                         SEQUENCE LISTING

<110>  Temasek Life Sciences Laboratory Limited
 
<120>  Development of Stable Cold-Adapted Temperature Sensitive Chimeric
        Enteroviruses

<130>  2577-236PCT

<150>  US 62/011,406
<151>  2014-06-14

<160>  88    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  1
ccggggaaac agaagtgctt gatc                                              24


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonculeotide primer

<400>  2
attcaggggc cggaggacta c                                                 21


<210>  3
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  3
gacacccaaa gtagtcggtt ccg                                               23


<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  4
aacagcctgt gggttgcacc cac                                               23


<210>  5
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  5
tagtcctccg gcccctgaat gc                                                22


<210>  6
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  6
gaattccgtc tgggaggaca gct                                               23


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  7
ctaccgtggc accctatcag agct                                              24


<210>  8
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  8
aggagtgatt atgacatggt cactctcac                                         29


<210>  9
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  9
tatccatcaa agtggtccgg gtctg                                             25


<210>  10
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  10
agagcaaaca ccgaattgaa cctgtatgtc                                        30


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  11
gctgaatggc cttcccacac ac                                                22


<210>  12
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  12
caatggcttc cctagaagag aaaggagt                                          28


<210>  13
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  13
caaccttgat ctctacagta ctggcgt                                           27


<210>  14
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  14
acacaattga agcactattc caaggtccg                                         29


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  15
ccagattgtt ttgccgggct gg                                                22


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  16
aacagtgcag ggtccaagtc tcg                                               23


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  17
tattgggctt gacccactgg atctc                                             25


<210>  18
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  18
caacccaccg taccatgatg tacaac                                            26


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  19
aatggcctca aggttctcag tgcc                                              24


<210>  20
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  20
gacacctccc agatgagcat ggag                                              24


<210>  21
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  21
ccagggagta agatgggtag tttactcc                                          28


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  22
tgaaaccttc catgcaaacc ctgg                                              24


<210>  23
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  23
atttgtctgc aggagtcatg gttaaaccg                                         29


<210>  24
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  24
gatgatgtgc ttgccagtta ccct                                              24


<210>  25
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  25
tttttttttt tttttttttt tttttgctat tctggtaata acaaatttac cc               52


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  26
ccaaaattgc aatggttcag ggcag                                             25


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  27
gagctgtcct cccagacgga a                                                 21


<210>  28
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  28
ctcaccataa ccgactatga tgtttgcc                                          28


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  29
gcgtggcaca actcaccatt g                                                 21


<210>  30
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  30
tacgtgcttg atgctgggat tcc                                               23


<210>  31
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  31
acacggcaca caattcacct ttccc                                             25


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  32
accaccgatg acggcgtctc ag                                                22


<210>  33
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  33
ggtaaaattc ttctgggctg ccgc                                              24


<210>  34
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  34
tgtcaccctt gtgataccat ggatcag                                           27


<210>  35
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  35
gtgtgagtta agaacgcacc gtgtttc                                           27


<210>  36
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  36
tgatgagagt atgattgaaa cacggtgcg                                         29


<210>  37
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  37
aaaaccactg gtaagcgctc gc                                                22


<210>  38
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  38
cacaaacccc tcaatttttg tcaagttgac                                        30


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  39
gcactttctc ggtgcggact g                                                 21


<210>  40
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  40
tagagaagct gactggatag tgctttctc                                         29


<210>  41
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  41
ccatagccaa ctatgatgtt tgc                                               23


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  42
cgggtggcrc aattaactat tgg                                               23


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  43
tacgtgctcg atgctggsat ycc                                               23


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  44
acacggcaca carytcacct ttccc                                             25


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  45
cacccttgta ataccatgga tcag                                              24


<210>  46
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  46
gtgaattaag aacrcaycgt gtyt                                              24


<210>  47
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  47
tcgtcaaatr ctagtgatga gagt                                              24


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  48
aaccaytgrt argcgctcgc rggt                                              24


<210>  49
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  49
gccacwaayc cctcagtttt tg                                                22


<210>  50
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  50
gatgggtacr ttctcagtgc ggac                                              24


<210>  51
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  51
ccggtgacca acagagctat tgtttacc                                          28


<210>  52
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  52
ataccatccc tttgaatcct tggccc                                            26


<210>  53
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  53
agtactgccc agacacagat gcaa                                              24


<210>  54
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  54
ttctcaggtt gatccactga tgtggg                                            26


<210>  55
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  55
actacacagc ctggtcaggt tgg                                               23


<210>  56
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  56
atctcttcca gggtctgctc taaaggc                                           27


<210>  57
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  57
acaacctgaa gaccaatgag accacc                                            26


<210>  58
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  58
acttgcttca gtattggcag ctgtagg                                           27


<210>  59
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  59
gacacagagg acattgagca aacagc                                            26


<210>  60
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  60
tttctcaaag gccttgggat ccatgcc                                           27


<210>  61
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  61
tgatggttat cccaccttyg gwgagc                                            26


<210>  62
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  62
attcaggggc cggaggacta c                                                 21


<210>  63
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  63
gaagagaagg tggaaatggc gttttgg                                           27


<210>  64
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  64
ccaaaacgcc atttccacct tctcttc                                           27


<210>  65
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  65
ccggggaaac agaagtgctt gatc                                              24


<210>  66
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  66
gagaatctga gamgmaattg gctcg                                             25


<210>  67
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  67
tttttttttt ttttt                                                        15


<210>  68
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  68
gggactaccr tgrcamccka tcag                                              24


<210>  69
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  69
gctaggatcc taatacgact cactataggt taaaacagcc tgtgggttgc acccac           56


<210>  70
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  70
cgatgacgtc cggccgaact ttccaagggt agtaatgg                               38


<210>  71
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  71
tcgaggatcc ggccggcaat ctggggccat gtacg                                  35


<210>  72
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  72
gatcgacgtc tttttttttt tttttttttt tttttgctat tctggtaata acaaatttac       60

cc                                                                      62


<210>  73
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  73
caacgcgtcg gctcccacga gaactcc                                           27


<210>  74
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  74
gccgacgcgt tgagtagaca cttgtgagcc                                        30


<210>  75
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  75
atcgatcgat cacacaacgc gtcggctcgc atgaaaactc taac                        44


<210>  76
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  76
tatacccggg ttgtcggccg aatttcccaa gagtggtgat cgccgtg                     47


<210>  77
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  77
cagtcgcacg acgatcacca ctcttgggaa attcggccga c                           41


<210>  78
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  78
tggtgatcgt cgtgcgactg gcaccggttg gcttaataga atcacc                      46


<210>  79
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  79
tctcgctagc acgcgtcggg tcacatgaga actcaaactc tg                          42


<210>  80
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  80
tctcgctagc acgcgtcggg tcacatgaga actcaaactc tgtgcactcg agtgccggcc       60

gaactctccc aatgttgtta tcttg                                             85


<210>  81
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  81
ctagtagaga cacgataaca acattgggag agttcggccg gcactc                      46


<210>  82
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  82
aactctccca atgttgttat cgtgtctcta ctagtgctag tgcacttaat atcatttc         58


<210>  83
<211>  7437
<212>  DNA
<213>  Enterovirus 71, strain EV71:TLLbetaP20

<400>  83
ttaaaacagc ctgtgggttg cacccactca cagggcccac gtggcgctag cactctgatt       60

ctacggaatc tttgtgcgcc tgttttacaa ccccccccaa tttgcaactt agaagcaata      120

cacaacactg atcaacagca ggcatggcgc accagccatg tcttgatcaa gcacttctgt      180

ttccccggac tgagtatcaa tagactgctc acgcggttga aggagaaagc gtccgttatc      240

cggctaacta cttcgagaaa cctagtagca ccattgaaac tgcggagtgt ttcgctcggc      300

acttcccccg tgtagatcag gtcgatgagt cactgcaatc cccacgggcg accgtggcag      360

tggctgcgct ggcggcctgc ctatggggca acccatagga cgctctaatg tggacatggt      420

gcgaagagtc tattgagcta gttagtagtc ctccggcccc tgaatgcggc taatcctaac      480

tgcggagcac atgccctcaa cccagagggt agtgtgtcgt aacgggcaac tctgcagcgg      540

aaccgactac tttgggtgtc cgtgtttcct tttattctta cattggctgc ctatggtgac      600

aatcgcagaa ttgttaccat atagctattg gattggccat ccggtgtgca atagagctat      660

tatataccta tttgttggct ttgtaccatt aaccttaaaa tctataacta ccctcaactt      720

tgtattaact ctcaatacag tcaaacatgg gctcacaagt gtctactcag cgatccggct      780

cccacgagaa ctccaattca gctacggaag gctctaccat taattacact accatcaact      840

attacaaaga ctcctatgct gcaacagcag gcaaacagag cctcaaacaa gaccctgata      900

agtttgctaa ccctgttaag gatattttca ctgaaatggc tgcgccactg aagtctccat      960

ccgctgaagc ttgtggttat agtgatcgcg tggcacaact caccattgga aactccacca     1020

ttactacaca ggaggcggca aacatcatag tcggttatgg tgagtggccc tcatattgct     1080

ctgatgacga tgctacagcg gtggataaac caacgcgccc agatgtgtca gtgaataggt     1140

tttatacatt ggacaccaaa ctgtgggaaa aatcatctaa ggggtggtat tggaagtttc     1200

ctgatgtatt gactgagacc ggagtctttg gccagaacgc acagtttcac tatttatata     1260

gatcagggtt ttgcattcat gtgcaatgta atgctagcaa gttccatcaa ggagcgctgt     1320

tagtcgctat tcttccagag tatgttatag ggacagtggc aggcggcaca ggtacagagg     1380

acagccaccc tccttacaaa caaacacaac ctggcgctga tggttttgag ctgcagcacc     1440

cgtacgtgct tgatgctggg attcctatat cacaactgac agtgtgcccc catcaatgga     1500

ttaatctgcg gaccaataac tgtgccacga taatagtgcc atatatgaac acactgcctt     1560

tcgactctgc ccttaaccat tgcaattttg ggctgttggt agtgcccatt agcccattag     1620

attttgacca aggggcaact ccagttatcc ctattacaat cactctagct ccaatgtgct     1680

ctgagtttgc aggtctcaga caggcagtca ctcaaggctt ccctactgag ccaaaaccag     1740

gaacaaatca atttttgacc accgatgacg gcgtctcagc acccattcta ccaaatttcc     1800

accccactcc atgtattcgc atacccggtg aagtcagaaa cctgcttgag ttgtgtcaag     1860

tggagactat tcttgaggtt aacaacgtac ccaccaatga taccagtttg atggaaaggc     1920

tacgatttcc agtgtctgcg caagcgggga aaggtgaatt gtgtgccgtg tttagggccg     1980

accctggaag ggacggtcca tggcaatcaa caatgctggg ccagctgtgt ggatactaca     2040

cccagtggtc aggatcactg gaggtcactt ttatgtttac cgggtctttt atggccacgg     2100

gtaaaatgct catagcctat acacctcctg gtggcccctt acctaaagac cgggctacag     2160

caatgctggg cacgcatgtt atctgggatt ttgggttaca atcatctgtc acccttgtga     2220

taccatggat cagtaacacc cactacagag cgcatgcccg ggacggagtg ttcgattact     2280

ataccacagg actggtcagt atctggtatc aaacaaacta cgtagttcca attggggcac     2340

ccaacacagc ttacataata gcactagcgg cagcccagaa gaattttacc atgaaactgt     2400

gcaaagacac tagtcacata ttacagacag cctccattca gggagatagg gtggcagatg     2460

tgatcgagag ctctatagga aatagtgtga gtagagcact tacccaggcc ctgccggcac     2520

ccacaggtca aaacacacag gtgagcagcc accgactaga cactggcgaa gttccagcgc     2580

tccaagctgc tgaaattggg gcatcgtcaa atactagtga tgagagtatg attgaaacac     2640

ggtgcgttct taactcacac agcacagcag aaaccacctt ggatagcttc ttcagtaggg     2700

caggtttggt aggggagata gatctccctc ttaagagcat tactaatctg aatggttatg     2760

tcaactggga tatagacata actggttacg cacagatgcg caggaaagtg gagttgttca     2820

cctacatgcg ctttgatgcg gaattcactt ttgttgcgtg cactcccacc ggcgaggttg     2880

ttccacaatt tctccagtat atgtttgttc cccctggtgc tcccaaacca gaatctagag     2940

aatcacttgc ttggcaaaca gccacaaacc cctcaatttt tgtcaagttg actgatcccc     3000

cagcacaggt ctcagttcca ttcatgtcac ccgcgagcgc ttaccagtgg ttttacgacg     3060

ggtaccctac gtttggagaa cataaacagg agaaagacct tgagtatgga gcgtgtccta     3120

ataatatgat gggcactttc tcggtgcgga ctgtggggtc agcaaagtcc aagtaccctc     3180

tggttgtcag aatatatatg agaatgaaac atgtcagggc atggatacct cgtccgatgc     3240

gcaaccaaaa ctacttgttc aaagccaatc cgaactacgc tggcaactcc attaaaccga     3300

ccggcactag ccgtaatacc attactaccc ttggaaagtt tggccagcaa tctggggcca     3360

tctacgtggg caacttcaga gtggttaatc gtcacctcgc tactcataat gactgggcga     3420

attccgtctg ggaggacagc tcccgcgacc tactagtgtc gtctactact gcccagggct     3480

gtgatacaat tgcacgttgt gactgtcaaa caggagtgta ctattgtaac tctaagagaa     3540

agcactatcc agtcagcttc tctaaaccta gcctcactta tgtggaagct agcgagtatt     3600

accctgctag ataccagtct catctcatgc ttgcggcggg tcattctgaa ccaggagatt     3660

gtggtggcat ccttaggtgc cagcacggtg ttgtcggcat tgtgtccact ggtggcaacg     3720

ggcttgttgg ctttgcagat gtcagggatc tcctatggtt ggatgaagaa gcaatggagc     3780

agggtgtgtc cgactacatt aagggacttg gtgatgcgtt tggaactggc ttcaccgatg     3840

cagtttccag agaagttgag gctcttaaga gccaccttat tgggtctgaa ggagttgtcg     3900

agaagatcct aaagaatttg atcaaattaa tctctgcttt agtcatcgtg attaggagtg     3960

attatgacat ggtcactctc acagcaactt tagctctgat agggtgccac ggtagtccct     4020

gggcatggat taaagcaaaa acagcttcca ttctaggcat ccctattgcc cagaagcaaa     4080

gtgcgtcctg gcttaaaaaa tttaacgata tggccaacgc cgccaagggg ttagagtgga     4140

tctccagtaa gattagtaaa ttcatcgatt ggctcaaaga gaaaatcata ccagcggcta     4200

gggagaaggt ggagtttctg aacaacttaa aacagttgcc gttgctggag aatcagatct     4260

caaatctaga gcagtctgct gcttcacaag aaaatctcga agccatgttc ggaaatgtgt     4320

cgtacctagc tcacttctgc cgcaaattcc aaccactgta cgctacagaa gccaaaaggg     4380

tctatgcttt ggagaaaaga atgaacaact acatgcagtt caagagcaaa caccgaattg     4440

aacctgtatg tcttattatt aggggttctc cgggcaccgg gaaatcacta gcaactggca     4500

tcattgctcg ggcaatagca gacaagtatc actcaagtgt gtactcactc ccaccagacc     4560

cggaccactt tgatggatac aaacagcagg tggtcacggt catggatgac ttatgtcaga     4620

accctgacgg caaagatatg tcattgttct gccagatggt gtccacagtg gatttcatcc     4680

caccaatggc ttccctagaa gagaaaggag tttctttcac atctaaattt gtcattgcat     4740

ctactaattc cagcaacatc atagtaccaa cagtgtctga ttctgatgca attcgccgta     4800

ggttctatat ggattgtgat atcgaagtca cggattcata caaaacggac ttgggtaggt     4860

tagatgctgg gcgagccgcc aaattgtgct ctgagaataa cacagcaaat ttcaagcgtt     4920

gtagcccact agtgtgtggg aaggccattc agctgagaga tagaaagtcc aaggtcaggt     4980

acagtgtgga cacggtggtt tctgagctca taagggaata caacaacagg tctgctatcg     5040

gtaacacaat tgaagcacta ttccaaggtc cgcctaagtt taaacccata aggattagtc     5100

ttgaagaaaa gccagcccca gacgccatta gtgaccttct tgctagtgtg gatagcgagg     5160

aggtacgcca gtactgtaga gatcaaggtt ggatcattcc agagactcct acaaatgttg     5220

aacggcacct caacagagct gtgctagtca tgcaatccat cactacagtt gtggcagtcg     5280

tttcactggt gtacgtcatc tacaagctct tcgctggatt ccaaggcgcg tactctggtg     5340

ctcccaagca gatactcaag aaacccgttc tccgcacggc aacagtgcag ggtccaagtc     5400

tcgatttcgc tctgtctcta ctaaggagga atatcaggca agtgcaaaca gatcaaggac     5460

attttaccat gctgggtgtc agggaccgtt tggctgttct tccacgccac tcccagcccg     5520

gcaaaacaat ctgggtagag cacaaactcg taaacattct ggacgctgtt gaactggtgg     5580

atgaacaagg ggtcaatttg gagctaaccc taatcaccct tgacactaat gagaaattca     5640

gagacattac taagttcatc ccggagagca tcagcactgc aagcgatgct accctagtga     5700

tcaacacaga gcacatgccc tcaatgtttg tgccggtggg ggacgttgtg caatatggtt     5760

ttctcaacct tagtggaaag ccaacccacc gtaccatgat gtacaacttt cccaccaagg     5820

cagggcagtg tggaggggtg gtgacatcag ttggaaaggt cattggtata cacataggtg     5880

gtaacggcag acaaggtttc tgtgcgggac ttaagaggag ctatttcgcc agcgagcaag     5940

gagagatcca gtgggtcaag cccaataaag aaactgggag actcaacatc aatgggccaa     6000

ctcgcactaa gctcgaaccc agtgtatttc atgatgtttt tgagggaaac aaggagccag     6060

cagttctaca cagtaaagat ccccgcctcg aggtggattt tgagcaggct ttgttctcca     6120

agtacgtagg gaatacacta tatgagcctg atgattacat taaggaggca gctcttcact     6180

acgcaaatca gttgaaacag ctggacattg acacctccca gatgagcatg gaggaagcct     6240

gttacggcac tgagaacctt gaggccattg atcttcacac tagtgcaggt tacccataca     6300

gtgctctagg aataaagaaa agagacatcc tagattctac tactagggat gtgagcaaga     6360

tgaaatttta tatggacaag tatggcttgg acctacccta ctccacctat gtcaaggatg     6420

agctacgctc gatagataag atcaagaaag ggaagtctcg tttgattgaa gccagcagct     6480

taaatgattc tgtgtacctt aggatgactt ttgggcacct ttatgaaacc ttccatgcaa     6540

accctggaac tgtgaccggt tcagccgtgg gatgcaatcc ggatacattc tggagtaaac     6600

tacccatctt actccctggc tcactctttg ctttcgacta ttcaggatat gatgctagtc     6660

ttagccctgt ctggttcagg gcattagaat tagttcttag ggaaataggc tacagtgagg     6720

aagcagtttc acttgttgag gggatcaatc acacgcacca tgtataccgc aacaaaactt     6780

actgtgtgct tggtggcatg ccctctggtt gctcaggaac atccatattc aattcaatga     6840

tcaataacat tattattaga gcactgctca tcaaaacgtt caagggcatt gatttagacg     6900

agctcaacat ggttgcctat ggggatgatg tgcttgccag ttaccctttt ccaattgact     6960

gcttggagtt ggcaagaaca ggcaaggagt acggtttaac catgactcct gcagacaaat     7020

ccccatgctt caatgaagtc aattgggata acgcaacctt tctcaaaaga ggcttcttgc     7080

ccgatgaaca atttccattc cttatccacc ctaccatgcc aatgaaagaa atccacgagt     7140

ccatacggtg gaccaaggac gcgcgaaata cccaagatca cgtgcggtcc ttgtgccttc     7200

tggcatggca caatggtaaa caggaatatg aaaagtttgt gagcgcaatt agatcagtac     7260

cagtaggaaa agtattggct attccaaatt atgagaatct gagacgcaat tggctcgaac     7320

tattttagag gttaagtata tacctcaacc ccaccaggaa tctggtcgtg aacatgactg     7380

gtgggggtaa atttgttatt accagaatag caaaaaaaaa aaaaaaaaaa aaaaaaa        7437


<210>  84
<211>  7446
<212>  DNA
<213>  Enterovirus 71, strain EV71:eTLLbetaP20

<400>  84
ttaaaacagc ctgtgggttg cacccactca cagggcccac gtggcgctag cactctgatt       60

ctacggaatc tttgtgcgcc tgttttacaa ccccccccaa tttgcaactt agaagcaata      120

cacaacactg atcaacagca ggcatggcgc accagccatg tcttgatcaa gcacttctgt      180

ttccccggac tgagtatcaa tagactgctc acgcggttga aggagaaagc gtccgttatc      240

cggctaacta cttcgagaaa cctagtagca ccattgaaac tgcggagtgt ttcgctcggc      300

acttcccccg tgtagatcag gtcgatgagt cactgcaatc cccacgggcg accgtggcag      360

tggctgcgct ggcggcctgc ctatggggca acccatagga cgctctaatg tggacatggt      420

gcgaagagtc tattgagcta gttagtagtc ctccggcccc tgaatgcggc taatcctaac      480

tgcggagcac atgccctcaa cccagagggt agtgtgtcgt aacgggcaac tctgcagcgg      540

aaccgactac tttgggtgtc cgtgtttcct tttattctta cattggctgc ctatggtgac      600

aatcgcagaa ttgttaccat atagctattg gattggccat ccggtgtgca atagagctat      660

tatataccta tttgttggct ttgtaccatt aaccttaaaa tctataacta ccctcaactt      720

tgtattaact ctcaatacag tcaaacatgg gcttacaagt gtctactcaa cgcgtcggct      780

cccacgagaa ctccaattca gctacggaag gctctaccat taattacact accatcaact      840

attacaaaga ctcctatgct gcaacagcag gcaaacagag cctcaaacaa gaccctgata      900

agtttgctaa ccctgttaag gatattttca ctgaaatggc tgcgccactg aagtctccat      960

ccgctgaagc ttgtggttat agtgatcgcg tggcacaact caccattgga aactccacca     1020

ttactacaca ggaggcggca aacatcatag tcggttatgg tgagtggccc tcatattgct     1080

ctgatgacga tgctacagcg gtggataaac caacgcgccc agatgtgtca gtgaataggt     1140

tttatacatt ggacaccaaa ctgtgggaaa aatcatctaa ggggtggtat tggaagtttc     1200

ctgatgtatt gactgagacc ggagtctttg gccagaacgc acagtttcac tatttatata     1260

gatcagggtt ttgcattcat gtgcaatgta atgctagcaa gttccatcaa ggagcgctgt     1320

tagtcgctat tcttccagag tatgttatag ggacagtggc aggcggcaca ggtacagagg     1380

acagccaccc tccttacaaa caaacacaac ctggcgctga tggttttgag ctgcagcacc     1440

cgtacgtgct tgatgctggg attcctatat cacaactgac agtgtgcccc catcaatgga     1500

ttaatctgcg gaccaataac tgtgccacga taatagtgcc atatatgaac acactgcctt     1560

tcgactctgc ccttaaccat tgcaattttg ggctgttggt agtgcccatt agcccattag     1620

attttgacca aggggcaact ccagttatcc ctattacaat cactctagct ccaatgtgct     1680

ctgagtttgc aggtctcaga caggcagtca ctcaaggctt ccctactgag ccaaaaccag     1740

gaacaaatca atttttgacc accgatgacg gcgtctcagc acccattcta ccaaatttcc     1800

accccactcc atgtattcgc atacccggtg aagtcagaaa cctgcttgag ttgtgtcaag     1860

tggagactat tcttgaggtt aacaacgtac ccaccaatga taccagtttg atggaaaggc     1920

tacgatttcc agtgtctgcg caagcgggga aaggtgaatt gtgtgccgtg tttagggccg     1980

accctggaag ggacggtcca tggcaatcaa caatgctggg ccagctgtgt ggatactaca     2040

cccagtggtc aggatcactg gaggtcactt ttatgtttac cgggtctttt atggccacgg     2100

gtaaaatgct catagcctat acacctcctg gtggcccctt acctaaagac cgggctacag     2160

caatgctggg cacgcatgtt atctgggatt ttgggttaca atcatctgtc acccttgtga     2220

taccatggat cagtaacacc cactacagag cgcatgcccg ggacggagtg ttcgattact     2280

ataccacagg actggtcagt atctggtatc aaacaaacta cgtagttcca attggggcac     2340

ccaacacagc ttacataata gcactagcgg cagcccagaa gaattttacc atgaaactgt     2400

gcaaagacac tagtcacata ttacagacag cctccattca gggagatagg gtggcagatg     2460

tgatcgagag ctctatagga aatagtgtga gtagagcact tacccaggcc ctgccggcac     2520

ccacaggtca aaacacacag gtgagcagcc accgactaga cactggcgaa gttccagcgc     2580

tccaagctgc tgaaattggg gcatcgtcaa atactagtga tgagagtatg attgaaacac     2640

ggtgcgttct taactcacac agcacagcag aaaccacctt ggatagcttc ttcagtaggg     2700

caggtttggt aggggagata gatctccctc ttaagagcat tactaatctg aatggttatg     2760

tcaactggga tatagacata actggttacg cacagatgcg caggaaagtg gagttgttca     2820

cctacatgcg ctttgatgcg gaattcactt ttgttgcgtg cactcccacc ggcgaggttg     2880

ttccacaatt tctccagtat atgtttgttc cccctggtgc tcccaaacca gaatctagag     2940

aatcacttgc ttggcaaaca gccacgaacc cctcaatttt tgtcaagttg actgatcccc     3000

cagcacaggt ctcagttcca ttcatgtcac ccgcgagcgc ttaccagtgg ttttacgacg     3060

ggtaccctac gtttggagaa cataaacagg agaaagacct tgagtatgga gcgtgtccta     3120

ataatatgat gggcactttc tcggtgcgga ctgtggggtc agcaaagtcc aagtaccctc     3180

tggttgtcag aatatatatg agaatgaaac atgtcagggc atggatacct cgtccgatgc     3240

gcaaccaaaa ctacttgttc aaagccaatc cgaactacgc tggcaactcc attaaaccga     3300

ccggcactag ccgtaatacc attactaccc ttggaaagtt cggccggcaa tctggggcca     3360

tatacgtggg caacttcaga gtggttaatc gtcacctcgc tactcataat gactgggcga     3420

attccgtctg ggaggacagc tcccgcgacc tactagtgtc gtctactact gcccagggct     3480

gtgatacaat tgcacgttgt gactgtcaaa caggagtgta ctattgtaac tctaagagaa     3540

agcactatcc agtcagcttc tctaaaccta gcctcactta tgtggaagct agcgagtatt     3600

accctgctag ataccagtct catctcatgc ttgcggcggg tcattctgaa ccaggagatt     3660

gtggtggcat ccttaggtgc cagcacggtg ttgtcggcat tgtgtccact ggtggcaacg     3720

ggcttgttgg ctttgcagat gtcagggatc tcctatggtt ggatgaagaa gcaatggagc     3780

agggtgtgtc cgactacatt aagggacttg gtgatgcgtt tggaactggc ttcaccgatg     3840

cagtttccag agaagttgag gctcttaaga gccaccttat tgggtctgaa ggagttgtcg     3900

agaagatcct aaagaatttg atcaaattaa tctctgcttt agtcatcgtg attaggagtg     3960

attatgacat ggtcactctc acagcaactt tagctctgat agggtgccac ggtagtccct     4020

gggcatggat taaagcaaaa acagcttcca ttctaggcat ccctattgcc cagaagcaaa     4080

gtgcgtcctg gcttaaaaaa tttaacgata tggccaacgc cgccaagggg ttagagtgga     4140

tctccagtaa gattagtaaa ttcatcgatt ggctcaaaga gaaaatcata ccagcggcta     4200

gggagaaggt ggagtttctg aacaacttaa aacagttgcc gttgctggag aatcagatct     4260

caaatctaga gcagtctgct gcttcacaag aaaatctcga agccatgttc ggaaatgtgt     4320

cgtacctagc tcacttctgc cgcaaattcc aaccactgta cgctacagaa gccaaaaggg     4380

tctatgcttt ggagaaaaga atgaacaact acatgcagtt caagagcaaa caccgaattg     4440

aacctgtatg tcttattatt aggggttctc cgggcaccgg gaaatcacta gcaactggca     4500

tcattgctcg ggcaatagca gacaagtatc actcaagtgt gtactcactc ccaccagacc     4560

cggaccactt tgatggatac aaacagcagg tggtcacggt catggatgac ttatgtcaga     4620

accctgacgg caaagatatg tcattgttct gccagatggt gtccacagtg gatttcatcc     4680

caccaatggc ttccctagaa gagaaaggag tttctttcac atctaaattt gtcattgcat     4740

ctactaattc cagcaacatc atagtaccaa cagtgtctga ttctgatgca attcgccgta     4800

ggttctatat ggattgtgat atcgaagtca cggattcata caaaacggac ttgggtaggt     4860

tagatgctgg gcgagccgcc aaattgtgct ctgagaataa cacagcaaat ttcaagcgtt     4920

gtagcccact agtgtgtggg aaggccattc agctgagaga tagaaagtcc aaggtcaggt     4980

acagtgtgga cacggtggtt tctgagctca taagggaata caacaacagg tctgctatcg     5040

gtaacacaat tgaagcacta ttccaaggtc cgcctaagtt taaacccata aggattagtc     5100

ttgaagaaaa gccagcccca gacgccatta gtgaccttct tgctagtgtg gatagcgagg     5160

aggtacgcca gtactgtaga gatcaaggtt ggatcattcc agagactcct acaaatgttg     5220

aacggcacct caacagagct gtgctagtca tgcaatccat cactacagtt gtggcagtcg     5280

tttcactggt gtacgtcatc tacaagctct tcgctggatt ccaaggcgcg tactctggtg     5340

ctcccaagca gatactcaag aaacccgttc tccgcacggc aacagtgcag ggtccaagtc     5400

tcgatttcgc tctgtctcta ctaaggagga atatcaggca agtgcaaaca gatcaaggac     5460

attttaccat gctgggtgtc agggaccgtt tggctgttct tccacgccac tcccagcccg     5520

gcaaaacaat ctgggtagag cacaaactcg taaacattct ggacgctgtt gaactggtgg     5580

atgaacaagg ggtcaatttg gagctaaccc taatcaccct tgacactaat gagaaattca     5640

gagacattac taagttcatc ccggagagca tcagcactgc aagcgatgct accctagtga     5700

tcaacacaga gcacatgccc tcaatgtttg tgccggtggg ggacgttgtg caatatggtt     5760

ttctcaacct tagtggaaag ccaacccacc gtaccatgat gtacaacttt cccaccaagg     5820

cagggcagtg tggaggggtg gtgacatcag ttggaaaggt cattggtata cacataggtg     5880

gtaacggcag acaaggtttc tgtgcgggac ttaagaggag ctatttcgcc agcgagcaag     5940

gagagatcca gtgggtcaag cccaataaag aaactgggag actcaacatc aatgggccaa     6000

ctcgcactaa gctcgaaccc agtgtatttc atgatgtttt tgagggaaac aaggagccag     6060

cagttctaca cagtaaagat ccccgcctcg aggtggattt tgagcaggct ttgttctcca     6120

agtacgtagg gaatacacta tatgagcctg atgattacat taaggaggca gctcttcact     6180

acgcaaatca gttgaaacag ctggacattg acacctccca gatgagcatg gaggaagcct     6240

gttacggcac tgagaacctt gaggccattg atcttcacac tagtgcaggt tacccataca     6300

gtgctctagg aataaagaaa agagacatcc tagattctac tactagggat gtgagcaaga     6360

tgaaatttta tatggacaag tatggcttgg acctacccta ctccacctat gtcaaggatg     6420

agctacgctc gatagataag atcaagaaag ggaagtctcg tttgattgaa gccagcagct     6480

taaatgattc tgtgtacctt aggatgactt ttgggcacct ttatgaaacc ttccatgcaa     6540

accctggaac tgtgaccggt tcagccgtgg gatgcaatcc ggatacattc tggagtaaac     6600

tacccatctt actccctggc tcactctttg ctttcgacta ttcaggatat gatgctagtc     6660

ttagccctgt ctggttcagg gcattagaat tagttcttag ggaaataggc tacagtgagg     6720

aagcagtttc acttgttgag gggatcaatc acacgcacca tgtataccgc aacaaaactt     6780

actgtgtgct tggtggcatg ccctctggtt gctcaggaac atccatattc aattcaatga     6840

tcaataacat tattattaga gcactgctca tcaaaacgtt caagggcatt gatttagacg     6900

agctcaacat ggttgcctat ggggatgatg tgcttgccag ttaccctttt ccaattgact     6960

gcttggagtt ggcaagaaca ggcaaggagt acggtttaac catgactcct gcagacaaat     7020

ccccatgctt caatgaagtc aattgggata acgcaacctt tctcaaaaga ggcttcttgc     7080

ccgatgaaca atttccattc cttatccacc ctaccatgcc aatgaaagaa atccacgagt     7140

ccatacggtg gaccaaggac gcgcgaaata cccaagatca cgtgcggtcc ttgtgccttc     7200

tggcatggca caatggtaaa caggaatatg aaaagtttgt gagcgcaatt agatcagtac     7260

cagtaggaaa agtattggct attccaaatt atgagaatct gagacgcaat tggctcgaac     7320

tattttagag gttaagtata tacctcaacc ccaccaggaa tctggtcgtg aacatgactg     7380

gtgggggtaa atttgttatt accagaatag caaaaaaaaa aaaaaaaaaa aaaaaaaaaa     7440

aaaaaa                                                                7446


<210>  85
<211>  2586
<212>  DNA
<213>  Enterovirus 71, strain C5

<400>  85
atgggctcac aggtgtccac acaacgctcc ggctcgcatg aaaactctaa ctcagctact       60

gagggttcta ccataaacta cactaccatc aattactata aggactccta tgccgccaca      120

gcaggcaaac agagtcttaa gcaggatcca gacaagtttg caaatcctgt caaagatatt      180

ttcactgaaa tggcagcccc actaaaatcc ccatccgctg aggcatgtgg gtacagcgat      240

cgagtagcgc agttaactat cggcaactcc accatcacta cgcaagaagc agcaaacatt      300

atagttgggt atggtgagtg gccctcctac tgctcagatt ctgacgctac ggcggtggac      360

aaaccgacgc gcccagatgt gtcggtgaat agattctaca cattggacac caaattgtgg      420

gagaaatcgt ccaaaggatg gtattggaaa ttcccggatg tgttaacaga aactggggtc      480

tttgggcaaa atgcacaatt ccactatctc tatcggtcag ggttctgcat tcacgtgcaa      540

tgcaatgcta gtaaatttca ccaaggggcg ctcttagtcg ctgtcctccc agagtatgtc      600

attgggacgg tggctggagg cacaggaacg gaggatagtc acccccctta tatgcaaacc      660

caacccggcg ctgatggttt tgagctgcaa cacccgtacg tgcttgacgc tggtatcccg      720

atatcacaat tgacagtgtg cccacaccag tggattaatt tgaggactaa taattgtgcc      780

acaataatag tgccgtacat aaatgcacta cccttcgatt ctgctttgaa ccattgcaac      840

tttggcctat tggtcgtgcc tattagcccg ttagactttg atcaaggagc gacgccggtg      900

atccctatca ccatcacatt ggccccaatg tgctctgaat ttgcgggtct taggcaagca      960

gtcacgcagg gatttcccac tgagctaaaa cctggcacaa accaattttt aactactgac     1020

gacggtgttt cagcgcccat tttgccaaac ttttacccca ctccatgcat ccatatacct     1080

ggtgaagtta ggaatctgtt agagttgtgt caggtggaga ccattttaga agtcaataac     1140

gtgcccacga atgccactag cttaatggag agactgcggt ttccggtctc agcccaagcg     1200

gggaagggtg agttgtgtgc agtgttcaga gccgaccctg ggcggagtgg gccatggcag     1260

tctactttat tgggtcagtt atgcgggtat tacactcaat ggtcaggatc actggaagtc     1320

actttcatgt ttactgggtc ctttatggcc actggcaaga tgcttatagc ctacacaccg     1380

ccgggaggtc ccctacccaa ggaccgggcg accgccatgt tgggtacgca tgtcatctgg     1440

gatttcgggc tacaatcgtc tgttactctt gtaataccat ggattagcaa cacccactac     1500

agggcgcatg ctcgagatgg agtgttcgac tactatacca caggcttggt tagtatatgg     1560

tatcagacga attatgtagt tccaattggg gcacccaaca cagcctatat aattgcacta     1620

gcggcggccc agaagaattt caccatgaag ttgtgcaaag atgccagtga catcctgcag     1680

acaggcacta tccagggaga cagggtggcg gatgtgatag aaagttctat aggggacagc     1740

gtgagtagag ccctcaccca agccctaccg gcacctacag gccagaacac gcaggtaagc     1800

agccaccgac tagacactgg taaagtccca gcgcttcaag ccgctgagat tggagcatcg     1860

tcaaacgcta gcgatgagag catgattgag acacggtgtg ttcttaattc gcacagtacg     1920

gctgaaacca ctctcgacag cttctttagc agagcggggt tagttggaga gatagacctc     1980

cctcttgaag gtaccactaa cccgaatggt tatgcaaact gggatataga cataacaggt     2040

tacgcgcaaa tgcgcaggaa ggtggagctg ttcacttaca tgcgcttcga cgcagagttc     2100

actttcgtcg cgtgcacgcc taccggggga gttgtcccac agttactcca atatatgttt     2160

gtgccaccag gggctcctaa gccagactcc agagaatccc tcgcatggca aactgccacc     2220

aatccctcag tttttgttaa gttgtcagac cccccagcac aggtttcagt cccattcatg     2280

tcacctgcga gtgcctatca gtggttctat gacggatatc ccacattcgg tgaacacaag     2340

caagagaaag accttgaata cggggcatgt ccaaacaata tgatgggcac gttctcagtg     2400

cggaccgtgg gaacctcgaa gtccaagtac cctttagtta ttagaattta catgaggatg     2460

aagcatatca gggcgtgggt acctcgtcca atgcgcaacc aaaactattt attcaaagct     2520

aacccaaatt atgctggtga ttctattaag ccaaccggtg ccagtcgcac ggcgatcacc     2580

actctt                                                                2586


<210>  86
<211>  7437
<212>  DNA
<213>  Enterovirus 71, strain EV71:TLLeC5

<400>  86
ttaaaacagc ctgtgggttg cacccactca cagggcccac gtggcgctag cactctgatt       60

ctacggaatc tttgtgcgcc tgttttacaa ccccccccaa tttgcaactt agaagcaata      120

cacaacactg atcaacagca ggcatggcgc accagccatg tcttgatcaa gcacttctgt      180

ttccccggac tgagtatcaa tagactgctc acgcggttga aggagaaagc gtccgttatc      240

cggctaacta cttcgagaaa cctagtagca ccattgaaac tgcggagtgt ttcgctcggc      300

acttcccccg tgtagatcag gtcgatgagt cactgcaatc cccacgggcg accgtggcag      360

tggctgcgct ggcggcctgc ctatggggca acccatagga cgctctaatg tggacatggt      420

gcgaagagtc tattgagcta gttagtagtc ctccggcccc tgaatgcggc taatcctaac      480

tgcggagcac atgccctcaa cccagagggt agtgtgtcgt aacgggcaac tctgcagcgg      540

aaccgactac tttgggtgtc cgtgtttcct tttattctta cattggctgc ctatggtgac      600

aatcgcagaa ttgttaccat atagctattg gattggccat ccggtgtgca atagagctat      660

tatataccta tttgttggct ttgtaccatt aaccttaaaa tctataacta ccctcaactt      720

tgtattaact ctcaatacag tcaaacatgg gctcacaagt gtctactcaa cgcgccggct      780

cgcatgaaaa ctctaactca gctactgagg gttctaccat aaactacact accatcaatt      840

actataagga ctcctatgcc gccacagcag gcaaacagag tcttaagcag gatccagaca      900

agtttgcaaa tcctgtcaaa gatattttca ctgaaatggc agccccacta aaatccccat      960

ccgctgaggc atgtgggtac agcgatcgag tagcgcagtt aactatcggc aactccacca     1020

tcactacgca agaagcagca aacattatag ttgggtatgg tgagtggccc tcctactgct     1080

cagattctga cgctacggcg gtggacaaac cgacgcgccc agatgtgtcg gtgaatagat     1140

tctacacatt ggacaccaaa ttgtgggaga aatcgtccaa aggatggtat tggaaattcc     1200

cggatgtgtt aacagaaact ggggtctttg ggcaaaatgc acaattccac tatctctatc     1260

ggtcagggtt ctgcattcac gtgcaatgca atgctagtaa atttcaccaa ggggcgctct     1320

tagtcgctgt cctcccagag tatgtcattg ggacggtggc tggaggcaca ggaacggagg     1380

atagtcaccc cccttatatg caaacccaac ccggcgctga tggttttgag ctgcaacacc     1440

cgtacgtgct tgacgctggt atcccgatat cacaattgac agtgtgccca caccagtgga     1500

ttaatttgag gactaataat tgtgccacaa taatagtgcc gtacataaat gcactaccct     1560

tcgattctgc tttgaaccat tgcaactttg gcctattggt cgtgcctatt agcccgttag     1620

actttgatca aggagcgacg ccggtgatcc ctatcaccat cacattggcc ccaatgtgct     1680

ctgaatttgc gggtcttagg caagcagtca cgcagggatt tcccactgag ctaaaacctg     1740

gcacaaacca atttttaact actgacgacg gtgtttcagc gcccattttg ccaaactttt     1800

accccactcc atgcatccat atacctggtg aagttaggaa tctgttagag ttgtgtcagg     1860

tggagaccat tttagaagtc aataacgtgc ccacgaatgc cactagctta atggagagac     1920

tgcggtttcc ggtctcagcc caagcgggga agggtgagtt gtgtgcagtg ttcagagccg     1980

accctgggcg gagtgggcca tggcagtcta ctttattggg tcagttatgc gggtattaca     2040

ctcaatggtc aggatcactg gaagtcactt tcatgtttac tgggtccttt atggccactg     2100

gcaagatgct tatagcctac acaccgccgg gaggtcccct acccaaggac cgggcgaccg     2160

ccatgttggg tacgcatgtc atctgggatt tcgggctaca atcgtctgtt actcttgtaa     2220

taccatggat tagcaacacc cactacaggg cgcatgctcg agatggagtg ttcgactact     2280

ataccacagg cttggttagt atatggtatc agacgaatta tgtagttcca attggggcac     2340

ccaacacagc ctatataatt gcactagcgg cggcccagaa gaatttcacc atgaagttgt     2400

gcaaagatgc cagtgacatc ctgcagacag gcactatcca gggagacagg gtggcggatg     2460

tgatagaaag ttctataggg gacagcgtga gtagagccct cacccaagcc ctaccggcac     2520

ctacaggcca gaacacgcag gtaagcagcc accgactaga cactggtaaa gtcccagcgc     2580

ttcaagccgc tgagattgga gcatcgtcaa acgctagcga tgagagcatg attgagacac     2640

ggtgtgttct taattcgcac agtacggctg aaaccactct cgacagcttc tttagcagag     2700

cggggttagt tggagagata gacctccctc ttgaaggtac cactaacccg aatggttatg     2760

caaactggga tatagacata acaggttacg cgcaaatgcg caggaaggtg gagctgttca     2820

cttacatgcg cttcgacgca gagttcactt tcgtcgcgtg cacgcctacc gggggagttg     2880

tcccacagtt actccaatat atgtttgtgc caccaggggc tcctaagcca gactccagag     2940

aatccctcgc atggcaaact gccaccaatc cctcagtttt tgttaagttg tcagaccccc     3000

cagcacaggt ttcagtccca ttcatgtcac ctgcgagtgc ctatcagtgg ttctatgacg     3060

gatatcccac attcggtgaa cacaagcaag agaaagacct tgaatacggg gcatgtccaa     3120

acaatatgat gggcacgttc tcagtgcgga ccgtgggaac ctcgaagtcc aagtaccctt     3180

tagttattag aatttacatg aggatgaagc atatcagggc gtgggtacct cgtccaatgc     3240

gcaaccaaaa ctatttattc aaagctaacc caaattatgc tggtgattct attaagccaa     3300

ccggtgccag tcgcacgacg atcaccactc ttgggaaatt cggccggcaa tctggggcca     3360

tatacgtggg caacttcaga gtggttaatc gtcacctcgc tactcataat gactgggcga     3420

attccgtctg ggaggacagc tcccgcgacc tactagtgtc gtctactact gcccagggct     3480

gtgatacaat tgcacgttgt gactgtcaaa caggagtgta ctattgtaac tctaagagaa     3540

agcactatcc agtcagcttc tctaaaccta gcctcactta tgtggaagct agcgagtatt     3600

accctgctag ataccagtct catctcatgc ttgcggcggg tcattctgaa ccaggagatt     3660

gtggtggcat ccttaggtgc cagcacggtg ttgtcggcat tgtgtccact ggtggcaacg     3720

ggcttgttgg ctttgcagat gtcagggatc tcctatggtt ggatgaagaa gcaatggagc     3780

agggtgtgtc cgactacatt aagggacttg gtgatgcgtt tggaactggc ttcaccgatg     3840

cagtttccag agaagttgag gctcttaaga gccaccttat tgggtctgaa ggagttgtcg     3900

agaagatcct aaagaatttg atcaaattaa tctctgcttt agtcatcgtg attaggagtg     3960

attatgacat ggtcactctc acagcaactt tagctctgat agggtgccac ggtagtccct     4020

gggcatggat taaagcaaaa acagcttcca ttctaggcat ccctattgcc cagaagcaaa     4080

gtgcgtcctg gcttaaaaaa tttaacgata tggccaacgc cgccaagggg ttagagtgga     4140

tctccagtaa gattagtaaa ttcatcgatt ggctcaaaga gaaaatcata ccagcggcta     4200

gggagaaggt ggagtttctg aacaacttaa aacagttgcc gttgctggag aatcagatct     4260

caaatctaga gcagtctgct gcttcacaag aaaatctcga agccatgttc ggaaatgtgt     4320

cgtacctagc tcacttctgc cgcaaattcc aaccactgta cgctacagaa gccaaaaggg     4380

tctatgcttt ggagaaaaga atgaacaact acatgcagtt caagagcaaa caccgaattg     4440

aacctgtatg tcttattatt aggggttctc cgggcaccgg gaaatcacta gcaactggca     4500

tcattgctcg ggcaatagca gacaagtatc actcaagtgt gtactcactc ccaccagacc     4560

cggaccactt tgatggatac aaacagcagg tggtcacggt catggatgac ttatgtcaga     4620

accctgacgg caaagatatg tcattgttct gccagatggt gtccacagtg gatttcatcc     4680

caccaatggc ttccctagaa gagaaaggag tttctttcac atctaaattt gtcattgcat     4740

ctactaattc cagcaacatc atagtaccaa cagtgtctga ttctgatgca attcgccgta     4800

ggttctatat ggattgtgat atcgaagtca cggattcata caaaacggac ttgggtaggt     4860

tagatgctgg gcgagccgcc aaattgtgct ctgagaataa cacagcaaat ttcaagcgtt     4920

gtagcccact agtgtgtggg aaggccattc agctgagaga tagaaagtcc aaggtcaggt     4980

acagtgtgga cacggtggtt tctgagctca taagggaata caacaacagg tctgctatcg     5040

gtatcacaat tgaagcacta ttccaaggtc cgcctaagtt taaacccata aggattagtc     5100

ttgaagaaaa gccagcccca gacgccatta gtgaccttct tgctagtgtg gatagcgagg     5160

aggtacgcca gtactgtaga gatcaaggtt ggatcattcc agagactcct acaaatgttg     5220

aacggcacct caacagagct gtgctagtca tgcaatccat cactacagtt gtggcagtcg     5280

tttcactggt gtacgtcatc tacaagctct tcgctggatt ccaaggcgcg tactctggtg     5340

ctcccaagca gatactcaag aaacccgttc tccgcacggc aacagtgcag ggtccaagtc     5400

tcgatttcgc tctgtctcta ctaaggagga atatcaggca agtgcaaaca gatcaaggac     5460

attttaccat gctgggtgtc agggaccgtt tggctgttct tccacgccac tcccagcccg     5520

gcaaaacaat ctgggtagag cacaaactcg taaacattct ggacgctgtt gaactggtgg     5580

atgaacaagg ggtcaatttg gagctaaccc taatcaccct tgacactaat gagaaattca     5640

gagacattac taagttcatc ccggagagca tcagcactgc aagcgatgct accctagtga     5700

tcaacacaga gcacatgccc tcaatgtttg tgccggtggg ggacgttgtg caatatggtt     5760

ttctcaacct tagtggaaag ccaacccacc gtaccatgat gtacaacttt cccaccaagg     5820

cagggcagtg tggaggggtg gtgacatcag ttggaaaggt cattggtata cacataggtg     5880

gtaacggcag acaaggtttc tgtgcgggac ttaagaggag ctatttcgcc agcgagcaag     5940

gagagatcca gtgggtcaag cccaataaag aaactgggag actcaacatc aatgggccaa     6000

ctcgcactaa gctcgaaccc agtgtatttc atgatgtttt tgagggaaac aaggagccag     6060

cagttctaca cagtaaagat ccccgcctcg aggtggattt tgagcaggct ttgttctcca     6120

agtacgtagg gaatacacta tatgagcctg atgattacat taaggaggca gctcttcact     6180

acgcaaatca gttgaaacag ctggacattg acacctccca gatgagcatg gaggaagcct     6240

gttacggcac tgagaacctt gaggccattg atcttcacac tagtgcaggt tacccataca     6300

gtgctctagg aataaagaaa agagacatcc tagattctac tactagggat gtgagcaaga     6360

tgaaatttta tatggacaag tatggcttgg acctacccta ctccacctat gtcaaggatg     6420

agctacgctc gatagataag atcaagaaag ggaagtctcg tttgattgaa gccagcagct     6480

taaatgattc tgtgtacctt aggatgactt ttgggcacct ttatgaaacc ttccatgcaa     6540

accctggaac tgtgaccggt tcagccgtgg gatgcaatcc ggatacattc tggagtaaac     6600

tacccatctt actccctggc tcactctttg ctttcgacta ttcaggatat gatgctagtc     6660

ttagccctgt ctggttcagg gcattagaat tagttcttag ggaaataggc tacagtgagg     6720

aagcagtttc acttgttgag gggatcaatc acacgcacca tgtataccgc aacaaaactt     6780

actgtgtgct tggtggcatg ccctctggtt gctcaggaac atccatattc aattcaatga     6840

tcaataacat tattattaga gcactgctca tcaaaacgtt caagggcatt gatttagacg     6900

agctcaacat ggttgcctat ggggatgatg tgcttgccag ttaccctttt ccaattgact     6960

gcttggagtt ggcaagaaca ggcaaggagt acggtttaac catgactcct gcagacaaat     7020

ccccatgctt caatgaagtc aattgggata acgcaacctt tctcaaaaga ggcttcttgc     7080

ccgatgaaca atttccattc cttatccacc ctaccatgcc aatgaaagaa atccacgagt     7140

ccatacggtg gaccaaggac gcgcgaaata cccaagatca cgtgcggtcc ttgtgccttc     7200

tggcatggca caatggtaaa caggaatatg aaaagtttgt gagcgcaatt agatcagtac     7260

cagtaggaaa agtattggct attccaaatt atgagaatct gagacgcaat tggctcgaac     7320

tattttagag gttaagtata tacctcaacc ccaccaggaa tctggtcgtg aacatgactg     7380

gtgggggtaa atttgttatt accagaatag caaaaaaaaa aaaaaaaaaa aaaaaaa        7437


<210>  87
<211>  2586
<212>  DNA
<213>  Coxsackievirus A16

<400>  87
atggggtcac aagtctccac tcagcgatcc gggtcacatg agaactcaaa ctctgcatcg       60

gaaggctcga ccataaatta cacaactata aactactaca aggatgcata cgctgcgagt      120

gcagggcgcc aggatatgtc ccaagacccg aagaaattta ccgaccctgt catggacgtt      180

atacatgaga tggctccacc gctcaagtct ccaagcgctg aggcatgtgg ttatagtgat      240

cgtgtggctc aacttaccat tggaaactct accatcacga cacaggaagc agctaacata      300

gttatagcct atggggagtg gcctgagtac tgcccagaca cagatgcaac ggcagtcgac      360

aaacccacac gacccgacgt gtcagtgaac agatttttca cgctagacac taaatcttgg      420

gccaaggatt caaagggatg gtattggaaa ttccctgatg ttttgacaga agtaggtgtt      480

tttggtcaaa acgctcagtt ccactacctg tatcgatctg gattttgcgt gcacgttcag      540

tgtaatgcaa gtaaattcca ccagggcgct ttactggtgg ctgtgctgcc tgagtatgtg      600

ctcggcacta tcgcaggagg gaccggggat gagaatactc atcctcccta cgccactaca      660

cagcctggtc aggttggtgc agtcctgacg cacccttacg tgctagatgc agggatccct      720

ttgagccaat tacctgtgtg cccacatcag tggatcaacc tgagaaccaa taattgtgca      780

accattatag ttccatatat gaacacagtt ccatttgact cagctctcaa ccactgcaat      840

tttggtctac tggtcatccc ggtagtacca ttggatttca atgcaggcgc cacatctgaa      900

attcccatta cagtcaccat agcccccatg tgtgcggaat ttgcgggtct gcgccaggca      960

gtaaagcaag gcataccaac agagcttaaa cctggcacca atcagttcct tactaccgat     1020

gatggtgttt ctgcaccaat tttgccaggt ttccacccaa ctccacctat acacatacca     1080

ggggaagtac acaacctatt ggaaatatgc agagtggaga ccatcttgga ggttaacaac     1140

ctgaagacca atgagaccac ccccatgcag cgcttgtgct ttccagtgtc ggtgcagagc     1200

aaaacgggcg agttatgtgc tgcctttaga gcagaccctg gaagagatgg tccgtggcag     1260

tccacaatac tgggccaact ctgcaggtac tacacccagt ggtcaggttc attggaggtg     1320

acattcatgt ttgcgggctc attcatggct acaggtaaga tgctcatcgc ctacacccca     1380

cctgggggaa atgcgcctgt ggacagaatc acagcaatgc taggaacgca tgtgatctgg     1440

gacttcggat tacagtcttc tgtgacgttg gtcgtgccat ggattagtaa cacacactat     1500

agggcacacg cccgtgctgg gtactttgac tattacacca ctggcattat aaccatatgg     1560

tatcaaacta actatgtagt acccattggt gctcccacta cagcatacat cgtagctttg     1620

gcagcagccc aggacaactt caccatgaaa ctatgcaagg acacagagga cattgagcaa     1680

acagctaata tacaagggga tcctattgca gacatgattg accagactgt gaataatcaa     1740

gtgaaccgct ccttaactgc attgcaagta ctacctacag ctgccaatac tgaagcaagt     1800

agtcacagat taggcactgg tgttgtacca gcactacaag ccgcggagac aggggcgtcg     1860

tcaaatgcta gtgacaagaa tctcattgag actagatgtg tgttgaacca tcactccaca     1920

caggagacag ccattgggaa tttctttagc cgtgccggtt tggttagcat tattacaatg     1980

cccaccacag gtacacagaa cacagatggt tacgttaact ggggcattga tttgatggga     2040

tatgctcaac tgcggcggaa gtgcgagttg tttacctaca tgcgctttga tgctgaattc     2100

acatttgtcg tagccaaacc caatggtgag ctagtccccc aattactgca gtacatgtat     2160

gtcccgccag gggctccgaa acccacttcc agagattcat ttgcctggca aactgctacc     2220

aacccatctg tgtttgtgaa aatgacggac ccaccagctc aagtgtcagt ccccttcatg     2280

tcaccagcca gtgcatacca atggttttat gatggttatc ccaccttcgg agagcatctc     2340

caagcagatg acctagatta tggtcaatgc ccgaataata tgatgggcac ttttagcatt     2400

aggacagtag ggactgagaa gtcaccacac tccatcaccc tgagggtata catgaggatt     2460

aaacacgtca gggcatggat cccaaggcct ttgagaaatc aaccctattt gtttaagacc     2520

aatccaaatt ataaaggaaa tgatattaag tgcactagca ctagtagaga caagataaca     2580

acattg                                                                2586


<210>  88
<211>  7439
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric virus strain TLLeCA16

<400>  88
ttaaaacagc ctgtgggttg cacccactca cagggcccac gtggcgctag cactctgatt       60

ctacggaatc tttgtgcgcc tgttttacaa ccccccccaa tttgcaactt agaagcaata      120

cacaacactg atcaacagca ggcatggcgc accagccatg tcttgatcaa gcacttctgt      180

ttccccggac tgagtatcaa tagactgctc acgcggttga aggagaaagc gtccgttatc      240

cggctaacta cttcgagaaa cctagtagca ccattgaaac tgcggagtgt ttcgctcggc      300

acttcccccg tgtagatcag gtcgatgagt cactgcaatc cccacgggcg accgtggcag      360

tggctgcgct ggcggcctgc ctatggggca acccatagga cgctctaatg tggacatggt      420

gcgaagagtc tattgagcta gttagtagtc ctccggcccc tgaatgcggc taatcctaac      480

tgcggagcac atgccctcaa cccagagggt agtgtgtcgt aacgggcaac tctgcagcgg      540

aaccgactac tttgggtgtc cgtgtttcct tttattctta cattggctgc ctatggtgac      600

aatcgcagaa ttgttaccat atagctattg gattggccat ccggtgtgca atagagctat      660

tatataccta tttgttggct ttgtaccatt aaccttaaaa tctataacta ccctcaactt      720

tgtattaact ctcaatacag tcaaacatgg gctcacaagt gtctactcaa cgcgtcgggt      780

cacatgagaa ctcaaactct gcatcggaag gctcgaccat aaattacaca actataaact      840

actacaagga tgcatacgct gcgagtgcag ggcgccagga tatgtcccaa gacccgaaga      900

aatttaccga ccctgtcatg gacgttatac atgagatggc tccaccgctc aagtctccaa      960

gcgctgaggc atgtggttat agtgatcgtg tggctcaact taccattgga aactctacca     1020

tcacgacaca ggaagcagct aacatagtta tagcctatgg ggagtggcct gagtactgcc     1080

cagacacaga tgcaacggca gtcgacaaac ccacacgacc cgacgtgtca gtgaacagat     1140

ttttcacgct agacactaaa tcttgggcca aggattcaaa gggatggtat tggaaattcc     1200

ctgatgtttt ggcagaagta ggtgtttttg gtcaaaacgc tcagttccac tacctgtatc     1260

gatctggatt ttgcgtgcac gttcagtgta atgcaagtaa attccaccag ggcgctttac     1320

tggtggctgt gctgcctgag tatgtgctcg gcactatcgc aggagggacc ggggatgaga     1380

atactcatcc tccctacgcc actacacagc ctggtcaggt tggtgcagtc ctgacgcacc     1440

cttacgtgct agatgcaggg atccctttga gccaattacc tgtgtgccca catcagtgga     1500

tcaacctgag aaccaataat tgtgcaacca ttatagttcc atatatgaac acagttccat     1560

ttgactcagc tctcaaccac tgcaattttg gtctactggt catcccggta gtaccattgg     1620

atttcaatgc aggcgccaca tctgaaattc ccattacagt caccatagcc cccatgtgtg     1680

cggaatttgc gggtctgcgc caggcagtaa agcaaggcat accaacagag cttaaacctg     1740

gcaccaatca gttccttact accgatgatg gtgtttctgc accaattttg ccaggtttcc     1800

acccaactcc acctatacac ataccagggg aagtacacaa cctattggaa atatgcagag     1860

tggagaccat cttggaggtt aacaacctga agaccaatga gaccaccccc atgcagcgct     1920

tgtgctttcc agtgtcggtg cagagcaaaa cgggcgagtt atgtgctgcc tttagagcag     1980

accctggaag agatggtccg tggcagtcca caatactggg ccaactctgc aggtactaca     2040

cccagtggtc aggttcattg gaggtgacat tcatgtttgc gggctcattc atggctacag     2100

gtaagatgct catcgcctac accccacctg ggggaaatgt gcctgtggac agaatcacag     2160

caatgctagg aacgcatgtg atctgggact tcggattaca gtcttctgtg acgttggtcg     2220

tgccatggat tagtaacaca cactataggg cacacgcccg tgctgggtac tttgactatt     2280

acaccactgg cattataacc atatggtatc aaactaacta tgtagtaccc attggtgctc     2340

ccactacagc atacatcgta gctttggcag cagcccagga caacttcacc atgaaactat     2400

gcaaagacac agaggacatt gagcaaacag ctaatataca aggggatcct attgcagaca     2460

tgattgacca gactgtgaat aatcaagtga accgctcctt aactgcattg caagtactac     2520

ctacagctgc caatactgaa gcaagtagtc acagattagg cactggtgtt gtaccagcac     2580

tacaagccgc ggagacaggg gcgtcgtcaa atgctagtga caagaatctc attgagacta     2640

gatgtgtgtt gaaccatcac tccacacagg agacagccat tgggaatttc tttagccgtg     2700

ccggtttggt tagcattatt acaatgccca ccacaggtac acagaacaca gatggttacg     2760

ttaactgggg cattgatttg atgggatatg ctcaactgcg gcggaagtgc gagttgttta     2820

cctacatgcg ctttgatgct gaattcacat ttgtcgtagc caaacccaat ggtgagctag     2880

tcccccaatt actgcagtac atgtatgtcc cgccaggggc tccgaaaccc acttccagag     2940

attcattcgc ctggcaaact gctaccaacc catctgtgtt tgtgaaaatg acggacccac     3000

cagctcaagt gtcagtcccc ttcatgtcac cagccagtgc ataccaatgg ttttatgatg     3060

gttatcccac cttcggagag catctccaag cagatgacct agattatggt caatgcccga     3120

ataatatgat gggcactttt agcattagga cagtagggac tgagaagtca ccacactcca     3180

tcaccctgag ggtatacatg aggattaaac acgtcagggc atggatccca aggcctctga     3240

gaaatcaacc ctatttgttt aagaccaatc caaattataa aggaaatgat attaagtgca     3300

ctagcactag tagagacacg ataacaacat tgggagagtt cggccagcaa tctggggcca     3360

tttacgtggg caacttcaga gtggttaatc gtcacctcgc tactcataat gactgggcga     3420

attgcgtctg ggaggacagc tcccgcgacc tactagtgtc gtctactact gcccagggct     3480

gtgatacaat tgcacgttgt gactgtcaaa caggagtgta ctattgtaac tctaagagaa     3540

agcactatcc agtcagcttc tctaaaccta gcctcactta tgtggaagct agcgagtatt     3600

accctgctag ataccagtct catctcatgc ttgcggcggg tcattctgaa ccaggagatt     3660

gtggtggcat ccttaggtgc cagcacggtg ttgtcggcat tgtgtccact ggtggcaacg     3720

ggcttgttgg ctttgcagat gtcagggatc tcctatggtt ggatgaagaa gcaatggagc     3780

agggtgtgtc cgactacatt aagggacttg gtgatgcgtt tggaactggc ttcaccgatg     3840

cagtttccag agaagttgag gctcttaaga gccaccttat tgggtctgaa ggagttgtcg     3900

agaagatcct aaagaatttg atcaaattaa tctctgcttt agtcatcgtg attaggagtg     3960

attatgacat ggtcactctc acagcaactt tagctctgat agggtgccac ggtagtccct     4020

gggcatggat taaagcaaaa acagcttcca ttctaggcat ccctattgcc cagaagcaaa     4080

gtgcgtcctg gcttaaaaaa tttaacgata tggccaacgc cgccaagggg ttagagtgga     4140

tctccagtaa gattagtaaa ttcatcgatt ggctcaaaga gaaaatcata ccagcggcta     4200

gggagaaggt ggagtttctg aacaacttaa aacagttgcc gttgctggag aatcagatct     4260

caaatctaga gcagtctgct gcttcacaag aaaatctcga agccatgttc ggaaatgtgt     4320

cgtacctagc tcacttctgc cgcaaattcc aaccactgta cgctacagaa gccaaaaggg     4380

tctatgcttt ggagaaaaga atgaacaact acatgcagtt caagagcaaa caccgaattg     4440

aacctgtatg tcttattatt aggggttctc cgggcaccgg gaaatcacta gcaactggca     4500

tcattgctcg ggcaatagca gacaagtatc actcaagtgt gtactcactc ccaccagacc     4560

cggaccactt tgatggatac aaacagcagg tggtcacggt catggatgac ttatgtcaga     4620

accctgacgg caaagatatg tcattgttct gccagatggt gtccacagtg gatttcatcc     4680

caccaatggc ttccctagaa gagaaaggag tttctttcac atctaaattt gtcattgcat     4740

ctactaattc cagcaacatc atagtaccaa cagtgtctga ttctgatgca attcgccgta     4800

ggttctatat ggattgtgat atcgaagtca cggattcata caaaacggac ttgggtaggt     4860

tagatgctgg gcgagccgcc aaattgtgct ctgagaataa cacagcaaat ttcaagcgtt     4920

gtagcccact agtgtgtggg aaggccattc agctgagaga tagaaagtcc aaggtcaggt     4980

acagtgtgga cacggtggtt tctgagctca taagggaata caacaacagg tctgctatcg     5040

gtaacacaat tgaagcacta ttccaaggtc cgcctaagtt taaacccata aggattagtc     5100

ttgaagaaaa gccagcccca gacgccatta gtgaccttct tgctagtgtg gatagcgagg     5160

aggtacgcca gtactgtaga gatcaaggtt ggatcattcc agagactcct acaaatgttg     5220

aacggcacct caacagagct gtgctagtca tgcaatccat cactacagtt gtggcagtcg     5280

tttcactggt gtacgtcatc tacaagctct tcgctggatt ccaaggcgcg tactctggtg     5340

ctcccaagca gatactcaag aaacccgttc tccgcacggc aacagtgcag ggtccaagtc     5400

tcgatttcgc tctgtctcta ctaaggagga atatcaggca agtgcaaaca gatcaaggac     5460

attttaccat gctgggtgtc agggaccgtt tggctgttct tccacgccac tcccagcccg     5520

gcaaaacaat ctgggtagag cacaaactcg taaacattct ggacgctgtt gaactggtgg     5580

atgaacaagg ggtcaatttg gagctaaccc taatcaccct tgacactaat gagaaattca     5640

gagacattac taagttcatc ccggagagca tcagcactgc aagcgatgct accctagtga     5700

tcaacacaga gcacatgccc tcaatgtttg tgccggtggg ggacgttgtg caatatggtt     5760

ttctcaacct tagtggaaag ccaacccacc gtaccatgat gtacaacttt cccaccaagg     5820

cagggcagtg tggaggggtg gtgacatcag ttggaaaggt cattggtata cacataggtg     5880

gtaacggcag acaaggtttc tgtgcgggac ttaagaggag ctatttcgcc agcgagcaag     5940

gagagatcca gtgggtcaag cccaataaag aaactgggag actcaacatc aatgggccaa     6000

ctcgcactaa gctcgaaccc agtgtatttc atgatgtttt tgagggaaac aaggagccag     6060

cagttctaca cagtaaagat ccccgcctcg aggtggattt tgagcaggct ttgttctcca     6120

agtacgtagg gaatacacta tatgagcctg atgattacat taaggaggca gctcttcact     6180

acgcaaatca gttgaaacag ctggacattg acacctccca gatgagcatg gaggaagcct     6240

gttacggcac tgagaacctt gaggccattg atcttcacac tagtgcaggt tacccataca     6300

gtgctctagg aataaagaaa agagacatcc tagattctac tactagggat gtgagcaaga     6360

tgaaatttta tatggacaag tatggcttgg acctacccta ctccacctat gtcaaggatg     6420

agctacgctc gatagataag atcaagaaag ggaagtctcg tttgattgaa gccagcagct     6480

taaatgattc tgtgtacctt aggatgactt ttgggcacct ttatgaaacc ttccatgcaa     6540

accctggaac tgtgaccggt tcagccgtgg gatgcaatcc ggatacattc tggagtaaac     6600

tacccatctt actccctggc tcactctttg ctttcgacta ttcaggatat gatgctagtc     6660

ttagccctgt ctggttcagg gcattagaat tagttcttag ggaaataggc tacagtgagg     6720

aagcagtttc acttgttgag gggatcaatc acacgcacca tgtataccgc aacaaaactt     6780

actgtgtgct tggtggcatg ccctctggtt gctcaggaac atccatattc aattcaatga     6840

tcaataacat tattattaga gcactgctca tcaaaacgtt caagggcatt gatttagacg     6900

agctcaacat ggttgcctat ggggatgatg tgcttgccag ttaccctttt ccaattgact     6960

gcttggagtt ggcaagaaca ggcaaggagt acggtttaac catgactcct gcagacaaat     7020

ccccatgctt caatgaagtc aattgggata acgcaacctt tctcaaaaga ggcttcttgc     7080

ccgatgaaca atttccattc cttatccacc ctaccatgcc aatgaaagaa atccacgagt     7140

ccatacggtg gaccaaggac gcgcgaaata cccaagatca cgtgcggtcc ttgtgccttc     7200

tggcatggca caatggtaaa caggaatatg aaaagtttgt gagcgcaatt agatcagtac     7260

cagtaggaaa agtattggct attccaaatt atgagaatct gagacgcaat tggctcgaac     7320

tattttagag gttaagtata tacctcaacc ccaccaggaa tctggtcgtg aacatgactg     7380

gtgggggtaa atttgttatt accagaatag caaaaaaaaa aaaaaaaaaa aaaaaaaaa      7439


