SEQUENCE LISTING

<110>  GILEAD BIOLOGICS, Inc.
       Fan, Peidong
       Yao, Lina
       Kang, Jong
 
<120>  METHODS FOR TREATING CARDIOVASCULAR DISEASES

<130>  1068.PF

<150>  US 62/010,929
<151>  2014-06-11

<160>  51

<170>  PatentIn version 3.5                               

<210> 1
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide

<400> 1
Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
1               5                   10                  15      


<210> 2
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 2
Asp Thr Tyr Glu Arg Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly 
1               5                   10                  15  


<210> 3
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 3
Arg Arg Leu Leu Arg Phe Ser Ser Gln Ile His Asn Asn Gly Gln Ser 
1               5                   10                  15      


Asp Phe Arg Pro Lys Asn Gly Arg 
            20                  


<210> 4
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 4
Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg Arg Phe Ala 
1               5                   10                  


<210> 5
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 5
Glu Asp Thr Glu Cys Glu Gly Asp Ile Gln Lys Asn Tyr Glu 
1               5                   10                  


<210> 6
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 6
Asp Pro Tyr Tyr Ile Gln Ala Ser Thr Tyr Val Gln Lys Met Ser Met 
1               5                   10                  15      


Tyr Asn Leu Arg Cys 
            20      


<210> 7
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 7
Asn Ala Glu Met Val Gln Gln Thr Thr Tyr Leu Glu Asp Arg Pro Met 
1               5                   10                  15      


Phe Met Leu Gln Cys 
            20      


<210> 8
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 8
Gly Ser Gln Tyr Gly Pro Gly Arg Arg Arg Asp Pro Gly Ala 
1               5                   10                  


<210> 9
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 9
Trp Glu Trp His Ser Cys His Gln His Tyr His 
1               5                   10      


<210> 10
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 10
Trp Glu Trp His Ser Cys His Gln His Tyr His 
1               5                   10      


<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 11
Trp Ile Trp His Asp Cys His Arg His Tyr His 
1               5                   10      


<210> 12
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 12
Trp Val Trp His Glu Cys His Gly His Tyr His 
1               5                   10      


<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 13
Trp Val Trp His Gln Cys His Arg His Tyr His 
1               5                   10      


<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 14
Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val Lys Pro Gly Asn 
1               5                   10                  15      


Tyr 
    


<210> 15
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 15
Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val Gln Pro Gly Asn 
1               5                   10                  15      


Tyr 
    


<210> 16
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 16
Asp Ile Asp Cys Gln Trp Val Asp Ile Thr Asp Val Pro Pro Gly Asp 
1               5                   10                  15      


Tyr 
    


<210> 17
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 17
Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val Lys Pro Gly Asn 
1               5                   10                  15      


Tyr 
    


<210> 18
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 18
Asp Ile Asp Cys Gln Trp Val Asp Ile Thr Asp Val Gly Pro Gly Asn 
1               5                   10                  15      


Tyr 

    
<210> 19
<211> 417
<212> PRT
<213> Homo sapiens

<400> 19
Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys 
1               5                   10                  15      
Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
            20                  25                  30          
Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
        35                  40                  45              
Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
    50                  55                  60                  
Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
65                  70                  75                  80  
Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
                85                  90                  95      
Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
            100                 105                 110         
Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
        115                 120                 125             
Tyr Ser Thr Ser Arg Ala Arg Glu Ala Gly Ala Ser Arg Ala Glu Asn 
    130                 135                 140                 
Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
145                 150                 155                 160 
Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
                165                 170                 175     
Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
            180                 185                 190         
Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
        195                 200                 205             
Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
    210                 215                 220                 
Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
225                 230                 235                 240 
Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
                245                 250                 255     
Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
            260                 265                 270         
Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
        275                 280                 285             
His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr 
    290                 295                 300                 
Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys 
305                 310                 315                 320 
Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
                325                 330                 335     
Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr 
            340                 345                 350         
Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp 
        355                 360                 365             
Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr 
    370                 375                 380                 
Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile 
385                 390                 395                 400 
Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro 
                405                 410                 415     
Tyr 
    


<210> 20
<211> 401
<212> PRT
<213> Homo sapiens

<400> 20
Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
1               5                   10                  15      
Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
            20                  25                  30          
Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
        35                  40                  45              
Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
    50                  55                  60                  
Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
65                  70                  75                  80  
Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
                85                  90                  95      
Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
            100                 105                 110         
Tyr Ser Thr Ser Arg Ala Arg Glu Ala Gly Ala Ser Arg Ala Glu Asn 
        115                 120                 125             
Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
    130                 135                 140                 
Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
145                 150                 155                 160 
Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
                165                 170                 175     
Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
            180                 185                 190         
Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
        195                 200                 205             
Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
    210                 215                 220                 
Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
225                 230                 235                 240 
Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
                245                 250                 255     
Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
            260                 265                 270         
His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr 
        275                 280                 285             
Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys 
    290                 295                 300                 
Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
305                 310                 315                 320 
Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr 
                325                 330                 335     
Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp 
            340                 345                 350         
Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr 
        355                 360                 365             
Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile 
    370                 375                 380                 
Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro 
385                 390                 395                 400 
Tyr 
    


<210> 21
<211> 249
<212> PRT
<213> Homo sapiens

<400> 21
Asp Asp Pro Tyr Asn Pro Tyr Lys Tyr Ser Asp Asp Asn Pro Tyr Tyr 
1               5                   10                  15      
Asn Tyr Tyr Asp Thr Tyr Glu Arg Pro Arg Pro Gly Gly Arg Tyr Arg 
            20                  25                  30          
Pro Gly Tyr Gly Thr Gly Tyr Phe Gln Tyr Gly Leu Pro Asp Leu Val 
        35                  40                  45              
Ala Asp Pro Tyr Tyr Ile Gln Ala Ser Thr Tyr Val Gln Lys Met Ser 
    50                  55                  60                  
Met Tyr Asn Leu Arg Cys Ala Ala Glu Glu Asn Cys Leu Ala Ser Thr 
65                  70                  75                  80  
Ala Tyr Arg Ala Asp Val Arg Asp Tyr Asp His Arg Val Leu Leu Arg 
                85                  90                  95      
Phe Pro Gln Arg Val Lys Asn Gln Gly Thr Ser Asp Phe Leu Pro Ser 
            100                 105                 110         
Arg Pro Arg Tyr Ser Trp Glu Trp His Ser Cys His Gln His Tyr His 
        115                 120                 125             
Ser Met Asp Glu Phe Ser His Tyr Asp Leu Leu Asp Ala Asn Thr Gln 
    130                 135                 140                 
Arg Arg Val Ala Glu Gly His Lys Ala Ser Phe Cys Leu Glu Asp Thr 
145                 150                 155                 160 
Ser Cys Asp Tyr Gly Tyr His Arg Arg Phe Ala Cys Thr Ala His Thr 
                165                 170                 175     
Gln Gly Leu Ser Pro Gly Cys Tyr Asp Thr Tyr Gly Ala Asp Ile Asp 
            180                 185                 190         
Cys Gln Trp Ile Asp Ile Thr Asp Val Lys Pro Gly Asn Tyr Ile Leu 
        195                 200                 205             
Lys Val Ser Val Asn Pro Ser Tyr Leu Val Pro Glu Ser Asp Tyr Thr 
    210                 215                 220                 
Asn Asn Val Val Arg Cys Asp Ile Arg Tyr Thr Gly His His Ala Tyr 
225                 230                 235                 240 
Ala Ser Gly Cys Thr Ile Ser Pro Tyr 
                245                 

<210> 22
<211> 774
<212> PRT
<213> Homo sapiens

<400> 22
Met Glu Arg Pro Leu Cys Ser His Leu Cys Ser Cys Leu Ala Met Leu
 1               5                  10                  15      
Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp Pro His
            20                  25                  30          
Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln Pro Gln
        35                  40                  45              
Ala Pro Ala Asn Val Ala Lys Ile Gln Leu Arg Leu Ala Gly Gln Lys
    50                  55                  60                  
Arg Lys His Ser Glu Gly Arg Val Glu Val Tyr Tyr Asp Gly Gln Trp
65                  70                  75                  80  
Gly Thr Val Cys Asp Asp Asp Phe Ser Ile His Ala Ala His Val Val
                85                  90                  95      
Cys Arg Glu Leu Gly Tyr Val Glu Ala Lys Ser Trp Thr Ala Ser Ser
            100                 105                 110         
Ser Tyr Gly Lys Gly Glu Gly Pro Ile Trp Leu Asp Asn Leu His Cys
        115                 120                 125             
Thr Gly Asn Glu Ala Thr Leu Ala Ala Cys Thr Ser Asn Gly Trp Gly
    130                 135                 140                 
Val Thr Asp Cys Lys His Thr Glu Asp Val Gly Val Val Cys Ser Asp
145                 150                 155                 160 
Lys Arg Ile Pro Gly Phe Lys Phe Asp Asn Ser Leu Ile Asn Gln Ile
                165                 170                 175     
Glu Asn Leu Asn Ile Gln Val Glu Asp Ile Arg Ile Arg Ala Ile Leu
            180                 185                 190         
Ser Thr Tyr Arg Lys Arg Thr Pro Val Met Glu Gly Tyr Val Glu Val
        195                 200                 205             
Lys Glu Gly Lys Thr Trp Lys Gln Ile Cys Asp Lys His Trp Thr Ala
    210                 215                 220                 
Lys Asn Ser Arg Val Val Cys Gly Met Phe Gly Phe Pro Gly Glu Arg
225                 230                 235                 240 
Thr Tyr Asn Thr Lys Val Tyr Lys Met Phe Ala Ser Arg Arg Lys Gln
                245                 250                 255     
Arg Tyr Trp Pro Phe Ser Met Asp Cys Thr Gly Thr Glu Ala His Ile
            260                 265                 270         
Ser Ser Cys Lys Leu Gly Pro Gln Val Ser Leu Asp Pro Met Lys Asn
        275                 280                 285             
Val Thr Cys Glu Asn Gly Leu Pro Ala Val Val Ser Cys Val Pro Gly
    290                 295                 300                 
Gln Val Phe Ser Pro Asp Gly Pro Ser Arg Phe Arg Lys Ala Tyr Lys
305                 310                 315                 320 
Pro Glu Gln Pro Leu Val Arg Leu Arg Gly Gly Ala Tyr Ile Gly Glu
                325                 330                 335     
Gly Arg Val Glu Val Leu Lys Asn Gly Glu Trp Gly Thr Val Cys Asp
            340                 345                 350         
Asp Lys Trp Asp Leu Val Ser Ala Ser Val Val Cys Arg Glu Leu Gly
        355                 360                 365             
Phe Gly Ser Ala Lys Glu Ala Val Thr Gly Ser Arg Leu Gly Gln Gly
    370                 375                 380                 
Ile Gly Pro Ile His Leu Asn Glu Ile Gln Cys Thr Gly Asn Glu Lys
385                 390                 395                 400 
Ser Ile Ile Asp Cys Lys Phe Asn Ala Glu Ser Gln Gly Cys Asn His
                405                 410                 415     
Glu Glu Asp Ala Gly Val Arg Cys Asn Thr Pro Ala Met Gly Leu Gln
            420                 425                 430         
Lys Lys Leu Arg Leu Asn Gly Gly Arg Asn Pro Tyr Glu Gly Arg Val
        435                 440                 445             
Glu Val Leu Val Glu Arg Asn Gly Ser Leu Val Trp Gly Met Val Cys
    450                 455                 460                 
Gly Gln Asn Trp Gly Ile Val Glu Ala Met Val Val Cys Arg Gln Leu
465                 470                 475                 480 
Gly Leu Gly Phe Ala Ser Asn Ala Phe Gln Glu Thr Trp Tyr Trp His
                485                 490                 495     
Gly Asp Val Asn Ser Asn Lys Val Val Met Ser Gly Val Lys Cys Ser
            500                 505                 510         
Gly Thr Glu Leu Ser Leu Ala His Cys Arg His Asp Gly Glu Asp Val
        515                 520                 525             
Ala Cys Pro Gln Gly Gly Val Gln Tyr Gly Ala Gly Val Ala Cys Ser
    530                 535                 540                 
Glu Thr Ala Pro Asp Leu Val Leu Asn Ala Glu Met Val Gln Gln Thr
545                 550                 555                 560 
Thr Tyr Leu Glu Asp Arg Pro Met Phe Met Leu Gln Cys Ala Met Glu
                565                 570                 575     
Glu Asn Cys Leu Ser Ala Ser Ala Ala Gln Thr Asp Pro Thr Thr Gly
            580                 585                 590         
Tyr Arg Arg Leu Leu Arg Phe Ser Ser Gln Ile His Asn Asn Gly Gln
        595                 600                 605             
Ser Asp Phe Arg Pro Lys Asn Gly Arg His Ala Trp Ile Trp His Asp
    610                 615                 620                 
Cys His Arg His Tyr His Ser Met Glu Val Phe Thr His Tyr Asp Leu
625                 630                 635                 640 
Leu Asn Leu Asn Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe
                645                 650                 655     
Cys Leu Glu Asp Thr Glu Cys Glu Gly Asp Ile Gln Lys Asn Tyr Glu
            660                 665                 670         
Cys Ala Asn Phe Gly Asp Gln Gly Ile Thr Met Gly Cys Trp Asp Met
        675                 680                 685             
Tyr Arg His Asp Ile Asp Cys Gln Trp Val Asp Ile Thr Asp Val Pro
    690                 695                 700                 
Pro Gly Asp Tyr Leu Phe Gln Val Val Ile Asn Pro Asn Phe Glu Val
705                 710                 715                 720 
Ala Glu Ser Asp Tyr Ser Asn Asn Ile Met Lys Cys Arg Ser Arg Tyr
                725                 730                 735     
Asp Gly His Arg Ile Trp Met Tyr Asn Cys His Ile Gly Gly Ser Phe
            740                 745                 750         
Ser Glu Glu Thr Glu Lys Lys Phe Glu His Phe Ser Gly Leu Leu Asn
        755                 760                 765             
Asn Gln Leu Ser Pro Gln
    770                 


<210> 23
<211> 1604
<212> DNA
<213> Homo sapiens

<220>
<221> modified_base
<222> (1530)..(1530)
<223> n = a, c, g, t, unknown or other

<400> 23
gggcgtgatt tgagccccgt ttttattttc tgtgagccac gtcctcctcg agggggtcaa     60
tctggccaaa aggagtgatg cgcttcgcct ggaccgtgct cctgctcggg cctttgcagc    120
tctgcgcgct agtgcactgc gcccctcccg ccgccggcca acagcagccc ccgcgcgagc    180
cgccggcggc tccgggcgcc tggcgccagc agatccaatg ggagaacaac gggcaggtgt    240
tcagcttgct gagcctgggc tcacagtacc agcctcagcg ccgccgggac ccgggcgccg    300
ccgtccctgg tgcagccaac gcctccgccc agcagccccg cactccgatc ctgctgatcc    360
gcgacaaccg caccgccgcg gcgcgaacgc ggacggccgg ctcatctgga gtcaccgctg    420
gccgccccag gcccaccgcc cgtcactggt tccaagctgg ctactcgaca tctagagccc    480
gcgaacgtgg cgcctcgcgc gcggagaacc agacagcgcc gggagaagtt cctgcgctca    540
gtaacctgcg gccgcccagc cgcgtggacg gcatggtggg cgacgaccct tacaacccct    600
acaagtactc tgacgacaac ccttattaca actactacga tacttatgaa aggcccagac    660
ctgggggcag gtaccggccc ggatacggca ctggctactt ccagtacggt ctcccagacc    720
tggtggccga cccctactac atccaggcgt ccacgtacgt gcagaagatg tccatgtaca    780
acctgagatg cgcggcggag gaaaactgtc tggccagtac agcatacagg gcagatgtca    840
gagattatga tcacagggtg ctgctcagat ttccccaaag agtgaaaaac caagggacat    900
cagatttctt acccagccga ccaagatatt cctgggaatg gcacagttgt catcaacatt    960
accacagtat ggatgagttt agccactatg acctgcttga tgccaacacc cagaggagag   1020
tggctgaagg ccacaaagca agtttctgtc ttgaagacac atcctgtgac tatggctacc   1080
acaggcgatt tgcatgtact gcacacacac agggattgag tcctggctgt tatgatacct   1140
atggtgcaga catagactgc cagtggattg atattacaga tgtaaaacct ggaaactata   1200
tcctaaaggt cagtgtaaac cccagctacc tggttcctga atctgactat accaacaatg   1260
ttgtgcgctg tgacattcgc tacacaggac atcatgcgta tgcctcaggc tgcacaattt   1320
caccgtatta gaaggcaaag caaaactccc aatggataaa tcagtgcctg gtgttctgaa   1380
gtgggaaaaa atagactaac ttcagtagga tttatgtatt ttgaaaaaga gaacagaaaa   1440
caacaaaaga atttttgttt ggactgtttt caataacaaa gcacataact ggattttgaa   1500
cgcttaagtc aatcattact tggaaatttn taatgtttat tatttacatc aactttgtga   1560
attaacacag tgtttcaatt ctgtaatttc atatttgact cttt                    1604


<210> 24
<211> 417
<212> PRT
<213> Homo sapiens

<400> 24
Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys 
1               5                   10                  15      
Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
            20                  25                  30          
Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
        35                  40                  45              
Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
    50                  55                  60                  
Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
65                  70                  75                  80  
Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
                85                  90                  95      
Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
            100                 105                 110         
Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
        115                 120                 125             
Tyr Ser Thr Ser Arg Ala Arg Glu Arg Gly Ala Ser Arg Ala Glu Asn 
    130                 135                 140                 
Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
145                 150                 155                 160 
Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
                165                 170                 175     
Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
            180                 185                 190         
Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
        195                 200                 205             
Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
    210                 215                 220                 
Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
225                 230                 235                 240 
Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
                245                 250                 255     
Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
            260                 265                 270         
Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
        275                 280                 285             
His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr 
    290                 295                 300                 
Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys 
305                 310                 315                 320 
Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
                325                 330                 335     
Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr 
            340                 345                 350         
Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp 
        355                 360                 365             
Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr 
    370                 375                 380                 
Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile 
385                 390                 395                 400 
Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro 
                405                 410                 415     
Tyr 
    


<210> 25
<211> 1254
<212> DNA
<213> Homo sapiens

<400> 25
atgcgcttcg cctggaccgt gctcctgctc gggcctttgc agctctgcgc gctagtgcac     60
tgcgcccctc ccgccgccgg ccaacagcag cccccgcgcg agccgccggc ggctccgggc    120
gcctggcgcc agcagatcca atgggagaac aacgggcagg tgttcagctt gctgagcctg    180
ggctcacagt accagcctca gcgccgccgg gacccgggcg ccgccgtccc tggtgcagcc    240
aacgcctccg cccagcagcc ccgcactccg atcctgctga tccgcgacaa ccgcaccgcc    300
gcggcgcgaa cgcggacggc cggctcatct ggagtcaccg ctggccgccc caggcccacc    360
gcccgtcact ggttccaagc tggctactcg acatctagag cccgcgaacg tggcgcctcg    420
cgcgcggaga accagacagc gccgggagaa gttcctgcgc tcagtaacct gcggccgccc    480
agccgcgtgg acggcatggt gggcgacgac ccttacaacc cctacaagta ctctgacgac    540
aacccttatt acaactacta cgatacttat gaaaggccca gacctggggg caggtaccgg    600
cccggatacg gcactggcta cttccagtac ggtctcccag acctggtggc cgacccctac    660
tacatccagg cgtccacgta cgtgcagaag atgtccatgt acaacctgag atgcgcggcg    720
gaggaaaact gtctggccag tacagcatac agggcagatg tcagagatta tgatcacagg    780
gtgctgctca gatttcccca aagagtgaaa aaccaaggga catcagattt cttacccagc    840
cgaccaagat attcctggga atggcacagt tgtcatcaac attaccacag tatggatgag    900
tttagccact atgacctgct tgatgccaac acccagagga gagtggctga aggccacaaa    960
gcaagtttct gtcttgaaga cacatcctgt gactatggct accacaggcg atttgcatgt   1020
actgcacaca cacagggatt gagtcctggc tgttatgata cctatggtgc agacatagac   1080
tgccagtgga ttgatattac agatgtaaaa cctggaaact atatcctaaa ggtcagtgta   1140
aaccccagct acctggttcc tgaatctgac tataccaaca atgttgtgcg ctgtgacatt   1200
cgctacacag gacatcatgc gtatgcctca ggctgcacaa tttcaccgta ttag         1254


<210> 26
<211> 417
<212> PRT
<213> Homo sapiens

<400> 26
Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys 
1               5                   10                  15      
Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
            20                  25                  30          
Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
        35                  40                  45              
Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
    50                  55                  60                  
Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
65                  70                  75                  80  
Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
                85                  90                  95      
Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
            100                 105                 110         
Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
        115                 120                 125             
Tyr Ser Thr Ser Arg Ala Arg Glu Arg Gly Ala Ser Arg Ala Glu Asn 
    130                 135                 140                 
Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
145                 150                 155                 160 
Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
                165                 170                 175     
Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
            180                 185                 190         
Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
        195                 200                 205             
Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
    210                 215                 220                 
Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
225                 230                 235                 240 
Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
                245                 250                 255     
Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
            260                 265                 270         
Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
        275                 280                 285             
His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr 
    290                 295                 300                 
Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys 
305                 310                 315                 320 
Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
                325                 330                 335     
Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr 
            340                 345                 350         
Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp 
        355                 360                 365             
Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr 
    370                 375                 380                 
Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile 
385                 390                 395                 400 
Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro 
                405                 410                 415     
Tyr 
    


<210> 27
<211> 1780
<212> DNA
<213> Homo sapiens

<400> 27
gggccaggac tgagaaaggg gaaagggaag ggtgccacgt ccgagcagcc gccttgactg     60
gggaagggtc tgaatcccac ccttggcatt gcttggtgga gactgagata cccgtgctcc    120
gctcgcctcc ttggttgaag atttctcctt ccctcacgtg atttgagccc cgtttttatt    180
ttctgtgagc cacgtcctcc tcgagcgggg tcaatctggc aaaaggagtg atgcgcttcg    240
cctggaccgt gctcctgctc gggcctttgc agctctgcgc gctagtgcac tgcgcccctc    300
ccgccgccgg ccaacagcag cccccgcgcg agccgccggc ggctccgggc gcctggcgcc    360
agcagatcca atgggagaac aacgggcagg tgttcagctt gctgagcctg ggctcacagt    420
accagcctca gcgccgccgg gacccgggcg ccgccgtccc tggtgcagcc aacgcctccg    480
cccagcagcc ccgcactccg atcctgctga tccgcgacaa ccgcaccgcc gcggggcgaa    540
cgcggacggc cggctcatct ggagtcaccg ctggccgccc caggcccacc gcccgtcact    600
ggttccaagc tggctactcg acatctagag cccgcgaagc tgggccctcg cgcgcggaga    660
accagacagc gccgggagaa gttcctgctc tcagtaacct gcggccgccc agccgcgtgg    720
acggcatggt gggcgacgac ccttacaacc cctacaagta ctctgacgac aacccttatt    780
acaactacta cgatacttat gaaaggccca gacctggggg caggtaccgg cccggatacg    840
gcactggcta cttccagtac ggtctcccag acctggtggc cgacccctac tacatccagg    900
cgtccacgta cgtgcagaag atgtccatgt acaacctgag atgcgcggcg gaggaaaact    960
gtctggccag tacagcatac agggcagatg tcagagatta tgatcacagg gtgctgctca   1020
gatttcccca aagagtgaaa aaccaaggga catcagattt cttacccagc cgaccaagat   1080
attcctggga atggcacagt tgtcatcaac attaccacag tatggatgag tttagccact   1140
tgtacctgct tgatgccaac acccagagga gatgggctga aggccacaaa gcaagtttct   1200
gtcttgaaga cacatcctgt gactatggct accacaggcg atttgcatgt actgcacaca   1260
cacagggatt gagtcctggc tgttatgata cctatggtgc agacatagac tgccagtgga   1320
ttgatattac agatgtaaaa cctggaaact atatcctaaa ggtcagtgta aaccccagct   1380
acctggttcc tgaatctgac tataccaaca atgttgtgcg ctgtgacatt cgctacacag   1440
gacatcatgc gtatgcctca ggctgcacaa tttcaccgta ttagaaggca aagcaaaact   1500
cccaatggat aaatcagtgc ctggtgttct gaagtgggaa aaaatagact aacttcagta   1560
ggatttatgt attttgaaaa agagaacaga aaacaacaaa agaatttttg tttggactgt   1620
tttcaataac aaagcacata actggatttt gaacgcttaa gtcatcatta cttgggaaat   1680
ttttaatgtt tattatttac atcactttgt gaattaacac agtgtttcaa ttctgtaatt   1740
acatatttga ctctttcaaa aaaaaaaaaa aaaaaaaaaa                         1780


<210> 28
<211> 417
<212> PRT
<213> Homo sapiens

<400> 28
Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys 
1               5                   10                  15      
Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
            20                  25                  30          
Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
        35                  40                  45              
Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
    50                  55                  60                  
Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
65                  70                  75                  80  
Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
                85                  90                  95      
Asn Arg Thr Ala Ala Gly Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
            100                 105                 110         
Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
        115                 120                 125             
Tyr Ser Thr Ser Arg Ala Arg Glu Ala Gly Pro Ser Arg Ala Glu Asn 
    130                 135                 140                 
Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
145                 150                 155                 160 
Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
                165                 170                 175     
Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
            180                 185                 190         
Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
        195                 200                 205             
Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
    210                 215                 220                 
Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
225                 230                 235                 240 
Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
                245                 250                 255     
Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
            260                 265                 270         
Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
        275                 280                 285             
His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Leu 
    290                 295                 300                 
Tyr Leu Leu Asp Ala Asn Thr Gln Arg Arg Trp Ala Glu Gly His Lys 
305                 310                 315                 320 
Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
                325                 330                 335     
Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr 
            340                 345                 350         
Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp 
        355                 360                 365             
Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr 
    370                 375                 380                 
Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile 
385                 390                 395                 400 
Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro 
                405                 410                 415     
Tyr 


<210> 29
<211> 1935
<212> DNA
<213> Homo sapiens

<400> 29
ccgcgccgct ccccgttgcc ttccaggact gagaaagggg aaagggaagg gtgccacgtc     60
cgagcagccg ccttgactgg ggaagggtct gaatcccacc cttggcattg cctggtggag    120
actgagatac ccgtgctccg ctcgcctcct tggttgaaga tttctccttc cctcacgtga    180
tttgagcccc gtttttattt tctgtgagcc acgtcctcct cgagcggggt caatctggca    240
aaaggagtga tgcgcttcgc ctggaccgtg ctcctgctcg ggcctttgca gctctgcgcg    300
ctagtgcact gcgcccctcc cgccgccggc caacagcagc ccccgcgcga gccgccggcg    360
gctccgggcg cctggcgcca gcagatccaa tgggagaaca acgggcaggt gttcagcttg    420
ctgagcctgg gctcacagta ccagcctcag cgccgccggg acccgggcgc cgccgtccct    480
ggtgcagcca acgcctccgc ccagcagccc cgcactccga tcctgctgat ccgcgacaac    540
cgcaccgccg cggcgcgaac gcggacggcc ggctcatctg gagtcaccgc tggccgcccc    600
aggcccaccg cccgtcactg gttccaagct ggctactcga catctagagc ccgcgaagct    660
ggcgcctcgc gcgcggagaa ccagacagcg ccgggagaag ttcctgcgct cagtaacctg    720
cggccgccca gccgcgtgga cggcatggtg ggcgacgacc cttacaaccc ctacaagtac    780
tctgacgaca acccttatta caactactac gatacttatg aaaggcccag acctgggggc    840
aggtaccggc ccggatacgg cactggctac ttccagtacg gtctcccaga cctggtggcc    900
gacccctact acatccaggc gtccacgtac gtgcagaaga tgtccatgta caacctgaga    960
tgcgcggcgg aggaaaactg tctggccagt acagcataca gggcagatgt cagagattat   1020
gatcacaggg tgctgctcag atttccccaa agagtgaaaa accaagggac atcagatttc   1080
ttacccagcc gaccaagata ttcctgggaa tggcacagtt gtcatcaaca ttaccacagt   1140
atggatgagt ttagccacta tgacctgctt gatgccaaca cccagaggag agtggctgaa   1200
ggccacaaag caagtttctg tcttgaagac acatcctgtg actatggcta ccacaggcga   1260
tttgcatgta ctgcacacac acagggattg agtcctggct gttatgatac ctatggtgca   1320
gacatagact gccagtggat tgatattaca gatgtaaaac ctggaaacta tatcctaaag   1380
gtcagtgtaa accccagcta cctggttcct gaatctgact ataccaacaa tgttgtgcgc   1440
tgtgacattc gctacacagg acatcatgcg tatgcctcag gctgcacaat ttcaccgtat   1500
tagaaggcaa agcaaaactc ccaatggata aatcagtgcc tggtgttctg aagtgggaaa   1560
aaatagacta acttcagtag gatttatgta ttttgaaaaa gagaacagaa aacaacaaaa   1620
gaatttttgt ttggactgtt ttcaataaca aagcacataa ctggattttg aacgcttaag   1680
tcatcattac ttgggaaatt tttaatgttt attatttaca tcactttgtg aattaacaca   1740
gtgtttcaat tctgtaatta catatttgac tctttcaaag aaatccaaat ttctcatgtt   1800
ccttttgaaa ttgtagtgca aaatggtcag tattatctaa atgaatgagc caaaatgact   1860
ttgaactgaa acttttctaa agtgctggaa ctttagtgaa acataataat aatgggttta   1920
tacgacagca acgga                                                    1935


<210> 30
<211> 417
<212> PRT
<213> Homo sapiens

<400> 30
Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys 
1               5                   10                  15      
Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
            20                  25                  30          
Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
        35                  40                  45              
Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
    50                  55                  60                  
Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
65                  70                  75                  80  
Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
                85                  90                  95      
Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
            100                 105                 110         
Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
        115                 120                 125             
Tyr Ser Thr Ser Arg Ala Arg Glu Ala Gly Ala Ser Arg Ala Glu Asn 
    130                 135                 140                 
Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
145                 150                 155                 160 
Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
                165                 170                 175     
Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
            180                 185                 190         
Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
        195                 200                 205             
Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
    210                 215                 220                 
Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
225                 230                 235                 240 
Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
                245                 250                 255     
Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
            260                 265                 270         
Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
        275                 280                 285             
His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr 
    290                 295                 300                 
Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys 
305                 310                 315                 320 
Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
                325                 330                 335     
Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr 
            340                 345                 350         
Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp 
        355                 360                 365             
Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr 
    370                 375                 380                 
Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile 
385                 390                 395                 400 
Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro 
                405                 410                 415     
Tyr 
    


<210> 31
<211> 1322
<212> DNA
<213> Homo sapiens

<400> 31
ggtcaatctg gcaaaaggag tgatgcgctt cgcctggacc gtgctcctgc tcgggccttt     60
gcagctctgc gcgctagtgc actgcgcccc tcccgccgcc ggccaacagc agcccccgcg    120
cgagccgccg gcggctccgg gcgcctggcg ccagcagatc caatgggaga acaacgggca    180
ggtgttcagc ttgctgagcc tgggctcaca gtaccagcct cagcgccgcc gggacccggg    240
cgccgccgtc cctggtgcag ccaacgcctc cgcccagcag ccccgcactc cgatcctgct    300
gatccgcgac aaccgcaccg ccgcggcgcg aacgcggacg gccggctcat ctggagtcac    360
cgctggccgc cccaggccca ccgcccgtca ctggttccaa gctggctact cgacatctag    420
agcccgcgaa gctggcgcct cgcgcgcgga gaaccagaca gcgccgggag aagttcctgc    480
gctcagtaac ctgcggccgc ccagccgcgt ggacggcatg gtgggcgacg acccttacaa    540
cccctacaag tactctgacg acaaccctta ttacaactac tacgatactt atgaaaggcc    600
cagacctggg ggcaggtacc ggcccggata cggcactggc tacttccagt acggtctccc    660
agacctggtg gccgacccct actacatcca ggcgtccacg tacgtgcaga agatgtccat    720
gtacaacctg agatgcgcgg cggaggaaaa ctgtctggcc agtacagcat acagggcaga    780
tgtcagagat tatgatcaca gggtgctgct cagatttccc caaagagtga aaaaccaagg    840
gacatcagat ttcttaccca gccgaccaag atattcctgg gaatggcaca gttgtcatca    900
acattaccac agtatggatg agtttagcca ctatgacctg cttgatgcca acacccagag    960
gagagtggct gaaggccaca aagcaagttt ctgtcttgaa gacacatcct gtgactatgg   1020
ctaccacagg cgatttgcat gtactgcaca cacacaggga ttgagtcctg gctgttatga   1080
tacctatggt gcagacatag actgccagtg gattgatatt acagatgtaa aacctggaaa   1140
ctatatccta aaggtcagtg taaaccccag ctacctggtt cctgaatctg actataccaa   1200
caatgttgtg cgctgtgaca ttcgctacac aggacatcat gcgtatgcct caggctgcac   1260
aatttcaccg tattagaagg caaagcaaaa ctcccaatgg ataaatcagt gcctggtgtt   1320
ct                                                                  1322


<210> 32
<211> 417
<212> PRT
<213> Homo sapiens

<400> 32
Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys 
1               5                   10                  15      
Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
            20                  25                  30          
Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
        35                  40                  45              
Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
    50                  55                  60                  
Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
65                  70                  75                  80  
Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
                85                  90                  95      
Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
            100                 105                 110         
Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
        115                 120                 125             
Tyr Ser Thr Ser Arg Ala Arg Glu Ala Gly Ala Ser Arg Ala Glu Asn 
    130                 135                 140                 
Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
145                 150                 155                 160 
Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
                165                 170                 175     
Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
            180                 185                 190         
Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
        195                 200                 205             
Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
    210                 215                 220                 
Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
225                 230                 235                 240 
Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
                245                 250                 255     
Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
            260                 265                 270         
Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
        275                 280                 285             
His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr 
    290                 295                 300                 
Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys 
305                 310                 315                 320 
Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
                325                 330                 335     
Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr 
            340                 345                 350         
Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp 
        355                 360                 365             
Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr 
    370                 375                 380                 
Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile 
385                 390                 395                 400 
Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro 
                405                 410                 415     
Tyr 
    
<210> 33
<211> 1325
<212> DNA
<213> Homo sapiens

<400> 33
ggtcaatctg gcaaaaggag tgatgcgctt cgcctggacc gtgctcctgc tcgggccttt     60
gcagctctgc gcgctagtgc actgcgcccc tcccgccgcc ggccaacagc agcccccgcg    120
cgagccgccg gcggctccgg gcgcctggcg ccagcagatc caatgggaga acaacgggca    180
ggtgttcagc ttgctgagcc tgggctcaca gtaccagcct cagcgccgcc gggacccggg    240
cgccgccgtc cctggtgcag ccaacgcctc cgcccagcag ccccgcactc cgatcctgct    300
gatccgcgac aaccgcaccg ccgcggcgcg aacgcggacg gccggctcat ctggagtcac    360
cgctggccgc cccaggccca ccgcccgtca ctggttccaa gctggctact cgacatctag    420
agcccgcgaa gctggcgcct cgcgcgcgga gaaccagaca gcgccgggag aagttcctgc    480
gctcagtaac ctgcggccgc ccagccgcgt ggacggcatg gtgggcgacg acccttacaa    540
cccctacaag tactctgacg acaaccctta ttacaactac tacgatactt atgaaaggcc    600
cagacctggg ggcaggtacc ggcccggata cggcactggc tacttccagt acggtctccc    660
agacctggtg gccgacccct actacatcca ggcgtccacg tacgtgcaga agatgtccat    720
gtacaacctg agatgcgcgg cggaggaaaa ctgtctggcc agtacagcat acagggcaga    780
tgtcagagat tatgatcaca gggtgctgct cagatttccc caaagagtga aaaaccaagg    840
gacatcagat ttcttaccca gccgaccaag atattcctgg gaatggcaca gttgtcatca    900
acattaccac agtatggatg agtttagcca ctatgacctg cttgatgcca acacccagag    960
gagagtggct gaaggccaca aagcaagttt ctgtcttgaa gacacatcct gtgactatgg   1020
ctaccacagg cgatttgcat gtactgcaca cacacaggga ttgagtcctg gctgttatga   1080
tacctatggt gcagacatag actgccagtg gattgatatt acagatgtaa aacctggaaa   1140
ctatatccta aaggtcagtg taaaccccag ctacctggtt cctgaatctg actataccaa   1200
caatgttgtg cgctgtgaca ttcgctacac aggacatcat gcgtatgcct caggctgcac   1260
aatttcaccg tattagaagg caaagcaaaa ctcccaatgg ataaatcagt gcctggtgtt   1320
ctgaa                                                               1325


<210> 34
<211> 407
<212> PRT
<213> Homo sapiens

<400> 34
Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys 
1               5                   10                  15      
Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
            20                  25                  30          
Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
        35                  40                  45              
Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
    50                  55                  60                  
Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
65                  70                  75                  80  
Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
                85                  90                  95      
Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
            100                 105                 110         
Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
        115                 120                 125             
Tyr Ser Thr Ser Arg Ala Arg Glu Ala Gly Ala Ser Arg Ala Glu Asn 
    130                 135                 140                 
Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
145                 150                 155                 160 
Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
                165                 170                 175     
Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
            180                 185                 190         
Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
        195                 200                 205             
Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
    210                 215                 220                 
Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
225                 230                 235                 240 
Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
                245                 250                 255     
Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
            260                 265                 270         
Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
        275                 280                 285             
His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr 
    290                 295                 300                 
Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys 
305                 310                 315                 320 
Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
                325                 330                 335     
Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Gln 
            340                 345                 350         
Trp Ile Asp Ile Thr Asp Val Lys Pro Gly Asn Tyr Ile Leu Lys Val 
        355                 360                 365             
Ser Val Asn Pro Ser Tyr Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn 
    370                 375                 380                 
Val Val Arg Cys Asp Ile Arg Tyr Thr Gly His His Ala Tyr Ala Ser 
385                 390                 395                 400 
Gly Cys Thr Ile Ser Pro Tyr 
                405         


<210> 35
<211> 842
<212> DNA
<213> Homo sapiens

<400> 35
gttcagcttg ctgagcctgg gctcacagta ccagcctcag cgccgccggg acccgggcgc     60
cgccgtccct ggtgcagcca acgcctccgc ccagcagccc cgcactccga tcctgctgat    120
ccgcgacaac cgcaccgccg cggcgcgaac gcggacggcc ggctcatctg gagtcaccgc    180
tggccgcccc aggcccaccg cccgtcactg gttccaagct ggctactcga catctagagc    240
ccgcgaagct ggcgcctcgc gcgcggagaa ccagacagcg ccgggagaag ttcctgcgct    300
cagtaacctg cggccgccca gccgcgtgga cggcatggtg ggcgacgacc cttacaaccc    360
ctacaagtac tctgacgaca acccttatta caactactac gatacttatg aaaggcccag    420
acctgggggc aggtaccggc ccggatacgg cactggctac ttccagtacg gtaagtaccc    480
ccaagtccgc tggaagcacc cgtgcacctg gtccccagct atgtggcttc ttctcgacgt    540
ggctgcctgg gcgcggcggg ccccggtcct cgcagatccg acccctcccc acgcgcctgc    600
agtggcagcc ctggaatcca gtgcaaaccg cgcgtctggc ccctcctgct tccttttcac    660
attgctttgc agtcccgggg gtccccagtt ctcttgctgt cctccgctcc actctgcagt    720
cccggtgggc gaagggtgag gagtaaggga cctagagggg tagggagttg gagcgggggg    780
cgccgggttg tttcactgct gcgcccgtcg cctgctgacg tttaggtctc ccagacctgg    840
tg                                                                   842


<210> 36
<211> 162
<212> PRT
<213> Homo sapiens

<400> 36
Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr Gln Pro Gln Arg Arg Arg 
1               5                   10                  15      
Asp Pro Gly Ala Ala Val Pro Gly Ala Ala Asn Ala Ser Ala Gln Gln 
            20                  25                  30          
Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp Asn Arg Thr Ala Ala Ala 
        35                  40                  45              
Arg Thr Arg Thr Ala Gly Ser Ser Gly Val Thr Ala Gly Arg Pro Arg 
    50                  55                  60                  
Pro Thr Ala Arg His Trp Phe Gln Ala Gly Tyr Ser Thr Ser Arg Ala 
65                  70                  75                  80  
Arg Glu Ala Gly Ala Ser Arg Ala Glu Asn Gln Thr Ala Pro Gly Glu 
                85                  90                  95      
Val Pro Ala Leu Ser Asn Leu Arg Pro Pro Ser Arg Val Asp Gly Met 
            100                 105                 110         
Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys Tyr Ser Asp Asp Asn Pro 
        115                 120                 125             
Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg Pro Arg Pro Gly Gly Arg 
    130                 135                 140                 
Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe Gln Tyr Gly Leu Pro Asp 
145                 150                 155                 160 
Leu Val 
        

<210> 37
<211> 135
<212> PRT
<213> Mus sp.

<400> 37
Met Glu Trp Ser Arg Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
        35                  40                  45              


Thr Tyr Tyr Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Asn Trp Met Asn Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser 
    130                 135 


<210> 38
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polypeptide 

<400> 38
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Tyr Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Trp Met Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 39
<211> 116
<212> PRT
<213> Artificial Sequence 

<220>
<223> Description of Artificial Sequence: Synthetic 
      polypeptide 

<400> 39
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Tyr Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Trp Met Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 40
<211> 116
<212> PRT
<213> Artificial Sequence 

<220>
<223> Description of Artificial Sequence: Synthetic 
      polypeptide 

<400> 40
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Tyr Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Trp Met Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 41
<211> 116
<212> PRT
<213> Artificial Sequence 

<220>
<223> Description of Artificial Sequence: Synthetic 
      polypeptide 

<400> 41
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Tyr Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Trp Met Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 42
<211> 132
<212> PRT
<213> Mus sp.

<400> 42
Met Arg Cys Leu Ala Glu Phe Leu Gly Leu Leu Val Leu Trp Ile Pro 
1               5                   10                  15      


Gly Ala Ile Gly Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Ser 
            20                  25                  30          


Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Phe Leu Ile Tyr Arg Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210> 43
<211> 112
<212> PRT
<213> Artificial Sequence 

<220>
<223> Description of Artificial Sequence: Synthetic 
      polypeptide 

<400> 43
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 44
<211> 112
<212> PRT
<213> Artificial Sequence 

<220>
<223> Description of Artificial Sequence: Synthetic 
      polypeptide 

<400> 44
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 45
<211> 112
<212> PRT
<213> Artificial Sequence 

<220>
<223> Description of Artificial Sequence: Synthetic 
      polypeptide 

<400> 45
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 46
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide

<400> 46
Gly Tyr Ala Phe Thr Tyr Tyr Leu Ile Glu 
1               5                   10  


<210> 47
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide

<400> 47
Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    

<210> 48
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide

<400> 48
Asn Trp Met Asn Phe Asp Tyr 
1               5           


<210> 49
<211> 16
<212> PRT
<213> Artificial Sequence 

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 49
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210> 50
<211> 7
<212> PRT
<213> Artificial Sequence 

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 50
Arg Met Ser Asn Leu Ala Ser 
1               5           


<210> 51
<211> 9
<212> PRT
<213> Artificial Sequence 

<220>
<223> Description of Artificial Sequence: Synthetic 
      peptide 

<400> 51
Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


