
                                SEQUENCE LISTING

<110> BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
      

<120> [ALPHA]1-ANTITRYPSIN COMPOSITIONS AND
  METHODS OF TREATING AUTOIMMUNE DISEASES
  

<130> 20225-0008WO1

<140> PCT/US2015/035385   
<141> 2015-06-11  

<150> US 62/010,741       
<151> 2014-06-11  

<160> 22

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1257
<212> DNA
<213> Homo sapiens

<400> 1
atgccgtctt ctgtctcgtg gggcatcctc ctgctggcag gcctgtgctg cctggtccct 60
gtctccctgg ctgaggatcc ccagggagat gctgcccaga agacagatac atcccaccat 120
gatcaggatc acccaacctt caacaagatc acccccaacc tggctgagtt cgccttcagc 180
ctataccgcc agctggcaca ccagtccaac agcaccaata tcttcttctc cccagtgagc 240
atcgctacag cctttgcaat gctctccctg gggaccaagg ctgacactca cgatgaaatc 300
ctggagggcc tgaatttcaa cctcacggag attccggagg ctcagatcca tgaaggcttc 360
caggaactcc tccgtaccct caaccagcca gacagccagc tccagctgac caccggcaat 420
ggcctgttcc tcagcgaggg cctgaagcta gtggataagt ttttggagga tgttaaaaag 480
ttgtaccact cagaagcctt cactgtcaac ttcggggaca ccgaagaggc caagaaacag 540
atcaacgatt acgtggagaa gggtactcaa gggaaaattg tggatttggt caaggagctt 600
gacagagaca cagtttttgc tctggtgaat tacatcttct ttaaaggcaa atgggagaga 660
ccctttgaag tcaaggacac cgaggaagag gacttccacg tggaccaggt gaccaccgtg 720
aaggtgccta tgatgaagcg tttaggcatg tttaacatcc agcactgtaa gaagctgtcc 780
agctgggtgc tgctgatgaa atacctgggc aatgccaccg ccatcttctt cctgcctgat 840
gaggggaaac tacagcacct ggaaaatgaa ctcacccacg atatcatcac caagttcctg 900
gaaaatgaag acagaaggtc tgccagctta catttaccca aactgtccat tactggaacc 960
tatgatctga agagcgtcct gggtcaactg ggcatcacta aggtcttcag caatggggct 1020
gacctctccg gggtcacaga ggaggcaccc ctgaagctct ccaaggccgt gcataaggct 1080
gtgctgacca tcgacgagaa agggactgaa gctgctgggg ccatgttttt agaggccata 1140
cccatgtcta tcccccccga ggtcaagttc aacaaaccct ttgtcttctt aatgattgaa 1200
caaaatacca agtctcccct cttcatggga aaagtggtga atcccaccca aaaataa    1257

<210> 2
<211> 418
<212> PRT
<213> Homo sapiens

<400> 2
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
 1               5                  10                  15      
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
            20                  25                  30          
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
        35                  40                  45              
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
    50                  55                  60                  
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
65                  70                  75                  80  
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                85                  90                  95      
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro
            100                 105                 110         
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn
        115                 120                 125             
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu
    130                 135                 140                 
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys
145                 150                 155                 160 
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu
                165                 170                 175     
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys
            180                 185                 190         
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu
        195                 200                 205             
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val
    210                 215                 220                 
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val
225                 230                 235                 240 
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys
                245                 250                 255     
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala
            260                 265                 270         
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu
        275                 280                 285             
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp
    290                 295                 300                 
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr
305                 310                 315                 320 
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe
                325                 330                 335     
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys
            340                 345                 350         
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly
        355                 360                 365             
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile
    370                 375                 380                 
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu
385                 390                 395                 400 
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr
                405                 410                 415     
Gln Lys
        


<210> 3
<211> 681
<212> DNA
<213> Homo sapiens

<400> 3
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc 60
ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 120
tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 180
ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 240
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 300
tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 360
gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag 420
aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 480
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 540
gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg 600
aacgtcttct catgctccgt gatgcacgag gctctgcaca accactacac gcagaagagc 660
ctctccctgt ctccgggtaa a                                           681

<210> 4
<211> 227
<212> PRT
<213> Homo sapiens

<400> 4
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
 1               5                  10                  15      
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
            20                  25                  30          
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
        35                  40                  45              
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
    50                  55                  60                  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
65                  70                  75                  80  
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
                85                  90                  95      
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
        115                 120                 125             
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
    130                 135                 140                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
145                 150                 155                 160 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
                165                 170                 175     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
            180                 185                 190         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
        195                 200                 205             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
    210                 215                 220                 
Pro Gly Lys
225         


<210> 5
<211> 681
<212> DNA
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 5
gacaaaactc acacatgccc accgtgccca gcacctgaac tcgagggggg accgtcagtc 60
ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 120
tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 180
ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 240
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggcgtacaag 300
gccgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 360
gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag 420
aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 480
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 540
gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg 600
aacgtcttct catgctccgt gatgcacgag gctctgcaca accactacac gcagaagagc 660
ctctccctgt ctccgggtaa a                                           681

<210> 6
<211> 227
<212> PRT
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 6
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Glu Gly
 1               5                  10                  15      
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
            20                  25                  30          
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
        35                  40                  45              
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
    50                  55                  60                  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
65                  70                  75                  80  
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
                85                  90                  95      
Lys Ala Tyr Lys Ala Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
        115                 120                 125             
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
    130                 135                 140                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
145                 150                 155                 160 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
                165                 170                 175     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
            180                 185                 190         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
        195                 200                 205             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
    210                 215                 220                 
Pro Gly Lys
225         


<210> 7
<211> 1956
<212> DNA
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 7
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg 60
gatatcgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 120
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 180
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 240
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 300
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 360
tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 420
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg 480
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 540
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 600
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 660
caggggaacg tcttctcatg ctccgtgatg cacgaggctc tgcacaacca ctacacgcag 720
aagagcctct ccctgtctcc gggtaaacca tggggtggag gcggttcagg cggaggtggc 780
tctagatctg ctgcccagaa gacagataca tcccaccatg atcaggatca cccaaccttc 840
aacaagatca cccccaacct ggctgagttc gccttcagcc tataccgcca gctggcacac 900
cagtccaaca gcaccaatat cttcttctcc ccagtgagca tcgctacagc ctttgcaatg 960
ctctccctgg ggaccaaggc tgacactcac gatgaaatcc tggagggcct gaatttcaac 1020
ctcacggaga ttccggaggc tcagatccat gaaggcttcc aggaactcct ccgtaccctc 1080
aaccagccag acagccagct ccagctgacc accggcaatg gcctgttcct cagcgagggc 1140
ctgaagctag tggataagtt tttggaggat gttaaaaagt tgtaccactc agaagccttc 1200
actgtcaact tcggggacac cgaagaggcc aagaaacaga tcaacgatta cgtggagaag 1260
ggtactcaag ggaaaattgt ggatttggtc aaggagcttg acagagacac agtttttgct 1320
ctggtgaatt acatcttctt taaaggcaaa tgggagagac cctttgaagt caaggacacc 1380
gaggaagagg acttccacgt ggaccaggtg accaccgtga aggtgcctat gatgaagcgt 1440
ttaggcatgt ttaacatcca gcactgtaag aagctgtcca gctgggtgct gctgatgaaa 1500
tacctgggca atgccaccgc catcttcttc ctgcctgatg aggggaaact acagcacctg 1560
gaaaatgaac tcacccacga tatcatcacc aagttcctgg aaaatgaaga cagaaggtct 1620
gccagcttac atttacccaa actgtccatt actggaacct atgatctgaa gagcgtcctg 1680
ggtcaactgg gcatcactaa ggtcttcagc aatggggctg acctctccgg ggtcacagag 1740
gaggcacccc tgaagctctc caaggccgtg cataaggctg tgctgaccat cgacgagaaa 1800
gggactgaag ctgctggggc catgttttta gaggccatac ccatgtctat cccccccgag 1860
gtcaagttca acaaaccctt tgtcttctta atgattgaac aaaataccaa gtctcccctc 1920
ttcatgggaa aagtggtgaa tcccacccaa aaataa                           1956

<210> 8
<211> 651
<212> PRT
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 8
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Asp Ile Asp Lys Thr His Thr Cys Pro Pro Cys Pro
            20                  25                  30          
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
        35                  40                  45              
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
    50                  55                  60                  
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
65                  70                  75                  80  
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                85                  90                  95      
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
            100                 105                 110         
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
        115                 120                 125             
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
    130                 135                 140                 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
145                 150                 155                 160 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                165                 170                 175     
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
            180                 185                 190         
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
        195                 200                 205             
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
    210                 215                 220                 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
225                 230                 235                 240 
Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Trp Gly Gly Gly Gly Ser
                245                 250                 255     
Gly Gly Gly Gly Ser Arg Ser Ala Ala Gln Lys Thr Asp Thr Ser His
            260                 265                 270         
His Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala
        275                 280                 285             
Glu Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser
    290                 295                 300                 
Thr Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met
305                 310                 315                 320 
Leu Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly
                325                 330                 335     
Leu Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly
            340                 345                 350         
Phe Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln
        355                 360                 365             
Leu Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val
    370                 375                 380                 
Asp Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe
385                 390                 395                 400 
Thr Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp
                405                 410                 415     
Tyr Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu
            420                 425                 430         
Leu Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys
        435                 440                 445             
Gly Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp
    450                 455                 460                 
Phe His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg
465                 470                 475                 480 
Leu Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val
                485                 490                 495     
Leu Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro
            500                 505                 510         
Asp Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile
        515                 520                 525             
Ile Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His
    530                 535                 540                 
Leu Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu
545                 550                 555                 560 
Gly Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser
                565                 570                 575     
Gly Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys
            580                 585                 590         
Ala Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met
        595                 600                 605             
Phe Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn
    610                 615                 620                 
Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu
625                 630                 635                 640 
Phe Met Gly Lys Val Val Asn Pro Thr Gln Lys
                645                 650     


<210> 9
<211> 1980
<212> DNA
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 9
atgccgtctt ctgtctcgtg gggcatcctc ctgctggcag gcctgtgctg cctggtccct 60
gtctccctgg ctgaggatcc ccagggagat gctgcccaga agacagatac atcccaccat 120
gatcaggatc acccaacctt caacaagatc acccccaacc tggctgagtt cgccttcagc 180
ctataccgcc agctggcaca ccagtccaac agcaccaata tcttcttctc cccagtgagc 240
atcgctacag cctttgcaat gctctccctg gggaccaagg ctgacactca cgatgaaatc 300
ctggagggcc tgaatttcaa cctcacggag attccggagg ctcagatcca tgaaggcttc 360
caggaactcc tccgtaccct caaccagcca gacagccagc tccagctgac caccggcaat 420
ggcctgttcc tcagcgaggg cctgaagcta gtggataagt ttttggagga tgttaaaaag 480
ttgtaccact cagaagcctt cactgtcaac ttcggggaca ccgaagaggc caagaaacag 540
atcaacgatt acgtggagaa gggtactcaa gggaaaattg tggatttggt caaggagctt 600
gacagagaca cagtttttgc tctggtgaat tacatcttct ttaaaggcaa atgggagaga 660
ccctttgaag tcaaggacac cgaggaagag gacttccacg tggaccaggt gaccaccgtg 720
aaggtgccta tgatgaagcg tttaggcatg tttaacatcc agcactgtaa gaagctgtcc 780
agctgggtgc tgctgatgaa atacctgggc aatgccaccg ccatcttctt cctgcctgat 840
gaggggaaac tacagcacct ggaaaatgaa ctcacccacg atatcatcac caagttcctg 900
gaaaatgaag acagaaggtc tgccagctta catttaccca aactgtccat tactggaacc 960
tatgatctga agagcgtcct gggtcaactg ggcatcacta aggtcttcag caatggggct 1020
gacctctccg gggtcacaga ggaggcaccc ctgaagctct ccaaggccgt gcataaggct 1080
gtgctgacca tcgacgagaa agggactgaa gctgctgggg ccatgttttt agaggccata 1140
cccatgtcta tcccccccga ggtcaagttc aacaaaccct ttgtcttctt aatgattgaa 1200
caaaatacca agtctcccct cttcatggga aaagtggtga atcccaccca aaaaccatgg 1260
agaggtccta cgatcaagcc ctgcccgcct agatctgaca aaactcacac atgcccaccg 1320
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 1380
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 1440
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 1500
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 1560
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 1620
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 1680
tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg 1740
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 1800
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 1860
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 1920
cacgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaataa 1980


<210> 10
<211> 659
<212> PRT
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 10
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
 1               5                  10                  15      
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
            20                  25                  30          
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
        35                  40                  45              
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
    50                  55                  60                  
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
65                  70                  75                  80  
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                85                  90                  95      
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro
            100                 105                 110         
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn
        115                 120                 125             
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu
    130                 135                 140                 
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys
145                 150                 155                 160 
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu
                165                 170                 175     
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys
            180                 185                 190         
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu
        195                 200                 205             
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val
    210                 215                 220                 
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val
225                 230                 235                 240 
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys
                245                 250                 255     
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala
            260                 265                 270         
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu
        275                 280                 285             
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp
    290                 295                 300                 
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr
305                 310                 315                 320 
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe
                325                 330                 335     
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys
            340                 345                 350         
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly
        355                 360                 365             
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile
    370                 375                 380                 
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu
385                 390                 395                 400 
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr
                405                 410                 415     
Gln Lys Pro Trp Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Arg Ser
            420                 425                 430         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        435                 440                 445             
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    450                 455                 460                 
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
465                 470                 475                 480 
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                485                 490                 495     
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            500                 505                 510         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        515                 520                 525             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    530                 535                 540                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
545                 550                 555                 560 
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
                565                 570                 575     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            580                 585                 590         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        595                 600                 605             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    610                 615                 620                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
625                 630                 635                 640 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                645                 650                 655     
Pro Gly Lys
            


<210> 11
<211> 1995
<212> DNA
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 11
atgccgtctt ctgtctcgtg gggcatcctc ctgctggcag gcctgtgctg cctggtccct 60
gtctccctgg ctgaggatcc ccagggagat gctgcccaga agacagatac atcccaccat 120
gatcaggatc acccaacctt caacaagatc acccccaacc tggctgagtt cgccttcagc 180
ctataccgcc agctggcaca ccagtccaac agcaccaata tcttcttctc cccagtgagc 240
atcgctacag cctttgcaat gctctccctg gggaccaagg ctgacactca cgatgaaatc 300
ctggagggcc tgaatttcaa cctcacggag attccggagg ctcagatcca tgaaggcttc 360
caggaactcc tccgtaccct caaccagcca gacagccagc tccagctgac caccggcaat 420
ggcctgttcc tcagcgaggg cctgaagcta gtggataagt ttttggagga tgttaaaaag 480
ttgtaccact cagaagcctt cactgtcaac ttcggggaca ccgaagaggc caagaaacag 540
atcaacgatt acgtggagaa gggtactcaa gggaaaattg tggatttggt caaggagctt 600
gacagagaca cagtttttgc tctggtgaat tacatcttct ttaaaggcaa atgggagaga 660
ccctttgaag tcaaggacac cgaggaagag gacttccacg tggaccaggt gaccaccgtg 720
aaggtgccta tgatgaagcg tttaggcatg tttaacatcc agcactgtaa gaagctgtcc 780
agctgggtgc tgctgatgaa atacctgggc aatgccaccg ccatcttctt cctgcctgat 840
gaggggaaac tacagcacct ggaaaatgaa ctcacccacg atatcatcac caagttcctg 900
gaaaatgaag acagaaggtc tgccagctta catttaccca aactgtccat tactggaacc 960
tatgatctga agagcgtcct gggtcaactg ggcatcacta aggtcttcag caatggggct 1020
gacctctccg gggtcacaga ggaggcaccc ctgaagctct ccaaggccgt gcataaggct 1080
gtgctgacca tcgacgagaa agggactgaa gctgctgggg ccatgttttt agaggccata 1140
cccatgtcta tcccccccga ggtcaagttc aacaaaccct ttgtcttctt aatgattgaa 1200
caaaatacca agtctcccct cttcatggga aaagtggtga atcccaccca aaaaccatgg 1260
ggtggaggcg gttcaagagg tcctacgatc aagccctgcc cgcctagatc tgacaaaact 1320
cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc 1380
cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1440
gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1500
gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1560
agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc 1620
tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1680
cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc 1740
agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 1800
aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1860
ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 1920
tcatgctccg tgatgcacga ggctctgcac aaccactaca cgcagaagag cctctccctg 1980
tctccgggta aataa                                                  1995

<210> 12
<211> 664
<212> PRT
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 12
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
 1               5                  10                  15      
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
            20                  25                  30          
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
        35                  40                  45              
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
    50                  55                  60                  
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
65                  70                  75                  80  
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                85                  90                  95      
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro
            100                 105                 110         
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn
        115                 120                 125             
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu
    130                 135                 140                 
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys
145                 150                 155                 160 
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu
                165                 170                 175     
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys
            180                 185                 190         
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu
        195                 200                 205             
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val
    210                 215                 220                 
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val
225                 230                 235                 240 
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys
                245                 250                 255     
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala
            260                 265                 270         
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu
        275                 280                 285             
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp
    290                 295                 300                 
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr
305                 310                 315                 320 
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe
                325                 330                 335     
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys
            340                 345                 350         
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly
        355                 360                 365             
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile
    370                 375                 380                 
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu
385                 390                 395                 400 
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr
                405                 410                 415     
Gln Lys Pro Trp Gly Gly Gly Gly Ser Arg Gly Pro Thr Ile Lys Pro
            420                 425                 430         
Cys Pro Pro Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
        435                 440                 445             
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
    450                 455                 460                 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
465                 470                 475                 480 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
                485                 490                 495     
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
            500                 505                 510         
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
        515                 520                 525             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
    530                 535                 540                 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
545                 550                 555                 560 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
                565                 570                 575     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
            580                 585                 590         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
        595                 600                 605             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
    610                 615                 620                 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
625                 630                 635                 640 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                645                 650                 655     
Ser Leu Ser Leu Ser Pro Gly Lys
            660                 


<210> 13
<211> 1956
<212> DNA
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 13
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg 60
gatatcgaca aaactcacac atgcccaccg tgcccagcac ctgaactcga ggggggaccg 120
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 180
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 240
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 300
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggcg 360
tacaaggccg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 420
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg 480
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 540
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 600
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 660
caggggaacg tcttctcatg ctccgtgatg cacgaggctc tgcacaacca ctacacgcag 720
aagagcctct ccctgtctcc gggtaaacca tggggtggag gcggttcagg cggaggtggc 780
tctagatctg ctgcccagaa gacagataca tcccaccatg atcaggatca cccaaccttc 840
aacaagatca cccccaacct ggctgagttc gccttcagcc tataccgcca gctggcacac 900
cagtccaaca gcaccaatat cttcttctcc ccagtgagca tcgctacagc ctttgcaatg 960
ctctccctgg ggaccaaggc tgacactcac gatgaaatcc tggagggcct gaatttcaac 1020
ctcacggaga ttccggaggc tcagatccat gaaggcttcc aggaactcct ccgtaccctc 1080
aaccagccag acagccagct ccagctgacc accggcaatg gcctgttcct cagcgagggc 1140
ctgaagctag tggataagtt tttggaggat gttaaaaagt tgtaccactc agaagccttc 1200
actgtcaact tcggggacac cgaagaggcc aagaaacaga tcaacgatta cgtggagaag 1260
ggtactcaag ggaaaattgt ggatttggtc aaggagcttg acagagacac agtttttgct 1320
ctggtgaatt acatcttctt taaaggcaaa tgggagagac cctttgaagt caaggacacc 1380
gaggaagagg acttccacgt ggaccaggtg accaccgtga aggtgcctat gatgaagcgt 1440
ttaggcatgt ttaacatcca gcactgtaag aagctgtcca gctgggtgct gctgatgaaa 1500
tacctgggca atgccaccgc catcttcttc ctgcctgatg aggggaaact acagcacctg 1560
gaaaatgaac tcacccacga tatcatcacc aagttcctgg aaaatgaaga cagaaggtct 1620
gccagcttac atttacccaa actgtccatt actggaacct atgatctgaa gagcgtcctg 1680
ggtcaactgg gcatcactaa ggtcttcagc aatggggctg acctctccgg ggtcacagag 1740
gaggcacccc tgaagctctc caaggccgtg cataaggctg tgctgaccat cgacgagaaa 1800
gggactgaag ctgctggggc catgttttta gaggccatac ccatgtctat cccccccgag 1860
gtcaagttca acaaaccctt tgtcttctta atgattgaac aaaataccaa gtctcccctc 1920
ttcatgggaa aagtggtgaa tcccacccaa aaataa                           1956

<210> 14
<211> 651
<212> PRT
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 14
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Asp Ile Asp Lys Thr His Thr Cys Pro Pro Cys Pro
            20                  25                  30          
Ala Pro Glu Leu Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
        35                  40                  45              
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
    50                  55                  60                  
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
65                  70                  75                  80  
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                85                  90                  95      
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
            100                 105                 110         
Gln Asp Trp Leu Asn Gly Lys Ala Tyr Lys Ala Ala Val Ser Asn Lys
        115                 120                 125             
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
    130                 135                 140                 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
145                 150                 155                 160 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                165                 170                 175     
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
            180                 185                 190         
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
        195                 200                 205             
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
    210                 215                 220                 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
225                 230                 235                 240 
Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Trp Gly Gly Gly Gly Ser
                245                 250                 255     
Gly Gly Gly Gly Ser Arg Ser Ala Ala Gln Lys Thr Asp Thr Ser His
            260                 265                 270         
His Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala
        275                 280                 285             
Glu Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser
    290                 295                 300                 
Thr Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met
305                 310                 315                 320 
Leu Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly
                325                 330                 335     
Leu Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly
            340                 345                 350         
Phe Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln
        355                 360                 365             
Leu Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val
    370                 375                 380                 
Asp Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe
385                 390                 395                 400 
Thr Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp
                405                 410                 415     
Tyr Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu
            420                 425                 430         
Leu Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys
        435                 440                 445             
Gly Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp
    450                 455                 460                 
Phe His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg
465                 470                 475                 480 
Leu Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val
                485                 490                 495     
Leu Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro
            500                 505                 510         
Asp Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile
        515                 520                 525             
Ile Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His
    530                 535                 540                 
Leu Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu
545                 550                 555                 560 
Gly Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser
                565                 570                 575     
Gly Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys
            580                 585                 590         
Ala Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met
        595                 600                 605             
Phe Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn
    610                 615                 620                 
Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu
625                 630                 635                 640 
Phe Met Gly Lys Val Val Asn Pro Thr Gln Lys
                645                 650     


<210> 15
<211> 1980
<212> DNA
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 15
atgccgtctt ctgtctcgtg gggcatcctc ctgctggcag gcctgtgctg cctggtccct 60
gtctccctgg ctgaggatcc ccagggagat gctgcccaga agacagatac atcccaccat 120
gatcaggatc acccaacctt caacaagatc acccccaacc tggctgagtt cgccttcagc 180
ctataccgcc agctggcaca ccagtccaac agcaccaata tcttcttctc cccagtgagc 240
atcgctacag cctttgcaat gctctccctg gggaccaagg ctgacactca cgatgaaatc 300
ctggagggcc tgaatttcaa cctcacggag attccggagg ctcagatcca tgaaggcttc 360
caggaactcc tccgtaccct caaccagcca gacagccagc tccagctgac caccggcaat 420
ggcctgttcc tcagcgaggg cctgaagcta gtggataagt ttttggagga tgttaaaaag 480
ttgtaccact cagaagcctt cactgtcaac ttcggggaca ccgaagaggc caagaaacag 540
atcaacgatt acgtggagaa gggtactcaa gggaaaattg tggatttggt caaggagctt 600
gacagagaca cagtttttgc tctggtgaat tacatcttct ttaaaggcaa atgggagaga 660
ccctttgaag tcaaggacac cgaggaagag gacttccacg tggaccaggt gaccaccgtg 720
aaggtgccta tgatgaagcg tttaggcatg tttaacatcc agcactgtaa gaagctgtcc 780
agctgggtgc tgctgatgaa atacctgggc aatgccaccg ccatcttctt cctgcctgat 840
gaggggaaac tacagcacct ggaaaatgaa ctcacccacg atatcatcac caagttcctg 900
gaaaatgaag acagaaggtc tgccagctta catttaccca aactgtccat tactggaacc 960
tatgatctga agagcgtcct gggtcaactg ggcatcacta aggtcttcag caatggggct 1020
gacctctccg gggtcacaga ggaggcaccc ctgaagctct ccaaggccgt gcataaggct 1080
gtgctgacca tcgacgagaa agggactgaa gctgctgggg ccatgttttt agaggccata 1140
cccatgtcta tcccccccga ggtcaagttc aacaaaccct ttgtcttctt aatgattgaa 1200
caaaatacca agtctcccct cttcatggga aaagtggtga atcccaccca aaaaccatgg 1260
agaggtccta cgatcaagcc ctgcccgcct agatctgaca aaactcacac atgcccaccg 1320
tgcccagcac ctgaactcga ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 1380
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 1440
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 1500
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 1560
ctgcaccagg actggctgaa tggcaaggcg tacaaggccg cggtctccaa caaagccctc 1620
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 1680
tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg 1740
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 1800
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 1860
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 1920
cacgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaataa 1980


<210> 16
<211> 659
<212> PRT
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 16
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
 1               5                  10                  15      
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
            20                  25                  30          
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
        35                  40                  45              
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
    50                  55                  60                  
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
65                  70                  75                  80  
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                85                  90                  95      
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro
            100                 105                 110         
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn
        115                 120                 125             
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu
    130                 135                 140                 
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys
145                 150                 155                 160 
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu
                165                 170                 175     
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys
            180                 185                 190         
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu
        195                 200                 205             
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val
    210                 215                 220                 
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val
225                 230                 235                 240 
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys
                245                 250                 255     
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala
            260                 265                 270         
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu
        275                 280                 285             
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp
    290                 295                 300                 
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr
305                 310                 315                 320 
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe
                325                 330                 335     
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys
            340                 345                 350         
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly
        355                 360                 365             
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile
    370                 375                 380                 
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu
385                 390                 395                 400 
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr
                405                 410                 415     
Gln Lys Pro Trp Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Arg Ser
            420                 425                 430         
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Glu Gly
        435                 440                 445             
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    450                 455                 460                 
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
465                 470                 475                 480 
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                485                 490                 495     
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            500                 505                 510         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        515                 520                 525             
Lys Ala Tyr Lys Ala Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    530                 535                 540                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
545                 550                 555                 560 
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
                565                 570                 575     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            580                 585                 590         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        595                 600                 605             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    610                 615                 620                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
625                 630                 635                 640 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                645                 650                 655     
Pro Gly Lys
            


<210> 17
<211> 1995
<212> DNA
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 17
atgccgtctt ctgtctcgtg gggcatcctc ctgctggcag gcctgtgctg cctggtccct 60
gtctccctgg ctgaggatcc ccagggagat gctgcccaga agacagatac atcccaccat 120
gatcaggatc acccaacctt caacaagatc acccccaacc tggctgagtt cgccttcagc 180
ctataccgcc agctggcaca ccagtccaac agcaccaata tcttcttctc cccagtgagc 240
atcgctacag cctttgcaat gctctccctg gggaccaagg ctgacactca cgatgaaatc 300
ctggagggcc tgaatttcaa cctcacggag attccggagg ctcagatcca tgaaggcttc 360
caggaactcc tccgtaccct caaccagcca gacagccagc tccagctgac caccggcaat 420
ggcctgttcc tcagcgaggg cctgaagcta gtggataagt ttttggagga tgttaaaaag 480
ttgtaccact cagaagcctt cactgtcaac ttcggggaca ccgaagaggc caagaaacag 540
atcaacgatt acgtggagaa gggtactcaa gggaaaattg tggatttggt caaggagctt 600
gacagagaca cagtttttgc tctggtgaat tacatcttct ttaaaggcaa atgggagaga 660
ccctttgaag tcaaggacac cgaggaagag gacttccacg tggaccaggt gaccaccgtg 720
aaggtgccta tgatgaagcg tttaggcatg tttaacatcc agcactgtaa gaagctgtcc 780
agctgggtgc tgctgatgaa atacctgggc aatgccaccg ccatcttctt cctgcctgat 840
gaggggaaac tacagcacct ggaaaatgaa ctcacccacg atatcatcac caagttcctg 900
gaaaatgaag acagaaggtc tgccagctta catttaccca aactgtccat tactggaacc 960
tatgatctga agagcgtcct gggtcaactg ggcatcacta aggtcttcag caatggggct 1020
gacctctccg gggtcacaga ggaggcaccc ctgaagctct ccaaggccgt gcataaggct 1080
gtgctgacca tcgacgagaa agggactgaa gctgctgggg ccatgttttt agaggccata 1140
cccatgtcta tcccccccga ggtcaagttc aacaaaccct ttgtcttctt aatgattgaa 1200
caaaatacca agtctcccct cttcatggga aaagtggtga atcccaccca aaaaccatgg 1260
ggtggaggcg gttcaagagg tcctacgatc aagccctgcc cgcctagatc tgacaaaact 1320
cacacatgcc caccgtgccc agcacctgaa ctcgaggggg gaccgtcagt cttcctcttc 1380
cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1440
gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1500
gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1560
agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggcgtacaa ggccgcggtc 1620
tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1680
cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc 1740
agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 1800
aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1860
ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 1920
tcatgctccg tgatgcacga ggctctgcac aaccactaca cgcagaagag cctctccctg 1980
tctccgggta aataa                                                  1995

<210> 18
<211> 664
<212> PRT
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 18
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
 1               5                  10                  15      
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
            20                  25                  30          
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
        35                  40                  45              
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
    50                  55                  60                  
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
65                  70                  75                  80  
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                85                  90                  95      
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro
            100                 105                 110         
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn
        115                 120                 125             
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu
    130                 135                 140                 
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys
145                 150                 155                 160 
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu
                165                 170                 175     
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys
            180                 185                 190         
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu
        195                 200                 205             
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val
    210                 215                 220                 
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val
225                 230                 235                 240 
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys
                245                 250                 255     
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala
            260                 265                 270         
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu
        275                 280                 285             
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp
    290                 295                 300                 
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr
305                 310                 315                 320 
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe
                325                 330                 335     
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys
            340                 345                 350         
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly
        355                 360                 365             
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile
    370                 375                 380                 
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu
385                 390                 395                 400 
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr
                405                 410                 415     
Gln Lys Pro Trp Gly Gly Gly Gly Ser Arg Gly Pro Thr Ile Lys Pro
            420                 425                 430         
Cys Pro Pro Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
        435                 440                 445             
Pro Glu Leu Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
    450                 455                 460                 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
465                 470                 475                 480 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
                485                 490                 495     
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
            500                 505                 510         
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
        515                 520                 525             
Asp Trp Leu Asn Gly Lys Ala Tyr Lys Ala Ala Val Ser Asn Lys Ala
    530                 535                 540                 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
545                 550                 555                 560 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
                565                 570                 575     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
            580                 585                 590         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
        595                 600                 605             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
    610                 615                 620                 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
625                 630                 635                 640 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                645                 650                 655     
Ser Leu Ser Leu Ser Pro Gly Lys
            660                 


<210> 19
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 19
ccttagatct atgccgtctt ctgtctcgtg gggcatcc                         38

<210> 20
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 20
ccttgctagc ttatttttgg gtgggattca ccacttttcc c                     41

<210> 21
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 21
ccttgaattc atgccgtctt ctgtctcgtg gggcatcc                         38

<210> 22
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> laboratory-synthesized sequence

<400> 22
ccttccatgg tttttgggtg ggattcacca cttttccc                         38
