                         SEQUENCE LISTING


<110>  The Trustees of Columbia University in the City of New York
 
<120>  MULTIVALENT RAS BINDING COMPOUNDS

<130>  C035795/0365302

<150>  US 62/005,831
<151>  2014-05-30

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  1061
<212>  DNA
<213>  Homo sapiens

<400>  1
tgccctgcgc ccgcaacccg agccgcaccc gccgcggacg gagcccatgc gcggggcgaa       60

ccgcgcgccc ccgcccccgc cccgccccgg cctcggcccc ggccctggcc ccgggggcag      120

tcgcgcctgt gaacggtggg gcaggagacc ctgtaggagg accccgggcc gcaggcccct      180

gaggagcgat gacggaatat aagctggtgg tggtgggcgc cggcggtgtg ggcaagagtg      240

cgctgaccat ccagctgatc cagaaccatt ttgtggacga atacgacccc actatagagg      300

attcctaccg gaagcaggtg gtcattgatg gggagacgtg cctgttggac atcctggata      360

ccgccggcca ggaggagtac agcgccatgc gggaccagta catgcgcacc ggggagggct      420

tcctgtgtgt gtttgccatc aacaacacca agtcttttga ggacatccac cagtacaggg      480

agcagatcaa acgggtgaag gactcggatg acgtgcccat ggtgctggtg gggaacaagt      540

gtgacctggc tgcacgcact gtggaatctc ggcaggctca ggacctcgcc cgaagctacg      600

gcatccccta catcgagacc tcggccaaga cccggcaggg agtggaggat gccttctaca      660

cgttggtgcg tgagatccgg cagcacaagc tgcggaagct gaaccctcct gatgagagtg      720

gccccggctg catgagctgc aagtgtgtgc tctcctgacg cagcacaagc tcaggacatg      780

gaggtgccgg atgcaggaag gaggtgcaga cggaaggagg aggaaggaag gacggaagca      840

aggaaggaag gaagggctgc tggagcccag tcaccccggg accgtgggcc gaggtgactg      900

cagaccctcc cagggaggct gtgcacagac tgtcttgaac atcccaaatg ccaccggaac      960

cccagccctt agctcccctc ccaggcctct gtgggccctt gtcgggcaca gatgggatca     1020

cagtaaatta ttggatggtc ttgaaaaaaa aaaaaaaaaa a                         1061


<210>  2
<211>  1251
<212>  DNA
<213>  Homo sapiens

<400>  2
tgccctgcgc ccgcaacccg agccgcaccc gccgcggacg gagcccatgc gcggggcgaa       60

ccgcgcgccc ccgcccccgc cccgccccgg cctcggcccc ggccctggcc ccgggggcag      120

tcgcgcctgt gaacggtggg gcaggagacc ctgtaggagg accccgggcc gcaggcccct      180

gaggagcgat gacggaatat aagctggtgg tggtgggcgc cggcggtgtg ggcaagagtg      240

cgctgaccat ccagctgatc cagaaccatt ttgtggacga atacgacccc actatagagg      300

attcctaccg gaagcaggtg gtcattgatg gggagacgtg cctgttggac atcctggata      360

ccgccggcca ggaggagtac agcgccatgc gggaccagta catgcgcacc ggggagggct      420

tcctgtgtgt gtttgccatc aacaacacca agtcttttga ggacatccac cagtacaggg      480

agcagatcaa acgggtgaag gactcggatg acgtgcccat ggtgctggtg gggaacaagt      540

gtgacctggc tgcacgcact gtggaatctc ggcaggctca ggacctcgcc cgaagctacg      600

gcatccccta catcgagacc tcggccaaga cccggcaggg cagccgctct ggctctagct      660

ccagctccgg gaccctctgg gaccccccgg gacccatgtg acccagcggc ccctcgcgct      720

ggagtggagg atgccttcta cacgttggtg cgtgagatcc ggcagcacaa gctgcggaag      780

ctgaaccctc ctgatgagag tggccccggc tgcatgagct gcaagtgtgt gctctcctga      840

cgcaggtgag ggggactccc agggcggccg ccacgcccac cggatgaccc cggctccccg      900

cccctgccgg tctcctggcc tgcggtcagc agcctccctt gtgccccgcc cagcacaagc      960

tcaggacatg gaggtgccgg atgcaggaag gaggtgcaga cggaaggagg aggaaggaag     1020

gacggaagca aggaaggaag gaagggctgc tggagcccag tcaccccggg accgtgggcc     1080

gaggtgactg cagaccctcc cagggaggct gtgcacagac tgtcttgaac atcccaaatg     1140

ccaccggaac cccagccctt agctcccctc ccaggcctct gtgggccctt gtcgggcaca     1200

gatgggatca cagtaaatta ttggatggtc ttgaaaaaaa aaaaaaaaaa a              1251


<210>  3
<211>  1169
<212>  DNA
<213>  Homo sapiens

<400>  3
tgccctgcgc ccgcaacccg agccgcaccc gccgcggacg gagcccatgc gcggggcgaa       60

ccgcgcgccc ccgcccccgc cccgccccgg cctcggcccc ggccctggcc ccgggggcag      120

tcgcgcctgt gaacggtggg gcaggagacc ctgtaggagg accccgggcc gcaggcccct      180

gaggagcgat gacggaatat aagctggtgg tggtgggcgc cggcggtgtg ggcaagagtg      240

cgctgaccat ccagctgatc cagaaccatt ttgtggacga atacgacccc actatagagg      300

attcctaccg gaagcaggtg gtcattgatg gggagacgtg cctgttggac atcctggata      360

ccgccggcca ggaggagtac agcgccatgc gggaccagta catgcgcacc ggggagggct      420

tcctgtgtgt gtttgccatc aacaacacca agtcttttga ggacatccac cagtacaggg      480

agcagatcaa acgggtgaag gactcggatg acgtgcccat ggtgctggtg gggaacaagt      540

gtgacctggc tgcacgcact gtggaatctc ggcaggctca ggacctcgcc cgaagctacg      600

gcatccccta catcgagacc tcggccaaga cccggcaggg agtggaggat gccttctaca      660

cgttggtgcg tgagatccgg cagcacaagc tgcggaagct gaaccctcct gatgagagtg      720

gccccggctg catgagctgc aagtgtgtgc tctcctgacg caggtgaggg ggactcccag      780

ggcggccgcc acgcccaccg gatgaccccg gctccccgcc cctgccggtc tcctggcctg      840

cggtcagcag cctcccttgt gccccgccca gcacaagctc aggacatgga ggtgccggat      900

gcaggaagga ggtgcagacg gaaggaggag gaaggaagga cggaagcaag gaaggaagga      960

agggctgctg gagcccagtc accccgggac cgtgggccga ggtgactgca gaccctccca     1020

gggaggctgt gcacagactg tcttgaacat cccaaatgcc accggaaccc cagcccttag     1080

ctcccctccc aggcctctgt gggcccttgt cgggcacaga tgggatcaca gtaaattatt     1140

ggatggtctt gaaaaaaaaa aaaaaaaaa                                       1169


<210>  4
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  5
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Ser Arg Ser Gly Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Gly Thr Leu Trp Asp Pro Pro Gly Pro Met 
                165                 170 


<210>  6
<211>  2043
<212>  DNA
<213>  Mus musculus

<400>  6
cgagcgcggg cccggccaag tccccgccgt ccgctcccgg cgcccgcagc ccgagccgca       60

cccgccgcgg acggagctca tgcgcgggcc cagccggcgc ccgtccgcgc ccccgccctg      120

ccccggcccc ggccccggcc ccgggggcag tcgcgccagc aagcggtggg gcaggagctc      180

ctggattggc agccgctgta gaagctatga cagaatacaa gcttgtggtg gtgggcgctg      240

gaggcgtggg aaagagtgcc ctgaccatcc agctgatcca gaaccacttt gtggacgagt      300

atgatcccac tatagaggac tcctaccgga aacaggtggt cattgatggg gagacatgtc      360

tactggacat cttagacaca gcaggtcaag aagagtatag tgccatgcgg gaccagtaca      420

tgcgcacagg ggagggcttc ctctgtgtat ttgccatcaa caacaccaag tccttcgagg      480

acatccatca gtacagggag cagatcaagc gggtgaaaga ttcagatgat gtgccaatgg      540

tgctggtggg caacaagtgt gacctggctg ctcgcactgt tgagtctcgg caggcccagg      600

accttgctcg cagctatggc atcccctaca ttgaaacatc agccaagacc cggcagggcg      660

tggaggatgc cttctataca ctagtccgtg agattcggca gcataaattg cggaaactga      720

acccacccga tgagagtggt cctggctgca tgagctgcaa atgtgtgctg tcctgacacc      780

aggctcagga catggaggtg ccggatgcag ggaggaggtg ccgacggaag gaaggaaaga      840

ggcgggaagg aaggaaacgg tgctggagcc aggccagtcc agggatggtg gacagatgtg      900

accaagacct tcgcatggac aatttgaaca gactgtcatg aactgtccct gttgccactg      960

gcacccaagt cctccacccc tctcagttcc ctccgggcgc ctgcctgtga gggcacacgt     1020

tgcatcacag taaattattt gatggtcttg acttgtctct ggctggaagt aggaggtgca     1080

ctgcctgtgg cctcacagaa gatgctgggc acctggggtc catcatctgc cttgctcctg     1140

tgctagaaga ggctggggag gctggcctgg gacctcggac tatacagccc ttcccttctg     1200

cctgtcccaa ctgtcttgtg tttgctgcag aaagttatag gcaacacaag gatagtcagg     1260

tgatatgacc tattgtcctt taactaatgg gaggaggagg gctctgagag taagagggta     1320

tcccttgtct ccagcaggaa acacatttcc tgcattctgg gatccatgaa atacagcctc     1380

aagagtgaca gagtgtaaga tttgccctga cccaacatcc tgcagccctc tgacctggga     1440

tggagattct aggactatgg aaatagggcc ctgatgttat ctgtgtagcc tcgggtccca     1500

ctggtgccta gggcctggca tcacaactcc ctgagagggt agaaagtgcc tcactggttg     1560

ctccctcttc tctgaggtgt acagatgttc ttctccaagt cacctgtatg gccttgagag     1620

gcacgtgcag gtcagatggc tgctcactgc gtgcttcctt ctggctctag tcatggctac     1680

aggagggtcc atctgcttat cctgctcctc ttcctggcca ctggggccca tggtgggtgc     1740

cctttatact ttccagactc gagtggaatt gggtgaagtc cctctgttta gggcacttga     1800

aatgcaagga gcctccaata gacatgatgt agagcctgct gctgagtggc tgggcagtgc     1860

gacaccacag ttgctctctt ccacagcagc caaatgttca gcttcccttg tctgtgtgta     1920

tctggggctc ctgaggtatc atctggagcg tcagtgacac cttcggagcc ttgttggtca     1980

tgaacttaag gtgggtggga gatagtgtct gctacactag gagttgtccc tggccctgtt     2040

tga                                                                   2043


<210>  7
<211>  2272
<212>  DNA
<213>  Mus musculus

<400>  7
cgagcgcggg cccggccaag tccccgccgt ccgctcccgg cgcccgcagc ccgagccgca       60

cccgccgcgg acggagctca tgcgcgggcc cagccggcgc ccgtccgcgc ccccgccctg      120

ccccggcccc ggccccggcc ccgggggcag tcgcgccagc aagcggtggg gcaggagctc      180

ctggattggc agccgctgta gaagctatga cagaatacaa gcttgtggtg gtgggcgctg      240

gaggcgtggg aaagagtgcc ctgaccatcc agctgatcca gaaccacttt gtggacgagt      300

atgatcccac tatagaggac tcctaccgga aacaggtggt cattgatggg gagacatgtc      360

tactggacat cttagacaca gcaggtcaag aagagtatag tgccatgcgg gaccagtaca      420

tgcgcacagg ggagggcttc ctctgtgtat ttgccatcaa caacaccaag tccttcgagg      480

acatccatca gtacagggag cagatcaagc gggtgaaaga ttcagatgat gtgccaatgg      540

tgctggtggg caacaagtgt gacctggctg ctcgcactgt tgagtctcgg caggcccagg      600

accttgctcg cagctatggc atcccctaca ttgaaacatc agccaagacc cggcagggca      660

gccgctctgg ctccagctcc gggaccctct gggatccccc ctcccccggg acccatgtga      720

cccagcggcc ctcaagctgg cgtggaggat gccttctata cactagtccg tgagattcgg      780

cagcataaat tgcggaaact gaacccaccc gatgagagtg gtcctggctg catgagctgc      840

aaatgtgtgc tgtcctgaca ccaggtgagg cagggaccag cgagacgtct ggggcagtga      900

cctcagctag ccagatgaac ttcatatcca ctctgatgtc cttgctcccc caattctgcc      960

aatccccccc gcctgcagtc agtcatgtcc tttgtgcccg tcccggcaca ggctcaggac     1020

atggaggtgc cggatgcagg gaggaggtgc cgacggaagg aaggaaagag gcgggaagga     1080

aggaaacggt gctggagcca ggccagtcca gggatggtgg acagatgtga ccaagacctt     1140

cgcatggaca atttgaacag actgtcatga actgtccctg ttgccactgg cacccaagtc     1200

ctccacccct ctcagttccc tccgggcgcc tgcctgtgag ggcacacgtt gcatcacagt     1260

aaattatttg atggtcttga cttgtctctg gctggaagta ggaggtgcac tgcctgtggc     1320

ctcacagaag atgctgggca cctggggtcc atcatctgcc ttgctcctgt gctagaagag     1380

gctggggagg ctggcctggg acctcggact atacagccct tcccttctgc ctgtcccaac     1440

tgtcttgtgt ttgctgcaga aagttatagg caacacaagg atagtcaggt gatatgacct     1500

attgtccttt aactaatggg aggaggaggg ctctgagagt aagagggtat cccttgtctc     1560

cagcaggaaa cacatttcct gcattctggg atccatgaaa tacagcctca agagtgacag     1620

agtgtaagat ttgccctgac ccaacatcct gcagccctct gacctgggat ggagattcta     1680

ggactatgga aatagggccc tgatgttatc tgtgtagcct cgggtcccac tggtgcctag     1740

ggcctggcat cacaactccc tgagagggta gaaagtgcct cactggttgc tccctcttct     1800

ctgaggtgta cagatgttct tctccaagtc acctgtatgg ccttgagagg cacgtgcagg     1860

tcagatggct gctcactgcg tgcttccttc tggctctagt catggctaca ggagggtcca     1920

tctgcttatc ctgctcctct tcctggccac tggggcccat ggtgggtgcc ctttatactt     1980

tccagactcg agtggaattg ggtgaagtcc ctctgtttag ggcacttgaa atgcaaggag     2040

cctccaatag acatgatgta gagcctgctg ctgagtggct gggcagtgcg acaccacagt     2100

tgctctcttc cacagcagcc aaatgttcag cttcccttgt ctgtgtgtat ctggggctcc     2160

tgaggtatca tctggagcgt cagtgacacc ttcggagcct tgttggtcat gaacttaagg     2220

tgggtgggag atagtgtctg ctacactagg agttgtccct ggccctgttt ga             2272


<210>  8
<211>  2190
<212>  DNA
<213>  Mus musculus

<400>  8
cgagcgcggg cccggccaag tccccgccgt ccgctcccgg cgcccgcagc ccgagccgca       60

cccgccgcgg acggagctca tgcgcgggcc cagccggcgc ccgtccgcgc ccccgccctg      120

ccccggcccc ggccccggcc ccgggggcag tcgcgccagc aagcggtggg gcaggagctc      180

ctggattggc agccgctgta gaagctatga cagaatacaa gcttgtggtg gtgggcgctg      240

gaggcgtggg aaagagtgcc ctgaccatcc agctgatcca gaaccacttt gtggacgagt      300

atgatcccac tatagaggac tcctaccgga aacaggtggt cattgatggg gagacatgtc      360

tactggacat cttagacaca gcaggtcaag aagagtatag tgccatgcgg gaccagtaca      420

tgcgcacagg ggagggcttc ctctgtgtat ttgccatcaa caacaccaag tccttcgagg      480

acatccatca gtacagggag cagatcaagc gggtgaaaga ttcagatgat gtgccaatgg      540

tgctggtggg caacaagtgt gacctggctg ctcgcactgt tgagtctcgg caggcccagg      600

accttgctcg cagctatggc atcccctaca ttgaaacatc agccaagacc cggcagggcg      660

tggaggatgc cttctataca ctagtccgtg agattcggca gcataaattg cggaaactga      720

acccacccga tgagagtggt cctggctgca tgagctgcaa atgtgtgctg tcctgacacc      780

aggtgaggca gggaccagcg agacgtctgg ggcagtgacc tcagctagcc agatgaactt      840

catatccact ctgatgtcct tgctccccca attctgccaa tcccccccgc ctgcagtcag      900

tcatgtcctt tgtgcccgtc ccggcacagg ctcaggacat ggaggtgccg gatgcaggga      960

ggaggtgccg acggaaggaa ggaaagaggc gggaaggaag gaaacggtgc tggagccagg     1020

ccagtccagg gatggtggac agatgtgacc aagaccttcg catggacaat ttgaacagac     1080

tgtcatgaac tgtccctgtt gccactggca cccaagtcct ccacccctct cagttccctc     1140

cgggcgcctg cctgtgaggg cacacgttgc atcacagtaa attatttgat ggtcttgact     1200

tgtctctggc tggaagtagg aggtgcactg cctgtggcct cacagaagat gctgggcacc     1260

tggggtccat catctgcctt gctcctgtgc tagaagaggc tggggaggct ggcctgggac     1320

ctcggactat acagcccttc ccttctgcct gtcccaactg tcttgtgttt gctgcagaaa     1380

gttataggca acacaaggat agtcaggtga tatgacctat tgtcctttaa ctaatgggag     1440

gaggagggct ctgagagtaa gagggtatcc cttgtctcca gcaggaaaca catttcctgc     1500

attctgggat ccatgaaata cagcctcaag agtgacagag tgtaagattt gccctgaccc     1560

aacatcctgc agccctctga cctgggatgg agattctagg actatggaaa tagggccctg     1620

atgttatctg tgtagcctcg ggtcccactg gtgcctaggg cctggcatca caactccctg     1680

agagggtaga aagtgcctca ctggttgctc cctcttctct gaggtgtaca gatgttcttc     1740

tccaagtcac ctgtatggcc ttgagaggca cgtgcaggtc agatggctgc tcactgcgtg     1800

cttccttctg gctctagtca tggctacagg agggtccatc tgcttatcct gctcctcttc     1860

ctggccactg gggcccatgg tgggtgccct ttatactttc cagactcgag tggaattggg     1920

tgaagtccct ctgtttaggg cacttgaaat gcaaggagcc tccaatagac atgatgtaga     1980

gcctgctgct gagtggctgg gcagtgcgac accacagttg ctctcttcca cagcagccaa     2040

atgttcagct tcccttgtct gtgtgtatct ggggctcctg aggtatcatc tggagcgtca     2100

gtgacacctt cggagccttg ttggtcatga acttaaggtg ggtgggagat agtgtctgct     2160

acactaggag ttgtccctgg ccctgtttga                                      2190


<210>  9
<211>  189
<212>  PRT
<213>  Mus musculus

<400>  9

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  10
<211>  188
<212>  PRT
<213>  Mus musculus

<400>  10

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Ser Arg Ser Gly Ser Ser Ser Gly Thr 
145                 150                 155                 160 


Leu Trp Asp Pro Pro Ser Pro Gly Thr His Val Thr Gln Arg Pro Ser 
                165                 170                 175     


Ser Trp Arg Gly Gly Cys Leu Leu Tyr Thr Ser Pro 
            180                 185             


<210>  11
<211>  1246
<212>  DNA
<213>  Rattus norvegicus

<400>  11
gcccggcgcc cgcagcccga gccgcacccg ccgcggacgg agcccatgcg cgggcccagt       60

cggcgcccgt ccgcgccccc gccctgcccc ggccccggcc ccgggggcag tcgcgccagc      120

aagcggtggg gcaggagctc ctggtttggc agcccctgta gaagcgatga cagaatacaa      180

gcttgtggtg gtgggcgctg gaggcgtggg aaagagtgcc ctgaccatcc agctgatcca      240

gaaccatttt gtggacgagt atgatcccac tatagaggac tcctaccgga aacaggtagt      300

cattgatggg gagacgtgtt tactggacat cttagacaca gcaggtcaag aagagtatag      360

tgccatgcgg gaccagtaca tgcgcacagg ggagggcttc ctctgtgtat ttgccatcaa      420

caacaccaag tcctttgaag acatccatca gtacagggag cagatcaagc gggtgaaaga      480

ttcagatgat gtgccaatgg tgctggtggg caacaagtgt gacctggccg ctcgcactgt      540

tgagtctcgg caggcccagg accttgctcg cagctatggc atcccctaca ttgaaacatc      600

agccaagacc cggcagggtg tggaggatgc cttctacaca ctagtacgtg agattcggca      660

gcataaactg cggaaactga acccgcctga tgagagtggc cctggctgca tgagctgcaa      720

gtgtgtgctg tcctgacacc aggctcagga cgaggaggtg ccggatgcag ggaggaggtg      780

ctgtcggaag gaaggaaaga ggagggaagg aaggaaacga tgctggagcc agtccagtcc      840

agggatggtg gacagatgtg accaagacct tcgcatggac aatttgaaca gactgtcatg      900

aactatccct gttgccactg gcacccaagt cctccgcccc tctcagctcc cttgggcgcc      960

tatgagggca catgttgaat cacagtaaat tatttgatgg tcttgacttg tctctggctg     1020

gaagtaggag gtgtagtgcc tgtggcctca cagaagatac tggggacctg ggatctatca     1080

tctgccttgt tcctgtttct agaagaggct ggggaggctg gcctgggacc tgggactgtg     1140

cagcccttct cttctgcctg cctcaactgt cttgtgtttc ctgcagaaag ttataaataa     1200

cacaagaata gtcaggtgat atgaaaaaaa aaaaaaaaaa aaaaaa                    1246


<210>  12
<211>  1392
<212>  DNA
<213>  Rattus norvegicus

<400>  12
gcccggcgcc cgcagcccga gccgcacccg ccgcggacgg agcccatgcg cgggcccagt       60

cggcgcccgt ccgcgccccc gccctgcccc ggccccggcc ccgggggcag tcgcgccagc      120

aagcggtggg gcaggagctc ctggtttggc agcccctgta gaagcgatga cagaatacaa      180

gcttgtggtg gtgggcgctg gaggcgtggg aaagagtgcc ctgaccatcc agctgatcca      240

gaaccatttt gtggacgagt atgatcccac tatagaggac tcctaccgga aacaggtagt      300

cattgatggg gagacgtgtt tactggacat cttagacaca gcaggtcaag aagagtatag      360

tgccatgcgg gaccagtaca tgcgcacagg ggagggcttc ctctgtgtat ttgccatcaa      420

caacaccaag tcctttgaag acatccatca gtacagggag cagatcaagc gggtgaaaga      480

ttcagatgat gtgccaatgg tgctggtggg caacaagtgt gacctggccg ctcgcactgt      540

tgagtctcgg caggcccagg accttgctcg cagctatggc atcccctaca ttgaaacatc      600

agccaagacc cggcagggtg tggaggatgc cttctacaca ctagtacgtg agattcggca      660

gcataaactg cggaaactga acccgcctga tgagagtggc cctggctgca tgagctgcaa      720

gtgtgtgctg tcctgacacc aggtgaggca gggaccagca agacatctgg ggcagtgacc      780

tcagctagcc agatgaactt catatccact ttgatgtccc tgctccccca attctgccaa      840

tccccctgcc tgcagtcagt catgtccttt gtgcccgtcc cggcacaggc tcaggacgag      900

gaggtgccgg atgcagggag gaggtgctgt cggaaggaag gaaagaggag ggaaggaagg      960

aaacgatgct ggagccagtc cagtccaggg atggtggaca gatgtgacca agaccttcgc     1020

atggacaatt tgaacagact gtcatgaact atccctgttg ccactggcac ccaagtcctc     1080

cgcccctctc agctcccttg ggcgcctatg agggcacatg ttgaatcaca gtaaattatt     1140

tgatggtctt gacttgtctc tggctggaag taggaggtgt agtgcctgtg gcctcacaga     1200

agatactggg gacctgggat ctatcatctg ccttgttcct gtttctagaa gaggctgggg     1260

aggctggcct gggacctggg actgtgcagc ccttctcttc tgcctgcctc aactgtcttg     1320

tgtttcctgc agaaagttat aaataacaca agaatagtca ggtgatatga aaaaaaaaaa     1380

aaaaaaaaaa aa                                                         1392


<210>  13
<211>  189
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  14
<211>  938
<212>  DNA
<213>  Canis lupus familiaris

<400>  14
agcaggtggg acaggagacc tcgttggcgt cctgtgctgc gtcccgtgag gagccatgac       60

ggagtataag ctggtggtgg tgggcgctgg aggcgtgggc aagagcgccc tgaccatcca      120

gctcatccag aaccacttcg tggatgagta cgaccccacc atcgaggact cctatcggaa      180

gcaagtggtc atcgacgggg agacgtgcct gctggacatc ctggacacag cgggccagga      240

ggagtacagc gccatgcggg accagtacat gcgcacgggg gagggctttc tctgtgtatt      300

tgccatcaac aacaccaagt cctttgagga catccaccag tacagggagc agatcaagcg      360

agtgaaggac tctgacgacg tgcccatggt gctggtgggg aacaagtgtg acctggctgc      420

tcgcaccgtg gagtcccggc aggcgcagga cctcgcccgc agctacggca tcccctacat      480

cgagacgtca gccaagacgc gccagggcgt ggaggatgcc ttctacacgc tggtgcgaga      540

gattcgacag cacaaggtgc gcaagctgag cccgcccgac gagggaggcc caggctgcat      600

gagctgcaag tgcctgctgt cctgacgtcc cctccagggc cacgttggca gccccgctgg      660

tcctctgtgc cccaggcgca caggctcggg gcgaggaggt gccggaagct gggaggaggc      720

gcggaaggag gaaggaggag ggcgaggaag gaaggaagcg cccccggggc ccggccagcc      780

caggccccct ggacaggggg agcacggacc tcccagggcg ctttgcacag actgtcgtga      840

actgaggcca cgggcccccc cggctgtcac tctcccccag tcccgtcctt gcccgcgggg      900

caaaggctga gtcgcagtaa attatttgat ggtcttga                              938


<210>  15
<211>  1020
<212>  DNA
<213>  Canis lupus familiaris

<400>  15
agcaggtggg acaggagacc tcgttggcgt cctgtgctgc gtcccgtgag gagccatgac       60

ggagtataag ctggtggtgg tgggcgctgg aggcgtgggc aagagcgccc tgaccatcca      120

gctcatccag aaccacttcg tggatgagta cgaccccacc atcgaggact cctatcggaa      180

gcaagtggtc atcgacgggg agacgtgcct gctggacatc ctggacacag cgggccagga      240

ggagtacagc gccatgcggg accagtacat gcgcacgggg gagggctttc tctgtgtatt      300

tgccatcaac aacaccaagt cctttgagga catccaccag tacagggagc agatcaagcg      360

agtgaaggac tctgacgacg tgcccatggt gctggtgggg aacaagtgtg acctggctgc      420

tcgcaccgtg gagtcccggc aggcgcagga cctcgcccgc agctacggca tcccctacat      480

cgagacgtca gccaagacgc gccagggcag ccggtctggc tctggctcca gctccgggac      540

cctctgggac cctccgggac ccccgtgacc cagcggcccc tagcgctggc gtggaggatg      600

ccttctacac gctggtgcga gagattcgac agcacaaggt gcgcaagctg agcccgcccg      660

acgagggagg cccaggctgc atgagctgca agtgcctgct gtcctgacgt cccctccagg      720

gccacgttgg cagccccgct ggtcctctgt gccccaggcg cacaggctcg gggcgaggag      780

gtgccggaag ctgggaggag gcgcggaagg aggaaggagg agggcgagga aggaaggaag      840

cgcccccggg gcccggccag cccaggcccc ctggacaggg ggagcacgga cctcccaggg      900

cgctttgcac agactgtcgt gaactgaggc cacgggcccc cccggctgtc actctccccc      960

agtcccgtcc ttgcccgcgg ggcaaaggct gagtcgcagt aaattatttg atggtcttga     1020


<210>  16
<211>  189
<212>  PRT
<213>  Canis lupus familiaris

<400>  16

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Val Arg Lys Leu Ser Pro Pro Asp Glu 
                165                 170                 175     


Gly Gly Pro Gly Cys Met Ser Cys Lys Cys Leu Leu Ser 
            180                 185                 


<210>  17
<211>  170
<212>  PRT
<213>  Canis lupus familiaris

<400>  17

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Ser Arg Ser Gly Ser Gly Ser Ser Ser 
145                 150                 155                 160 


Gly Thr Leu Trp Asp Pro Pro Gly Pro Pro 
                165                 170 


<210>  18
<211>  962
<212>  DNA
<213>  Gallus gallus

<400>  18
gggttgatgg ccggaccgtc gattccctga cgactacgag cacctacacc tgaggtggtg       60

gtgctcctgg aggccctgag ctggggtcag ctggaagatg accgagtaca agctggtggt      120

agtgggagct ggaggtgtcg ggaagagcgc tttgacgata cagctcattc agaaccattt      180

tgttgatgag tacgacccca caatagagga ttcctacaga aagcaagtcg tcatcgatgg      240

agagacctgt ttgctggaca tcctggatac ggcggggcag gaggagtaca gtgccatgcg      300

agaccagtac atgagaacgg gggaaggatt cctgtgcgtc tttgccatta acaacaccaa      360

gtcctttgag gacatccacc agtacaggga gcagatcaag agggtgaaag actcagatga      420

tgtccccatg gtgctggtgg gaaataaatg tgatctgcca gcacggacag tggagacccg      480

gcaagcgcag gacctggccc ggagttacgg gatcccctac atagaaacgt cggccaaaac      540

cagacagggc gtcgaagatg ccttctatac cttagtgcgg gagatccgtc agcataaact      600

gcgcaagctg aacccaccag atgagagtgg ccctggctgc atgaactgta aatgcgtgat      660

atcgtgactg tgctgactgg accctgactt ggagaggtgt ccgctgtgca gagcacaagg      720

aaagaggtga tgcgaaggaa gaaacaaatg gattcagggg aggagtggag ggggagggag      780

agaggaagaa gaggacggga ggagtgccag cccctccaag gactatctcg cacttcaccc      840

aggccggcag cagatgactt ttggttcttt ccccatcccc tcctcctttg gcctcctcca      900

ccccggcaac tgtacaaagc cacagattga atcacagtaa attattattt gatggtctcg      960

ac                                                                     962


<210>  19
<211>  189
<212>  PRT
<213>  Gallus gallus

<400>  19

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ala Arg Thr Val Glu Thr Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Asn Cys Lys Cys Val Ile Ser 
            180                 185                 


<210>  20
<211>  978
<212>  DNA
<213>  Bos taurus

<400>  20
ccgccgcgga cgggacccat gcgtcgggcg agccctgcgc cccggccccg gcccctgccg       60

ccgcccccgc tccggccccg gcccgggggg cagtcgagcc agtgagcggt gggaccggcg      120

accactgcag cgcctcgtgc tgcggtctct tgaggagcaa tgacggagta taagctcgtg      180

gtggtgggcg ccggtggcgt ggggaagagc gccctgacta tccagctcat tcagaatcac      240

ttcgtggacg agtacgaccc caccatcgag gactcctacc ggaagcaagt ggtcatcgat      300

ggggagacgt gcctgctgga catcctggac acagcgggcc aggaggaata cagcgccatg      360

cgagaccagt acatgcgcac cggggagggc tttctctgcg tgtttgctat caaccacgtc      420

aagtccttcg aggacatcca ccagtaccgg gagcagatca agcgggtgaa ggactcggat      480

gacgtgccca tggtgttggt tgggaacaag tgcgacctgg ccgcgcgcac cgtggagtct      540

cggcaggccc aggacctcgc ccgcagctac ggcatcccgt acatcgagac ctccgccaag      600

acccgccagg gcgtggagga tgctttctac accctggtgc gcgagatccg gcagcacaag      660

gtgcgcaagc tgagcccgcc ggacgagggc ggccccggct gcctgagctg caggtgcctg      720

ctctcctgac ggcagcgtgg gcgcggagcg ctgggtgcca tgcaggaggc ggcgcagcag      780

gggtggaggg aggtgccgcc agagcccagc cccccaggcc agtgggcagt gcccgcgggc      840

ctcccgggac gcttcgcaca gactctggtg aactgatgct gctggccccc agcctcgctc      900

tcctccagcc ctgtcctggc ccagcgggcg caggccgagt cgcagtaaat tatttcatgg      960

tcttgaaaaa aaaaaaaa                                                    978


<210>  21
<211>  1060
<212>  DNA
<213>  Bos taurus

<400>  21
ccgccgcgga cgggacccat gcgtcgggcg agccctgcgc cccggccccg gcccctgccg       60

ccgcccccgc tccggccccg gcccgggggg cagtcgagcc agtgagcggt gggaccggcg      120

accactgcag cgcctcgtgc tgcggtctct tgaggagcaa tgacggagta taagctcgtg      180

gtggtgggcg ccggtggcgt ggggaagagc gccctgacta tccagctcat tcagaatcac      240

ttcgtggacg agtacgaccc caccatcgag gactcctacc ggaagcaagt ggtcatcgat      300

ggggagacgt gcctgctgga catcctggac acagcgggcc aggaggaata cagcgccatg      360

cgagaccagt acatgcgcac cggggagggc tttctctgcg tgtttgctat caaccacgtc      420

aagtccttcg aggacatcca ccagtaccgg gagcagatca agcgggtgaa ggactcggat      480

gacgtgccca tggtgttggt tgggaacaag tgcgacctgg ccgcgcgcac cgtggagtct      540

cggcaggccc aggacctcgc ccgcagctac ggcatcccgt acatcgagac ctccgccaag      600

acccgccagg gcagccgctc tggctctggc tccagctccg ggaccctctg ggaccctccg      660

ggacccccgt gacccagccg cccctctcgc tggcgtggag gatgctttct acaccctggt      720

gcgcgagatc cggcagcaca aggtgcgcaa gctgagcccg ccggacgagg gcggccccgg      780

ctgcctgagc tgcaggtgcc tgctctcctg acggcagcgt gggcgcggag cgctgggtgc      840

catgcaggag gcggcgcagc aggggtggag ggaggtgccg ccagagccca gccccccagg      900

ccagtgggca gtgcccgcgg gcctcccggg acgcttcgca cagactctgg tgaactgatg      960

ctgctggccc ccagcctcgc tctcctccag ccctgtcctg gcccagcggg cgcaggccga     1020

gtcgcagtaa attatttcat ggtcttgaaa aaaaaaaaaa                           1060


<210>  22
<211>  189
<212>  PRT
<213>  Bos taurus

<400>  22

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn His Val Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Val Arg Lys Leu Ser Pro Pro Asp Glu 
                165                 170                 175     


Gly Gly Pro Gly Cys Leu Ser Cys Arg Cys Leu Leu Ser 
            180                 185                 


<210>  23
<211>  170
<212>  PRT
<213>  Bos taurus

<400>  23

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn His Val Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Ser Arg Ser Gly Ser Gly Ser Ser Ser 
145                 150                 155                 160 


Gly Thr Leu Trp Asp Pro Pro Gly Pro Pro 
                165                 170 


<210>  24
<211>  5889
<212>  DNA
<213>  Homo sapiens

<400>  24
tcctaggcgg cggccgcggc ggcggaggca gcagcggcgg cggcagtggc ggcggcgaag       60

gtggcggcgg ctcggccagt actcccggcc cccgccattt cggactggga gcgagcgcgg      120

cgcaggcact gaaggcggcg gcggggccag aggctcagcg gctcccaggt gcgggagaga      180

ggcctgctga aaatgactga atataaactt gtggtagttg gagctggtgg cgtaggcaag      240

agtgccttga cgatacagct aattcagaat cattttgtgg acgaatatga tccaacaata      300

gaggattcct acaggaagca agtagtaatt gatggagaaa cctgtctctt ggatattctc      360

gacacagcag gtcaagagga gtacagtgca atgagggacc agtacatgag gactggggag      420

ggctttcttt gtgtatttgc cataaataat actaaatcat ttgaagatat tcaccattat      480

agagaacaaa ttaaaagagt taaggactct gaagatgtac ctatggtcct agtaggaaat      540

aaatgtgatt tgccttctag aacagtagac acaaaacagg ctcaggactt agcaagaagt      600

tatggaattc cttttattga aacatcagca aagacaagac agagagtgga ggatgctttt      660

tatacattgg tgagggagat ccgacaatac agattgaaaa aaatcagcaa agaagaaaag      720

actcctggct gtgtgaaaat taaaaaatgc attataatgt aatctgggtg ttgatgatgc      780

cttctataca ttagttcgag aaattcgaaa acataaagaa aagatgagca aagatggtaa      840

aaagaagaaa aagaagtcaa agacaaagtg tgtaattatg taaatacaat ttgtactttt      900

ttcttaaggc atactagtac aagtggtaat ttttgtacat tacactaaat tattagcatt      960

tgttttagca ttacctaatt tttttcctgc tccatgcaga ctgttagctt ttaccttaaa     1020

tgcttatttt aaaatgacag tggaagtttt tttttcctct aagtgccagt attcccagag     1080

ttttggtttt tgaactagca atgcctgtga aaaagaaact gaatacctaa gatttctgtc     1140

ttggggtttt tggtgcatgc agttgattac ttcttatttt tcttaccaat tgtgaatgtt     1200

ggtgtgaaac aaattaatga agcttttgaa tcatccctat tctgtgtttt atctagtcac     1260

ataaatggat taattactaa tttcagttga gaccttctaa ttggttttta ctgaaacatt     1320

gagggaacac aaatttatgg gcttcctgat gatgattctt ctaggcatca tgtcctatag     1380

tttgtcatcc ctgatgaatg taaagttaca ctgttcacaa aggttttgtc tcctttccac     1440

tgctattagt catggtcact ctccccaaaa tattatattt tttctataaa aagaaaaaaa     1500

tggaaaaaaa ttacaaggca atggaaacta ttataaggcc atttcctttt cacattagat     1560

aaattactat aaagactcct aatagctttt cctgttaagg cagacccagt atgaaatggg     1620

gattattata gcaaccattt tggggctata tttacatgct actaaatttt tataataatt     1680

gaaaagattt taacaagtat aaaaaattct cataggaatt aaatgtagtc tccctgtgtc     1740

agactgctct ttcatagtat aactttaaat cttttcttca acttgagtct ttgaagatag     1800

ttttaattct gcttgtgaca ttaaaagatt atttgggcca gttatagctt attaggtgtt     1860

gaagagacca aggttgcaag gccaggccct gtgtgaacct ttgagctttc atagagagtt     1920

tcacagcatg gactgtgtcc ccacggtcat ccagtgttgt catgcattgg ttagtcaaaa     1980

tggggaggga ctagggcagt ttggatagct caacaagata caatctcact ctgtggtggt     2040

cctgctgaca aatcaagagc attgcttttg tttcttaaga aaacaaactc ttttttaaaa     2100

attactttta aatattaact caaaagttga gattttgggg tggtggtgtg ccaagacatt     2160

aatttttttt ttaaacaatg aagtgaaaaa gttttacaat ctctaggttt ggctagttct     2220

cttaacactg gttaaattaa cattgcataa acacttttca agtctgatcc atatttaata     2280

atgctttaaa ataaaaataa aaacaatcct tttgataaat ttaaaatgtt acttatttta     2340

aaataaatga agtgagatgg catggtgagg tgaaagtatc actggactag gaagaaggtg     2400

acttaggttc tagataggtg tcttttagga ctctgatttt gaggacatca cttactatcc     2460

atttcttcat gttaaaagaa gtcatctcaa actcttagtt tttttttttt acaactatgt     2520

aatttatatt ccatttacat aaggatacac ttatttgtca agctcagcac aatctgtaaa     2580

tttttaacct atgttacacc atcttcagtg ccagtcttgg gcaaaattgt gcaagaggtg     2640

aagtttatat ttgaatatcc attctcgttt taggactctt cttccatatt agtgtcatct     2700

tgcctcccta ccttccacat gccccatgac ttgatgcagt tttaatactt gtaattcccc     2760

taaccataag atttactgct gctgtggata tctccatgaa gttttcccac tgagtcacat     2820

cagaaatgcc ctacatctta tttcctcagg gctcaagaga atctgacaga taccataaag     2880

ggatttgacc taatcactaa ttttcaggtg gtggctgatg ctttgaacat ctctttgctg     2940

cccaatccat tagcgacagt aggatttttc aaacctggta tgaatagaca gaaccctatc     3000

cagtggaagg agaatttaat aaagatagtg ctgaaagaat tccttaggta atctataact     3060

aggactactc ctggtaacag taatacattc cattgtttta gtaaccagaa atcttcatgc     3120

aatgaaaaat actttaattc atgaagctta cttttttttt ttggtgtcag agtctcgctc     3180

ttgtcaccca ggctggaatg cagtggcgcc atctcagctc actgcaacct ccatctccca     3240

ggttcaagcg attctcgtgc ctcggcctcc tgagtagctg ggattacagg cgtgtgccac     3300

tacactcaac taatttttgt atttttagga gagacggggt ttcaccctgt tggccaggct     3360

ggtctcgaac tcctgacctc aagtgattca cccaccttgg cctcataaac ctgttttgca     3420

gaactcattt attcagcaaa tatttattga gtgcctacca gatgccagtc accgcacaag     3480

gcactgggta tatggtatcc ccaaacaaga gacataatcc cggtccttag gtagtgctag     3540

tgtggtctgt aatatcttac taaggccttt ggtatacgac ccagagataa cacgatgcgt     3600

attttagttt tgcaaagaag gggtttggtc tctgtgccag ctctataatt gttttgctac     3660

gattccactg aaactcttcg atcaagctac tttatgtaaa tcacttcatt gttttaaagg     3720

aataaacttg attatattgt ttttttattt ggcataactg tgattctttt aggacaatta     3780

ctgtacacat taaggtgtat gtcagatatt catattgacc caaatgtgta atattccagt     3840

tttctctgca taagtaatta aaatatactt aaaaattaat agttttatct gggtacaaat     3900

aaacaggtgc ctgaactagt tcacagacaa ggaaacttct atgtaaaaat cactatgatt     3960

tctgaattgc tatgtgaaac tacagatctt tggaacactg tttaggtagg gtgttaagac     4020

ttacacagta cctcgtttct acacagagaa agaaatggcc atacttcagg aactgcagtg     4080

cttatgaggg gatatttagg cctcttgaat ttttgatgta gatgggcatt tttttaaggt     4140

agtggttaat tacctttatg tgaactttga atggtttaac aaaagatttg tttttgtaga     4200

gattttaaag ggggagaatt ctagaaataa atgttaccta attattacag ccttaaagac     4260

aaaaatcctt gttgaagttt ttttaaaaaa agctaaatta catagactta ggcattaaca     4320

tgtttgtgga agaatatagc agacgtatat tgtatcattt gagtgaatgt tcccaagtag     4380

gcattctagg ctctatttaa ctgagtcaca ctgcatagga atttagaacc taacttttat     4440

aggttatcaa aactgttgtc accattgcac aattttgtcc taatatatac atagaaactt     4500

tgtggggcat gttaagttac agtttgcaca agttcatctc atttgtattc cattgatttt     4560

ttttttcttc taaacatttt ttcttcaaac agtatataac tttttttagg ggattttttt     4620

ttagacagca aaaactatct gaagatttcc atttgtcaaa aagtaatgat ttcttgataa     4680

ttgtgtagta atgtttttta gaacccagca gttaccttaa agctgaattt atatttagta     4740

acttctgtgt taatactgga tagcatgaat tctgcattga gaaactgaat agctgtcata     4800

aaatgaaact ttctttctaa agaaagatac tcacatgagt tcttgaagaa tagtcataac     4860

tagattaaga tctgtgtttt agtttaatag tttgaagtgc ctgtttggga taatgatagg     4920

taatttagat gaatttaggg gaaaaaaaag ttatctgcag atatgttgag ggcccatctc     4980

tccccccaca cccccacaga gctaactggg ttacagtgtt ttatccgaaa gtttccaatt     5040

ccactgtctt gtgttttcat gttgaaaata cttttgcatt tttcctttga gtgccaattt     5100

cttactagta ctatttctta atgtaacatg tttacctgga atgtatttta actatttttg     5160

tatagtgtaa actgaaacat gcacattttg tacattgtgc tttcttttgt gggacatatg     5220

cagtgtgatc cagttgtttt ccatcatttg gttgcgctga cctaggaatg ttggtcatat     5280

caaacattaa aaatgaccac tcttttaatt gaaattaact tttaaatgtt tataggagta     5340

tgtgctgtga agtgatctaa aatttgtaat atttttgtca tgaactgtac tactcctaat     5400

tattgtaatg taataaaaat agttacagtg actatgagtg tgtatttatt catgaaattt     5460

gaactgtttg ccccgaaatg gatatggaat actttataag ccatagacac tatagtatac     5520

cagtgaatct tttatgcagc ttgttagaag tatcctttat ttctaaaagg tgctgtggat     5580

attatgtaaa ggcgtgtttg cttaaactta aaaccatatt tagaagtaga tgcaaaacaa     5640

atctgccttt atgacaaaaa aataggataa cattatttat ttatttcctt ttatcaaaga     5700

aggtaattga tacacaacag gtgacttggt tttaggccca aaggtagcag cagcaacatt     5760

aataatggaa ataattgaat agttagttat gtatgttaat gccagtcacc agcaggctat     5820

ttcaaggtca gaagtaatga ctccatacat attatttatt tctataacta catttaaatc     5880

attaccagg                                                             5889


<210>  25
<211>  5765
<212>  DNA
<213>  Homo sapiens

<400>  25
tcctaggcgg cggccgcggc ggcggaggca gcagcggcgg cggcagtggc ggcggcgaag       60

gtggcggcgg ctcggccagt actcccggcc cccgccattt cggactggga gcgagcgcgg      120

cgcaggcact gaaggcggcg gcggggccag aggctcagcg gctcccaggt gcgggagaga      180

ggcctgctga aaatgactga atataaactt gtggtagttg gagctggtgg cgtaggcaag      240

agtgccttga cgatacagct aattcagaat cattttgtgg acgaatatga tccaacaata      300

gaggattcct acaggaagca agtagtaatt gatggagaaa cctgtctctt ggatattctc      360

gacacagcag gtcaagagga gtacagtgca atgagggacc agtacatgag gactggggag      420

ggctttcttt gtgtatttgc cataaataat actaaatcat ttgaagatat tcaccattat      480

agagaacaaa ttaaaagagt taaggactct gaagatgtac ctatggtcct agtaggaaat      540

aaatgtgatt tgccttctag aacagtagac acaaaacagg ctcaggactt agcaagaagt      600

tatggaattc cttttattga aacatcagca aagacaagac agggtgttga tgatgccttc      660

tatacattag ttcgagaaat tcgaaaacat aaagaaaaga tgagcaaaga tggtaaaaag      720

aagaaaaaga agtcaaagac aaagtgtgta attatgtaaa tacaatttgt acttttttct      780

taaggcatac tagtacaagt ggtaattttt gtacattaca ctaaattatt agcatttgtt      840

ttagcattac ctaatttttt tcctgctcca tgcagactgt tagcttttac cttaaatgct      900

tattttaaaa tgacagtgga agtttttttt tcctctaagt gccagtattc ccagagtttt      960

ggtttttgaa ctagcaatgc ctgtgaaaaa gaaactgaat acctaagatt tctgtcttgg     1020

ggtttttggt gcatgcagtt gattacttct tatttttctt accaattgtg aatgttggtg     1080

tgaaacaaat taatgaagct tttgaatcat ccctattctg tgttttatct agtcacataa     1140

atggattaat tactaatttc agttgagacc ttctaattgg tttttactga aacattgagg     1200

gaacacaaat ttatgggctt cctgatgatg attcttctag gcatcatgtc ctatagtttg     1260

tcatccctga tgaatgtaaa gttacactgt tcacaaaggt tttgtctcct ttccactgct     1320

attagtcatg gtcactctcc ccaaaatatt atattttttc tataaaaaga aaaaaatgga     1380

aaaaaattac aaggcaatgg aaactattat aaggccattt ccttttcaca ttagataaat     1440

tactataaag actcctaata gcttttcctg ttaaggcaga cccagtatga aatggggatt     1500

attatagcaa ccattttggg gctatattta catgctacta aatttttata ataattgaaa     1560

agattttaac aagtataaaa aattctcata ggaattaaat gtagtctccc tgtgtcagac     1620

tgctctttca tagtataact ttaaatcttt tcttcaactt gagtctttga agatagtttt     1680

aattctgctt gtgacattaa aagattattt gggccagtta tagcttatta ggtgttgaag     1740

agaccaaggt tgcaaggcca ggccctgtgt gaacctttga gctttcatag agagtttcac     1800

agcatggact gtgtccccac ggtcatccag tgttgtcatg cattggttag tcaaaatggg     1860

gagggactag ggcagtttgg atagctcaac aagatacaat ctcactctgt ggtggtcctg     1920

ctgacaaatc aagagcattg cttttgtttc ttaagaaaac aaactctttt ttaaaaatta     1980

cttttaaata ttaactcaaa agttgagatt ttggggtggt ggtgtgccaa gacattaatt     2040

ttttttttaa acaatgaagt gaaaaagttt tacaatctct aggtttggct agttctctta     2100

acactggtta aattaacatt gcataaacac ttttcaagtc tgatccatat ttaataatgc     2160

tttaaaataa aaataaaaac aatccttttg ataaatttaa aatgttactt attttaaaat     2220

aaatgaagtg agatggcatg gtgaggtgaa agtatcactg gactaggaag aaggtgactt     2280

aggttctaga taggtgtctt ttaggactct gattttgagg acatcactta ctatccattt     2340

cttcatgtta aaagaagtca tctcaaactc ttagtttttt ttttttacaa ctatgtaatt     2400

tatattccat ttacataagg atacacttat ttgtcaagct cagcacaatc tgtaaatttt     2460

taacctatgt tacaccatct tcagtgccag tcttgggcaa aattgtgcaa gaggtgaagt     2520

ttatatttga atatccattc tcgttttagg actcttcttc catattagtg tcatcttgcc     2580

tccctacctt ccacatgccc catgacttga tgcagtttta atacttgtaa ttcccctaac     2640

cataagattt actgctgctg tggatatctc catgaagttt tcccactgag tcacatcaga     2700

aatgccctac atcttatttc ctcagggctc aagagaatct gacagatacc ataaagggat     2760

ttgacctaat cactaatttt caggtggtgg ctgatgcttt gaacatctct ttgctgccca     2820

atccattagc gacagtagga tttttcaaac ctggtatgaa tagacagaac cctatccagt     2880

ggaaggagaa tttaataaag atagtgctga aagaattcct taggtaatct ataactagga     2940

ctactcctgg taacagtaat acattccatt gttttagtaa ccagaaatct tcatgcaatg     3000

aaaaatactt taattcatga agcttacttt ttttttttgg tgtcagagtc tcgctcttgt     3060

cacccaggct ggaatgcagt ggcgccatct cagctcactg caacctccat ctcccaggtt     3120

caagcgattc tcgtgcctcg gcctcctgag tagctgggat tacaggcgtg tgccactaca     3180

ctcaactaat ttttgtattt ttaggagaga cggggtttca ccctgttggc caggctggtc     3240

tcgaactcct gacctcaagt gattcaccca ccttggcctc ataaacctgt tttgcagaac     3300

tcatttattc agcaaatatt tattgagtgc ctaccagatg ccagtcaccg cacaaggcac     3360

tgggtatatg gtatccccaa acaagagaca taatcccggt ccttaggtag tgctagtgtg     3420

gtctgtaata tcttactaag gcctttggta tacgacccag agataacacg atgcgtattt     3480

tagttttgca aagaaggggt ttggtctctg tgccagctct ataattgttt tgctacgatt     3540

ccactgaaac tcttcgatca agctacttta tgtaaatcac ttcattgttt taaaggaata     3600

aacttgatta tattgttttt ttatttggca taactgtgat tcttttagga caattactgt     3660

acacattaag gtgtatgtca gatattcata ttgacccaaa tgtgtaatat tccagttttc     3720

tctgcataag taattaaaat atacttaaaa attaatagtt ttatctgggt acaaataaac     3780

aggtgcctga actagttcac agacaaggaa acttctatgt aaaaatcact atgatttctg     3840

aattgctatg tgaaactaca gatctttgga acactgttta ggtagggtgt taagacttac     3900

acagtacctc gtttctacac agagaaagaa atggccatac ttcaggaact gcagtgctta     3960

tgaggggata tttaggcctc ttgaattttt gatgtagatg ggcatttttt taaggtagtg     4020

gttaattacc tttatgtgaa ctttgaatgg tttaacaaaa gatttgtttt tgtagagatt     4080

ttaaaggggg agaattctag aaataaatgt tacctaatta ttacagcctt aaagacaaaa     4140

atccttgttg aagttttttt aaaaaaagct aaattacata gacttaggca ttaacatgtt     4200

tgtggaagaa tatagcagac gtatattgta tcatttgagt gaatgttccc aagtaggcat     4260

tctaggctct atttaactga gtcacactgc ataggaattt agaacctaac ttttataggt     4320

tatcaaaact gttgtcacca ttgcacaatt ttgtcctaat atatacatag aaactttgtg     4380

gggcatgtta agttacagtt tgcacaagtt catctcattt gtattccatt gatttttttt     4440

ttcttctaaa cattttttct tcaaacagta tataactttt tttaggggat ttttttttag     4500

acagcaaaaa ctatctgaag atttccattt gtcaaaaagt aatgatttct tgataattgt     4560

gtagtaatgt tttttagaac ccagcagtta ccttaaagct gaatttatat ttagtaactt     4620

ctgtgttaat actggatagc atgaattctg cattgagaaa ctgaatagct gtcataaaat     4680

gaaactttct ttctaaagaa agatactcac atgagttctt gaagaatagt cataactaga     4740

ttaagatctg tgttttagtt taatagtttg aagtgcctgt ttgggataat gataggtaat     4800

ttagatgaat ttaggggaaa aaaaagttat ctgcagatat gttgagggcc catctctccc     4860

cccacacccc cacagagcta actgggttac agtgttttat ccgaaagttt ccaattccac     4920

tgtcttgtgt tttcatgttg aaaatacttt tgcatttttc ctttgagtgc caatttctta     4980

ctagtactat ttcttaatgt aacatgttta cctggaatgt attttaacta tttttgtata     5040

gtgtaaactg aaacatgcac attttgtaca ttgtgctttc ttttgtggga catatgcagt     5100

gtgatccagt tgttttccat catttggttg cgctgaccta ggaatgttgg tcatatcaaa     5160

cattaaaaat gaccactctt ttaattgaaa ttaactttta aatgtttata ggagtatgtg     5220

ctgtgaagtg atctaaaatt tgtaatattt ttgtcatgaa ctgtactact cctaattatt     5280

gtaatgtaat aaaaatagtt acagtgacta tgagtgtgta tttattcatg aaatttgaac     5340

tgtttgcccc gaaatggata tggaatactt tataagccat agacactata gtataccagt     5400

gaatctttta tgcagcttgt tagaagtatc ctttatttct aaaaggtgct gtggatatta     5460

tgtaaaggcg tgtttgctta aacttaaaac catatttaga agtagatgca aaacaaatct     5520

gcctttatga caaaaaaata ggataacatt atttatttat ttccttttat caaagaaggt     5580

aattgataca caacaggtga cttggtttta ggcccaaagg tagcagcagc aacattaata     5640

atggaaataa ttgaatagtt agttatgtat gttaatgcca gtcaccagca ggctatttca     5700

aggtcagaag taatgactcc atacatatta tttatttcta taactacatt taaatcatta     5760

ccagg                                                                 5765


<210>  26
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  27
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  28
<211>  4670
<212>  DNA
<213>  Mus musculus

<400>  28
aggcggcggc cgcggcggct gaggcggcag cgctgtggcg gcggctgaga cggcagggga       60

aggcggcggc ggctcggccc ggagtcccgc tcccgcgcca tttcggaccc ggagcgagcg      120

cggcgcgggc ctgaaggcgg cggcgggagc ctgaggcgcg gcggctccgc ggcgcggaga      180

gaggcctgct gaaaatgact gagtataaac ttgtggtggt tggagctggt ggcgtaggca      240

agagcgcctt gacgatacag ctaattcaga atcactttgt ggatgagtat gaccctacga      300

tagaggactc ctacaggaaa caagtagtaa ttgatggaga aacctgtctc ttggatattc      360

tcgacacagc aggtcaagag gagtacagtg caatgaggga ccagtacatg agaactgggg      420

agggctttct ttgtgtattt gccataaata atactaaatc atttgaagat attcaccatt      480

atagagaaca aattaaaaga gtaaaggact ctgaagatgt gcctatggtc ctggtaggga      540

ataagtgtga tttgccttct agaacagtag acacgaaaca ggctcaggag ttagcaagga      600

gttacgggat tccgttcatt gagacctcag caaagacaag acagggtgtt gacgatgcct      660

tctatacatt agtccgagaa attcgaaaac ataaagaaaa gatgagcaaa gatgggaaga      720

agaagaagaa gaagtcaagg acaaggtgta cagttatgtg aatactttgt actctttctt      780

aaggcacact taagtaaaag tgtgattttt gtacattaca ctaaattatt agcatttgtt      840

ttagcattac ctaatctttt tttttcttct gttcgtgcaa actgtcagct tttatctcaa      900

atgcttattt taaaagaaca gtggaaacct tcttttttct aagtgccagt attccctggg      960

ttttggactt aaactagcaa tgcctgtgga agagactaaa gacctgagac tctgtcttgg     1020

gatttggtgc atgcagttga ttccttgcta gttctcttac caactgtgaa cactgatggg     1080

aagcaggata atgaagcttc cggaccatcc ctgctctgtg tccatctact catccaatgg     1140

agtcattagc agtcaatcgc cgcttcactg gacactgagg ggtcacagac ttaggctccc     1200

tttgagtcgc gtccagcgtg tcctagactt tatcatcttt cagaggcgta ggcagactgt     1260

tcacaaaggc tttctgtagc tttccactgc aattaatctt ggtcactccc tcaaatagta     1320

tattttttct agaaaagggg aaaaatggaa aaaaaaaggc aatggaaaat gttgaaatcc     1380

attcagtttc catgttagct aaattactgt aagattccta taatagcttt tcctggtaag     1440

gcagacccag tatgaaatag taataaccat ttgggctata tttacatgct actaaatttt     1500

tgtaataatt caaacaactt tagcatatat aaaaagttct cataagaatt aagtacaatt     1560

cccctttgtc agattgttct tatcctaact ttcaagtctt ttttgaattt ctgttgttga     1620

aagtagtttt aatggttgtg aagctgaaga tgatctgaga cagttatagc ttggcaggtg     1680

ttgaggagac cagagttgca gggttgggcc ttacgtgaac ctgtgacgaa cgctactggg     1740

ttttgcagca ctgctgcatt caatgttggc gacgcattgt ttggtcaaca taggggataa     1800

ggagactttg atggcttagt ataatgcatt ctcaccatgt aacagtccta ctgacaaatc     1860

aagaaatttg tttataataa taaaaaattt ttaaaaattt cgatgttcgc ttcaaggttg     1920

agattttggg gtaggaggct acaacaagag taaatcttaa agcaaggttt taagaaggtt     1980

tgaaaatgca ggtttgacta gtctctcaac tctagctaaa caaacattcc caagtacttc     2040

ccaaatctga taggtattta aaattatcta atgctttaag aatagttaac aggaaaaaaa     2100

tctcctcagt gcacttaaag caacccttca catcatttga aatgagatgg aaatatcact     2160

ggactatgag gactggatgt ctgtctgatt ttaagcaaat cactgtctgc ttggttttga     2220

atcatctcaa agacattaac ctcccagccg tgtaacatag tttacatgtt gacacaccta     2280

gttatcaagc tcagcacaat ctgtaactgt tttacatgga ttaacatctt cactgccagt     2340

cttgggcaaa ttgtgcaaga ggtaaaattt atatttcagt atccattctc ccatttcagg     2400

actcccctcc aacattatgc tggctttcag cctgtctctc acctgcccat cacttagtgt     2460

agttttaata atttccccca cttcaaactt tgtttccact atggacaact tcatgaactt     2520

tgcccactaa ggtaggtaca tcaaagctgc cctatggctt tcttccccgg gactgaaaat     2580

aacagacacc atagtgggat ttaaactaat agatggtttt cagggccact acaacaattc     2640

aatctcaatc ctttggactt cattcctgct gcccaggcca ctggtgcctc agtaggaatt     2700

ttcaaaatta gtgtgaacag acagagcaca gtccagtgga aggtgagctt aatcttcatc     2760

tagccatcat catggtaagt gatagattct attgttttaa taaatacagt ctaacaatga     2820

aaaacacttc gaagtttcaa tcataaagct gtctttttaa aaattttatt tactcaacat     2880

ttattcagtg cttgtcatat tctgggaatt acactaggca ctcagggtgc ggtgtcctca     2940

atccttggcc agtggtatgt agcatgatct gtaataccac taaataaggc atatagcata     3000

tgacttagac ataatgaaat acatgatttg agttttgcag agaggagttt gggtttgtac     3060

attcccttcc cccccagttt agcaagaatt gtttgctgtg aatccaatgc aacttttaaa     3120

tcaaactact ttatataatt atttcatttt tctaaaggaa cagaagtacc ctaaactatt     3180

tttttgaaat gttctaaact gtacatattc atagaacatt ctttgggtga attttaagtc     3240

ttaaaatgca attagtaata cttctcattt ctattcagag gaacaggtgt acttcaaaag     3300

ctgcagtgta taatcagata tttttaatgg acaatgtgtt aaagaagtgg taattaccac     3360

tatgtaaatt tgaattgtgt tacactttgg ttaacaaaag gggaaagaat cctagaaaca     3420

aatatgttat ctagttactg cagccttaaa gtccttgttg aagttaaaaa gcaatgctaa     3480

gttacagtca taggcattaa catgtttatg ggaaggatat agtaggcaaa tacaatttga     3540

gtaaatattt tcagtaggga attttaggct ctactgactg agtcacactg cataggaatt     3600

tagatcttaa cttttatagg ttatcgacct ttgccaccat tgcacaattt tgtcctaaca     3660

taaatacaag ttctgtgagg catgtcaaaa gttacagttt gcataaattc atctcatttt     3720

gtattccact gattttacat tttcctcaaa catacataca tacatacata caacacacac     3780

acactcacac atgaagggtt ttttttttgt aggcaataaa aatttaacta atttccattt     3840

gttaaaaagt agtgatttat tgagaattat gcagtcattt tttaaaccca aaagttattt     3900

aaaggtgaat ttatactcaa taacttctgt gtaatactgg gtagcatgaa ttctgcattg     3960

aaaaattgaa cagataatac caatagctgt aaattctgtc aaaacatgaa aattatttct     4020

aaagaagtac attagttttc aaagaacagt tattagaatc agatctgtgg tttagttcaa     4080

taatttgaag tgcctgtttg ggatggtggt aggcatttta gatgaatttg ggaaaaataa     4140

agttctgcag aaatgccagt ttcagacccc gctaacccgc tgagtgggct gtgtgctgtg     4200

ttagctccag tgccccaatc ccgtttcatg tcttcatgtt gaaacacttc tgcattttta     4260

tttgagtgcc aatttcttac tagtgctatt tcttagtgta acatgtttac ctgggatgta     4320

ttttaactat ttttgtatag tgtaaactga aacatgcaca ttttgtacat tgtgctttcc     4380

ttctttccat tccttttctt tctgttttgt ttgtttgttt gtttgtttgt ttgttatggg     4440

acatatgcag tgtgatccag ttgttttcca tcctttggtt gcgctgacct agggaatgtt     4500

ggtcatatca aacattaaat ttaaaagtga ccactcttaa ttaaaattaa cttttaaatg     4560

tttataggag tacgtgctgt gaagtgatct gaaatttgta atatttttgt catgaaccgt     4620

actgctccta atcattgtaa tgtaataaaa atagttatgg tgactatgaa                4670


<210>  29
<211>  188
<212>  PRT
<213>  Mus musculus

<400>  29

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Arg Thr Arg Cys Thr Val Met 
            180                 185             


<210>  30
<211>  661
<212>  DNA
<213>  Rattus norvegicus

<400>  30
atgactgagt ataaacttgt ggtagttgga gctggtggcg taggcaagag tgccttgacg       60

atacagctaa ttcagaatca ctttgtggat gaatatgatc ctacgataga ggactcctac      120

aggaaacaag tagtaattga tggagaaacc tgtctcttgg atattctcga cacagcaggt      180

caagaggagt acagtgcaat gagggaccag tacatgagaa ctggggaggg ctttctttgt      240

gtatttgcca taaataatac taaatcattt gaagatattc accattatag agaacaaatt      300

aaaagagtaa aggactctga agatgtgcct atggtcctag tagggaataa gtgtgacttg      360

ccttctagaa cagtagacac gaaacaggct caggagttag caaggagtta tgggattcca      420

ttcattgaga cctcagcgaa gacaagacag ggtgttgacg atgccttcta tacattagtc      480

cgagaaattc gaaaacataa agaaaagatg agcaaagatg ggaaaaagaa gaagaagaag      540

tcaaggacaa ggtgtatagt catgtgaata gtttgtactc tttcttaagg cacacttaag      600

taaagtgtga tttttgtaca ttacactaaa ttattagcat ttgttttagc attacctaat      660

c                                                                      661


<210>  31
<211>  188
<212>  PRT
<213>  Rattus norvegicus

<400>  31

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Arg Thr Arg Cys Ile Val Met 
            180                 185             


<210>  32
<211>  4993
<212>  DNA
<213>  Canis lupus familiaris

<400>  32
gctgaaaatg actgaatata aacttgtggt agttggagct ggtggcgtag gcaagagtgc       60

cttgacgata cagctaattc agaatcactt tgtggatgaa tatgatccta caatagagga      120

ttcctacagg aaacaagtag taattgatgg agaaacctgt ctcttggata ttctcgacac      180

agcaggtcaa gaggagtaca gtgcaatgag ggaccagtac atgaggactg gggagggctt      240

tctttgtgta tttgccataa ataatactaa atcatttgaa gatattcacc attatagaga      300

acaaattaaa agagttaaag actctgaaga tgtacctatg gtcctagtag gaaataaatg      360

tgatttgcct tctagaacag tagacacaaa acaggctcag gacttagcaa gaagttatgg      420

aattcctttt attgaaacat cagcaaagac aagacagaga gtggaggatg ctttttatac      480

attggtgaga gagatccgac aatacagatt gaaaaaaatc aacaaagaag aaaagactcc      540

tggctgtgtg aaaattaaaa aatgcattgt aatgggtgtt gacgatgcct tctatacatt      600

agttcgagaa attcgaaaac ataaagaaaa gatgagcaaa gatggtaaaa agaagaaaaa      660

gaagtcaaag acaaagtgta taattatgta aatacaattt gtactttttt cttaaggcat      720

acttaagtaa aagtggtaat ttttgtacat tacactaaat tattagcatt tgttttagca      780

ttacctaatt ttctgctcca tccaaactgt tagcttttat cttgaatgct tattttaaaa      840

tgacagtgga aactttttcc tctaagtgcc agtattccct gagttttggt tttgaactag      900

caatgcctgt gaaaaagaaa ctgaatacct gagatttctg tcttggggtt tttggtgcat      960

gcagttgatt acttcctatt tttcttacca attgtgaact ttggtgtgaa acaaattaat     1020

gaagctttcg aatcatccct attctgtgtt ttacctagtc acatacatgg attaattact     1080

aattataact tcagttgata tttcatgatt ggttttactg aaacattgag ggaacatgaa     1140

tttatgggct gcttcttata ggtataatgt cctatagttt cagtcaccct taatgaatgt     1200

aaagctacac tgttcacaaa ggttttctcc atcttttcac tgctatttgt catagccacg     1260

ctcccaaaaa tattatattt tttctataaa aaagggaaaa aatagaaaaa aatacaaggc     1320

aatggaaaat attaaaaggc atttactttc catattagat aaattcctat aatactctga     1380

atagcttttc ctgttaaggc agacccagta tgtaatgagg attatagcaa ccattttggg     1440

gctatattta catgctacta aatttttgta ttaattgaaa aagttttaac atgtataaaa     1500

aattcccata ggaattaaat atagtctccc tgtgtcagat tgctctttct tagcataact     1560

ttaaatcttt tcttgatctt caatcttaga aaatagtttt aattcttgta gtgatgttaa     1620

agattatttg ggccagttag tttttaatag atgttaaaga gaccacagtt ccaaggccag     1680

gccttgtgtg aacctttaag cttcattaag agtttcatag tacagactgc atccctgtgg     1740

tctcccaggg tcatcatgca ttgattgggt ggtcaaaagt ggggacaaag agtgtttaga     1800

taagatgcat cctcactgta tggtggtcct gctgacagat caggaccatc acttttgttt     1860

tttaaaaaac caacagagct ttttaaaaac attatttaaa atgagatttt tgggggcagg     1920

gggtggcaag acttgaattt tttttaaaca atgaagtaaa aaggtttcaa aatctctagt     1980

gttggctagt tctcaacatt ggctaaagta acatttcata aacactttac aagtattggt     2040

ccatatttaa gaatatctaa tgcttaaata atagattaat aacaattctt tcagtgcatt     2100

taaaatgtat ttttaaatat ctgaagtgag atggtgtgtt gaggtgaaaa tatcactgga     2160

ctaggaggaa ggtgacttag attctagtta cgtgtctttt acaacttcag ttttgggcaa     2220

atcactcact atccatttct tcatgttaag tcatctcaaa ggctatatct agcatcaact     2280

atgtgattta cattcagttt acataaggat atacctattt gtcaatctca gcacaatctg     2340

taacttttta cctatgttct cttcagcgcc agtcttaggc aaagttgtgc aagaggtgag     2400

gtttattttt gagaatctga tctccggtag caggtactcc tctcccatgt tagtgtcatc     2460

ttgcctgcct accttctaca tgccccatga cttgatgctt tctaattccc cgaacctcaa     2520

gatgtagtgc tgctttggat atctccatga ggtaataagt cacattagtc aggctcaaca     2580

taatctgaca gatactgtag tgggatttga tctaatagct aattttcagg tggtaactgt     2640

atcaatttaa ttttgatctt ttgaacatca tctctgctac ctggtccatt agtgactaag     2700

taggaaaagt aggaattttc atatctgtga tgtgtagaca gaccctatcc agtagaagaa     2760

tttaataaat ttaattaata aatactgaaa gatttcctta gataatccaa aactaggact     2820

agccctggta acggtgatac attccattat tttaataagt aaaatcttct tacaatgaaa     2880

aatactttaa aatttaattc ataaagctta ctttttagca gaattcattt attcaacaaa     2940

tacttgagtg cctgctagat gccaggttct acacaaggca ccggggatat tatggtattc     3000

ccaacaaggg acataatccc tatccttaag tagtactgtt attttagagt ggtctgtagt     3060

atattagtga ggcatttggc acatgaccca gagataatat aatgcatatt ttagttttgc     3120

acagaaggga tatggtctct aaggtttttt ccagctctaa aataattgtt cgctctgatt     3180

ccaataaact gtttaatcaa gctactttat ataaatcact ttacttcatt attttaaaga     3240

agtaaacttg actatattgt tttttatttg ggataattat gtgattctgt tgggatactt     3300

atatagtaca cattaaattg tatgtcagat gataacatta aaattcccaa gtgtaatatt     3360

ctacttggtc tctgtgtatc ataattaaaa tagatttaaa tattgagttc aaaaatagtt     3420

ttatttatct gggtgtgaat aaacagatgc ctgaactaat tcacagaaaa ggaaacttct     3480

gtgtaaaaag tcagtccaat ttctgaaatg ctatgctaaa ctacaggttt atggaacatt     3540

agatagggtg ttaagacttt atatagtact tcctcttgtt tctatacaag agaaagaaat     3600

ggccatactt caggaattgc agtgcataac tgagggattt ttaggactct tgaatttttg     3660

atgtagccgg gcaacttttt ttaggcagtg gtaattatcc tttattatgt gaattttgaa     3720

tggtttgaca aaacgtttgt ttttgtagag attttaaaag gggagcgcta atcctagaaa     3780

taaatattat gtaattatta cggccttaaa gataaaaatc cttgttgaaa gttgaaaaaa     3840

attgctaaat tacatagtct tagacattaa catgtttgtg gaagaatgta gcagaggtat     3900

gtagtataat ttgagtgaat attcccaatt aggaattcta ggctctagtt taactgagtc     3960

acactgcata ggaatttaga acctaacttc taggttatca aaatctttgc caccattgca     4020

caattttgtc ctaatatata gagaaacttt gtgaggcatg ttcagttgcg gtttgcacaa     4080

gttcatctca tttgtattcc agtgattttt tttcttctaa ccattttttt aaacaacatg     4140

tacacattgt tttttttggt aggcaatgaa aactgtcatt tccattgtca aacagtaatt     4200

cctcgataac tgtattaatg gtttttaaaa aaccatcagt tactttaaaa ctgaatttat     4260

atttaataac ttctgtatta gtattgggta gcatgaaatc tctattgaga aattgaacag     4320

catacaacta gtagctgtaa attccttcag aaagtgaaaa ttatttcttc ctaaagatat     4380

cttgacatca gtgcttgaag aatagtcata actagattaa taattgtttt agttaaacag     4440

ttttaagtgc ctgtttcaga tgatgatagg caatttagat gaatttagga aaaatcaaag     4500

tttttacttg cagaaatgtc cattataggg ggcccccctc ctcatagagc tgaatgggtt     4560

atgtaatgtt ttatccaaaa gtttccaatt ccactgtctt gtgttttcat gttgaaaata     4620

cttttgcatt tttcctttga gtgccaattt cttactagta ctatttctta atgtaacatg     4680

tttacctgga atgtatttta actatttttg tatagtgtaa actgaaacat gcacattttg     4740

tacattgtgc ttttttttgt gggacatatg cagtgtgatc cagttgtttt ccatcatttg     4800

gttgcgctga cctaggaatg ttggtcatat caaacattaa atttaaaaat gaccactctt     4860

ttaattaaaa ttaactttta aatgtttata ggagtatgtg ctgtgaagtg atctgaaatt     4920

tgtaatattt ttgtcatgaa ctgtactgct cctaattatt gtaatgtaat aaaaatagtt     4980

atggtgacta tga                                                        4993


<210>  33
<211>  4876
<212>  DNA
<213>  Canis lupus familiaris

<400>  33
gctgaaaatg actgaatata aacttgtggt agttggagct ggtggcgtag gcaagagtgc       60

cttgacgata cagctaattc agaatcactt tgtggatgaa tatgatccta caatagagga      120

ttcctacagg aaacaagtag taattgatgg agaaacctgt ctcttggata ttctcgacac      180

agcaggtcaa gaggagtaca gtgcaatgag ggaccagtac atgaggactg gggagggctt      240

tctttgtgta tttgccataa ataatactaa atcatttgaa gatattcacc attatagaga      300

acaaattaaa agagttaaag actctgaaga tgtacctatg gtcctagtag gaaataaatg      360

tgatttgcct tctagaacag tagacacaaa acaggctcag gacttagcaa gaagttatgg      420

aattcctttt attgaaacat cagcaaagac aagacagggt gttgacgatg ccttctatac      480

attagttcga gaaattcgaa aacataaaga aaagatgagc aaagatggta aaaagaagaa      540

aaagaagtca aagacaaagt gtataattat gtaaatacaa tttgtacttt tttcttaagg      600

catacttaag taaaagtggt aatttttgta cattacacta aattattagc atttgtttta      660

gcattaccta attttctgct ccatccaaac tgttagcttt tatcttgaat gcttatttta      720

aaatgacagt ggaaactttt tcctctaagt gccagtattc cctgagtttt ggttttgaac      780

tagcaatgcc tgtgaaaaag aaactgaata cctgagattt ctgtcttggg gtttttggtg      840

catgcagttg attacttcct atttttctta ccaattgtga actttggtgt gaaacaaatt      900

aatgaagctt tcgaatcatc cctattctgt gttttaccta gtcacataca tggattaatt      960

actaattata acttcagttg atatttcatg attggtttta ctgaaacatt gagggaacat     1020

gaatttatgg gctgcttctt ataggtataa tgtcctatag tttcagtcac ccttaatgaa     1080

tgtaaagcta cactgttcac aaaggttttc tccatctttt cactgctatt tgtcatagcc     1140

acgctcccaa aaatattata ttttttctat aaaaaaggga aaaaatagaa aaaaatacaa     1200

ggcaatggaa aatattaaaa ggcatttact ttccatatta gataaattcc tataatactc     1260

tgaatagctt ttcctgttaa ggcagaccca gtatgtaatg aggattatag caaccatttt     1320

ggggctatat ttacatgcta ctaaattttt gtattaattg aaaaagtttt aacatgtata     1380

aaaaattccc ataggaatta aatatagtct ccctgtgtca gattgctctt tcttagcata     1440

actttaaatc ttttcttgat cttcaatctt agaaaatagt tttaattctt gtagtgatgt     1500

taaagattat ttgggccagt tagtttttaa tagatgttaa agagaccaca gttccaaggc     1560

caggccttgt gtgaaccttt aagcttcatt aagagtttca tagtacagac tgcatccctg     1620

tggtctccca gggtcatcat gcattgattg ggtggtcaaa agtggggaca aagagtgttt     1680

agataagatg catcctcact gtatggtggt cctgctgaca gatcaggacc atcacttttg     1740

ttttttaaaa aaccaacaga gctttttaaa aacattattt aaaatgagat ttttgggggc     1800

agggggtggc aagacttgaa ttttttttaa acaatgaagt aaaaaggttt caaaatctct     1860

agtgttggct agttctcaac attggctaaa gtaacatttc ataaacactt tacaagtatt     1920

ggtccatatt taagaatatc taatgcttaa ataatagatt aataacaatt ctttcagtgc     1980

atttaaaatg tatttttaaa tatctgaagt gagatggtgt gttgaggtga aaatatcact     2040

ggactaggag gaaggtgact tagattctag ttacgtgtct tttacaactt cagttttggg     2100

caaatcactc actatccatt tcttcatgtt aagtcatctc aaaggctata tctagcatca     2160

actatgtgat ttacattcag tttacataag gatataccta tttgtcaatc tcagcacaat     2220

ctgtaacttt ttacctatgt tctcttcagc gccagtctta ggcaaagttg tgcaagaggt     2280

gaggtttatt tttgagaatc tgatctccgg tagcaggtac tcctctccca tgttagtgtc     2340

atcttgcctg cctaccttct acatgcccca tgacttgatg ctttctaatt ccccgaacct     2400

caagatgtag tgctgctttg gatatctcca tgaggtaata agtcacatta gtcaggctca     2460

acataatctg acagatactg tagtgggatt tgatctaata gctaattttc aggtggtaac     2520

tgtatcaatt taattttgat cttttgaaca tcatctctgc tacctggtcc attagtgact     2580

aagtaggaaa agtaggaatt ttcatatctg tgatgtgtag acagacccta tccagtagaa     2640

gaatttaata aatttaatta ataaatactg aaagatttcc ttagataatc caaaactagg     2700

actagccctg gtaacggtga tacattccat tattttaata agtaaaatct tcttacaatg     2760

aaaaatactt taaaatttaa ttcataaagc ttacttttta gcagaattca tttattcaac     2820

aaatacttga gtgcctgcta gatgccaggt tctacacaag gcaccgggga tattatggta     2880

ttcccaacaa gggacataat ccctatcctt aagtagtact gttattttag agtggtctgt     2940

agtatattag tgaggcattt ggcacatgac ccagagataa tataatgcat attttagttt     3000

tgcacagaag ggatatggtc tctaaggttt tttccagctc taaaataatt gttcgctctg     3060

attccaataa actgtttaat caagctactt tatataaatc actttacttc attattttaa     3120

agaagtaaac ttgactatat tgttttttat ttgggataat tatgtgattc tgttgggata     3180

cttatatagt acacattaaa ttgtatgtca gatgataaca ttaaaattcc caagtgtaat     3240

attctacttg gtctctgtgt atcataatta aaatagattt aaatattgag ttcaaaaata     3300

gttttattta tctgggtgtg aataaacaga tgcctgaact aattcacaga aaaggaaact     3360

tctgtgtaaa aagtcagtcc aatttctgaa atgctatgct aaactacagg tttatggaac     3420

attagatagg gtgttaagac tttatatagt acttcctctt gtttctatac aagagaaaga     3480

aatggccata cttcaggaat tgcagtgcat aactgaggga tttttaggac tcttgaattt     3540

ttgatgtagc cgggcaactt tttttaggca gtggtaatta tcctttatta tgtgaatttt     3600

gaatggtttg acaaaacgtt tgtttttgta gagattttaa aaggggagcg ctaatcctag     3660

aaataaatat tatgtaatta ttacggcctt aaagataaaa atccttgttg aaagttgaaa     3720

aaaattgcta aattacatag tcttagacat taacatgttt gtggaagaat gtagcagagg     3780

tatgtagtat aatttgagtg aatattccca attaggaatt ctaggctcta gtttaactga     3840

gtcacactgc ataggaattt agaacctaac ttctaggtta tcaaaatctt tgccaccatt     3900

gcacaatttt gtcctaatat atagagaaac tttgtgaggc atgttcagtt gcggtttgca     3960

caagttcatc tcatttgtat tccagtgatt ttttttcttc taaccatttt tttaaacaac     4020

atgtacacat tgtttttttt ggtaggcaat gaaaactgtc atttccattg tcaaacagta     4080

attcctcgat aactgtatta atggttttta aaaaaccatc agttacttta aaactgaatt     4140

tatatttaat aacttctgta ttagtattgg gtagcatgaa atctctattg agaaattgaa     4200

cagcatacaa ctagtagctg taaattcctt cagaaagtga aaattatttc ttcctaaaga     4260

tatcttgaca tcagtgcttg aagaatagtc ataactagat taataattgt tttagttaaa     4320

cagttttaag tgcctgtttc agatgatgat aggcaattta gatgaattta ggaaaaatca     4380

aagtttttac ttgcagaaat gtccattata gggggccccc ctcctcatag agctgaatgg     4440

gttatgtaat gttttatcca aaagtttcca attccactgt cttgtgtttt catgttgaaa     4500

atacttttgc atttttcctt tgagtgccaa tttcttacta gtactatttc ttaatgtaac     4560

atgtttacct ggaatgtatt ttaactattt ttgtatagtg taaactgaaa catgcacatt     4620

ttgtacattg tgcttttttt tgtgggacat atgcagtgtg atccagttgt tttccatcat     4680

ttggttgcgc tgacctagga atgttggtca tatcaaacat taaatttaaa aatgaccact     4740

cttttaatta aaattaactt ttaaatgttt ataggagtat gtgctgtgaa gtgatctgaa     4800

atttgtaata tttttgtcat gaactgtact gctcctaatt attgtaatgt aataaaaata     4860

gttatggtga ctatga                                                     4876


<210>  34
<211>  227
<212>  PRT
<213>  Canis lupus familiaris

<400>  34

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Asn Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Val Met Gly Val Asp 
            180                 185                 190         


Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile Arg Lys His Lys Glu Lys 
        195                 200                 205             


Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys Ser Lys Thr Lys Cys 
    210                 215                 220                 


Ile Ile Met 
225         


<210>  35
<211>  188
<212>  PRT
<213>  Canis lupus familiaris

<400>  35

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Ile Ile Met 
            180                 185             


<210>  36
<211>  1112
<212>  DNA
<213>  Gallus gallus

<400>  36
caggtctgct aaaaaatgac agagtataag cttgttgtcg ttggagctgg tggtgtgggc       60

aagagcgcct tgacaataca gctcattcag aaccactttg tggatgagta tgaccctacc      120

atagaggatt cctacagaaa gcaagtagta attgatgggg aaacctgtct cttggatatt      180

cttgatacag caggtcaaga agaatatagt gcaatgaggg accaatatat gagaacagga      240

gaaggctttc tgtgtgtttt tgctataaac aatacaaaat cttttgaaga tattcaccat      300

tatagggaac aaataaagag agttaaagac tctgaagatg tcccaatggt gctagtagga      360

aacaaatgtg atttgccttc cagaacagta gatacaaaac aagctcagga tttagcaaga      420

agttatggaa ttccttttat tgaaacatca gcaaagacaa gacagggtgt tgatgatgcc      480

ttctatacat tagttcgaga aatcagaaaa cacaaagaga agatgagcaa agatggtaaa      540

aagaagaaaa agaagacaaa gacaaagtgt ataattatgt aaatacaatg tatccttatt      600

cttaagacgt actgaagtaa tttttgtaca ttacactaaa ttattagcat ttgtttttag      660

cattacttta ctttctgctt catgatcctg ttagctttac ctgaatgctt gttttaaatg      720

acagtggaaa cttcattcct cttaaagtgc cagtattctt tgagtgttgg ttcttgaact      780

agcaatgcct gtgaagaaaa ataaaaacaa atgaaaaaaa aaaaaacaca caaaaacctg      840

agaactgtct taggactctt tggtgcatgc acagttgcta acttcctatt tttcttactg      900

attgtgaact tctgttccgt gcgtaaacaa aacaatgaaa cgatctacac gttctaacat      960

cccccttcat ttgtactctc ttatttttta catctggttg ggaaaacgga ccagttagtg     1020

acaaagactt tattttcaga cttccttcta atttcgactg actgcaatat agagagacca     1080

gaagccttta tagtcttcct gtagattttg ct                                   1112


<210>  37
<211>  188
<212>  PRT
<213>  Gallus gallus

<400>  37

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Thr Lys Thr Lys Cys Ile Ile Met 
            180                 185             


<210>  38
<211>  2144
<212>  DNA
<213>  Bos taurus

<400>  38
ggcggtggcg gcggcggcgg cggtggcggt ggcggttcgg ccagtactcc cggcccccgc       60

catttctgac tgggagcgag cgcggcgcag gcactgaagg cagcggcggg ggccagaggc      120

tcggcggctc ccaggtgagg gagagaggcc tgctgaaaat gactgaatat aaacttgtgg      180

tagttggagc tggtggcgta ggcaagagtg ccttgacgat acagctaatt cagaatcact      240

ttgtggatga atatgatcct acgatagagg attcctacag gaaacaagta gtaattgatg      300

gagaaacctg tctcttggat attctcgaca cagcaggtca agaggagtac agtgcaatga      360

gggaccagta catgaggact ggggagggct ttctttgtgt atttgccata aataatacta      420

aatcatttga agatattcac cattatagag aacaaataaa aagagttaaa gactctgaag      480

atgtacctat ggttctagta ggaaataaat gtgatttgcc ttctagaaca gtagacacaa      540

aacaggctca ggacttagca agaagttatg gaattccttt tattgaaaca tcagcaaaga      600

caagacaggg tgttgacgat gccttctata cattagttcg agaaattcga aaacataaag      660

aaaagatgag caaagatggt aaaaagaaga aaaagaagtc aaagacaaag tgtataatta      720

tgtaaataca atttgtactt ttttcttaag gcatacttaa gtaaaagtgg taatttttgt      780

atattacact aaattattag catttgtttt agcattatct aattttcttt ctgctccatc      840

catactgtta gcttttatct tgaatgctta ttttaaaatg acagtggaaa cttttttcct      900

ctaagtgcca gtattccctg cgttttggtt tttgaactag caatgcctgt gaaaaagaaa      960

ctgaacaccc aagatttttg tcttggggtt tttggtgcat gcagttgatt acttcctatt     1020

tttcttatca attgtgaact ttagtgtgaa acaaattaat gaggctttca aatcatccct     1080

attgtattgt tttatctagt cacacacatg gattaattac taattataac ttcagttgag     1140

atttcatgat tggttttact gaaacatcga gggaacatga atttatgggc ttcctatagt     1200

ttcatcttgt aggtatcatt gtcctatagt ttcagttacc cttaatgaat gtcaggttac     1260

actgttcaca aaggttttct tctttccact gctatttgtc aaatggtcac gttccctaaa     1320

atactatatt ttttctataa aaaaaagaaa aaaatggaaa aaaatacaag gcaatggaaa     1380

atattaaaag gccacttact ttccacatta ggtaaattcc tataatgctc tgaatagctt     1440

tttatgttaa ggcagaccca gtaggtaatg aggattagaa caagcatttt gggactatat     1500

ttacatgctt taaatttttg taataacaaa aaaattttaa catgtataaa gaattctcat     1560

aggaattaaa tacagtctcc ctgtgtcaga ttgctctttc ttagcataaa tctttttctt     1620

gaacttcaat ctttaaaagt agttttaatt ctactgatag tgatgtaaaa gattatttgg     1680

gccagttagc ttggtaggtg ttacagagac cagggtggca tagccgggcc ttgtgtgaac     1740

ctttaagcta catggagagt ttcacagtgt ggactgcatc cctgtggtct tccattgttg     1800

ccatgccttg gttggtcaaa aacaaggact tgcagagaga ttgaatagct cagcaaggta     1860

cattctcatt atgtcgtagt cctactcagg aacatcactt ttttaaaata aaaaacccca     1920

aaaaacagaa cttaaaaaaa aaaacaacat tattttaaat gagattttcg gtggggtgga     1980

aagattttaa ttttttttaa acgatgaaat gaaaaaatgt caaaatcttg agtattggct     2040

agttctcttt aacactggct aaagtaacat ttttgtaaac acttcagtac agtctggtcc     2100

attattaaga atatctaatg cttatacaat aaagtaatgc taac                      2144


<210>  39
<211>  188
<212>  PRT
<213>  Bos taurus

<400>  39

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Ile Ile Met 
            180                 185             


<210>  40
<211>  4454
<212>  DNA
<213>  Homo sapiens

<400>  40
gaaacgtccc gtgtgggagg ggcgggtctg ggtgcggcct gccgcatgac tcgtggttcg       60

gaggcccacg tggccggggc ggggactcag gcgcctgggg cgccgactga ttacgtagcg      120

ggcggggccg gaagtgccgc tccttggtgg gggctgttca tggcggttcc ggggtctcca      180

acatttttcc cggctgtggt cctaaatctg tccaaagcag aggcagtgga gcttgaggtt      240

cttgctggtg tgaaatgact gagtacaaac tggtggtggt tggagcaggt ggtgttggga      300

aaagcgcact gacaatccag ctaatccaga accactttgt agatgaatat gatcccacca      360

tagaggattc ttacagaaaa caagtggtta tagatggtga aacctgtttg ttggacatac      420

tggatacagc tggacaagaa gagtacagtg ccatgagaga ccaatacatg aggacaggcg      480

aaggcttcct ctgtgtattt gccatcaata atagcaagtc atttgcggat attaacctct      540

acagggagca gattaagcga gtaaaagact cggatgatgt acctatggtg ctagtgggaa      600

acaagtgtga tttgccaaca aggacagttg atacaaaaca agcccacgaa ctggccaaga      660

gttacgggat tccattcatt gaaacctcag ccaagaccag acagggtgtt gaagatgctt      720

tttacacact ggtaagagaa atacgccagt accgaatgaa aaaactcaac agcagtgatg      780

atgggactca gggttgtatg ggattgccat gtgtggtgat gtaacaagat acttttaaag      840

ttttgtcaga aaagagccac tttcaagctg cactgacacc ctggtcctga cttccctgga      900

ggagaagtat tcctgttgct gtcttcagtc tcacagagaa gctcctgcta cttccccagc      960

tctcagtagt ttagtacaat aatctctatt tgagaagttc tcagaataac tacctcctca     1020

cttggctgtc tgaccagaga atgcacctct tgttactccc tgttattttt ctgccctggg     1080

ttcttccaca gcacaaacac acctctgcca ccccaggttt ttcatctgaa aagcagttca     1140

tgtctgaaac agagaaccaa accgcaaacg tgaaattcta ttgaaaacag tgtcttgagc     1200

tctaaagtag caactgctgg tgattttttt tttcttttta ctgttgaact tagaactatg     1260

ctaatttttg gagaaatgtc ataaattact gttttgccaa gaatatagtt attattgctg     1320

tttggtttgt ttataatgtt atcggctcta ttctctaaac tggcatctgc tctagattca     1380

taaatacaaa aatgaatact gaattttgag tctatcctag tcttcacaac tttgacgtaa     1440

ttaaatccaa ctttcacagt gaagtgcctt tttcctagaa gtggtttgta gacttccttt     1500

ataatatttc agtggaatag atgtctcaaa aatccttatg catgaaatga atgtctgaga     1560

tacgtctgtg acttatctac cattgaagga aagctatatc tatttgagag cagatgccat     1620

tttgtacatg tatgaaattg gttttccaga ggcctgtttt ggggctttcc caggagaaag     1680

atgaaactga aagcacatga ataatttcac ttaataattt ttacctaatc tccacttttt     1740

tcataggtta ctacctatac aatgtatgta atttgtttcc cctagcttac tgataaacct     1800

aatattcaat gaacttccat ttgtattcaa atttgtgtca taccagaaag ctctacattt     1860

gcagatgttc aaatattgta aaactttggt gcattgttat ttaatagctg tgatcagtga     1920

ttttcaaacc tcaaatatag tatattaaca aattacattt tcactgtata tcatggtatc     1980

ttaatgatgt atataattgc cttcaatccc cttctcaccc caccctctac agcttccccc     2040

acagcaatag gggcttgatt atttcagttg agtaaagcat ggtgctaatg gaccagggtc     2100

acagtttcaa aacttgaaca atccagttag catcacagag aaagaaattc ttctgcattt     2160

gctcattgca ccagtaactc cagctagtaa ttttgctagg tagctgcagt tagccctgca     2220

aggaaagaag aggtcagtta gcacaaaccc tttaccatga ctggaaaact cagtatcacg     2280

tatttaaaca tttttttttc ttttagccat gtagaaactc taaattaagc caatattctc     2340

atttgagaat gaggatgtct cagctgagaa acgttttaaa ttctctttat tcataatgtt     2400

ctttgaaggg tttaaaacaa gatgttgata aatctaagct gatgagtttg ctcaaaacag     2460

gaagttgaaa ttgttgagac aggaatggaa aatataatta attgatacct atgaggattt     2520

ggaggcttgg cattttaatt tgcagataat accctggtaa ttctcatgaa aaatagactt     2580

ggataacttt tgataaaaga ctaattccaa aatggccact ttgttcctgt ctttaatatc     2640

taaatactta ctgaggtcct ccatcttcta tattatgaat tttcatttat taagcaaatg     2700

tcatattacc ttgaaattca gaagagaaga aacatatact gtgtccagag tataatgaac     2760

ctgcagagtt gtgcttctta ctgctaattc tgggagcttt cacagtactg tcatcatttg     2820

taaatggaaa ttctgctttt ctgtttctgc tccttctgga gcagtgctac tctgtaattt     2880

tcctgaggct tatcacctca gtcatttctt ttttaaatgt ctgtgactgg cagtgattct     2940

ttttcttaaa aatctattaa atttgatgtc aaattaggga gaaagatagt tactcatctt     3000

gggctcttgt gccaatagcc cttgtatgta tgtacttaga gttttccaag tatgttctaa     3060

gcacagaagt ttctaaatgg ggccaaaatt cagacttgag tatgttcttt gaatacctta     3120

agaagttaca attagccggg catggtggcc cgtgcctgta gtcccagcta cttgagaggc     3180

tgaggcagga gaatcacttc aacccaggag gtggaggtta cagtgagcag agatcgtgcc     3240

actgcactcc agcctgggtg acaagagaga cttgtctcca aaaaaaaagt tacacctagg     3300

tgtgaatttt ggcacaaagg agtgacaaac ttatagttaa aagctgaata acttcagtgt     3360

ggtataaaac gtggttttta ggctatgttt gtgattgctg aaaagaattc tagtttacct     3420

caaaatcctt ctctttcccc aaattaagtg cctggccagc tgtcataaat tacatattcc     3480

ttttggtttt tttaaaggtt acatgttcaa gagtgaaaat aagatgttct gtctgaaggc     3540

taccatgccg gatctgtaaa tgaacctgtt aaatgctgta tttgctccaa cggcttacta     3600

tagaatgtta cttaatacaa tatcatactt attacaattt ttactatagg agtgtaatag     3660

gtaaaattaa tctctatttt agtgggccca tgtttagtct ttcaccatcc tttaaactgc     3720

tgtgaatttt tttgtcatga cttgaaagca aggatagaga aacactttag agatatgtgg     3780

ggttttttta ccattccaga gcttgtgagc ataatcatat ttgctttata tttatagtca     3840

tgaactccta agttggcagc tacaaccaag aaccaaaaaa tggtgcgttc tgcttcttgt     3900

aattcatctc tgctaataaa ttataagaag caaggaaaat tagggaaaat attttatttg     3960

gatggtttct ataaacaagg gactataatt cttgtacatt atttttcatc tttgctgttt     4020

ctttgagcag tctaatgtgc cacacaatta tctaaggtat ttgttttcta taagaattgt     4080

tttaaaagta ttcttgttac cagagtagtt gtattatatt tcaaaacgta agatgatttt     4140

taaaagcctg agtactgacc taagatggaa ttgtatgaac tctgctctgg agggagggga     4200

ggatgtccgt ggaagttgta agacttttat ttttttgtgc catcaaatat aggtaaaaat     4260

aattgtgcaa ttctgctgtt taaacaggaa ctattggcct ccttggccct aaatggaagg     4320

gccgatattt taagttgatt attttattgt aaattaatcc aacctagttc tttttaattt     4380

ggttgaatgt tttttcttgt taaatgatgt ttaaaaaata aaaactggaa gttcttggct     4440

tagtcataat tctt                                                       4454


<210>  41
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  42
<211>  4470
<212>  DNA
<213>  Mus musculus

<400>  42
gggactgggg cgccttgggc gcctagtgat tacgtagcgg gtggggccgg aagtgccgct       60

ccctggcggg ggctgttcat ggcggtttcg gggtctccaa cagcttctca ggttgaagtc      120

caaaagcctc ccgaggcggg gtctgcggag tttgaggttt ttgctggtgt gaaatgactg      180

agtacaaact ggtggtggtt ggagcaggtg gtgttgggaa aagcgccttg acgatccagc      240

taatccagaa ccactttgtg gatgaatatg atcccaccat agaggattct taccgaaagc      300

aagtggtgat tgatggtgag acctgcctgc tggacatact ggacacagct ggacaagagg      360

agtacagtgc catgagagac cagtacatga ggacaggcga agggttcctc tgtgtatttg      420

ccatcaataa tagcaaatca tttgcagata ttaacctcta cagggagcaa attaagcgtg      480

tgaaagattc tgatgatgtc cccatggtgc tggtaggcaa caagtgtgac ttgccaacaa      540

ggacagttga cacaaagcaa gcccacgaac tggccaagag ttacggaatt ccattcattg      600

agacctcagc caagacccga cagggtgtgg aggatgcctt ttacacactg gtaagggaga      660

tacgccagta ccgaatgaaa aagctcaaca gcagtgacga tggcactcaa ggttgtatgg      720

ggctgccctg tgtgctgatg tagtaagaca ctttgaaagt tctgtcatca gaaaagagcc      780

actttgaagc tgcactgatg ccctggttct gacatccctg gaggagacct gttcctgctg      840

ctctctgcat ctcagagaag ctcctgcttc ctgcttcccc gactcagtta ctgagcacag      900

ccatctaacc tgagacctct tcagaataac tacctcctca ctcggctgtc tgaccagaga      960

aatagacctg tctctcccgg tcgttctctg ccctgggttc ccctagaaac agacacagcc     1020

tccagctggc tttgtcctct gaaaagcagt ttacattgat gcagagaacc aaactagaca     1080

tgccattctg ttgacaacag tttcttatac tctaaggtaa caactgctgg tgattttccc     1140

ctgcccccaa ctgttgaact tggccttgtt ggtttggggg gaaaatgtca taaattactt     1200

tcttcccaaa atataattag tgttgctgat tgatttgtaa tgtgatcagc tatattccat     1260

aaactggcat ctgctctgta ttcataaatg caaacacgaa tactctcaac tgcatgcaat     1320

taaatccaac attcacaaca aagtgccttt ttcctaaaag tgctctgtag gctccattac     1380

agtttgtaat tggaatagat gtgtcaagaa ccattgtata ggaaagtgac tctgagccat     1440

ctacctttga gggaaaggtg tatgtacctg atggcagatg ctttgtgtat gcacatgaag     1500

atagtttccc tgtctgggat tctcccagga gaaagatgga actgaaacaa ttacaagtaa     1560

tttcatttaa ttctagctaa tctttttttt tttttttttt ttttttggta gactatcacc     1620

tataaatatt tggaatatct tctagcttac tgataatcta ataattaatg agcttccatt     1680

ataatgaatt ggttcatacc aggaagccct ccatttatag tatagatact gtaaaaattg     1740

gcatgttgtt actttatagc tgtgattaat gattcctcag accttgctga gatatagtta     1800

ttagcagaca ggttatatct ttgctgcata gtttcttcat ggaatatata tctatctgta     1860

tgtggagaga acgtggccct cagttccctt ctcagcatcc ctcatctctc agcctagaga     1920

agttcgagca tcctagaggg gcttgaacag ttatctcggt taaaccatgg tgctaatgga     1980

ccgggtcatg gtttcaaaac ttgaacaagc cagttagcat cacagagaaa cagtccatcc     2040

atatttgctc cctgcctatt attcctgctt acagactttt gcctgatgcc tgctgttagt     2100

gctacaagga taaagcttgt gtggttctca ccaggactgg aagtacctgg tgagctctgg     2160

ggtaagccta gatatcttta cattttcaga cccttattct tagccacgtg gaaactgaag     2220

ccagagtcca tacctccatc tccttccccc cccaaaaaaa ttagattaat gttctttata     2280

tagctttttt aaagtattta aaacatgtct ataagttagg ctgccaacta acaaaagctg     2340

atgtgtttgt tcaaataaag aggtatcctt cgctactcga gagaagaatg taaaatgcca     2400

ttgattgttg tcacttggag gcttgatgtt tgccctgata attcattagt gggttttgtt     2460

tgtcacatga tacctaagat gtaactcagc tcagtaattc taatgaaaac ataaattgga     2520

taccttaatt gaaaaaagca aacctaattc caaaatggcc attttctctt ctgatcttgt     2580

aatacctaaa attctgaggt ccttgggatt cttttgttta taacaggatc ttgctgtgta     2640

gtcctagctg gcctcaaact cacaatactc ttcctggatc aatctcccaa gtgctgggat     2700

tacaggcaca ttccaccaca cacacctgac tgagctcgtt cctaatgagt tttcattaag     2760

caaattcccc atcaccttga aactaatcag aagggggaag aaacatttgc tatgctcctg     2820

agtgctaaca ctgggatcat tcacatgggg tttgcattcc taggcaaact aaactgctgc     2880

cttttacaac aaggctcagt catcttcctg aagctgctga gaccagcact tggtcttgtt     2940

ttgttttaat atgtctatat gactggtggt ggatccctaa atagtttatt aattaaactc     3000

cagttaagga gaaagttact caccttgacc cgtttgacca tatcccgtgt gtgtgtgtgt     3060

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgcacgcgt atgtacgtac gtatgtatgt     3120

aggtatgtag gtggtttcca gtataaacac agaaacaaat ggagccaatt caggtttcag     3180

atgcccttac taacatatat tcccacgggg tgtgggtttt ggcacaacag tgacaaactt     3240

aaaagccaag taagagccgg gcgtggtggc gcacgccttt aatcccagca cttgggaggc     3300

agaggcaggc ggatttctga gttctaggcc atcctggtct acagtgagtt ccaggacagc     3360

cagtgctaca cagagaaacc ctgtctcgaa aagccaaaaa aaaaaaaaaa aaaaaaaaaa     3420

aaaagccaag taggtccagt tggtatagta tcaaagtgtt tttagagtaa ttagtgaagg     3480

tctgctttac ctcaaagttg cagagcctct cttcctgagt ttaagtgcct ggccggcagt     3540

cacaaattaa catgttgctg taaggcagtt agttgaagct ttgttcacac attggagagt     3600

atgaaaataa agtgttctaa gagcgctgat actggatctg tgtaaacctg gtaaatgccg     3660

tttgtccagg acttagcgtg tgtgagttgg tagctcagta cgagtttact agttccgcag     3720

tgtgtacaat ggaggcgggt ttgttttagc tggccacctg tagaatcagc ctttaaactg     3780

ctgtgaactt tgtcatgact tgaatatgaa gatagacaaa aactctgtaa agacaaatgt     3840

ttgttttccc ccttacagaa cgtgtgagct tggttttatc ttcctttgta tttagtcata     3900

acctctcaag ctggcagctc cgaccaagga tcagaagctg tgtgcgttcc acctggtgga     3960

attagctcag ctctatatga gaagtggagt taatggaaaa cgtgttgact gggtggtttc     4020

tatttaaaag agtgatgata attcttgaac agtagttttt attttgctat ttctttaagc     4080

tgactgatgt gccacaaaat tattttaagg tatttgtgtt ttaagagtgt tctcatgaga     4140

ttagttgtag atatttttta aaatacaact ggtttttaaa atctgagtat tgctctaagc     4200

aagtgtttag actcttacgg gaaggtgggt ggaagttgtt tggcttccgt atttccatgc     4260

gtgccgtcag acataggtca gaacgccaac tgtgcatcct gctgtttaaa gacctcttgg     4320

cctctgtgac cctcatgaag gggctgatat tttaagttga ctgtttgatt gtaaattaat     4380

cctttctaat ttttaaagac ttgcttgact gttttccttg ttaaataatt ttaaaaaaat     4440

aaaaaactgg aagttctttg cttaactgta                                      4470


<210>  43
<211>  189
<212>  PRT
<213>  Mus musculus

<400>  43

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Leu Met 
            180                 185                 


<210>  44
<211>  1326
<212>  DNA
<213>  Rattus norvegicus

<400>  44
gccgttcatg gcggtttcgg ggtctccaac agcttctcag gttgaaatcc aaaagcctcc       60

cgaggcgggg tctgcggagt ttgagatttt tgcaggtgtg aaatgactga gtacaaactg      120

gtggtggttg gagcaggtgg cgttgggaaa agtgctttga caatccagct aatccagaac      180

cactttgtgg atgaatatga tcccaccata gaggattctt accgaaaaca agtggtgatt      240

gacggtgaga cctgtctact ggacatactg gacacagctg gacaagagga gtacagtgcc      300

atgagagacc aatacatgag gacaggcgaa gggttcctct gtgtgtttgc catcaataat      360

agcaaatcct ttgcagatat taacctctac agggagcaaa ttaagcgcgt gaaagactct      420

gatgatgtac ccatggtgct ggtagggaac aagtgtgact tgccaacaag gacagttgac      480

acaaagcaag cccacgagct ggccaagagt tatggaattc cattcattga aacctcagcc      540

aagacccgac agggtgtgga ggatgccttt tacacgcttg taagggagat acgccagtac      600

cggatgaaga agctcaacag cagtgaggat ggcactcaag gctgtatggg gctgccctgt      660

gtggtgatgt agtaagaccc tttaaaagtt ctgtcatcag aaacgagcca ctttcaagcc      720

tcactgatgc cctggttctg acatccctgg aggagacgtg tttctgctgc tctctgcatc      780

tcagagaagc tcctgcttcc tgcttcccca acttagttac tgagcacagc catctaacct      840

gagacctctt cagaataact acctcctcac tcggctgtcc gaccagagaa atgaacctgt      900

ttctccccag tagttctctg ccctgggttt cccctagaaa caaacacacc tgccagctgg      960

ctttgtcctc cgaaaagcag tttacattga tgcagagaac caaactatag acaagcaatt     1020

ctgttgtcaa cagtttctta agctctaagg taacaattgc tggtgatttc cccctttgcc     1080

cccaactgtt gaacttggcc ttgttagttt tgggggaaat gtcaaaaatt aatctcttcc     1140

cgagaataga attagtgttg ctgattgcct gatttgcaat gtgatcagct atattctata     1200

agctggcgtc tgctctgtat tcataaatgc aaacatgagt actgacgtaa gtgcatccct     1260

agtcttctca gctgcatgca attaaatcca acgttcacaa caaaaaaaaa aaaaaaaaaa     1320

aaaaaa                                                                1326


<210>  45
<211>  189
<212>  PRT
<213>  Rattus norvegicus

<400>  45

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Glu Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  46
<211>  1253
<212>  DNA
<213>  Canis lupus familiaris

<400>  46
ggcggttccg gggtctccaa cctttctcct agttgtggtc ctaaatacgt cggaagcgga       60

ggcggcgaag cttgaggttc ttgctggtgt gaaatgactg agtacaaact ggtggtggtt      120

ggagcaggtg gtgttgggaa aagcgcactg acaatccagc taatccagaa ccactttgta      180

gatgaatatg atcccaccat agaggattct taccgaaaac aggtggttat agacggtgaa      240

acctgtctgt tggatatact ggatacagct ggtcaagaag agtacagtgc catgagagac      300

caatacatga ggacaggcga aggcttcctc tgtgtatttg ccatcaataa tagcaaatca      360

tttgcagaca ttaacctcta cagggaacag attaagcgag taaaagattc agatgatgta      420

cctatggtgc tagtaggaaa caagtgtgat ttgccaacaa ggacagttga cacaaaacaa      480

gcccatgaac tggccaagag ttatgggatt ccattcattg aaacctcagc caagaccaga      540

cagggtgtcg aggatgcctt ttacacactg gtaagagaaa tacgtcagta ccgaatgaag      600

aaactcaaca gcagtgatga tgggactcaa ggttgtatgg ggttaccatg tgtggtgatg      660

taacaagaca cttttaaagt tctagcatca gaaaagagcc actgtcaagc tgcactgaca      720

ccctggtcct gacttccctg gaggagaagt attcctgttg ctatcttcag tctcacaaag      780

aagctcctgc tacttcccca actctcagta gatcagtaca atgttctcta tttgagaagt      840

tctccgaaca actacctcct cacttggttg tctgaccaga gaaatgaacc tcttgttcct      900

tcccgctgtt tttccaccct gaattctccc ccaacacaca taaacaaacc tctgccatcc      960

caggtttttc atctgaaaaa taattcatgc tctgaaacag agaacaaaac tgtagacatg     1020

aaattctgta ggaaacaagg tcttgagctc aaaagtagca actgctggtg accttttttt     1080

cccccctttt tactgttgaa cttggaacta tgttggtttt tggagaaatg tcataagtta     1140

ctgttttgct gagaatatag ttaagttgac atttggtttg tttgtaatat cattagctat     1200

tttctataaa ttggcatctg ctctgcattc ataaatacac gagtgaattc tga            1253


<210>  47
<211>  189
<212>  PRT
<213>  Canis lupus familiaris

<400>  47

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  48
<211>  4825
<212>  DNA
<213>  Gallus gallus

<400>  48
gcgccgggac cggaagccgg aagctttgca gaagggtgtt ccgcgttcgc ggtgcgggag       60

cggtcagccg gggtggcggg gctggggccg gccggggcag gcggctccgc gctccgcact      120

gggccgctgg gagggcgatg actgaataca agctggtggt ggtgggagct ggcggcgtcg      180

ggaagagcgc gttgaccatc cagctcatcc agaaccactt cgtggacgag tacgacccca      240

ccatcgagga ttcgtacaga aagcaggttg tcatcgatgg agagacgtgc ttgttggaca      300

ttctggacac tgcaggacag gaagaataca gtgctatgcg tgatcagtac atgagaactg      360

gggaaggatt cctttgtgtg tttgccatta acaacagtaa atcattcgct gatattaacc      420

tttacagaga gcaaatcaag agagtgaaag attcagacga tgtgccaatg gtgctggtgg      480

ggaataagtg cgatttgcca acaaggacag tagacaccaa acaggctcaa gagttagcaa      540

aaagctacgg cattcccttc atagagacat cagccaaaac gagacagggt gtggaagatg      600

cgttttacac actggtgagg gagattcggc agtaccggat gaaaaagctc aacagcaacg      660

aagatgggaa tcagggctgt atggggttgt cctgcattgt gatgtgataa gatgccaggt      720

tcagatgtag ctgctggaca agtctcgatg ctactgtatt gtgtctcatg ctgatgccct      780

gcagtatttt ggtgccagcg accagactct tggtaccagt taattagctc aggatccttt      840

cctgtgctcc atctgaagaa aacatctctg gtatctacct ccttgctcag ctcacagagc      900

agtcatatct cttggtgtac tgggattctt ttctagctgt gttgtctggg tttgttcaag      960

aagaaaacca gtcacaagaa aagtgaatta cagagactaa atgctgtgaa aaagatcaca     1020

ctttacctcc agagtaaaag ctagaagtgg cgtttgaccc ctttgcattg gattcagatt     1080

tgcggtgttg tcagaggagt ggcagaagta attttgccat tacaaaggtt tctgtcacca     1140

gtcggattgg tatctgctgt ctgtgcaccc acacagtgta tctgcaacat ctgcattgtg     1200

ccagaagtat cacttaactg atgaactgat cctttatttt tctgtaataa aaaggagata     1260

tctttgctaa cttaagtgcc tgtttgctca gaaggttgga ggttgtatgc tgttcccttg     1320

ggctgaggag aaccccaagg atgaatttct tgggtgctca ttgtcttgag caggcaagtt     1380

ttgtgtgggt gatctctttt catggcagga tattaaaatg ggaatttgta gtctggaaga     1440

tggagcagct gtttgtgaga ctcttgagtt agggagagaa atgtatacca cgtctgttct     1500

cgatccatca gaatggatcc atccacctct ttgtgtgtgg aactgtgtat agtctgtatt     1560

ggttttctac agcacttgga tctctttgga ccaaattagc gagctgttca ttttaacata     1620

actgccagta tttatagaca atttcttacg gacagataat gaatttagaa actggaggtt     1680

actttgggca gctgttcctc agctctgtct gtaacttgca aattattctg agttattttc     1740

tgcagaacct ccttccttat cacgggagga gcctgggagt tgaggttgac tgtaattggg     1800

tcaatggttg tcacagactt aaggtgtcca ggctgattgg aggaggcact gagccctaac     1860

agagcactga gctgacttct aattgcagca tccttgcaaa atgaggaagg gagttcagtg     1920

atgtctgcac tgaagatgta tgatacactg atagcagttc tgggtatgtt gtaacagctt     1980

caaagtagaa ccgcagtact gcgtgagctg tgtgacttct tcctagaaca cagcactgtc     2040

accccatatg gttgggacgt gcaggtgaga ccaacaccta ccaggttccc tggcgtaccg     2100

tggccttctc agttcttgtg ccagtgatac tgggttctgt tctgtggtgt cagacagcgt     2160

cctgtagcaa agctgaattc ccacttagtc tggtgagaga ataaagagcc atcagccaac     2220

agagggagcg ttcattctgc tggagcagtg cgagctgtaa gcattacgag aggcgtagtt     2280

tcagtttgtt gcagtcaggt tcctatattt tcaaagctga aatcagaaat aagtaaatac     2340

ggagaaaata agctgttgct tttaatgctc tttcctccac taattgtact cttaattttc     2400

ttcttgggag gccgaggatc catctgcata actttagctg tgatgctcca gataagtgtt     2460

tagaattcat tttatctttg actgatggga ctgataagaa gttaacgcac aatattttta     2520

catacaacat cgttttccag tgacctcctg agcggtggga agcattatgg gatagcaccg     2580

gctgtgactc gagttcattt gaaggcgatc tcttgcctgc aggttaaatg ggacggagtc     2640

agaatcactg tgagccgtct gtaatcagca aacagtctgt gggcttttct tactgtgttc     2700

tctctgtttg ccttagtttg gtgcaggaag agttccttgt gacagcgtcc tttgaggtgt     2760

gttgcaggag ctgaccattt gctccttgag ctgtgtgatg aactgttgtc cacttaatgg     2820

agttacagaa gcagcttctg ggagtcgcat ctggtcgcat acattcagtg ttttgggaag     2880

ctgtcagtgt ggtgtttgca ctgtgtttga atggtgttca tggtgggtct gttatgctcc     2940

tggatgattt ggggagatgt ggggctgctt ccgtggcaga caggatcagc tcagggcgct     3000

gctgcctatg gctgtgggaa acctcacagt tggtgtttga atagtggcca agtatgtcaa     3060

ttaaaaatac attttgaagg gaggtttgtc atagctctgt actttggcat gctctgctta     3120

ctgaaaacat actagctgta gctcaaaaaa agttgtgaat cctcagaata atacaggagc     3180

tggcaattgt ggctgctttc tctttgtgtt ccttttctct tgggttggat gaagctttaa     3240

aaaggaagga gccctggtga gggttggtca gtgtgcattt cattcttgga accagagagg     3300

aagttgcatc aactttcagg acgctgcaga gctcacttgc acaggtggtg ctccagtcta     3360

tgtgattttt ggggtcaaat cttgagatga tcttacaaaa tcagattttg tacccatcat     3420

gagcatgagg tgagtggttg tgctcggttt ctagctgcat gtatgtatac agacacgtgt     3480

atgcagacat gtctatgtgt gagtagttcg agtcagtcaa ggttactggc agcacctaaa     3540

gcgtatgcac cacataatgc atgcaggcaa aagtcctatc ttaggagcca tctcttcatg     3600

ggtttgggtt tatataggca gtatttttaa acagaatatc cgaagcactt tctggagttc     3660

tgtggtaatg cagtgacacc tatttggatg aaggaagatg tgtctgagga gcacgtaagc     3720

agatttgctg ccctaacaga gaggttttgg taaccgtgga aaaggttttc tcctggatct     3780

gtgtgtgctc ttggtgagct gcaatccatg acagggcaca accagatgag aaggaaaccc     3840

ggccatccca tgcttgagca cagctctgac tcagtagttc caccagatgt gccctttcag     3900

tcaaagtgtt ctgatctctt agagctttct gtagttcaag ttaccactca ctctccagct     3960

tgctcggtta atgtctgttg gcggcgttga gttggacttg ggaaaggtgt gtgtggtagg     4020

aacaagcaga gtgtgatgtg cttctgttat caggacttaa gctagagtgg ttggcagata     4080

ggaaatgcag ctattccttg aaagcaagca gatcatggat ggtcagccaa actgccctgg     4140

ctttggtggg agctgcactg cagaaggacc aaaccccaac aagatttggc acatttgttt     4200

agaagataag cacagatggt tttgcacaag gcagctcctc ataatggtgg ctttgtagat     4260

ttagtccaaa tgttcttatt tagatctagc agcacatcac tgtgtccgtg cccatctaac     4320

ctcgctatcc taagtagagc agaccccaaa caaccttgtt caaaaactac cagtgcaaat     4380

aactgaacta aatatttgtt actgctgact gagaacagct gttcgagtgt agcattgtgg     4440

cttgttaatg tgagtgcccc aactctatgg tcttattaaa gaaacccaaa cattgctcag     4500

attttgttct tattgtcatc ataagacttg aatagtgatg gtaatgctta cgtagacgtg     4560

tcttgtgagt gcacttcagt gatttagaaa gaactggatt tcaagcaact ttggacctgt     4620

ggggggaggg agattaatga aggtttgaat cacattctaa ttctatgtac agtccttcat     4680

tactccacaa gcctaaatcc tatacagcct ccaggatagc tggaaactgt tgagatctgg     4740

actttttttt tttaatccaa gggctaactt gttgtaactt ggtataatta tctgctttcg     4800

gaaatgcatc tctgttggtt tgaaa                                           4825


<210>  49
<211>  189
<212>  PRT
<213>  Gallus gallus

<400>  49

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Asn Glu Asp 
                165                 170                 175     


Gly Asn Gln Gly Cys Met Gly Leu Ser Cys Ile Val Met 
            180                 185                 


<210>  50
<211>  4283
<212>  DNA
<213>  Bos taurus

<400>  50
ggccgctccc tagtgggggc tgttcatggc ggttccgggg tctcccaaca attttcccgg       60

ttgtggtcgt aatctatccg aagtggaggc agtggagcta gaggttcttg ctggtgtgaa      120

atgactgagt acaaactggt ggtggttgga gcaggtggtg ttgggaaaag tgcactgaca      180

atccagctaa tccagaacca ctttgtagat gaatatgatc ccaccataga ggattcctac      240

cgaaaacagg tggttataga tggtgaaacc tgtctgttgg acatactgga tacagctgga      300

caagaggagt acagtgccat gagagaccaa tacatgagga caggcgaagg cttcctttgt      360

gtgtttgcca tcaataatag caaatcattt gcagatatta acctctacag ggaacagata      420

aagcgtgtaa aggactcgga tgatgtacct atggtgctag taggaaacaa gtgtgatttg      480

ccaacaagga cagttgacac aaaacaagcc catgaactgg ccaaaagtta tgggattcca      540

ttcattgaaa cctcagccaa gaccagacag ggtgttgaag atgcctttta cacactggta      600

agagaaatac gtcagtaccg aatgaaaaag ctcaacagca gtgatgatgg cactcaaggc      660

tgtatggggt tgccgtgtgt ggtgatgtaa caagatactt ttaaagttct cacatcagaa      720

aagagccact gtcaagctgc actgacaccc tggtcctgac ttccctggag gagaagtatt      780

cctgttgcta tcttcagttt caaaaagaag ctcctgctat ttccccaact ctcagtagat      840

caatataata ttctctattt gagaagttct caagaataac tacctcctca cttggttgtc      900

tgaccagaga attgaacctc ttgttactcc cagtattttt ccaccctggg ttctccccca      960

gcacacacaa acgcacctct gccacccagg tttttcatct gaaaagcaat taatactctg     1020

aaacagagaa ccaaactgta gaaacatgaa attctgtaga aaacaatgtc ttgagctcta     1080

aagtagcaac tgctggtgat tttttttttt tttttttcct ttttattgtt gaacttggaa     1140

ctatgttggt ttgtggagaa atgtcataaa ttactgtttt gctgagaata tagttaatgt     1200

tgctctctgg tttgtttgta atgttatcag ctatattcta taaactggca tctactctgt     1260

atttagaaat acaaaaatga atactgacct tttgagtcta ccctcatctt ctcgactttc     1320

ttgtaattaa atgtaacttt cacgatgaag tgccttttgc ctgggagtga ctcgtagact     1380

tcctttaaaa tacttcagtg gaatagatgt ctcagaaact gttatacata agaataaatg     1440

tctgagatat gtctatgacc catctagctt tgagggaaag atataccaat atgatagcag     1500

atgccatttc ttacatctat aacgttgatt ttctggagac ctattttggg gctctccgag     1560

agaaagatga gactataaat gattaggaat aatttcactt aatttttaca taacctccac     1620

tttttgtttt gtagtttact acctgcaaaa catataattt gattcctttt agcttacaga     1680

taatctaatg ttaaatgaac ttccattcat attttaattt ggatcatatc aggaagtcta     1740

catttgcagg tgttcaaaaa ttgtaaaagt gtgatgcagt tttatttaat agctgtgatc     1800

aatgattttc aagcctcaaa tatgttaata gacacatttt cactgtatat catggtatta     1860

ataattattg atgtatataa ttgtccttgg tccccttctc tgttcatcac ctcatggcaa     1920

tggcttgatt aattatttca gctgagtaaa gcatggtgct aatagaccag ggtcacagtg     1980

tcaaaacttc agtgagccag taagcatcac agagaaagaa attctttcac atttgctcac     2040

cattaactcc agctaatagt tttgccagat gtgtgtggtt agtcctgcaa ggaaaggaga     2100

agtcagttaa tacaaattct taaccaggac tggaaaaact tgttttcctg agaagggtca     2160

gcttagaagt ctttatctgg actctatttt tagccacatg gaaatcaaat taagctgatc     2220

ttttttctca agtttttgag agtgaggatg cctcagatca acatttttaa aatattcttt     2280

attcttacgt tcttttaagg gtttaaaaca acgttgagta attagtctgg gcataccagg     2340

taacaagctg ataagtttgt gctgaacaag aagtagcctt tggattgaaa ttgctgtttt     2400

gagaagggat agaaaatata attaataatt atgagacttg acttttctat ttgcagataa     2460

tatcctgata attctgatga aaatagactt ggataatttt tgataaaaga atcgttccaa     2520

aatggccact tgctgttctt gtcttctaat gtgtaaatac ttactgaggt cctcttctaa     2580

tatgagttgt catttattaa gcaaattcca cattgccttg aaatgaattc ggaagagaag     2640

aaaaagtcat agtataccca gagaatgaaa aatccagaga attgtgctcc ttagtgttaa     2700

ttctgaagcc ttcgtagtcc acacccatag acagaaactc tctgccactt tgcttctgct     2760

cctcttggag cattgcgctg tcatttcctt gaggatagat tgaggcttgt caactcagtt     2820

gtattgtctt cctcctcttc ctcttgtctg tgtgactgac agtgtgactc ttactaatgt     2880

cagatgcggg gatgcgggga ggtggggggg agtagctcat tttaggctct tgcacccttt     2940

accgttgtat gtgtgtgtct tttagttttc tcaagaatgt tctaagcaca gaagtatcta     3000

aatggggcca aaattcagac ttgaaaatgt tcttttaata gcttcttaaa aagttacact     3060

ttggtgtgaa ttttggcagg atagagtgac aaactcttaa acgctgaata acttcagtta     3120

gtgtgttata gtttttagaa tatgtttgtg attgctgaaa acaattatag tttacctcaa     3180

aatctgaaag tctctttccc caagttaagt gcctggccag ctgtcaaaga ttacatatta     3240

ctttatgttt gtttgttttt taaaggttgc acattcaaga ttgtgaaaat aaggtgttct     3300

gtctgaaagc taccatgcct gtctgtaaat gaatccactg agtgctgtac ttgttccaac     3360

agcttactac agaatgctac ttggtaatat catactcgtt acagttttca cttcaggagt     3420

gtactaggta gaatgatcct gtgtgtattg tagtgggctc catgtttagt cttttcagca     3480

tcctttaaac tgctgtgaat ttttgtcttg acttgaaagc aaggatagag aaacacttta     3540

aagagatact ttgggttttt ttccattcca gaattggtga gcatagttag attttgcttt     3600

acatttacag tcatgaactc ttaagctggc agctacaacc aagaaccaaa agagggtgca     3660

ttctgcttct tgtaattcat ctttgctaat aaattatgag aagcaaagat aattaattag     3720

agaaactatt ttatttgggt ggtttctata aacaagggac tataattctt aaacattatt     3780

tttcattttt gctgtttctt taagaaacct aatgtgccac aacattattt taaggtgttt     3840

cttaaaagaa ttgtttttaa aagtgttctc attttcagag taattgtaga tatatttcaa     3900

aatataactg ataattttta aaggcctgag tactgaccta agaagcagtt gtatgaattc     3960

tctgggggga agggaggagc tcagtgaaag ttgtatgact tttatatttc tgtgccatca     4020

aataaaggta aaaatgtctt ttgtgcagtt ttgctgttca aacagaaact attggcctcc     4080

ttggccctaa atgaaagggc tggtatttta agttgactat tttattgtaa attaatccat     4140

cttaattttt ttaaatttgg ttgaatgttc tcttgttaaa tgtttaaaaa ataaaaactg     4200

gaagttcttt gcttagtcat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4260

aaaaaaataa aaaaaaaaaa aaa                                             4283


<210>  51
<211>  189
<212>  PRT
<213>  Bos taurus

<400>  51

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  52
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  52
gctggtgtga aatgact                                                      17


<210>  53
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  53
gctaccactg ggcctcacct                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  54
ggatgtgccc tgaaggacaa                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  55
tgcggatcca gggtaagaag                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  56
gagtggcagg gggaagatgc                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  57
cctcagggca ctgcaggatg                                                   20


<210>  58
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  58
gcccgacgtg cattcccgat tcctt                                             25


<210>  59
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  59
gacggctttc tccctcttgc tgacg                                             25


<210>  60
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  60
tcaagaggtg ccacgtctcc                                                   20


<210>  61
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  61
tcttggcagc aggatagtcc tt                                                22


<210>  62
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  62
atatgatcca acaatagagg cttcctacag gaagcaagta g                           41


<210>  63
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  63
ctacttgctt cctgtaggaa gcctctattg ttggatcata t                           41


<210>  64
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  64
cattttgtgg acgaatatga tccaacaaat gaggattcct acagg                       45


<210>  65
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  65
cctgtaggaa tcctcatttg ttggatcata ttcgtccaca aaatg                       45


<210>  66
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  66
atatgatcca acaatagagg cttcctacag gaagcaagta g                           41


<210>  67
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  67
ctacttgctt cctgtaggaa gcctctattg ttggatcata t                           41


<210>  68
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  68
cattttgtgg acgaatatga tccaacaaat gaggattcct acagg                       45


<210>  69
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  69
cctgtaggaa tcctcatttg ttggatcata ttcgtccaca aaatg                       45




