                         SEQUENCE LISTING

<110>  ProRec Bio AB
 
<120>  Prolactin receptor antagonists for treatment of glioblastoma

<130>  P3559PC00

<150>  SE 1450757-8
<151>  2014-06-18

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Lys Glu Asn Val Ala Ser Ala Thr Val Phe Thr Leu Leu Leu Phe 
1               5                   10                  15      


Leu Asn Thr Cys Leu Leu Asn Gly Gln Leu Pro Pro Gly Lys Pro Glu 
            20                  25                  30          


Ile Phe Lys Cys Arg Ser Pro Asn Lys Glu Thr Phe Thr Cys Trp Trp 
        35                  40                  45              


Arg Pro Gly Thr Asp Gly Gly Leu Pro Thr Asn Tyr Ser Leu Thr Tyr 
    50                  55                  60                  


His Arg Glu Gly Glu Thr Leu Met His Glu Cys Pro Asp Tyr Ile Thr 
65                  70                  75                  80  


Gly Gly Pro Asn Ser Cys His Phe Gly Lys Gln Tyr Thr Ser Met Trp 
                85                  90                  95      


Arg Thr Tyr Ile Met Met Val Asn Ala Thr Asn Gln Met Gly Ser Ser 
            100                 105                 110         


Phe Ser Asp Glu Leu Tyr Val Asp Val Thr Tyr Ile Val Gln Pro Asp 
        115                 120                 125             


Pro Pro Leu Glu Leu Ala Val Glu Val Lys Gln Pro Glu Asp Arg Lys 
    130                 135                 140                 


Pro Tyr Leu Trp Ile Lys Trp Ser Pro Pro Thr Leu Ile Asp Leu Lys 
145                 150                 155                 160 


Thr Gly Trp Phe Thr Leu Leu Tyr Glu Ile Arg Leu Lys Pro Glu Lys 
                165                 170                 175     


Ala Ala Glu Trp Glu Ile His Phe Ala Gly Gln Gln Thr Glu Phe Lys 
            180                 185                 190         


Ile Leu Ser Leu His Pro Gly Gln Lys Tyr Leu Val Gln Val Arg Cys 
        195                 200                 205             


Lys Pro Asp His Gly Tyr Trp Ser Ala Trp Ser Pro Ala Thr Phe Ile 
    210                 215                 220                 


Gln Ile Pro Ser Asp Phe Thr Met Asn Asp Thr Thr Val Trp Ile Ser 
225                 230                 235                 240 


Val Ala Val Leu Ser Ala Val Ile Cys Leu Ile Ile Val Trp Ala Val 
                245                 250                 255     


Ala Leu Lys Gly Tyr Ser Met Val Thr Cys Ile Phe Pro Pro Val Pro 
            260                 265                 270         


Gly Pro Lys Ile Lys Gly Phe Asp Ala His Leu Leu Glu Lys Gly Lys 
        275                 280                 285             


Ser Glu Glu Leu Leu Ser Ala Leu Gly Cys Gln Asp Phe Pro Pro Thr 
    290                 295                 300                 


Ser Asp Tyr Glu Asp Leu Leu Val Glu Tyr Leu Glu Val Asp Asp Ser 
305                 310                 315                 320 


Glu Asp Gln His Leu Met Ser Val His Ser Lys Glu His Pro Ser Gln 
                325                 330                 335     


Gly Met Lys Pro Thr Tyr Leu Asp Pro Asp Thr Asp Ser Gly Arg Gly 
            340                 345                 350         


Ser Cys Asp Ser Pro Ser Leu Leu Ser Glu Lys Cys Glu Glu Pro Gln 
        355                 360                 365             


Ala Asn Pro Ser Thr Phe Tyr Asp Pro Glu Val Ile Glu Lys Pro Glu 
    370                 375                 380                 


Asn Pro Glu Thr Thr His Thr Trp Asp Pro Gln Cys Ile Ser Met Glu 
385                 390                 395                 400 


Gly Lys Ile Pro Tyr Phe His Ala Gly Gly Ser Lys Cys Ser Thr Trp 
                405                 410                 415     


Pro Leu Pro Gln Pro Ser Gln His Asn Pro Arg Ser Ser Tyr His Asn 
            420                 425                 430         


Ile Thr Asp Val Cys Glu Leu Ala Val Gly Pro Ala Gly Ala Pro Ala 
        435                 440                 445             


Thr Leu Leu Asn Glu Ala Gly Lys Asp Ala Leu Lys Ser Ser Gln Thr 
    450                 455                 460                 


Ile Lys Ser Arg Glu Glu Gly Lys Ala Thr Gln Gln Arg Glu Val Glu 
465                 470                 475                 480 


Ser Phe His Ser Glu Thr Asp Gln Asp Thr Pro Trp Leu Leu Pro Gln 
                485                 490                 495     


Glu Lys Thr Pro Phe Gly Ser Ala Lys Pro Leu Asp Tyr Val Glu Ile 
            500                 505                 510         


His Lys Val Asn Lys Asp Gly Ala Leu Ser Leu Leu Pro Lys Gln Arg 
        515                 520                 525             


Glu Asn Ser Gly Lys Pro Lys Lys Pro Gly Thr Pro Glu Asn Asn Lys 
    530                 535                 540                 


Glu Tyr Ala Lys Val Ser Gly Val Met Asp Asn Asn Ile Leu Val Leu 
545                 550                 555                 560 


Val Pro Asp Pro His Ala Lys Asn Val Ala Cys Phe Glu Glu Ser Ala 
                565                 570                 575     


Lys Glu Ala Pro Pro Ser Leu Glu Gln Asn Gln Ala Glu Lys Ala Leu 
            580                 585                 590         


Ala Asn Phe Thr Ala Thr Ser Ser Lys Cys Arg Leu Gln Leu Gly Gly 
        595                 600                 605             


Leu Asp Tyr Leu Asp Pro Ala Cys Phe Thr His Ser Phe His 
    610                 615                 620         


<210>  2
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  2

Met Asn Ile Lys Gly Ser Pro Trp Lys Gly Ser Leu Leu Leu Leu Leu 
1               5                   10                  15      


Val Ser Asn Leu Leu Leu Cys Gln Ser Val Ala Pro Leu Pro Ile Cys 
            20                  25                  30          


Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp 
        35                  40                  45              


Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met 
    50                  55                  60                  


Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr 
65                  70                  75                  80  


Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp 
                85                  90                  95      


Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile 
            100                 105                 110         


Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr 
        115                 120                 125             


Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala 
    130                 135                 140                 


Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Gly Met Glu Leu 
145                 150                 155                 160 


Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro 
                165                 170                 175     


Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg 
            180                 185                 190         


Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His 
        195                 200                 205             


Lys Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys Arg Ile Ile His Asn 
    210                 215                 220                 


Asn Asn Cys 
225         


<210>  3
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  3

Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg 
1               5                   10                  15      


Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu 
            20                  25                  30          


Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg 
        35                  40                  45              


Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala 
    50                  55                  60                  


Thr Pro Glu Asp Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp Phe 
65                  70                  75                  80  


Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr 
                85                  90                  95      


His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile 
            100                 105                 110         


Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu 
        115                 120                 125             


Gly Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn 
    130                 135                 140                 


Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp 
145                 150                 155                 160 


Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg 
                165                 170                 175     


Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys Arg 
            180                 185                 190         


Ile Ile His Asn Asn Asn Cys 
        195                 


<210>  4
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  4

Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg 
1               5                   10                  15      


Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu 
            20                  25                  30          


Ala Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg 
        35                  40                  45              


Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala 
    50                  55                  60                  


Thr Pro Glu Asp Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe 
65                  70                  75                  80  


Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr 
                85                  90                  95      


His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile 
            100                 105                 110         


Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu 
        115                 120                 125             


Arg Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn 
    130                 135                 140                 


Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp 
145                 150                 155                 160 


Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg 
                165                 170                 175     


Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg 
            180                 185                 190         


Ile Ile His Asn Asn Asn Cys 
        195                 


<210>  5
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  5

Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp 
1               5                   10                  15      


Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ala 
            20                  25                  30          


Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly 
        35                  40                  45              


Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr 
    50                  55                  60                  


Pro Glu Asp Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu 
65                  70                  75                  80  


Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His 
                85                  90                  95      


Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu 
            100                 105                 110         


Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg 
        115                 120                 125             


Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu 
    130                 135                 140                 


Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu 
145                 150                 155                 160 


Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg 
                165                 170                 175     


Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile 
            180                 185                 190         


Ile His Asn Asn Asn Cys 
        195             


<210>  6
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  6

Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu 
1               5                   10                  15      


Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ala Ser 
            20                  25                  30          


Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe 
        35                  40                  45              


Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro 
    50                  55                  60                  


Glu Asp Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser 
65                  70                  75                  80  


Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu 
                85                  90                  95      


Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser 
            100                 105                 110         


Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met 
        115                 120                 125             


Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile 
    130                 135                 140                 


Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu 
145                 150                 155                 160 


Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp 
                165                 170                 175     


Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile 
            180                 185                 190         


His Asn Asn Asn Cys 
        195         


<210>  7
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  7

Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe 
1               5                   10                  15      


Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ala Ser Glu 
            20                  25                  30          


Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile 
        35                  40                  45              


Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu 
    50                  55                  60                  


Asp Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu 
65                  70                  75                  80  


Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val 
                85                  90                  95      


Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys 
            100                 105                 110         


Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu 
        115                 120                 125             


Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr 
    130                 135                 140                 


Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser 
145                 150                 155                 160 


Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser 
                165                 170                 175     


His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His 
            180                 185                 190         


Asn Asn Asn Cys 
        195     


<210>  8
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  8

Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp 
1               5                   10                  15      


Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ala Ser Glu Met 
            20                  25                  30          


Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr 
        35                  40                  45              


Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp 
    50                  55                  60                  


Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile 
65                  70                  75                  80  


Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr 
                85                  90                  95      


Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala 
            100                 105                 110         


Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu 
        115                 120                 125             


Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro 
    130                 135                 140                 


Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg 
145                 150                 155                 160 


Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His 
                165                 170                 175     


Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn 
            180                 185                 190         


Asn Asn Cys 
        195 


<210>  9
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  9

Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg 
1               5                   10                  15      


Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ala Ser Glu Met Phe 
            20                  25                  30          


Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys 
        35                  40                  45              


Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp Lys 
    50                  55                  60                  


Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val 
65                  70                  75                  80  


Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu 
                85                  90                  95      


Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val 
            100                 105                 110         


Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile 
        115                 120                 125             


Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val 
    130                 135                 140                 


Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu 
145                 150                 155                 160 


Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys 
                165                 170                 175     


Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn 
            180                 185                 190         


Asn Cys 
        


<210>  10
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  10

Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala 
1               5                   10                  15      


Val Val Leu Ser His Tyr Ile His Asn Leu Ala Ser Glu Met Phe Ser 
            20                  25                  30          


Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala 
        35                  40                  45              


Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp Lys Glu 
    50                  55                  60                  


Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser 
65                  70                  75                  80  


Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val 
                85                  90                  95      


Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu 
            100                 105                 110         


Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val 
        115                 120                 125             


Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp 
    130                 135                 140                 


Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser 
145                 150                 155                 160 


Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile 
                165                 170                 175     


Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn 
            180                 185                 190         


Cys 
    


<210>  11
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  11

Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val 
1               5                   10                  15      


Val Leu Ser His Tyr Ile His Asn Leu Ala Ser Glu Met Phe Ser Glu 
            20                  25                  30          


Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile 
        35                  40                  45              


Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp Lys Glu Gln 
    50                  55                  60                  


Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile 
65                  70                  75                  80  


Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg 
                85                  90                  95      


Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile 
            100                 105                 110         


Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser 
        115                 120                 125             


Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser 
    130                 135                 140                 


Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala 
145                 150                 155                 160 


Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp 
                165                 170                 175     


Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190         


<210>  12
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  12

Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val 
1               5                   10                  15      


Leu Ser His Tyr Ile His Asn Leu Ala Ser Glu Met Phe Ser Glu Phe 
            20                  25                  30          


Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn 
        35                  40                  45              


Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp Lys Glu Gln Ala 
    50                  55                  60                  


Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu 
65                  70                  75                  80  


Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly 
                85                  90                  95      


Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu 
            100                 105                 110         


Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln 
        115                 120                 125             


Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly 
    130                 135                 140                 


Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr 
145                 150                 155                 160 


Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn 
                165                 170                 175     


Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190     


<210>  13
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  13

Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val Leu 
1               5                   10                  15      


Ser His Tyr Ile His Asn Leu Ala Ser Glu Met Phe Ser Glu Phe Asp 
            20                  25                  30          


Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser 
        35                  40                  45              


Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp Lys Glu Gln Ala Leu 
    50                  55                  60                  


Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu Arg 
65                  70                  75                  80  


Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met 
                85                  90                  95      


Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu Glu 
            100                 105                 110         


Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln Val 
        115                 120                 125             


His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly Leu 
    130                 135                 140                 


Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr Tyr 
145                 150                 155                 160 


Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn Tyr 
                165                 170                 175     


Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190 


<210>  14
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  14

Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val Leu Ser 
1               5                   10                  15      


His Tyr Ile His Asn Leu Ala Ser Glu Met Phe Ser Glu Phe Asp Lys 
            20                  25                  30          


Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys 
        35                  40                  45              


His Thr Ser Ser Leu Ala Thr Pro Glu Asp Lys Glu Gln Ala Leu Gln 
    50                  55                  60                  


Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser 
65                  70                  75                  80  


Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met Gln 
                85                  90                  95      


Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu Glu Gln 
            100                 105                 110         


Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln Val His 
        115                 120                 125             


Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro 
    130                 135                 140                 


Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn 
145                 150                 155                 160 


Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn Tyr Leu 
                165                 170                 175     


Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 


<210>  15
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  15

Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val Leu Ser His 
1               5                   10                  15      


Tyr Ile His Asn Leu Ala Ser Glu Met Phe Ser Glu Phe Asp Lys Arg 
            20                  25                  30          


Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His 
        35                  40                  45              


Thr Ser Ser Leu Ala Thr Pro Glu Asp Lys Glu Gln Ala Leu Gln Met 
    50                  55                  60                  


Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp 
65                  70                  75                  80  


Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met Gln Glu 
                85                  90                  95      


Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr 
            100                 105                 110         


Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln Val His Pro 
        115                 120                 125             


Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser 
    130                 135                 140                 


Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu 
145                 150                 155                 160 


Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys 
                165                 170                 175     


Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185             


<210>  16
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  16

Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr 
1               5                   10                  15      


Ile His Asn Leu Ala Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr 
            20                  25                  30          


Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr 
        35                  40                  45              


Ser Ser Leu Ala Thr Pro Glu Asp Lys Glu Gln Ala Leu Gln Met Asn 
    50                  55                  60                  


Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn 
65                  70                  75                  80  


Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala 
                85                  90                  95      


Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys 
            100                 105                 110         


Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln Val His Pro Glu 
        115                 120                 125             


Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu 
    130                 135                 140                 


Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu 
145                 150                 155                 160 


His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu 
                165                 170                 175     


Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185         


<210>  17
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  17

Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg 
1               5                   10                  15      


Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu 
            20                  25                  30          


Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg 
        35                  40                  45              


Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ala Ser Leu Ala 
    50                  55                  60                  


Thr Pro Glu Asn Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe 
65                  70                  75                  80  


Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr 
                85                  90                  95      


His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile 
            100                 105                 110         


Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu 
        115                 120                 125             


Arg Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn 
    130                 135                 140                 


Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp 
145                 150                 155                 160 


Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg 
                165                 170                 175     


Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg 
            180                 185                 190         


Ile Ile His Asn Asn Asn Cys 
        195                 


<210>  18
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  18

Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp 
1               5                   10                  15      


Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser 
            20                  25                  30          


Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly 
        35                  40                  45              


Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ala Ser Leu Ala Thr 
    50                  55                  60                  


Pro Glu Asn Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu 
65                  70                  75                  80  


Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His 
                85                  90                  95      


Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu 
            100                 105                 110         


Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg 
        115                 120                 125             


Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu 
    130                 135                 140                 


Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu 
145                 150                 155                 160 


Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg 
                165                 170                 175     


Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile 
            180                 185                 190         


Ile His Asn Asn Asn Cys 
        195             


<210>  19
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  19

Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu 
1               5                   10                  15      


Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser 
            20                  25                  30          


Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe 
        35                  40                  45              


Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ala Ser Leu Ala Thr Pro 
    50                  55                  60                  


Glu Asn Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser 
65                  70                  75                  80  


Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu 
                85                  90                  95      


Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser 
            100                 105                 110         


Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met 
        115                 120                 125             


Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile 
    130                 135                 140                 


Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu 
145                 150                 155                 160 


Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp 
                165                 170                 175     


Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile 
            180                 185                 190         


His Asn Asn Asn Cys 
        195         


<210>  20
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  20

Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe 
1               5                   10                  15      


Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu 
            20                  25                  30          


Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile 
        35                  40                  45              


Thr Lys Ala Ile Asn Ser Cys His Thr Ala Ser Leu Ala Thr Pro Glu 
    50                  55                  60                  


Asn Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu 
65                  70                  75                  80  


Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val 
                85                  90                  95      


Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys 
            100                 105                 110         


Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu 
        115                 120                 125             


Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr 
    130                 135                 140                 


Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser 
145                 150                 155                 160 


Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser 
                165                 170                 175     


His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His 
            180                 185                 190         


Asn Asn Asn Cys 
        195     


<210>  21
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  21

Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp 
1               5                   10                  15      


Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met 
            20                  25                  30          


Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr 
        35                  40                  45              


Lys Ala Ile Asn Ser Cys His Thr Ala Ser Leu Ala Thr Pro Glu Asn 
    50                  55                  60                  


Lys Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile 
65                  70                  75                  80  


Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr 
                85                  90                  95      


Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala 
            100                 105                 110         


Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu 
        115                 120                 125             


Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro 
    130                 135                 140                 


Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg 
145                 150                 155                 160 


Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His 
                165                 170                 175     


Lys Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn 
            180                 185                 190         


Asn Asn Cys 
        195 


<210>  22
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  22

Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg 
1               5                   10                  15      


Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met Phe 
            20                  25                  30          


Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys 
        35                  40                  45              


Ala Ile Asn Ser Cys His Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys 
    50                  55                  60                  


Glu Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val 
65                  70                  75                  80  


Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu 
                85                  90                  95      


Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val 
            100                 105                 110         


Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile 
        115                 120                 125             


Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val 
    130                 135                 140                 


Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu 
145                 150                 155                 160 


Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys 
                165                 170                 175     


Ile Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn 
            180                 185                 190         


Asn Cys 
        


<210>  23
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  23

Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala 
1               5                   10                  15      


Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met Phe Ser 
            20                  25                  30          


Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala 
        35                  40                  45              


Ile Asn Ser Cys His Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys Glu 
    50                  55                  60                  


Gln Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser 
65                  70                  75                  80  


Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val 
                85                  90                  95      


Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu 
            100                 105                 110         


Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val 
        115                 120                 125             


Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp 
    130                 135                 140                 


Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser 
145                 150                 155                 160 


Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile 
                165                 170                 175     


Asp Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn 
            180                 185                 190         


Cys 
    


<210>  24
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  24

Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val 
1               5                   10                  15      


Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met Phe Ser Glu 
            20                  25                  30          


Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile 
        35                  40                  45              


Asn Ser Cys His Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys Glu Gln 
    50                  55                  60                  


Ala Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile 
65                  70                  75                  80  


Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg 
                85                  90                  95      


Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile 
            100                 105                 110         


Glu Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser 
        115                 120                 125             


Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser 
    130                 135                 140                 


Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala 
145                 150                 155                 160 


Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp 
                165                 170                 175     


Asn Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190         


<210>  25
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  25

Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val 
1               5                   10                  15      


Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met Phe Ser Glu Phe 
            20                  25                  30          


Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn 
        35                  40                  45              


Ser Cys His Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys Glu Gln Ala 
    50                  55                  60                  


Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu 
65                  70                  75                  80  


Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly 
                85                  90                  95      


Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu 
            100                 105                 110         


Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln 
        115                 120                 125             


Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly 
    130                 135                 140                 


Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr 
145                 150                 155                 160 


Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn 
                165                 170                 175     


Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190     


<210>  26
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  26

Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val Leu 
1               5                   10                  15      


Ser His Tyr Ile His Asn Leu Ser Ser Glu Met Phe Ser Glu Phe Asp 
            20                  25                  30          


Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser 
        35                  40                  45              


Cys His Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys Glu Gln Ala Leu 
    50                  55                  60                  


Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu Arg 
65                  70                  75                  80  


Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met 
                85                  90                  95      


Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu Glu 
            100                 105                 110         


Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln Val 
        115                 120                 125             


His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly Leu 
    130                 135                 140                 


Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr Tyr 
145                 150                 155                 160 


Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn Tyr 
                165                 170                 175     


Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190 


<210>  27
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  27

Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val Leu Ser 
1               5                   10                  15      


His Tyr Ile His Asn Leu Ser Ser Glu Met Phe Ser Glu Phe Asp Lys 
            20                  25                  30          


Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys 
        35                  40                  45              


His Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys Glu Gln Ala Leu Gln 
    50                  55                  60                  


Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser 
65                  70                  75                  80  


Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met Gln 
                85                  90                  95      


Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu Glu Gln 
            100                 105                 110         


Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln Val His 
        115                 120                 125             


Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro 
    130                 135                 140                 


Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn 
145                 150                 155                 160 


Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn Tyr Leu 
                165                 170                 175     


Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 


<210>  28
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  28

Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val Leu Ser His 
1               5                   10                  15      


Tyr Ile His Asn Leu Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg 
            20                  25                  30          


Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His 
        35                  40                  45              


Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys Glu Gln Ala Leu Gln Met 
    50                  55                  60                  


Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp 
65                  70                  75                  80  


Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met Gln Glu 
                85                  90                  95      


Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr 
            100                 105                 110         


Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln Val His Pro 
        115                 120                 125             


Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser 
    130                 135                 140                 


Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu 
145                 150                 155                 160 


Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys 
                165                 170                 175     


Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185             


<210>  29
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  29

Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr 
1               5                   10                  15      


Ile His Asn Leu Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr 
            20                  25                  30          


Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr 
        35                  40                  45              


Ala Ser Leu Ala Thr Pro Glu Asn Lys Glu Gln Ala Leu Gln Met Asn 
    50                  55                  60                  


Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn 
65                  70                  75                  80  


Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala 
                85                  90                  95      


Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys 
            100                 105                 110         


Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln Val His Pro Glu 
        115                 120                 125             


Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu 
    130                 135                 140                 


Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu 
145                 150                 155                 160 


His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu 
                165                 170                 175     


Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185         


<210>  30
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  30

Ser Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val Leu Ser His 
1               5                   10                  15      


Tyr Ile His Asn Leu Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg 
            20                  25                  30          


Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His 
        35                  40                  45              


Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys Glu Gln Ala Leu Gln Met 
    50                  55                  60                  


Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp 
65                  70                  75                  80  


Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met Gln Glu 
                85                  90                  95      


Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr 
            100                 105                 110         


Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln Val His Pro 
        115                 120                 125             


Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser 
    130                 135                 140                 


Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu 
145                 150                 155                 160 


Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys 
                165                 170                 175     


Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185             


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal tag

<400>  31

Cys Pro Gly Pro Pro Gly Ser 
1               5           


<210>  32
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal tag

<400>  32

Asp Asp Glu Trp Leu Cys Gly Trp Arg Pro Leu Cys Ile Asp Glu Ile 
1               5                   10                  15      


Leu Arg Pro Gly Pro Pro Gly Ser 
            20                  


<210>  33
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  33

Ser Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val 
1               5                   10                  15      


Leu Ser His Tyr Ile His Asn Leu Ala Ser Glu Met Phe Ser Glu Phe 
            20                  25                  30          


Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn 
        35                  40                  45              


Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp Lys Glu Gln Ala 
    50                  55                  60                  


Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu 
65                  70                  75                  80  


Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly 
                85                  90                  95      


Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu 
            100                 105                 110         


Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln 
        115                 120                 125             


Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly 
    130                 135                 140                 


Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr 
145                 150                 155                 160 


Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn 
                165                 170                 175     


Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190     


<210>  34
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  34

Ser Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp Arg Ala Val Val 
1               5                   10                  15      


Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met Phe Ser Glu Phe 
            20                  25                  30          


Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr Lys Ala Ile Asn 
        35                  40                  45              


Ser Cys His Thr Ala Ser Leu Ala Thr Pro Glu Asn Lys Glu Gln Ala 
    50                  55                  60                  


Leu Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile Val Ser Ile Leu 
65                  70                  75                  80  


Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly 
                85                  90                  95      


Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala Val Glu Ile Glu 
            100                 105                 110         


Glu Gln Thr Lys Arg Leu Leu Glu Arg Met Glu Leu Ile Val Ser Gln 
        115                 120                 125             


Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro Val Trp Ser Gly 
    130                 135                 140                 


Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg Leu Ser Ala Tyr 
145                 150                 155                 160 


Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His Lys Ile Asp Asn 
                165                 170                 175     


Tyr Leu Lys Leu Leu Arg Cys Arg Ile Ile His Asn Asn Asn Cys 
            180                 185                 190     


