                         SEQUENCE LISTING

<110>  Sanofi
 
<120>  Exendin-4 Derivatives as Selective Glucagon Receptor Agonists

<130>  DE2014/055 

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  39
<212>  PRT
<213>  Heloderma suspectum


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  1

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  2
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  2

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  3
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is L-Norleucine (Nle)

<400>  3

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Xaa Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  4
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<400>  4

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  5
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<400>  5

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<400>  6

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  7
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<400>  7

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Val Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  8
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<400>  8

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Ile Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  9
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<400>  9

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Val Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  10
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is L-Phenylglycine (Phg)

<400>  10

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  11
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is L-1-Naphthylalanine (1NaI)

<400>  11

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  12
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<400>  12

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  13
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is L-Norleucine (Nle)

<400>  13

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Phe Ser Lys Gln Xaa Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  14
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is L-Norleucine (Nle)

<400>  14

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Ile Ser Lys Gln Xaa Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  15
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<400>  15

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  16
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is L-Norleucine (Nle)

<400>  16

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Xaa Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  17
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is L-Norleucine (Nle)

<400>  17

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Gln Xaa Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  18
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is L-2-Fluorophenylglycine (2FPhg)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is L-Norleucine (Nle)

<400>  18

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Gln Xaa Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  19
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is L-1-Naphthylalanine (1Nal)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is L-Norleucine (Nle)

<400>  19

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Gln Xaa Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  20
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is L-Cyclohexylglycine (Chg)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is L-Norleucine (Nle)

<400>  20

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Gln Xaa Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  21
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is L-2-Fluorophenylglycine (2FPhg)

<400>  21

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  22
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is L-1-Naphthylalanine (1Nal)

<400>  22

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  23
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is L-Cyclohexylglycine (Chg)

<400>  23

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  24
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is L-Cyclohexylglycine (Chg)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is L-Norleucine (Nle)

<400>  24

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Gln Xaa Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  25
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-4-Thiazolylalanine (Tza)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is L-tert-Leucine (Tle)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is L-Norleucine (Nle)

<400>  25

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Gln Xaa Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  26
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is L-Norleucine (Nle)

<400>  26

His Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Xaa Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  27
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide

<400>  27

His Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  28
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide

<400>  28

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Gly Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  29
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide

<400>  29

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  30
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide

<400>  30

His Ser Gln Gly Thr Phe Thr Ser Asp Val Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  31
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide

<400>  31

His Ser Gln Gly Thr Phe Thr Ser Asp Ile Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  32
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is L-Phenylglycine (Phg)

<400>  32

His Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  33
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is L-1-Naphthylalanine (1Nal)

<400>  33

His Ser Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  34
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide

<400>  34

His Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  35
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide

<400>  35

His Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  36
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is L-Norleucine (Nle)

<400>  36

His Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Xaa Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Glu Phe Ile Glu Trp Leu Leu Ala Thr Gly Pro Glu 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


