                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  GLP-1/GLUCAGON RECEPTOR CO-AGONISTS FOR MEDICAL USE

<130>  130034WO01

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  2
<211>  30
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  His or Imp

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib or Acb

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Gln or His

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Tyr, Leu, Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Ser, Ala, Leu, Thr, Glu, Aib, Ile, Val or Lys

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Arg, Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Arg, Ala or Lys

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Gln, Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Asp, Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Gln, Ala, Arg, Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Asn, Ser, Thr, Gln, Ala, Gly, Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Thr, Gly, Ser, Gln, Ala, Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  this residue is absent or represents Lys

<400>  2

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Trp Leu Ile Xaa Xaa Xaa 
            20                  25                  30  


<210>  3
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  3

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Lys Trp Leu Ile Ser Thr 
            20                  25                  


<210>  4
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  4

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Lys Arg Ala Arg Glu Phe Val Lys Trp Leu Ile Ser Thr 
            20                  25                  


<210>  5
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  5

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  6
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  6

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Val Lys Trp Leu Ile Ser Thr 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  7

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  8
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  8

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  9
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  9

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  10

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  11
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  11

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  12
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  misc
<222>  (2)..(2)
<223>  Aib

<220>
<221>  misc
<222>  (29)..(29)
<223>  C-terminal amide

<400>  12

His Xaa Gln Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  13
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  13

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Lys Trp Leu Ile Ser Thr 
            20                  25                  


<210>  14
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  14

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Leu 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Lys Trp Leu Ile Ser Thr 
            20                  25                  


<210>  15
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  15

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  16
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  16

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Arg Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  17
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  17

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  18

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  19
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  19

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Arg Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  20
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  20

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  21

His Xaa Gln Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  22
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  22

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Gln Trp Leu Ile Asn Lys 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  23

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Val Gln Trp Leu Ile Asn Lys 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  24

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Leu 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Val Gln Trp Leu Ile Asn Lys 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  25

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Gln Trp Leu Ile Asn Lys 
            20                  25                  


<210>  26
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  26

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Ala Trp Leu Ile Asn Lys 
            20                  25                  


<210>  27
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  27

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  28
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  28

His Xaa Gln Gly Thr Phe Thr Ser Asp Ile Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  29
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  29

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Gln Trp Leu Ile Ser Lys 
            20                  25                  


<210>  30
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  misc
<222>  (2)..(2)
<223>  Aib

<220>
<221>  misc
<222>  (29)..(29)
<223>  C-terminal amide

<400>  30

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Val Gln Trp Leu Ile Ser Lys 
            20                  25                  


<210>  31
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  31

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Gln Trp Leu Ile Ser Lys 
            20                  25                  


<210>  32
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  32

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Val Gln Trp Leu Ile Ser Lys 
            20                  25                  


<210>  33
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  33

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Ala Trp Leu Ile Ser Lys 
            20                  25                  


<210>  34
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  34

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Ala Trp Leu Ile Lys Thr 
            20                  25                  


<210>  35
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  35

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Leu 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Ala Trp Leu Ile Lys Thr 
            20                  25                  


<210>  36
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  36

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Ala Trp Leu Ile Lys Thr 
            20                  25                  


<210>  37
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  37

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Ala Trp Leu Ile Ser Lys 
            20                  25                  


<210>  38
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  38

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  39
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  39

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Arg Asp Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  40
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Acb

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  40

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  41
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  41

His Xaa Gln Gly Thr Phe Thr Ser Asp Val Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  42
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human glucagon


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  42

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Tyr Leu Asp Val 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Ile Lys Thr 
            20                  25                  


<210>  43
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Acylation at epsilon amino group

<400>  43

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  44
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  DesaminoHis

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Acylation at epsilon amino group

<400>  44

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  45
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Acylation at epsilon amino group

<400>  45

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  46
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human GLP-1


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Acylation at epsilon amino group

<400>  46

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Xaa Arg Lys 
            20                  25                  30      


<210>  47
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial amino acid sequence based on human insulin


<220>
<221>  DISULFID
<222>  (7)..(7)
<223>  Disulfide bond between this residue and the residue in position 
       12 of SEQ ID NO 47

<220>
<221>  DISULFID
<222>  (8)..(8)
<223>  Disulfide bond between this residue and the residue in position 7
       of SEQ ID NO 48

<220>
<221>  DISULFID
<222>  (12)..(12)
<223>  Disulfide bond between this residue and the residue in position 7
       of SEQ ID NO 47

<220>
<221>  DISULFID
<222>  (21)..(21)
<223>  Disulfide bond between this residue and the residue in position 
       19 of SEQ ID NO 48

<400>  47

Gly Ile Val Glu Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
1               5                   10                  15      


Leu Glu Asn Tyr Cys Asn 
            20          


<210>  48
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Artificial amino acid sequence based on human insulin


<220>
<221>  DISULFID
<222>  (7)..(7)
<223>  Disulfide bond between this residue and the residue in position 7
       of SEQ ID NO 47

<220>
<221>  DISULFID
<222>  (19)..(19)
<223>  Disulfide bond between this residue and the residue in position 
       21 of SEQ ID NO 47

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Acylation at epsilon amino group

<400>  48

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  


