                         SEQUENCE LISTING

<110>  SAHA, Saurabh
 
<120>  COMBINATION THERAPIES USING AGENTS THAT TARGET TUMOR-ASSOCIATED STROMA OR TUMOR CELLS AND TUMOR VASCULATURE

<130>  C065272/0385321

<150>  US 62/009,369
<151>  2014-06-09

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  TEM825 mAB VH polypeptide

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Pro Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Gly Glu Glu Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Asp Tyr Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  2
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  TEM825 mAb VL polypeptide

<400>  2

Ser Ser Glu Leu Thr Gln Asp Pro Val Val Ser Val Ala Leu Gly Glu 
1               5                   10                  15      


Thr Val Ser Ile Thr Cys Gln Gly Asp Asn Leu Arg Asp Phe Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Met Tyr 
        35                  40                  45              


Gly Lys Asn Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asn Thr Leu Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Asn Ser Lys His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  3
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  TEM822 mAb VH

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Asp Tyr Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  4
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  TEM822 mAb VL

<400>  4

Ser Ser Glu Leu Thr Gln Asp Pro Val Val Ser Val Ala Leu Gly Glu 
1               5                   10                  15      


Thr Val Ser Ile Thr Cys Gln Gly Asp Asn Leu Arg Asp Phe Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Met Tyr 
        35                  40                  45              


Gly Lys Asn Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asn Thr Leu Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Asn Ser Lys His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  5
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  TEM830 mAb VH

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Pro Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Ser Ser Trp Tyr Arg Gly Asn Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  TEM830 mAb VL

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Gln Thr Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210>  7
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  TEM863 mAb VH

<400>  7

Glu Val Gln Leu Val Glu Thr Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Thr Ser Gly Ser Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Pro Gly Ser Pro Lys Trp Leu Ala Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  TEM863 mAb VL

<400>  8

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Ala Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210>  9
<211>  5909
<212>  DNA
<213>  Homo sapiens

<400>  9
atcatattta aaatctggga caaagaaccg tcgggacgga actccttcca ttgcaaaagc       60

tcggcgcggc ctcgggagct gcccggcggc cccggaccga ggcagccctc ccctttaaaa      120

gaagcggagg acaggattgg gatccttgaa acccgaaacc cagaaacagc atcggagcgg      180

aaaccagagg ggaaaccttg aactcctcca gacaattgct tccggggagt tgcgagggag      240

cgagggggaa taaaggaccc gcgaggaagg gcccgcggat ggcgcgtccc tgagggtcgt      300

ggcgagttcg cggagcgtgg gaaggagcgg accctgctct ccccgggctg cgggccatgg      360

ccacggcgga gcggagagcc ctcggcatcg gcttccagtg gctctctttg gccactctgg      420

tgctcatctg cgccgggcaa gggggacgca gggaggatgg gggtccagcc tgctacggcg      480

gatttgacct gtacttcatt ttggacaaat caggaagtgt gctgcaccac tggaatgaaa      540

tctattactt tgtggaacag ttggctcaca aattcatcag cccacagttg agaatgtcct      600

ttattgtttt ctccacccga ggaacaacct taatgaaact gacagaagac agagaacaaa      660

tccgtcaagg cctagaagaa ctccagaaag ttctgccagg aggagacact tacatgcatg      720

aaggatttga aagggccagt gagcagattt attatgaaaa cagacaaggg tacaggacag      780

ccagcgtcat cattgctttg actgatggag aactccatga agatctcttt ttctattcag      840

agagggaggc taataggtct cgagatcttg gtgcaattgt ttactgtgtt ggtgtgaaag      900

atttcaatga gacacagctg gcccggattg cggacagtaa ggatcatgtg tttcccgtga      960

atgacggctt tcaggctctg caaggcatca tccactcaat tttgaagaag tcctgcatcg     1020

aaattctagc agctgaacca tccaccatat gtgcaggaga gtcatttcaa gttgtcgtga     1080

gaggaaacgg cttccgacat gcccgcaacg tggacagggt cctctgcagc ttcaagatca     1140

atgactcggt cacactcaat gagaagccct tttctgtgga agatacttat ttactgtgtc     1200

cagcgcctat cttaaaagaa gttggcatga aagctgcact ccaggtcagc atgaacgatg     1260

gcctctcttt tatctccagt tctgtcatca tcaccaccac acactgttct gacggttcca     1320

tcctggccat cgccctgctg atcctgttcc tgctcctagc cctggctctc ctctggtggt     1380

tctggcccct ctgctgcact gtgattatca aggaggtccc tccaccccct gccgaggaga     1440

gtgaggaaga agatgatgat ggtctgccta agaaaaagtg gccaacggta gacgcctctt     1500

attatggtgg gagaggcgtt ggaggcatta aaagaatgga ggttcgttgg ggagaaaagg     1560

gctccacaga agaaggtgct aagttggaaa aggcaaagaa tgcaagagtc aagatgccgg     1620

agcaggaata tgaattccct gagccgcgaa atctcaacaa caatatgcgt cggccttctt     1680

ccccccggaa gtggtactct ccaatcaagg gaaaactcga tgccttgtgg gtcctactga     1740

ggaaaggata tgatcgtgtg tctgtgatgc gtccacagcc aggagacacg gggcgctgca     1800

tcaacttcac cagggtcaag aacaaccagc cagccaagta cccactcaac aacgcctacc     1860

acacctcctc gccgcctcct gcccccatct acactccccc acctcctgcg ccccactgcc     1920

ctcccccgcc ccccagcgcc cctacccctc ccatcccgtc cccaccttcc acccttcccc     1980

ctcctcccca ggctccacct cccaacaggg cacctcctcc ctcccgccct cctccaaggc     2040

cttctgtcta gagcccaaag ttcctgctct gggctctctc agaaacttca ggagatgtta     2100

gaacaagtct ttccagttag agaagaggag tggtgataaa gcccactgac cttcacacat     2160

tctaaaaatt ggttggcaat gccagtatac caacaatcat gatcagctga aagaaacaga     2220

tattttaaat tgccagaaaa caaatgatga ggcaactaca gtcagattta tagccagcca     2280

tctatcacct ctagaaggtt ccagagacag tgaaactgca agatgctctc aacaggatta     2340

tgtctcatgg agaccagtaa gaaaatcatt tatctgaagg tgaaatgcag agttggataa     2400

gaaatacatt gctgggtttc taaaatgctg ccttcctgcc tctactccac ctccatccct     2460

ggactttgga cccttggcct aggagcctaa ggaccttcac ccctgtgcac cacccaagaa     2520

agaggaaaac tttgcctaca actttggaaa tgctggggtc cctggtgtgg taagaaactc     2580

aacatcagac gggtatgcag aaggatgttc ttctgggatt tgcaggtaca taaaaaatgt     2640

atggcatctt ttccttgcaa attcttccag tttccaagtg agaaggggag caggtgttta     2700

ctgatggaaa aggtatgttg ctatgttgat gtgtaagtga aatcagttgt gtgcaataga     2760

caggggcgta ttcatgggag catcagccag tttctaaaac ccacaggcca tcagcagcta     2820

gaggtggctg gctttggcca gacatggacc ctaaatcaac agacaatggc attgtcgaag     2880

agcaacctgt taatgaatca tgttaaaaat caaggtttgg cttcagttta aatcacttga     2940

ggtatgaagt ttatcctgtt ttccagagat aaacataagt tgatcttccc aaaataccat     3000

cattaggacc tatcacacaa tatcactagt tttttttgtt tgtttgtttt ttgttttttt     3060

tcttggtaaa gccatgcacc acagacttct gggcagagct gagagacaat ggtcctgaca     3120

taataaggat ctttgattaa cccccataag gcatgtgtgt gtatacaaat atacttctct     3180

ttggcttttc gacatagaac ctcagctgtt aaccaagggg aaatacatca gatctgcaac     3240

acagaaatgc tctgcctgaa atttccacca tgcctaggac tcaccccatt tatccaggtc     3300

tttctggatc tgtttaatca ataagcccta taatcacttg ctaaacactg ggcttcatca     3360

cccagggata aaaacagaga tcattgtctt ggacctcctg catcagccta ttcaaaatta     3420

tctctctctc tagctttcca caaatcctaa aattcctgtc ccaagccacc caaattctca     3480

gatcttttct ggaacaaggc agaatataaa ataaatatac atttagtggc ttgggctatg     3540

gtctccaaag atccttcaaa aatacatcaa gccagcttca ttcactcact ttacttagaa     3600

cagagatata agggcctggg atgcatttat tttatcaata ccaatttttg tggccatggc     3660

agacattgct aatcaatcac agcactattt cctattaagc ccactgattt cttcacaatc     3720

cttctcaaat tacaattcca aagagccgcc actcaacagt cagatgaacc caacagtcag     3780

atgagagaaa tgaaccctac ttgctatctc tatcttagaa agcaaaaaca aacaggagtt     3840

tccagggaga atgggaaagc cagggggcat aaaaggtaca gtcaggggaa aatagatcta     3900

ggcagagtgc cttagtcagg gaccacgggc gctgaatctg cagtgccaac accaaactga     3960

cacatctcca ggtgtacctc caaccctagc cttctcccac agctgcctac aacagagtct     4020

cccagccttc tcagagagct aaaaccagaa atttccagac tcatgaaagc aaccccccag     4080

cctctcccca accctgccgc attgtctaat ttttagaaca ctaggcttct tctttcatgt     4140

agttcctcat aagcaggggc cagaatatct cagccacctg cagtgacatt gctggacccc     4200

tgaaaaccat tccataggag aatgggttcc ccaggctcac agtgtagaga cattgagccc     4260

atcacaactg ttttgactgc tggcagtcta aaacagtcca cccaccccat ggcactgccg     4320

cgtgattccc gcggccattc agaagttcaa gccgagatgc tgacgttgct gagcaacgag     4380

atggtgagca tcagtgcaaa tgcaccattc agcacatcag tcatatgccc agtgcagtta     4440

caagatgttg tttcggcaaa gcattttgat ggaataggga actgcaaatg tatgatgatt     4500

ttgaaaaggc tcagcaggat ttgttcttaa accgactcag tgtgtcatcc ccggttattt     4560

agaattacag ttaagaagga gaaacttcta taagactgta tgaacaaggt gatatcttca     4620

tagtgggcta ttacaggcag gaaaatgttt taactggttt acaaaatcca tcaatacttg     4680

tgtcattccc tgtaaaaggc aggagacatg tgattatgat caggaaactg cacaaaatta     4740

ttgttttcag cccccgtgtt attgtccttt tgaactgttt ttttttttat taaagccaaa     4800

tttgtgttgt atatattcgt attccatgtg ttagatggaa gcatttccta tccagtgtga     4860

ataaaaagaa cagttgtagt aaattattat aaagccgatg atatttcatg gcaggttatt     4920

ctaccaagct gtgcttgttg gtttttccca tgactgtatt gcttttataa atgtacaaat     4980

agttactgaa atgacgagac ccttgtttgc acagcattaa taagaacctt gataagaacc     5040

atattctgtt gacagccagc tcacagtttc ttgcctgaag cttggtgcac cctccagtga     5100

gacacaagat ctctctttta ccaaagttga gaacagagct ggtggattaa ttaatagtct     5160

tcgatatctg gccatgggta acctcattgt aactatcatc agaatgggca gagatgatct     5220

tgaagtgtca catacactaa agtccaaaca ctatgtcaga tgggggtaaa atccattaaa     5280

gaacaggaaa aaataattat aagatgataa gcaaatgttt cagcccaatg tcaacccagt     5340

taaaaaaaaa attaatgctg tgtaaaatgg ttgaattagt ttgcaaacta tataaagaca     5400

tatgcagtaa aaagtctgtt aatgcacatc ctgtgggaat ggagtgttct aaccaattgc     5460

cttttcttgt tatctgagct ctcctatatt atcatactca gataaccaaa ttaaaagaat     5520

tagaatatga tttttaatac acttaacatt aaactcttct aactttcttc tttctgtgat     5580

aattcagaag atagttatgg atcttcaatg cctctgagtc attgttataa aaaatcagtt     5640

atcactatac catgctatag gagactgggc aaaacctgta caatgacaac cctggaagtt     5700

gcttttttta aaaaaataat aaatttctta aatcaactct tttttctggt tgtctgtttg     5760

ttataaagtg caacgtattc aagtcctcaa tatcctgatc ataataccat gctataggag     5820

actgggcaaa acctgtacaa tgacaaccct ggaagttgct tttttaaaaa aaataataaa     5880

tttcttaaat caaaaaaaaa aaaaaaaaa                                       5909


<210>  10
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Thr Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Thr Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Thr Arg Gly Thr Thr Leu Met Lys Leu Thr 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Thr Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Thr Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Thr Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Thr Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Thr Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Thr Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Thr Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Thr Thr Thr His Cys Ser Asp Gly 
305                 310                 315                 320 


Ser Ile Leu Ala Ile Ala Leu Leu Ile Leu Phe Leu Leu Leu Ala Leu 
                325                 330                 335     


Ala Leu Leu Trp Trp Phe Trp Pro Leu Cys Cys Thr Val Ile Ile Lys 
            340                 345                 350         


Glu Val Pro Pro Pro Pro Ala Glu Glu Ser Glu Glu Glu Asp Asp Asp 
        355                 360                 365             


Gly Leu Pro Lys Lys Lys Trp Pro Thr Val Asp Ala Ser Tyr Tyr Gly 
    370                 375                 380                 


Gly Arg Gly Val Gly Gly Ile Lys Arg Met Glu Val Arg Trp Gly Glu 
385                 390                 395                 400 


Lys Gly Ser Thr Glu Glu Gly Ala Lys Leu Glu Lys Ala Lys Asn Ala 
                405                 410                 415     


Arg Val Lys Met Pro Glu Gln Glu Tyr Glu Phe Pro Glu Pro Arg Asn 
            420                 425                 430         


Leu Asn Asn Asn Met Arg Arg Pro Ser Ser Pro Arg Lys Trp Tyr Ser 
        435                 440                 445             


Pro Ile Lys Gly Lys Leu Asp Ala Leu Trp Val Leu Leu Arg Lys Gly 
    450                 455                 460                 


Tyr Asp Arg Val Ser Val Met Arg Pro Gln Pro Gly Asp Thr Gly Arg 
465                 470                 475                 480 


Cys Ile Asn Phe Thr Arg Val Lys Asn Asn Gln Pro Ala Lys Tyr Pro 
                485                 490                 495     


Leu Asn Asn Ala Tyr His Thr Ser Ser Pro Pro Pro Ala Pro Ile Tyr 
            500                 505                 510         


Thr Pro Pro Pro Pro Ala Pro His Cys Pro Pro Pro Pro Pro Ser Ala 
        515                 520                 525             


Pro Thr Pro Pro Ile Pro Ser Pro Pro Ser Thr Leu Pro Pro Pro Pro 
    530                 535                 540                 


Gln Ala Pro Pro Pro Asn Arg Ala Pro Pro Pro Ser Arg Pro Pro Pro 
545                 550                 555                 560 


Arg Pro Ser Val 
                


<210>  11
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  TEM825 mAb VH cDNA

<400>  11
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggacctc agtgaaggtc       60

tcctgcaagg ttcctggata caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac aacaaactac      180

gcacagaagt tccagggcag agtcacgatt accggggagg aatccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatacg      300

gactacatgt ttgactactg gggccaggga accctggtca ccgtgagctc a               351


<210>  12
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  TEM825 mAb VL cDNA

<400>  12
tcttctgagc tgactcagga ccctgttgtg tctgtggcct tgggagagac agtcagtatc       60

acatgccaag gagacaacct cagagacttt tatgcaagct ggtaccaaca gaagccagga      120

caggcccctc tactagtcat gtatggtaaa aacaggcggc cctcagggat cccagaccga      180

ttctctggct ccacctcagg aaacacactt tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg tagctcccgg gacaacagta agcatgtggt gttcggcggg      300

gggaccaagg tcaccgtcct a                                                321


<210>  13
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  TEM822 mAb VH cDNA

<400>  13
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttctggata caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatacg      300

gactacatgt ttgactactg gggccaggga accctggtca ccgtgagctc a               351


<210>  14
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  TEM822 mAb VL cDNA

<400>  14
tcttctgagc tgactcagga ccctgttgtg tctgtggcct tgggagagac agtcagtatc       60

acatgccaag gagacaacct cagagacttt tatgcaagct ggtaccaaca gaagccagga      120

caggcccctc tactagtcat gtatggtaaa aacaggcggc cctcagggat cccagaccga      180

ttctctggct ccacctcagg aaacacactt tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg tagctcccgg gacaacagta agcatgtggt gttcggcggg      300

gggaccaagg tcaccgtcct a                                                321


<210>  15
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  TEM830 mAb VH cDNA

<400>  15
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cgtgagactc       60

tcctgtgcag cctctggatt caccttcagt acctatacta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaatt atctcaaatg atggaagcaa taagtactac      180

gcagaccccg tgaggggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgt acgtggcagc      300

agctggtatc gcggaaattg gttcgacccc tggggccagg gaaccctggt caccgtgagc      360

tca                                                                    363


<210>  16
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  TEM830 mAb VL cDNA

<400>  16
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcgcttgcc gggcaagtca gaccattagt aggtatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtctcatca      180

aggttcagtg gcagtggatc tgggacagag ttcactctca ccatcagcag tctgcagcct      240

gaagattttg caacttattt ctgtcaacag acttacagtc ccccgatcac cttcggccaa      300

gggacacgac tggagattaa acga                                             324


<210>  17
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  TEM863 mAb VH cDNA

<400>  17
gaggtgcagc tggtggagac cggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta ccagtggtag cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcgggctgag atctgacgac actgccgtgt attactgtgt gagagatccg      300

ggttctccta agtggctggc cttcgacccc tggggccagg gcaccctggt caccgtgagc      360

tca                                                                    363


<210>  18
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  TEM863 mAb VL cDNA

<400>  18
gacatccagt tgacccagtc tccatcctcc ttgtctgctt ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtcg ggccattagt aggtatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtctcatca      180

aggttcagtg gcagtggatc tgggacagag ttcactctca ccatcagcag tctgcagcct      240

gaagattttg caacttattt ctgtcaacag acttacagtc ccccgatcac cttcggccaa      300

gggacacgac tggagattaa acgt                                             324


<210>  19
<211>  1667
<212>  DNA
<213>  Homo sapiens

<400>  19
atcatattta aaatctggga caaagaaccg tcgggacgga actccttcca ttgcaaaagc       60

tcggcgcggc ctcgggagct gcccggcggc cccggaccga ggcagccctc ccctttaaaa      120

gaagcggagg acaggattgg gatccttgaa acccgaaacc cagaaacagc atcggagcgg      180

aaaccagagg ggaaaccttg aactcctcca gacaattgct tccggggagt tgcgagggag      240

cgagggggaa taaaggaccc gcgaggaagg gcccgcggat ggcgcgtccc tgagggtcgt      300

ggcgagttcg cggagcgtgg gaaggagcgg accctgctct ccccgggctg cgggccatgg      360

ccacggcgga gcggagagcc ctcggcatcg gcttccagtg gctctctttg gccactctgg      420

tgctcatctg cgccgggcaa gggggacgca gggaggatgg gggtccagcc tgctacggcg      480

gatttgacct gtacttcatt ttggacaaat caggaagtgt gctgcaccac tggaatgaaa      540

tctattactt tgtggaacag ttggctcaca aattcatcag cccacagttg agaatgtcct      600

ttattgtttt ctccacccga ggaacaacct taatgaaact gacagaagac agagaacaaa      660

tccgtcaagg cctagaagaa ctccagaaag ttctgccagg aggagacact tacatgcatg      720

aaggatttga aagggccagt gagcagattt attatgaaaa cagacaaggg tacaggacag      780

ccagcgtcat cattgctttg actgatggag aactccatga agatctcttt ttctattcag      840

agagggaggc taataggtct cgagatcttg gtgcaattgt ttactgtgtt ggtgtgaaag      900

atttcaatga gacacagctg gcccggattg cggacagtaa ggatcatgtg tttcccgtga      960

atgacggctt tcaggctctg caaggcatca tccactcaat tttgaagaag tcctgcatcg     1020

aaattctagc agctgaacca tccaccatat gtgcaggaga gtcatttcaa gttgtcgtga     1080

gaggaaacgg cttccgacat gcccgcaacg tggacagggt cctctgcagc ttcaagatca     1140

atgactcggt cacactcaat gagaagccct tttctgtgga agatacttat ttactgtgtc     1200

cagcgcctat cttaaaagaa gttggcatga aagctgcact ccaggtcagc atgaacgatg     1260

gcctctcttt tatctccagt tctgtcatca tcaccaccac acactgttct gacggttcca     1320

tcctggccat cgccctgctg atcctgttcc tgctcctagc cctggctctc ctctggtggt     1380

tctggcccct ctgctgcact gtgattatca aggaggtccc tccaccccct gccgaggaga     1440

gtgaggaaaa taaaataaaa taacaagaag aagaaagaaa gaaatcccac agaaacagat     1500

aacctaacac agcccgtgca acgtatttta tacaatgctc tgaaaatcat agtctcaatc     1560

tagacagtct tttcctctag ttccctgtat tcaaatccca gtgtctaaca ttcaataaat     1620

agctatatga aatcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   1667


<210>  20
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Thr Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Thr Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Thr Arg Gly Thr Thr Leu Met Lys Leu Thr 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Thr Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Thr Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Thr Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Thr Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Thr Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Thr Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Thr Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Thr Thr Thr His Cys Ser Asp Gly 
305                 310                 315                 320 


Ser Ile Leu Ala Ile Ala Leu Leu Ile Leu Phe Leu Leu Leu Ala Leu 
                325                 330                 335     


Ala Leu Leu Trp Trp Phe Trp Pro Leu Cys Cys Thr Val Ile Ile Lys 
            340                 345                 350         


Glu Val Pro Pro Pro Pro Ala Glu Glu Ser Glu Glu Asn Lys Ile Lys 
        355                 360                 365             


<210>  21
<211>  2360
<212>  DNA
<213>  Homo sapiens

<400>  21
atcatattta aaatctggga caaagaaccg tcgggacgga actccttcca ttgcaaaagc       60

tcggcgcggc ctcgggagct gcccggcggc cccggaccga ggcagccctc ccctttaaaa      120

gaagcggagg acaggattgg gatccttgaa acccgaaacc cagaaacagc atcggagcgg      180

aaaccagagg ggaaaccttg aactcctcca gacaattgct tccggggagt tgcgagggag      240

cgagggggaa taaaggaccc gcgaggaagg gcccgcggat ggcgcgtccc tgagggtcgt      300

ggcgagttcg cggagcgtgg gaaggagcgg accctgctct ccccgggctg cgggccatgg      360

ccacggcgga gcggagagcc ctcggcatcg gcttccagtg gctctctttg gccactctgg      420

tgctcatctg cgccgggcaa gggggacgca gggaggatgg gggtccagcc tgctacggcg      480

gatttgacct gtacttcatt ttggacaaat caggaagtgt gctgcaccac tggaatgaaa      540

tctattactt tgtggaacag ttggctcaca aattcatcag cccacagttg agaatgtcct      600

ttattgtttt ctccacccga ggaacaacct taatgaaact gacagaagac agagaacaaa      660

tccgtcaagg cctagaagaa ctccagaaag ttctgccagg aggagacact tacatgcatg      720

aaggatttga aagggccagt gagcagattt attatgaaaa cagacaaggg tacaggacag      780

ccagcgtcat cattgctttg actgatggag aactccatga agatctcttt ttctattcag      840

agagggaggc taataggtct cgagatcttg gtgcaattgt ttactgtgtt ggtgtgaaag      900

atttcaatga gacacagctg gcccggattg cggacagtaa ggatcatgtg tttcccgtga      960

atgacggctt tcaggctctg caaggcatca tccactcaat tttgaagaag tcctgcatcg     1020

aaattctagc agctgaacca tccaccatat gtgcaggaga gtcatttcaa gttgtcgtga     1080

gaggaaacgg cttccgacat gcccgcaacg tggacagggt cctctgcagc ttcaagatca     1140

atgactcggt cacactcaat gagaagccct tttctgtgga agatacttat ttactgtgtc     1200

cagcgcctat cttaaaagaa gttggcatga aagctgcact ccaggtcagc atgaacgatg     1260

gcctctcttt tatctccagt tctgtcatca tcaccaccac acactgtagc ctccacaaaa     1320

ttgcatcagg ccccacaaca gctgcttgca tggaatagca gagaataccg cctgctccct     1380

ccggacagca cactcctgaa aacggggaga gaggagccaa acatgctcgg tttacacttt     1440

ccttatttac tgaatgagtg gagggcagag acaggcctgg agttacgcac actgagtgcc     1500

ccaacatgga aagaaacatc aggagggaca ggaaacgttc cctccttaac caacagtttt     1560

caagacctta ctggaggcac tttattggct acataatcac tccatgcggt gggcatcagg     1620

cagaatcctg gtgcagaccc aactttgagg tggaggattt cacagtttct ttattttgaa     1680

cttcccccag gctcccacta attcctctcc attctatcct cctccctttc ccacaaaaga     1740

aaacagaaag gagcagcagt gtttgatacc gtatcatcca gaggcctggt tctctcccat     1800

tatagggcaa acaagccctg gcaagatatt tcactcccgc cccatgccat gcattaaaaa     1860

tccaaaattg cctatattcc acctgccaag caagagatgc tttcattatt gaagttccaa     1920

atgtatacct ttgagaacag tgccttctcg tcttaaaaga gaggtcctca ttttgtgagt     1980

tgggagcaga gggaattaaa gaaagccatg atgcagggat ttggccattc aagccgggca     2040

gccttcagag aatgtcatcc ctaatgacac atgcccgaat gaaggagcgg ggctgagctt     2100

gtcctgcctt cgtattgaat gttgcctgtc tgcctcctta atagcgggcc tctgtgtgag     2160

catttgacaa gacttaaaac tattcattga agaaaatgga tgatccccca acaggaagat     2220

gcaaccccat gggctgcctg cttgaccaca gaagtgcttc cagctccagt tgctcatctg     2280

agaactcccc ccaccacttg ctgttaaaat tgttaaaatt aaaggccatg ttgattgatt     2340

ttttaaaaaa aaaaaaaaaa                                                 2360


<210>  22
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Thr Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Thr Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Thr Arg Gly Thr Thr Leu Met Lys Leu Thr 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Thr Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Thr Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Thr Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Thr Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Thr Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Thr Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Thr Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Thr Thr Thr His Cys Ser Leu His 
305                 310                 315                 320 


Lys Ile Ala Ser Gly Pro Thr Thr Ala Ala Cys Met Glu 
                325                 330             


