                         SEQUENCE LISTING

<110>  University of Oslo
       Wlchli, Sebastien  P
       Gregers, Tone F
       Gaudernack, Gustav
       Kvalheim, Gunnar
       Bakke, Oddmund
       Inderberg, Else M.S.
 
<120>  Engineered invariant chain molecule for improved MHC class I 
       loading

<130>  54081PC01

<150>  14171798.3
<151>  2014-06-10

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
1               5                   10                  15      


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
            20                  25                  30          


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
        35                  40                  45              


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
    50                  55                  60                  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
65                  70                  75                  80  


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
                85                  90                  95      


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
            100                 105                 110         


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
        115                 120                 125             


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
    130                 135                 140                 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
145                 150                 155                 160 


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
                165                 170                 175     


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
            180                 185                 190         


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
        195                 200                 205             


Gln Asp Leu Gly Pro Val Pro Met 
    210                 215     


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Met Arg Met Ala Thr Pro Leu Leu Met 
1               5                   


<210>  3
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
1               5                   10                  15      


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
            20                  25                  30          


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
        35                  40                  45              


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
    50                  55                  60                  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
65                  70                  75                  80  


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Arg Leu Ser Ser Cys Val 
                85                  90                  95      


Pro Val Ala Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
            100                 105                 110         


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
        115                 120                 125             


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
    130                 135                 140                 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
145                 150                 155                 160 


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
                165                 170                 175     


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
            180                 185                 190         


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
        195                 200                 205             


Gln Asp Leu Gly Pro Val Pro Met 
    210                 215     


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Arg Leu Ser Ser Cys Val Pro Val Ala 
1               5                   


<210>  5
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5

Met Asp Asp Arg Arg Pro Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
1               5                   10                  15      


Ala Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
            20                  25                  30          


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
        35                  40                  45              


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
    50                  55                  60                  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
65                  70                  75                  80  


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Arg Leu Ser Ser Cys Val 
                85                  90                  95      


Pro Val Ala Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
            100                 105                 110         


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
        115                 120                 125             


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
    130                 135                 140                 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
145                 150                 155                 160 


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
                165                 170                 175     


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
            180                 185                 190         


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
        195                 200                 205             


Gln Asp Leu Gly Pro Val Pro Met 
    210                 215     


<210>  6
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
1               5                   10                  15      


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
            20                  25                  30          


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
        35                  40                  45              


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
    50                  55                  60                  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
65                  70                  75                  80  


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Lys Ser Leu Val Arg Leu 
                85                  90                  95      


Ser Ser Cys Val Pro Val Ala Leu Met Ser Ala Met Thr Gln Ala Leu 
            100                 105                 110         


Pro Met Gly Ala Leu Pro Gln Gly Pro Met Gln Asn Ala Thr Lys Tyr 
        115                 120                 125             


Gly Asn Met Thr Glu Asp His Val Met His Leu Leu Gln Asn Ala Asp 
    130                 135                 140                 


Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly Ser Phe Pro Glu Asn Leu 
145                 150                 155                 160 


Arg His Leu Lys Asn Thr Met Glu Thr Ile Asp Trp Lys Val Phe Glu 
                165                 170                 175     


Ser Trp Met His His Trp Leu Leu Phe Glu Met Ser Arg His Ser Leu 
            180                 185                 190         


Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys Glu Ser Leu Glu Leu Glu 
        195                 200                 205             


Asp Pro Ser Ser Gly Leu Gly Val Thr Lys Gln Asp Leu Gly Pro Val 
    210                 215                 220                 


Pro Met 
225     


<210>  7
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7

Lys Ser Leu Val Arg Leu Ser Ser Cys Val Pro Val Ala Leu Met Ser 
1               5                   10                  15      


Ala Met Thr 
            


<210>  8
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
1               5                   10                  15      


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
            20                  25                  30          


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
        35                  40                  45              


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
    50                  55                  60                  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
65                  70                  75                  80  


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Ser Leu Val Arg Leu Ser 
                85                  90                  95      


Ser Cys Val Pro Val Ala Leu Met Ser Ala Met Thr Thr Ser Ser Ser 
            100                 105                 110         


Gln Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met Gln Asn 
        115                 120                 125             


Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His Leu Leu 
    130                 135                 140                 


Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly Ser Phe 
145                 150                 155                 160 


Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile Asp Trp 
                165                 170                 175     


Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu Met Ser 
            180                 185                 190         


Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys Glu Ser 
        195                 200                 205             


Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys Gln Asp 
    210                 215                 220                 


Leu Gly Pro Val Pro Met 
225                 230 


<210>  9
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9

Ser Leu Val Arg Leu Ser Ser Cys Val Pro Val Ala Leu Met Ser Ala 
1               5                   10                  15      


Met Thr Thr Ser Ser Gln 
            20          


<210>  10
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10
agagagggta ccgtcatgga tgaccagcgc gac                                    33


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11
agagagggat cctcacatgg ggactgggcc cag                                    33


<210>  12
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12
ccgtcatgga tgaccgtcgt ccccttatct ccaacaatg                              39


<210>  13
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13
cattgttgga gataagggga cgacggtcat ccatgacgg                              39


<210>  14
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14
gctcgagtgc tgcggtaccc ttgctcacag gcttggg                                37


<210>  15
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15
caagagcctg gtgagactga gcagctgcgt gcccgtggcc ctgatgagcg ccatgaccc        59


<210>  16
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16
tcgagggtca tggcgctcat cagggccacg ggcacgcagc tgctcagtct caccaggctc       60

ttggtac                                                                 67


<210>  17
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17
cagcctggtg agactgagca gctgcgtgcc cgtggccctg atgagcgcca tgaccaccag       60

cagcagccag c                                                            71


<210>  18
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18
tcgagctggc tgctgctggt ggtcatggcg ctcatcaggg ccacgggcac gcagctgctc       60

agtctcacca ggctggtac                                                    79


<210>  19
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19
ggtaccgcag cactcgagca gaatgccacc aagtatggc                              39


<210>  20
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20

Met Asp Asp Gln Arg Asp Ala Ile Ser Asn Asn Glu Gln Leu Pro Met 
1               5                   10                  15      


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg 
            20                  25                  30  


<210>  21
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
1               5                   10                  15      


Ala Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg 
            20                  25                  30  


<210>  22
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Met Asp Asp Gln Arg Asp Ala Ile Ser Asn Asn Glu Gln Leu Pro Met 
1               5                   10                  15      


Ala Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg 
            20                  25                  30  


<210>  23
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23

Met Asp Asp Gln Arg Asp Ala Ile Ser Asn Asn Glu Arg Ala Pro Met 
1               5                   10                  15      


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg 
            20                  25                  30  


<210>  24
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24

Met Asp Asp Gln Arg Asp Ala Ile Ser Asn Asn Glu Arg Arg Pro Met 
1               5                   10                  15      


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg 
            20                  25                  30  


<210>  25
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25

Met Asp Asp Arg Ala Pro Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
1               5                   10                  15      


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg 
            20                  25                  30  


