                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Activating JAK Kinase Biomarkers Predictive Of Anti-Immune 
       Checkpoint Inhibitor Response

<130>  DFS-139.25

<140>  PCT/US2015/32823
<141>  2015-05-28

<150>  62/003,698
<151>  2014-05-28

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  3465
<212>  DNA
<213>  Homo sapiens

<400>  1
atgcagtatc taaatataaa agaggactgc aatgccatgg ctttctgtgc taaaatgagg       60

agctccaaga agactgaggt gaacctggag gcccctgagc caggggtgga agtgatcttc      120

tatctgtcgg acagggagcc cctccggctg ggcagtggag agtacacagc agaggaactg      180

tgcatcaggg ctgcacaggc atgccgtatc tctcctcttt gtcacaacct ctttgccctg      240

tatgacgaga acaccaagct ctggtatgct ccaaatcgca ccatcaccgt tgatgacaag      300

atgtccctcc ggctccacta ccggatgagg ttctatttca ccaattggca tggaaccaac      360

gacaatgagc agtcagtgtg gcgtcattct ccaaagaagc agaaaaatgg ctacgagaaa      420

aaaaagattc cagatgcaac ccctctcctt gatgccagct cactggagta tctgtttgct      480

cagggacagt atgatttggt gaaatgcctg gctcctattc gagaccccaa gaccgagcag      540

gatggacatg atattgagaa cgagtgtcta gggatggctg tcctggccat ctcacactat      600

gccatgatga agaagatgca gttgccagaa ctgcccaagg acatcagcta caagcgatat      660

attccagaaa cattgaataa gtccatcaga cagaggaacc ttctcaccag gatgcggata      720

aataatgttt tcaaggattt cctaaaggaa tttaacaaca agaccatttg tgacagcagc      780

gtgtccacgc atgacctgaa ggtgaaatac ttggctacct tggaaacttt gacaaaacat      840

tacggtgctg aaatatttga gacttccatg ttactgattt catcagaaaa tgagatgaat      900

tggtttcatt cgaatgacgg tggaaacgtt ctctactacg aagtgatggt gactgggaat      960

cttggaatcc agtggaggca taaaccaaat gttgtttctg ttgaaaagga aaaaaataaa     1020

ctgaagcgga aaaaactgga aaataaacac aagaaggatg aggagaaaaa caagatccgg     1080

gaagagtgga acaatttttc ttacttccct gaaatcactc acattgtaat aaaggagtct     1140

gtggtcagca ttaacaagca ggacaacaag aaaatggaac tgaagctctc ttcccacgag     1200

gaggccttgt cctttgtgtc cctggtagat ggctacttcc ggctcacagc agatgcccat     1260

cattacctct gcaccgacgt ggcccccccg ttgatcgtcc acaacataca gaatggctgt     1320

catggtccaa tctgtacaga atacgccatc aataaattgc ggcaagaagg aagcgaggag     1380

gggatgtacg tgctgaggtg gagctgcacc gactttgaca acatcctcat gaccgtcacc     1440

tgctttgaga agtctgagca ggtgcagggt gcccagaagc agttcaagaa ctttcagatc     1500

gaggtgcaga agggccgcta cagtctgcac ggttcggacc gcagcttccc cagcttggga     1560

gacctcatga gccacctcaa gaagcagatc ctgcgcacgg ataacatcag cttcatgcta     1620

aaacgctgct gccagcccaa gccccgagaa atctccaacc tgctggtggc tactaagaaa     1680

gcccaggagt ggcagcccgt ctaccccatg agccagctga gtttcgatcg gatcctcaag     1740

aaggatctgg tgcagggcga gcaccttggg agaggcacga gaacacacat ctattctggg     1800

accctgatgg attacaagga tgacgaagga acttctgaag agaagaagat aaaagtgatc     1860

ctcaaagtct tagaccccag ccacagggat atttccctgg ccttcttcga ggcagccagc     1920

atgatgagac aggtctccca caaacacatc gtgtacctct atggcgtctg tgtccgcgac     1980

gtggagaata tcatggtgga agagtttgtg gaagggggtc ctctggatct cttcatgcac     2040

cggaaaagcg atgtccttac cacaccatgg aaattcaaag ttgccaaaca gctggccagt     2100

gccctgagct acttggagga taaagacctg gtccatggaa atgtgtgtac taaaaacctc     2160

ctcctggccc gtgagggcat cgacagtgag tgtggcccat tcatcaagct cagtgacccc     2220

ggcatcccca ttacggtgct gtctaggcaa gaatgcattg aacgaatccc atggattgct     2280

cctgagtgtg ttgaggactc caagaacctg agtgtggctg ctgacaagtg gagctttgga     2340

accacgctct gggaaatctg ctacaatggc gagatcccct tgaaagacaa gacgctgatt     2400

gagaaagaga gattctatga aagccggtgc aggccagtga caccatcatg taaggagctg     2460

gctgacctca tgacccgctg catgaactat gaccccaatc agaggccttt cttccgagcc     2520

atcatgagag acattaataa gcttgaagag cagaatccag atattgtttc agaaaaaaaa     2580

ccagcaactg aagtggaccc cacacatttt gaaaagcgct tcctaaagag gatccgtgac     2640

ttgggagagg gccactttgg gaaggttgag ctctgcaggt atgaccccga aggggacaat     2700

acaggggagc aggtggctgt taaatctctg aagcctgaga gtggaggtaa ccacatagct     2760

gatctgaaaa aggaaatcga gatcttaagg aacctctatc atgagaacat tgtgaagtac     2820

aaaggaatct gcacagaaga cggaggaaat ggtattaagc tcatcatgga atttctgcct     2880

tcgggaagcc ttaaggaata tcttccaaag aataagaaca aaataaacct caaacagcag     2940

ctaaaatatg ccgttcagat ttgtaagggg atggactatt tgggttctcg gcaatacgtt     3000

caccgggact tggcagcaag aaatgtcctt gttgagagtg aacaccaagt gaaaattgga     3060

gacttcggtt taaccaaagc aattgaaacc gataaggagt attacaccgt caaggatgac     3120

cgggacagcc ctgtgttttg gtatgctcca gaatgtttaa tgcaatctaa attttatatt     3180

gcctctgacg tctggtcttt tggagtcact ctgcatgagc tgctgactta ctgtgattca     3240

gattctagtc ccatggcttt gttcctgaaa atgataggcc caacccatgg ccagatgaca     3300

gtcacaagac ttgtgaatac gttaaaagaa ggaaaacgcc tgccgtgccc acctaactgt     3360

ccagatgagg tttatcaact tatgaggaaa tgctgggaat tccaaccatc caatcggaca     3420

agctttcaga accttattga aggatttgaa gcacttttaa aataa                     3465


<210>  2
<211>  1154
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
    210                 215                 220                 


Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
225                 230                 235                 240 


Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
                245                 250                 255     


Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
            260                 265                 270         


Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
        275                 280                 285             


Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 
    290                 295                 300                 


Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 
305                 310                 315                 320 


Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 
                325                 330                 335     


Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys 
            340                 345                 350         


Asp Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr 
        355                 360                 365             


Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 
    370                 375                 380                 


Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu 
385                 390                 395                 400 


Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr 
                405                 410                 415     


Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile 
            420                 425                 430         


Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr 
        435                 440                 445             


Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 
    450                 455                 460                 


Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr 
465                 470                 475                 480 


Cys Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys 
                485                 490                 495     


Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser 
            500                 505                 510         


Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys 
        515                 520                 525             


Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys 
    530                 535                 540                 


Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp 
                565                 570                 575     


Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly 
            580                 585                 590         


Thr Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp 
        595                 600                 605             


Glu Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu 
    610                 615                 620                 


Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser 
625                 630                 635                 640 


Met Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val 
                645                 650                 655     


Cys Val Arg Asp Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly 
            660                 665                 670         


Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp Val Leu Thr Thr 
        675                 680                 685             


Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr 
    690                 695                 700                 


Leu Glu Asp Lys Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu 
705                 710                 715                 720 


Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys 
                725                 730                 735     


Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys 
            740                 745                 750         


Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys 
        755                 760                 765             


Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp 
    770                 775                 780                 


Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile 
785                 790                 795                 800 


Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser 
                805                 810                 815     


Cys Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro 
            820                 825                 830         


Asn Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu 
        835                 840                 845             


Glu Glu Gln Asn Pro Asp Ile Val Ser Glu Lys Lys Pro Ala Thr Glu 
    850                 855                 860                 


Val Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp 
865                 870                 875                 880 


Leu Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro 
                885                 890                 895     


Glu Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro 
            900                 905                 910         


Glu Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile 
        915                 920                 925             


Leu Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys 
    930                 935                 940                 


Thr Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro 
945                 950                 955                 960 


Ser Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn 
                965                 970                 975     


Leu Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp 
            980                 985                 990         


Tyr Leu Gly Ser Arg Gln Tyr Val  His Arg Asp Leu Ala  Ala Arg Asn 
        995                 1000                 1005             


Val Leu  Val Glu Ser Glu His  Gln Val Lys Ile Gly  Asp Phe Gly 
    1010                 1015                 1020             


Leu Thr  Lys Ala Ile Glu Thr  Asp Lys Glu Tyr Tyr  Thr Val Lys 
    1025                 1030                 1035             


Asp Asp  Arg Asp Ser Pro Val  Phe Trp Tyr Ala Pro  Glu Cys Leu 
    1040                 1045                 1050             


Met Gln  Ser Lys Phe Tyr Ile  Ala Ser Asp Val Trp  Ser Phe Gly 
    1055                 1060                 1065             


Val Thr  Leu His Glu Leu Leu  Thr Tyr Cys Asp Ser  Asp Ser Ser 
    1070                 1075                 1080             


Pro Met  Ala Leu Phe Leu Lys  Met Ile Gly Pro Thr  His Gly Gln 
    1085                 1090                 1095             


Met Thr  Val Thr Arg Leu Val  Asn Thr Leu Lys Glu  Gly Lys Arg 
    1100                 1105                 1110             


Leu Pro  Cys Pro Pro Asn Cys  Pro Asp Glu Val Tyr  Gln Leu Met 
    1115                 1120                 1125             


Arg Lys  Cys Trp Glu Phe Gln  Pro Ser Asn Arg Thr  Ser Phe Gln 
    1130                 1135                 1140             


Asn Leu  Ile Glu Gly Phe Glu  Ala Leu Leu Lys 
    1145                 1150                 


<210>  3
<211>  3399
<212>  DNA
<213>  Homo sapiens

<400>  3
atgggaatgg cctgccttac gatgacagaa atggagggaa catccacctc ttctatatat       60

cagaatggtg atatttctgg aaatgccaat tctatgaagc aaatagatcc agttcttcag      120

gtgtatcttt accattccct tgggaaatct gaggcagatt atctgacctt tccatctggg      180

gagtatgttg cagaagaaat ctgtattgct gcttctaaag cttgtggtat cacacctgtg      240

tatcataata tgtttgcttt aatgagtgaa acagaaagga tctggtatcc acccaaccat      300

gtcttccata tagatgagtc aaccaggcat aatgtactct acagaataag attttacttt      360

cctcgttggt attgcagtgg cagcaacaga gcctatcggc atggaatatc tcgaggtgct      420

gaagctcctc ttcttgatga ctttgtcatg tcttacctct ttgctcagtg gcggcatgat      480

tttgtgcacg gatggataaa agtacctgtg actcatgaaa cacaggaaga atgtcttggg      540

atggcagtgt tagatatgat gagaatagcc aaagaaaacg atcaaacccc actggccatc      600

tataactcta tcagctacaa gacattctta ccaaaatgta ttcgagcaaa gatccaagac      660

tatcatattt tgacaaggaa gcgaataagg tacagatttc gcagatttat tcagcaattc      720

agccaatgca aagccactgc cagaaacttg aaacttaagt atcttataaa tctggaaact      780

ctgcagtctg ccttctacac agagaaattt gaagtaaaag aacctggaag tggtccttca      840

ggtgaggaga tttttgcaac cattataata actggaaacg gtggaattca gtggtcaaga      900

gggaaacata aagaaagtga gacactgaca gaacaggatt tacagttata ttgcgatttt      960

cctaatatta ttgatgtcag tattaagcaa gcaaaccaag agggttcaaa tgaaagccga     1020

gttgtaacta tccataagca agatggtaaa aatctggaaa ttgaacttag ctcattaagg     1080

gaagctttgt ctttcgtgtc attaattgat ggatattata gattaactgc agatgcacat     1140

cattacctct gtaaagaagt agcacctcca gccgtgcttg aaaatataca aagcaactgt     1200

catggcccaa tttcgatgga ttttgccatt agtaaactga agaaagcagg taatcagact     1260

ggactgtatg tacttcgatg cagtcctaag gactttaata aatatttttt gacttttgct     1320

gtcgagcgag aaaatgtcat tgaatataaa cactgtttga ttacaaaaaa tgagaatgaa     1380

gagtacaacc tcagtgggac aaagaagaac ttcagcagtc ttaaagatct tttgaattgt     1440

taccagatgg aaactgttcg ctcagacaat ataattttcc agtttactaa atgctgtccc     1500

ccaaagccaa aagataaatc aaaccttcta gtcttcagaa cgaatggtgt ttctgatgta     1560

ccaacctcac caacattaca gaggcctact catatgaacc aaatggtgtt tcacaaaatc     1620

agaaatgaag atttgatatt taatgaaagc cttggccaag gcacttttac aaagattttt     1680

aaaggcgtac gaagagaagt aggagactac ggtcaactgc atgaaacaga agttctttta     1740

aaagttctgg ataaagcaca cagaaactat tcagagtctt tctttgaagc agcaagtatg     1800

atgagcaagc tttctcacaa gcatttggtt ttaaattatg gagtatgtgt ctgtggagac     1860

gagaatattc tggttcagga gtttgtaaaa tttggatcac tagatacata tctgaaaaag     1920

aataaaaatt gtataaatat attatggaaa cttgaagttg ctaaacagtt ggcatgggcc     1980

atgcattttc tagaagaaaa cacccttatt catgggaatg tatgtgccaa aaatattctg     2040

cttatcagag aagaagacag gaagacagga aatcctcctt tcatcaaact tagtgatcct     2100

ggcattagta ttacagtttt gccaaaggac attcttcagg agagaatacc atgggtacca     2160

cctgaatgca ttgaaaatcc taaaaattta aatttggcaa cagacaaatg gagttttggt     2220

accactttgt gggaaatctg cagtggagga gataaacctc taagtgctct ggattctcaa     2280

agaaagctac aattttatga agataggcat cagcttcctg caccaaagtg ggcagaatta     2340

gcaaacctta taaataattg tatggattat gaaccagatt tcaggccttc tttcagagcc     2400

atcatacgag atcttaacag tttgtttact ccagattatg aactattaac agaaaatgac     2460

atgttaccaa atatgaggat aggtgccctg gggttttctg gtgcctttga agaccgggat     2520

cctacacagt ttgaagagag acatttgaaa tttctacagc aacttggcaa gggtaatttt     2580

gggagtgtgg agatgtgccg gtatgaccct ctacaggaca acactgggga ggtggtcgct     2640

gtaaaaaagc ttcagcatag tactgaagag cacctaagag actttgaaag ggaaattgaa     2700

atcctgaaat ccctacagca tgacaacatt gtaaagtaca agggagtgtg ctacagtgct     2760

ggtcggcgta atctaaaatt aattatggaa tatttaccat atggaagttt acgagactat     2820

cttcaaaaac ataaagaacg gatagatcac ataaaacttc tgcagtacac atctcagata     2880

tgcaagggta tggagtatct tggtacaaaa aggtatatcc acagggatct ggcaacgaga     2940

aatatattgg tggagaacga gaacagagtt aaaattggag attttgggtt aaccaaagtc     3000

ttgccacaag acaaagaata ctataaagta aaagaacctg gtgaaagtcc catattctgg     3060

tatgctccag aatcactgac agagagcaag ttttctgtgg cctcagatgt ttggagcttt     3120

ggagtggttc tgtatgaact tttcacatac attgagaaga gtaaaagtcc accagcggaa     3180

tttatgcgta tgattggcaa tgacaaacaa ggacagatga tcgtgttcca tttgatagaa     3240

cttttgaaga ataatggaag attaccaaga ccagatggat gcccagatga gatctatatg     3300

atcatgacag aatgctggaa caataatgta aatcaacgcc cctcctttag ggatctagct     3360

cttcgagtgg atcaaataag ggataacatg gctggatga                            3399


<210>  4
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Gly Thr Ser Thr 
1               5                   10                  15      


Ser Ser Ile Tyr Gln Asn Gly Asp Ile Ser Gly Asn Ala Asn Ser Met 
            20                  25                  30          


Lys Gln Ile Asp Pro Val Leu Gln Val Tyr Leu Tyr His Ser Leu Gly 
        35                  40                  45              


Lys Ser Glu Ala Asp Tyr Leu Thr Phe Pro Ser Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Ile Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Asn Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Arg His Asn Val 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Arg Trp Tyr Cys Ser Gly Ser 
        115                 120                 125             


Asn Arg Ala Tyr Arg His Gly Ile Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ser Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Val His Gly Trp Ile Lys Val Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Ile Ala Lys Glu 
            180                 185                 190         


Asn Asp Gln Thr Pro Leu Ala Ile Tyr Asn Ser Ile Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Ile Arg Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Gln Gln Phe 
225                 230                 235                 240 


Ser Gln Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Lys Phe Glu Val 
            260                 265                 270         


Lys Glu Pro Gly Ser Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys His Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Leu Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asn Ile Ile Asp Val Ser Ile Lys Gln Ala Asn Gln Glu Gly Ser 
                325                 330                 335     


Asn Glu Ser Arg Val Val Thr Ile His Lys Gln Asp Gly Lys Asn Leu 
            340                 345                 350         


Glu Ile Glu Leu Ser Ser Leu Arg Glu Ala Leu Ser Phe Val Ser Leu 
        355                 360                 365             


Ile Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys 
    370                 375                 380                 


Lys Glu Val Ala Pro Pro Ala Val Leu Glu Asn Ile Gln Ser Asn Cys 
385                 390                 395                 400 


His Gly Pro Ile Ser Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala 
                405                 410                 415     


Gly Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe 
            420                 425                 430         


Asn Lys Tyr Phe Leu Thr Phe Ala Val Glu Arg Glu Asn Val Ile Glu 
        435                 440                 445             


Tyr Lys His Cys Leu Ile Thr Lys Asn Glu Asn Glu Glu Tyr Asn Leu 
    450                 455                 460                 


Ser Gly Thr Lys Lys Asn Phe Ser Ser Leu Lys Asp Leu Leu Asn Cys 
465                 470                 475                 480 


Tyr Gln Met Glu Thr Val Arg Ser Asp Asn Ile Ile Phe Gln Phe Thr 
                485                 490                 495     


Lys Cys Cys Pro Pro Lys Pro Lys Asp Lys Ser Asn Leu Leu Val Phe 
            500                 505                 510         


Arg Thr Asn Gly Val Ser Asp Val Pro Thr Ser Pro Thr Leu Gln Arg 
        515                 520                 525             


Pro Thr His Met Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp 
    530                 535                 540                 


Leu Ile Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe 
545                 550                 555                 560 


Lys Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Glu Thr 
                565                 570                 575     


Glu Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu 
            580                 585                 590         


Ser Phe Phe Glu Ala Ala Ser Met Met Ser Lys Leu Ser His Lys His 
        595                 600                 605             


Leu Val Leu Asn Tyr Gly Val Cys Val Cys Gly Asp Glu Asn Ile Leu 
    610                 615                 620                 


Val Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys 
625                 630                 635                 640 


Asn Lys Asn Cys Ile Asn Ile Leu Trp Lys Leu Glu Val Ala Lys Gln 
                645                 650                 655     


Leu Ala Trp Ala Met His Phe Leu Glu Glu Asn Thr Leu Ile His Gly 
            660                 665                 670         


Asn Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Lys 
        675                 680                 685             


Thr Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile 
    690                 695                 700                 


Thr Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro 
705                 710                 715                 720 


Pro Glu Cys Ile Glu Asn Pro Lys Asn Leu Asn Leu Ala Thr Asp Lys 
                725                 730                 735     


Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys 
            740                 745                 750         


Pro Leu Ser Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp 
        755                 760                 765             


Arg His Gln Leu Pro Ala Pro Lys Trp Ala Glu Leu Ala Asn Leu Ile 
    770                 775                 780                 


Asn Asn Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ser Phe Arg Ala 
785                 790                 795                 800 


Ile Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu 
                805                 810                 815     


Thr Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe 
            820                 825                 830         


Ser Gly Ala Phe Glu Asp Arg Asp Pro Thr Gln Phe Glu Glu Arg His 
        835                 840                 845             


Leu Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
    850                 855                 860                 


Met Cys Arg Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Val Val Ala 
865                 870                 875                 880 


Val Lys Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu 
                885                 890                 895     


Arg Glu Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys 
            900                 905                 910         


Tyr Lys Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Lys Leu Ile 
        915                 920                 925             


Met Glu Tyr Leu Pro Tyr Gly Ser Leu Arg Asp Tyr Leu Gln Lys His 
    930                 935                 940                 


Lys Glu Arg Ile Asp His Ile Lys Leu Leu Gln Tyr Thr Ser Gln Ile 
945                 950                 955                 960 


Cys Lys Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp 
                965                 970                 975     


Leu Ala Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile 
            980                 985                 990         


Gly Asp Phe Gly Leu Thr Lys Val  Leu Pro Gln Asp Lys  Glu Tyr Tyr 
        995                 1000                 1005             


Lys Val  Lys Glu Pro Gly Glu  Ser Pro Ile Phe Trp  Tyr Ala Pro 
    1010                 1015                 1020             


Glu Ser  Leu Thr Glu Ser Lys  Phe Ser Val Ala Ser  Asp Val Trp 
    1025                 1030                 1035             


Ser Phe  Gly Val Val Leu Tyr  Glu Leu Phe Thr Tyr  Ile Glu Lys 
    1040                 1045                 1050             


Ser Lys  Ser Pro Pro Ala Glu  Phe Met Arg Met Ile  Gly Asn Asp 
    1055                 1060                 1065             


Lys Gln  Gly Gln Met Ile Val  Phe His Leu Ile Glu  Leu Leu Lys 
    1070                 1075                 1080             


Asn Asn  Gly Arg Leu Pro Arg  Pro Asp Gly Cys Pro  Asp Glu Ile 
    1085                 1090                 1095             


Tyr Met  Ile Met Thr Glu Cys  Trp Asn Asn Asn Val  Asn Gln Arg 
    1100                 1105                 1110             


Pro Ser  Phe Arg Asp Leu Ala  Leu Arg Val Asp Gln  Ile Arg Asp 
    1115                 1120                 1125             


Asn Met  Ala Gly 
    1130         


<210>  5
<211>  3375
<212>  DNA
<213>  Homo sapiens

<400>  5
atggcacctc caagtgaaga gacgcccctg atccctcagc gttcatgcag cctcttgtcc       60

acggaggctg gtgccctgca tgtgctgctg cccgctcggg gccccgggcc cccccagcgc      120

ctatctttct cctttgggga ccacttggct gaggacctgt gcgtgcaggc tgccaaggcc      180

agcggcatcc tgcctgtgta ccactccctc tttgctctgg ccacggagga cctgtcctgc      240

tggttccccc cgagccacat cttctccgtg gaggatgcca gcacccaagt cctgctgtac      300

aggattcgct tttacttccc caattggttt gggctggaga agtgccaccg cttcgggcta      360

cgcaaggatt tggccagtgc tatccttgac ctgccagtcc tggagcacct ctttgcccag      420

caccgcagtg acctggtgag tgggcgcctc cccgtgggcc tcagtctcaa ggagcagggt      480

gagtgtctca gcctggccgt gttggacctg gcccggatgg cgcgagagca ggcccagcgg      540

ccgggagagc tgctgaagac tgtcagctac aaggcctgcc tacccccaag cctgcgcgac      600

ctgatccagg gcctgagctt cgtgacgcgg aggcgtattc ggaggacggt gcgcagagcc      660

ctgcgccgcg tggccgcctg ccaggcagac cggcactcgc tcatggccaa gtacatcatg      720

gacctggagc ggctggatcc agccggggcc gccgagacct tccacgtggg cctccctggg      780

gcccttggtg gccacgacgg gctggggctg ctccgcgtgg ctggtgacgg cggcatcgcc      840

tggacccagg gagaacagga ggtcctccag cccttctgcg actttccaga aatcgtagac      900

attagcatca agcaggcccc gcgcgttggc ccggccggag agcaccgcct ggtcactgtt      960

accaggacag acaaccagat tttagaggcc gagttcccag ggctgcccga ggctctgtcg     1020

ttcgtggcgc tcgtggacgg ctacttccgg ctgaccacgg actcccagca cttcttctgc     1080

aaggaggtgg caccgccgag gctgctggag gaagtggccg agcagtgcca cggccccatc     1140

actctggact ttgccatcaa caagctcaag actgggggct cacgtcctgg ctcctatgtt     1200

ctccgccgca gcccccagga ctttgacagc ttcctcctca ctgtctgtgt ccagaacccc     1260

cttggtcctg attataaggg ctgcctcatc cggcgcagcc ccacaggaac cttccttctg     1320

gttggcctca gccgacccca cagcagtctt cgagagctcc tggcaacctg ctgggatggg     1380

gggctgcacg tagatggggt ggcagtgacc ctcacttcct gctgtatccc cagacccaaa     1440

gaaaagtcca acctgatcgt ggtccagaga ggtcacagcc cacccacatc atccttggtt     1500

cagccccaat cccaatacca gctgagtcag atgacatttc acaagatccc tgctgacagc     1560

ctggagtggc atgagaacct gggccatggg tccttcacca agatttaccg gggctgtcgc     1620

catgaggtgg tggatgggga ggcccgaaag acagaggtgc tgctgaaggt catggatgcc     1680

aagcacaaga actgcatgga gtcattcctg gaagcagcga gcttgatgag ccaagtgtcg     1740

taccggcatc tcgtgctgct ccacggcgtg tgcatggctg gagacagcac catggtgcag     1800

gaatttgtac acctgggggc catagacatg tatctgcgaa aacgtggcca cctggtgcca     1860

gccagctgga agctgcaggt ggtcaaacag ctggcctacg ccctcaacta tctggaggac     1920

aaaggcctgc cccatggcaa tgtctctgcc cggaaggtgc tcctggctcg ggagggggct     1980

gatgggagcc cgcccttcat caagctgagt gaccctgggg tcagccccgc tgtgttaagc     2040

ctggagatgc tcaccgacag gatcccctgg gtggcccccg agtgtctccg ggaggcgcag     2100

acacttagct tggaagctga caagtggggc ttcggcgcca cggtctggga agtgtttagt     2160

ggcgtcacca tgcccatcag tgccctggat cctgctaaga aactccaatt ttatgaggac     2220

cggcagcagc tgccggcccc caagtggaca gagctggccc tgctgattca acagtgcatg     2280

gcctatgagc cggtccagag gccctccttc cgagccgtca ttcgtgacct caatagcctc     2340

atctcttcag actatgagct cctctcagac cccacacctg gtgccctggc acctcgtgat     2400

gggctgtgga atggtgccca gctctatgcc tgccaagacc ccacgatctt cgaggagaga     2460

cacctcaagt acatctcaca gctgggcaag ggcaactttg gcagcgtgga gctgtgccgc     2520

tatgacccgc taggcgacaa tacaggtgcc ctggtggccg tgaaacagct gcagcacagc     2580

gggccagacc agcagaggga ctttcagcgg gagattcaga tcctcaaagc actgcacagt     2640

gatttcattg tcaagtatcg tggtgtcagc tatggcccgg gccgccagag cctgcggctg     2700

gtcatggagt acctgcccag cggctgcttg cgcgacttcc tgcagcggca ccgcgcgcgc     2760

ctcgatgcca gccgcctcct tctctattcc tcgcagatct gcaagggcat ggagtacctg     2820

ggctcccgcc gctgcgtgca ccgcgacctg gccgcccgaa acatcctcgt ggagagcgag     2880

gcacacgtca agatcgctga cttcggccta gctaagctgc tgccgcttga caaagactac     2940

tacgtggtcc gcgagccagg ccagagcccc attttctggt atgcccccga atccctctcg     3000

gacaacatct tctctcgcca gtcagacgtc tggagcttcg gggtcgtcct gtacgagctc     3060

ttcacctact gcgacaaaag ctgcagcccc tcggccgagt tcctgcggat gatgggatgt     3120

gagcgggatg tccccgccct ctgccgcctc ttggaactgc tggaggaggg ccagaggctg     3180

ccggcgcctc ctgcctgccc tgctgaggtt cacgagctca tgaagctgtg ctgggcccct     3240

agcccacagg accggccatc attcagcgcc ctgggccccc agctggacat gctgtggagc     3300

ggaagccggg ggtgtgagac tcatgccttc actgctcacc cagagggcaa acaccactcc     3360

ctgtcctttt catag                                                      3375


<210>  6
<211>  1124
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Pro Pro Ser Glu Glu Thr Pro Leu Ile Pro Gln Arg Ser Cys 
1               5                   10                  15      


Ser Leu Leu Ser Thr Glu Ala Gly Ala Leu His Val Leu Leu Pro Ala 
            20                  25                  30          


Arg Gly Pro Gly Pro Pro Gln Arg Leu Ser Phe Ser Phe Gly Asp His 
        35                  40                  45              


Leu Ala Glu Asp Leu Cys Val Gln Ala Ala Lys Ala Ser Gly Ile Leu 
    50                  55                  60                  


Pro Val Tyr His Ser Leu Phe Ala Leu Ala Thr Glu Asp Leu Ser Cys 
65                  70                  75                  80  


Trp Phe Pro Pro Ser His Ile Phe Ser Val Glu Asp Ala Ser Thr Gln 
                85                  90                  95      


Val Leu Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Asn Trp Phe Gly Leu 
            100                 105                 110         


Glu Lys Cys His Arg Phe Gly Leu Arg Lys Asp Leu Ala Ser Ala Ile 
        115                 120                 125             


Leu Asp Leu Pro Val Leu Glu His Leu Phe Ala Gln His Arg Ser Asp 
    130                 135                 140                 


Leu Val Ser Gly Arg Leu Pro Val Gly Leu Ser Leu Lys Glu Gln Gly 
145                 150                 155                 160 


Glu Cys Leu Ser Leu Ala Val Leu Asp Leu Ala Arg Met Ala Arg Glu 
                165                 170                 175     


Gln Ala Gln Arg Pro Gly Glu Leu Leu Lys Thr Val Ser Tyr Lys Ala 
            180                 185                 190         


Cys Leu Pro Pro Ser Leu Arg Asp Leu Ile Gln Gly Leu Ser Phe Val 
        195                 200                 205             


Thr Arg Arg Arg Ile Arg Arg Thr Val Arg Arg Ala Leu Arg Arg Val 
    210                 215                 220                 


Ala Ala Cys Gln Ala Asp Arg His Ser Leu Met Ala Lys Tyr Ile Met 
225                 230                 235                 240 


Asp Leu Glu Arg Leu Asp Pro Ala Gly Ala Ala Glu Thr Phe His Val 
                245                 250                 255     


Gly Leu Pro Gly Ala Leu Gly Gly His Asp Gly Leu Gly Leu Leu Arg 
            260                 265                 270         


Val Ala Gly Asp Gly Gly Ile Ala Trp Thr Gln Gly Glu Gln Glu Val 
        275                 280                 285             


Leu Gln Pro Phe Cys Asp Phe Pro Glu Ile Val Asp Ile Ser Ile Lys 
    290                 295                 300                 


Gln Ala Pro Arg Val Gly Pro Ala Gly Glu His Arg Leu Val Thr Val 
305                 310                 315                 320 


Thr Arg Thr Asp Asn Gln Ile Leu Glu Ala Glu Phe Pro Gly Leu Pro 
                325                 330                 335     


Glu Ala Leu Ser Phe Val Ala Leu Val Asp Gly Tyr Phe Arg Leu Thr 
            340                 345                 350         


Thr Asp Ser Gln His Phe Phe Cys Lys Glu Val Ala Pro Pro Arg Leu 
        355                 360                 365             


Leu Glu Glu Val Ala Glu Gln Cys His Gly Pro Ile Thr Leu Asp Phe 
    370                 375                 380                 


Ala Ile Asn Lys Leu Lys Thr Gly Gly Ser Arg Pro Gly Ser Tyr Val 
385                 390                 395                 400 


Leu Arg Arg Ser Pro Gln Asp Phe Asp Ser Phe Leu Leu Thr Val Cys 
                405                 410                 415     


Val Gln Asn Pro Leu Gly Pro Asp Tyr Lys Gly Cys Leu Ile Arg Arg 
            420                 425                 430         


Ser Pro Thr Gly Thr Phe Leu Leu Val Gly Leu Ser Arg Pro His Ser 
        435                 440                 445             


Ser Leu Arg Glu Leu Leu Ala Thr Cys Trp Asp Gly Gly Leu His Val 
    450                 455                 460                 


Asp Gly Val Ala Val Thr Leu Thr Ser Cys Cys Ile Pro Arg Pro Lys 
465                 470                 475                 480 


Glu Lys Ser Asn Leu Ile Val Val Gln Arg Gly His Ser Pro Pro Thr 
                485                 490                 495     


Ser Ser Leu Val Gln Pro Gln Ser Gln Tyr Gln Leu Ser Gln Met Thr 
            500                 505                 510         


Phe His Lys Ile Pro Ala Asp Ser Leu Glu Trp His Glu Asn Leu Gly 
        515                 520                 525             


His Gly Ser Phe Thr Lys Ile Tyr Arg Gly Cys Arg His Glu Val Val 
    530                 535                 540                 


Asp Gly Glu Ala Arg Lys Thr Glu Val Leu Leu Lys Val Met Asp Ala 
545                 550                 555                 560 


Lys His Lys Asn Cys Met Glu Ser Phe Leu Glu Ala Ala Ser Leu Met 
                565                 570                 575     


Ser Gln Val Ser Tyr Arg His Leu Val Leu Leu His Gly Val Cys Met 
            580                 585                 590         


Ala Gly Asp Ser Thr Met Val Gln Glu Phe Val His Leu Gly Ala Ile 
        595                 600                 605             


Asp Met Tyr Leu Arg Lys Arg Gly His Leu Val Pro Ala Ser Trp Lys 
    610                 615                 620                 


Leu Gln Val Val Lys Gln Leu Ala Tyr Ala Leu Asn Tyr Leu Glu Asp 
625                 630                 635                 640 


Lys Gly Leu Pro His Gly Asn Val Ser Ala Arg Lys Val Leu Leu Ala 
                645                 650                 655     


Arg Glu Gly Ala Asp Gly Ser Pro Pro Phe Ile Lys Leu Ser Asp Pro 
            660                 665                 670         


Gly Val Ser Pro Ala Val Leu Ser Leu Glu Met Leu Thr Asp Arg Ile 
        675                 680                 685             


Pro Trp Val Ala Pro Glu Cys Leu Arg Glu Ala Gln Thr Leu Ser Leu 
    690                 695                 700                 


Glu Ala Asp Lys Trp Gly Phe Gly Ala Thr Val Trp Glu Val Phe Ser 
705                 710                 715                 720 


Gly Val Thr Met Pro Ile Ser Ala Leu Asp Pro Ala Lys Lys Leu Gln 
                725                 730                 735     


Phe Tyr Glu Asp Arg Gln Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu 
            740                 745                 750         


Ala Leu Leu Ile Gln Gln Cys Met Ala Tyr Glu Pro Val Gln Arg Pro 
        755                 760                 765             


Ser Phe Arg Ala Val Ile Arg Asp Leu Asn Ser Leu Ile Ser Ser Asp 
    770                 775                 780                 


Tyr Glu Leu Leu Ser Asp Pro Thr Pro Gly Ala Leu Ala Pro Arg Asp 
785                 790                 795                 800 


Gly Leu Trp Asn Gly Ala Gln Leu Tyr Ala Cys Gln Asp Pro Thr Ile 
                805                 810                 815     


Phe Glu Glu Arg His Leu Lys Tyr Ile Ser Gln Leu Gly Lys Gly Asn 
            820                 825                 830         


Phe Gly Ser Val Glu Leu Cys Arg Tyr Asp Pro Leu Gly Asp Asn Thr 
        835                 840                 845             


Gly Ala Leu Val Ala Val Lys Gln Leu Gln His Ser Gly Pro Asp Gln 
    850                 855                 860                 


Gln Arg Asp Phe Gln Arg Glu Ile Gln Ile Leu Lys Ala Leu His Ser 
865                 870                 875                 880 


Asp Phe Ile Val Lys Tyr Arg Gly Val Ser Tyr Gly Pro Gly Arg Gln 
                885                 890                 895     


Ser Leu Arg Leu Val Met Glu Tyr Leu Pro Ser Gly Cys Leu Arg Asp 
            900                 905                 910         


Phe Leu Gln Arg His Arg Ala Arg Leu Asp Ala Ser Arg Leu Leu Leu 
        915                 920                 925             


Tyr Ser Ser Gln Ile Cys Lys Gly Met Glu Tyr Leu Gly Ser Arg Arg 
    930                 935                 940                 


Cys Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Glu Ser Glu 
945                 950                 955                 960 


Ala His Val Lys Ile Ala Asp Phe Gly Leu Ala Lys Leu Leu Pro Leu 
                965                 970                 975     


Asp Lys Asp Tyr Tyr Val Val Arg Glu Pro Gly Gln Ser Pro Ile Phe 
            980                 985                 990         


Trp Tyr Ala Pro Glu Ser Leu Ser  Asp Asn Ile Phe Ser  Arg Gln Ser 
        995                 1000                 1005             


Asp Val  Trp Ser Phe Gly Val  Val Leu Tyr Glu Leu  Phe Thr Tyr 
    1010                 1015                 1020             


Cys Asp  Lys Ser Cys Ser Pro  Ser Ala Glu Phe Leu  Arg Met Met 
    1025                 1030                 1035             


Gly Cys  Glu Arg Asp Val Pro  Ala Leu Cys Arg Leu  Leu Glu Leu 
    1040                 1045                 1050             


Leu Glu  Glu Gly Gln Arg Leu  Pro Ala Pro Pro Ala  Cys Pro Ala 
    1055                 1060                 1065             


Glu Val  His Glu Leu Met Lys  Leu Cys Trp Ala Pro  Ser Pro Gln 
    1070                 1075                 1080             


Asp Arg  Pro Ser Phe Ser Ala  Leu Gly Pro Gln Leu  Asp Met Leu 
    1085                 1090                 1095             


Trp Ser  Gly Ser Arg Gly Cys  Glu Thr His Ala Phe  Thr Ala His 
    1100                 1105                 1110             


Pro Glu  Gly Lys His His Ser  Leu Ser Phe Ser 
    1115                 1120                 


<210>  7
<211>  3564
<212>  DNA
<213>  Homo sapiens

<400>  7
atgcctctgc gccactgggg gatggccagg ggcagtaagc ccgttgggga tggagcccag       60

cccatggctg ccatgggagg cctgaaggtg cttctgcact gggctggtcc aggcggcggg      120

gagccctggg tcactttcag tgagtcatcg ctgacagctg aggaagtctg catccacatt      180

gcacataaag ttggtatcac tcctccttgc ttcaatctct ttgccctctt cgatgctcag      240

gcccaagtct ggttgccccc aaaccacatc ctagagatcc ccagagatgc aagcctgatg      300

ctatatttcc gcataaggtt ttatttccgg aactggcatg gcatgaatcc tcgggaaccg      360

gctgtgtacc gttgtgggcc cccaggaacc gaggcatcct cagatcagac agcacagggg      420

atgcaactcc tggacccagc ctcatttgag tacctctttg agcagggcaa gcatgagttt      480

gtgaatgacg tggcatcact gtgggagctg tcgaccgagg aggagatcca ccactttaag      540

aatgagagcc tgggcatggc ctttctgcac ctctgtcacc tcgctctccg ccatggcatc      600

cccctggagg aggtggccaa gaagaccagc ttcaaggact gcatcccgcg ctccttccgc      660

cggcatatcc ggcagcacag cgccctgacc cggctgcgcc ttcggaacgt cttccgcagg      720

ttcctgcggg acttccagcc gggccgactc tcccagcaga tggtcatggt caaataccta      780

gccacactcg agcggctggc accccgcttc ggcacagagc gtgtgcccgt gtgccacctg      840

aggctgctgg cccaggccga gggggagccc tgctacatcc gggacagtgg ggtggcccct      900

acagaccctg gccctgagtc tgctgctggg cccccaaccc acgaggtgct ggtgacaggc      960

actggtggca tccagtggtg gccagtagag gaggaggtga acaaggagga gggttctagt     1020

ggcagcagtg gcaggaaccc ccaagccagc ctgtttggga agaaggccaa ggctcacaag     1080

gcagtcggcc agccggcaga caggccgcgg gagccactgt gggcctactt ctgtgacttc     1140

cgggacatca cccacgtggt gctgaaagag cactgtgtca gcatccaccg gcaggacaac     1200

aagtgcctgg agctgagctt gccttcccgg gctgcggcgc tgtccttcgt gtcgctggtg     1260

gacggctatt tccgcctgac ggccgactcc agccactacc tgtgccacga ggtggctccc     1320

ccacggctgg tgatgagcat ccgggatggg atccacggac ccctgctgga gccatttgtg     1380

caggccaagc tgcggcccga ggacggcctg tacctcattc actggagcac cagccacccc     1440

taccgcctga tcctcacagt ggcccagcgt agccaggcac cagacggcat gcagagcttg     1500

cggctccgaa agttccccat tgagcagcag gacggggcct tcgtgctgga gggctggggc     1560

cggtccttcc ccagcgttcg ggaacttggg gctgccttgc agggctgctt gctgagggcc     1620

ggggatgact gcttctctct gcgtcgctgt tgcctgcccc aaccaggaga aacctccaat     1680

ctcatcatca tgcggggggc tcgggccagc cccaggacac tcaacctcag ccagctcagc     1740

ttccaccggg ttgaccagaa ggagatcacc cagctgtccc acttgggcca gggcacaagg     1800

accaacgtgt atgagggccg cctgcgagtg gagggcagcg gggaccctga ggagggcaag     1860

atggatgacg aggaccccct cgtgcctggc agggaccgtg ggcaggagct acgagtggtg     1920

ctcaaagtgc tggaccctag tcaccatgac atcgccctgg ccttctacga gacagccagc     1980

ctcatgagcc aggtctccca cacgcacctg gccttcgtgc atggcgtctg tgtgcgcggc     2040

cctgaaaata tcatggtgac agagtacgtg gagcacggac ccctggatgt gtggctgcgg     2100

agggagcggg gccatgtgcc catggcttgg aagatggtgg tggcccagca gctggccagc     2160

gccctcagct acctggagaa caagaacctg gttcatggta atgtgtgtgg ccggaacatc     2220

ctgctggccc ggctggggtt ggcagagggc accagcccct tcatcaagct gagtgatcct     2280

ggcgtgggcc tgggcgccct ctccagggag gagcgggtgg agaggatccc ctggctggcc     2340

cccgaatgcc taccaggtgg ggccaacagc ctaagcaccg ccatggacaa gtgggggttt     2400

ggcgccaccc tcctggagat ctgctttgac ggagaggccc ctctgcagag ccgcagtccc     2460

tccgagaagg agcatttcta ccagaggcag caccggctgc ccgagccctc ctgcccacag     2520

ctggccacac tcaccagcca gtgtctgacc tatgagccaa cccagaggcc atcattccgc     2580

accatcctgc gtgacctcac ccggctgcag ccccacaatc ttgctgacgt cttgactgtg     2640

aacccggact caccggcgtc ggaccctacg gttttccaca agcgctattt gaaaaagatc     2700

cgagatctgg gcgagggtca cttcggcaag gtcagcttgt actgctacga tccgaccaac     2760

gacggcactg gcgagatggt ggcggtgaaa gccctcaagg cagactgcgg cccccagcac     2820

cgctcgggct ggaagcagga gattgacatt ctgcgcacgc tctaccacga gcacatcatc     2880

aagtacaagg gctgctgcga ggaccaaggc gagaagtcgc tgcagctggt catggagtac     2940

gtgcccctgg gcagcctccg agactacctg ccccggcaca gcatcgggct ggcccagctg     3000

ctgctcttcg cccagcagat ctgcgagggc atggcctatc tgcacgcgca gcactacatc     3060

caccgagacc tagccgcgcg caacgtgctg ctggacaacg acaggctggt caagatcggg     3120

gactttggcc tagccaaggc cgtgcccgaa ggccacgagt actaccgcgt gcgcgaggat     3180

ggggacagcc ccgtgttctg gtatgcccca gagtgcctga aggagtataa gttctactat     3240

gcgtcagatg tctggtcctt cggggtgacc ctgtatgagc tgctgacgca ctgtgactcc     3300

agccagagcc cccccacgaa attccttgag ctcataggca ttgctcaggg tcagatgaca     3360

gttctgagac tcactgagtt gctggaacga ggggagaggc tgccacggcc cgacaaatgt     3420

ccctgtgagg tctatcatct catgaagaac tgctgggaga cagaggcgtc ctttcgccca     3480

accttcgaga acctcatacc cattctgaag acagtccatg agaagtacca aggccaggcc     3540

ccttcagtgt tcagcgtgtg ctga                                            3564


<210>  8
<211>  1187
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Leu Arg His Trp Gly Met Ala Arg Gly Ser Lys Pro Val Gly 
1               5                   10                  15      


Asp Gly Ala Gln Pro Met Ala Ala Met Gly Gly Leu Lys Val Leu Leu 
            20                  25                  30          


His Trp Ala Gly Pro Gly Gly Gly Glu Pro Trp Val Thr Phe Ser Glu 
        35                  40                  45              


Ser Ser Leu Thr Ala Glu Glu Val Cys Ile His Ile Ala His Lys Val 
    50                  55                  60                  


Gly Ile Thr Pro Pro Cys Phe Asn Leu Phe Ala Leu Phe Asp Ala Gln 
65                  70                  75                  80  


Ala Gln Val Trp Leu Pro Pro Asn His Ile Leu Glu Ile Pro Arg Asp 
                85                  90                  95      


Ala Ser Leu Met Leu Tyr Phe Arg Ile Arg Phe Tyr Phe Arg Asn Trp 
            100                 105                 110         


His Gly Met Asn Pro Arg Glu Pro Ala Val Tyr Arg Cys Gly Pro Pro 
        115                 120                 125             


Gly Thr Glu Ala Ser Ser Asp Gln Thr Ala Gln Gly Met Gln Leu Leu 
    130                 135                 140                 


Asp Pro Ala Ser Phe Glu Tyr Leu Phe Glu Gln Gly Lys His Glu Phe 
145                 150                 155                 160 


Val Asn Asp Val Ala Ser Leu Trp Glu Leu Ser Thr Glu Glu Glu Ile 
                165                 170                 175     


His His Phe Lys Asn Glu Ser Leu Gly Met Ala Phe Leu His Leu Cys 
            180                 185                 190         


His Leu Ala Leu Arg His Gly Ile Pro Leu Glu Glu Val Ala Lys Lys 
        195                 200                 205             


Thr Ser Phe Lys Asp Cys Ile Pro Arg Ser Phe Arg Arg His Ile Arg 
    210                 215                 220                 


Gln His Ser Ala Leu Thr Arg Leu Arg Leu Arg Asn Val Phe Arg Arg 
225                 230                 235                 240 


Phe Leu Arg Asp Phe Gln Pro Gly Arg Leu Ser Gln Gln Met Val Met 
                245                 250                 255     


Val Lys Tyr Leu Ala Thr Leu Glu Arg Leu Ala Pro Arg Phe Gly Thr 
            260                 265                 270         


Glu Arg Val Pro Val Cys His Leu Arg Leu Leu Ala Gln Ala Glu Gly 
        275                 280                 285             


Glu Pro Cys Tyr Ile Arg Asp Ser Gly Val Ala Pro Thr Asp Pro Gly 
    290                 295                 300                 


Pro Glu Ser Ala Ala Gly Pro Pro Thr His Glu Val Leu Val Thr Gly 
305                 310                 315                 320 


Thr Gly Gly Ile Gln Trp Trp Pro Val Glu Glu Glu Val Asn Lys Glu 
                325                 330                 335     


Glu Gly Ser Ser Gly Ser Ser Gly Arg Asn Pro Gln Ala Ser Leu Phe 
            340                 345                 350         


Gly Lys Lys Ala Lys Ala His Lys Ala Val Gly Gln Pro Ala Asp Arg 
        355                 360                 365             


Pro Arg Glu Pro Leu Trp Ala Tyr Phe Cys Asp Phe Arg Asp Ile Thr 
    370                 375                 380                 


His Val Val Leu Lys Glu His Cys Val Ser Ile His Arg Gln Asp Asn 
385                 390                 395                 400 


Lys Cys Leu Glu Leu Ser Leu Pro Ser Arg Ala Ala Ala Leu Ser Phe 
                405                 410                 415     


Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr Ala Asp Ser Ser His 
            420                 425                 430         


Tyr Leu Cys His Glu Val Ala Pro Pro Arg Leu Val Met Ser Ile Arg 
        435                 440                 445             


Asp Gly Ile His Gly Pro Leu Leu Glu Pro Phe Val Gln Ala Lys Leu 
    450                 455                 460                 


Arg Pro Glu Asp Gly Leu Tyr Leu Ile His Trp Ser Thr Ser His Pro 
465                 470                 475                 480 


Tyr Arg Leu Ile Leu Thr Val Ala Gln Arg Ser Gln Ala Pro Asp Gly 
                485                 490                 495     


Met Gln Ser Leu Arg Leu Arg Lys Phe Pro Ile Glu Gln Gln Asp Gly 
            500                 505                 510         


Ala Phe Val Leu Glu Gly Trp Gly Arg Ser Phe Pro Ser Val Arg Glu 
        515                 520                 525             


Leu Gly Ala Ala Leu Gln Gly Cys Leu Leu Arg Ala Gly Asp Asp Cys 
    530                 535                 540                 


Phe Ser Leu Arg Arg Cys Cys Leu Pro Gln Pro Gly Glu Thr Ser Asn 
545                 550                 555                 560 


Leu Ile Ile Met Arg Gly Ala Arg Ala Ser Pro Arg Thr Leu Asn Leu 
                565                 570                 575     


Ser Gln Leu Ser Phe His Arg Val Asp Gln Lys Glu Ile Thr Gln Leu 
            580                 585                 590         


Ser His Leu Gly Gln Gly Thr Arg Thr Asn Val Tyr Glu Gly Arg Leu 
        595                 600                 605             


Arg Val Glu Gly Ser Gly Asp Pro Glu Glu Gly Lys Met Asp Asp Glu 
    610                 615                 620                 


Asp Pro Leu Val Pro Gly Arg Asp Arg Gly Gln Glu Leu Arg Val Val 
625                 630                 635                 640 


Leu Lys Val Leu Asp Pro Ser His His Asp Ile Ala Leu Ala Phe Tyr 
                645                 650                 655     


Glu Thr Ala Ser Leu Met Ser Gln Val Ser His Thr His Leu Ala Phe 
            660                 665                 670         


Val His Gly Val Cys Val Arg Gly Pro Glu Asn Ile Met Val Thr Glu 
        675                 680                 685             


Tyr Val Glu His Gly Pro Leu Asp Val Trp Leu Arg Arg Glu Arg Gly 
    690                 695                 700                 


His Val Pro Met Ala Trp Lys Met Val Val Ala Gln Gln Leu Ala Ser 
705                 710                 715                 720 


Ala Leu Ser Tyr Leu Glu Asn Lys Asn Leu Val His Gly Asn Val Cys 
                725                 730                 735     


Gly Arg Asn Ile Leu Leu Ala Arg Leu Gly Leu Ala Glu Gly Thr Ser 
            740                 745                 750         


Pro Phe Ile Lys Leu Ser Asp Pro Gly Val Gly Leu Gly Ala Leu Ser 
        755                 760                 765             


Arg Glu Glu Arg Val Glu Arg Ile Pro Trp Leu Ala Pro Glu Cys Leu 
    770                 775                 780                 


Pro Gly Gly Ala Asn Ser Leu Ser Thr Ala Met Asp Lys Trp Gly Phe 
785                 790                 795                 800 


Gly Ala Thr Leu Leu Glu Ile Cys Phe Asp Gly Glu Ala Pro Leu Gln 
                805                 810                 815     


Ser Arg Ser Pro Ser Glu Lys Glu His Phe Tyr Gln Arg Gln His Arg 
            820                 825                 830         


Leu Pro Glu Pro Ser Cys Pro Gln Leu Ala Thr Leu Thr Ser Gln Cys 
        835                 840                 845             


Leu Thr Tyr Glu Pro Thr Gln Arg Pro Ser Phe Arg Thr Ile Leu Arg 
    850                 855                 860                 


Asp Leu Thr Arg Leu Gln Pro His Asn Leu Ala Asp Val Leu Thr Val 
865                 870                 875                 880 


Asn Pro Asp Ser Pro Ala Ser Asp Pro Thr Val Phe His Lys Arg Tyr 
                885                 890                 895     


Leu Lys Lys Ile Arg Asp Leu Gly Glu Gly His Phe Gly Lys Val Ser 
            900                 905                 910         


Leu Tyr Cys Tyr Asp Pro Thr Asn Asp Gly Thr Gly Glu Met Val Ala 
        915                 920                 925             


Val Lys Ala Leu Lys Ala Asp Cys Gly Pro Gln His Arg Ser Gly Trp 
    930                 935                 940                 


Lys Gln Glu Ile Asp Ile Leu Arg Thr Leu Tyr His Glu His Ile Ile 
945                 950                 955                 960 


Lys Tyr Lys Gly Cys Cys Glu Asp Gln Gly Glu Lys Ser Leu Gln Leu 
                965                 970                 975     


Val Met Glu Tyr Val Pro Leu Gly Ser Leu Arg Asp Tyr Leu Pro Arg 
            980                 985                 990         


His Ser Ile Gly Leu Ala Gln Leu  Leu Leu Phe Ala Gln  Gln Ile Cys 
        995                 1000                 1005             


Glu Gly  Met Ala Tyr Leu His  Ala Gln His Tyr Ile  His Arg Asp 
    1010                 1015                 1020             


Leu Ala  Ala Arg Asn Val Leu  Leu Asp Asn Asp Arg  Leu Val Lys 
    1025                 1030                 1035             


Ile Gly  Asp Phe Gly Leu Ala  Lys Ala Val Pro Glu  Gly His Glu 
    1040                 1045                 1050             


Tyr Tyr  Arg Val Arg Glu Asp  Gly Asp Ser Pro Val  Phe Trp Tyr 
    1055                 1060                 1065             


Ala Pro  Glu Cys Leu Lys Glu  Tyr Lys Phe Tyr Tyr  Ala Ser Asp 
    1070                 1075                 1080             


Val Trp  Ser Phe Gly Val Thr  Leu Tyr Glu Leu Leu  Thr His Cys 
    1085                 1090                 1095             


Asp Ser  Ser Gln Ser Pro Pro  Thr Lys Phe Leu Glu  Leu Ile Gly 
    1100                 1105                 1110             


Ile Ala  Gln Gly Gln Met Thr  Val Leu Arg Leu Thr  Glu Leu Leu 
    1115                 1120                 1125             


Glu Arg  Gly Glu Arg Leu Pro  Arg Pro Asp Lys Cys  Pro Cys Glu 
    1130                 1135                 1140             


Val Tyr  His Leu Met Lys Asn  Cys Trp Glu Thr Glu  Ala Ser Phe 
    1145                 1150                 1155             


Arg Pro  Thr Phe Glu Asn Leu  Ile Pro Ile Leu Lys  Thr Val His 
    1160                 1165                 1170             


Glu Lys  Tyr Gln Gly Gln Ala  Pro Ser Val Phe Ser  Val Cys 
    1175                 1180                 1185         


<210>  9
<211>  1956
<212>  DNA
<213>  Homo sapiens

<400>  9
atggcggaca gtgcggaact aaagcaaatg gttatgagcc ttagagtttc tgaactccaa       60

gtactgttgg gctacgccgg gagaaacaag cacggacgca aacacgaact tctcacaaaa      120

gccctgcatt tgctaaaggc tggctgtagt cctgctgtgc aaatgaaaat taaggaactc      180

tataggcggc ggttcccaca gaaaatcatg acgcctgcag acttgtccat ccccaacgta      240

cattcaagtc ctatgccagc aactttgtct ccatctacca ttccacaact cacttacgat      300

ggtcaccctg catcatcgcc attactccct gtttctcttc tgggacctaa acatgaactg      360

gaactcccac atcttacatc agctcttcac ccagtccatc cggatataaa acttcaaaaa      420

ttaccatttt atgatttact ggatgaactg ataaaaccca ccagtctagc atcagacaac      480

agtcagcgct ttcgagaaac ctgttttgca tttgccttga caccacaaca agtgcagcaa      540

atcagtagtt ccatggatat ttctgggacc aaatgtgact tcacagtaca ggtccagtta      600

aggttttgtt tatcagaaac cagttgtcca caagaagatc acttcccacc caatctttgt      660

gtgaaagtga atacaaaacc ttgcagcctt ccaggttacc ttccacctac aaaaaatggc      720

gtggaaccaa agcgacccag ccgaccaatt aatatcacct cacttgtccg actgtccaca      780

acagtaccaa acacgattgt tgtttcttgg actgcagaaa ttggaagaaa ctattccatg      840

gcagtatatc ttgtaaaaca gttgtcctca acagttcttc ttcagaggtt acgagcaaag      900

ggaataagga atccggatca ttctagagct ttaattaaag agaagttgac tgcggatcca      960

gacagtgaaa tagctacaac cagcctaagg gtttctctac tatgtccact tggtaaaatg     1020

cggctgacaa ttccgtgtcg ggcccttaca tgttctcatc tacaatgttt tgacgcaact     1080

ctttacattc agatgaatga gaaaaaacca acctgggttt gtcctgtctg tgataagaag     1140

gctccatatg aacaccttat tattgatggc ttgtttatgg aaatcctaaa gtactgtaca     1200

gactgtgatg aaatacaatt taaggaggat ggcacttggg caccgatgag atcaaaaaag     1260

gaagtacagg aagtttctgc ctcttacaat ggagtcgatg gatgcttgag ctccacattg     1320

gagcatcagg tagcgtctca ccaccagtcc tcaaataaaa acaagaaagt agaagtgatt     1380

gacctaacca tagacagttc atctgatgaa gaggaagaag agccatctgc caagaggacc     1440

tgtccttccc tatctcccac atcaccacta aataataaag gcattttaag tcttccacat     1500

caagcatctc cagtatcccg caccccaagc cttcctgctg tagacacaag ctacattaat     1560

acctccctca tccaagacta taggcatcct ttccacatga cacccatgcc ttacgactta     1620

caaggattag atttctttcc tttcttatca ggagacaatc agcattacaa cacctccttg     1680

cttgccgctg cagcagcagc agtttcagat gatcaagacc tcctacactc gtctcggttt     1740

ttcccgtata cctcctcaca gatgtttctt gatcagttaa gtgcaggagg cagtacttct     1800

ctgccaacca ccaatggaag cagtagtggc agtaacagca gcctggtttc ttccaacagc     1860

ctaagggaaa gccatagcca caccgtcaca aacaggagca gcacggacac ggcatccatc     1920

tttggcatca taccagacat tatttcattg gactga                               1956


<210>  10
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Asp Ser Ala Glu Leu Lys Gln Met Val Met Ser Leu Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Tyr Ala Gly Arg Asn Lys His Gly 
            20                  25                  30          


Arg Lys His Glu Leu Leu Thr Lys Ala Leu His Leu Leu Lys Ala Gly 
        35                  40                  45              


Cys Ser Pro Ala Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Phe Pro Gln Lys Ile Met Thr Pro Ala Asp Leu Ser Ile Pro Asn Val 
65                  70                  75                  80  


His Ser Ser Pro Met Pro Ala Thr Leu Ser Pro Ser Thr Ile Pro Gln 
                85                  90                  95      


Leu Thr Tyr Asp Gly His Pro Ala Ser Ser Pro Leu Leu Pro Val Ser 
            100                 105                 110         


Leu Leu Gly Pro Lys His Glu Leu Glu Leu Pro His Leu Thr Ser Ala 
        115                 120                 125             


Leu His Pro Val His Pro Asp Ile Lys Leu Gln Lys Leu Pro Phe Tyr 
    130                 135                 140                 


Asp Leu Leu Asp Glu Leu Ile Lys Pro Thr Ser Leu Ala Ser Asp Asn 
145                 150                 155                 160 


Ser Gln Arg Phe Arg Glu Thr Cys Phe Ala Phe Ala Leu Thr Pro Gln 
                165                 170                 175     


Gln Val Gln Gln Ile Ser Ser Ser Met Asp Ile Ser Gly Thr Lys Cys 
            180                 185                 190         


Asp Phe Thr Val Gln Val Gln Leu Arg Phe Cys Leu Ser Glu Thr Ser 
        195                 200                 205             


Cys Pro Gln Glu Asp His Phe Pro Pro Asn Leu Cys Val Lys Val Asn 
    210                 215                 220                 


Thr Lys Pro Cys Ser Leu Pro Gly Tyr Leu Pro Pro Thr Lys Asn Gly 
225                 230                 235                 240 


Val Glu Pro Lys Arg Pro Ser Arg Pro Ile Asn Ile Thr Ser Leu Val 
                245                 250                 255     


Arg Leu Ser Thr Thr Val Pro Asn Thr Ile Val Val Ser Trp Thr Ala 
            260                 265                 270         


Glu Ile Gly Arg Asn Tyr Ser Met Ala Val Tyr Leu Val Lys Gln Leu 
        275                 280                 285             


Ser Ser Thr Val Leu Leu Gln Arg Leu Arg Ala Lys Gly Ile Arg Asn 
    290                 295                 300                 


Pro Asp His Ser Arg Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro 
305                 310                 315                 320 


Asp Ser Glu Ile Ala Thr Thr Ser Leu Arg Val Ser Leu Leu Cys Pro 
                325                 330                 335     


Leu Gly Lys Met Arg Leu Thr Ile Pro Cys Arg Ala Leu Thr Cys Ser 
            340                 345                 350         


His Leu Gln Cys Phe Asp Ala Thr Leu Tyr Ile Gln Met Asn Glu Lys 
        355                 360                 365             


Lys Pro Thr Trp Val Cys Pro Val Cys Asp Lys Lys Ala Pro Tyr Glu 
    370                 375                 380                 


His Leu Ile Ile Asp Gly Leu Phe Met Glu Ile Leu Lys Tyr Cys Thr 
385                 390                 395                 400 


Asp Cys Asp Glu Ile Gln Phe Lys Glu Asp Gly Thr Trp Ala Pro Met 
                405                 410                 415     


Arg Ser Lys Lys Glu Val Gln Glu Val Ser Ala Ser Tyr Asn Gly Val 
            420                 425                 430         


Asp Gly Cys Leu Ser Ser Thr Leu Glu His Gln Val Ala Ser His His 
        435                 440                 445             


Gln Ser Ser Asn Lys Asn Lys Lys Val Glu Val Ile Asp Leu Thr Ile 
    450                 455                 460                 


Asp Ser Ser Ser Asp Glu Glu Glu Glu Glu Pro Ser Ala Lys Arg Thr 
465                 470                 475                 480 


Cys Pro Ser Leu Ser Pro Thr Ser Pro Leu Asn Asn Lys Gly Ile Leu 
                485                 490                 495     


Ser Leu Pro His Gln Ala Ser Pro Val Ser Arg Thr Pro Ser Leu Pro 
            500                 505                 510         


Ala Val Asp Thr Ser Tyr Ile Asn Thr Ser Leu Ile Gln Asp Tyr Arg 
        515                 520                 525             


His Pro Phe His Met Thr Pro Met Pro Tyr Asp Leu Gln Gly Leu Asp 
    530                 535                 540                 


Phe Phe Pro Phe Leu Ser Gly Asp Asn Gln His Tyr Asn Thr Ser Leu 
545                 550                 555                 560 


Leu Ala Ala Ala Ala Ala Ala Val Ser Asp Asp Gln Asp Leu Leu His 
                565                 570                 575     


Ser Ser Arg Phe Phe Pro Tyr Thr Ser Ser Gln Met Phe Leu Asp Gln 
            580                 585                 590         


Leu Ser Ala Gly Gly Ser Thr Ser Leu Pro Thr Thr Asn Gly Ser Ser 
        595                 600                 605             


Ser Gly Ser Asn Ser Ser Leu Val Ser Ser Asn Ser Leu Arg Glu Ser 
    610                 615                 620                 


His Ser His Thr Val Thr Asn Arg Ser Ser Thr Asp Thr Ala Ser Ile 
625                 630                 635                 640 


Phe Gly Ile Ile Pro Asp Ile Ile Ser Leu Asp 
                645                 650     


<210>  11
<211>  1719
<212>  DNA
<213>  Homo sapiens

<400>  11
atggcggatt tcgaagagtt gaggaatatg gtttctagtt ttagggtttc tgaactacaa       60

gtattactag gctttgctgg acggaataaa agtggacgca agcatgacct cctgatgagg      120

gcgctgcatt tattgaagag cggctgcagc cctgcggttc agattaaaat ccgagaattg      180

tatagacgcc gatatccacg aactcttgaa ggactttctg atttatccac aatcaaatca      240

tcggttttca gtttggatgg tggctcatca cctgtagaac ctgacttggc cgtggctgga      300

atccactcgt tgccttccac ttcagttaca cctcactcac catcctctcc tgttggttct      360

gtgctgcttc aagatactaa gcccacattt gagatgcagc agccatctcc cccaattcct      420

cctgtccatc ctgatgtgca gttaaaaaat ctgccctttt atgatgtcct tgatgttctc      480

atcaagccca cgagtttagt tcaaagcagt attcagcgat ttcaagagaa gttttttatt      540

tttgctttga cacctcaaca agttagagag atatgcatat ccagggattt tttgccaggt      600

ggtaggagag attatacagt ccaagttcag ttgagacttt gcctggcaga gacaagttgc      660

cctcaagaag ataactatcc aaatagtcta tgtataaaag taaatgggaa gctatttcct      720

ttgcctggct atgcaccacc gcctaaaaat gggattgaac agaagcgccc tggacgcccc      780

ttgaatatta catctttagt taggttatct tcagctgtgc caaaccaaat ttccatttct      840

tgggcatcag aaattgggaa gaattactct atgtctgtat atcttgtacg gcagcttaca      900

tcagccatgt tattacagag attaaaaatg aaaggtatta gaaaccctga tcattccaga      960

gcactaatta aagaaaaact tactgcagat cctgatagtg aaattgctac aactagcctt     1020

cgggtatcct tgatgtgccc tttaggaaaa atgaggctga caatcccatg ccgtgcagtg     1080

acttgtacac atctgcagtg ttttgatgct gccctctatc tacaaatgaa tgagaaaaag     1140

cccacctgga tttgtcctgt gtgtgacaaa aaagctgcct atgaaagtct aatattagat     1200

gggcttttta tggaaattct caatgactgt tctgatgtag atgagatcaa attccaagaa     1260

gatggttctt ggtgtccaat gagaccgaag aaagaagcta tgaaagtatc cagccaaccg     1320

tgtacaaaaa tagaaagttc aagcgtcctc agtaagcctt gttcagtgac tgtagccagt     1380

gaggcaagca agaagaaagt agatgttatt gatcttacaa tagaaagctc ttctgacgaa     1440

gaggaagacc ctcctgccaa aaggaaatgc atctttatgt cagaaacaca aagcagccca     1500

accaaagggg ttctcatgta tcagccatct tctgtaaggg tgcccagtgt gacttcggtt     1560

gatcctgctg ctattccgcc ttcattaaca gactactcag taccattcca ccatacgcca     1620

atatcaagca tgtcatcaga tttgccagga gaacaaagaa gaaatgatat taataatgaa     1680

ctgaagcttg gaacatcttc tgatactgtg caacagtga                            1719


<210>  12
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Asp Phe Glu Glu Leu Arg Asn Met Val Ser Ser Phe Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Phe Ala Gly Arg Asn Lys Ser Gly 
            20                  25                  30          


Arg Lys His Asp Leu Leu Met Arg Ala Leu His Leu Leu Lys Ser Gly 
        35                  40                  45              


Cys Ser Pro Ala Val Gln Ile Lys Ile Arg Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Tyr Pro Arg Thr Leu Glu Gly Leu Ser Asp Leu Ser Thr Ile Lys Ser 
65                  70                  75                  80  


Ser Val Phe Ser Leu Asp Gly Gly Ser Ser Pro Val Glu Pro Asp Leu 
                85                  90                  95      


Ala Val Ala Gly Ile His Ser Leu Pro Ser Thr Ser Val Thr Pro His 
            100                 105                 110         


Ser Pro Ser Ser Pro Val Gly Ser Val Leu Leu Gln Asp Thr Lys Pro 
        115                 120                 125             


Thr Phe Glu Met Gln Gln Pro Ser Pro Pro Ile Pro Pro Val His Pro 
    130                 135                 140                 


Asp Val Gln Leu Lys Asn Leu Pro Phe Tyr Asp Val Leu Asp Val Leu 
145                 150                 155                 160 


Ile Lys Pro Thr Ser Leu Val Gln Ser Ser Ile Gln Arg Phe Gln Glu 
                165                 170                 175     


Lys Phe Phe Ile Phe Ala Leu Thr Pro Gln Gln Val Arg Glu Ile Cys 
            180                 185                 190         


Ile Ser Arg Asp Phe Leu Pro Gly Gly Arg Arg Asp Tyr Thr Val Gln 
        195                 200                 205             


Val Gln Leu Arg Leu Cys Leu Ala Glu Thr Ser Cys Pro Gln Glu Asp 
    210                 215                 220                 


Asn Tyr Pro Asn Ser Leu Cys Ile Lys Val Asn Gly Lys Leu Phe Pro 
225                 230                 235                 240 


Leu Pro Gly Tyr Ala Pro Pro Pro Lys Asn Gly Ile Glu Gln Lys Arg 
                245                 250                 255     


Pro Gly Arg Pro Leu Asn Ile Thr Ser Leu Val Arg Leu Ser Ser Ala 
            260                 265                 270         


Val Pro Asn Gln Ile Ser Ile Ser Trp Ala Ser Glu Ile Gly Lys Asn 
        275                 280                 285             


Tyr Ser Met Ser Val Tyr Leu Val Arg Gln Leu Thr Ser Ala Met Leu 
    290                 295                 300                 


Leu Gln Arg Leu Lys Met Lys Gly Ile Arg Asn Pro Asp His Ser Arg 
305                 310                 315                 320 


Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Ile Ala 
                325                 330                 335     


Thr Thr Ser Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met Arg 
            340                 345                 350         


Leu Thr Ile Pro Cys Arg Ala Val Thr Cys Thr His Leu Gln Cys Phe 
        355                 360                 365             


Asp Ala Ala Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Ile 
    370                 375                 380                 


Cys Pro Val Cys Asp Lys Lys Ala Ala Tyr Glu Ser Leu Ile Leu Asp 
385                 390                 395                 400 


Gly Leu Phe Met Glu Ile Leu Asn Asp Cys Ser Asp Val Asp Glu Ile 
                405                 410                 415     


Lys Phe Gln Glu Asp Gly Ser Trp Cys Pro Met Arg Pro Lys Lys Glu 
            420                 425                 430         


Ala Met Lys Val Ser Ser Gln Pro Cys Thr Lys Ile Glu Ser Ser Ser 
        435                 440                 445             


Val Leu Ser Lys Pro Cys Ser Val Thr Val Ala Ser Glu Ala Ser Lys 
    450                 455                 460                 


Lys Lys Val Asp Val Ile Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu 
465                 470                 475                 480 


Glu Glu Asp Pro Pro Ala Lys Arg Lys Cys Ile Phe Met Ser Glu Thr 
                485                 490                 495     


Gln Ser Ser Pro Thr Lys Gly Val Leu Met Tyr Gln Pro Ser Ser Val 
            500                 505                 510         


Arg Val Pro Ser Val Thr Ser Val Asp Pro Ala Ala Ile Pro Pro Ser 
        515                 520                 525             


Leu Thr Asp Tyr Ser Val Pro Phe His His Thr Pro Ile Ser Ser Met 
    530                 535                 540                 


Ser Ser Asp Leu Pro Gly Glu Gln Arg Arg Asn Asp Ile Asn Asn Glu 
545                 550                 555                 560 


Leu Lys Leu Gly Thr Ser Ser Asp Thr Val Gln Gln 
                565                 570         


<210>  13
<211>  1866
<212>  DNA
<213>  Homo sapiens

<400>  13
atggcggatt tcgaagagtt gaggaatatg gtttctagtt ttagggtttc tgaactacaa       60

gtattactag gctttgctgg acggaataaa agtggacgca agcatgacct cctgatgagg      120

gcgctgcatt tattgaagag cggctgcagc cctgcggttc agattaaaat ccgagaattg      180

tatagacgcc gatatccacg aactcttgaa ggactttctg atttatccac aatcaaatca      240

tcggttttca gtttggatgg tggctcatca cctgtagaac ctgacttggc cgtggctgga      300

atccactcgt tgccttccac ttcagttaca cctcactcac catcctctcc tgttggttct      360

gtgctgcttc aagatactaa gcccacattt gagatgcagc agccatctcc cccaattcct      420

cctgtccatc ctgatgtgca gttaaaaaat ctgccctttt atgatgtcct tgatgttctc      480

atcaagccca cgagtttagt tcaaagcagt attcagcgat ttcaagagaa gttttttatt      540

tttgctttga cacctcaaca agttagagag atatgcatat ccagggattt tttgccaggt      600

ggtaggagag attatacagt ccaagttcag ttgagacttt gcctggcaga gacaagttgc      660

cctcaagaag ataactatcc aaatagtcta tgtataaaag taaatgggaa gctatttcct      720

ttgcctggct atgcaccacc gcctaaaaat gggattgaac agaagcgccc tggacgcccc      780

ttgaatatta catctttagt taggttatct tcagctgtgc caaaccaaat ttccatttct      840

tgggcatcag aaattgggaa gaattactct atgtctgtat atcttgtacg gcagcttaca      900

tcagccatgt tattacagag attaaaaatg aaaggtatta gaaaccctga tcattccaga      960

gcactaatta aagaaaaact tactgcagat cctgatagtg aaattgctac aactagcctt     1020

cgggtatcct tgatgtgccc tttaggaaaa atgaggctga caatcccatg ccgtgcagtg     1080

acttgtacac atctgcagtg ttttgatgct gccctctatc tacaaatgaa tgagaaaaag     1140

cccacctgga tttgtcctgt gtgtgacaaa aaagctgcct atgaaagtct aatattagat     1200

gggcttttta tggaaattct caatgactgt tctgatgtag atgagatcaa attccaagaa     1260

gatggttctt ggtgtccaat gagaccgaag aaagaagcta tgaaagtatc cagccaaccg     1320

tgtacaaaaa tagaaagttc aagcgtcctc agtaagcctt gttcagtgac tgtagccagt     1380

gaggcaagca agaagaaagt agatgttatt gatcttacaa tagaaagctc ttctgacgaa     1440

gaggaagacc ctcctgccaa aaggaaatgc atctttatgt cagaaacaca aagcagccca     1500

accaaagggg ttctcatgta tcagccatct tctgtaaggg tgcccagtgt gacttcggtt     1560

gatcctgctg ctattccgcc ttcattaaca gactactcag taccattcca ccatacgcca     1620

atatcaagca tgtcatcaga tttgccaggt ttggattttc tttcccttat tccagttgat     1680

ccccagtact gtcctcctat gtttttggat agtctcacct cacccttaac agcaagcagt     1740

acgtctgtca ccaccaccag ctcccatgaa agcagtactc atgttagttc atccagcagc     1800

aggagtgaga caggggtcat aaccagcagt ggaagtaaca ttcctgacat catctcattg     1860

gactaa                                                                1866


<210>  14
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Asp Phe Glu Glu Leu Arg Asn Met Val Ser Ser Phe Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Phe Ala Gly Arg Asn Lys Ser Gly 
            20                  25                  30          


Arg Lys His Asp Leu Leu Met Arg Ala Leu His Leu Leu Lys Ser Gly 
        35                  40                  45              


Cys Ser Pro Ala Val Gln Ile Lys Ile Arg Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Tyr Pro Arg Thr Leu Glu Gly Leu Ser Asp Leu Ser Thr Ile Lys Ser 
65                  70                  75                  80  


Ser Val Phe Ser Leu Asp Gly Gly Ser Ser Pro Val Glu Pro Asp Leu 
                85                  90                  95      


Ala Val Ala Gly Ile His Ser Leu Pro Ser Thr Ser Val Thr Pro His 
            100                 105                 110         


Ser Pro Ser Ser Pro Val Gly Ser Val Leu Leu Gln Asp Thr Lys Pro 
        115                 120                 125             


Thr Phe Glu Met Gln Gln Pro Ser Pro Pro Ile Pro Pro Val His Pro 
    130                 135                 140                 


Asp Val Gln Leu Lys Asn Leu Pro Phe Tyr Asp Val Leu Asp Val Leu 
145                 150                 155                 160 


Ile Lys Pro Thr Ser Leu Val Gln Ser Ser Ile Gln Arg Phe Gln Glu 
                165                 170                 175     


Lys Phe Phe Ile Phe Ala Leu Thr Pro Gln Gln Val Arg Glu Ile Cys 
            180                 185                 190         


Ile Ser Arg Asp Phe Leu Pro Gly Gly Arg Arg Asp Tyr Thr Val Gln 
        195                 200                 205             


Val Gln Leu Arg Leu Cys Leu Ala Glu Thr Ser Cys Pro Gln Glu Asp 
    210                 215                 220                 


Asn Tyr Pro Asn Ser Leu Cys Ile Lys Val Asn Gly Lys Leu Phe Pro 
225                 230                 235                 240 


Leu Pro Gly Tyr Ala Pro Pro Pro Lys Asn Gly Ile Glu Gln Lys Arg 
                245                 250                 255     


Pro Gly Arg Pro Leu Asn Ile Thr Ser Leu Val Arg Leu Ser Ser Ala 
            260                 265                 270         


Val Pro Asn Gln Ile Ser Ile Ser Trp Ala Ser Glu Ile Gly Lys Asn 
        275                 280                 285             


Tyr Ser Met Ser Val Tyr Leu Val Arg Gln Leu Thr Ser Ala Met Leu 
    290                 295                 300                 


Leu Gln Arg Leu Lys Met Lys Gly Ile Arg Asn Pro Asp His Ser Arg 
305                 310                 315                 320 


Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Ile Ala 
                325                 330                 335     


Thr Thr Ser Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met Arg 
            340                 345                 350         


Leu Thr Ile Pro Cys Arg Ala Val Thr Cys Thr His Leu Gln Cys Phe 
        355                 360                 365             


Asp Ala Ala Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Ile 
    370                 375                 380                 


Cys Pro Val Cys Asp Lys Lys Ala Ala Tyr Glu Ser Leu Ile Leu Asp 
385                 390                 395                 400 


Gly Leu Phe Met Glu Ile Leu Asn Asp Cys Ser Asp Val Asp Glu Ile 
                405                 410                 415     


Lys Phe Gln Glu Asp Gly Ser Trp Cys Pro Met Arg Pro Lys Lys Glu 
            420                 425                 430         


Ala Met Lys Val Ser Ser Gln Pro Cys Thr Lys Ile Glu Ser Ser Ser 
        435                 440                 445             


Val Leu Ser Lys Pro Cys Ser Val Thr Val Ala Ser Glu Ala Ser Lys 
    450                 455                 460                 


Lys Lys Val Asp Val Ile Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu 
465                 470                 475                 480 


Glu Glu Asp Pro Pro Ala Lys Arg Lys Cys Ile Phe Met Ser Glu Thr 
                485                 490                 495     


Gln Ser Ser Pro Thr Lys Gly Val Leu Met Tyr Gln Pro Ser Ser Val 
            500                 505                 510         


Arg Val Pro Ser Val Thr Ser Val Asp Pro Ala Ala Ile Pro Pro Ser 
        515                 520                 525             


Leu Thr Asp Tyr Ser Val Pro Phe His His Thr Pro Ile Ser Ser Met 
    530                 535                 540                 


Ser Ser Asp Leu Pro Gly Leu Asp Phe Leu Ser Leu Ile Pro Val Asp 
545                 550                 555                 560 


Pro Gln Tyr Cys Pro Pro Met Phe Leu Asp Ser Leu Thr Ser Pro Leu 
                565                 570                 575     


Thr Ala Ser Ser Thr Ser Val Thr Thr Thr Ser Ser His Glu Ser Ser 
            580                 585                 590         


Thr His Val Ser Ser Ser Ser Ser Arg Ser Glu Thr Gly Val Ile Thr 
        595                 600                 605             


Ser Ser Gly Ser Asn Ile Pro Asp Ile Ile Ser Leu Asp 
    610                 615                 620     


<210>  15
<211>  1887
<212>  DNA
<213>  Homo sapiens

<400>  15
atggcggagc tgggcgaatt aaagcacatg gtgatgagtt tccgggtgtc tgagctccag       60

gtgcttcttg gctttgctgg ccggaacaag agtggacgga agcacgagct cctggccaag      120

gctctgcacc tcctgaagtc cagctgtgcc cctagtgtcc agatgaagat caaagagctt      180

taccgacgac gctttccccg gaagaccctg gggccctctg atctctccct tctctctttg      240

ccccctggca cctctcctgt aggctcccct ggtcctctag ctcccattcc cccaacgctg      300

ttggcccctg gcaccctgct gggccccaag cgtgaggtgg acatgcaccc ccctctgccc      360

cagcctgtgc accctgatgt caccatgaaa ccattgccct tctatgaagt ctatggggag      420

ctcatccggc ccaccaccct tgcatccact tctagccagc ggtttgagga agcgcacttt      480

acctttgccc tcacacccca gcaagtgcag cagattctta catccagaga ggttctgcca      540

ggagccaaat gtgattatac catacaggtg cagctaaggt tctgtctctg tgagaccagc      600

tgcccccagg aagattattt tccccccaac ctctttgtca aggtcaatgg gaaactgtgc      660

cccctgccgg gttaccttcc cccaaccaag aatggggccg agcccaagag gcccagccgc      720

cccatcaaca tcacacccct ggctcgactc tcagccactg ttcccaacac cattgtggtc      780

aattggtcat ctgagttcgg acggaattac tccttgtctg tgtacctggt gaggcagttg      840

actgcaggaa cccttctaca aaaactcaga gcaaagggta tccggaaccc agaccactcg      900

cgggcactga tcaaggagaa attgactgct gaccctgaca gtgaggtggc cactacaagt      960

ctccgggtgt cactcatgtg cccgctaggg aagatgcgcc tgactgtccc ttgtcgtgcc     1020

ctcacctgcg cccacctgca gagcttcgat gctgcccttt atctacagat gaatgagaag     1080

aagcctacat ggacatgtcc tgtgtgtgac aagaaggctc cctatgaatc tcttatcatt     1140

gatggtttat ttatggagat tcttagttcc tgttcagatt gtgatgagat ccaattcatg     1200

gaagatggat cctggtgccc aatgaaaccc aagaaggagg catctgaggt ttgccccccg     1260

ccagggtatg ggctggatgg cctccagtac agcccagtcc aggggggaga tccatcagag     1320

aataagaaga aggtcgaagt tattgacttg acaatagaaa gctcatcaga tgaggaggat     1380

ctgcccccta ccaagaagca ctgttctgtc acctcagctg ccatcccggc cctacctgga     1440

agcaaaggag tcctgacatc tggccaccag ccatcctcgg tgctaaggag ccctgctatg     1500

ggcacgttgg gtggggattt cctgtccagt ctcccactac atgagtaccc acctgccttc     1560

ccactgggag ccgacatcca aggtttagat ttattttcat ttcttcagac agagagtcag     1620

cactatggcc cctctgtcat cacctcacta gatgaacagg atgcccttgg ccacttcttc     1680

cagtaccgag ggaccccttc tcactttctg ggcccactgg cccccacgct ggggagctcc     1740

cactgcagcg ccactccggc gccccctcct ggccgtgtca gcagcattgt ggcccctggg     1800

ggggccttga gggaggggca tggaggaccc ctgccctcag gtccctcttt gactggctgt     1860

cggtcagaca tcatttccct ggactga                                         1887


<210>  16
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Glu Leu Gly Glu Leu Lys His Met Val Met Ser Phe Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Phe Ala Gly Arg Asn Lys Ser Gly 
            20                  25                  30          


Arg Lys His Glu Leu Leu Ala Lys Ala Leu His Leu Leu Lys Ser Ser 
        35                  40                  45              


Cys Ala Pro Ser Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Phe Pro Arg Lys Thr Leu Gly Pro Ser Asp Leu Ser Leu Leu Ser Leu 
65                  70                  75                  80  


Pro Pro Gly Thr Ser Pro Val Gly Ser Pro Gly Pro Leu Ala Pro Ile 
                85                  90                  95      


Pro Pro Thr Leu Leu Ala Pro Gly Thr Leu Leu Gly Pro Lys Arg Glu 
            100                 105                 110         


Val Asp Met His Pro Pro Leu Pro Gln Pro Val His Pro Asp Val Thr 
        115                 120                 125             


Met Lys Pro Leu Pro Phe Tyr Glu Val Tyr Gly Glu Leu Ile Arg Pro 
    130                 135                 140                 


Thr Thr Leu Ala Ser Thr Ser Ser Gln Arg Phe Glu Glu Ala His Phe 
145                 150                 155                 160 


Thr Phe Ala Leu Thr Pro Gln Gln Val Gln Gln Ile Leu Thr Ser Arg 
                165                 170                 175     


Glu Val Leu Pro Gly Ala Lys Cys Asp Tyr Thr Ile Gln Val Gln Leu 
            180                 185                 190         


Arg Phe Cys Leu Cys Glu Thr Ser Cys Pro Gln Glu Asp Tyr Phe Pro 
        195                 200                 205             


Pro Asn Leu Phe Val Lys Val Asn Gly Lys Leu Cys Pro Leu Pro Gly 
    210                 215                 220                 


Tyr Leu Pro Pro Thr Lys Asn Gly Ala Glu Pro Lys Arg Pro Ser Arg 
225                 230                 235                 240 


Pro Ile Asn Ile Thr Pro Leu Ala Arg Leu Ser Ala Thr Val Pro Asn 
                245                 250                 255     


Thr Ile Val Val Asn Trp Ser Ser Glu Phe Gly Arg Asn Tyr Ser Leu 
            260                 265                 270         


Ser Val Tyr Leu Val Arg Gln Leu Thr Ala Gly Thr Leu Leu Gln Lys 
        275                 280                 285             


Leu Arg Ala Lys Gly Ile Arg Asn Pro Asp His Ser Arg Ala Leu Ile 
    290                 295                 300                 


Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Val Ala Thr Thr Ser 
305                 310                 315                 320 


Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met Arg Leu Thr Val 
                325                 330                 335     


Pro Cys Arg Ala Leu Thr Cys Ala His Leu Gln Ser Phe Asp Ala Ala 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Thr Cys Pro Val 
        355                 360                 365             


Cys Asp Lys Lys Ala Pro Tyr Glu Ser Leu Ile Ile Asp Gly Leu Phe 
    370                 375                 380                 


Met Glu Ile Leu Ser Ser Cys Ser Asp Cys Asp Glu Ile Gln Phe Met 
385                 390                 395                 400 


Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys Lys Glu Ala Ser Glu 
                405                 410                 415     


Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly Leu Gln Tyr Ser Pro 
            420                 425                 430         


Val Gln Gly Gly Asp Pro Ser Glu Asn Lys Lys Lys Val Glu Val Ile 
        435                 440                 445             


Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Asp Leu Pro Pro Thr 
    450                 455                 460                 


Lys Lys His Cys Ser Val Thr Ser Ala Ala Ile Pro Ala Leu Pro Gly 
465                 470                 475                 480 


Ser Lys Gly Val Leu Thr Ser Gly His Gln Pro Ser Ser Val Leu Arg 
                485                 490                 495     


Ser Pro Ala Met Gly Thr Leu Gly Gly Asp Phe Leu Ser Ser Leu Pro 
            500                 505                 510         


Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly Ala Asp Ile Gln Gly 
        515                 520                 525             


Leu Asp Leu Phe Ser Phe Leu Gln Thr Glu Ser Gln His Tyr Gly Pro 
    530                 535                 540                 


Ser Val Ile Thr Ser Leu Asp Glu Gln Asp Ala Leu Gly His Phe Phe 
545                 550                 555                 560 


Gln Tyr Arg Gly Thr Pro Ser His Phe Leu Gly Pro Leu Ala Pro Thr 
                565                 570                 575     


Leu Gly Ser Ser His Cys Ser Ala Thr Pro Ala Pro Pro Pro Gly Arg 
            580                 585                 590         


Val Ser Ser Ile Val Ala Pro Gly Gly Ala Leu Arg Glu Gly His Gly 
        595                 600                 605             


Gly Pro Leu Pro Ser Gly Pro Ser Leu Thr Gly Cys Arg Ser Asp Ile 
    610                 615                 620                 


Ile Ser Leu Asp 
625             


<210>  17
<211>  1533
<212>  DNA
<213>  Homo sapiens

<400>  17
atggcggcgg agctggtgga ggccaaaaac atggtgatga gttttcgagt ctccgacctt       60

cagatgctcc tgggtttcgt gggccggagt aagagtggac tgaagcacga gctcgtcacc      120

agggccctcc agctggtgca gtttgactgt agccctgagc tgttcaagaa gatcaaggag      180

ctgtacgaga cccgctacgc caagaagaac tcggagcctg ccccacagcc gcaccggccc      240

ctggaccccc tgaccatgca ctccacctac gaccgggccg gcgctgtgcc caggactccg      300

ctggcaggcc ccaatattga ctaccccgtg ctctacggaa agtacttaaa cggactggga      360

cggttgcccg ccaagaccct caagccagaa gtccgcctgg tgaagctgcc gttctttaat      420

atgctggatg agctgctgaa gcccaccgaa ttagtcccac agaacaacga gaagcttcag      480

gagagcccgt gcatcttcgc attgacgcca agacaggtgg agttgatccg gaactccagg      540

gaactgcagc ccggagttaa agccgtgcag gtcgtcctga gaatctgtta ctcagacacc      600

agctgccctc aggaggacca gtacccgccc aacatcgctg tgaaggtcaa ccacagctac      660

tgctccgtcc cgggctacta cccctccaat aagcccgggg tggagcccaa gaggccgtgc      720

cgccccatca acctcactca cctcatgtac ctgtcctcgg ccaccaaccg catcactgtc      780

acctggggga actacggcaa gagctactcg gtggccctgt acctggtgcg gcagctgacc      840

tcatcggagc tgctgcagag gctgaagacc attggggtaa agcacccgga gctgtgcaag      900

gcactggtca aggagaagct gcgccttgat cctgacagcg agatcgccac caccggtgtg      960

cgggtgtccc tcatctgtcc gctggtgaag atgcggctct ccgtgccctg ccgggcagag     1020

acctgcgccc acctgcagtg cttcgacgcc gtcttctacc tgcagatgaa cgagaagaag     1080

cccacctgga tgtgccccgt gtgcgacaag ccagccccct acgaccagct catcatcgac     1140

gggctcctct cgaagatcct gagcgagtgt gaggacgccg acgagatcga gtacctggtg     1200

gacggctcgt ggtgcccgat ccgcgccgaa aaggagcgca gctgcagccc gcagggcgcc     1260

atcctcgtgc tgggcccctc ggacgccaat gggctcctgc ccgcccccag cgtcaacggg     1320

agcggtgccc tgggcagcac gggtggcggc ggcccggtgg gcagcatgga gaatgggaag     1380

ccgggcgccg atgtggtgga cctcacgctg gacagctcat cgtcctcgga ggatgaggag     1440

gaggaggaag aggaggagga agacgaggac gaagaggggc cccggcccaa gcgccgctgc     1500

cccttccaga agggcctggt gccggcctgc tga                                  1533


<210>  18
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ala Glu Leu Val Glu Ala Lys Asn Met Val Met Ser Phe Arg 
1               5                   10                  15      


Val Ser Asp Leu Gln Met Leu Leu Gly Phe Val Gly Arg Ser Lys Ser 
            20                  25                  30          


Gly Leu Lys His Glu Leu Val Thr Arg Ala Leu Gln Leu Val Gln Phe 
        35                  40                  45              


Asp Cys Ser Pro Glu Leu Phe Lys Lys Ile Lys Glu Leu Tyr Glu Thr 
    50                  55                  60                  


Arg Tyr Ala Lys Lys Asn Ser Glu Pro Ala Pro Gln Pro His Arg Pro 
65                  70                  75                  80  


Leu Asp Pro Leu Thr Met His Ser Thr Tyr Asp Arg Ala Gly Ala Val 
                85                  90                  95      


Pro Arg Thr Pro Leu Ala Gly Pro Asn Ile Asp Tyr Pro Val Leu Tyr 
            100                 105                 110         


Gly Lys Tyr Leu Asn Gly Leu Gly Arg Leu Pro Ala Lys Thr Leu Lys 
        115                 120                 125             


Pro Glu Val Arg Leu Val Lys Leu Pro Phe Phe Asn Met Leu Asp Glu 
    130                 135                 140                 


Leu Leu Lys Pro Thr Glu Leu Val Pro Gln Asn Asn Glu Lys Leu Gln 
145                 150                 155                 160 


Glu Ser Pro Cys Ile Phe Ala Leu Thr Pro Arg Gln Val Glu Leu Ile 
                165                 170                 175     


Arg Asn Ser Arg Glu Leu Gln Pro Gly Val Lys Ala Val Gln Val Val 
            180                 185                 190         


Leu Arg Ile Cys Tyr Ser Asp Thr Ser Cys Pro Gln Glu Asp Gln Tyr 
        195                 200                 205             


Pro Pro Asn Ile Ala Val Lys Val Asn His Ser Tyr Cys Ser Val Pro 
    210                 215                 220                 


Gly Tyr Tyr Pro Ser Asn Lys Pro Gly Val Glu Pro Lys Arg Pro Cys 
225                 230                 235                 240 


Arg Pro Ile Asn Leu Thr His Leu Met Tyr Leu Ser Ser Ala Thr Asn 
                245                 250                 255     


Arg Ile Thr Val Thr Trp Gly Asn Tyr Gly Lys Ser Tyr Ser Val Ala 
            260                 265                 270         


Leu Tyr Leu Val Arg Gln Leu Thr Ser Ser Glu Leu Leu Gln Arg Leu 
        275                 280                 285             


Lys Thr Ile Gly Val Lys His Pro Glu Leu Cys Lys Ala Leu Val Lys 
    290                 295                 300                 


Glu Lys Leu Arg Leu Asp Pro Asp Ser Glu Ile Ala Thr Thr Gly Val 
305                 310                 315                 320 


Arg Val Ser Leu Ile Cys Pro Leu Val Lys Met Arg Leu Ser Val Pro 
                325                 330                 335     


Cys Arg Ala Glu Thr Cys Ala His Leu Gln Cys Phe Asp Ala Val Phe 
            340                 345                 350         


Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Met Cys Pro Val Cys 
        355                 360                 365             


Asp Lys Pro Ala Pro Tyr Asp Gln Leu Ile Ile Asp Gly Leu Leu Ser 
    370                 375                 380                 


Lys Ile Leu Ser Glu Cys Glu Asp Ala Asp Glu Ile Glu Tyr Leu Val 
385                 390                 395                 400 


Asp Gly Ser Trp Cys Pro Ile Arg Ala Glu Lys Glu Arg Ser Cys Ser 
                405                 410                 415     


Pro Gln Gly Ala Ile Leu Val Leu Gly Pro Ser Asp Ala Asn Gly Leu 
            420                 425                 430         


Leu Pro Ala Pro Ser Val Asn Gly Ser Gly Ala Leu Gly Ser Thr Gly 
        435                 440                 445             


Gly Gly Gly Pro Val Gly Ser Met Glu Asn Gly Lys Pro Gly Ala Asp 
    450                 455                 460                 


Val Val Asp Leu Thr Leu Asp Ser Ser Ser Ser Ser Glu Asp Glu Glu 
465                 470                 475                 480 


Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu Gly Pro Arg Pro 
                485                 490                 495     


Lys Arg Arg Cys Pro Phe Gln Lys Gly Leu Val Pro Ala Cys 
            500                 505                 510 


<210>  19
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  19
atggtagcac acaaccaggt ggcagccgac aatgcagtct ccacagcagc agagccccga       60

cggcggccag aaccttcctc ctcttcctcc tcctcgcccg cggcccccgc gcgcccgcgg      120

ccgtgccccg cggtcccggc cccggccccc ggcgacacgc acttccgcac attccgttcg      180

cacgccgatt accggcgcat cacgcgcgcc agcgcgctcc tggacgcctg cggattctac      240

tgggggcccc tgagcgtgca cggggcgcac gagcggctgc gcgccgagcc cgtgggcacc      300

ttcctggtgc gcgacagccg ccagcggaac tgctttttcg cccttagcgt gaagatggcc      360

tcgggaccca cgagcatccg cgtgcacttt caggccggcc gctttcacct ggatggcagc      420

cgcgagagct tcgactgcct cttcgagctg ctggagcact acgtggcggc gccgcgccgc      480

atgctggggg ccccgctgcg ccagcgccgc gtgcggccgc tgcaggagct gtgccgccag      540

cgcatcgtgg ccaccgtggg ccgcgagaac ctggctcgca tccccctcaa ccccgtcctc      600

cgcgactacc tgagctcctt ccccttccag atttga                                636


<210>  20
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Val Ala His Asn Gln Val Ala Ala Asp Asn Ala Val Ser Thr Ala 
1               5                   10                  15      


Ala Glu Pro Arg Arg Arg Pro Glu Pro Ser Ser Ser Ser Ser Ser Ser 
            20                  25                  30          


Pro Ala Ala Pro Ala Arg Pro Arg Pro Cys Pro Ala Val Pro Ala Pro 
        35                  40                  45              


Ala Pro Gly Asp Thr His Phe Arg Thr Phe Arg Ser His Ala Asp Tyr 
    50                  55                  60                  


Arg Arg Ile Thr Arg Ala Ser Ala Leu Leu Asp Ala Cys Gly Phe Tyr 
65                  70                  75                  80  


Trp Gly Pro Leu Ser Val His Gly Ala His Glu Arg Leu Arg Ala Glu 
                85                  90                  95      


Pro Val Gly Thr Phe Leu Val Arg Asp Ser Arg Gln Arg Asn Cys Phe 
            100                 105                 110         


Phe Ala Leu Ser Val Lys Met Ala Ser Gly Pro Thr Ser Ile Arg Val 
        115                 120                 125             


His Phe Gln Ala Gly Arg Phe His Leu Asp Gly Ser Arg Glu Ser Phe 
    130                 135                 140                 


Asp Cys Leu Phe Glu Leu Leu Glu His Tyr Val Ala Ala Pro Arg Arg 
145                 150                 155                 160 


Met Leu Gly Ala Pro Leu Arg Gln Arg Arg Val Arg Pro Leu Gln Glu 
                165                 170                 175     


Leu Cys Arg Gln Arg Ile Val Ala Thr Val Gly Arg Glu Asn Leu Ala 
            180                 185                 190         


Arg Ile Pro Leu Asn Pro Val Leu Arg Asp Tyr Leu Ser Ser Phe Pro 
        195                 200                 205             


Phe Gln Ile 
    210     


<210>  21
<211>  678
<212>  DNA
<213>  Homo sapiens

<400>  21
atggtcaccc acagcaagtt tcccgccgcc gggatgagcc gccccctgga caccagcctg       60

cgcctcaaga ccttcagctc caagagcgag taccagctgg tggtgaacgc agtgcgcaag      120

ctgcaggaga gcggcttcta ctggagcgca gtgaccggcg gcgaggcgaa cctgctgctc      180

agtgccgagc ccgccggcac ctttctgatc cgcgacagct cggaccagcg ccacttcttc      240

acgctcagcg tcaagaccca gtctgggacc aagaacctgc gcatccagtg tgaggggggc      300

agcttctctc tgcagagcga tccccggagc acgcagcccg tgccccgctt cgactgcgtg      360

ctcaagctgg tgcaccacta catgccgccc cctggagccc cctccttccc ctcgccacct      420

actgaaccct cctccgaggt gcccgagcag ccgtctgccc agccactccc tgggagtccc      480

cccagaagag cctattacat ctactccggg ggcgagaaga tccccctggt gttgagccgg      540

cccctctcct ccaacgtggc cactcttcag catctctgtc ggaagaccgt caacggccac      600

ctggactcct atgagaaagt cacccagctg ccggggccca ttcgggagtt cctggaccag      660

tacgatgccc cgctttaa                                                    678


<210>  22
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Val Thr His Ser Lys Phe Pro Ala Ala Gly Met Ser Arg Pro Leu 
1               5                   10                  15      


Asp Thr Ser Leu Arg Leu Lys Thr Phe Ser Ser Lys Ser Glu Tyr Gln 
            20                  25                  30          


Leu Val Val Asn Ala Val Arg Lys Leu Gln Glu Ser Gly Phe Tyr Trp 
        35                  40                  45              


Ser Ala Val Thr Gly Gly Glu Ala Asn Leu Leu Leu Ser Ala Glu Pro 
    50                  55                  60                  


Ala Gly Thr Phe Leu Ile Arg Asp Ser Ser Asp Gln Arg His Phe Phe 
65                  70                  75                  80  


Thr Leu Ser Val Lys Thr Gln Ser Gly Thr Lys Asn Leu Arg Ile Gln 
                85                  90                  95      


Cys Glu Gly Gly Ser Phe Ser Leu Gln Ser Asp Pro Arg Ser Thr Gln 
            100                 105                 110         


Pro Val Pro Arg Phe Asp Cys Val Leu Lys Leu Val His His Tyr Met 
        115                 120                 125             


Pro Pro Pro Gly Ala Pro Ser Phe Pro Ser Pro Pro Thr Glu Pro Ser 
    130                 135                 140                 


Ser Glu Val Pro Glu Gln Pro Ser Ala Gln Pro Leu Pro Gly Ser Pro 
145                 150                 155                 160 


Pro Arg Arg Ala Tyr Tyr Ile Tyr Ser Gly Gly Glu Lys Ile Pro Leu 
                165                 170                 175     


Val Leu Ser Arg Pro Leu Ser Ser Asn Val Ala Thr Leu Gln His Leu 
            180                 185                 190         


Cys Arg Lys Thr Val Asn Gly His Leu Asp Ser Tyr Glu Lys Val Thr 
        195                 200                 205             


Gln Leu Pro Gly Pro Ile Arg Glu Phe Leu Asp Gln Tyr Asp Ala Pro 
    210                 215                 220                 


Leu 
225 


<210>  23
<211>  1788
<212>  DNA
<213>  Homo sapiens

<400>  23
atggtgaggt ggtttcaccg agacctcagt gggctggatg cagagaccct gctcaagggc       60

cgaggtgtcc acggtagctt cctggctcgg cccagtcgca agaaccaggg tgacttctcg      120

ctctccgtca gggtggggga tcaggtgacc catattcgga tccagaactc aggggatttc      180

tatgacctgt atggagggga gaagtttgcg actctgacag agctggtgga gtactacact      240

cagcagcagg gtgtcctgca ggaccgcgac ggcaccatca tccacctcaa gtacccgctg      300

aactgctccg atcccactag tgagaggtgg taccatggcc acatgtctgg cgggcaggca      360

gagacgctgc tgcaggccaa gggcgagccc tggacgtttc ttgtgcgtga gagcctcagc      420

cagcctggag acttcgtgct ttctgtgctc agtgaccagc ccaaggctgg cccaggctcc      480

ccgctcaggg tcacccacat caaggtcatg tgcgagggtg gacgctacac agtgggtggt      540

ttggagacct tcgacagcct cacggacctg gtggagcatt tcaagaagac ggggattgag      600

gaggcctcag gcgcctttgt ctacctgcgg cagccgtact atgccacgag ggtgaatgcg      660

gctgacattg agaaccgagt gttggaactg aacaagaagc aggagtccga ggatacagcc      720

aaggctggct tctgggagga gtttgagagt ttgcagaagc aggaggtgaa gaacttgcac      780

cagcgtctgg aagggcagcg gccagagaac aagggcaaga accgctacaa gaacattctc      840

ccctttgacc acagccgagt gatcctgcag ggacgggaca gtaacatccc cgggtccgac      900

tacatcaatg ccaactacat caagaaccag ctgctaggcc ctgatgagaa cgctaagacc      960

tacatcgcca gccagggctg tctggaggcc acggtcaatg acttctggca gatggcgtgg     1020

caggagaaca gccgtgtcat cgtcatgacc acccgagagg tggagaaagg ccggaacaaa     1080

tgcgtcccat actggcccga ggtgggcatg cagcgtgctt atgggcccta ctctgtgacc     1140

aactgcgggg agcatgacac aaccgaatac aaactccgta ccttacaggt ctccccgctg     1200

gacaatggag acctgattcg ggagatctgg cattaccagt acctgagctg gcccgaccat     1260

ggggtcccca gtgagcctgg gggtgtcctc agcttcctgg accagatcaa ccagcggcag     1320

gaaagtctgc ctcacgcagg gcccatcatc gtgcactgca gcgccggcat cggccgcaca     1380

ggcaccatca ttgtcatcga catgctcatg gagaacatct ccaccaaggg cctggactgt     1440

gacattgaca tccagaagac catccagatg gtgcgggcgc agcgctcggg catggtgcag     1500

acggaggcgc agtacaagtt catctacgtg gccatcgccc agttcattga aaccactaag     1560

aagaagctgg aggtcctgca gtcgcagaag ggccaggagt cggagtacgg gaacatcacc     1620

tatcccccag ccatgaagaa tgcccatgcc aaggcctccc gcacctcgtc caaacacaag     1680

gaggatgtgt atgagaacct gcacactaag aacaagaggg aggagaaagt gaagaagcag     1740

cggtcagcag acaaggagaa gagcaagggt tccctcaaga ggaagtga                  1788


<210>  24
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Val Arg Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr 
1               5                   10                  15      


Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser 
            20                  25                  30          


Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln 
        35                  40                  45              


Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr 
    50                  55                  60                  


Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr 
65                  70                  75                  80  


Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu 
                85                  90                  95      


Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp Tyr His 
            100                 105                 110         


Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala Lys Gly 
        115                 120                 125             


Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro Gly Asp 
    130                 135                 140                 


Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly Arg Tyr 
                165                 170                 175     


Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu Val Glu 
            180                 185                 190         


His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe Val Tyr 
        195                 200                 205             


Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val Asn Ala Ala Asp Ile Glu 
    210                 215                 220                 


Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Glu Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val 
                245                 250                 255     


Lys Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly 
            260                 265                 270         


Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile 
        275                 280                 285             


Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala 
    290                 295                 300                 


Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr 
305                 310                 315                 320 


Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp 
                325                 330                 335     


Gln Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg 
            340                 345                 350         


Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val 
        355                 360                 365             


Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu 
    370                 375                 380                 


His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu 
385                 390                 395                 400 


Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser 
                405                 410                 415     


Trp Pro Asp His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe 
            420                 425                 430         


Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro 
        435                 440                 445             


Ile Ile Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile 
    450                 455                 460                 


Val Ile Asp Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys 
465                 470                 475                 480 


Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser 
                485                 490                 495     


Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile 
            500                 505                 510         


Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu Gln Ser 
        515                 520                 525             


Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro Pro Ala 
    530                 535                 540                 


Met Lys Asn Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys His Lys 
545                 550                 555                 560 


Glu Asp Val Tyr Glu Asn Leu His Thr Lys Asn Lys Arg Glu Glu Lys 
                565                 570                 575     


Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Lys Ser Lys Gly Ser Leu 
            580                 585                 590         


Lys Arg Lys 
        595 


<210>  25
<211>  1794
<212>  DNA
<213>  Homo sapiens

<400>  25
atgctgtccc gtgggtggtt tcaccgagac ctcagtgggc tggatgcaga gaccctgctc       60

aagggccgag gtgtccacgg tagcttcctg gctcggccca gtcgcaagaa ccagggtgac      120

ttctcgctct ccgtcagggt gggggatcag gtgacccata ttcggatcca gaactcaggg      180

gatttctatg acctgtatgg aggggagaag tttgcgactc tgacagagct ggtggagtac      240

tacactcagc agcagggtgt cctgcaggac cgcgacggca ccatcatcca cctcaagtac      300

ccgctgaact gctccgatcc cactagtgag aggtggtacc atggccacat gtctggcggg      360

caggcagaga cgctgctgca ggccaagggc gagccctgga cgtttcttgt gcgtgagagc      420

ctcagccagc ctggagactt cgtgctttct gtgctcagtg accagcccaa ggctggccca      480

ggctccccgc tcagggtcac ccacatcaag gtcatgtgcg agggtggacg ctacacagtg      540

ggtggtttgg agaccttcga cagcctcacg gacctggtgg agcatttcaa gaagacgggg      600

attgaggagg cctcaggcgc ctttgtctac ctgcggcagc cgtactatgc cacgagggtg      660

aatgcggctg acattgagaa ccgagtgttg gaactgaaca agaagcagga gtccgaggat      720

acagccaagg ctggcttctg ggaggagttt gagagtttgc agaagcagga ggtgaagaac      780

ttgcaccagc gtctggaagg gcagcggcca gagaacaagg gcaagaaccg ctacaagaac      840

attctcccct ttgaccacag ccgagtgatc ctgcagggac gggacagtaa catccccggg      900

tccgactaca tcaatgccaa ctacatcaag aaccagctgc taggccctga tgagaacgct      960

aagacctaca tcgccagcca gggctgtctg gaggccacgg tcaatgactt ctggcagatg     1020

gcgtggcagg agaacagccg tgtcatcgtc atgaccaccc gagaggtgga gaaaggccgg     1080

aacaaatgcg tcccatactg gcccgaggtg ggcatgcagc gtgcttatgg gccctactct     1140

gtgaccaact gcggggagca tgacacaacc gaatacaaac tccgtacctt acaggtctcc     1200

ccgctggaca atggagacct gattcgggag atctggcatt accagtacct gagctggccc     1260

gaccatgggg tccccagtga gcctgggggt gtcctcagct tcctggacca gatcaaccag     1320

cggcaggaaa gtctgcctca cgcagggccc atcatcgtgc actgcagcgc cggcatcggc     1380

cgcacaggca ccatcattgt catcgacatg ctcatggaga acatctccac caagggcctg     1440

gactgtgaca ttgacatcca gaagaccatc cagatggtgc gggcgcagcg ctcgggcatg     1500

gtgcagacgg aggcgcagta caagttcatc tacgtggcca tcgcccagtt cattgaaacc     1560

actaagaaga agctggaggt cctgcagtcg cagaagggcc aggagtcgga gtacgggaac     1620

atcacctatc ccccagccat gaagaatgcc catgccaagg cctcccgcac ctcgtccaaa     1680

cacaaggagg atgtgtatga gaacctgcac actaagaaca agagggagga gaaagtgaag     1740

aagcagcggt cagcagacaa ggagaagagc aagggttccc tcaagaggaa gtga           1794


<210>  26
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Leu Ser Arg Gly Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala 
1               5                   10                  15      


Glu Thr Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg 
            20                  25                  30          


Pro Ser Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly 
        35                  40                  45              


Asp Gln Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp 
    50                  55                  60                  


Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr 
65                  70                  75                  80  


Tyr Thr Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile 
                85                  90                  95      


His Leu Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp 
            100                 105                 110         


Tyr His Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala 
        115                 120                 125             


Lys Gly Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro 
    130                 135                 140                 


Gly Asp Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro 
145                 150                 155                 160 


Gly Ser Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly 
                165                 170                 175     


Arg Tyr Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu 
            180                 185                 190         


Val Glu His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe 
        195                 200                 205             


Val Tyr Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val Asn Ala Ala Asp 
    210                 215                 220                 


Ile Glu Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Glu Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln 
                245                 250                 255     


Glu Val Lys Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn 
            260                 265                 270         


Lys Gly Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg 
        275                 280                 285             


Val Ile Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile 
    290                 295                 300                 


Asn Ala Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala 
305                 310                 315                 320 


Lys Thr Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp 
                325                 330                 335     


Phe Trp Gln Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr 
            340                 345                 350         


Thr Arg Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro 
        355                 360                 365             


Glu Val Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys 
    370                 375                 380                 


Gly Glu His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser 
385                 390                 395                 400 


Pro Leu Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr 
                405                 410                 415     


Leu Ser Trp Pro Asp His Gly Val Pro Ser Glu Pro Gly Gly Val Leu 
            420                 425                 430         


Ser Phe Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala 
        435                 440                 445             


Gly Pro Ile Ile Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr 
    450                 455                 460                 


Ile Ile Val Ile Asp Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu 
465                 470                 475                 480 


Asp Cys Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln 
                485                 490                 495     


Arg Ser Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val 
            500                 505                 510         


Ala Ile Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu 
        515                 520                 525             


Gln Ser Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro 
    530                 535                 540                 


Pro Ala Met Lys Asn Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys 
545                 550                 555                 560 


His Lys Glu Asp Val Tyr Glu Asn Leu His Thr Lys Asn Lys Arg Glu 
                565                 570                 575     


Glu Lys Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Lys Ser Lys Gly 
            580                 585                 590         


Ser Leu Lys Arg Lys 
        595         


<210>  27
<211>  1875
<212>  DNA
<213>  Homo sapiens

<400>  27
atggtgaggt ggtttcaccg agacctcagt gggctggatg cagagaccct gctcaagggc       60

cgaggtgtcc acggtagctt cctggctcgg cccagtcgca agaaccaggg tgacttctcg      120

ctctccgtca gggtggggga tcaggtgacc catattcgga tccagaactc aggggatttc      180

tatgacctgt atggagggga gaagtttgcg actctgacag agctggtgga gtactacact      240

cagcagcagg gtgtcctgca ggaccgcgac ggcaccatca tccacctcaa gtacccgctg      300

aactgctccg atcccactag tgagaggtgg taccatggcc acatgtctgg cgggcaggca      360

gagacgctgc tgcaggccaa gggcgagccc tggacgtttc ttgtgcgtga gagcctcagc      420

cagcctggag acttcgtgct ttctgtgctc agtgaccagc ccaaggctgg cccaggctcc      480

ccgctcaggg tcacccacat caaggtcatg tgcgagggtg gacgctacac agtgggtggt      540

ttggagacct tcgacagcct cacggacctg gtggagcatt tcaagaagac ggggattgag      600

gaggcctcag gcgcctttgt ctacctgcgg cagccgtact atgccacgag ggtgaatgcg      660

gctgacattg agaaccgagt gttggaactg aacaagaagc aggagtccga ggatacagcc      720

aaggctggct tctgggagga gtttgagagt ttgcagaagc aggaggtgaa gaacttgcac      780

cagcgtctgg aagggcagcg gccagagaac aagggcaaga accgctacaa gaacattctc      840

ccctttgacc acagccgagt gatcctgcag ggacgggaca gtaacatccc cgggtccgac      900

tacatcaatg ccaactacat caagaaccag ctgctaggcc ctgatgagaa cgctaagacc      960

tacatcgcca gccagggctg tctggaggcc acggtcaatg acttctggca gatggcgtgg     1020

caggagaaca gccgtgtcat cgtcatgacc acccgagagg tggagaaagg ccggaacaaa     1080

tgcgtcccat actggcccga ggtgggcatg cagcgtgctt atgggcccta ctctgtgacc     1140

aactgcgggg agcatgacac aaccgaatac aaactccgta ccttacaggt ctccccgctg     1200

gacaatggag acctgattcg ggagatctgg cattaccagt acctgagctg gcccgaccat     1260

ggggtcccca gtgagcctgg gggtgtcctc agcttcctgg accagatcaa ccagcggcag     1320

gaaagtctgc ctcacgcagg gcccatcatc gtgcactgca gcgccggcat cggccgcaca     1380

ggcaccatca ttgtcatcga catgctcatg gagaacatct ccaccaaggg cctggactgt     1440

gacattgaca tccagaagac catccagatg gtgcgggcgc agcgctcggg catggtgcag     1500

acggaggcgc agtacaagtt catctacgtg gccatcgccc agttcattga aaccactaag     1560

aagaagctgg aggtcctgca gtcgcagaag ggccaggagt cggagtacgg gaacatcacc     1620

tatcccccag ccatgaagaa tgcccatgcc aaggcctccc gcacctcgtc caagagcttg     1680

gagtctagtg cagggaccgt ggctgcgtca cctgtgagac ggggtggcca gaggggactg     1740

ccagtgccgg gtccccctgt gctgtctcct gacctgcacc aactgcctgt acttgccccc     1800

ctgcacccgg ctgcagacac aaggaggatg tgtatgagaa cctgcacact aagaacaaga     1860

gggaggagaa agtga                                                      1875


<210>  28
<211>  624
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Val Arg Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr 
1               5                   10                  15      


Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser 
            20                  25                  30          


Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln 
        35                  40                  45              


Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr 
    50                  55                  60                  


Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr 
65                  70                  75                  80  


Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu 
                85                  90                  95      


Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp Tyr His 
            100                 105                 110         


Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala Lys Gly 
        115                 120                 125             


Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro Gly Asp 
    130                 135                 140                 


Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly Arg Tyr 
                165                 170                 175     


Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu Val Glu 
            180                 185                 190         


His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe Val Tyr 
        195                 200                 205             


Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val Asn Ala Ala Asp Ile Glu 
    210                 215                 220                 


Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Glu Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val 
                245                 250                 255     


Lys Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly 
            260                 265                 270         


Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile 
        275                 280                 285             


Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala 
    290                 295                 300                 


Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr 
305                 310                 315                 320 


Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp 
                325                 330                 335     


Gln Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg 
            340                 345                 350         


Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val 
        355                 360                 365             


Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu 
    370                 375                 380                 


His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu 
385                 390                 395                 400 


Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser 
                405                 410                 415     


Trp Pro Asp His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe 
            420                 425                 430         


Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro 
        435                 440                 445             


Ile Ile Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile 
    450                 455                 460                 


Val Ile Asp Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys 
465                 470                 475                 480 


Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser 
                485                 490                 495     


Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile 
            500                 505                 510         


Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu Gln Ser 
        515                 520                 525             


Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro Pro Ala 
    530                 535                 540                 


Met Lys Asn Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys Ser Leu 
545                 550                 555                 560 


Glu Ser Ser Ala Gly Thr Val Ala Ala Ser Pro Val Arg Arg Gly Gly 
                565                 570                 575     


Gln Arg Gly Leu Pro Val Pro Gly Pro Pro Val Leu Ser Pro Asp Leu 
            580                 585                 590         


His Gln Leu Pro Val Leu Ala Pro Leu His Pro Ala Ala Asp Thr Arg 
        595                 600                 605             


Arg Met Cys Met Arg Thr Cys Thr Leu Arg Thr Arg Gly Arg Arg Lys 
    610                 615                 620                 


<210>  29
<211>  1782
<212>  DNA
<213>  Homo sapiens

<400>  29
atgacatcgc ggagatggtt tcacccaaat atcactggtg tggaggcaga aaacctactg       60

ttgacaagag gagttgatgg cagttttttg gcaaggccta gtaaaagtaa ccctggagac      120

ttcacacttt ccgttagaag aaatggagct gtcacccaca tcaagattca gaacactggt      180

gattactatg acctgtatgg aggggagaaa tttgccactt tggctgagtt ggtccagtat      240

tacatggaac atcacgggca attaaaagag aagaatggag atgtcattga gcttaaatat      300

cctctgaact gtgcagatcc tacctctgaa aggtggtttc atggacatct ctctgggaaa      360

gaagcagaga aattattaac tgaaaaagga aaacatggta gttttcttgt acgagagagc      420

cagagccacc ctggagattt tgttctttct gtgcgcactg gtgatgacaa aggggagagc      480

aatgacggca agtctaaagt gacccatgtt atgattcgct gtcaggaact gaaatacgac      540

gttggtggag gagaacggtt tgattctttg acagatcttg tggaacatta taagaagaat      600

cctatggtgg aaacattggg tacagtacta caactcaagc agccccttaa cacgactcgt      660

ataaatgctg ctgaaataga aagcagagtt cgagaactaa gcaaattagc tgagaccaca      720

gataaagtca aacaaggctt ttgggaagaa tttgagacac tacaacaaca ggagtgcaaa      780

cttctctaca gccgaaaaga gggtcaaagg caagaaaaca aaaacaaaaa tagatataaa      840

aacatcctgc cctttgatca taccagggtt gtcctacacg atggtgatcc caatgagcct      900

gtttcagatt acatcaatgc aaatatcatc atgcctgaat ttgaaaccaa gtgcaacaat      960

tcaaagccca aaaagagtta cattgccaca caaggctgcc tgcaaaacac ggtgaatgac     1020

ttttggcgga tggtgttcca agaaaactcc cgagtgattg tcatgacaac gaaagaagtg     1080

gagagaggaa agagtaaatg tgtcaaatac tggcctgatg agtatgctct aaaagaatat     1140

ggcgtcatgc gtgttaggaa cgtcaaagaa agcgccgctc atgactatac gctaagagaa     1200

cttaaacttt caaaggttgg acaagggaat acggagagaa cggtctggca ataccacttt     1260

cggacctggc cggaccacgg cgtgcccagc gaccctgggg gcgtgctgga cttcctggag     1320

gaggtgcacc ataagcagga gagcatcatg gatgcagggc cggtcgtggt gcactgcagt     1380

gctggaattg gccggacagg gacgttcatt gtgattgata ttcttattga catcatcaga     1440

gagaaaggtg ttgactgcga tattgacgtt cccaaaacca tccagatggt gcggtctcag     1500

aggtcaggga tggtccagac agaagcacag taccgattta tctatatggc ggtccagcat     1560

tatattgaaa cactacagcg caggattgaa gaagagcaga aaagcaagag gaaagggcac     1620

gaatatacaa atattaagta ttctctagcg gaccagacga gtggagatca gagccctctc     1680

ccgccttgta ctccaacgcc accctgtgca gaaatgagag aagacagtgc tagagtctat     1740

gaaaacgtgg gcctgatgca acagcagaaa agtttcagat ga                        1782


<210>  30
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Thr Ser Arg Arg Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala 
1               5                   10                  15      


Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg 
            20                  25                  30          


Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn 
        35                  40                  45              


Gly Ala Val Thr His Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp 
    50                  55                  60                  


Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr 
65                  70                  75                  80  


Tyr Met Glu His His Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile 
                85                  90                  95      


Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pro Thr Ser Glu Arg Trp 
            100                 105                 110         


Phe His Gly His Leu Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr Glu 
        115                 120                 125             


Lys Gly Lys His Gly Ser Phe Leu Val Arg Glu Ser Gln Ser His Pro 
    130                 135                 140                 


Gly Asp Phe Val Leu Ser Val Arg Thr Gly Asp Asp Lys Gly Glu Ser 
145                 150                 155                 160 


Asn Asp Gly Lys Ser Lys Val Thr His Val Met Ile Arg Cys Gln Glu 
                165                 170                 175     


Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr Asp 
            180                 185                 190         


Leu Val Glu His Tyr Lys Lys Asn Pro Met Val Glu Thr Leu Gly Thr 
        195                 200                 205             


Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Thr Arg Ile Asn Ala Ala 
    210                 215                 220                 


Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Lys Leu Ala Glu Thr Thr 
225                 230                 235                 240 


Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln 
                245                 250                 255     


Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu 
            260                 265                 270         


Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Thr 
        275                 280                 285             


Arg Val Val Leu His Asp Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr 
    290                 295                 300                 


Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Glu Thr Lys Cys Asn Asn 
305                 310                 315                 320 


Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn 
                325                 330                 335     


Thr Val Asn Asp Phe Trp Arg Met Val Phe Gln Glu Asn Ser Arg Val 
            340                 345                 350         


Ile Val Met Thr Thr Lys Glu Val Glu Arg Gly Lys Ser Lys Cys Val 
        355                 360                 365             


Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg 
    370                 375                 380                 


Val Arg Asn Val Lys Glu Ser Ala Ala His Asp Tyr Thr Leu Arg Glu 
385                 390                 395                 400 


Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Thr Glu Arg Thr Val Trp 
                405                 410                 415     


Gln Tyr His Phe Arg Thr Trp Pro Asp His Gly Val Pro Ser Asp Pro 
            420                 425                 430         


Gly Gly Val Leu Asp Phe Leu Glu Glu Val His His Lys Gln Glu Ser 
        435                 440                 445             


Ile Met Asp Ala Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly 
    450                 455                 460                 


Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Leu Ile Asp Ile Ile Arg 
465                 470                 475                 480 


Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pro Lys Thr Ile Gln Met 
                485                 490                 495     


Val Arg Ser Gln Arg Ser Gly Met Val Gln Thr Glu Ala Gln Tyr Arg 
            500                 505                 510         


Phe Ile Tyr Met Ala Val Gln His Tyr Ile Glu Thr Leu Gln Arg Arg 
        515                 520                 525             


Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gly His Glu Tyr Thr Asn 
    530                 535                 540                 


Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gly Asp Gln Ser Pro Leu 
545                 550                 555                 560 


Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Glu Met Arg Glu Asp Ser 
                565                 570                 575     


Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gln Gln Gln Lys Ser Phe 
            580                 585                 590         


Arg 
    


<210>  31
<211>  1383
<212>  DNA
<213>  Homo sapiens

<400>  31
atgacatcgc ggagatggtt tcacccaaat atcactggtg tggaggcaga aaacctactg       60

ttgacaagag gagttgatgg cagttttttg gcaaggccta gtaaaagtaa ccctggagac      120

ttcacacttt ccgttagaag aaatggagct gtcacccaca tcaagattca gaacactggt      180

gattactatg acctgtatgg aggggagaaa tttgccactt tggctgagtt ggtccagtat      240

tacatggaac atcacgggca attaaaagag aagaatggag atgtcattga gcttaaatat      300

cctctgaact gtgcagatcc tacctctgaa aggtggtttc atggacatct ctctgggaaa      360

gaagcagaga aattattaac tgaaaaagga aaacatggta gttttcttgt acgagagagc      420

cagagccacc ctggagattt tgttctttct gtgcgcactg gtgatgacaa aggggagagc      480

aatgacggca agtctaaagt gacccatgtt atgattcgct gtcaggaact gaaatacgac      540

gttggtggag gagaacggtt tgattctttg acagatcttg tggaacatta taagaagaat      600

cctatggtgg aaacattggg tacagtacta caactcaagc agccccttaa cacgactcgt      660

ataaatgctg ctgaaataga aagcagagtt cgagaactaa gcaaattagc tgagaccaca      720

gataaagtca aacaaggctt ttgggaagaa tttgagacac tacaacaaca ggagtgcaaa      780

cttctctaca gccgaaaaga gggtcaaagg caagaaaaca aaaacaaaaa tagatataaa      840

aacatcctgc cctttgatca taccagggtt gtcctacacg atggtgatcc caatgagcct      900

gtttcagatt acatcaatgc aaatatcatc atgcctgaat ttgaaaccaa gtgcaacaat      960

tcaaagccca aaaagagtta cattgccaca caaggctgcc tgcaaaacac ggtgaatgac     1020

ttttggcgga tggtgttcca agaaaactcc cgagtgattg tcatgacaac gaaagaagtg     1080

gagagaggaa agagtaaatg tgtcaaatac tggcctgatg agtatgctct aaaagaatat     1140

ggcgtcatgc gtgttaggaa cgtcaaagaa agcgccgctc atgactatac gctaagagaa     1200

cttaaacttt caaaggttgg acaagggaat acggagagaa cggtctggca ataccacttt     1260

cggacctggc cggaccacgg cgtgcccagc gaccctgggg gcgtgctgga cttcctggag     1320

gaggtgcacc ataagcagga gagcatcatg gatgcagggc cggtcgtggt gcactgcagg     1380

tga                                                                   1383


<210>  32
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Thr Ser Arg Arg Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala 
1               5                   10                  15      


Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg 
            20                  25                  30          


Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn 
        35                  40                  45              


Gly Ala Val Thr His Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp 
    50                  55                  60                  


Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr 
65                  70                  75                  80  


Tyr Met Glu His His Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile 
                85                  90                  95      


Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pro Thr Ser Glu Arg Trp 
            100                 105                 110         


Phe His Gly His Leu Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr Glu 
        115                 120                 125             


Lys Gly Lys His Gly Ser Phe Leu Val Arg Glu Ser Gln Ser His Pro 
    130                 135                 140                 


Gly Asp Phe Val Leu Ser Val Arg Thr Gly Asp Asp Lys Gly Glu Ser 
145                 150                 155                 160 


Asn Asp Gly Lys Ser Lys Val Thr His Val Met Ile Arg Cys Gln Glu 
                165                 170                 175     


Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr Asp 
            180                 185                 190         


Leu Val Glu His Tyr Lys Lys Asn Pro Met Val Glu Thr Leu Gly Thr 
        195                 200                 205             


Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Thr Arg Ile Asn Ala Ala 
    210                 215                 220                 


Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Lys Leu Ala Glu Thr Thr 
225                 230                 235                 240 


Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln 
                245                 250                 255     


Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu 
            260                 265                 270         


Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Thr 
        275                 280                 285             


Arg Val Val Leu His Asp Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr 
    290                 295                 300                 


Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Glu Thr Lys Cys Asn Asn 
305                 310                 315                 320 


Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn 
                325                 330                 335     


Thr Val Asn Asp Phe Trp Arg Met Val Phe Gln Glu Asn Ser Arg Val 
            340                 345                 350         


Ile Val Met Thr Thr Lys Glu Val Glu Arg Gly Lys Ser Lys Cys Val 
        355                 360                 365             


Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg 
    370                 375                 380                 


Val Arg Asn Val Lys Glu Ser Ala Ala His Asp Tyr Thr Leu Arg Glu 
385                 390                 395                 400 


Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Thr Glu Arg Thr Val Trp 
                405                 410                 415     


Gln Tyr His Phe Arg Thr Trp Pro Asp His Gly Val Pro Ser Asp Pro 
            420                 425                 430         


Gly Gly Val Leu Asp Phe Leu Glu Glu Val His His Lys Gln Glu Ser 
        435                 440                 445             


Ile Met Asp Ala Gly Pro Val Val Val His Cys Arg 
    450                 455                 460 


<210>  33
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Partial Homo sapiens 
       wild type Jak3 cDNA sequence encoding V722"

<400>  33
tgggaagtgt ttagtggcgt caccatgccc atcagtgccc tggat                       45


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Partial Homo sapiens 
       wild type Jak3 amino acid sequence encompassing V722"

<400>  34

Trp Glu Val Phe Ser Gly Val Thr Met Pro Ile Ser Ala Leu Asp 
1               5                   10                  15  


<210>  35
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Partial Homo sapiens 
       mutant Jak3 cDNA sequence encoding I722"

<400>  35
tgggaagtgt ttagtggcat caccatgccc atcagtgccc tggat                       45


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Partial Homo sapiens 
       mutant Jak3 amino acid sequence encompassing I722"

<400>  36

Trp Glu Val Phe Ser Gly Ile Thr Met Pro Ile Ser Ala Leu Asp 
1               5                   10                  15  


<210>  37
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Partial Homo sapiens 
       wild type Jak3 cDNA sequence encoding S61"

<400>  37
tgcgtgcagg ctgccaaggc cagcggtgag tgcatcccta gt                          42


<210>  38
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Partial Homo sapiens 
       wild type Jak3 amino acid sequence encompassing S61"

<400>  38

Cys Val Gln Ala Ala Lys Ala Ser Gly Glu Cys Ile Pro Ser 
1               5                   10                  


<210>  39
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Partial Homo sapiens 
       mutant Jak3 cDNA sequence encoding C61"

<400>  39
tgcgtgcagg ctgccaaggc ctgcggtgag tgcatcccta gt                          42


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Partial Homo sapiens 
       mutant Jak3 amino acid sequence encompassing C61"

<400>  40

Cys Val Gln Ala Ala Lys Ala Cys Gly Glu Cys Ile Pro Ser 
1               5                   10                  