                         SEQUENCE LISTING

<110>  RSR Ltd
 
<120>  Glycoprotein Hormone Receptor Mutations

<130>  CRT/JAA/29903 GB

<160>  108   

<170>  PatentIn version 3.5

<210>  1
<211>  2295
<212>  DNA
<213>  Homo sapiens

<400>  1
atgaggccgg cggacttgct gcagctggtg ctgctgctcg acctgcccag ggacctgggc       60

ggaatggggt gttcgtctcc accctgcgag tgccatcagg aggaggactt cagagtcacc      120

tgcaaggata ttcaacgcat ccccagctta ccgcccagta cgcagactct gaagcttatt      180

gagactcacc tgagaactat tccaagtcat gcattttcta atctgcccaa tatttccaga      240

atctacgtat ctatagatgt gactctgcag cagctggaat cacactcctt ctacaatttg      300

agtaaagtga ctcacataga aattcggaat accaggaact taacttacat agaccctgat      360

gccctcaaag agctccccct cctaaagttc cttggcattt tcaacactgg acttaaaatg      420

ttccctgacc tgaccaaagt ttattccact gatatattct ttatacttga aattacagac      480

aacccttaca tgacgtcaat ccctgtgaat gcttttcagg gactatgcaa tgaaaccttg      540

acactgaagc tgtacaacaa cggctttact tcagtccaag gatatgcttt caatgggaca      600

aagctggatg ctgtttacct aaacaagaat aaatacctga cagttattga caaagatgca      660

tttggaggag tatacagtgg accaagcttg ctggacgtgt ctcaaaccag tgtcactgcc      720

cttccatcca aaggcctgga gcacctgaag gaactgatag caagaaacac ctggactctt      780

aagaaacttc cactttcctt gagtttcctt cacctcacac gggctgacct ttcttaccca      840

agccactgct gtgcctttaa gaatcagaag aaaatcagag gaatccttga gtccttgatg      900

tgtaatgaga gcagtatgca gagcttgcgc cagagaaaat ctgtgaatgc cttgaatagc      960

cccctccacc aggaatatga agagaatctg ggtgacagca ttgttgggta caaggaaaag     1020

tccaagttcc aggatactca taacaacgct cattattacg tcttctttga agaacaagag     1080

gatgagatca ttggttttgg ccaggagctc aaaaaccccc aggaagagac tctacaagct     1140

tttgacagcc attatgacta caccatatgt ggggacagtg aagacatggt gtgtaccccc     1200

aagtccgatg agttcaaccc gtgtgaagac ataatgggct acaagttcct gagaattgtg     1260

gtgtggttcg ttagtctgct ggctctcctg ggcaatgtct ttgtcctgct tattctcctc     1320

accagccact acaaactgaa cgtcccccgc tttctcatgt gcaacctggc ctttgcggat     1380

ttctgcatgg ggatgtacct gctcctcatc gcctctgtag acctctacac tcactctgag     1440

tactacaacc atgccatcga ctggcagaca ggccctgggt gcaacacggc tggtttcttc     1500

actgtctttg caagcgagtt atcggtgtat acgctgacgg tcatcaccct ggagcgctgg     1560

tatgccatca ccttcgccat gcgcctggac cggaagatcc gcctcaggca cgcatgtgcc     1620

atcatggttg ggggctgggt ttgctgcttc cttctcgccc tgcttccttt ggtgggaata     1680

agtagctatg ccaaagtcag tatctgcctg cccatggaca ccgagacccc tcttgctctg     1740

gcatatattg tttttgttct gacgctcaac atagttgcct tcgtcatcgt ctgctgctgt     1800

tatgtgaaga tctacatcac agtccgaaat ccgcagtaca acccagggga caaagatacc     1860

aaaattgcca agaggatggc tgtgttgatc ttcaccgact tcatatgcat ggccccaatc     1920

tcattctatg ctctgtcagc aattctgaac aagcctctca tcactgttag caactccaaa     1980

atcttgctgg tactcttcta tccacttaac tcctgtgcca atccattcct ctatgctatt     2040

ttcaccaagg ccttccagag ggatgtgttc atcctactca gcaagtttgg catctgtaaa     2100

cgccaggctc aggcataccg ggggcagagg gttcctccaa agaacagcac tgatattcag     2160

gttcaaaagg ttacccacga gatgaggcag ggtctccaca acatggaaga tgtctatgaa     2220

ctgattgaaa agtcccatct aaccccaaag aagcaaggcc aaatctcaga agagtatatg     2280

caaacggttt tgtaa                                                      2295


<210>  2
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Asp Leu Pro 
1               5                   10                  15      


Arg Asp Leu Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Val Ser Ile Asp Leu Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Met Gln Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn Ser 
305                 310                 315                 320 


Pro Leu His Gln Glu Tyr Glu Glu Asn Leu Gly Asp Ser Ile Val Gly 
                325                 330                 335     


Tyr Lys Glu Lys Ser Lys Phe Gln Asp Thr His Asn Asn Ala His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Ile Cys Gly Asp Ser Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Leu Ile Leu Leu Thr Ser His Tyr Lys Leu Asn Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Cys Ala Ile Met Val Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Val Phe Val Leu Thr Leu Asn Ile Val 
            580                 585                 590         


Ala Phe Val Ile Val Cys Cys Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Ile Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Ile Leu Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Ser Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Pro Pro Lys Asn Ser Thr Asp Ile Gln 
705                 710                 715                 720 


Val Gln Lys Val Thr His Asp Met Arg Gln Gly Leu His Asn Met Glu 
                725                 730                 735     


Asp Val Tyr Glu Leu Ile Glu Asn Ser His Leu Thr Pro Lys Lys Gln 
            740                 745                 750         


Gly Gln Ile Ser Glu Glu Tyr Met Gln Thr Val Leu 
        755                 760                 


<210>  3
<211>  780
<212>  DNA
<213>  Homo sapiens

<400>  3
atgaggccgg cggacttgct gcagctggtg ctgctgctcg acctgcccag ggacctgggc       60

ggaatggggt gttcgtctcc accctgcgag tgccatcagg aggaggactt cagagtcacc      120

tgcaaggata ttcaacgcat ccccagctta ccgcccagta cgcagactct gaagcttatt      180

gagactcacc tgagaactat tccaagtcat gcattttcta atctgcccaa tatttccaga      240

atctacgtat ctatagatgt gactctgcag cagctggaat cacactcctt ctacaatttg      300

agtaaagtga ctcacataga aattcggaat accaggaact taacttacat agaccctgat      360

gccctcaaag agctccccct cctaaagttc cttggcattt tcaacactgg acttaaaatg      420

ttccctgacc tgaccaaagt ttattccact gatatattct ttatacttga aattacagac      480

aacccttaca tgacgtcaat ccctgtgaat gcttttcagg gactatgcaa tgaaaccttg      540

acactgaagc tgtacaacaa cggctttact tcagtccaag gatatgcttt caatgggaca      600

aagctggatg ctgtttacct aaacaagaat aaatacctga cagttattga caaagatgca      660

tttggaggag tatacagtgg accaagcttg ctggacgtgt ctcaaaccag tgtcactgcc      720

cttccatcca aaggcctgga gcacctgaag gaactgatag caagaaacac ctggactctt      780


<210>  4
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Asp Leu Pro 
1               5                   10                  15      


Arg Asp Leu Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Val Ser Ile Asp Leu Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu 
            260 


<210>  5
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  5
cactgcagga tccaaatgag gccggcggac ttg                                    33


<210>  6
<211>  62
<212>  DNA
<213>  Homo sapiens

<400>  6
cagtcctcta gattatcagt gatggtggtg gtgatggtta agagtccagg tgttcttgct       60

at                                                                      62


<210>  7
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  7
cactgcgaat tcaaaatgag gccggcggac ttgctg                                 36


<210>  8
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  8
gttctcctcc tcaactggga tgatgttaag agtccaggtg tttcttgc                    48


<210>  9
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  9
gcaagaaaca cctggactct taacatcatc ccagttgagg aggagaac                    48


<210>  10
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  10
taatacgact cactataggg                                                   20


<210>  11
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  11
ggaatggggt gttcgtctcc agagtgcgag tgccatcagg aggag                       45


<210>  12
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  12
cccagtacgc agactctgaa gttcattgag actcacctga gaact                       45


<210>  13
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  13
cagactctga agcttattga ggtgcacctg agaactattc caagt                       45


<210>  14
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  14
actctgaagc ttattgagac ttgcctgaga actattccaa gtcat                       45


<210>  15
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  15
ctgaagctta ttgagactca ctacagaact attccaagtc atgca                       45


<210>  16
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  16
cacatagaaa ttcggaatac ccccaactta acttacatag accct                       45


<210>  17
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  17
aacactggac ttaaaatgtt catcgacctg accaaagttt attcc                       45


<210>  18
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  18
actggactta aaatgttccc tcccctgacc aaagtttatt ccact                       45


<210>  19
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  19
ctgaccaaag tttattccac tgagatattc tttatacttg aaatt                       45


<210>  20
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  20
acagacaacc cttacatgac gaccatccct gtgaatgctt ttcag                       45


<210>  21
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  21
gacaaccctt acatgacgtc attccctgtg aatgcttttc aggga                       45


<210>  22
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  22
aacccttaca tgacgtcaat ctacgtgaat gcttttcagg gacta                       45


<210>  23
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  23
ccttacatga cgtcaatccc taggaatgct tttcagggac tatgc                       45


<210>  24
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  24
tacatgacgt caatccctgt gtgggctttt cagggactat gcaat                       45


<210>  25
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  25
tttcagggac tatgcaatga atgcttgaca ctgaagctgt acaac                       45


<210>  26
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  26
ctgtacaaca acggctttac tgaggtccaa ggatatgctt tcaat                       45


<210>  27
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  27
ctggagcacc tgaaggaact gagagcaaga aacacctgga ctctt                       45


<210>  28
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  28
cacctgaagg aactgatagc atacaacacc tggactctt                              39


<210>  29
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Met Gly Cys Ser Ser Pro Glu Cys Glu Cys His Gln Glu Glu 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  30

Pro Ser Thr Gln Thr Leu Lys Phe Ile Glu Thr His Leu Arg Thr 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Thr Leu Lys Leu Ile Glu Val His Leu Arg Thr Ile Pro Ser 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  32

Thr Leu Lys Leu Ile Glu Thr Cys Leu Arg Thr Ile Pro Ser His 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  33

Leu Lys Leu Ile Glu Thr His Tyr Arg Thr Ile Pro Ser His Ala 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  34

His Ile Glu Ile Arg Asn Thr Pro Asn Leu Thr Tyr Ile Asp Pro 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  35

Asn Thr Gly Leu Lys Met Phe Ile Asp Leu Thr Lys Val Tyr Ser 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  36

Thr Gly Leu Lys Met Phe Pro Pro Leu Thr Lys Val Tyr Ser Thr 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  37

Leu Thr Lys Val Tyr Ser Thr Glu Ile Phe Phe Ile Leu Glu Ile 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  38

Thr Asp Asn Pro Tyr Met Thr Thr Ile Pro Val Asn Ala Phe Gln 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  39

Asp Asn Pro Tyr Met Thr Ser Phe Pro Val Asn Ala Phe Gln Gly 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  40

Asn Pro Tyr Met Thr Ser Ile Tyr Val Asn Ala Phe Gln Gly Leu 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  41

Pro Tyr Met Thr Ser Ile Pro Arg Asn Ala Phe Gln Gly Leu Cys 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  42

Tyr Met Thr Ser Ile Pro Val Trp Ala Phe Gln Gly Leu Cys Asn 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  43

Phe Gln Gly Leu Cys Asn Glu Cys Leu Thr Leu Lys Leu Tyr Asn 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  44

Leu Tyr Asn Asn Gly Phe Thr Glu Val Gln Gly Tyr Ala Phe Asn 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  45

Leu Glu His Leu Lys Glu Leu Arg Ala Arg Asn Thr Trp Thr Leu 
1               5                   10                  15  


<210>  46
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  46

His Leu Lys Glu Leu Ile Ala Tyr Asn Thr Trp Thr Leu 
1               5                   10              


<210>  47
<211>  764
<212>  PRT
<213>  Cercopithecus aethiops

<400>  47

Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Val Leu Pro 
1               5                   10                  15      


Arg Asp Leu Gly Gly Lys Gly Cys Ser Ser Pro Pro Cys Glu Cys Gln 
            20                  25                  30          


Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr Arg Leu 
    50                  55                  60                  


Arg Thr Ile Pro Ser His Ala Phe Ser Ser Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Ala Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Asn Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Ser Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Ile 
            180                 185                 190         


Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser His Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Met Gln Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn Ser 
305                 310                 315                 320 


Pro Leu His Gln Glu Tyr Glu Glu Asn Leu Asp Asp Gly Ile Val Gly 
                325                 330                 335     


Tyr Lys Glu Lys Ser Lys Phe Gln Asp Ala His Asn Asn Ala His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Asp Asn Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Leu Ile Leu Leu Thr Ser His Tyr Lys Leu Asn Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Cys Ala Ile Met Val Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Val Phe Val Leu Thr Leu Asn Ile Val 
            580                 585                 590         


Ala Phe Val Ile Val Cys Cys Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Met Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Ile Leu Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Ser Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Pro Pro Lys Asn Ser Thr Asp Ile Gln 
705                 710                 715                 720 


Val Gln Lys Val Thr His Glu Met Arg Gln Gly Leu His Asn Met Glu 
                725                 730                 735     


Asp Val Tyr Glu Leu Ile Glu Asn Ser His Leu Thr Pro Lys Lys Gln 
            740                 745                 750         


Gly Gln Ile Ser Glu Glu Tyr Thr Gln Thr Val Leu 
        755                 760                 


<210>  48
<211>  764
<212>  PRT
<213>  Macaca mulatta

<400>  48

Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Val Leu Pro 
1               5                   10                  15      


Arg Asp Leu Gly Gly Lys Gly Cys Ser Ser Pro Pro Cys Glu Cys Gln 
            20                  25                  30          


Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr Arg Leu 
    50                  55                  60                  


Arg Thr Ile Pro Ser His Ala Phe Ser Ser Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Ala Thr Leu Gln Gln Leu Glu Thr His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Asn Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Ser Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Ile 
            180                 185                 190         


Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser His Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Pro Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Met Gln Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn Ser 
305                 310                 315                 320 


Pro Leu His Gln Glu Tyr Glu Glu Asn Leu Asp Asp Gly Ile Val Gly 
                325                 330                 335     


Tyr Lys Glu Lys Ser Lys Phe Gln Asp Ala His Asn Asn Ala His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Asp Asn Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Leu Ile Leu Leu Thr Ser His Tyr Lys Leu Asn Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Cys Ala Ile Met Val Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Val Phe Val Leu Thr Leu Asn Ile Val 
            580                 585                 590         


Ala Phe Val Ile Val Cys Cys Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Ile Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Ile Leu Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Ser Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Pro Pro Lys Asn Ser Thr Asp Ile Gln 
705                 710                 715                 720 


Val Gln Lys Val Thr His Glu Met Arg Gln Asp Leu His Asn Met Gln 
                725                 730                 735     


Asp Val Tyr Glu Leu Leu Glu Asn Ser His Leu Thr Pro Lys Lys Gln 
            740                 745                 750         


Gly Gln Ile Ser Glu Glu Tyr Thr Gln Thr Val Leu 
        755                 760                 


<210>  49
<211>  764
<212>  PRT
<213>  Sus scrofa

<400>  49

Met Ser Leu Thr Pro Leu Leu Gln Leu Ala Leu Val Leu Ala Leu Pro 
1               5                   10                  15      


Arg Ser Leu Arg Gly Lys Gly Cys Pro Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Asp Asp Phe Arg Val Thr Cys Lys Asp Ile His Ser Ile Pro 
        35                  40                  45              


Pro Leu Pro Pro Asn Thr Gln Thr Leu Lys Phe Ile Glu Thr His Leu 
    50                  55                  60                  


Lys Thr Ile Pro Ser Arg Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Ala Thr Leu Gln Gln Leu Glu Ser Gln Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Met Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Ser Leu Thr Tyr Ile Asn Pro Gly Ala Leu Lys Asp Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Arg Ile Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Val Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Ala Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly His Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Phe Ser Gly Pro Thr Leu Leu Asp Val Ser Tyr Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Pro Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Ile Arg Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Val Asn Gly 
305                 310                 315                 320 


Pro Phe Tyr Gln Glu Tyr Glu Glu Asp Leu Gly Asp Thr Ser Val Gly 
                325                 330                 335     


Asn Lys Glu Asn Ser Lys Phe Gln Asp Thr His Ser Asn Ser His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Gly Ser Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Arg Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Val Ile Leu Leu Thr Ser His Tyr Lys Leu Thr Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr Gln Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Tyr Ala Ile Met Ala Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Ile Leu Val Leu Leu Leu Asn Ile Val 
            580                 585                 590         


Ala Phe Thr Ile Val Cys Ser Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Met Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Leu Met Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Thr Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Phe Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Ser Pro Lys Asn Ser Thr Gly Ile Gln 
705                 710                 715                 720 


Val Gln Lys Val Thr Gln Asn Met Arg Gln Ser Leu Pro Asn Met Gln 
                725                 730                 735     


Asp Asp Tyr Glu Leu Leu Glu Asn Ser His Leu Thr His Lys Lys His 
            740                 745                 750         


Asp Gln Ile Ser Lys Glu Tyr Lys Gln Thr Val Leu 
        755                 760                 


<210>  50
<211>  764
<212>  PRT
<213>  Bos taurus


<220>
<221>  misc_feature
<222>  (329)..(329)
<223>  Xaa can be any naturally occurring amino acid

<400>  50

Met Arg Pro Thr Pro Leu Leu Arg Leu Ala Leu Phe Leu Val Leu Pro 
1               5                   10                  15      


Ser Ser Leu Gly Gly Glu Arg Cys Pro Ser Pro Pro Cys Glu Cys Arg 
            20                  25                  30          


Gln Glu Asp Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Ser Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Phe Ile Glu Thr His Leu 
    50                  55                  60                  


Lys Thr Ile Pro Ser Arg Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Ala Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Ser Leu Thr Tyr Ile Asp Ser Gly Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Arg Val Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Ile Tyr Ser Thr Asp Val Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Ala Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Ile 
            180                 185                 190         


Gln Gly His Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Gly Gln Asp Ala Phe Ala Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Thr Leu Leu Asp Ile Ser Tyr Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Arg Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Gln Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Ile Arg Gly Leu Arg Gln Arg Lys Ser Ala Ser Ala Leu Asn Gly 
305                 310                 315                 320 


Pro Phe Tyr Gln Glu Tyr Glu Asp Xaa Leu Gly Asp Gly Ser Ala Gly 
                325                 330                 335     


Tyr Lys Glu Asn Ser Lys Phe Gln Asp Thr Gln Ser Asn Ser His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Gln Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Gly Ser Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Val Ile Leu Leu Thr Ser His Tyr Lys Leu Thr Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Leu Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr Gln Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp His Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Trp His Ala Tyr Val Ile Met Leu Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Ile Leu Val Leu Leu Leu Asn Ile Ile 
            580                 585                 590         


Ala Phe Ile Ile Val Cys Ala Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro His Tyr Asn Pro Gly Asp Lys Asp Thr Arg Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Met Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Leu Met Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Thr Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Met Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Ser Pro Lys Asn Ser Thr Gly Ile Arg 
705                 710                 715                 720 


Val Gln Lys Val Pro Pro Asp Val Arg Gln Ser Leu Pro Asn Val Gln 
                725                 730                 735     


Asp Asp Tyr Glu Leu Leu Glu Asn Ser His Leu Thr Pro Lys Gln Gln 
            740                 745                 750         


Asp Gln Thr Ser Lys Glu Tyr Lys Arg Thr Val Leu 
        755                 760                 


<210>  51
<211>  764
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (360)..(360)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Met Arg Gln Thr Pro Leu Leu Gln Leu Ala Leu Leu Leu Ser Leu Pro 
1               5                   10                  15      


Arg Ser Leu Gly Gly Lys Gly Cys Pro Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Asp Asp Phe Arg Val Thr Cys Lys Asp Ile His Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Phe Ile Glu Thr His Leu 
    50                  55                  60                  


Lys Thr Ile Pro Ser Arg Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Ala Thr Leu Gln Arg Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Met Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Ser Leu Thr Tyr Ile Asp Pro Gly Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Gly Val Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Val Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Ala Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Ile 
            180                 185                 190         


Gln Gly His Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Ala Ile Asp Gln Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Thr Leu Leu Asp Val Ser Tyr Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Thr Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Phe Met Cys Asn Asp Ser 
    290                 295                 300                 


Ser Ile Arg Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn Gly 
305                 310                 315                 320 


Pro Phe Asp Gln Glu Tyr Glu Glu Tyr Leu Gly Asp Ser His Ala Gly 
                325                 330                 335     


Tyr Lys Asp Asn Ser Lys Phe Gln Asp Thr Arg Ser Asn Ser His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Xaa Asp Glu Ile Leu Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Gly Asn Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Ile Ile Leu Leu Thr Ser His Tyr Lys Leu Thr Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Ala 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Met Arg Leu Arg His Ala Tyr Ala Ile Met Val Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Ile Leu Val Leu Leu Leu Asn Ile Val 
            580                 585                 590         


Ala Phe Ile Ile Val Cys Ser Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Thr Gly Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Met Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Leu Met Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Thr Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Thr Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Ser Pro Lys Asn Ser Thr Gly Ile Gln 
705                 710                 715                 720 


Val Gln Lys Val Thr Arg Asn Met Arg Gln Ser Leu Pro Asn Met Gln 
                725                 730                 735     


Asp Asp Tyr Glu Leu Leu Glu Asn Ser His Leu Thr Pro Asn Lys Gln 
            740                 745                 750         


Ser His Ile Ser Lys Glu Tyr Asn Gln Thr Val Leu 
        755                 760                 


<210>  52
<211>  764
<212>  PRT
<213>  Canis lupus

<400>  52

Met Arg Pro Pro Pro Leu Leu His Leu Ala Leu Leu Leu Ala Leu Pro 
1               5                   10                  15      


Arg Ser Leu Gly Gly Lys Gly Cys Pro Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Asp Asp Phe Arg Val Thr Cys Lys Asp Ile His Arg Ile Pro 
        35                  40                  45              


Thr Leu Pro Pro Ser Thr Gln Thr Leu Lys Phe Ile Glu Thr Gln Leu 
    50                  55                  60                  


Lys Thr Ile Pro Ser Arg Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Ala Thr Leu Gln Arg Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Met Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Ser Leu Thr Ser Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Gly Val Phe Pro Asp Val 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Val Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Ala Ser Ile Pro Ala Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Ile 
            180                 185                 190         


Gln Gly His Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Ser Ala Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Thr Leu Leu Asp Val Ser Tyr Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Ile Arg Ser Leu Arg Gln Arg Lys Ser Val Asn Thr Leu Asn Gly 
305                 310                 315                 320 


Pro Phe Asp Gln Glu Tyr Glu Glu Tyr Leu Gly Asp Ser His Ala Gly 
                325                 330                 335     


Tyr Lys Asp Asn Ser Gln Phe Gln Asp Thr Asp Ser Asn Ser His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Leu Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Gly Asn Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Ile Val Leu Leu Thr Ser His Tyr Lys Leu Thr Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Tyr Ala Ile Met Val Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Ile Leu Val Leu Leu Leu Asn Ile Val 
            580                 585                 590         


Ala Phe Ile Ile Val Cys Ser Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Met Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Leu Met Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Thr Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Ser Pro Lys Asn Ser Ala Gly Ile Gln 
705                 710                 715                 720 


Ile Gln Lys Val Thr Arg Asp Met Arg Gln Ser Leu Pro Asn Met Gln 
                725                 730                 735     


Asp Glu Tyr Glu Leu Leu Glu Asn Ser His Leu Thr Pro Asn Lys Gln 
            740                 745                 750         


Gly Gln Ile Ser Lys Glu Tyr Asn Gln Thr Val Leu 
        755                 760                 


<210>  53
<211>  764
<212>  PRT
<213>  Mus musculus

<400>  53

Met Arg Pro Gly Ser Leu Leu Leu Leu Val Leu Leu Leu Ala Leu Ser 
1               5                   10                  15      


Arg Ser Leu Arg Gly Lys Glu Cys Ala Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Asp Asp Phe Arg Val Thr Cys Lys Glu Leu His Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Lys Thr Ile Pro Ser Leu Ala Phe Ser Ser Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Ala Thr Leu Gln Arg Leu Glu Pro His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Met Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Ser Leu Thr Tyr Ile Asp Pro Asp Ala Leu Thr Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Arg Ile Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Ile Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Val Pro Glu Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly His Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Ala Ile Asp Asn Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Thr Leu Leu Asp Val Ser Ser Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Lys Asp 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Ile Arg Asn Leu Arg Gln Arg Lys Ser Val Asn Ile Leu Arg Gly 
305                 310                 315                 320 


Pro Ile Tyr Gln Glu Tyr Glu Glu Asp Pro Gly Asp Asn Ser Val Gly 
                325                 330                 335     


Tyr Lys Gln Asn Ser Lys Phe Gln Glu Ser Pro Ser Asn Ser His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Val Val Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Glu Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Asp Asn Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Arg Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Ile Phe Val Leu Leu Ile Leu Leu Thr Ser His Tyr Lys Leu Thr Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Val Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Tyr Thr Ile Met Ala Gly 
    530                 535                 540                 


Gly Trp Val Ser Cys Phe Leu Leu Ala Leu Leu Pro Met Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Asp Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Val Leu Val Leu Leu Leu Asn Val Val 
            580                 585                 590         


Ala Phe Val Val Val Cys Ser Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Arg Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Met Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Leu Met Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Thr Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Gln Gly Gln Arg Val Cys Pro Asn Asn Ser Thr Gly Ile Gln 
705                 710                 715                 720 


Ile Gln Lys Ile Pro Gln Asp Thr Arg Gln Ser Leu Pro Asn Met Gln 
                725                 730                 735     


Asp Thr Tyr Glu Leu Leu Gly Asn Ser Gln Leu Ala Pro Lys Leu Gln 
            740                 745                 750         


Gly Gln Ile Ser Glu Glu Tyr Lys Gln Thr Ala Leu 
        755                 760                 


<210>  54
<211>  764
<212>  PRT
<213>  Rattus rattus

<400>  54

Met Arg Pro Gly Ser Leu Leu Gln Leu Thr Leu Leu Leu Ala Leu Pro 
1               5                   10                  15      


Arg Ser Leu Trp Gly Arg Gly Cys Thr Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Asp Asp Phe Arg Val Thr Cys Lys Glu Leu His Gln Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Lys Thr Ile Pro Ser Leu Ala Phe Ser Ser Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Ala Thr Leu Gln Arg Leu Glu Pro His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Met Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Ser Leu Thr Tyr Ile Asp Pro Asp Ala Leu Thr Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Arg Ile Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Ile Tyr Ser Thr Asp Val Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Val Pro Glu Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Ile 
            180                 185                 190         


Gln Gly His Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Ala Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Thr Leu Leu Asp Val Ser Ser Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Lys Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Ile Arg Asn Leu Arg Gln Arg Lys Ser Val Asn Val Met Arg Gly 
305                 310                 315                 320 


Pro Val Tyr Gln Glu Tyr Glu Glu Gly Leu Gly Asp Asn His Val Gly 
                325                 330                 335     


Tyr Lys Gln Asn Ser Lys Phe Gln Glu Gly Pro Ser Asn Ser His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Asp Asn Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Pro Met Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Phe Val Leu Leu Thr Ser His Tyr Lys Leu Thr Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Val Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Thr Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Tyr Thr Ile Met Ala Gly 
    530                 535                 540                 


Gly Trp Val Ser Cys Phe Leu Leu Ala Leu Leu Pro Met Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Asp Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Ala Leu Val Leu Leu Leu Asn Val Val 
            580                 585                 590         


Ala Phe Val Ile Val Cys Ser Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Arg Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Met Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Leu Met Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Thr Asn Ser Gly Val Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Leu Cys Lys His Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Gln Ala Gln Arg Val Cys Pro Asn Asn Asn Thr Gly Ile Gln 
705                 710                 715                 720 


Ile Gln Lys Ile Pro Gln Asp Thr Arg Gln Ser Leu Pro Asn Val Gln 
                725                 730                 735     


Asp Thr Tyr Glu Pro Leu Gly Ser Ser His Leu Thr Pro Lys Leu Gln 
            740                 745                 750         


Gly Arg Ile Ser Glu Glu Tyr Thr Gln Thr Ala Leu 
        755                 760                 


<210>  55
<211>  764
<212>  PRT
<213>  Ovis aries

<400>  55

Met Arg Pro Thr Pro Leu Leu Arg Leu Ala Leu Leu Leu Val Leu Pro 
1               5                   10                  15      


Ser Ser Leu Trp Gly Glu Arg Cys Pro Ser Pro Pro Cys Glu Cys Arg 
            20                  25                  30          


Gln Glu Asp Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Phe Ile Glu Thr His Leu 
    50                  55                  60                  


Lys Thr Ile Pro Ser Arg Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Ala Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Ser Leu Thr Tyr Ile Asp Ser Gly Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Arg Val Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Ile Tyr Ser Thr Asp Val Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Val Pro Ala Asn Ala Phe Gln Gly Leu Ser 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Ile 
            180                 185                 190         


Gln Gly His Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Gln Asp Ala Phe Ala Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Thr Leu Leu Asp Ile Ser Tyr Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Asn Ile Arg Gly Ile Leu Gln Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Ile Trp Gly Leu Arg Gln Arg Lys Ser Ala Ser Ala Leu Asn Gly 
305                 310                 315                 320 


Pro Phe Tyr Gln Glu Tyr Glu Glu Asp Leu Gly Asp Gly Ser Ala Gly 
                325                 330                 335     


Tyr Lys Glu Asn Ser Lys Phe Gln Asp Thr His Ser Asn Ser His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Asp Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Asn His 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Gly Ser Glu Glu Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Val Ile Leu Leu Thr Ser His Tyr Lys Leu Thr Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Leu Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr Gln Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met His 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Trp His Ala Tyr Val Ile Met Leu Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Ile Leu Val Leu Leu Leu Asn Ile Ile 
            580                 585                 590         


Ala Phe Ile Ile Val Cys Ala Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro His Tyr Asn Pro Gly Asp Lys Asp Thr Arg Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Met Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Leu Met Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Thr Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Met Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Ser Ser Lys Asn Ser Thr Gly Ile Arg 
705                 710                 715                 720 


Val Gln Lys Val Pro Pro Asp Val Arg Gln Ser Leu Pro Asn Val Gln 
                725                 730                 735     


Asp Asp Tyr Glu Leu Leu Gly Asn Ser His Leu Thr Pro Lys Gln Gln 
            740                 745                 750         


Asp Gln Thr Ser Lys Glu Tyr Lys Gln Thr Val Leu 
        755                 760                 


<210>  56
<211>  764
<212>  PRT
<213>  Equus caballus

<400>  56

Met Arg Pro Thr Pro Leu Leu Gln Leu Val Leu Leu Leu Ala Leu Pro 
1               5                   10                  15      


Arg Ser Leu Gly Gly Lys Gly Cys Pro Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Asp Asp Phe Arg Val Thr Cys Lys Asp Ile His His Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Phe Thr Glu Thr His Leu 
    50                  55                  60                  


Lys Thr Ile Pro Ser Arg Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Thr Ser Leu Gln Arg Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Met Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Ser Leu Thr Tyr Ile Glu Pro Gly Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Arg Val Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Val Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Ala Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Val Lys Leu Tyr Asn Asn Gly Phe Thr Ser Ile 
            180                 185                 190         


Gln Gly His Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Thr Leu Leu Asp Val Ser Tyr Thr Thr Leu Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Ile Arg Asn Leu Arg Gln Lys Lys Ser Val Asn Ala Leu Asn Gly 
305                 310                 315                 320 


Pro Phe Tyr Gln Glu Tyr Glu Glu Gly Leu Gly Asp Ser Ser Ala Gly 
                325                 330                 335     


Tyr Lys Glu Asn Ser Lys Phe Gln Asp Ile His Ser Asn Ser His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser Ser 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Gly Asn Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Val Ile Leu Leu Thr Ser His Tyr Lys Leu Thr Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Tyr Ile Ile Met Val Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Ile Leu Val Leu Leu Leu Asn Ile Val 
            580                 585                 590         


Ala Phe Ile Ile Val Cys Ser Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Met Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Leu Met Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Thr Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Ser Gln Lys Asn Ser Thr Gly Leu Gln 
705                 710                 715                 720 


Val Gln Lys Val Thr Gln Asp Met Arg Gln Asn Leu Pro Asn Ile Gln 
                725                 730                 735     


Asp Ala Tyr Glu Leu Leu Glu Asn Ser His Leu Thr Pro Asn Lys Arg 
            740                 745                 750         


Ser Gln Ile Ser Lys Val Tyr Lys Gln Thr Val Leu 
        755                 760                 


<210>  57
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Leu Leu Leu Val Ser Leu Leu Ala Phe Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gly Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys 
            20                  25                  30          


Gln Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala 
        35                  40                  45              


Ile Glu Leu Arg Phe Val Leu Thr Lys Leu Arg Val Ile Gln Lys Gly 
    50                  55                  60                  


Ala Phe Ser Gly Phe Gly Asp Leu Glu Lys Ile Glu Ile Ser Gln Asn 
65                  70                  75                  80  


Asp Val Leu Glu Val Ile Glu Ala Asp Val Phe Ser Asn Leu Pro Lys 
                85                  90                  95      


Leu His Glu Ile Arg Ile Glu Lys Ala Asn Asn Leu Leu Tyr Ile Asn 
            100                 105                 110         


Pro Glu Ala Phe Gln Asn Leu Pro Asn Leu Gln Tyr Leu Leu Ile Ser 
        115                 120                 125             


Asn Thr Gly Ile Lys His Leu Pro Asp Val His Lys Ile His Ser Leu 
    130                 135                 140                 


Gln Lys Val Leu Leu Asp Ile Gln Asp Asn Ile Asn Ile His Thr Ile 
145                 150                 155                 160 


Glu Arg Asn Ser Phe Val Gly Leu Ser Phe Glu Ser Val Ile Leu Trp 
                165                 170                 175     


Leu Asn Lys Asn Gly Ile Gln Glu Ile His Asn Cys Ala Phe Asn Gly 
            180                 185                 190         


Thr Gln Leu Asp Glu Leu Asn Leu Ser Asp Asn Asn Asn Leu Glu Glu 
        195                 200                 205             


Leu Pro Asn Asp Val Phe His Gly Ala Ser Gly Pro Val Ile Leu Asp 
    210                 215                 220                 


Ile Ser Arg Thr Arg Ile His Ser Leu Pro Ser Tyr Gly Leu Glu Asn 
225                 230                 235                 240 


Leu Lys Lys Leu Arg Ala Arg Ser Thr Tyr Asn Leu Lys Lys Leu Pro 
                245                 250                 255     


Thr Leu Glu Lys Leu Val Ala Leu Met Glu Ala Ser Leu Thr Tyr Pro 
            260                 265                 270         


Ser His Cys Cys Ala Phe Ala Asn Trp Arg Arg Gln Ile Ser Glu Leu 
        275                 280                 285             


His Pro Ile Cys Asn Lys Ser Ile Leu Arg Gln Glu Val Asp Tyr Met 
    290                 295                 300                 


Thr Gln Ala Arg Gly Gln Arg Ser Ser Leu Ala Glu Asp Asn Glu Ser 
305                 310                 315                 320 


Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr Thr Glu Phe Asp Tyr Asp 
                325                 330                 335     


Leu Cys Asn Glu Val Val Asp Val Thr Cys Ser Pro Lys Pro Asp Ala 
            340                 345                 350         


Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Asn Ile Leu Arg Val Leu 
        355                 360                 365             


Ile Trp Phe Ile Ser Ile Leu Ala Ile Thr Gly Asn Ile Ile Val Leu 
    370                 375                 380                 


Val Ile Leu Thr Thr Ser Gln Tyr Lys Leu Thr Val Pro Arg Phe Leu 
385                 390                 395                 400 


Met Cys Asn Leu Ala Phe Ala Asp Leu Cys Ile Gly Ile Tyr Leu Leu 
                405                 410                 415     


Leu Ile Ala Ser Val Asp Ile His Thr Lys Ser Gln Tyr His Asn Tyr 
            420                 425                 430         


Ala Ile Asp Trp Gln Thr Gly Ala Gly Cys Asp Ala Ala Gly Phe Phe 
        435                 440                 445             


Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Ala Ile Thr 
    450                 455                 460                 


Leu Glu Arg Trp His Thr Ile Thr His Ala Met Gln Leu Asp Cys Lys 
465                 470                 475                 480 


Val Gln Leu Arg His Ala Ala Ser Val Met Val Met Gly Trp Ile Phe 
                485                 490                 495     


Ala Phe Ala Ala Ala Leu Phe Pro Ile Phe Gly Ile Ser Ser Tyr Met 
            500                 505                 510         


Lys Val Ser Ile Cys Leu Pro Met Asp Ile Asp Ser Pro Leu Ser Gln 
        515                 520                 525             


Leu Tyr Val Met Ser Leu Leu Val Leu Asn Val Leu Ala Phe Val Val 
    530                 535                 540                 


Ile Cys Gly Cys Tyr Ile His Ile Tyr Leu Thr Val Arg Asn Pro Asn 
545                 550                 555                 560 


Ile Val Ser Ser Ser Ser Asp Thr Arg Ile Ala Lys Arg Met Ala Met 
                565                 570                 575     


Leu Ile Phe Thr Asp Phe Leu Cys Met Ala Pro Ile Ser Phe Phe Ala 
            580                 585                 590         


Ile Ser Ala Ser Leu Lys Val Pro Leu Ile Thr Val Ser Lys Ala Lys 
        595                 600                 605             


Ile Leu Leu Val Leu Phe His Pro Ile Asn Ser Cys Ala Asn Pro Phe 
    610                 615                 620                 


Leu Tyr Ala Ile Phe Thr Lys Asn Phe Arg Arg Asp Phe Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Lys Cys Gly Cys Tyr Glu Met Gln Ala Gln Ile Tyr Arg Thr 
                645                 650                 655     


Glu Thr Ser Ser Thr Val His Asn Thr His Pro Arg Asn Gly His Cys 
            660                 665                 670         


Ser Ser Ala Pro Arg Val Thr Asn Gly Ser Thr Tyr Ile Leu Val Pro 
        675                 680                 685             


Leu Ser His Leu Ala Gln Asn 
    690                 695 


<210>  58
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Lys Gln Arg Phe Ser Ala Leu Gln Leu Leu Lys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gln Pro Pro Leu Pro Arg Ala Leu Arg Glu Ala Leu Cys Pro Glu 
            20                  25                  30          


Pro Cys Asn Cys Val Pro Asp Gly Ala Leu Arg Cys Pro Gly Pro Thr 
        35                  40                  45              


Ala Gly Leu Thr Arg Leu Ser Leu Ala Tyr Leu Pro Val Lys Val Ile 
    50                  55                  60                  


Pro Ser Gln Ala Phe Arg Gly Leu Asn Glu Val Ile Lys Ile Glu Ile 
65                  70                  75                  80  


Ser Gln Ile Asp Ser Leu Glu Arg Ile Glu Ala Asn Ala Phe Asp Asn 
                85                  90                  95      


Leu Leu Asn Leu Ser Glu Ile Leu Ile Gln Asn Thr Lys Asn Leu Arg 
            100                 105                 110         


Tyr Ile Glu Pro Gly Ala Phe Ile Asn Leu Pro Arg Leu Lys Tyr Leu 
        115                 120                 125             


Ser Ile Cys Asn Thr Gly Ile Arg Lys Phe Pro Asp Val Thr Lys Val 
    130                 135                 140                 


Phe Ser Ser Glu Ser Asn Phe Ile Leu Glu Ile Cys Asp Asn Leu His 
145                 150                 155                 160 


Ile Thr Thr Ile Pro Gly Asn Ala Phe Gln Gly Met Asn Asn Glu Ser 
                165                 170                 175     


Val Thr Leu Lys Leu Tyr Gly Asn Gly Phe Glu Glu Val Gln Ser His 
            180                 185                 190         


Ala Phe Asn Gly Thr Thr Leu Thr Ser Leu Glu Leu Lys Glu Asn Val 
        195                 200                 205             


His Leu Glu Lys Met His Asn Gly Ala Phe Arg Gly Ala Thr Gly Pro 
    210                 215                 220                 


Lys Thr Leu Asp Ile Ser Ser Thr Lys Leu Gln Ala Leu Pro Ser Tyr 
225                 230                 235                 240 


Gly Leu Glu Ser Ile Gln Arg Leu Ile Ala Thr Ser Ser Tyr Ser Leu 
                245                 250                 255     


Lys Lys Leu Pro Ser Arg Glu Thr Phe Val Asn Leu Leu Glu Ala Thr 
            260                 265                 270         


Leu Thr Tyr Pro Ser His Cys Cys Ala Phe Arg Asn Leu Pro Thr Lys 
        275                 280                 285             


Glu Gln Asn Phe Ser His Ser Ile Ser Glu Asn Phe Ser Lys Gln Cys 
    290                 295                 300                 


Glu Ser Thr Val Arg Lys Val Asn Asn Lys Thr Leu Tyr Ser Ser Met 
305                 310                 315                 320 


Leu Ala Glu Ser Glu Leu Ser Gly Trp Asp Tyr Glu Tyr Gly Phe Cys 
                325                 330                 335     


Leu Pro Lys Thr Pro Arg Cys Ala Pro Glu Pro Asp Ala Phe Asn Pro 
            340                 345                 350         


Cys Glu Asp Ile Met Gly Tyr Asp Phe Leu Arg Val Leu Ile Trp Leu 
        355                 360                 365             


Ile Asn Ile Leu Ala Ile Met Gly Asn Met Thr Val Leu Phe Val Leu 
    370                 375                 380                 


Leu Thr Ser Arg Tyr Lys Leu Thr Val Pro Arg Phe Leu Met Cys Asn 
385                 390                 395                 400 


Leu Ser Phe Ala Asp Phe Cys Met Gly Leu Tyr Leu Leu Leu Ile Ala 
                405                 410                 415     


Ser Val Asp Ser Gln Thr Lys Gly Gln Tyr Tyr Asn His Ala Ile Asp 
            420                 425                 430         


Trp Gln Thr Gly Ser Gly Cys Ser Thr Ala Gly Phe Phe Thr Val Phe 
        435                 440                 445             


Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Val Ile Thr Leu Glu Arg 
    450                 455                 460                 


Trp His Thr Ile Thr Tyr Ala Ile His Leu Asp Gln Lys Leu Arg Leu 
465                 470                 475                 480 


Arg His Ala Ile Leu Ile Met Leu Gly Gly Trp Leu Phe Ser Ser Leu 
                485                 490                 495     


Ile Ala Met Leu Pro Leu Val Gly Val Ser Asn Tyr Met Lys Val Ser 
            500                 505                 510         


Ile Cys Phe Pro Met Asp Val Glu Thr Thr Leu Ser Gln Val Tyr Ile 
        515                 520                 525             


Leu Thr Ile Leu Ile Leu Asn Val Val Ala Phe Phe Ile Ile Cys Ala 
    530                 535                 540                 


Cys Tyr Ile Lys Ile Tyr Phe Ala Val Arg Asn Pro Glu Leu Met Ala 
545                 550                 555                 560 


Thr Asn Lys Asp Thr Lys Ile Ala Lys Lys Met Ala Ile Leu Ile Phe 
                565                 570                 575     


Thr Asp Phe Thr Cys Met Ala Pro Ile Ser Phe Phe Ala Ile Ser Ala 
            580                 585                 590         


Ala Phe Lys Val Pro Leu Ile Thr Val Thr Asn Ser Lys Val Leu Leu 
        595                 600                 605             


Val Leu Phe Tyr Pro Ile Asn Ser Cys Ala Asn Pro Phe Leu Tyr Ala 
    610                 615                 620                 


Ile Phe Thr Lys Thr Phe Gln Arg Asp Phe Phe Leu Leu Leu Ser Lys 
625                 630                 635                 640 


Phe Gly Cys Cys Lys Arg Arg Ala Glu Leu Tyr Arg Arg Lys Asp Phe 
                645                 650                 655     


Ser Ala Tyr Thr Ser Asn Cys Lys Asn Gly Phe Thr Gly Ser Asn Lys 
            660                 665                 670         


Pro Ser Gln Ser Thr Leu Lys Leu Ser Thr Leu His Cys Gln Gly Thr 
        675                 680                 685             


Ala Leu Leu Asp Lys Thr Arg Tyr Thr Glu Cys 
    690                 695                 


<210>  59
<211>  2292
<212>  DNA
<213>  Homo sapiens

<400>  59
atgaggccgg cggacttgct gcagctggtg ctgctgctcg acctgcccag ggacctgggc       60

ggaatggggt gttcgtctcc accctgcgag tgccatcagg aggaggactt cagagtcacc      120

tgcaaggata ttcaacgcat ccccagctta ccgcccagta cgcagactct gaagcttatt      180

gagactcacc tgagaactat tccaagtcat gcattttcta atctgcccaa tatttccaga      240

atctacgtat ctatagatgt gactctgcag cagctggaat cacactcctt ctacaatttg      300

agtaaagtga ctcacataga aattcggaat accaggaact taacttacat agaccctgat      360

gccctcaaag agctccccct cctaaagttc cttggcattt tcaacactgg acttaaaatg      420

ttccctgacc tgaccaaagt ttattccact gatatattct ttatacttga aattacagac      480

aacccttaca tgacgtcaat ccctgtgaat gcttttcagg gactatgcaa tgaaaccttg      540

acactgaagc tgtacaacaa cggctttact tcagtccaag gatatgcttt caatgggaca      600

aagctggatg ctgtttacct aaacaagaat aaatacctga cagttattga caaagatgca      660

tttggaggag tatacagtgg accaagcttg ctggacgtgt ctcaaaccag tgtcactgcc      720

cttccatcca aaggcctgga gcacctgaag gaactgatag caagaaacac ctggactctt      780

aacatcatcc cagttgagga ggagaacccg gacttctgga accgcgaggc agccgaggcc      840

ctgggtgccg ccaagaagct gcagcctgca cagacagccg ccaagaacct catcatcttc      900

ctgggcgatg ggatgggggt gtctacggtg acagctgcca ggatcctaaa agggcagaag      960

aaggacaaac tggggcctga gatacccctg gccatggacc gcttcccata tgtggctctg     1020

tccaagacat acaatgtaga caaacatgtg ccagacagtg gagccacagc cacggcctac     1080

ctgtgcgggg tcaagggcaa cttccagacc attggcttga gtgcagccgc ccgctttaac     1140

cagtgcaaca cgacacgcgg caacgaggtc atctccgtga tgaatcgggc caagaaagca     1200

gggaagtcag tgggagtggt aaccaccaca cgagtgcagc acgcctcgcc agccggcacc     1260

tacgcccaca cggtgaaccg caactggtac tcggacgccg acgtgcctgc ctcggcccgc     1320

caggaggggt gccaggacat cgctacgcag ctcatctcca acatggacat tgacgtgatc     1380

ctaggtggag gccgaaagta catgtttcgc atgggaaccc cagaccctga gtacccagat     1440

gactacagcc aaggtgggac caggctggac gggaagaatc tggtgcagga atggctggcg     1500

aagcgccagg gtgcccggta tgtgtggaac cgcactgagc tcatgcaggc ttccctggac     1560

ccgtctgtga cccatctcat gggtctcttt gagcctggag acatgaaata cgagatccac     1620

cgagactcca cactggaccc ctccctgatg gagatgacag aggctgccct gcgcctgctg     1680

agcaggaacc cccgcggctt cttcctcttc gtggagggtg gtcgcatcga ccatggtcat     1740

catgaaagca gggcttaccg ggcactgact gagacgatca tgttcgacga cgccattgag     1800

agggcgggcc agctcaccag cgaggaggac acgctgagcc tcgtcactgc cgaccactcc     1860

cacgtcttct ccttcggagg ctaccccctg cgagggagct ccatcttcgg gctggcccct     1920

ggcaaggccc gggacaggaa ggcctacacg gtcctcctat acggaaacgg tccaggctat     1980

gtgctcaagg acggcgcccg gccggatgtt accgagagcg agagcgggag ccccgagtat     2040

cggcagcagt cagcagtgcc cctggacgaa gagacccacg caggcgagga cgtggcggtg     2100

ttcgcgcgcg gcccgcaggc gcacctggtt cacggcgtgc aggagcagac cttcatagcg     2160

cacgtcatgg ccttcgccgc ctgcctggag ccctacaccg cctgcgacct ggcgcccccc     2220

gccggcacca ccgacgccgc gcacccgggt tactctagag tcggggcggc cggccgcttc     2280

gagcagacat ga                                                         2292


<210>  60
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Asp Leu Pro 
1               5                   10                  15      


Arg Asp Leu Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Asn Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe 
            260                 265                 270         


Trp Asn Arg Glu Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln 
        275                 280                 285             


Pro Ala Gln Thr Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly 
    290                 295                 300                 


Met Gly Val Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys 
305                 310                 315                 320 


Lys Asp Lys Leu Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe Pro 
                325                 330                 335     


Tyr Val Ala Leu Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp 
            340                 345                 350         


Ser Gly Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe 
        355                 360                 365             


Gln Thr Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr 
    370                 375                 380                 


Thr Arg Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala 
385                 390                 395                 400 


Gly Lys Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser 
                405                 410                 415     


Pro Ala Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp 
            420                 425                 430         


Ala Asp Val Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala 
        435                 440                 445             


Thr Gln Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly 
    450                 455                 460                 


Arg Lys Tyr Met Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp 
465                 470                 475                 480 


Asp Tyr Ser Gln Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln 
                485                 490                 495     


Glu Trp Leu Ala Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr 
            500                 505                 510         


Glu Leu Met Gln Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly 
        515                 520                 525             


Leu Phe Glu Pro Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr 
    530                 535                 540                 


Leu Asp Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu 
545                 550                 555                 560 


Ser Arg Asn Pro Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile 
                565                 570                 575     


Asp His Gly His His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr 
            580                 585                 590         


Ile Met Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu 
        595                 600                 605             


Glu Asp Thr Leu Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser 
    610                 615                 620                 


Phe Gly Gly Tyr Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro 
625                 630                 635                 640 


Gly Lys Ala Arg Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn 
                645                 650                 655     


Gly Pro Gly Tyr Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu 
            660                 665                 670         


Ser Glu Ser Gly Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu 
        675                 680                 685             


Asp Glu Glu Thr His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly 
    690                 695                 700                 


Pro Gln Ala His Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala 
705                 710                 715                 720 


His Val Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp 
                725                 730                 735     


Leu Ala Pro Pro Ala Gly Thr Thr Asp Ala Ala His Pro Gly Tyr Ser 
            740                 745                 750         


Arg Val Gly Ala Ala Gly Arg Phe Glu Gln Thr 
        755                 760             


<210>  61
<211>  2295
<212>  DNA
<213>  Sus scrofa

<400>  61
atgagtctga cgcccctgtt gcagctggcg ctgcttctcg ccctgcccag gagcctcagg       60

gggaaagggt gtccgtctcc gccctgcgaa tgccaccagg aggacgactt cagagtcacc      120

tgcaaggata tccacagcat ccccccctta ccacccaata ctcagacact aaagtttata      180

gagactcatc tgaaaaccat ccccagtcgt gcattttcaa atctgcccaa tatttccagg      240

atctacctgt caatagatgc aactctacag cagctggaat cacagtcctt ctacaatttg      300

agcaaaatga ctcacataga gattcggaat accagaagct taacgtacat aaaccctggt      360

gccctaaaag atctccccct tctaaagttc cttggcattt tcaacactgg acttagaata      420

ttcccagacc tgaccaaagt gtattccact gatgtattct tcatacttga aattacagac      480

aacccttaca tgacatcaat ccctgcgaat gcttttcagg gcctgtgcaa cgaaaccttg      540

acactgaaac tatacaacaa tggctttact tcagtccaag gacatgcttt caatgggaca      600

aagctggatg ctgtttacct gaacaagaat aaatacctga cagttattga caaagatgca      660

tttggaggag ttttcagtgg accaaccttg ctggatgtct cttataccag tgttactgcc      720

ctgccaccca aaggcctgga acacctgaag gaactgatag caagaaatac ttggactcta      780

aagaaacttc cactgtcctt gagtttcctt cacctcacac gagctgacct ttcttatcca      840

agccactgct gtgcttttaa gaatcagaag aagatcagag gaatccttga gtctttaatg      900

tgtaatgaga gcagtattcg gagcctgcgt cagagaaaat ctgtgaatgc tgtaaatggt      960

cccttttacc aagaatatga agaggatctg ggcgacagca gtgttgggaa taaggaaaac     1020

tccaagttcc aggataccca tagcaactcc cattactacg tcttctttga agaacaagag     1080

gatgagatca ttggttttgg ccaagagctc aaaaaccccc aggaagagac cctccaggcc     1140

tttgacagcc attacgacta caccgtgtgt gggggcagtg aagacatggt gtgcaccccc     1200

aagtcagatg agttcaaccc ctgtgaagac ataatgggct acaggttcct gagaatcgtg     1260

gtgtggttcg ttagcctgct ggctctcctg ggcaatgtct ttgtcctggt catcctcctc     1320

acgagccact acaaactgac ggtcccacgc tttctcatgt gcaacttggc ctttgcagat     1380

ttctgcatgg ggatgtatct gctcctcatt gcctcggtgg acctctacac tcagtctgag     1440

tactacaacc atgccatcga ctggcagaca ggtcccgggt gcaacacggc tggtttcttc     1500

accgtctttg ccagcgagct gtcagtgtac acactaacag tcatcactct ggagcgctgg     1560

tatgccatca ccttcgccat gcgcctggat cgcaagatcc gcctcaggca cgcctacgcc     1620

atcatggctg gcggctgggt ttgctgcttc ctgctcgccc tgctgccttt ggtggggata     1680

agcagctatg ctaaggtcag catctgcctg cccatggaca ctgagactcc tcttgccctg     1740

gcgtatatta tccttgttct gctgctcaac atagttgcct ttaccatcgt ctgctcctgt     1800

tacgtgaaga tctacatcac agtccgaaat ccccagtata acccgggaga caaagacact     1860

aaaattgcca aaaggatggc tgtgttgatc ttcactgact tcatgtgcat ggccccgatc     1920

tccttttacg ccctctcagc acttatgaac aagcctctca tcactgtcac caactccaaa     1980

atcttgctcg ttctcttcta cccacttaac tcctgtgcca acccgttcct ctatgccatt     2040

ttcaccaaag ccttccagag ggatgtgttt atcctgctca gcaagttcgg cttctgtaaa     2100

cgccaggctc aggcataccg gggtcagaga gtgtctccaa agaacagcac tggtattcag     2160

gtccaaaagg ttacccaaaa catgaggcaa agtctcccca acatgcagga tgactatgaa     2220

ctgcttgaaa actcgcatct aacccacaaa aagcatgacc aaatttcaaa ggagtataag     2280

caaccagttt tgtaa                                                      2295


<210>  62
<211>  764
<212>  PRT
<213>  Sus scrofa

<400>  62

Met Ser Leu Thr Pro Leu Leu Gln Leu Ala Leu Leu Leu Ala Leu Pro 
1               5                   10                  15      


Arg Ser Leu Arg Gly Lys Gly Cys Pro Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Asp Asp Phe Arg Val Thr Cys Lys Asp Ile His Ser Ile Pro 
        35                  40                  45              


Pro Leu Pro Pro Asn Thr Gln Thr Leu Lys Phe Ile Glu Thr His Leu 
    50                  55                  60                  


Lys Thr Ile Pro Ser Arg Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Ala Thr Leu Gln Gln Leu Glu Ser Gln Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Met Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Ser Leu Thr Tyr Ile Asn Pro Gly Ala Leu Lys Asp Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Arg Ile Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Val Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Ala Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly His Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Phe Ser Gly Pro Thr Leu Leu Asp Val Ser Tyr Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Pro Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Ile Arg Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Val Asn Gly 
305                 310                 315                 320 


Pro Phe Tyr Gln Glu Tyr Glu Glu Asp Leu Gly Asp Ser Ser Val Gly 
                325                 330                 335     


Asn Lys Glu Asn Ser Lys Phe Gln Asp Thr His Ser Asn Ser His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Gly Ser Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Arg Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Val Ile Leu Leu Thr Ser His Tyr Lys Leu Thr Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr Gln Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Tyr Ala Ile Met Ala Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Ile Leu Val Leu Leu Leu Asn Ile Val 
            580                 585                 590         


Ala Phe Thr Ile Val Cys Ser Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Met Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Leu Met Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Thr Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Phe Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Ser Pro Lys Asn Ser Thr Gly Ile Gln 
705                 710                 715                 720 


Val Gln Lys Val Thr Gln Asn Met Arg Gln Ser Leu Pro Asn Met Gln 
                725                 730                 735     


Asp Asp Tyr Glu Leu Leu Glu Asn Ser His Leu Thr His Lys Lys His 
            740                 745                 750         


Asp Gln Ile Ser Lys Glu Tyr Lys Gln Pro Val Leu 
        755                 760                 


<210>  63
<211>  2295
<212>  DNA
<213>  Mus musculus

<400>  63
atgaggccag ggtccctgct gctgcttgtt ctgctgctcg ccctgtccag gagcctgcgg       60

ggcaaagagt gtgcgtctcc accctgtgag tgtcaccagg aggacgactt cagagtcacc      120

tgcaaggagc tccaccgaat ccccagcctg ccgcccagca cccagactct gaagctcatc      180

gagactcatc tgaagaccat acccagtctt gcattttcga gtctgcccaa tatttccagg      240

atctatttat ctatagatgc aactctgcag cggctggaac cacattcttt ctacaatttg      300

agtaaaatga ctcacataga aatccggaac accagaagct taacctatat agaccctgat      360

gccttgacag agctcccctt gctcaagttt cttggcattt tcaatactgg acttagaata      420

ttccctgact tgaccaaaat ttattccacg gacatattct ttatacttga aatcacagac      480

aacccttaca tgacttcggt ccctgaaaac gcattccagg gcctatgcaa tgaaaccttg      540

accctgaaac tgtacaacaa tggatttact tcagtccaag gacatgcttt caatggaaca      600

aagctggatg ctgtttacct aaacaagaat aaatacctga cagctataga caacgatgcc      660

tttggaggag tatacagtgg accaactttg ctagatgtgt cttccaccag cgtcactgcc      720

cttccttcca aaggcctgga gcacctcaaa gaactgatcg caaaagacac ctggactctc      780

aaaaagctcc cgctgtcgtt gagtttcctc cacctcactc gggctgacct ctcttacccg      840

agccactgct gcgcttttaa gaaccagaag aaaatcaggg gaatcctgga gtctttgatg      900

tgtaatgaga gcagtatccg gaaccttcgt caaaggaaat cagtgaacat cttgaggggt      960

cccatctacc aggaatatga agaagatccg ggtgacaaca gtgttgggta caaacaaaac     1020

tccaagttcc aggagagccc aagcaactct cactattacg tcttctttga agaacaagag     1080

gatgaggtcg ttggtttcgg ccaagagctc aaaaatcctc aggaagagac tctccaagcc     1140

ttcgagagcc actatgacta cacggtgtgt ggggacaacg aggacatggt gtgtaccccc     1200

aagtcggacg agtttaaccc ctgtgaagat atcatgggct acaggttcct gagaatcgtg     1260

gtgtggtttg tcagtctgct ggctctcctg ggcaatatct tcgtcctgct cattctgcta     1320

accagccact acaaattgac cgtgccgcgg ttcctcatgt gcaacttggc ctttgcagat     1380

ttctgcatgg gggtatacct gcttctcatt gcctctgtag acctgtacac acactctgag     1440

tactacaacc acgccatcga ctggcagacg ggccctgggt gcaacacggc tggcttcttc     1500

actgttttcg ccagtgagtt atcagtgtac acactgacgg tcatcaccct ggagcgatgg     1560

tacgccatca ccttcgccat gcgcctggat aggaagatcc gcctcaggca cgcgtacacc     1620

atcatggctg ggggctgggt ttcctgcttc cttctcgccc tgctcccgat ggtgggaatc     1680

agcagctatg ccaaggtcag catctgcctg ccaatggaca ccgacacccc tcttgcactc     1740

gcatacattg tcctcgttct gctgctcaat gttgttgcct ttgttgtcgt ctgttcctgc     1800

tatgtgaaga tctacatcac ggtccgaaat ccccagtaca accctcgaga taaagacacc     1860

aagattgcca agaggatggc tgtgttgatc ttcactgact tcatgtgcat ggcgcccatc     1920

tccttctatg cgctgtcggc acttatgaac aagcctctaa tcactgttac taactccaaa     1980

atcttgttgg ttctcttcta ccccctcaac tcctgtgcca atccgtttct ctatgctatt     2040

ttcaccaagg ccttccagag ggacgtgttc atcctgctca gcaagtttgg catctgcaaa     2100

cgccaggccc aggcctatca gggtcagaga gtctgtccca acaatagcac tggtattcag     2160

atccaaaaga ttccccagga cacgaggcag agtctcccca acatgcaaga tacctatgaa     2220

ctgcttggaa actcccagct agctccaaaa ctgcagggac aaatctcaga agagtataag     2280

caaacagcct tgtaa                                                      2295


<210>  64
<211>  764
<212>  PRT
<213>  Mus musculus

<400>  64

Met Arg Pro Gly Ser Leu Leu Leu Leu Val Leu Leu Leu Ala Leu Ser 
1               5                   10                  15      


Arg Ser Leu Arg Gly Lys Glu Cys Ala Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Asp Asp Phe Arg Val Thr Cys Lys Glu Leu His Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Lys Thr Ile Pro Ser Leu Ala Phe Ser Ser Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Ala Thr Leu Gln Arg Leu Glu Pro His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Met Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Ser Leu Thr Tyr Ile Asp Pro Asp Ala Leu Thr Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Arg Ile Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Ile Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Val Pro Glu Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly His Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Ala Ile Asp Asn Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Thr Leu Leu Asp Val Ser Ser Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Lys Asp 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Ile Arg Asn Leu Arg Gln Arg Lys Ser Val Asn Ile Leu Arg Gly 
305                 310                 315                 320 


Pro Ile Tyr Gln Glu Tyr Glu Glu Asp Pro Gly Asp Asn Ser Val Gly 
                325                 330                 335     


Tyr Lys Gln Asn Ser Lys Phe Gln Glu Ser Pro Ser Asn Ser His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Val Val Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Glu Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Asp Asn Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Arg Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Ile Phe Val Leu Leu Ile Leu Leu Thr Ser His Tyr Lys Leu Thr Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Val Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Tyr Thr Ile Met Ala Gly 
    530                 535                 540                 


Gly Trp Val Ser Cys Phe Leu Leu Ala Leu Leu Pro Met Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Asp Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Val Leu Val Leu Leu Leu Asn Val Val 
            580                 585                 590         


Ala Phe Val Val Val Cys Ser Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Arg Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Met Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Leu Met Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Thr Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Gln Gly Gln Arg Val Cys Pro Asn Asn Ser Thr Gly Ile Gln 
705                 710                 715                 720 


Ile Gln Lys Ile Pro Gln Asp Thr Arg Gln Ser Leu Pro Asn Met Gln 
                725                 730                 735     


Asp Thr Tyr Glu Leu Leu Gly Asn Ser Gln Leu Ala Pro Lys Leu Gln 
            740                 745                 750         


Gly Gln Ile Ser Glu Glu Tyr Lys Gln Thr Ala Leu 
        755                 760                 


<210>  65
<211>  2295
<212>  DNA
<213>  Sus scrofa

<400>  65
atgagtctga cgcccctgtt gcagctggcg ctgcttctcg ccctgcccag gagcctcagg       60

gggaaagggt gtccgtctcc gccctgcgaa tgccaccagg aggacgactt cagagtcacc      120

tgcaaggata tccacagcat ccccccctta ccacccaata ctcagacact aaagtttata      180

gagacttgtc tgaaaaccat ccccagtcgt gcattttcaa atctgcccaa tatttccagg      240

atctacctgt caatagatgc aactctacag cagctggaat cacagtcctt ctacaatttg      300

agcaaaatga ctcacataga gattcggaat accccaagct taacgtacat aaaccctggt      360

gccctaaaag atctccccct tctaaagttc cttggcattt tcaacactgg acttagaata      420

ttcccacccc tgaccaaagt gtattccact gaggtattct tcatacttga aattacagac      480

aacccttaca tgacatcaat ccctcggaat gcttttcagg gcctgtgcaa cgaaaccttg      540

acactgaaac tatacaacaa tggctttact tcagtccaag gacatgcttt caatgggaca      600

aagctggatg ctgtttacct gaacaagaat aaatacctga cagttattga caaagatgca      660

tttggaggag ttttcagtgg accaaccttg ctggatgtct cttataccag tgttactgcc      720

ctgccaccca aaggcctgga acacctgaag gaactgagag caagaaatac ttggactcta      780

aagaaacttc cactgtcctt gagtttcctt cacctcacac gagctgacct ttcttatcca      840

agccactgct gtgcttttaa gaatcagaag aagatcagag gaatccttga gtctttaatg      900

tgtaatgaga gcagtattcg gagcctgcgt cagagaaaat ctgtgaatgc tgtaaatggt      960

cccttttacc aagaatatga agaggatctg ggcgacagca gtgttgggaa taaggaaaac     1020

tccaagttcc aggataccca tagcaactcc cattactacg tcttctttga agaacaagag     1080

gatgagatca ttggttttgg ccaagagctc aaaaaccccc aggaagagac cctccaggcc     1140

tttgacagcc attacgacta caccgtgtgt gggggcagtg aagacatggt gtgcaccccc     1200

aagtcagatg agttcaaccc ctgtgaagac ataatgggct acaggttcct gagaatcgtg     1260

gtgtggttcg ttagcctgct ggctctcctg ggcaatgtct ttgtcctggt catcctcctc     1320

acgagccact acaaactgac ggtcccacgc tttctcatgt gcaacttggc ctttgcagat     1380

ttctgcatgg ggatgtatct gctcctcatt gcctcggtgg acctctacac tcagtctgag     1440

tactacaacc atgccatcga ctggcagaca ggtcccgggt gcaacacggc tggtttcttc     1500

accgtctttg ccagcgagct gtcagtgtac acactaacag tcatcactct ggagcgctgg     1560

tatgccatca ccttcgccat gcgcctggat cgcaagatcc gcctcaggca cgcctacgcc     1620

atcatggctg gcggctgggt ttgctgcttc ctgctcgccc tgctgccttt ggtggggata     1680

agcagctatg ctaaggtcag catctgcctg cccatggaca ctgagactcc tcttgccctg     1740

gcgtatatta tccttgttct gctgctcaac atagttgcct ttaccatcgt ctgctcctgt     1800

tacgtgaaga tctacatcac agtccgaaat ccccagtata acccgggaga caaagacact     1860

aaaattgcca aaaggatggc tgtgttgatc ttcactgact tcatgtgcat ggccccgatc     1920

tccttttacg ccctctcagc acttatgaac aagcctctca tcactgtcac caactccaaa     1980

atcttgctcg ttctcttcta cccacttaac tcctgtgcca acccgttcct ctatgccatt     2040

ttcaccaaag ccttccagag ggatgtgttt atcctgctca gcaagttcgg cttctgtaaa     2100

cgccaggctc aggcataccg gggtcagaga gtgtctccaa agaacagcac tggtattcag     2160

gtccaaaagg ttacccaaaa catgaggcaa agtctcccca acatgcagga tgactatgaa     2220

ctgcttgaaa actcgcatct aacccacaaa aagcatgacc aaatttcaaa ggagtataag     2280

caaccagttt tgtaa                                                      2295


<210>  66
<211>  764
<212>  PRT
<213>  Sus scrofa

<400>  66

Met Ser Leu Thr Pro Leu Leu Gln Leu Ala Leu Leu Leu Ala Leu Pro 
1               5                   10                  15      


Arg Ser Leu Arg Gly Lys Gly Cys Pro Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Asp Asp Phe Arg Val Thr Cys Lys Asp Ile His Ser Ile Pro 
        35                  40                  45              


Pro Leu Pro Pro Asn Thr Gln Thr Leu Lys Phe Ile Glu Thr Cys Leu 
    50                  55                  60                  


Lys Thr Ile Pro Ser Arg Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Ala Thr Leu Gln Gln Leu Glu Ser Gln Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Met Thr His Ile Glu Ile Arg Asn Thr Pro 
            100                 105                 110         


Ser Leu Thr Tyr Ile Asn Pro Gly Ala Leu Lys Asp Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Arg Ile Phe Pro Pro Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Glu Val Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Arg Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly His Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Phe Ser Gly Pro Thr Leu Leu Asp Val Ser Tyr Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Pro Lys Gly Leu Glu His Leu Lys Glu Leu Arg Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Ile Arg Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Val Asn Gly 
305                 310                 315                 320 


Pro Phe Tyr Gln Glu Tyr Glu Glu Asp Leu Gly Asp Ser Ser Val Gly 
                325                 330                 335     


Asn Lys Glu Asn Ser Lys Phe Gln Asp Thr His Ser Asn Ser His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Gly Ser Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Arg Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Val Ile Leu Leu Thr Ser His Tyr Lys Leu Thr Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr Gln Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Tyr Ala Ile Met Ala Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Ile Leu Val Leu Leu Leu Asn Ile Val 
            580                 585                 590         


Ala Phe Thr Ile Val Cys Ser Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Met Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Leu Met Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Thr Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Phe Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Ser Pro Lys Asn Ser Thr Gly Ile Gln 
705                 710                 715                 720 


Val Gln Lys Val Thr Gln Asn Met Arg Gln Ser Leu Pro Asn Met Gln 
                725                 730                 735     


Asp Asp Tyr Glu Leu Leu Glu Asn Ser His Leu Thr His Lys Lys His 
            740                 745                 750         


Asp Gln Ile Ser Lys Glu Tyr Lys Gln Pro Val Leu 
        755                 760                 


<210>  67
<211>  2295
<212>  DNA
<213>  Mus musculus

<400>  67
atgaggccag ggtccctgct gctgcttgtt ctgctgctcg ccctgtccag gagcctgcgg       60

ggcaaagagt gtgcgtctcc accctgtgag tgtcaccagg aggacgactt cagagtcacc      120

tgcaaggagc tccaccgaat ccccagcctg ccgcccagca cccagactct gaagctcatc      180

gagacttgtc tgaagaccat acccagtctt gcattttcga gtctgcccaa tatttccagg      240

atctatttat ctatagatgc aactctgcag cggctggaac cacattcttt ctacaatttg      300

agtaaaatga ctcacataga aatccggaac accccaagct taacctatat agaccctgat      360

gccttgacag agctcccctt gctcaagttt cttggcattt tcaatactgg acttagaata      420

ttccctccct tgaccaaaat ttattccacg gagatattct ttatacttga aatcacagac      480

aacccttaca tgacttcggt ccctcgaaac gcattccagg gcctatgcaa tgaaaccttg      540

accctgaaac tgtacaacaa tggatttact tcagtccaag gacatgcttt caatggaaca      600

aagctggatg ctgtttacct aaacaagaat aaatacctga cagctataga caacgatgcc      660

tttggaggag tatacagtgg accaactttg ctagatgtgt cttccaccag cgtcactgcc      720

cttccttcca aaggcctgga gcacctcaaa gaactgcgcg caaaagacac ctggactctc      780

aaaaagctcc cgctgtcgtt gagtttcctc cacctcactc gggctgacct ctcttacccg      840

agccactgct gcgcttttaa gaaccagaag aaaatcaggg gaatcctgga gtctttgatg      900

tgtaatgaga gcagtatccg gaaccttcgt caaaggaaat cagtgaacat cttgaggggt      960

cccatctacc aggaatatga agaagatccg ggtgacaaca gtgttgggta caaacaaaac     1020

tccaagttcc aggagagccc aagcaactct cactattacg tcttctttga agaacaagag     1080

gatgaggtcg ttggtttcgg ccaagagctc aaaaatcctc aggaagagac tctccaagcc     1140

ttcgagagcc actatgacta cacggtgtgt ggggacaacg aggacatggt gtgtaccccc     1200

aagtcggacg agtttaaccc ctgtgaagat atcatgggct acaggttcct gagaatcgtg     1260

gtgtggtttg tcagtctgct ggctctcctg ggcaatatct tcgtcctgct cattctgcta     1320

accagccact acaaattgac cgtgccgcgg ttcctcatgt gcaacttggc ctttgcagat     1380

ttctgcatgg gggtatacct gcttctcatt gcctctgtag acctgtacac acactctgag     1440

tactacaacc acgccatcga ctggcagacg ggccctgggt gcaacacggc tggcttcttc     1500

actgttttcg ccagtgagtt atcagtgtac acactgacgg tcatcaccct ggagcgatgg     1560

tacgccatca ccttcgccat gcgcctggat aggaagatcc gcctcaggca cgcgtacacc     1620

atcatggctg ggggctgggt ttcctgcttc cttctcgccc tgctcccgat ggtgggaatc     1680

agcagctatg ccaaggtcag catctgcctg ccaatggaca ccgacacccc tcttgcactc     1740

gcatacattg tcctcgttct gctgctcaat gttgttgcct ttgttgtcgt ctgttcctgc     1800

tatgtgaaga tctacatcac ggtccgaaat ccccagtaca accctcgaga taaagacacc     1860

aagattgcca agaggatggc tgtgttgatc ttcactgact tcatgtgcat ggcgcccatc     1920

tccttctatg cgctgtcggc acttatgaac aagcctctaa tcactgttac taactccaaa     1980

atcttgttgg ttctcttcta ccccctcaac tcctgtgcca atccgtttct ctatgctatt     2040

ttcaccaagg ccttccagag ggacgtgttc atcctgctca gcaagtttgg catctgcaaa     2100

cgccaggccc aggcctatca gggtcagaga gtctgtccca acaatagcac tggtattcag     2160

atccaaaaga ttccccagga cacgaggcag agtctcccca acatgcaaga tacctatgaa     2220

ctgcttggaa actcccagct agctccaaaa ctgcagggac aaatctcaga agagtataag     2280

caaacagcct tgtaa                                                      2295


<210>  68
<211>  764
<212>  PRT
<213>  Mus musculus

<400>  68

Met Arg Pro Gly Ser Leu Leu Leu Leu Val Leu Leu Leu Ala Leu Ser 
1               5                   10                  15      


Arg Ser Leu Arg Gly Lys Glu Cys Ala Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Asp Asp Phe Arg Val Thr Cys Lys Glu Leu His Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr Cys Leu 
    50                  55                  60                  


Lys Thr Ile Pro Ser Leu Ala Phe Ser Ser Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Leu Ser Ile Asp Ala Thr Leu Gln Arg Leu Glu Pro His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Met Thr His Ile Glu Ile Arg Asn Thr Pro 
            100                 105                 110         


Ser Leu Thr Tyr Ile Asp Pro Asp Ala Leu Thr Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Arg Ile Phe Pro Pro Leu 
    130                 135                 140                 


Thr Lys Ile Tyr Ser Thr Glu Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Val Pro Arg Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly His Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Ala Ile Asp Asn Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Thr Leu Leu Asp Val Ser Ser Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Arg Ala Lys Asp 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Ile Arg Asn Leu Arg Gln Arg Lys Ser Val Asn Ile Leu Arg Gly 
305                 310                 315                 320 


Pro Ile Tyr Gln Glu Tyr Glu Glu Asp Pro Gly Asp Asn Ser Val Gly 
                325                 330                 335     


Tyr Lys Gln Asn Ser Lys Phe Gln Glu Ser Pro Ser Asn Ser His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Val Val Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Glu Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Val Cys Gly Asp Asn Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Arg Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Ile Phe Val Leu Leu Ile Leu Leu Thr Ser His Tyr Lys Leu Thr Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Val Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Tyr Thr Ile Met Ala Gly 
    530                 535                 540                 


Gly Trp Val Ser Cys Phe Leu Leu Ala Leu Leu Pro Met Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Asp Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Val Leu Val Leu Leu Leu Asn Val Val 
            580                 585                 590         


Ala Phe Val Val Val Cys Ser Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Arg Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Met Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Leu Met Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Thr Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Gln Gly Gln Arg Val Cys Pro Asn Asn Ser Thr Gly Ile Gln 
705                 710                 715                 720 


Ile Gln Lys Ile Pro Gln Asp Thr Arg Gln Ser Leu Pro Asn Met Gln 
                725                 730                 735     


Asp Thr Tyr Glu Leu Leu Gly Asn Ser Gln Leu Ala Pro Lys Leu Gln 
            740                 745                 750         


Gly Gln Ile Ser Glu Glu Tyr Lys Gln Thr Ala Leu 
        755                 760                 


<210>  69
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  69
tccgatgagt tcaacccgtg taaggacata atgggctaca agttc                       45


<210>  70
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  70
gatgagttca acccgtgtga aaagataatg ggctacaagt tcctg                       45


<210>  71
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  71
ctgcttattc tcctcaccag caactacaaa ctgaacgtcc cccgc                       45


<210>  72
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  72
aaactgaacg tcccccgctt ttacatgtgc aacctggcct ttgcg                       45


<210>  73
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  73
gtcccccgct ttctcatgtg cgccctggcc tttgcggatt tctgc                       45


<210>  74
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  74
ctggcctttg cggatttctg cgtggggatg tacctgctcc tcatc                       45


<210>  75
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  75
gcggatttct gcatggggat gttcctgctc ctcatcgcct ctgta                       45


<210>  76
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  76
gatttctgca tggggatgta ccccctcctc atcgcctctg tagac                       45


<210>  77
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  77
atcgcctctg tagacctcta catccactct gagtactaca accat                       45


<210>  78
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  78
tacaaccatg ccatcgactg gcacacaggc cctgggtgca acacg                       45


<210>  79
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  79
gtgggaataa gtagctatgc cctggtcagt atctgcctgc ccatg                       45


<210>  80
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  80
acgctcaaca tagttgcctt catcatcgtc tgctgctgtt atgtg                       45


<210>  81
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  81
gccttcgtca tcgtctgctg caggtatgtg aagatctaca tcaca                       45


<210>  82
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  82
ttcgtcatcg tctgctgctg tttcgtgaag atctacatca cagtc                       45


<210>  83
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  83
tcattctatg ctctgtcagc actgctgaac aagcctctca tcact                       45


<210>  84
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  84
ctcatcactg ttagcaactc cgacatcttg ctggtactct tctat                       45


<210>  85
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  85
aaaatcttgc tggtactctt cgtgccactt aactcctgtg ccaat                       45


<210>  86
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  86
gtactcttct atccacttaa cgcctgtgcc aatccattcc tctat                       45


<210>  87
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  87
tcctgtgcca atccattcct cctggctatt ttcaccaagg ccttc                       45


<210>  88
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  88
tcctgtgcca atccattcct cgccgctatt ttcaccaagg ccttc                       45


<210>  89
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  89

Ser Asp Glu Phe Asn Pro Cys Lys Asp Ile Met Gly Tyr Lys Phe 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  90

Asp Glu Phe Asn Pro Cys Glu Glu Ile Met Gly Tyr Lys Phe Leu 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  91

Leu Leu Ile Leu Leu Thr Ser Asn Tyr Lys Leu Asn Val Pro Arg 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  92

Lys Leu Asn Val Pro Arg Phe Tyr Met Cys Asn Leu Ala Phe Ala 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  93

Val Pro Arg Phe Leu Met Cys Ala Leu Ala Phe Ala Asp Phe Cys 
1               5                   10                  15  


<210>  94
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  94

Leu Ala Phe Ala Asp Phe Cys Val Gly Met Tyr Leu Leu Leu Ile 
1               5                   10                  15  


<210>  95
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  95

Ala Asp Phe Cys Met Gly Met Phe Leu Leu Leu Ile Ala Ser Val 
1               5                   10                  15  


<210>  96
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  96

Asp Phe Cys Met Gly Met Tyr Pro Leu Leu Ile Ala Ser Val Asp 
1               5                   10                  15  


<210>  97
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  97

Ile Ala Ser Val Asp Leu Tyr Ile His Ser Glu Tyr Tyr Asn His 
1               5                   10                  15  


<210>  98
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  98

Tyr Asn His Ala Ile Asp Trp His Thr Gly Pro Gly Cys Asn Thr 
1               5                   10                  15  


<210>  99
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  99

Val Gly Ile Ser Ser Tyr Ala Leu Val Ser Ile Cys Leu Pro Met 
1               5                   10                  15  


<210>  100
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  100

Thr Leu Asn Ile Val Ala Phe Ile Ile Val Cys Cys Cys Tyr Val 
1               5                   10                  15  


<210>  101
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  101

Ala Phe Val Ile Val Cys Cys Arg Tyr Val Lys Ile Tyr Ile Thr 
1               5                   10                  15  


<210>  102
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  102

Phe Val Ile Val Cys Cys Cys Phe Val Lys Ile Tyr Ile Thr Val 
1               5                   10                  15  


<210>  103
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  103

Ser Phe Tyr Ala Leu Ser Ala Leu Leu Asn Lys Pro Leu Ile Thr 
1               5                   10                  15  


<210>  104
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  104

Leu Ile Thr Val Ser Asn Ser Asp Ile Leu Leu Val Leu Phe Tyr 
1               5                   10                  15  


<210>  105
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  105

Lys Ile Leu Leu Val Leu Phe Val Pro Leu Asn Ser Cys Ala Asn 
1               5                   10                  15  


<210>  106
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  106

Val Leu Phe Tyr Pro Leu Asn Ala Cys Ala Asn Pro Phe Leu Tyr 
1               5                   10                  15  


<210>  107
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  107

Ser Cys Ala Asn Pro Phe Leu Leu Ala Ile Phe Thr Lys Ala Phe 
1               5                   10                  15  


<210>  108
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  108

Ser Cys Ala Asn Pro Phe Leu Ala Ala Ile Phe Thr Lys Ala Phe 
1               5                   10                  15  


