                         SEQUENCE LISTING

<110>  Vally Health System
       Wistar Institute
 
<120>  Method and Systems for Lung Cancer Diagnosis

<130>  104321.00012

<140>  PCT/US15/33658
<141>  2015-06-15

<150>  62/006,549
<151>  2014-06-02

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  2881
<212>  DNA
<213>  Homo sapiens

<400>  1
ccagctggca gtcaaggctg taggagggca tggagagttg aagaaaaaag cagtatcttg       60

aggcagactg gaagagtcat cacagcatcc aaatcaacaa gaaaacatca ttccagggtc      120

ctacatgatg gcgtactctg atactacaat gatgtctgat gatattgact ggttacgcag      180

ccacaggggt gtgtgcaagg tagatctcta caacccagaa ggacagcaag atcaggaccg      240

gaaagtgata tgctttgtcg atgtgtccac cctgaatgta gaagataaag attacaagga      300

tgctgctagt tccagctcag aaggcaactt aaacctggga agtctggaag aaaaagagat      360

tatcgtgatc aaggacactg agaagaaaga ccagtctaag acagagggat ctgtatgcct      420

tttcaaacaa gctccctctg atcctgtaag tgtcctcaac tggcttctca gtgatctcca      480

gaagtatgcc ttgggtttcc aacatgcact gagcccctca acctctacct gtaaacataa      540

agtaggagac acagagggcg aatatcacag agcatcctct gagaactgct acagtgtcta      600

tgccgatcaa gtgaacatag attatttgat gaacagacct caaaacctac gtctagaaat      660

gacagcagct aaaaacacca acaataatca aagtccttca gctcctccag ccaaacctcc      720

tagcactcag agagcagtca tttcccctga tggagaatgt tctatagatg acctttcctt      780

ctacgtcaac cgactatctt ctctggtaat ccagatggcc cataaggaaa tcaaggagaa      840

gttggaaggt aaaagcaaat gccttcatca ttcaatctgt ccatcccctg ggaacaaaga      900

gagaatcagt ccccgaactc ctgcgagcaa gattgcttct gaaatggcct atgaagctgt      960

ggaactgaca gctgcagaaa tgcgtggcac tggagaggag tccagggaag gtggccagaa     1020

aagctttcta tatagcgaat tatccaacaa gagcaaaagt ggagacaaac agatgtccca     1080

gagagagagc aaagaatttg cagattccat cagcaagggg ctcatggttt atgcaaatca     1140

ggtggcatct gacatgatgg tctctctcat gaagaccttg aaagtgcaca gctctgggaa     1200

gccaattcca gcatctgtgg tcctgaagag ggtgttgcta aggcacacca aggagattgt     1260

gtccgatttg attgattctt gcatgaagaa cctgcataat attactgggg tcctgatgac     1320

tgactcagac tttgtctcag ctgtcaagag aaatctgttc aaccagtgga aacaaaatgc     1380

tacagacatc atggaggcca tgctgaagcg cttggtcagt gcccttatag gtgaggagaa     1440

ggagactaag tctcagagtc tgtcatatgc atctttaaaa gctgggtccc atgatcccaa     1500

atgcaggaat cagagtcttg aattctccac catgaaagct gaaatgaaag agagggacaa     1560

aggcaaaatg aaatcagacc catgcaagtc actgactagt gctgagaaag tcggtgaaca     1620

cattctcaaa gagggcctaa ccatctggaa ccaaaagcaa ggaaactcat gcaaggtggc     1680

taccaaagca tgcagcaata aagatgagaa aggagaaaag atcaatgctt ccacagattc     1740

actggccaag gacctgattg tctctgccct taagctgatc cagtaccatc tgacccagca     1800

gactaagggc aaagatacat gtgaagaaga ctgtcctggt tccaccatgg gctatatggc     1860

tcagagtact caatatgaaa agtgtggagg tggccaaagt gccaaagcac tttcagtgaa     1920

acaactagaa tctcacagag cccctggacc atccacctgt caaaaggaga accaacacct     1980

ggactcccag aaaatggata tgtcaaacat cgttctaatg ctgattcaga aactgcttaa     2040

tgagaacccc ttcaaatgtg aggatccatg cgaaggtgag aacaagtgtt ctgagcccag     2100

ggcaagcaaa gcagcttcca tgtccaacag atctgacaaa gcggaagaac aatgccagga     2160

gcatcaagaa cttgactgta ccagtgggat gaagcaagcg aacgggcaat ttatagataa     2220

actagtagaa tctgtgatga agctctgcct tatcatggct aagtatagca acgatggggc     2280

agcccttgct gagttggaag aacaagcagc ctcggcaaat aagcccaatt tcaggggcac     2340

cagatgcatt cacagtggtg caatgccaca gaactatcaa gactctcttg gacatgaagt     2400

aattgtcaat aatcagtgct ctacaaatag cttgcagaag cagctccagg ctgtcctgca     2460

gtggattgca gcctcccagt ttaacgtgcc catgctctac ttcatgggag ataaggatgg     2520

acaactggaa aagcttcctc aggtttcagc taaagcagca gagaaggggt acagtgtagg     2580

aggtcttctt caagaggtca tgaagtttgc caaggaacgg caaccagatg aagctgtggg     2640

aaaggtggcc aggaaacagt tgctggactg gctgctcgct aacctgtgag ctgatccttg     2700

actcctcttc atcttagccc ccctagcagc attccatccc agccagagca cccccaccat     2760

caggccagtc aactgcacaa tacacaactg tatttcccaa tacacttgag cagttgcctg     2820

tgaatgtaag aggtgtcaac aaactgggaa ataaaataaa aaaaaataat aataaatgtg     2880

t                                                                     2881


<210>  2
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Met Ala Tyr Ser Asp Thr Thr Met Met Ser Asp Asp Ile Asp Trp 
1               5                   10                  15      


Leu Arg Ser His Arg Gly Val Cys Lys Val Asp Leu Tyr Asn Pro Glu 
            20                  25                  30          


Gly Gln Gln Asp Gln Asp Arg Lys Val Ile Cys Phe Val Asp Val Ser 
        35                  40                  45              


Thr Leu Asn Val Glu Asp Lys Asp Tyr Lys Asp Ala Ala Ser Ser Ser 
    50                  55                  60                  


Ser Glu Gly Asn Leu Asn Leu Gly Ser Leu Glu Glu Lys Glu Ile Ile 
65                  70                  75                  80  


Val Ile Lys Asp Thr Glu Lys Lys Asp Gln Ser Lys Thr Glu Gly Ser 
                85                  90                  95      


Val Cys Leu Phe Lys Gln Ala Pro Ser Asp Pro Val Ser Val Leu Asn 
            100                 105                 110         


Trp Leu Leu Ser Asp Leu Gln Lys Tyr Ala Leu Gly Phe Gln His Ala 
        115                 120                 125             


Leu Ser Pro Ser Thr Ser Thr Cys Lys His Lys Val Gly Asp Thr Glu 
    130                 135                 140                 


Gly Glu Tyr His Arg Ala Ser Ser Glu Asn Cys Tyr Ser Val Tyr Ala 
145                 150                 155                 160 


Asp Gln Val Asn Ile Asp Tyr Leu Met Asn Arg Pro Gln Asn Leu Arg 
                165                 170                 175     


Leu Glu Met Thr Ala Ala Lys Asn Thr Asn Asn Asn Gln Ser Pro Ser 
            180                 185                 190         


Ala Pro Pro Ala Lys Pro Pro Ser Thr Gln Arg Ala Val Ile Ser Pro 
        195                 200                 205             


Asp Gly Glu Cys Ser Ile Asp Asp Leu Ser Phe Tyr Val Asn Arg Leu 
    210                 215                 220                 


Ser Ser Leu Val Ile Gln Met Ala His Lys Glu Ile Lys Glu Lys Leu 
225                 230                 235                 240 


Glu Gly Lys Ser Lys Cys Leu His His Ser Ile Cys Pro Ser Pro Gly 
                245                 250                 255     


Asn Lys Glu Arg Ile Ser Pro Arg Thr Pro Ala Ser Lys Ile Ala Ser 
            260                 265                 270         


Glu Met Ala Tyr Glu Ala Val Glu Leu Thr Ala Ala Glu Met Arg Gly 
        275                 280                 285             


Thr Gly Glu Glu Ser Arg Glu Gly Gly Gln Lys Ser Phe Leu Tyr Ser 
    290                 295                 300                 


Glu Leu Ser Asn Lys Ser Lys Ser Gly Asp Lys Gln Met Ser Gln Arg 
305                 310                 315                 320 


Glu Ser Lys Glu Phe Ala Asp Ser Ile Ser Lys Gly Leu Met Val Tyr 
                325                 330                 335     


Ala Asn Gln Val Ala Ser Asp Met Met Val Ser Leu Met Lys Thr Leu 
            340                 345                 350         


Lys Val His Ser Ser Gly Lys Pro Ile Pro Ala Ser Val Val Leu Lys 
        355                 360                 365             


Arg Val Leu Leu Arg His Thr Lys Glu Ile Val Ser Asp Leu Ile Asp 
    370                 375                 380                 


Ser Cys Met Lys Asn Leu His Asn Ile Thr Gly Val Leu Met Thr Asp 
385                 390                 395                 400 


Ser Asp Phe Val Ser Ala Val Lys Arg Asn Leu Phe Asn Gln Trp Lys 
                405                 410                 415     


Gln Asn Ala Thr Asp Ile Met Glu Ala Met Leu Lys Arg Leu Val Ser 
            420                 425                 430         


Ala Leu Ile Gly Glu Glu Lys Glu Thr Lys Ser Gln Ser Leu Ser Tyr 
        435                 440                 445             


Ala Ser Leu Lys Ala Gly Ser His Asp Pro Lys Cys Arg Asn Gln Ser 
    450                 455                 460                 


Leu Glu Phe Ser Thr Met Lys Ala Glu Met Lys Glu Arg Asp Lys Gly 
465                 470                 475                 480 


Lys Met Lys Ser Asp Pro Cys Lys Ser Leu Thr Ser Ala Glu Lys Val 
                485                 490                 495     


Gly Glu His Ile Leu Lys Glu Gly Leu Thr Ile Trp Asn Gln Lys Gln 
            500                 505                 510         


Gly Asn Ser Cys Lys Val Ala Thr Lys Ala Cys Ser Asn Lys Asp Glu 
        515                 520                 525             


Lys Gly Glu Lys Ile Asn Ala Ser Thr Asp Ser Leu Ala Lys Asp Leu 
    530                 535                 540                 


Ile Val Ser Ala Leu Lys Leu Ile Gln Tyr His Leu Thr Gln Gln Thr 
545                 550                 555                 560 


Lys Gly Lys Asp Thr Cys Glu Glu Asp Cys Pro Gly Ser Thr Met Gly 
                565                 570                 575     


Tyr Met Ala Gln Ser Thr Gln Tyr Glu Lys Cys Gly Gly Gly Gln Ser 
            580                 585                 590         


Ala Lys Ala Leu Ser Val Lys Gln Leu Glu Ser His Arg Ala Pro Gly 
        595                 600                 605             


Pro Ser Thr Cys Gln Lys Glu Asn Gln His Leu Asp Ser Gln Lys Met 
    610                 615                 620                 


Asp Met Ser Asn Ile Val Leu Met Leu Ile Gln Lys Leu Leu Asn Glu 
625                 630                 635                 640 


Asn Pro Phe Lys Cys Glu Asp Pro Cys Glu Gly Glu Asn Lys Cys Ser 
                645                 650                 655     


Glu Pro Arg Ala Ser Lys Ala Ala Ser Met Ser Asn Arg Ser Asp Lys 
            660                 665                 670         


Ala Glu Glu Gln Cys Gln Glu His Gln Glu Leu Asp Cys Thr Ser Gly 
        675                 680                 685             


Met Lys Gln Ala Asn Gly Gln Phe Ile Asp Lys Leu Val Glu Ser Val 
    690                 695                 700                 


Met Lys Leu Cys Leu Ile Met Ala Lys Tyr Ser Asn Asp Gly Ala Ala 
705                 710                 715                 720 


Leu Ala Glu Leu Glu Glu Gln Ala Ala Ser Ala Asn Lys Pro Asn Phe 
                725                 730                 735     


Arg Gly Thr Arg Cys Ile His Ser Gly Ala Met Pro Gln Asn Tyr Gln 
            740                 745                 750         


Asp Ser Leu Gly His Glu Val Ile Val Asn Asn Gln Cys Ser Thr Asn 
        755                 760                 765             


Ser Leu Gln Lys Gln Leu Gln Ala Val Leu Gln Trp Ile Ala Ala Ser 
    770                 775                 780                 


Gln Phe Asn Val Pro Met Leu Tyr Phe Met Gly Asp Lys Asp Gly Gln 
785                 790                 795                 800 


Leu Glu Lys Leu Pro Gln Val Ser Ala Lys Ala Ala Glu Lys Gly Tyr 
                805                 810                 815     


Ser Val Gly Gly Leu Leu Gln Glu Val Met Lys Phe Ala Lys Glu Arg 
            820                 825                 830         


Gln Pro Asp Glu Ala Val Gly Lys Val Ala Arg Lys Gln Leu Leu Asp 
        835                 840                 845             


Trp Leu Leu Ala Asn Leu 
    850                 


<210>  3
<211>  2867
<212>  DNA
<213>  Homo sapiens

<400>  3
caggggtggc agccaactgc aggtgcccaa gaacttggca cttctcagtt ccatctaaag       60

gggcacatct cccttctggg tgtcacgttt tcagccaaac atctaaaaga acttcatcat      120

caagatgtct gatgatattg actggttacg cagccacagg ggtgtgtgca aggtagatct      180

ctacaaccca gaaggacagc aagatcagga ccggaaagtg atatgctttg tcgatgtgtc      240

caccctgaat gtagaagata aagattacaa ggatgctgct agttccagct cagaaggcaa      300

cttaaacctg ggaagtctgg aagaaaaaga gattatcgtg atcaaggaca ctgagaagaa      360

agaccagtct aagacagagg gatctgtatg ccttttcaaa caagctccct ctgatcctgt      420

aagtgtcctc aactggcttc tcagtgatct ccagaagtat gccttgggtt tccaacatgc      480

actgagcccc tcaacctcta cctgtaaaca taaagtagga gacacagagg gcgaatatca      540

cagagcatcc tctgagaact gctacagtgt ctatgccgat caagtgaaca tagattattt      600

gatgaacaga cctcaaaacc tacgtctaga aatgacagca gctaaaaaca ccaacaataa      660

tcaaagtcct tcagctcctc cagccaaacc tcctagcact cagagagcag tcatttcccc      720

tgatggagaa tgttctatag atgacctttc cttctacgtc aaccgactat cttctctggt      780

aatccagatg gcccataagg aaatcaagga gaagttggaa ggtaaaagca aatgccttca      840

tcattcaatc tgtccatccc ctgggaacaa agagagaatc agtccccgaa ctcctgcgag      900

caagattgct tctgaaatgg cctatgaagc tgtggaactg acagctgcag aaatgcgtgg      960

cactggagag gagtccaggg aaggtggcca gaaaagcttt ctatatagcg aattatccaa     1020

caagagcaaa agtggagaca aacagatgtc ccagagagag agcaaagaat ttgcagattc     1080

catcagcaag gggctcatgg tttatgcaaa tcaggtggca tctgacatga tggtctctct     1140

catgaagacc ttgaaagtgc acagctctgg gaagccaatt ccagcatctg tggtcctgaa     1200

gagggtgttg ctaaggcaca ccaaggagat tgtgtccgat ttgattgatt cttgcatgaa     1260

gaacctgcat aatattactg gggtcctgat gactgactca gactttgtct cagctgtcaa     1320

gagaaatctg ttcaaccagt ggaaacaaaa tgctacagac atcatggagg ccatgctgaa     1380

gcgcttggtc agtgccctta taggtgagga gaaggagact aagtctcaga gtctgtcata     1440

tgcatcttta aaagctgggt cccatgatcc caaatgcagg aatcagagtc ttgaattctc     1500

caccatgaaa gctgaaatga aagagaggga caaaggcaaa atgaaatcag acccatgcaa     1560

gtcactgact agtgctgaga aagtcggtga acacattctc aaagagggcc taaccatctg     1620

gaaccaaaag caaggaaact catgcaaggt ggctaccaaa gcatgcagca ataaagatga     1680

gaaaggagaa aagatcaatg cttccacaga ttcactggcc aaggacctga ttgtctctgc     1740

ccttaagctg atccagtacc atctgaccca gcagactaag ggcaaagata catgtgaaga     1800

agactgtcct ggttccacca tgggctatat ggctcagagt actcaatatg aaaagtgtgg     1860

aggtggccaa agtgccaaag cactttcagt gaaacaacta gaatctcaca gagcccctgg     1920

accatccacc tgtcaaaagg agaaccaaca cctggactcc cagaaaatgg atatgtcaaa     1980

catcgttcta atgctgattc agaaactgct taatgagaac cccttcaaat gtgaggatcc     2040

atgcgaaggt gagaacaagt gttctgagcc cagggcaagc aaagcagctt ccatgtccaa     2100

cagatctgac aaagcggaag aacaatgcca ggagcatcaa gaacttgact gtaccagtgg     2160

gatgaagcaa gcgaacgggc aatttataga taaactagta gaatctgtga tgaagctctg     2220

ccttatcatg gctaagtata gcaacgatgg ggcagccctt gctgagttgg aagaacaagc     2280

agcctcggca aataagccca atttcagggg caccagatgc attcacagtg gtgcaatgcc     2340

acagaactat caagactctc ttggacatga agtaattgtc aataatcagt gctctacaaa     2400

tagcttgcag aagcagctcc aggctgtcct gcagtggatt gcagcctccc agtttaacgt     2460

gcccatgctc tacttcatgg gagataagga tggacaactg gaaaagcttc ctcaggtttc     2520

agctaaagca gcagagaagg ggtacagtgt aggaggtctt cttcaagagg tcatgaagtt     2580

tgccaaggaa cggcaaccag atgaagctgt gggaaaggtg gccaggaaac agttgctgga     2640

ctggctgctc gctaacctgt gagctgatcc ttgactcctc ttcatcttag cccccctagc     2700

agcattccat cccagccaga gcacccccac catcaggcca gtcaactgca caatacacaa     2760

ctgtatttcc caatacactt gagcagttgc ctgtgaatgt aagaggtgtc aacaaactgg     2820

gaaataaaat aaaaaaaaat aataaaaaaa aaaaaaaaaa aaaaaaa                   2867


<210>  4
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Asp Asp Ile Asp Trp Leu Arg Ser His Arg Gly Val Cys Lys 
1               5                   10                  15      


Val Asp Leu Tyr Asn Pro Glu Gly Gln Gln Asp Gln Asp Arg Lys Val 
            20                  25                  30          


Ile Cys Phe Val Asp Val Ser Thr Leu Asn Val Glu Asp Lys Asp Tyr 
        35                  40                  45              


Lys Asp Ala Ala Ser Ser Ser Ser Glu Gly Asn Leu Asn Leu Gly Ser 
    50                  55                  60                  


Leu Glu Glu Lys Glu Ile Ile Val Ile Lys Asp Thr Glu Lys Lys Asp 
65                  70                  75                  80  


Gln Ser Lys Thr Glu Gly Ser Val Cys Leu Phe Lys Gln Ala Pro Ser 
                85                  90                  95      


Asp Pro Val Ser Val Leu Asn Trp Leu Leu Ser Asp Leu Gln Lys Tyr 
            100                 105                 110         


Ala Leu Gly Phe Gln His Ala Leu Ser Pro Ser Thr Ser Thr Cys Lys 
        115                 120                 125             


His Lys Val Gly Asp Thr Glu Gly Glu Tyr His Arg Ala Ser Ser Glu 
    130                 135                 140                 


Asn Cys Tyr Ser Val Tyr Ala Asp Gln Val Asn Ile Asp Tyr Leu Met 
145                 150                 155                 160 


Asn Arg Pro Gln Asn Leu Arg Leu Glu Met Thr Ala Ala Lys Asn Thr 
                165                 170                 175     


Asn Asn Asn Gln Ser Pro Ser Ala Pro Pro Ala Lys Pro Pro Ser Thr 
            180                 185                 190         


Gln Arg Ala Val Ile Ser Pro Asp Gly Glu Cys Ser Ile Asp Asp Leu 
        195                 200                 205             


Ser Phe Tyr Val Asn Arg Leu Ser Ser Leu Val Ile Gln Met Ala His 
    210                 215                 220                 


Lys Glu Ile Lys Glu Lys Leu Glu Gly Lys Ser Lys Cys Leu His His 
225                 230                 235                 240 


Ser Ile Cys Pro Ser Pro Gly Asn Lys Glu Arg Ile Ser Pro Arg Thr 
                245                 250                 255     


Pro Ala Ser Lys Ile Ala Ser Glu Met Ala Tyr Glu Ala Val Glu Leu 
            260                 265                 270         


Thr Ala Ala Glu Met Arg Gly Thr Gly Glu Glu Ser Arg Glu Gly Gly 
        275                 280                 285             


Gln Lys Ser Phe Leu Tyr Ser Glu Leu Ser Asn Lys Ser Lys Ser Gly 
    290                 295                 300                 


Asp Lys Gln Met Ser Gln Arg Glu Ser Lys Glu Phe Ala Asp Ser Ile 
305                 310                 315                 320 


Ser Lys Gly Leu Met Val Tyr Ala Asn Gln Val Ala Ser Asp Met Met 
                325                 330                 335     


Val Ser Leu Met Lys Thr Leu Lys Val His Ser Ser Gly Lys Pro Ile 
            340                 345                 350         


Pro Ala Ser Val Val Leu Lys Arg Val Leu Leu Arg His Thr Lys Glu 
        355                 360                 365             


Ile Val Ser Asp Leu Ile Asp Ser Cys Met Lys Asn Leu His Asn Ile 
    370                 375                 380                 


Thr Gly Val Leu Met Thr Asp Ser Asp Phe Val Ser Ala Val Lys Arg 
385                 390                 395                 400 


Asn Leu Phe Asn Gln Trp Lys Gln Asn Ala Thr Asp Ile Met Glu Ala 
                405                 410                 415     


Met Leu Lys Arg Leu Val Ser Ala Leu Ile Gly Glu Glu Lys Glu Thr 
            420                 425                 430         


Lys Ser Gln Ser Leu Ser Tyr Ala Ser Leu Lys Ala Gly Ser His Asp 
        435                 440                 445             


Pro Lys Cys Arg Asn Gln Ser Leu Glu Phe Ser Thr Met Lys Ala Glu 
    450                 455                 460                 


Met Lys Glu Arg Asp Lys Gly Lys Met Lys Ser Asp Pro Cys Lys Ser 
465                 470                 475                 480 


Leu Thr Ser Ala Glu Lys Val Gly Glu His Ile Leu Lys Glu Gly Leu 
                485                 490                 495     


Thr Ile Trp Asn Gln Lys Gln Gly Asn Ser Cys Lys Val Ala Thr Lys 
            500                 505                 510         


Ala Cys Ser Asn Lys Asp Glu Lys Gly Glu Lys Ile Asn Ala Ser Thr 
        515                 520                 525             


Asp Ser Leu Ala Lys Asp Leu Ile Val Ser Ala Leu Lys Leu Ile Gln 
    530                 535                 540                 


Tyr His Leu Thr Gln Gln Thr Lys Gly Lys Asp Thr Cys Glu Glu Asp 
545                 550                 555                 560 


Cys Pro Gly Ser Thr Met Gly Tyr Met Ala Gln Ser Thr Gln Tyr Glu 
                565                 570                 575     


Lys Cys Gly Gly Gly Gln Ser Ala Lys Ala Leu Ser Val Lys Gln Leu 
            580                 585                 590         


Glu Ser His Arg Ala Pro Gly Pro Ser Thr Cys Gln Lys Glu Asn Gln 
        595                 600                 605             


His Leu Asp Ser Gln Lys Met Asp Met Ser Asn Ile Val Leu Met Leu 
    610                 615                 620                 


Ile Gln Lys Leu Leu Asn Glu Asn Pro Phe Lys Cys Glu Asp Pro Cys 
625                 630                 635                 640 


Glu Gly Glu Asn Lys Cys Ser Glu Pro Arg Ala Ser Lys Ala Ala Ser 
                645                 650                 655     


Met Ser Asn Arg Ser Asp Lys Ala Glu Glu Gln Cys Gln Glu His Gln 
            660                 665                 670         


Glu Leu Asp Cys Thr Ser Gly Met Lys Gln Ala Asn Gly Gln Phe Ile 
        675                 680                 685             


Asp Lys Leu Val Glu Ser Val Met Lys Leu Cys Leu Ile Met Ala Lys 
    690                 695                 700                 


Tyr Ser Asn Asp Gly Ala Ala Leu Ala Glu Leu Glu Glu Gln Ala Ala 
705                 710                 715                 720 


Ser Ala Asn Lys Pro Asn Phe Arg Gly Thr Arg Cys Ile His Ser Gly 
                725                 730                 735     


Ala Met Pro Gln Asn Tyr Gln Asp Ser Leu Gly His Glu Val Ile Val 
            740                 745                 750         


Asn Asn Gln Cys Ser Thr Asn Ser Leu Gln Lys Gln Leu Gln Ala Val 
        755                 760                 765             


Leu Gln Trp Ile Ala Ala Ser Gln Phe Asn Val Pro Met Leu Tyr Phe 
    770                 775                 780                 


Met Gly Asp Lys Asp Gly Gln Leu Glu Lys Leu Pro Gln Val Ser Ala 
785                 790                 795                 800 


Lys Ala Ala Glu Lys Gly Tyr Ser Val Gly Gly Leu Leu Gln Glu Val 
                805                 810                 815     


Met Lys Phe Ala Lys Glu Arg Gln Pro Asp Glu Ala Val Gly Lys Val 
            820                 825                 830         


Ala Arg Lys Gln Leu Leu Asp Trp Leu Leu Ala Asn Leu 
        835                 840                 845 


<210>  5
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  5
tcctacatga tggcgtactc tg                                                22


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  6
aagttgcctt ctgagctgga ac                                                22


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
gggtgtgtgc aaggtagatc tct                                               23


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
cacatcgaca aagcatatca ctttc                                             25


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
gccataccac cctgaacg                                                     18


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
agcctacagc acccggtatt                                                   20


