795                 800 


Pro Asn Ala Ser Gly Gly Gly Ile Ser Leu Arg Ile Lys Gly Lys Leu 
                805                 810                 815     


Asp Phe Ser Asn Ile Tyr Met Asn Ser Asn Leu Arg Ser Arg Tyr Gly 
            820                 825                 830         


Gln Asn Ala Val Tyr Lys Gly Phe Met Asp Asn Phe Gly Thr Asn Ser 
        835                 840                 845             


Ile Ile His Asp Val Trp Val Glu His Phe Glu Cys Gly Met Trp Val 
    850                 855                 860                 


Gly Asp Tyr Ala His Thr Pro Ala Ile Tyr Ala Ser Gly Leu Val Val 
865                 870                 875                 880 


Glu Asn Ser Arg Ile Arg Asn Asn Leu Ala Asp Gly Ile Asn Phe Ser 
                885                 890                 895     


Gln Gly Thr Ser Asn Ser Thr Val Arg Asn Ser Ser Ile Arg Asn Asn 
            900                 905                 910         


Gly Asp Asp Gly Leu Ala Val Trp Thr Ser Asn Thr Asn Gly Ala Pro 
        915                 920                 925             


Ala Gly Val Asn Asn Thr Phe Ser Tyr Asn Thr Ile Glu Asn Asn Trp 
    930                 935                 940                 


Arg Ala Ala Ala Ile Ala Phe Phe Gly Gly Ser Gly His Lys Ala Asp 
945                 950                 955                 960 


His Asn Tyr Ile Ile Asp Cys Val Gly Gly Ser Gly Ile Arg Met Asn 
                965                 970                 975     


Thr Val Phe Pro Gly Tyr His Phe Gln Asn Asn Thr Gly Ile Thr Phe 
            980                 985                 990         


Ser Asp Thr Thr Ile Ile Asn Ser  Gly Thr Ser Gln Asp  Leu Tyr Asn 
        995                 1000                 1005             


Gly Glu  Arg Gly Ala Ile Asp  Leu Glu Ala Ser Asn  Asp Ala Ile 
    1010                 1015                 1020             


Lys Asn  Val Thr Phe Thr Asn  Ile Asp Ile Ile Asn  Ala Gln Arg 
    1025                 1030                 1035             


Asp Gly  Val Gln Ile Gly Tyr  Gly Gly Gly Phe Glu  Asn Ile Val 
    1040                 1045                 1050             


Phe Asn  Asn Ile Thr Ile Asp  Gly Thr Gly Arg Asp  Gly Ile Ser 
    1055                 1060                 1065             


Thr Ser  Arg Phe Ser Gly Pro  His Leu Gly Ala Ala  Ile Tyr Thr 
    1070                 1075                 1080             


Tyr Thr  Gly Asn Gly Ser Ala  Thr Phe Asn Asn Leu  Val Thr Arg 
    1085                 1090                 1095             


Asn Ile  Ala Tyr Ala Gly Gly  Asn Tyr Ile Gln Ser  Gly Phe Asn 
    1100                 1105                 1110             


Leu Thr  Ile 
    1115     


<210>  4
<211>  26
<212>  PRT
<213>  Bacillus subtilis

<400>  4

Met Arg Ser Lys Lys Leu Trp Ile Ser Leu Leu Phe Ala Leu Thr Leu 
1               5                   10                  15      


Ile Phe Thr Met Ala Phe Ser Asn Met Ser 
            20                  25      


<210>  5
<211>  3426
<212>  DNA
<213>  Paenibacillus humicus

<400>  5
gtgagaagca aaaaattgtg gatcagcttg ttgtttgcgt taacgttaat ctttacgatg       60

gcgttcagca acatgtctgc tagcgcagca ggaggcgcga atctgacgct cggcaaaacc      120

gtcaccgcca gcggccagtc gcagacgtac agccccgaca atgtcaagga cagcaatcag      180

ggaacttact gggaaagcac gaacaacgcc ttcccgcagt ggatccaagt cgaccttggc      240

gccagcacga gcatcgacca gatcgtgctc aaacttccgt ccggatggga gactcgtacg      300

caaacgctct cgatacaggg cagcgcgaac ggctcgacgt tcacgaacat cgtcggatcg      360

gccgggtata cattcaatcc atccgtcgcc ggcaacagcg tcacgatcaa cttcagcgct      420

gccagcgccc gctacgtccg cctgaatttc acggccaata cgggctggcc agcaggccag      480

ctgtcggagc ttgagatcta cggagcgacg gcgccaacgc ctactcccac gcctactcca      540

acaccaacgc caacgccaac accaacgcca acccctacag taacccctgc gccttcggcc      600

acgccgactc cgactcctcc ggcaggcagc aacatcgccg tagggaaatc gattacagcc      660

tcttccagca cgcagaccta cgtagctgca aatgcaaatg acaacaatac atccacctat      720

tgggagggag gaagcaaccc gagcacgctg actctcgatt tcggttccaa ccagagcatc      780

acttccgtcg tcctcaagct gaatccggct tcggaatggg ggactcgcac gcaaacgatc      840

caagttcttg gagcggatca gaacgccggc tccttcagca atctcgtctc tgcccagtcc      900

tatacgttca atcccgcaac cggcaatacg gtgacgattc cggtctccgc gacggtcaag      960

cgcctccagc tgaacattac ggcgaactcc ggcgcccctg ccggccagat tgccgagttc     1020

caagtgttcg gcacgccagc gcctaatccg gacttgacca ttaccggcat gtcctggact     1080

ccgtcttctc cggtcgagag cggcgacatt acgctgaacg ccgtcgtcaa gaacatcgga     1140

actgcagctg caggcgccac gacggtcaat ttctacctga acaacgaact cgccggcacc     1200

gctccggtag gcgcgcttgc ggcaggagct tctgcaaatg tatcgatcaa tgcaggcgcc     1260

aaagcagccg caacgtatgc ggtaagcgcc aaagtcgacg agagcaacgc cgtcatcgag     1320

cagaatgaag gcaacaacag ctactcgaac ccgactaacc tcgtcgtagc gccggtgtcc     1380

agctccgacc tcgtcgccgt gacgtcatgg tcgccgggca cgccgtcgca gggagcggcg     1440

gtcgcattta ccgtcgcgct taaaaatcag ggtacgctgg cttccgccgg cggagcccat     1500

cccgtaaccg tcgttctgaa aaacgctgcc ggagcgacgc tgcaaacctt cacgggcacc     1560

tacacaggtt ccctggcagc aggcgcatcc gcgaatatca gcgtgggcag ctggacggca     1620

gcgagcggca cctataccgt ctcgacgacg gtagccgctg acggcaatga aattccggcc     1680

aagcaaagca acaatacgag cagcgcgagc ctcacggtct actcggcgcg cggcgccagc     1740

atgccgtaca gccgttacga cacggaggat gcggtgctcg gcggcggagc tgtcctgaga     1800

acggcgccga cgttcgatca gtcgctcatc gcttccgaag catcgggaca gaaatacgcc     1860

gcacttccgt ccaacggctc cagcctgcag tggaccgtcc gtcaaggcca gggcggtgca     1920

ggcgtcacga tgcgcttcac gatgcccgac acgagcgacg gcatgggcca gaacggctcg     1980

ctcgacgtct atgtcaacgg aaccaaagcc aaaacggtgt cgctgacctc ttattacagc     2040

tggcagtatt tctccggcga catgccggct gacgctccgg gcggcggcag gccgctcttc     2100

cgcttcgacg aagtccactt caagctggat acggcgttga agccgggaga cacgatccgc     2160

gtccagaagg gcggtgacag cctggagtac ggcgtcgact tcatcgagat cgagccgatt     2220

ccggcagcgg ttgcccgtcc ggccaactcg gtgtccgtca ccgaatacgg cgctgtcgcc     2280

aatgacggca aggatgatct cgccgccttc aaggctgccg tgaccgcagc ggtagcggcc     2340

ggaaaatccc tctacatccc ggaaggcacc ttccacctga gcagcatgtg ggagatcggc     2400

tcggccacca gcatgatcga caacttcacg gtcacgggtg ccggcatctg gtatacgaac     2460

atccagttca cgaatcccaa tgcatcgggc ggcggcatct ccctgagaat caaaggaaag     2520

ctggatttca gcaacatcta catgaactcc aacctgcgtt cccgttacgg gcagaacgcc     2580

gtctacaaag gctttatgga caatttcggc actaattcga tcatccatga cgtctgggtc     2640

gagcatttcg aatgcggcat gtgggtcggc gactacgccc atactcctgc gatctatgcg     2700

agcgggctcg tcgtggaaaa cagccgcatc cgcaacaatc ttgccgacgg catcaacttc     2760

tcgcagggaa cgagcaactc gaccgtccgc aacagcagca tccgcaacaa cggcgatgac     2820

ggcctcgccg tctggacgag caacacgaac ggcgctccgg ccggcgtgaa caacaccttc     2880

tcctacaaca cgatcgagaa caactggcgc gcggcggcca tcgccttctt cggcggcagc     2940

ggccacaagg ctgaccacaa ctacatcatc gactgtgtcg gcggctccgg catccggatg     3000

aatacggtgt tcccaggcta ccacttccag aacaacaccg gcatcacctt ctcggatacg     3060

acgatcatca acagcggcac cagccaggat ctgtacaacg gcgagcgcgg agcgattgat     3120

ctggaagcat ccaacgacgc gatcaaaaac gtcaccttca ccaacatcga catcatcaat     3180

gcccagcgcg acggcgttca gatcggctat ggcggcggct tcgagaacat cgtgttcaac     3240

aacatcacga tcgacggcac cggccgcgac gggatatcga catcccgctt ctcgggacct     3300

catcttggcg cagccatcta tacgtacacg ggcaacggct cggcgacgtt caacaacctg     3360

gtgacccgga acatcgccta tgcaggcggc aactacatcc agagcgggtt caacctgacg     3420

atctaa                                                                3426


<210>  6
<211>  1141
<212>  PRT
<213>  Paenibacillus humicus

<400>  6

Met Arg Ser Lys Lys Leu Trp Ile Ser Leu Leu Phe Ala Leu Thr Leu 
1               5                   10                  15      


Ile Phe Thr Met Ala Phe Ser Asn Met Ser Ala Ser Ala Ala Gly Gly 
            20                  25                  30          


Ala Asn Leu Thr Leu Gly Lys Thr Val Thr Ala Ser Gly Gln Ser Gln 
        35                  40                  45              


Thr Tyr Ser Pro Asp Asn Val Lys Asp Ser Asn Gln Gly Thr Tyr Trp 
    50                  55                  60                  


Glu Ser Thr Asn Asn Ala Phe Pro Gln Trp Ile Gln Val Asp Leu Gly 
65                  70                  75                  80  


Ala Ser Thr Ser Ile Asp Gln Ile Val Leu Lys Leu Pro Ser Gly Trp 
                85                  90                  95      


Glu Thr Arg Thr Gln Thr Leu Ser Ile Gln Gly Ser Ala Asn Gly Ser 
            100                 105                 110         


Thr Phe Thr Asn Ile Val Gly Ser Ala Gly Tyr Thr Phe Asn Pro Ser 
        115                 120                 125             


Val Ala Gly Asn Ser Val Thr Ile Asn Phe Ser Ala Ala Ser Ala Arg 
    130                 135                 140                 


Tyr Val Arg Leu Asn Phe Thr Ala Asn Thr Gly Trp Pro Ala Gly Gln 
145                 150                 155                 160 


Leu Ser Glu Leu Glu Ile Tyr Gly Ala Thr Ala Pro Thr Pro Thr Pro 
                165                 170                 175     


Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro 
            180                 185                 190         


Thr Val Thr Pro Ala Pro Ser Ala Thr Pro Thr Pro Thr Pro Pro Ala 
        195                 200                 205             


Gly Ser Asn Ile Ala Val Gly Lys Ser Ile Thr Ala Ser Ser Ser Thr 
    210                 215                 220                 


Gln Thr Tyr Val Ala Ala Asn Ala Asn Asp Asn Asn Thr Ser Thr Tyr 
225                 230                 235                 240 


Trp Glu Gly Gly Ser Asn Pro Ser Thr Leu Thr Leu Asp Phe Gly Ser 
                245                 250                 255     


Asn Gln Ser Ile Thr Ser Val Val Leu Lys Leu Asn Pro Ala Ser Glu 
            260                 265                 270         


Trp Gly Thr Arg Thr Gln Thr Ile Gln Val Leu Gly Ala Asp Gln Asn 
        275                 280                 285             


Ala Gly Ser Phe Ser Asn Leu Val Ser Ala Gln Ser Tyr Thr Phe Asn 
    290                 295                 300                 


Pro Ala Thr Gly Asn Thr Val Thr Ile Pro Val Ser Ala Thr Val Lys 
305                 310                 315                 320 


Arg Leu Gln Leu Asn Ile Thr Ala Asn Ser Gly Ala Pro Ala Gly Gln 
                325                 330                 335     


Ile Ala Glu Phe Gln Val Phe Gly Thr Pro Ala Pro Asn Pro Asp Leu 
            340                 345                 350         


Thr Ile Thr Gly Met Ser Trp Thr Pro Ser Ser Pro Val Glu Ser Gly 
        355                 360                 365             


Asp Ile Thr Leu Asn Ala Val Val Lys Asn Ile Gly Thr Ala Ala Ala 
    370                 375                 380                 


Gly Ala Thr Thr Val Asn Phe Tyr Leu Asn Asn Glu Leu Ala Gly Thr 
385                 390                 395                 400 


Ala Pro Val Gly Ala Leu Ala Ala Gly Ala Ser Ala Asn Val Ser Ile 
                405                 410                 415     


Asn Ala Gly Ala Lys Ala Ala Ala Thr Tyr Ala Val Ser Ala Lys Val 
            420                 425                 430         


Asp Glu Ser Asn Ala Val Ile Glu Gln Asn Glu Gly Asn Asn Ser Tyr 
        435                 440                 445             


Ser Asn Pro Thr Asn Leu Val Val Ala Pro Val Ser Ser Ser Asp Leu 
    450                 455                 460                 


Val Ala Val Thr Ser Trp Ser Pro Gly Thr Pro Ser Gln Gly Ala Ala 
465                 470                 475                 480 


Val Ala Phe Thr Val Ala Leu Lys Asn Gln Gly Thr Leu Ala Ser Ala 
                485                 490                 495     


Gly Gly Ala His Pro Val Thr Val Val Leu Lys Asn Ala Ala Gly Ala 
            500                 505                 510         


Thr Leu Gln Thr Phe Thr Gly Thr Tyr Thr Gly Ser Leu Ala Ala Gly 
        515                 520                 525             


Ala Ser Ala Asn Ile Ser Val Gly Ser Trp Thr Ala Ala Ser Gly Thr 
    530                 535                 540                 


Tyr Thr Val Ser Thr Thr Val Ala Ala Asp Gly Asn Glu Ile Pro Ala 
545                 550                 555                 560 


Lys Gln Ser Asn Asn Thr Ser Ser Ala Ser Leu Thr Val Tyr Ser Ala 
                565                 570                 575     


Arg Gly Ala Ser Met Pro Tyr Ser Arg Tyr Asp Thr Glu Asp Ala Val 
            580                 585                 590         


Leu Gly Gly Gly Ala Val Leu Arg Thr Ala Pro Thr Phe Asp Gln Ser 
        595                 600                 605             


Leu Ile Ala Ser Glu Ala Ser Gly Gln Lys Tyr Ala Ala Leu Pro Ser 
    610                 615                 620                 


Asn Gly Ser Ser Leu Gln Trp Thr Val Arg Gln Gly Gln Gly Gly Ala 
625                 630                 635                 640 


Gly Val Thr Met Arg Phe Thr Met Pro Asp Thr Ser Asp Gly Met Gly 
                645                 650                 655     


Gln Asn Gly Ser Leu Asp Val Tyr Val Asn Gly Thr Lys Ala Lys Thr 
            660                 665                 670         


Val Ser Leu Thr Ser Tyr Tyr Ser Trp Gln Tyr Phe Ser Gly Asp Met 
        675                 680                 685             


Pro Ala Asp Ala Pro Gly Gly Gly Arg Pro Leu Phe Arg Phe Asp Glu 
    690                 695                 700                 


Val His Phe Lys Leu Asp Thr Ala Leu Lys Pro Gly Asp Thr Ile Arg 
705                 710                 715                 720 


Val Gln Lys Gly Gly Asp Ser Leu Glu Tyr Gly Val Asp Phe Ile Glu 
                725                 730                 735     


Ile Glu Pro Ile Pro Ala Ala Val Ala Arg Pro Ala Asn Ser Val Ser 
            740                 745                 750         


Val Thr Glu Tyr Gly Ala Val Ala Asn Asp Gly Lys Asp Asp Leu Ala 
        755                 760                 765             


Ala Phe Lys Ala Ala Val Thr Ala Ala Val Ala Ala Gly Lys Ser Leu 
    770                 775                 780                 


Tyr Ile Pro Glu Gly Thr Phe His Leu Ser Ser Met Trp Glu Ile Gly 
785                 790                 795                 800 


Ser Ala Thr Ser Met Ile Asp Asn Phe Thr Val Thr Gly Ala Gly Ile 
                805                 810                 815     


Trp Tyr Thr Asn Ile Gln Phe Thr Asn Pro Asn Ala Ser Gly Gly Gly 
            820                 825                 830         


Ile Ser Leu Arg Ile Lys Gly Lys Leu Asp Phe Ser Asn Ile Tyr Met 
        835                 840                 845             


Asn Ser Asn Leu Arg Ser Arg Tyr Gly Gln Asn Ala Val Tyr Lys Gly 
    850                 855                 860                 


Phe Met Asp Asn Phe Gly Thr Asn Ser Ile Ile His Asp Val Trp Val 
865                 870                 875                 880 


Glu His Phe Glu Cys Gly Met Trp Val Gly Asp Tyr Ala His Thr Pro 
                885                 890                 895     


Ala Ile Tyr Ala Ser Gly Leu Val Val Glu Asn Ser Arg Ile Arg Asn 
            900                 905                 910         


Asn Leu Ala Asp Gly Ile Asn Phe Ser Gln Gly Thr Ser Asn Ser Thr 
        915                 920                 925             


Val Arg Asn Ser Ser Ile Arg Asn Asn Gly Asp Asp Gly Leu Ala Val 
    930                 935                 940                 


Trp Thr Ser Asn Thr Asn Gly Ala Pro Ala Gly Val Asn Asn Thr Phe 
945                 950                 955                 960 


Ser Tyr Asn Thr Ile Glu Asn Asn Trp Arg Ala Ala Ala Ile Ala Phe 
                965                 970                 975     


Phe Gly Gly Ser Gly His Lys Ala Asp His Asn Tyr Ile Ile Asp Cys 
            980                 985                 990         


Val Gly Gly Ser Gly Ile Arg Met  Asn Thr Val Phe Pro  Gly Tyr His 
        995                 1000                 1005             


Phe Gln  Asn Asn Thr Gly Ile  Thr Phe Ser Asp Thr  Thr Ile Ile 
    1010                 1015                 1020             


Asn Ser  Gly Thr Ser Gln Asp  Leu Tyr Asn Gly Glu  Arg Gly Ala 
    1025                 1030                 1035             


Ile Asp  Leu Glu Ala Ser Asn  Asp Ala Ile Lys Asn  Val Thr Phe 
    1040                 1045                 1050             


Thr Asn  Ile Asp Ile Ile Asn  Ala Gln Arg Asp Gly  Val Gln Ile 
    1055                 1060                 1065             


Gly Tyr  Gly Gly Gly Phe Glu  Asn Ile Val Phe Asn  Asn Ile Thr 
    1070                 1075                 1080             


Ile Asp  Gly Thr Gly Arg Asp  Gly Ile Ser Thr Ser  Arg Phe Ser 
    1085                 1090                 1095             


Gly Pro  His Leu Gly Ala Ala  Ile Tyr Thr Tyr Thr  Gly Asn Gly 
    1100                 1105                 1110             


Ser Ala  Thr Phe Asn Asn Leu  Val Thr Arg Asn Ile  Ala Tyr Ala 
    1115                 1120                 1125             


Gly Gly  Asn Tyr Ile Gln Ser  Gly Phe Asn Leu Thr  Ile 
    1130                 1135                 1140     


<210>  7
<211>  1308
<212>  DNA
<213>  Penicillium marneffei

<400>  7
atgaagcaaa ccacttccct cctcctctca gccatcgcgg caaccagcag cttcagcgga       60

ctaacagccg ctcaaaaact cgcctttgcg cacgtcgtcg tcggcaacac tgcagcacac      120

acccaatcca cctgggaaag cgacattact ctcgcccata actccggtct agatgccttt      180

gccttgaacg gtggattccc cgatggcaac atccccgcac aaatcgccaa cgcttttgcg      240

gcttgtgaag ccctttcaaa tggcttcaag ctattcattt cgtttgacta cctcggtggt      300

ggtcagccct ggcctgcctc agaggttgtg tctatgctga agcagtatgc cagttccgat      360

tgttatttgg cctatgatgg caagcccttt gtctcaactt ttgagggcac cggaaatatt      420

gcggattggg cgcacggagg tcccattcgg tcggcggtgg atgtttactt tgtgccggat      480

tggacgagtt tggggcctgc tgggattaag tcgtatctcg acaatatcga tggatttttc      540

agctggaaca tgtggcctgt aggtgcggcc gatatgaccg acgagcctga tttcgaatgg      600

ctcgatgcaa ttgggtccga caagacgtac atgatgggcg tttcgccatg gttcttccac      660

agtgcaagcg gaggcaccga ctgggtctgg cgtggtgatg acctctggga tgaccgatgg      720

attcaagtca cctgcgtcga ccctcaattt gtccaggtcg tcacatggaa cgactggggt      780

gaatcctcct acatcggccc cttcgtgacc gctagcgaag tccccgccgg ctcattagcc      840

tacgtcgaca acatgtcaca ccaaagcttc cttgacttct tgcctttcta catcgccacc      900

ttcaaaggcg acacattcaa catctcccgc gaccagatgc aatactggta ccgcctcgca      960

cccgccgcag caggcagcgc gtgcggcgta tacggcaatg atcccgatca aggccagact     1020

accgttgacg tcaactccat cgttcaggac aaggtgtttt tcagtgcttt gttgacggct     1080

gatgctactg taacggtgca gattggtagt aatgctgcgg tttcatatga tggtgttgct     1140

ggtatgaacc actggagtca ggactttaat ggccagaccg gcgcggttac gtttagtgtt     1200

gtcaggggtg gcgctacagt taagagtggt attggagccg agattacggc ttcgacttcg     1260

ttgtcgaatg ggtgcactaa ttacaaccct tgggttggta gtttctaa                  1308


<210>  8
<211>  435
<212>  PRT
<213>  Penicillium marneffei

<400>  8

Met Lys Gln Thr Thr Ser Leu Leu Leu Ser Ala Ile Ala Ala Thr Ser 
1               5                   10                  15      


Ser Phe Ser Gly Leu Thr Ala Ala Gln Lys Leu Ala Phe Ala His Val 
            20                  25                  30          


Val Val Gly Asn Thr Ala Ala His Thr Gln Ser Thr Trp Glu Ser Asp 
        35                  40                  45              


Ile Thr Leu Ala His Asn Ser Gly Leu Asp Ala Phe Ala Leu Asn Gly 
    50                  55                  60                  


Gly Phe Pro Asp Gly Asn Ile Pro Ala Gln Ile Ala Asn Ala Phe Ala 
65                  70                  75                  80  


Ala Cys Glu Ala Leu Ser Asn Gly Phe Lys Leu Phe Ile Ser Phe Asp 
                85                  90                  95      


Tyr Leu Gly Gly Gly Gln Pro Trp Pro Ala Ser Glu Val Val Ser Met 
            100                 105                 110         


Leu Lys Gln Tyr Ala Ser Ser Asp Cys Tyr Leu Ala Tyr Asp Gly Lys 
        115                 120                 125             


Pro Phe Val Ser Thr Phe Glu Gly Thr Gly Asn Ile Ala Asp Trp Ala 
    130                 135                 140                 


His Gly Gly Pro Ile Arg Ser Ala Val Asp Val Tyr Phe Val Pro Asp 
145                 150                 155                 160 


Trp Thr Ser Leu Gly Pro Ala Gly Ile Lys Ser Tyr Leu Asp Asn Ile 
                165                 170                 175     


Asp Gly Phe Phe Ser Trp Asn Met Trp Pro Val Gly Ala Ala Asp Met 
            180                 185                 190         


Thr Asp Glu Pro Asp Phe Glu Trp Leu Asp Ala Ile Gly Ser Asp Lys 
        195                 200                 205             


Thr Tyr Met Met Gly Val Ser Pro Trp Phe Phe His Ser Ala Ser Gly 
    210                 215                 220                 


Gly Thr Asp Trp Val Trp Arg Gly Asp Asp Leu Trp Asp Asp Arg Trp 
225                 230                 235                 240 


Ile Gln Val Thr Cys Val Asp Pro Gln Phe Val Gln Val Val Thr Trp 
                245                 250                 255     


Asn Asp Trp Gly Glu Ser Ser Tyr Ile Gly Pro Phe Val Thr Ala Ser 
            260                 265                 270         


Glu Val Pro Ala Gly Ser Leu Ala Tyr Val Asp Asn Met Ser His Gln 
        275                 280                 285             


Ser Phe Leu Asp Phe Leu Pro Phe Tyr Ile Ala Thr Phe Lys Gly Asp 
    290                 295                 300                 


Thr Phe Asn Ile Ser Arg Asp Gln Met Gln Tyr Trp Tyr Arg Leu Ala 
305                 310                 315                 320 


Pro Ala Ala Ala Gly Ser Ala Cys Gly Val Tyr Gly Asn Asp Pro Asp 
                325                 330                 335     


Gln Gly Gln Thr Thr Val Asp Val Asn Ser Ile Val Gln Asp Lys Val 
            340                 345                 350         


Phe Phe Ser Ala Leu Leu Thr Ala Asp Ala Thr Val Thr Val Gln Ile 
        355                 360                 365             


Gly Ser Asn Ala Ala Val Ser Tyr Asp Gly Val Ala Gly Met Asn His 
    370                 375                 380                 


Trp Ser Gln Asp Phe Asn Gly Gln Thr Gly Ala Val Thr Phe Ser Val 
385                 390                 395                 400 


Val Arg Gly Gly Ala Thr Val Lys Ser Gly Ile Gly Ala Glu Ile Thr 
                405                 410                 415     


Ala Ser Thr Ser Leu Ser Asn Gly Cys Thr Asn Tyr Asn Pro Trp Val 
            420                 425                 430         


Gly Ser Phe 
        435 


<210>  9
<211>  8616
<212>  DNA
<213>  artificial sequence

<220>
<223>  plasmid pTrex

<400>  9
aagcttaact agtacttctc gagctctgta catgtccggt cgcgacgtac gcgtatcgat       60

ggcgccagct gcaggcggcc gcctgcagcc acttgcagtc ccgtggaatt ctcacggtga      120

atgtaggcct tttgtagggt aggaattgtc actcaagcac ccccaacctc cattacgcct      180

cccccataga gttcccaatc agtgagtcat ggcactgttc tcaaatagat tggggagaag      240

ttgacttccg cccagagctg aaggtcgcac aaccgcatga tatagggtcg gcaacggcaa      300

aaaagcacgt ggctcaccga aaagcaagat gtttgcgatc taacatccag gaacctggat      360

acatccatca tcacgcacga ccactttgat ctgctggtaa actcgtattc gccctaaacc      420

gaagtgcgtg gtaaatctac acgtgggccc ctttcggtat actgcgtgtg tcttctctag      480

gtgccattct tttcccttcc tctagtgttg aattgtttgt gttggagtcc gagctgtaac      540

tacctctgaa tctctggaga atggtggact aacgactacc gtgcacctgc atcatgtata      600

taatagtgat cctgagaagg ggggtttgga gcaatgtggg actttgatgg tcatcaaaca      660

aagaacgaag acgcctcttt tgcaaagttt tgtttcggct acggtgaaga actggatact      720

tgttgtgtct tctgtgtatt tttgtggcaa caagaggcca gagacaatct attcaaacac      780

caagcttgct cttttgagct acaagaacct gtggggtata tatctagagt tgtgaagtcg      840

gtaatcccgc tgtatagtaa tacgagtcgc atctaaatac tccgaagctg ctgcgaaccc      900

ggagaatcga gatgtgctgg aaagcttcta gcgagcggct aaattagcat gaaaggctat      960

gagaaattct ggagacggct tgttgaatca tggcgttcca ttcttcgaca agcaaagcgt     1020

tccgtcgcag tagcaggcac tcattcccga aaaaactcgg agattcctaa gtagcgatgg     1080

aaccggaata atataatagg caatacattg agttgcctcg acggttgcaa tgcaggggta     1140

ctgagcttgg acataactgt tccgtacccc acctcttctc aacctttggc gtttccctga     1200

ttcagcgtac ccgtacaagt cgtaatcact attaacccag actgaccgga cgtgttttgc     1260

ccttcatttg gagaaataat gtcattgcga tgtgtaattt gcctgcttga ccgactgggg     1320

ctgttcgaag cccgaatgta ggattgttat ccgaactctg ctcgtagagg catgttgtga     1380

atctgtgtcg ggcaggacac gcctcgaagg ttcacggcaa gggaaaccac cgatagcagt     1440

gtctagtagc aacctgtaaa gccgcaatgc agcatcactg gaaaatacaa accaatggct     1500

aaaagtacat aagttaatgc ctaaagaagt catataccag cggctaataa ttgtacaatc     1560

aagtggctaa acgtaccgta atttgccaac ggcttgtggg gttgcagaag caacggcaaa     1620

gccccacttc cccacgtttg tttcttcact cagtccaatc tcagctggtg atcccccaat     1680

tgggtcgctt gtttgttccg gtgaagtgaa agaagacaga ggtaagaatg tctgactcgg     1740

agcgttttgc atacaaccaa gggcagtgat ggaagacagt gaaatgttga cattcaagga     1800

gtatttagcc agggatgctt gagtgtatcg tgtaaggagg tttgtctgcc gatacgacga     1860

atactgtata gtcacttctg atgaagtggt ccatattgaa atgtaagtcg gcactgaaca     1920

ggcaaaagat tgagttgaaa ctgcctaaga tctcgggccc tcgggccttc ggcctttggg     1980

tgtacatgtt tgtgctccgg gcaaatgcaa agtgtggtag gatcgaacac actgctgcct     2040

ttaccaagca gctgagggta tgtgataggc aaatgttcag gggccactgc atggtttcga     2100

atagaaagag aagcttagcc aagaacaata gccgataaag atagcctcat taaacggaat     2160

gagctagtag gcaaagtcag cgaatgtgta tatataaagg ttcgaggtcc gtgcctccct     2220

catgctctcc ccatctactc atcaactcag atcctccagg agacttgtac accatctttt     2280

gaggcacaga aacccaatag tcaaccgcgg actgcgcatc atgtatcgga agttggccgt     2340

catctcggcc ttcttggcca cacctcgtgc tagactaggc gcgccgcgcg ccagctccgt     2400

gcgaaagcct gacgcaccgg tagattcttg gtgagcccgt atcatgacgg cggcgggagc     2460

tacatggccc cgggtgattt attttttttg tatctacttc tgaccctttt caaatatacg     2520

gtcaactcat ctttcactgg agatgcggcc tgcttggtat tgcgatgttg tcagcttggc     2580

aaattgtggc tttcgaaaac acaaaacgat tccttagtag ccatgcattt taagataacg     2640

gaatagaaga aagaggaaat taaaaaaaaa aaaaaaacaa acatcccgtt cataacccgt     2700

agaatcgccg ctcttcgtgt atcccagtac cagtttattt tgaatagctc gcccgctgga     2760

gagcatcctg aatgcaagta acaaccgtag aggctgacac ggcaggtgtt gctagggagc     2820

gtcgtgttct acaaggccag acgtcttcgc ggttgatata tatgtatgtt tgactgcagg     2880

ctgctcagcg acgacagtca agttcgccct cgctgcttgt gcaataatcg cagtggggaa     2940

gccacaccgt gactcccatc tttcagtaaa gctctgttgg tgtttatcag caatacacgt     3000

aatttaaact cgttagcatg gggctgatag cttaattacc gtttaccagt gccatggttc     3060

tgcagctttc cttggcccgt aaaattcggc gaagccagcc aatcaccagc taggcaccag     3120

ctaaacccta taattagtct cttatcaaca ccatccgctc ccccgggatc aatgaggaga     3180

atgaggggga tgcggggcta aagaagccta cataaccctc atgccaactc ccagtttaca     3240

ctcgtcgagc caacatcctg actataagct aacacagaat gcctcaatcc tgggaagaac     3300

tggccgctga taagcgcgcc cgcctcgcaa aaaccatccc tgatgaatgg aaagtccaga     3360

cgctgcctgc ggaagacagc gttattgatt tcccaaagaa atcggggatc ctttcagagg     3420

ccgaactgaa gatcacagag gcctccgctg cagatcttgt gtccaagctg gcggccggag     3480

agttgacctc ggtggaagtt acgctagcat tctgtaaacg ggcagcaatc gcccagcagt     3540

tagtagggtc ccctctacct ctcagggaga tgtaacaacg ccaccttatg ggactatcaa     3600

gctgacgctg gcttctgtgc agacaaactg cgcccacgag ttcttccctg acgccgctct     3660

cgcgcaggca agggaactcg atgaatacta cgcaaagcac aagagacccg ttggtccact     3720

ccatggcctc cccatctctc tcaaagacca gcttcgagtc aaggtacacc gttgccccta     3780

agtcgttaga tgtccctttt tgtcagctaa catatgccac cagggctacg aaacatcaat     3840

gggctacatc tcatggctaa acaagtacga cgaaggggac tcggttctga caaccatgct     3900

ccgcaaagcc ggtgccgtct tctacgtcaa gacctctgtc ccgcagaccc tgatggtctg     3960

cgagacagtc aacaacatca tcgggcgcac cgtcaaccca cgcaacaaga actggtcgtg     4020

cggcggcagt tctggtggtg agggtgcgat cgttgggatt cgtggtggcg tcatcggtgt     4080

aggaacggat atcggtggct cgattcgagt gccggccgcg ttcaacttcc tgtacggtct     4140

aaggccgagt catgggcggc tgccgtatgc aaagatggcg aacagcatgg agggtcagga     4200

gacggtgcac agcgttgtcg ggccgattac gcactctgtt gagggtgagt ccttcgcctc     4260

ttccttcttt tcctgctcta taccaggcct ccactgtcct cctttcttgc tttttatact     4320

atatacgaga ccggcagtca ctgatgaagt atgttagacc tccgcctctt caccaaatcc     4380

gtcctcggtc aggagccatg gaaatacgac tccaaggtca tccccatgcc ctggcgccag     4440

tccgagtcgg acattattgc ctccaagatc aagaacggcg ggctcaatat cggctactac     4500

aacttcgacg gcaatgtcct tccacaccct cctatcctgc gcggcgtgga aaccaccgtc     4560

gccgcactcg ccaaagccgg tcacaccgtg accccgtgga cgccatacaa gcacgatttc     4620

ggccacgatc tcatctccca tatctacgcg gctgacggca gcgccgacgt aatgcgcgat     4680

atcagtgcat ccggcgagcc ggcgattcca aatatcaaag acctactgaa cccgaacatc     4740

aaagctgtta acatgaacga gctctgggac acgcatctcc agaagtggaa ttaccagatg     4800

gagtaccttg agaaatggcg ggaggctgaa gaaaaggccg ggaaggaact ggacgccatc     4860

atcgcgccga ttacgcctac cgctgcggta cggcatgacc agttccggta ctatgggtat     4920

gcctctgtga tcaacctgct ggatttcacg agcgtggttg ttccggttac ctttgcggat     4980

aagaacatcg ataagaagaa tgagagtttc aaggcggtta gtgagcttga tgccctcgtg     5040

caggaagagt atgatccgga ggcgtaccat ggggcaccgg ttgcagtgca ggttatcgga     5100

cggagactca gtgaagagag gacgttggcg attgcagagg aagtggggaa gttgctggga     5160

aatgtggtga ctccatagct aataagtgtc agatagcaat ttgcacaaga aatcaatacc     5220

agcaactgta aataagcgct gaagtgacca tgccatgcta cgaaagagca gaaaaaaacc     5280

tgccgtagaa ccgaagagat atgacacgct tccatctctc aaaggaagaa tcccttcagg     5340

gttgcgtttc cagtctagac acgtataacg gcacaagtgt ctctcaccaa atgggttata     5400

tctcaaatgt gatctaagga tggaaagccc agaatatcga tcgcgcgcag atccatatat     5460

agggcccggg ttataattac ctcaggtcga cgtcccatgg ccattcgaat tcgtaatcat     5520

ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag     5580

ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg     5640

cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa     5700

tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca     5760

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     5820

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     5880

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     5940

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     6000

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     6060

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata     6120

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     6180

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     6240

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     6300

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     6360

gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     6420

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     6480

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     6540

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     6600

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     6660

atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga     6720

tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac     6780

gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg     6840

ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg     6900

caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt     6960

cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct     7020

cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat     7080

cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta     7140

agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca     7200

tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat     7260

agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac     7320

atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa     7380

ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt     7440

cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg     7500

caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat     7560

attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt     7620

agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtct     7680

aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg aggccctttc     7740

gtctcgcgcg tttcggtgat gacggtgaaa acctctgaca catgcagctc ccggagacgg     7800

tcacagcttg tctgtaagcg gatgccggga gcagacaagc ccgtcagggc gcgtcagcgg     7860

gtgttggcgg gtgtcggggc tggcttaact atgcggcatc agagcagatt gtactgagag     7920

tgcaccataa aattgtaaac gttaatattt tgttaaaatt cgcgttaaat ttttgttaaa     7980

tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat cccttataaa tcaaaagaat     8040

agcccgagat agggttgagt gttgttccag tttggaacaa gagtccacta ttaaagaacg     8100

tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg cgatggccca ctacgtgaac     8160

catcacccaa atcaagtttt ttggggtcga ggtgccgtaa agcactaaat cggaacccta     8220

aagggagccc ccgatttaga gcttgacggg gaaagccggc gaacgtggcg agaaaggaag     8280

ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag tgtagcggtc acgctgcgcg     8340

taaccaccac acccgccgcg cttaatgcgc cgctacaggg cgcgtactat ggttgctttg     8400

acgtatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca tcaggcgcca     8460

ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     8520

acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt     8580

ttcccagtca cgacgttgta aaacgacggc cagtgc                               8616


<210>  10
<211>  1772
<212>  PRT
<213>  Lactococcus reuteri

<400>  10

Met Glu Ile Lys Lys His Phe Lys Leu Tyr Lys Ser Gly Lys Gln Trp 
1               5                   10                  15      


Val Thr Ala Ala Val Ala Thr Val Ala Val Ser Thr Ala Leu Leu Tyr 
            20                  25                  30          


Gly Gly Val Ala His Ala Asp Gln Gln Val Gln Ser Ser Thr Thr Gln 
        35                  40                  45              


Glu Gln Thr Ser Thr Val Asn Ala Asp Thr Thr Lys Thr Val Asn Leu 
    50                  55                  60                  


Asp Thr Asn Thr Asp Gln Pro Ala Gln Thr Thr Asp Lys Asn Gln Val 
65                  70                  75                  80  


Ala Asn Asp Thr Thr Thr Asn Gln Ser Lys Thr Asp Ser Thr Ser Thr 
                85                  90                  95      


Thr Val Lys Asn Pro Thr Phe Ile Pro Val Ser Thr Leu Ser Ser Ser 
            100                 105                 110         


Asp Asn Glu Lys Gln Ser Gln Asn Tyr Asn Lys Pro Asp Asn Gly Asn 
        115                 120                 125             


Tyr Gly Asn Val Asp Ala Ala Tyr Phe Asn Asn Asn Gln Leu His Ile 
    130                 135                 140                 


Ser Gly Trp His Ala Thr Asn Ala Ser Gln Gly Thr Asp Ser Arg Gln 
145                 150                 155                 160 


Val Ile Val Arg Asp Ile Thr Thr Lys Thr Glu Leu Gly Arg Thr Asn 
                165                 170                 175     


Val Thr Asn Asn Val Leu Arg Pro Asp Val Lys Asn Val His Asn Val 
            180                 185                 190         


Tyr Asn Ala Asp Asn Ser Gly Phe Asp Val Asn Ile Asn Ile Asp Phe 
        195                 200                 205             


Ser Lys Met Lys Asp Tyr Arg Asp Ser Ile Glu Ile Val Ser Arg Tyr 
    210                 215                 220                 


Ser Gly Asn Gly Lys Ser Val Asp Trp Trp Ser Gln Pro Ile Thr Phe 
225                 230                 235                 240 


Asp Lys Asn Asn Tyr Ala Tyr Leu Asp Thr Phe Glu Val Lys Asn Gly 
                245                 250                 255     


Glu Leu His Ala Thr Gly Trp Asn Ala Thr Asn Lys Ala Ile Asn Tyr 
            260                 265                 270         


Asn His His Phe Val Ile Leu Phe Asp Arg Thr Asn Gly Lys Glu Val 
        275                 280                 285             


Thr Arg Gln Glu Val Arg Asp Gly Gln Ser Arg Pro Asp Val Ala Lys 
    290                 295                 300                 


Val Tyr Pro Gln Val Val Gly Ala Asn Asn Ser Gly Phe Asp Val Thr 
305                 310                 315                 320 


Phe Asn Ile Gly Asp Leu Asp Tyr Thr His Gln Tyr Gln Ile Leu Ser 
                325                 330                 335     


Arg Tyr Ser Asn Ala Asp Asn Gly Glu Gly Asp Tyr Val Thr Tyr Trp 
            340                 345                 350         


Phe Ala Pro Gln Ser Ile Ala Pro Ala Asn Gln Ser Asn Gln Gly Tyr 
        355                 360                 365             


Leu Asp Ser Phe Asp Ile Ser Lys Asn Gly Glu Val Thr Val Thr Gly 
    370                 375                 380                 


Trp Asn Ala Thr Asp Leu Ser Glu Leu Gln Thr Asn His Tyr Val Ile 
385                 390                 395                 400 


Leu Phe Asp Gln Thr Ala Gly Gln Gln Val Ala Ser Ala Lys Val Asp 
                405                 410                 415     


Leu Ile Ser Arg Pro Asp Val Ala Lys Ala Tyr Pro Thr Val Lys Thr 
            420                 425                 430         


Ala Glu Thr Ser Gly Phe Lys Val Thr Phe Lys Val Ser Asn Leu Gln 
        435                 440                 445             


Pro Gly His Gln Tyr Ser Val Val Ser Arg Phe Ser Ala Asp Glu Asn 
    450                 455                 460                 


Gly Asn Gly Asn Asp Lys Arg His Thr Asp Tyr Trp Tyr Ser Pro Val 
465                 470                 475                 480 


Thr Leu Asn Gln Thr Ala Ser Asn Ile Asp Thr Ile Thr Met Thr Ser 
                485                 490                 495     


Asn Gly Leu His Ile Thr Gly Trp Met Ala Ser Asp Asn Ser Ile Asn 
            500                 505                 510         


Glu Ala Thr Pro Tyr Ala Ile Ile Leu Asn Asn Gly Arg Glu Val Thr 
        515                 520                 525             


Arg Gln Lys Leu Thr Leu Ile Ala Arg Pro Asp Val Ala Ala Val Tyr 
    530                 535                 540                 


Pro Ser Leu Tyr Asn Ser Ala Val Ser Gly Phe Asp Thr Thr Ile Lys 
545                 550                 555                 560 


Leu Thr Asn Ala Gln Tyr Gln Ala Leu Asn Gly Gln Leu Gln Val Leu 
                565                 570                 575     


Leu Arg Phe Ser Lys Ala Val Asp Gly Asn Pro Asn Gly Thr Asn Thr 
            580                 585                 590         


Val Thr Asp Gln Phe Ser Lys Asn Tyr Ala Thr Thr Gly Gly Asn Phe 
        595                 600                 605             


Asp Tyr Val Lys Val Asn Gly Asn Gln Ile Glu Phe Ser Gly Trp His 
    610                 615                 620                 


Ala Thr Asn Gln Ser Asn Asp Lys Asn Ser Gln Trp Ile Ile Val Leu 
625                 630                 635                 640 


Val Asn Gly Lys Glu Val Lys Arg Gln Leu Val Asn Asp Thr Lys Asp 
                645                 650                 655     


Gly Ala Ala Gly Phe Asn Arg Asn Asp Val Tyr Lys Val Asn Pro Ala 
            660                 665                 670         


Ile Glu Asn Ser Ile Met Ser Gly Phe Gln Gly Ile Ile Thr Leu Pro 
        675                 680                 685             


Val Thr Val Lys Asp Glu Asn Val Gln Leu Val His Arg Phe Ser Asn 
    690                 695                 700                 


Asp Ala Lys Thr Gly Glu Gly Asn Tyr Val Asp Phe Trp Ser Glu Val 
705                 710                 715                 720 


Met Ser Val Lys Asp Ser Phe Gln Lys Gly Asn Gly Pro Leu Asn Gln 
                725                 730                 735     


Phe Gly Leu Gln Thr Ile Asn Gly Gln Gln Tyr Tyr Ile Asp Pro Thr 
            740                 745                 750         


Thr Gly Gln Pro Arg Lys Asn Phe Leu Leu Gln Asn Gly Asn Asp Trp 
        755                 760                 765             


Ile Tyr Phe Asp Lys Asp Thr Gly Ala Gly Thr Asn Ala Leu Lys Leu 
    770                 775                 780                 


Gln Phe Asp Lys Gly Thr Ile Ser Ala Asp Glu Gln Tyr Arg Arg Gly 
785                 790                 795                 800 


Asn Glu Ala Tyr Ser Tyr Asp Asp Lys Ser Ile Glu Asn Val Asn Gly 
                805                 810                 815     


Tyr Leu Thr Ala Asp Thr Trp Tyr Arg Pro Lys Gln Ile Leu Lys Asp 
            820                 825                 830         


Gly Thr Thr Trp Thr Asp Ser Lys Glu Thr Asp Met Arg Pro Ile Leu 
        835                 840                 845             


Met Val Trp Trp Pro Asn Thr Val Thr Gln Ala Tyr Tyr Leu Asn Tyr 
    850                 855                 860                 


Met Lys Gln Tyr Gly Asn Leu Leu Pro Ala Ser Leu Pro Ser Phe Ser 
865                 870                 875                 880 


Thr Asp Ala Asp Ser Ala Glu Leu Asn His Tyr Ser Glu Leu Val Gln 
                885                 890                 895     


Gln Asn Ile Glu Lys Arg Ile Ser Glu Thr Gly Ser Thr Asp Trp Leu 
            900                 905                 910         


Arg Thr Leu Met His Glu Phe Val Thr Lys Asn Ser Met Trp Asn Lys 
        915                 920                 925             


Asp Ser Glu Asn Val Asp Tyr Gly Gly Leu Gln Leu Gln Gly Gly Phe 
    930                 935                 940                 


Leu Lys Tyr Val Asn Ser Asp Leu Thr Lys Tyr Ala Asn Ser Asp Trp 
945                 950                 955                 960 


Arg Leu Met Asn Arg Thr Ala Thr Asn Ile Asp Gly Lys Asn Tyr Gly 
                965                 970                 975     


Gly Ala Glu Phe Leu Leu Ala Asn Asp Ile Asp Asn Ser Asn Pro Val 
            980                 985                 990         


Val Gln Ala Glu Glu Leu Asn Trp  Leu Tyr Tyr Leu Met  Asn Phe Gly 
        995                 1000                 1005             


Thr Ile  Thr Gly Asn Asn Pro  Glu Ala Asn Phe Asp  Gly Ile Arg 
    1010                 1015                 1020             


Val Asp  Ala Val Asp Asn Val  Asp Val Asp Leu Leu  Ser Ile Ala 
    1025                 1030                 1035             


Arg Asp  Tyr Phe Asn Ala Ala  Tyr Asn Met Glu Gln  Ser Asp Ala 
    1040                 1045                 1050             


Ser Ala  Asn Lys His Ile Asn  Ile Leu Glu Asp Trp  Gly Trp Asp 
    1055                 1060                 1065             


Asp Pro  Ala Tyr Val Asn Lys  Ile Gly Asn Pro Gln  Leu Thr Met 
    1070                 1075                 1080             


Asp Asp  Arg Leu Arg Asn Ala  Ile Met Asp Thr Leu  Ser Gly Ala 
    1085                 1090                 1095             


Pro Asp  Lys Asn Gln Ala Leu  Asn Lys Leu Ile Thr  Gln Ser Leu 
    1100                 1105                 1110             


Val Asn  Arg Ala Asn Asp Asn  Thr Glu Asn Ala Val  Ile Pro Ser 
    1115                 1120                 1125             


Tyr Asn  Phe Val Arg Ala His  Asp Ser Asn Ala Gln  Asp Gln Ile 
    1130                 1135                 1140             


Arg Gln  Ala Ile Gln Ala Ala  Thr Gly Lys Pro Tyr  Gly Glu Phe 
    1145                 1150                 1155             


Asn Leu  Asp Asp Glu Lys Lys  Gly Met Glu Ala Tyr  Ile Asn Asp 
    1160                 1165                 1170             


Gln Asn  Ser Thr Asn Lys Lys  Trp Asn Leu Tyr Asn  Met Pro Ser 
    1175                 1180                 1185             


Ala Tyr  Thr Ile Leu Leu Thr  Asn Lys Asp Ser Val  Pro Arg Val 
    1190                 1195                 1200             


Tyr Tyr  Gly Asp Leu Tyr Gln  Asp Gly Gly Gln Tyr  Met Glu His 
    1205                 1210                 1215             


Lys Thr  Arg Tyr Phe Asp Thr  Ile Thr Asn Leu Leu  Lys Thr Arg 
    1220                 1225                 1230             


Val Lys  Tyr Val Ala Gly Gly  Gln Thr Met Ser Val  Asp Lys Asn 
    1235                 1240                 1245             


Gly Ile  Leu Thr Asn Val Arg  Phe Gly Lys Gly Ala  Met Asn Ala 
    1250                 1255                 1260             


Thr Asp  Thr Gly Thr Asp Glu  Thr Arg Thr Glu Gly  Ile Gly Val 
    1265                 1270                 1275             


Val Ile  Ser Asn Asn Thr Asn  Leu Lys Leu Asn Asp  Gly Glu Ser 
    1280                 1285                 1290             


Val Val  Leu His Met Gly Ala  Ala His Lys Asn Gln  Lys Tyr Arg 
    1295                 1300                 1305             


Ala Val  Ile Leu Thr Thr Glu  Asp Gly Val Lys Asn  Tyr Thr Asn 
    1310                 1315                 1320             


Asp Thr  Asp Ala Pro Val Ala  Tyr Thr Asp Ala Asn  Gly Asp Leu 
    1325                 1330                 1335             


His Phe  Thr Asn Thr Asn Leu  Asp Gly Gln Gln Tyr  Thr Ala Val 
    1340                 1345                 1350             


Arg Gly  Tyr Ala Asn Pro Asp  Val Thr Gly Tyr Leu  Ala Val Trp 
    1355                 1360                 1365             


Val Pro  Ala Gly Ala Ala Asp  Asp Gln Asp Ala Arg  Thr Ala Pro 
    1370                 1375                 1380             


Ser Asp  Glu Ala His Thr Thr  Lys Thr Ala Tyr Arg  Ser Asn Ala 
    1385                 1390                 1395             


Ala Leu  Asp Ser Asn Val Ile  Tyr Glu Gly Phe Ser  Asn Phe Ile 
    1400                 1405                 1410             


Tyr Trp  Pro Thr Thr Glu Ser  Glu Arg Thr Asn Val  Arg Ile Ala 
    1415                 1420                 1425             


Gln Asn  Ala Asp Leu Phe Lys  Ser Trp Gly Ile Thr  Thr Phe Glu 
    1430                 1435                 1440             


Leu Ala  Pro Gln Tyr Asn Ser  Ser Lys Asp Gly Thr  Phe Leu Asp 
    1445                 1450                 1455             


Ser Ile  Ile Asp Asn Gly Tyr  Ala Phe Thr Asp Arg  Tyr Asp Leu 
    1460                 1465                 1470             


Gly Met  Ser Thr Pro Asn Lys  Tyr Gly Ser Asp Glu  Asp Leu Arg 
    1475                 1480                 1485             


Asn Ala  Leu Gln Ala Leu His  Lys Ala Gly Leu Gln  Ala Ile Ala 
    1490                 1495                 1500             


Asp Trp  Val Pro Asp Gln Ile  Tyr Asn Leu Pro Gly  Lys Glu Ala 
    1505                 1510                 1515             


Val Thr  Val Thr Arg Ser Asp  Asp His Gly Thr Thr  Trp Glu Val 
    1520                 1525                 1530             


Ser Pro  Ile Lys Asn Val Val  Tyr Ile Thr Asn Thr  Ile Gly Gly 
    1535                 1540                 1545             


Gly Glu  Tyr Gln Lys Lys Tyr  Gly Gly Glu Phe Leu  Asp Thr Leu 
    1550                 1555                 1560             


Gln Lys  Glu Tyr Pro Gln Leu  Phe Ser Gln Val Tyr  Pro Val Thr 
    1565                 1570                 1575             


Gln Thr  Thr Ile Asp Pro Ser  Val Lys Ile Lys Glu  Trp Ser Ala 
    1580                 1585                 1590             


Lys Tyr  Phe Asn Gly Thr Asn  Ile Leu His Arg Gly  Ala Gly Tyr 
    1595                 1600                 1605             


Val Leu  Arg Ser Asn Asp Gly  Lys Tyr Tyr Asn Leu  Gly Thr Ser 
    1610                 1615                 1620             


Thr Gln  Gln Phe Leu Pro Ser  Gln Leu Ser Val Gln  Asp Asn Glu 
    1625                 1630                 1635             


Gly Tyr  Gly Phe Val Lys Glu  Gly Asn Asn Tyr His  Tyr Tyr Asp 
    1640                 1645                 1650             


Glu Asn  Lys Gln Met Val Lys  Asp Ala Phe Ile Gln  Asp Ser Val 
    1655                 1660                 1665             


Gly Asn  Trp Tyr Tyr Phe Asp  Lys Asn Gly Asn Met  Val Ala Asn 
    1670                 1675                 1680             


Gln Ser  Pro Val Glu Ile Ser  Ser Asn Gly Ala Ser  Gly Thr Tyr 
    1685                 1690                 1695             


Leu Phe  Leu Asn Asn Gly Thr  Ser Phe Arg Ser Gly  Leu Val Lys 
    1700                 1705                 1710             


Thr Asp  Ala Gly Thr Tyr Tyr  Tyr Asp Gly Asp Gly  Arg Met Val 
    1715                 1720                 1725             


Arg Asn  Gln Thr Val Ser Asp  Gly Ala Met Thr Tyr  Val Leu Asp 
    1730                 1735                 1740             


Glu Asn  Gly Lys Leu Val Ser  Glu Ser Phe Asp Ser  Ser Ala Thr 
    1745                 1750                 1755             


Glu Ala  His Pro Leu Lys Pro  Gly Asp Leu Asn Gly  Gln Lys 
    1760                 1765                 1770         


<210>  11
<211>  5208
<212>  DNA
<213>  Lactobacillus reuteri

<400>  11
atggatcagc aagtacaaag cagcaccacc caggagcaga cgagcacggt taacgcggac       60

acgactaaaa ccgtcaatct ggataccaac actgaccagc cggctcagac gaccgataag      120

aatcaggtcg cgaatgatac caccaccaac caaagcaaga cggacagcac cagcacgacg      180

gttaagaatc cgacgtttat tcctgttagc actttgtcca gctccgataa cgaaaagcag      240

agccagaatt acaataaacc agataacggt aattacggta atgttgatgc ggcctacttc      300

aataacaatc agctgcacat tagcggttgg cacgcaacca acgcgagcca gggtacggat      360

agccgccaag taatcgtacg cgacattacc accaagaccg agctgggtcg tactaatgtg      420

accaacaatg ttctgcgtcc ggacgtgaaa aatgttcaca acgtctacaa cgctgacaac      480

agcggctttg atgtgaatat caatattgat ttcagcaaga tgaaagacta tcgtgacagc      540

atcgagatcg tttctcgtta tagcggcaac ggcaagagcg ttgactggtg gtcgcagccg      600

atcacgtttg acaaaaacaa ttatgcttat ctggacactt tcgaggtgaa gaacggtgaa      660

ctgcatgcaa cgggctggaa tgccaccaac aaggctatca attacaatca ccacttcgtt      720

attctgtttg atcgtacgaa tggcaaagaa gtcacccgcc aagaggtgcg tgatggtcaa      780

agccgtccgg atgtggcgaa ggtatacccg caagtcgttg gcgcgaacaa tagcggtttt      840

gacgttacgt ttaacattgg tgatttggac tacacccatc agtaccagat cctgtctcgt      900

tacagcaacg cagacaacgg tgaaggcgat tatgtgacct attggtttgc gccgcagagc      960

atcgctccgg cgaatcaaag caaccaaggt tacctggaca gcttcgatat ttcgaaaaac     1020

ggtgaggtga ccgtgacggg ttggaatgcg acggatctga gcgagttgca aacgaatcac     1080

tacgtgatcc tgtttgatca gacggcgggt caacaggttg catccgctaa ggtcgacctg     1140

atcagccgtc cagacgtcgc gaaggcgtac cctaccgtta aaacggcaga aacctccggt     1200

ttcaaggtca cgtttaaggt tagcaatctg caaccgggcc accaatacag cgtcgttagc     1260

cgctttagcg ccgatgaaaa cggtaatggc aacgacaaac gccacacgga ctactggtac     1320

tctccggtta ccctgaacca aacggctagc aacattgaca ctatcaccat gacttccaac     1380

ggtctgcaca tcaccggctg gatggcgagc gataatagca ttaacgaagc gaccccgtac     1440

gcgattatcc tgaacaacgg tcgcgaggtg acgcgccaga aactgaccct gatcgcgcgt     1500

ccggatgttg cggcagtgta tccgagcctg tacaatagcg cggttagcgg cttcgacacc     1560

accatcaagc tgactaacgc gcaatatcaa gcattgaacg gccagctgca agtgctgctg     1620

cgctttagca aggcggtgga cggtaacccg aatggtacca ataccgtcac ggatcaattt     1680

agcaaaaact acgcaacgac cggtggtaat ttcgattacg tcaaggttaa tggtaaccaa     1740

attgagtttt ctggctggca cgcgacgaat cagagcaatg ataagaacag ccaatggatt     1800

atcgtcttgg ttaacggtaa agaggtcaaa cgccagctgg tcaatgacac gaaagacggc     1860

gcagccggct tcaatcgtaa tgatgtgtat aaagtgaacc cagcgatcga aaatagcatt     1920

atgtctggct tccagggcat tatcacgttg ccggttacgg tgaaagacga aaacgtgcag     1980

ctggtgcacc gcttctccaa tgacgcaaaa acgggtgagg gcaattatgt cgatttctgg     2040

agcgaggtga tgtctgtgaa ggactctttc caaaagggta atggtccgct gaaccagttt     2100

ggcctgcaaa ccatcaacgg ccaacaatac tatattgacc cgacgaccgg ccagccgcgt     2160

aagaatttcc tgctgcaaaa cggcaacgat tggatttact tcgacaaaga cactggcgca     2220

ggcaccaacg cgctgaaatt gcagtttgat aagggcacga ttagcgctga cgaacaatac     2280

cgtcgcggca acgaggcgta ctcctacgat gataagagca ttgaaaatgt caacggttac     2340

ttgacggcgg acacgtggta ccgcccgaag cagatcctga aggatggcac cacttggacc     2400

gattccaaag aaaccgatat gcgtccgatc ttgatggtct ggtggccaaa cacggtgact     2460

caggcgtact atctgaacta catgaaacaa tatggcaatc tgctgccggc gagcctgccg     2520

agctttagca ccgacgccga tagcgcggag ttgaatcatt attccgagct ggtccaacag     2580

aatatcgaga aacgtattag cgagactggt agcactgatt ggctgcgtac cctgatgcac     2640

gagttcgtga cgaagaatag catgtggaac aaagatagcg agaacgttga ctacggtggc     2700

ctgcaactgc aaggtggttt cctgaagtac gttaacagcg acctgacgaa gtacgcaaac     2760

tctgattggc gtctgatgaa ccgtaccgcg acgaacattg acggtaagaa ttacggtggt     2820

gccgagtttc tgctggcgaa tgacatcgac aactctaacc cggtggtgca ggccgaagaa     2880

ttgaattggc tgtattatct gatgaacttc ggtaccatca ccggtaacaa cccagaagct     2940

aacttcgacg gcatccgtgt cgacgcggtc gataatgtgg atgttgatct gctgagcatt     3000

gcccgtgact actttaatgc agcgtataac atggaacaaa gcgatgctag cgcgaataag     3060

cacatcaata ttctggaaga ttggggctgg gacgatccgg cgtacgtgaa caaaatcggc     3120

aatccacagt tgaccatgga tgaccgcctg cgtaatgcaa ttatggacac cctgagcggt     3180

gcgccggata agaaccaagc gctgaacaag ctgattactc agtctctggt gaatcgcgca     3240

aatgataata ctgaaaacgc ggtgatccct tcctacaact ttgtccgcgc tcatgacagc     3300

aatgcccagg accagatccg tcaagcgatc caggcggcaa ccggcaaacc ttatggcgag     3360

ttcaacttgg atgatgagaa aaagggtatg gaggcttaca tcaatgacca aaatagcacc     3420

aataagaaat ggaacctgta caacatgccg agcgcatata ccatcctgct gacgaataag     3480

gactcggtcc cgcgtgtcta ctatggcgac ttgtaccagg atggtggcca gtacatggaa     3540

cacaaaactc gttactttga caccatcacg aatctgctga aaacccgcgt caagtatgtc     3600

gcaggcggcc agaccatgtc tgtggataag aatggcattt tgactaatgt ccgtttcggt     3660

aagggtgcga tgaacgcaac tgacacgggt accgatgaaa cccgcaccga aggtatcggc     3720

gttgttatca gcaacaatac gaatttgaaa ctgaatgacg gcgaaagcgt tgtgctgcac     3780

atgggcgctg cccataagaa tcagaagtat cgtgcagtga tcctgaccac ggaggacggt     3840

gtgaagaatt acaccaacga caccgatgcg ccggtcgcat acaccgacgc gaacggcgat     3900

ttgcatttca ccaatactaa cctggacggt cagcaatata ccgccgttcg tggctacgca     3960

aacccggacg ttacgggtta tctggccgtc tgggttcctg ctggtgccgc cgatgaccaa     4020

gacgcacgta ccgctccgag cgacgaggcc cacaccacga aaacggcgta tcgttccaat     4080

gcggcattgg actccaacgt catctacgaa ggcttttcga actttatcta ttggccgacg     4140

accgagagcg agcgcacgaa tgtccgcatc gcgcagaacg cggatctgtt caaatcgtgg     4200

ggtatcacca ccttcgagct ggcgccacag tacaatagca gcaaggacgg tacgtttctg     4260

gattcgatca ttgacaatgg ttacgcgttt accgatcgtt atgacctggg tatgtctacc     4320

ccgaacaagt acggtagcga tgaggatctg cgtaacgccc tgcaagcact gcacaaggcc     4380

ggtctgcaag ccatcgcaga ttgggttccg gaccaaatct acaatctgcc gggcaaagag     4440

gctgtcacgg ttactcgtag cgatgaccac ggcactacct gggaggttag cccgatcaag     4500

aatgtggtgt atatcactaa taccatcggt ggtggcgaat accagaaaaa gtatggtggt     4560

gaatttctgg acaccttgca aaaagaatat ccgcagctgt ttagccaagt ttacccggtg     4620

acccaaacga cgattgaccc tagcgttaag attaaagagt ggtccgcgaa gtacttcaat     4680

ggtactaata tcctgcatcg cggtgcgggt tacgtcctgc gtagcaatga tggtaagtat     4740

tacaacctgg gtactagcac ccagcagttc ctgccgagcc agctgagcgt tcaagataat     4800

gagggttacg gtttcgttaa agagggtaac aactatcact attatgacga gaacaaacaa     4860

atggttaagg acgcgtttat ccaggatagc gtcggcaatt ggtactattt tgataagaac     4920

ggcaatatgg ttgcaaacca aagcccggtt gaaatcagca gcaacggtgc gagcggcacc     4980

tacttgtttt tgaataatgg taccagcttc cgcagcggcc tggtcaaaac ggatgcaggc     5040

acctattact acgatggtga cggtcgcatg gttcgtaatc aaacggtttc tgacggtgcc     5100

atgacgtacg ttctggacga aaatggtaaa ctggtcagcg aatcttttga tagcagcgcg     5160

accgaggccc atccgctgaa accgggcgat ctgaacggtc aaaagtaa                  5208


<210>  12
<211>  1735
<212>  PRT
<213>  Lactobacillus reuteri

<400>  12

Met Asp Gln Gln Val Gln Ser Ser Thr Thr Gln Glu Gln Thr Ser Thr 
1               5                   10                  15      


Val Asn Ala Asp Thr Thr Lys Thr Val Asn Leu Asp Thr Asn Thr Asp 
            20                  25                  30          


Gln Pro Ala Gln Thr Thr Asp Lys Asn Gln Val Ala Asn Asp Thr Thr 
        35                  40                  45              


Thr Asn Gln Ser Lys Thr Asp Ser Thr Ser Thr Thr Val Lys Asn Pro 
    50                  55                  60                  


Thr Phe Ile Pro Val Ser Thr Leu Ser Ser Ser Asp Asn Glu Lys Gln 
65                  70                  75                  80  


Ser Gln Asn Tyr Asn Lys Pro Asp Asn Gly Asn Tyr Gly Asn Val Asp 
                85                  90                  95      


Ala Ala Tyr Phe Asn Asn Asn Gln Leu His Ile Ser Gly Trp His Ala 
            100                 105                 110         


Thr Asn Ala Ser Gln Gly Thr Asp Ser Arg Gln Val Ile Val Arg Asp 
        115                 120                 125             


Ile Thr Thr Lys Thr Glu Leu Gly Arg Thr Asn Val Thr Asn Asn Val 
    130                 135                 140                 


Leu Arg Pro Asp Val Lys Asn Val His Asn Val Tyr Asn Ala Asp Asn 
145                 150                 155                 160 


Ser Gly Phe Asp Val Asn Ile Asn Ile Asp Phe Ser Lys Met Lys Asp 
                165                 170                 175     


Tyr Arg Asp Ser Ile Glu Ile Val Ser Arg Tyr Ser Gly Asn Gly Lys 
            180                 185                 190         


Ser Val Asp Trp Trp Ser Gln Pro Ile Thr Phe Asp Lys Asn Asn Tyr 
        195                 200                 205             


Ala Tyr Leu Asp Thr Phe Glu Val Lys Asn Gly Glu Leu His Ala Thr 
    210                 215                 220                 


Gly Trp Asn Ala Thr Asn Lys Ala Ile Asn Tyr Asn His His Phe Val 
225                 230                 235                 240 


Ile Leu Phe Asp Arg Thr Asn Gly Lys Glu Val Thr Arg Gln Glu Val 
                245                 250                 255     


Arg Asp Gly Gln Ser Arg Pro Asp Val Ala Lys Val Tyr Pro Gln Val 
            260                 265                 270         


Val Gly Ala Asn Asn Ser Gly Phe Asp Val Thr Phe Asn Ile Gly Asp 
        275                 280                 285             


Leu Asp Tyr Thr His Gln Tyr Gln Ile Leu Ser Arg Tyr Ser Asn Ala 
    290                 295                 300                 


Asp Asn Gly Glu Gly Asp Tyr Val Thr Tyr Trp Phe Ala Pro Gln Ser 
305                 310                 315                 320 


Ile Ala Pro Ala Asn Gln Ser Asn Gln Gly Tyr Leu Asp Ser Phe Asp 
                325                 330                 335     


Ile Ser Lys Asn Gly Glu Val Thr Val Thr Gly Trp Asn Ala Thr Asp 
            340                 345                 350         


Leu Ser Glu Leu Gln Thr Asn His Tyr Val Ile Leu Phe Asp Gln Thr 
        355                 360                 365             


Ala Gly Gln Gln Val Ala Ser Ala Lys Val Asp Leu Ile Ser Arg Pro 
    370                 375                 380                 


Asp Val Ala Lys Ala Tyr Pro Thr Val Lys Thr Ala Glu Thr Ser Gly 
385                 390                 395                 400 


Phe Lys Val Thr Phe Lys Val Ser Asn Leu Gln Pro Gly His Gln Tyr 
                405                 410                 415     


Ser Val Val Ser Arg Phe Ser Ala Asp Glu Asn Gly Asn Gly Asn Asp 
            420                 425                 430         


Lys Arg His Thr Asp Tyr Trp Tyr Ser Pro Val Thr Leu Asn Gln Thr 
        435                 440                 445             


Ala Ser Asn Ile Asp Thr Ile Thr Met Thr Ser Asn Gly Leu His Ile 
    450                 455                 460                 


Thr Gly Trp Met Ala Ser Asp Asn Ser Ile Asn Glu Ala Thr Pro Tyr 
465                 470                 475                 480 


Ala Ile Ile Leu Asn Asn Gly Arg Glu Val Thr Arg Gln Lys Leu Thr 
                485                 490                 495     


Leu Ile Ala Arg Pro Asp Val Ala Ala Val Tyr Pro Ser Leu Tyr Asn 
            500                 505                 510         


Ser Ala Val Ser Gly Phe Asp Thr Thr Ile Lys Leu Thr Asn Ala Gln 
        515                 520                 525             


Tyr Gln Ala Leu Asn Gly Gln Leu Gln Val Leu Leu Arg Phe Ser Lys 
    530                 535                 540                 


Ala Val Asp Gly Asn Pro Asn Gly Thr Asn Thr Val Thr Asp Gln Phe 
545                 550                 555                 560 


Ser Lys Asn Tyr Ala Thr Thr Gly Gly Asn Phe Asp Tyr Val Lys Val 
                565                 570                 575     


Asn Gly Asn Gln Ile Glu Phe Ser Gly Trp His Ala Thr Asn Gln Ser 
            580                 585                 590         


Asn Asp Lys Asn Ser Gln Trp Ile Ile Val Leu Val Asn Gly Lys Glu 
        595                 600                 605             


Val Lys Arg Gln Leu Val Asn Asp Thr Lys Asp Gly Ala Ala Gly Phe 
    610                 615                 620                 


Asn Arg Asn Asp Val Tyr Lys Val Asn Pro Ala Ile Glu Asn Ser Ile 
625                 630                 635                 640 


Met Ser Gly Phe Gln Gly Ile Ile Thr Leu Pro Val Thr Val Lys Asp 
                645                 650                 655     


Glu Asn Val Gln Leu Val His Arg Phe Ser Asn Asp Ala Lys Thr Gly 
            660                 665                 670         


Glu Gly Asn Tyr Val Asp Phe Trp Ser Glu Val Met Ser Val Lys Asp 
        675                 680                 685             


Ser Phe Gln Lys Gly Asn Gly Pro Leu Asn Gln Phe Gly Leu Gln Thr 
    690                 695                 700                 


Ile Asn Gly Gln Gln Tyr Tyr Ile Asp Pro Thr Thr Gly Gln Pro Arg 
705                 710                 715                 720 


Lys Asn Phe Leu Leu Gln Asn Gly Asn Asp Trp Ile Tyr Phe Asp Lys 
                725                 730                 735     


Asp Thr Gly Ala Gly Thr Asn Ala Leu Lys Leu Gln Phe Asp Lys Gly 
            740                 745                 750         


Thr Ile Ser Ala Asp Glu Gln Tyr Arg Arg Gly Asn Glu Ala Tyr Ser 
        755                 760                 765             


Tyr Asp Asp Lys Ser Ile Glu Asn Val Asn Gly Tyr Leu Thr Ala Asp 
    770                 775                 780                 


Thr Trp Tyr Arg Pro Lys Gln Ile Leu Lys Asp Gly Thr Thr Trp Thr 
785                 790                 795                 800 


Asp Ser Lys Glu Thr Asp Met Arg Pro Ile Leu Met Val Trp Trp Pro 
                805                 810                 815     


Asn Thr Val Thr Gln Ala Tyr Tyr Leu Asn Tyr Met Lys Gln Tyr Gly 
            820                 825                 830         


Asn Leu Leu Pro Ala Ser Leu Pro Ser Phe Ser Thr Asp Ala Asp Ser 
        835                 840                 845             


Ala Glu Leu Asn His Tyr Ser Glu Leu Val Gln Gln Asn Ile Glu Lys 
    850                 855                 860                 


Arg Ile Ser Glu Thr Gly Ser Thr Asp Trp Leu Arg Thr Leu Met His 
865                 870                 875                 880 


Glu Phe Val Thr Lys Asn Ser Met Trp Asn Lys Asp Ser Glu Asn Val 
                885                 890                 895     


Asp Tyr Gly Gly Leu Gln Leu Gln Gly Gly Phe Leu Lys Tyr Val Asn 
            900                 905                 910         


Ser Asp Leu Thr Lys Tyr Ala Asn Ser Asp Trp Arg Leu Met Asn Arg 
        915                 920                 925             


Thr Ala Thr Asn Ile Asp Gly Lys Asn Tyr Gly Gly Ala Glu Phe Leu 
    930                 935                 940                 


Leu Ala Asn Asp Ile Asp Asn Ser Asn Pro Val Val Gln Ala Glu Glu 
945                 950                 955                 960 


Leu Asn Trp Leu Tyr Tyr Leu Met Asn Phe Gly Thr Ile Thr Gly Asn 
                965                 970                 975     


Asn Pro Glu Ala Asn Phe Asp Gly Ile Arg Val Asp Ala Val Asp Asn 
            980                 985                 990         


Val Asp Val Asp Leu Leu Ser Ile  Ala Arg Asp Tyr Phe  Asn Ala Ala 
        995                 1000                 1005             


Tyr Asn  Met Glu Gln Ser Asp  Ala Ser Ala Asn Lys  His Ile Asn 
    1010                 1015                 1020             


Ile Leu  Glu Asp Trp Gly Trp  Asp Asp Pro Ala Tyr  Val Asn Lys 
    1025                 1030                 1035             


Ile Gly  Asn Pro Gln Leu Thr  Met Asp Asp Arg Leu  Arg Asn Ala 
    1040                 1045                 1050             


Ile Met  Asp Thr Leu Ser Gly  Ala Pro Asp Lys Asn  Gln Ala Leu 
    1055                 1060                 1065             


Asn Lys  Leu Ile Thr Gln Ser  Leu Val Asn Arg Ala  Asn Asp Asn 
    1070                 1075                 1080             


Thr Glu  Asn Ala Val Ile Pro  Ser Tyr Asn Phe Val  Arg Ala His 
    1085                 1090                 1095             


Asp Ser  Asn Ala Gln Asp Gln  Ile Arg Gln Ala Ile  Gln Ala Ala 
    1100                 1105                 1110             


Thr Gly  Lys Pro Tyr Gly Glu  Phe Asn Leu Asp Asp  Glu Lys Lys 
    1115                 1120                 1125             


Gly Met  Glu Ala Tyr Ile Asn  Asp Gln Asn Ser Thr  Asn Lys Lys 
    1130                 1135                 1140             


Trp Asn  Leu Tyr Asn Met Pro  Ser Ala Tyr Thr Ile  Leu Leu Thr 
    1145                 1150                 1155             


Asn Lys  Asp Ser Val Pro Arg  Val Tyr Tyr Gly Asp  Leu Tyr Gln 
    1160                 1165                 1170             


Asp Gly  Gly Gln Tyr Met Glu  His Lys Thr Arg Tyr  Phe Asp Thr 
    1175                 1180                 1185             


Ile Thr  Asn Leu Leu Lys Thr  Arg Val Lys Tyr Val  Ala Gly Gly 
    1190                 1195                 1200             


Gln Thr  Met Ser Val Asp Lys  Asn Gly Ile Leu Thr  Asn Val Arg 
    1205                 1210                 1215             


Phe Gly  Lys Gly Ala Met Asn  Ala Thr Asp Thr Gly  Thr Asp Glu 
    1220                 1225                 1230             


Thr Arg  Thr Glu Gly Ile Gly  Val Val Ile Ser Asn  Asn Thr Asn 
    1235                 1240                 1245             


Leu Lys  Leu Asn Asp Gly Glu  Ser Val Val Leu His  Met Gly Ala 
    1250                 1255                 1260             


Ala His  Lys Asn Gln Lys Tyr  Arg Ala Val Ile Leu  Thr Thr Glu 
    1265                 1270                 1275             


Asp Gly  Val Lys Asn Tyr Thr  Asn Asp Thr Asp Ala  Pro Val Ala 
    1280                 1285                 1290             


Tyr Thr  Asp Ala Asn Gly Asp  Leu His Phe Thr Asn  Thr Asn Leu 
    1295                 1300                 1305             


Asp Gly  Gln Gln Tyr Thr Ala  Val Arg Gly Tyr Ala  Asn Pro Asp 
    1310                 1315                 1320             


Val Thr  Gly Tyr Leu Ala Val  Trp Val Pro Ala Gly  Ala Ala Asp 
    1325                 1330                 1335             


Asp Gln  Asp Ala Arg Thr Ala  Pro Ser Asp Glu Ala  His Thr Thr 
    1340                 1345                 1350             


Lys Thr  Ala Tyr Arg Ser Asn  Ala Ala Leu Asp Ser  Asn Val Ile 
    1355                 1360                 1365             


Tyr Glu  Gly Phe Ser Asn Phe  Ile Tyr Trp Pro Thr  Thr Glu Ser 
    1370                 1375                 1380             


Glu Arg  Thr Asn Val Arg Ile  Ala Gln Asn Ala Asp  Leu Phe Lys 
    1385                 1390                 1395             


Ser Trp  Gly Ile Thr Thr Phe  Glu Leu Ala Pro Gln  Tyr Asn Ser 
    1400                 1405                 1410             


Ser Lys  Asp Gly Thr Phe Leu  Asp Ser Ile Ile Asp  Asn Gly Tyr 
    1415                 1420                 1425             


Ala Phe  Thr Asp Arg Tyr Asp  Leu Gly Met Ser Thr  Pro Asn Lys 
    1430                 1435                 1440             


Tyr Gly  Ser Asp Glu Asp Leu  Arg Asn Ala Leu Gln  Ala Leu His 
    1445                 1450                 1455             


Lys Ala  Gly Leu Gln Ala Ile  Ala Asp Trp Val Pro  Asp Gln Ile 
    1460                 1465                 1470             


Tyr Asn  Leu Pro Gly Lys Glu  Ala Val Thr Val Thr  Arg Ser Asp 
    1475                 1480                 1485             


Asp His  Gly Thr Thr Trp Glu  Val Ser Pro Ile Lys  Asn Val Val 
    1490                 1495                 1500             


Tyr Ile  Thr Asn Thr Ile Gly  Gly Gly Glu Tyr Gln  Lys Lys Tyr 
    1505                 1510                 1515             


Gly Gly  Glu Phe Leu Asp Thr  Leu Gln Lys Glu Tyr  Pro Gln Leu 
    1520                 1525                 1530             


Phe Ser  Gln Val Tyr Pro Val  Thr Gln Thr Thr Ile  Asp Pro Ser 
    1535                 1540                 1545             


Val Lys  Ile Lys Glu Trp Ser  Ala Lys Tyr Phe Asn  Gly Thr Asn 
    1550                 1555                 1560             


Ile Leu  His Arg Gly Ala Gly  Tyr Val Leu Arg Ser  Asn Asp Gly 
    1565                 1570                 1575             


Lys Tyr  Tyr Asn Leu Gly Thr  Ser Thr Gln Gln Phe  Leu Pro Ser 
    1580                 1585                 1590             


Gln Leu  Ser Val Gln Asp Asn  Glu Gly Tyr Gly Phe  Val Lys Glu 
    1595                 1600                 1605             


Gly Asn  Asn Tyr His Tyr Tyr  Asp Glu Asn Lys Gln  Met Val Lys 
    1610                 1615                 1620             


Asp Ala  Phe Ile Gln Asp Ser  Val Gly Asn Trp Tyr  Tyr Phe Asp 
    1625                 1630                 1635             


Lys Asn  Gly Asn Met Val Ala  Asn Gln Ser Pro Val  Glu Ile Ser 
    1640                 1645                 1650             


Ser Asn  Gly Ala Ser Gly Thr  Tyr Leu Phe Leu Asn  Asn Gly Thr 
    1655                 1660                 1665             


Ser Phe  Arg Ser Gly Leu Val  Lys Thr Asp Ala Gly  Thr Tyr Tyr 
    1670                 1675                 1680             


Tyr Asp  Gly Asp Gly Arg Met  Val Arg Asn Gln Thr  Val Ser Asp 
    1685                 1690                 1695             


Gly Ala  Met Thr Tyr Val Leu  Asp Glu Asn Gly Lys  Leu Val Ser 
    1700                 1705                 1710             


Glu Ser  Phe Asp Ser Ser Ala  Thr Glu Ala His Pro  Leu Lys Pro 
    1715                 1720                 1725             


Gly Asp  Leu Asn Gly Gln Lys  
    1730                 1735 


<210>  13
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  13
ataaaaaacg ctcggttgcc gccgggcgtt ttttat                                 36


<210>  14
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  14
ggatcctgac tgcctgagct t                                                 21


