                         SEQUENCE LISTING

<110>  The Secretary of State for Health
 
<120>  Early diagnosis of Leptospire

<130>  P41130WO

<150>  GB 1410118.2
<151>  2014-06-06

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  1508
<212>  DNA
<213>  Leptospira interrogans

<400>  1
acacggagag tttgatcctg gctcagaact aacgctggcg gcgcgtctta aacatgcaag       60

tcaagcggag tagcaatact cagcggcgaa cgggtgagta acacgtgggt aatcttcctc      120

tgagtctggg ataactttcc gaaagggaag ctaatactgg atggtcccga gagatcataa      180

gatttttcgg gtaaagattt attgctcgga gatgagcccg cgtccgatta gctagttggt      240

gaggtaaagg ctcaccaagg cgacgatcgg tagccggcct gagagggtgt tcggccacaa      300

tggaactgag acacggtcca tactcctacg ggaggcagca gttaagaatc ttgctcaatg      360

gggggaaccc tgaagcagcg acgccgcgtg aacgatgaag gtcttcggat tgtaaagttc      420

agtaagcagg gaaaaataag cagcaatgtg atgatggtac ctgcctaaag caccggctaa      480

ctacgtgcca gcagccgcgg taatacgtat ggtgcaagcg ttgttcggaa tcattgggcg      540

taaagggtgc gtaggcggac atgtaagtca ggtgtgaaaa ctgcgggctc aactcgcagc      600

ctgcacttga aactatgtgt ctggagtttg ggagaggcaa gtggaattcc aggtgtagcg      660

gtgaaatgcg tagatatctg gaggaacacc agtggcgaag gcgacttgct ggcctaaaac      720

tgacgctgag gcacgaaagc gtgggtagtg aacgggatta gataccccgg taatccacgc      780

cctaaacgtt gtctaccagt tgttgggggt tttaaccctc agtaacgaac ctaacggatt      840

aagtagaccg cctggggact atgctcgcaa gagtgaaact caaaggaatt gacgggggtc      900

cgcacaagcg gtggagcatg tggtttaatt cgatgatacg cgaaaaacct cacctaggct      960

tgacatggag tggaatcatg tagagataca tgagccttcg ggccgcttca caggtgctgc     1020

atggttgtcg tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg agcgcaaccc     1080

tcaccttatg ttgccatcat tcagttgggc actcgtaagg aactgccggt gacaaaccgg     1140

aggaaggcgg ggatgacgtc aaatcctcat ggcctttatg tctagggcaa cacacgtgct     1200

acaatggccg gtacaaaggg tagccaactc gcgaggggga gctaatctca aaaatccggt     1260

cccagttcgg attggagtct gcaactcgac tccatgaagt cggaatcgct agtaatcgcg     1320

gatcagcatg ccgcggtgaa tacgttcccg gaccttgtac acaccgcccg tcacaccacc     1380

tgagtgggga gcacccgaag tggtctttgc caaccgcaag gaagcagact actaaggtga     1440

aactcgtgaa gggggtgaag tcgtaacaag gtagccgtat cggaaggtgc ggctggatca     1500

cctccttt                                                              1508


<210>  2
<211>  10
<212>  DNA
<213>  Leptospira interrogans

<400>  2
ggtgttcggc                                                              10


<210>  3
<211>  10
<212>  DNA
<213>  Leptospira interrogans

<400>  3
gccgaacacc                                                              10


<210>  4
<211>  10
<212>  DNA
<213>  Leptospira interrogans

<400>  4
ggtgtccggc                                                              10


<210>  5
<211>  10
<212>  DNA
<213>  Leptospira interrogans

<400>  5
gccggacacc                                                              10


<210>  6
<211>  10
<212>  DNA
<213>  Leptospira interrogans

<400>  6
ggtgaacggc                                                              10


<210>  7
<211>  10
<212>  DNA
<213>  Leptospira interrogans

<400>  7
gccgttcacc                                                              10


<210>  8
<211>  10
<212>  DNA
<213>  Leptospira interrogans

<400>  8
ccacaagccg                                                              10


<210>  9
<211>  10
<212>  DNA
<213>  Leptospira interrogans

<400>  9
ccacaggccg                                                              10


<210>  10
<211>  10
<212>  DNA
<213>  Leptospira interrogans

<400>  10
ccacttgccg                                                              10


<210>  11
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  11
gccgaacacc                                                              10


<210>  12
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  12
ggtgttcggc                                                              10


<210>  13
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  13
gccggacacc                                                              10


<210>  14
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  14
ggtgtccggc                                                              10


<210>  15
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  15
gccgttcacc                                                              10


<210>  16
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  16
ggtgaacggc                                                              10


<210>  17
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  17
ccacaagccg                                                              10


<210>  18
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  18
ccacttgccg                                                              10


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  19
agagggtgtt cggccacaat g                                                 21


<210>  20
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  20
gggtgttcgg ccaca                                                        15


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  21
tctcccacaa gccggtgttc                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  22
tctcccacaa gccggtgtta                                                   20


<210>  23
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  23
cccacaagcc ggtg                                                         14


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  24
tctcccacaa gccggtgtta c                                                 21


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  25
cttgtggccg aacaccctct                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  26
attgtggccg aacaccctct                                                   20


<210>  27
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  27
gtggccgaac accc                                                         14


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  28
cattgtggcc gaacaccctc t                                                 21


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  29
agagggtgtc cggccacaat                                                   20


<210>  30
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  30
gggtgtccgg ccac                                                         14


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  31
tctcccacag gccggtgtta                                                   20


<210>  32
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  32
cccacaggcc ggtg                                                         14


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  33
attgtggccg gacaccctct                                                   20


<210>  34
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  34
gtggccggac accc                                                         14


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  35
agagggtgaa cggccacaat g                                                 21


<210>  36
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  36
gggtgaacgg ccaca                                                        15


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  37
tctcccactt gccggtgtta c                                                 21


<210>  38
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  38
cccacttgcc ggtgt                                                        15


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  39
cattgtggcc gttcaccctc t                                                 21


<210>  40
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  40
tgtggccgtt caccc                                                        15


<210>  41
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  41
ccaggacaag                                                              10


<210>  42
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  42
ggtcctgttc                                                              10


<210>  43
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  43
cttgtcctgg                                                              10


<210>  44
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is FAM Label

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is BHQ Quencher

<400>  44
ntaaagccag gacaagcgcc gn                                                22


<210>  45
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  45
ggatctgtga tcaactatta cggata                                            26


<210>  46
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  46
cccatttgca gcgattac                                                     18


<210>  47
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  47
ccacacaatc tgc                                                          13


<210>  48
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  48
ctcccatttc agcgattac                                                    19


<210>  49
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  49
ggtgtgttag acg                                                          13


<210>  50
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  50
gcagattgtg tgg                                                          13


<210>  51
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  51
cccacaagcc ggtgt                                                        15


<210>  52
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  52
tgtggccgaa caccc                                                        15


<210>  53
<211>  450
<212>  DNA
<213>  Leptospira interrogans

<400>  53
gaaaaaactt tcgatthtgg chatctccgt tgcactcttt gcaagcatta ccgcttgtgg       60

tgcbttcggt ggtctgccaa gcctaaaaag ctcttttgtt ctgagcgagg asacaatccc      120

agggacaaac gaaaccgtaa aaacgttact tccctacgga tctgtgatca actattacgg      180

atacgtaaag ccaggacaag cgccggacgg tttagtcgat ggaaacaaaa aagcatacta      240

tctctatgtt tggattcctg ccgtaatcgc tgcaaatggg agttcgtatg atttccccaa      300

caggcgaaat cggtgarcca ggcgayggag acttagtaag cgacgctttc aaagcggcta      360

ccccagaaga aaaatcaatg ccacattggt ttgatacttg gatccgtgta gaaagaatgt      420

cggcgattat gcctgaccaa atcgycaaag                                       450


<210>  54
<211>  24
<212>  DNA
<213>  Leptospira santarosai

<400>  54
taggtgactt tccattttga tact                                              24


<210>  55
<211>  21
<212>  DNA
<213>  Leptospira weilii

<400>  55
gyttaggtac ttccatgyag c                                                 21


<210>  56
<211>  21
<212>  DNA
<213>  Leptospira borgpetersenii

<400>  56
kykywrrryr myyywykywr y                                                 21


<210>  57
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  57
cattagcgac gtttaccc                                                     18


<210>  58
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  58
ccacaggccg                                                              10


<210>  59
<211>  150
<212>  DNA
<213>  Leptospira interrogans

<400>  59
gctcaccaag gcgacgatcg gtagccggcc tgagagggtg ttcggccaca atggaactga       60

gacacggtcc atactcctac gggaggcagc agttaagaat ccttgctcaa tgggggggaa      120

ccctgaagca gcgacgccgc gtgaaagatg                                       150


<210>  60
<211>  11
<212>  DNA
<213>  Leptospira biflexa

<400>  60
yyaraassca g                                                            11


<210>  61
<211>  23
<212>  DNA
<213>  Borrelia

<400>  61
cttaaaaatc gccgcagcga tta                                               23


<210>  62
<211>  24
<212>  DNA
<213>  Treponema pallidum

<400>  62
aattaaaatg tcgcacgaat cggt                                              24


<210>  63
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  63
gatcggtarc cggcct                                                       16


<210>  64
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  64
cgatcagtar ccggcct                                                      17


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  65
cccattgagc aagattctta a                                                 21


<210>  66
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  66
cctgtccttt taccagacaa cca                                               23


<210>  67
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  67
ggtctctctt ttcgttggga tc                                                22


<210>  68
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is Cy5 Label

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  n is BHQ-2 Quencher

<400>  68
ntacctgtcc acacaatctg ccctttcgn                                         29


<210>  69
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is FAM Label

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is BHQ-1 Quencher

<400>  69
nagagggtgt tcggccacaa tgn                                               23


<210>  70
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is JOE Label

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is BHQ-1 Quencher

<400>  70
nagagggtgt ccggccacaa tn                                                22


<210>  71
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is Cy5 Label

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is BHQ-2 Quencher

<400>  71
nagagggtga acggccacaa tgn                                               23


