                               SEQUENCE LISTING

<110> AMGEN INC.
      SANTA MARIA BIOTHERAPEUTICS, INC.
 
<120> FORMULATED RECEPTOR POLYPEPTIDES AND RELATED METHODS

<130> 29957-29502 PCT

<140> PCT/US2015/035818
<141> 2015-06-15

<150> 62/142,812
<151> 2015-04-03

<150> 62/058,789
<151> 2014-10-02

<150> 62/047,995
<151> 2014-09-09

<150> 61/012,104
<151> 2014-06-13

<160> 53    

<170> PatentIn version 3.5

<210> 1
<211> 402
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(402)

<400> 1
atg acg gcg ccc tgg gtg gcc ctc gcc ctc ctc tgg gga tcg ctg tgc         48
Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys           
1               5                   10                  15                

gcc ggc tct ggg cgt ggg gag gct gag aca cgg gag tgc atc tac tac         96
Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr           
            20                  25                  30                    

aac gcc aac tgg gag ctg gag cgc acc aac cag agc ggc ctg gag cgc        144
Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg           
        35                  40                  45                        

tgc gaa ggc gag cag gac aag cgg ctg cac tgc tac gcc tcc tgg cgc        192
Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg           
    50                  55                  60                            

aac agc tct ggc acc atc gag ctc gtg aag aag ggc tgc tgg cta gat        240
Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp           
65                  70                  75                  80            

gac ttc aac tgc tac gat agg cag gag tgt gtg gcc act gag gag aac        288
Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn           
                85                  90                  95                

ccc cag gtg tac ttc tgc tgc tgt gaa ggc aac ttc tgc aac gag cgc        336
Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg           
            100                 105                 110                   

ttc act cat ttg cca gag gct ggg ggc ccg gaa gtc acg tac gag cca        384
Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro           
        115                 120                 125                       

ccc ccg aca gcc ccc acc                                                402
Pro Pro Thr Ala Pro Thr                                                   
    130                                                                   


<210> 2
<211> 134
<212> PRT
<213> Homo sapiens

<400> 2
Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          


Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              


Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  


Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  


Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      


Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         


Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             


Pro Pro Thr Ala Pro Thr 
    130                 


<210> 3
<211> 387
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(387)

<400> 3
atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt         48
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly           
1               5                   10                  15                

gtc cag tgt gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag         96
Val Gln Cys Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu           
            20                  25                  30                    

ctg gag cgc acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag        144
Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln           
        35                  40                  45                        

gac aag cgg ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc        192
Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr           
    50                  55                  60                            

atc gag ctc gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac        240
Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr           
65                  70                  75                  80            

gat agg cag gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc        288
Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe           
                85                  90                  95                

tgc tgc tgt gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca        336
Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro           
            100                 105                 110                   

gag gct ggg ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc        384
Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro           
        115                 120                 125                       

acc                                                                    387
Thr                                                                       
                                                                          


<210> 4
<211> 129
<212> PRT
<213> Homo sapiens

<400> 4
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 
            20                  25                  30          


Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 
        35                  40                  45              


Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 
    50                  55                  60                  


Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 
65                  70                  75                  80  


Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 
                85                  90                  95      


Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 
            100                 105                 110         


Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 
        115                 120                 125             


Thr 
  


<210> 5
<211> 330
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(330)

<400> 5
gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag ctg gag cgc         48
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg           
1               5                   10                  15                

acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg         96
Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg           
            20                  25                  30                    

ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc        144
Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu           
        35                  40                  45                        

gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag        192
Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln           
    50                  55                  60                            

gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt        240
Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys           
65                  70                  75                  80            

gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg        288
Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly           
                85                  90                  95                

ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc                330
Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr                   
            100                 105                 110                   


<210> 6
<211> 110
<212> PRT
<213> Homo sapiens

<400> 6
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210> 7
<211> 1071
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(1071)

<400> 7
atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt         48
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly           
1               5                   10                  15                

gtc cag tgt gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag         96
Val Gln Cys Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu           
            20                  25                  30                    

ctg gag cgc acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag        144
Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln           
        35                  40                  45                        

gac aag cgg ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc        192
Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr           
    50                  55                  60                            

atc gag ctc gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac        240
Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr           
65                  70                  75                  80            

gat agg cag gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc        288
Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe           
                85                  90                  95                

tgc tgc tgt gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca        336
Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro           
            100                 105                 110                   

gag gct ggg ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc        384
Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro           
        115                 120                 125                       

acc gga ggg gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct        432
Thr Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro           
    130                 135                 140                           

gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc        480
Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr           
145                 150                 155                 160           

ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg        528
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val           
                165                 170                 175               

agc cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg        576
Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val           
            180                 185                 190                   

gag gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc aac agc        624
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser           
        195                 200                 205                       

acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg        672
Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu           
    210                 215                 220                           

aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc        720
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala           
225                 230                 235                 240           

ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca        768
Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro           
                245                 250                 255               

cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag        816
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln           
            260                 265                 270                   

gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc        864
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala           
        275                 280                 285                       

gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc aca        912
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr           
    290                 295                 300                           

cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc        960
Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu           
305                 310                 315                 320           

acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc       1008
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser           
                325                 330                 335               

gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc       1056
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser           
            340                 345                 350                   

ctg tct ccg ggt aaa                                                   1071
Leu Ser Pro Gly Lys                                                       
        355                                                               


<210> 8
<211> 357
<212> PRT
<213> Homo sapiens

<400> 8
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 
            20                  25                  30          


Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 
        35                  40                  45              


Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 
    50                  55                  60                  


Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 
65                  70                  75                  80  


Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 
                85                  90                  95      


Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 
            100                 105                 110         


Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
    130                 135                 140                 


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
        195                 200                 205             


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly Lys 
        355         


<210> 9
<211> 1014
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(1014)

<400> 9
gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag ctg gag cgc         48
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg           
1               5                   10                  15                

acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg         96
Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg           
            20                  25                  30                    

ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc        144
Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu           
        35                  40                  45                        

gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag        192
Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln           
    50                  55                  60                            

gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt        240
Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys           
65                  70                  75                  80            

gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg        288
Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly           
                85                  90                  95                

ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc gga ggg        336
Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly           
            100                 105                 110                   

gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga        384
Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly           
        115                 120                 125                       

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc        432
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile           
    130                 135                 140                           

tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa        480
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu           
145                 150                 155                 160           

gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat        528
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His           
                165                 170                 175               

aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt        576
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg           
            180                 185                 190                   

gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag        624
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys           
        195                 200                 205                       

gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag        672
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu           
    210                 215                 220                           

aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac        720
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr           
225                 230                 235                 240           

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg        768
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu           
                245                 250                 255               

acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg        816
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp           
            260                 265                 270                   

gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg        864
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met           
        275                 280                 285                       

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac        912
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp           
    290                 295                 300                           

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat        960
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His           
305                 310                 315                 320           

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg       1008
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro           
                325                 330                 335               

ggt aaa                                                               1014
Gly Lys                                                                   
                                                                          


<210> 10
<211> 338
<212> PRT
<213> Homo sapiens

<400> 10
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly 
            100                 105                 110         


Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
        115                 120                 125             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    130                 135                 140                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
145                 150                 155                 160 


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                165                 170                 175     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
            180                 185                 190         


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
        195                 200                 205             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
    210                 215                 220                 


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
225                 230                 235                 240 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                245                 250                 255     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            260                 265                 270         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
        275                 280                 285             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210> 11
<211> 387
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(387)

<400> 11
atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt         48
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly           
1               5                   10                  15                

gtc cag tgt gag aca cgg tac tgc atc tac tac aac gcc aac tgg gag         96
Val Gln Cys Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu           
            20                  25                  30                    

ctg gag cgc acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag        144
Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln           
        35                  40                  45                        

gac aag cgg ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc        192
Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr           
    50                  55                  60                            

atc gag ctc gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac        240
Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr           
65                  70                  75                  80            

gat agg cag gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc        288
Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe           
                85                  90                  95                

tgc tgc tgt gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca        336
Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro           
            100                 105                 110                   

gag gct ggg ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc        384
Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro           
        115                 120                 125                       

acc                                                                    387
Thr                                                                       
                                                                          


<210> 12
<211> 129
<212> PRT
<213> Homo sapiens

<400> 12
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 
            20                  25                  30          


Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 
        35                  40                  45              


Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 
    50                  55                  60                  


Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 
65                  70                  75                  80  


Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 
                85                  90                  95      


Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 
            100                 105                 110         


Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 
        115                 120                 125             


Thr 
    


<210> 13
<211> 330
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(330)

<400> 13
gag aca cgg tac tgc atc tac tac aac gcc aac tgg gag ctg gag cgc         48
Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg           
1               5                   10                  15                

acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg         96
Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg           
            20                  25                  30                    

ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc        144
Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu           
        35                  40                  45                        

gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag        192
Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln           
    50                  55                  60                            

gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt        240
Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys           
65                  70                  75                  80            

gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg        288
Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly           
                85                  90                  95                

ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc                330
Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr                   
            100                 105                 110                   


<210> 14
<211> 110
<212> PRT
<213> Homo sapiens

<400> 14
Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210> 15
<211> 1071
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(1071)

<400> 15
atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt         48
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly           
1               5                   10                  15                

gtc cag tgt gag aca cgg tac tgc atc tac tac aac gcc aac tgg gag         96
Val Gln Cys Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu           
            20                  25                  30                    

ctg gag cgc acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag        144
Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln           
        35                  40                  45                        

gac aag cgg ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc        192
Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr           
    50                  55                  60                            

atc gag ctc gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac        240
Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr           
65                  70                  75                  80            

gat agg cag gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc        288
Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe           
                85                  90                  95                

tgc tgc tgt gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca        336
Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro           
            100                 105                 110                   

gag gct ggg ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc        384
Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro           
        115                 120                 125                       

acc gga ggg gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct        432
Thr Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro           
    130                 135                 140                           

gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc        480
Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr           
145                 150                 155                 160           

ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg        528
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val           
                165                 170                 175               

agc cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg        576
Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val           
            180                 185                 190                   

gag gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc aac agc        624
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser           
        195                 200                 205                       

acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg        672
Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu           
    210                 215                 220                           

aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc        720
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala           
225                 230                 235                 240           

ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca        768
Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro           
                245                 250                 255               

cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag        816
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln           
            260                 265                 270                   

gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc        864
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala           
        275                 280                 285                       

gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc aca        912
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr           
    290                 295                 300                           

cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc        960
Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu           
305                 310                 315                 320           

acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc       1008
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser           
                325                 330                 335               

gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc       1056
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser           
            340                 345                 350                   

ctg tct ccg ggt aaa                                                   1071
Leu Ser Pro Gly Lys                                                       
        355                                                               


<210> 16
<211> 357
<212> PRT
<213> Homo sapiens

<400> 16
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 
            20                  25                  30          


Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 
        35                  40                  45              


Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 
    50                  55                  60                  


Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 
65                  70                  75                  80  


Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 
                85                  90                  95      


Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 
            100                 105                 110         


Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
    130                 135                 140                 


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
        195                 200                 205             


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly Lys 
        355         


<210> 17
<211> 1014
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(1014)

<400> 17
gag aca cgg tac tgc atc tac tac aac gcc aac tgg gag ctg gag cgc         48
Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg           
1               5                   10                  15                

acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg         96
Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg           
            20                  25                  30                    

ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc        144
Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu           
        35                  40                  45                        

gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag        192
Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln           
    50                  55                  60                            

gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt        240
Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys           
65                  70                  75                  80            

gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg        288
Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly           
                85                  90                  95                

ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc gga ggg        336
Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly           
            100                 105                 110                   

gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga        384
Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly           
        115                 120                 125                       

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc        432
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile           
    130                 135                 140                           

tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa        480
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu           
145                 150                 155                 160           

gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat        528
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His           
                165                 170                 175               

aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt        576
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg           
            180                 185                 190                   

gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag        624
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys           
        195                 200                 205                       

gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag        672
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu           
    210                 215                 220                           

aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac        720
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr           
225                 230                 235                 240           

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg        768
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu           
                245                 250                 255               

acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg        816
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp           
            260                 265                 270                   

gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg        864
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met           
        275                 280                 285                       

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac        912
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp           
    290                 295                 300                           

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat        960
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His           
305                 310                 315                 320           

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg       1008
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro           
                325                 330                 335               

ggt aaa                                                               1014
Gly Lys                                                                   
                                                                          


<210> 18
<211> 338
<212> PRT
<213> Homo sapiens

<400> 18
Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly 
            100                 105                 110         


Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
        115                 120                 125             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    130                 135                 140                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
145                 150                 155                 160 


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                165                 170                 175     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
            180                 185                 190         


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
        195                 200                 205             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
    210                 215                 220                 


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
225                 230                 235                 240 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                245                 250                 255     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            260                 265                 270         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
        275                 280                 285             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210> 19
<211> 110
<212> PRT
<213> Homo sapiens

<400> 19
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210> 20
<211> 1014
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(1014)

<400> 20
gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag ctg gag cgc         48
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg           
1               5                   10                  15                

acc aac cag agc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg         96
Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg           
            20                  25                  30                    

ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc        144
Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu           
        35                  40                  45                        

gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag        192
Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln           
    50                  55                  60                            

gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt        240
Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys           
65                  70                  75                  80            

gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg        288
Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly           
                85                  90                  95                

ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc gga gga        336
Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly           
            100                 105                 110                   

gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga        384
Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly           
        115                 120                 125                       

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc        432
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile           
    130                 135                 140                           

tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa        480
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu           
145                 150                 155                 160           

gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat        528
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His           
                165                 170                 175               

aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt        576
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg           
            180                 185                 190                   

gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag        624
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys           
        195                 200                 205                       

gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag        672
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu           
    210                 215                 220                           

aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac        720
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr           
225                 230                 235                 240           

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg        768
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu           
                245                 250                 255               

acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg        816
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp           
            260                 265                 270                   

gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg        864
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met           
        275                 280                 285                       

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac        912
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp           
    290                 295                 300                           

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat        960
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His           
305                 310                 315                 320           

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg       1008
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro           
                325                 330                 335               

ggt aaa                                                               1014
Gly Lys                                                                   
                                                                          


<210> 21
<211> 338
<212> PRT
<213> Homo sapiens

<400> 21
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly 
            100                 105                 110         


Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
        115                 120                 125             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    130                 135                 140                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
145                 150                 155                 160 


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                165                 170                 175     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
            180                 185                 190         


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
        195                 200                 205             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
    210                 215                 220                 


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
225                 230                 235                 240 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                245                 250                 255     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            260                 265                 270         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
        275                 280                 285             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                325                 330                 335     


Gly Lys 
        


<210> 22
<211> 216
<212> PRT
<213> Homo sapiens

<400> 22
Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
            100                 105                 110         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        115                 120                 125             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    130                 135                 140                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
145                 150                 155                 160 


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                165                 170                 175     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            180                 185                 190         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        195                 200                 205             


Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215     


<210> 23
<211> 217
<212> PRT
<213> Homo sapiens

<400> 23
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Ile Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Gly Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210> 24
<211> 217
<212> PRT
<213> Homo sapiens

<400> 24
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215         


<210> 25
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Linker peptide

<400> 25
Gly Gly Gly Gly Ser 
1               5   


<210> 26
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker oligonucleotide


<220>
<221> CDS
<222> (1)..(36)

<400> 26
gga ggg gga gga tct gtc gag tgc cca ccg tgc cca                         36
Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro                           
1               5                   10                                    


<210> 27
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker peptide

<400> 27
Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210> 28
<211> 12
<212> PRT
<213> Homo sapiens

<400> 28
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210> 29
<211> 15
<212> PRT
<213> Homo sapiens

<400> 29
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210> 30
<211> 12
<212> PRT
<213> Homo sapiens

<400> 30
Glu Ser Lys Thr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210> 31
<211> 18
<212> PRT
<213> Homo sapiens

<400> 31
Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Trp 
1               5                   10                  15      


Pro Gly 
        


<210> 32
<211> 18
<212> PRT
<213> Homo sapiens

<400> 32
Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly 
        


<210> 33
<211> 512
<212> PRT
<213> Homo sapiens

<400> 33
Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          


Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              


Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  


Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  


Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      


Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         


Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             


Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu 
    130                 135                 140                 


Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 
145                 150                 155                 160 


Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 
                165                 170                 175     


Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 
            180                 185                 190         


Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 
        195                 200                 205             


Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 
    210                 215                 220                 


Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys 
225                 230                 235                 240 


His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 
                245                 250                 255     


Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser 
            260                 265                 270         


Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys 
        275                 280                 285             


His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 
    290                 295                 300                 


Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 
305                 310                 315                 320 


Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val 
                325                 330                 335     


Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 
            340                 345                 350         


Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu 
        355                 360                 365             


Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 
    370                 375                 380                 


Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 
385                 390                 395                 400 


Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 
                405                 410                 415     


Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 
            420                 425                 430         


His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro 
        435                 440                 445             


Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Glu Cys Trp Asp His Asp 
    450                 455                 460                 


Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 
465                 470                 475                 480 


Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu 
                485                 490                 495     


Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 
            500                 505                 510         


<210> 34
<211> 426
<212> PRT
<213> Homo sapiens

<400> 34
Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210> 35
<211> 375
<212> PRT
<213> Homo sapiens

<400> 35
Met Gln Lys Leu Gln Leu Cys Val Tyr Ile Tyr Leu Phe Met Leu Ile 
1               5                   10                  15      


Val Ala Gly Pro Val Asp Leu Asn Glu Asn Ser Glu Gln Lys Glu Asn 
            20                  25                  30          


Val Glu Lys Glu Gly Leu Cys Asn Ala Cys Thr Trp Arg Gln Asn Thr 
        35                  40                  45              


Lys Ser Ser Arg Ile Glu Ala Ile Lys Ile Gln Ile Leu Ser Lys Leu 
    50                  55                  60                  


Arg Leu Glu Thr Ala Pro Asn Ile Ser Lys Asp Val Ile Arg Gln Leu 
65                  70                  75                  80  


Leu Pro Lys Ala Pro Pro Leu Arg Glu Leu Ile Asp Gln Tyr Asp Val 
                85                  90                  95      


Gln Arg Asp Asp Ser Ser Asp Gly Ser Leu Glu Asp Asp Asp Tyr His 
            100                 105                 110         


Ala Thr Thr Glu Thr Ile Ile Thr Met Pro Thr Glu Ser Asp Phe Leu 
        115                 120                 125             


Met Gln Val Asp Gly Lys Pro Lys Cys Cys Phe Phe Lys Phe Ser Ser 
    130                 135                 140                 


Lys Ile Gln Tyr Asn Lys Val Val Lys Ala Gln Leu Trp Ile Tyr Leu 
145                 150                 155                 160 


Arg Pro Val Glu Thr Pro Thr Thr Val Phe Val Gln Ile Leu Arg Leu 
                165                 170                 175     


Ile Lys Pro Met Lys Asp Gly Thr Arg Tyr Thr Gly Ile Arg Ser Leu 
            180                 185                 190         


Lys Leu Asp Met Asn Pro Gly Thr Gly Ile Trp Gln Ser Ile Asp Val 
        195                 200                 205             


Lys Thr Val Leu Gln Asn Trp Leu Lys Gln Pro Glu Ser Asn Leu Gly 
    210                 215                 220                 


Ile Glu Ile Lys Ala Leu Asp Glu Asn Gly His Asp Leu Ala Val Thr 
225                 230                 235                 240 


Phe Pro Gly Pro Gly Glu Asp Gly Leu Asn Pro Phe Leu Glu Val Lys 
                245                 250                 255     


Val Thr Asp Thr Pro Lys Arg Ser Arg Arg Asp Phe Gly Leu Asp Cys 
            260                 265                 270         


Asp Glu His Ser Thr Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 
        275                 280                 285             


Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
    290                 295                 300                 


Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu Phe Val Phe Leu Gln Lys 
305                 310                 315                 320 


Tyr Pro His Thr His Leu Val His Gln Ala Asn Pro Arg Gly Ser Ala 
                325                 330                 335     


Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 
            340                 345                 350         


Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly Lys Ile Pro Ala Met Val 
        355                 360                 365             


Val Asp Arg Cys Gly Cys Ser 
    370                 375 


<210> 36
<211> 217
<212> PRT
<213> Homo sapiens

<400> 36
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Ile Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Gly Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210> 37
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker oligonucleotide


<220>
<221> CDS
<222> (1)..(48)

<400> 37
gga ggg gga gga tct gag cgc aaa tgt tgt gtc gag tgc cca ccg tgc         48
Gly Gly Gly Gly Ser Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys           
1               5                   10                  15                


<210> 38
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker peptide

<400> 38
Gly Gly Gly Gly Ser Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
1               5                   10                  15      


<210> 39
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker oligonucleotide


<220>
<221> CDS
<222> (1)..(42)

<400> 39
gga ggg gga gga tct ggt gga ggt ggt tca ggt cca ccg tgc                 42
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro Cys                   
1               5                   10                                    


<210> 40
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker peptide

<400> 40
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro Cys 
1               5                   10                  


<210> 41
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker oligonucleotide


<220>
<221> CDS
<222> (1)..(42)

<400> 41
gga ggg gga gga tct ggt gga ggt ggt tca ggt cca ccg gga                 42
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro Gly                   
1               5                   10                                    


<210> 42
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker peptide

<400> 42
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro Gly 
1               5                   10                  


<210> 43
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker oligonucleotide


<220>
<221> CDS
<222> (1)..(54)

<400> 43
gga ggg gga gga tct gag cgc aaa tgt cca cct tgt gtc gag tgc cca         48
Gly Gly Gly Gly Ser Glu Arg Lys Cys Pro Pro Cys Val Glu Cys Pro           
1               5                   10                  15                

ccg tgc                                                                 54
Pro Cys                                                                   
                                                                          


<210> 44
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker peptide

<400> 44
Gly Gly Gly Gly Ser Glu Arg Lys Cys Pro Pro Cys Val Glu Cys Pro 
1               5                   10                  15      


Pro Cys 
        


<210> 45
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker peptide

<400> 45
Gly Pro Ala Ser Gly Gly Pro Ala Ser Gly Pro Pro Cys Pro 
1               5                   10                  


<210> 46
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker peptide

<400> 46
Gly Pro Ala Ser Gly Gly Pro Ala Ser Gly Cys Pro Pro Cys Val Glu 
1               5                   10                  15      


Cys Pro Pro Cys Pro 
            20      


<210> 47
<211> 217
<212> PRT
<213> Homo sapiens

<400> 47
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210> 48
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker peptide

<400> 48
Gly Gly Gly Gly Ser Val Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210> 49
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker peptide

<400> 49
Gly Gly Gly Gly Ser Val Asp Lys Thr His Thr Gly Pro Pro Cys Pro 
1               5                   10                  15      


<210> 50
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Hinge linker peptide

<400> 50
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Asp Lys Thr His Thr 
1               5                   10                  15      


Gly Pro Pro Cys Pro 
            20      


<210> 51
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Gly Gly Gly Gly Gly 
1               5   


<210> 52
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210> 53
<211> 300
<212> DNA
<213> Homo sapiens

<400> 53
gagacacggt ggtgcatcta ctacaacgcc aactgggagc tggagcgcac caaccagacc       60

ggcctggagc gctgcgaagg cgagcaggac aagcggctgc actgctacgc ctcctggcgc      120

aacagctctg gcaccatcga gctcgtgaag aagggctgct ggctagatga cttcaactgc      180

tacgataggc aggagtgtgt ggccactgag gagaaccccc aggtgtactt ctgctgctgt      240

gagggcaact tctgcaacga gcgcttcact catttgccag aggctggggg cccggaagtc      300


