                         SEQUENCE LISTING

<110>  Ablynx N.V.
       Ablynx N.V.
 
<120>  KV1.3 BINDING IMMUNOGLOBULINS

<130>  P14-001-PCT-1

<150>  US 62/133,624
<151>  2015-03-16

<150>  US 62/014,023
<151>  2014-06-18

<150>  NL 2013661
<151>  2014-10-21

<160>  559   

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Thr Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  2
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Thr Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  3
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody sequence

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  4
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Thr Asn Thr Val His Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Ser Trp Arg Thr Gly Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  5
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Thr Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Glu Ala Tyr Glu Tyr Trp Gly Arg Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  6
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Thr Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Ala Tyr Glu His Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  7
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Thr Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Val Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Glu Ala Tyr Glu Tyr Trp Gly Arg Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  8
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Ser Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Thr Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Ala Tyr Glu Tyr Trp Gly Gln Gly Ala Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  9
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Thr Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  10
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Thr Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Glu Ala Tyr Glu Tyr Trp Gly Arg Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  11
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Glu Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Lys Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ala Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  12
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Ala Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  13
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  14
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  15
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Leu Arg Thr Thr Gly Ser Thr Asn Tyr Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ala Trp Arg Ile Glu Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  16
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  17
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Lys Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  18
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  19
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  19

Glu Val Gln Leu Val Glu Ser Ala Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Pro Gly Leu Ser Ser Ser Asp Ser Gly Leu Leu Phe Ser Arg His 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Pro Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  20
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Leu Met Asn Asp Leu Asn Arg Glu Tyr Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Phe Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  21
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ala Leu Gly Leu Pro Cys Ser Ala Ser Gly Leu Leu Phe Ile Arg Asn 
            20                  25                  30          


Ser Ala Ser Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Ile Asp Leu Lys Pro Glu Asp Thr Thr Val Tyr Cys Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  22
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Val Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  23
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Arg Tyr Arg Gln Ala Pro Gly Lys Arg Pro Glu Phe Phe 
        35                  40                  45              


Ala Arg Val Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Ser Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  24
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly His Ser Cys Ser Ala Ser Gly Leu Leu Ser Ser Cys Asn 
            20                  25                  30          


Thr Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Val Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  25
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Ala Ser Arg Ser Ala Ser Gly Leu Pro Leu Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Gly Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Gly Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Gly Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  26
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Pro Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Cys Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Thr Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Val Cys Leu Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Arg Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  27
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Cys Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Leu Leu Phe Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Arg Trp Tyr Arg Gln Ala Pro Val Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Gly Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Gly Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  28
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ala Cys Ser Ala Ser Gly Leu Leu Ile Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg His Ala Pro Gly Lys Gln Arg Ala Phe Val 
        35                  40                  45              


Ala Arg Val Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ala Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ala Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Ile Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  29
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Lys Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Val Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Pro 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Ala Ala Lys Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Lys Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  30
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Ala Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Lys Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  31
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ala Leu Gly Phe Thr Cys Ser Asp Ser Arg Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Ala Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Arg Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Ile Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  32
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Pro Cys Ser Ala Pro Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Val Arg Met Gly Gly Ser Ile Asn Tyr Gly Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Gly Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  33
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Asp Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Pro Cys Ser Ala Pro Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Arg Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  34
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Cys Pro Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Cys Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Val Asp Asp Leu Lys Pro Glu Asp Thr Ala Ile Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  35
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Glu Thr Ala Trp Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Ser Gln Arg Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  36
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  36

Glu Val Gln Leu Val Glu Ser Ala Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asp Thr Arg Tyr Met 
65                  70                  75                  80  


Gln Ile Asn Asp Leu Lys Pro Glu Asp Thr Ala Lys Tyr Phe Cys Arg 
                85                  90                  95      


Ser Trp Arg Glu Gly Leu Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  37
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Leu Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Leu Ser Arg Asn 
            20                  25                  30          


Arg Ala Arg Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Met Asn Asp Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Ile Tyr Phe Cys Arg 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  38
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp His Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Glu Leu Lys Pro Glu Asp Thr Ala Lys Tyr Leu Cys Arg 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Ser Trp Gly Arg Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  39
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Pro Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ala Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Glu Thr Ala Ile Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Val Tyr Lys Tyr Gly Gly Lys Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  40
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Arg Arg Gly Leu Ser Cys Ser Ala Ser Gly Phe Leu Phe Arg Arg Pro 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Asp Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Val Lys Pro Glu Asp Thr Ala Lys Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  41
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ile Arg Asn 
            20                  25                  30          


Ser Ala Gly Cys Tyr Arg Gln Ala Pro Gly Lys His Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Tyr Thr Ala Ile Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Tyr Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  42
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Ile 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Glu Ala Pro Gly Gln Gln Arg Glu Cys Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu His Thr Ala Lys Tyr Leu Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  43
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Glu Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Pro Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Lys Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Arg Gly Gly Gly Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Ile Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Asp Glu Tyr Trp Ala Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  44
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Pro Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Leu Ala Phe Val 
        35                  40                  45              


Gly Arg Ile Gly Met Gly Gly Cys Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Lys Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  45
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Ala Gly 
1               5                   10                  15      


Ser Leu Gly Leu Pro Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Met 
            20                  25                  30          


Ser Ala Arg Trp Tyr Arg Gln Ala Pro Gly Glu Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Thr Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Lys Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Cys Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  46
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Glu Gly Leu Val Pro Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Pro Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Tyr 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ser Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Glu Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Ile Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  47
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Pro Pro Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Asp Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Asp Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asn Thr Ala Lys Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Lys Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  48
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Gln Lys Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Gly Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  49
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ile Ala Gly Trp Tyr Arg Pro Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Asn Gly Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asp Asp Leu Lys Pro Glu Asp Thr Ala Ile Cys Phe Cys Ser 
                85                  90                  95      


Ser Gly Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  50
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  50

Glu Val Gln Leu Val Glu Ser Ala Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Pro Leu Gly Leu Ser Cys Ser Ser Ser Gly Leu Leu Phe Ser Leu Asn 
            20                  25                  30          


Ser Ala Gly Cys Ser Arg Gln Pro Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Lys Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  51
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Pro Pro Cys Pro Ala Ser Gly Pro Leu Phe Arg Arg Thr 
            20                  25                  30          


Arg Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Lys Tyr Phe Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  52
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Cys Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Pro Gly Leu Leu Phe Ser Pro Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Leu Met Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Lys Asp Leu Lys Pro Glu Asp Thr Ala Lys Tyr Phe Cys Ser 
                85                  90                  95      


Arg Trp Arg Glu Gly Phe Tyr Glu Tyr Cys Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  53
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Pro Leu Gly Leu Ser Cys Ser Ala Ser Gly Ile Pro Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Arg Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Gly Asp Ile Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Lys Asp Phe Gly Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  54
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Arg Gly Gly Asp Thr Asn Tyr Ala Glu Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Lys Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Trp Arg Thr Gly Ser Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  55
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Ile Phe Val 
        35                  40                  45              


Ala Arg Leu Arg Arg Gly Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ala Trp Arg Ala Gly Thr Tyr Glu Tyr Trp Gly Gln Val Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  56
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Ile Phe Val 
        35                  40                  45              


Ala Arg Leu Arg Arg Gly Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ala Trp Arg Ala Gly Thr Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  57
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Leu Arg Thr Thr Gly Ser Thr Asn Tyr Ala Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ala Trp Arg Ile Glu Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  58
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Ser Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Leu Tyr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Ala Tyr Glu Tyr Trp Gly Gln Trp Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  59
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Arg Val Asn 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Arg Gly Gly Ser Thr Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Ser Pro Ala Asp Thr Gly Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  60
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Leu Arg Arg Gly Gly Glu Thr Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Thr Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Ser Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  61
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Arg Val Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Gln Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Ser Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Ile Asp Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  62
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  62

Glu Val Gln Leu Val Glu Ser Ala Gly Gly Leu Val Pro Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Pro Cys Ser Ala Pro Gly Leu Leu Phe Ser Val Asp 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Asp Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  63
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Thr Val Ser Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Cys Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys His Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  64
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Glu Gly Leu Val Lys Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asp 
            20                  25                  30          


Ser Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Phe 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Thr Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Ile Gly Ser Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  65
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Arg Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly His Lys Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Ser Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  66
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Arg Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Ser Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly His Lys Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Ser Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  67
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Ala Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Arg Gly Glu Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Ala Arg His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  68
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Ala Gly Arg Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala Lys Asn Ile Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  69
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Ala Ser Arg Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala Lys Asn Ile Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  70
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly His Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Arg Ala Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  71
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Val Ser Gly Gly Asn Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala His Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  72
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Ala Gly Arg Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala Lys Asn Val Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  73
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ser Ser Ser Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Leu Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Asp Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  74
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala Lys Asn Ile Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  75
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Asp Gln Gly Gln Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Arg Thr Tyr Phe Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ile Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  76
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Arg Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Ala Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Thr 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  77
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Asn Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Val Gln Gly Thr Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Arg Thr Tyr Phe Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Asn 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  78
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  78

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Arg Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly His Lys Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Ser Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  79
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Ala Gly Arg Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala Lys Asn Ile Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  80
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Gly Tyr Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  81
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ile Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  82
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Arg Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  83
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Ala Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Arg Gly Glu Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Ala Arg His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Asp Gly Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  84
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  84

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Ala Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Lys Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  85
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Val Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly His Ile Phe Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ile Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  86
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  86

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Ala Gly Arg Thr Tyr Tyr Ser Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala Lys Asn Ile Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  87
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Asn Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Tyr Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  88
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  88

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Arg Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Arg Lys Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Ser Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  89
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Ala Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Arg Gly Glu Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Ala Arg His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  90
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Ala Gly Thr Leu Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Arg Gly Glu Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Ala Arg His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Arg 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  91
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Ala Gly Thr Leu Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Arg Gly Glu Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Ala Arg His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  92
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  92

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala Lys Asn Ile Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  93
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Ala Gly Thr Leu Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Arg Gly Glu Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Ala Arg His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  94
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  94

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ser Ser Lys Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Leu Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Asn Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Asp Asp Asp Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  95
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Pro Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Ala Gly Arg Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala Lys Asn Ile Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  96
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  96

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Asp Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Asn Gly His Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ile Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Thr 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  97
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Gly His Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Ser Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  98
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  98

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ile Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Asn 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  99
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Pro Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Ala Gly Arg Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala Lys Asn Ile Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  100
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  100

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Val Cys Ala Phe Ser Gly Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Tyr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Arg Phe Arg Phe Gly Asp Gly Ala Tyr Tyr Tyr Gln Arg Thr 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  101
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Arg Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Gly His Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Ser Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  102
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  102

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Arg Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Gly His Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Lys Asp Asn Ala Lys Asn Met Met Ser 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Phe Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  103
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  103

Lys Val Gln Leu Val Glu Ser Arg Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Arg Thr Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  104
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  104

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala Lys Asn Ile Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  105
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Asn Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Thr Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Arg Thr Tyr Phe Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Asn 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Ala Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  106
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ala 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asn Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  107
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Asn 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  108
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  108

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Val Gly Asn Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  109
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Val Ser Gly Gly Asn Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala His Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  110
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  110

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly His Thr Tyr Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ile Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  111
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  111

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Gly His Ile Phe Tyr Ser Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ile 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  112
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Ala Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Arg Gly Glu Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Ala Arg His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  113
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  113

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Arg Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ile Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  114
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Val Ser Gly Gly Asn Phe Arg Asn Phe 
            20                  25                  30          


Gly Val Gly Trp Phe Arg Gln Ala His Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ala Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Thr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Gly Asp Gly Thr Ser Tyr Tyr Glu Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  115
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  115

Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Ala Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Thr Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Arg Thr Tyr Phe Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Met Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Ala Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  116
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Val Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Phe Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly His Ile Phe Tyr Ser Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  117
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Ala Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Arg Gly Glu Ala Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Gly His Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  118
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  118

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ser Ser Ser Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Gly His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Leu Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Asp Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  119
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  119

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Asn 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Gly Gly His Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  120
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Arg Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly His Lys Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Lys Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Ser Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  121
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  121

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Asn Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Val Gln Gly Thr Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly Arg Thr Tyr Phe Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Asn 
            100                 105                 110         


Phe Tyr Gly Phe Trp Gly Gln Gly Ala Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  122
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  122

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Ala Gly His Ile Tyr Tyr Leu Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ile Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  123
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asn 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Ala Gly Thr Leu Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Arg Gly Glu Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Ser Ala Arg His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  124
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  125
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  125

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  126
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Glu Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  127
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  127

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  128
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  128

Glu Val Gln Leu Val Glu Ser Ala Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Pro Gly Leu Ser Ser Ser Asp Ser 
            20                  25  


<210>  129
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ala Leu Gly Leu Pro Cys Ser Ala Ser 
            20                  25  


<210>  130
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  130

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  131
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  131

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly His Ser Cys Ser Ala Ser 
            20                  25  


<210>  132
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Ala Ser Arg Ser Ala Ser 
            20                  25  


<210>  133
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Pro 
            20                  25  


<210>  134
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  134

Glu Val Gln Leu Val Glu Ser Gly Gly Cys Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  135
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  135

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ala Cys Ser Ala Ser 
            20                  25  


<210>  136
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  137
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  137

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Ala Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  138
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  138

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ala Leu Gly Phe Thr Cys Ser Asp Ser 
            20                  25  


<210>  139
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Pro Cys Ser Ala Pro 
            20                  25  


<210>  140
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  140

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Asp Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Pro Cys Ser Ala Pro 
            20                  25  


<210>  141
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  141

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Cys Pro Ala Ser 
            20                  25  


<210>  142
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  142

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  143
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  143

Glu Val Gln Leu Val Glu Ser Ala Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  144
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  144

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Leu Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  145
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  145

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Arg Arg Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  146
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  146

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  147
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  147

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  148
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Glu Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  149
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  149

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Pro Leu Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  150
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  150

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Ala Gly 
1               5                   10                  15      


Ser Leu Gly Leu Pro Cys Ser Ala Ser 
            20                  25  


<210>  151
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  151

Glu Val Gln Leu Val Glu Ser Gly Glu Gly Leu Val Pro Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Pro Ser Cys Ser Ala Ser 
            20                  25  


<210>  152
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Pro Pro Gly Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  153
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  153

Glu Val Gln Leu Val Glu Ser Ala Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Pro Leu Gly Leu Ser Cys Ser Ser Ser 
            20                  25  


<210>  154
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  154

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Pro Pro Cys Pro Ala Ser 
            20                  25  


<210>  155
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  155

Glu Val Gln Leu Val Glu Ser Gly Gly Cys Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Pro 
            20                  25  


<210>  156
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  156

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  157
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  157

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  158
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  158

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  159
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  160
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  160

Glu Val Gln Leu Val Glu Ser Ala Gly Gly Leu Val Pro Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Pro Cys Ser Ala Pro 
            20                  25  


<210>  161
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  162
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Glu Gly Leu Val Lys Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  163
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  163

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  164
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  164

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  165
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  165

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Val Ser 
            20                  25  


<210>  166
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  166

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ser Ser 
            20                  25  


<210>  167
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  167

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  168
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  168

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  169
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  169

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  170
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  170

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  171
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  171

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ser Ser 
            20                  25  


<210>  172
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Pro Cys Thr Ala Ser 
            20                  25  


<210>  173
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  173

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  174
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  174

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Pro Leu Ser Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  175
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  175

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Val Cys Ala Phe Ser 
            20                  25  


<210>  176
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  176

Lys Val Gln Leu Val Glu Ser Arg Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  177
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  178
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  178

Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  179
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Asn 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  180
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asn 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  181

Gly Leu Leu Phe Ser Val Asn Ser Ala Gly 
1               5                   10  


<210>  182
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  182

Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly 
1               5                   10  


<210>  183
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  183

Gly Leu Leu Phe Ser Arg Asn Ser Val Gly 
1               5                   10  


<210>  184
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  184

Gly Leu Leu Phe Ser Ala Asn Ser Ala Gly 
1               5                   10  


<210>  185
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  185

Gly Leu Leu Phe Ser Val Asn Ser Val Gly 
1               5                   10  


<210>  186
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  186

Gly Leu Leu Phe Ser Arg His Ser Ala Gly 
1               5                   10  


<210>  187
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  187

Gly Leu Leu Phe Ile Arg Asn Ser Ala Ser 
1               5                   10  


<210>  188
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  188

Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Arg 
1               5                   10      


<210>  189
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  189

Gly Leu Leu Ser Ser Cys Asn Thr Ala Gly 
1               5                   10  


<210>  190
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  190

Gly Leu Pro Leu Ser Arg Asn Ser Ala Gly 
1               5                   10  


<210>  191
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  191

Leu Leu Phe Phe Ser Arg Asn Ser Ala Arg 
1               5                   10  


<210>  192
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  192

Gly Leu Leu Ile Ser Arg Asn Ser Ala Gly 
1               5                   10  


<210>  193
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  193

Arg Leu Leu Phe Ser Arg Asn Ser Ala Gly 
1               5                   10  


<210>  194
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  194

Gly Leu Leu Phe Ser Arg Asn Arg Val Gly 
1               5                   10  


<210>  195
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  195

Gly Leu Leu Leu Ser Arg Asn Arg Ala Arg 
1               5                   10  


<210>  196
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  196

Gly Phe Leu Phe Arg Arg Pro Ser Ala Gly 
1               5                   10  


<210>  197
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  197

Gly Leu Leu Phe Ile Arg Asn Ser Ala Gly Cys 
1               5                   10      


<210>  198
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  198

Gly Leu Leu Phe Ser Arg Ile Ser Ala Gly 
1               5                   10  


<210>  199
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  199

Gly Leu Leu Phe Ser Pro Asn Ser Ala Gly 
1               5                   10  


<210>  200
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  200

Gly Leu Leu Phe Ser Arg Met Ser Ala Arg 
1               5                   10  


<210>  201
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  201

Gly Leu Leu Phe Ser Arg Tyr Ser Ala Gly 
1               5                   10  


<210>  202
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  202

Gly Leu Leu Phe Ser Arg Asn Ile Ala Gly 
1               5                   10  


<210>  203
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  203

Gly Leu Leu Phe Ser Leu Asn Ser Ala Gly Cys Ser 
1               5                   10          


<210>  204
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  204

Gly Pro Leu Phe Arg Arg Thr Arg Ala Gly 
1               5                   10  


<210>  205
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  205

Gly Ile Pro Phe Ser Arg Asn Ser Ala Gly 
1               5                   10  


<210>  206
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  206

Gly Leu Leu Phe Arg Val Asn Ser Val Gly 
1               5                   10  


<210>  207
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  207

Gly Leu Leu Phe Arg Val Asn Ser Ala Gly 
1               5                   10  


<210>  208
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  208

Gly Leu Leu Phe Ser Val Asp Ser Ala Gly 
1               5                   10  


<210>  209
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  209

Gly Leu Leu Phe Ser Val Asn Ser Thr Val Ser 
1               5                   10      


<210>  210
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  210

Gly Leu Leu Phe Ser Val Asp Ser Thr Gly 
1               5                   10  


<210>  211
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  211

Arg Gly Thr Phe Arg Asn Phe Gly Met Gly 
1               5                   10  


<210>  212
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  212

Ala Gly Thr Phe Arg Asn Phe Gly Met Gly 
1               5                   10  


<210>  213
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  213

Gly Gly Thr Phe Arg Asn Tyr Gly Met Gly 
1               5                   10  


<210>  214
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  214

Gly Gly Thr Phe Arg Asn Phe Gly Met Gly 
1               5                   10  


<210>  215
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  215

Gly Gly Asn Phe Arg Asn Phe Gly Met Gly 
1               5                   10  


<210>  216
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  216

Ser Gly Thr Phe Arg Asn Phe Ala Met Gly 
1               5                   10  


<210>  217
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  217

Gly Gly Thr Phe Arg Asn Tyr Ala Met Gly 
1               5                   10  


<210>  218
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  218

Ala Gly Thr Leu Arg Asn Phe Gly Met Gly 
1               5                   10  


<210>  219
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  219

Lys Gly Thr Phe Arg Asn Phe Ala Met Gly 
1               5                   10  


<210>  220
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  220

Gly Gly Thr Phe Arg Asn Phe Ala Met Gly 
1               5                   10  


<210>  221
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  221

Arg Gly Thr Phe Arg Asn Phe Ala Met Gly 
1               5                   10  


<210>  222
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  222

Arg Gly Thr Phe Arg Asn Tyr Ala Met Gly 
1               5                   10  


<210>  223
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  223

Gly Gly Thr Phe Arg Ser Tyr Gly Met Gly 
1               5                   10  


<210>  224
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  224

Val Gly Asn Phe Arg Asn Phe Gly Met Gly 
1               5                   10  


<210>  225
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  225

Arg Gly Thr Phe Arg Asn Tyr Gly Met Gly 
1               5                   10  


<210>  226
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  226

Gly Gly Asn Phe Arg Asn Phe Gly Val Gly 
1               5                   10  


<210>  227
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  227

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val Ala 
1               5                   10                  


<210>  228
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  228

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val Ala 
1               5                   10                  


<210>  229
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  229

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val Ala 
1               5                   10                  


<210>  230
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  230

Trp Tyr Arg Gln Ala Pro Gly Lys Lys Arg Asp Phe Val Ala 
1               5                   10                  


<210>  231
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  231

Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val Ala 
1               5                   10                  


<210>  232
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  232

Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Phe Val Ala 
1               5                   10                  


<210>  233
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  233

Trp Tyr Arg Pro Ala Pro Gly Lys Arg Arg Glu Phe Val Ala 
1               5                   10                  


<210>  234
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  234

Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val Ala 
1               5                   10                  


<210>  235
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  235

Tyr Arg Gln Ala Pro Gly Lys Arg Pro Glu Phe Phe Ala 
1               5                   10              


<210>  236
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  236

Trp Tyr Arg Gln Gly Pro Gly Lys Arg Arg Glu Phe Val Ala 
1               5                   10                  


<210>  237
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  237

Trp Cys Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val Ala 
1               5                   10                  


<210>  238
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  238

Trp Tyr Arg Gln Ala Pro Val Lys Arg Arg Glu Phe Val Gly 
1               5                   10                  


<210>  239
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  239

Trp Tyr Arg His Ala Pro Gly Lys Gln Arg Ala Phe Val Ala 
1               5                   10                  


<210>  240
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  240

Trp Tyr Arg Gln Ala Ala Gly Lys Gln Arg Glu Phe Val Ala 
1               5                   10                  


<210>  241
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  241

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  242
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  242

Trp His Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val Ala 
1               5                   10                  


<210>  243
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  243

Trp Tyr Arg Pro Ala Pro Gly Lys Gln Arg Glu Phe Val Ala 
1               5                   10                  


<210>  244
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  244

Trp Tyr Arg Gln Asp Pro Gly Lys Gln Arg Glu Phe Val Ala 
1               5                   10                  


<210>  245
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  245

Tyr Arg Gln Ala Pro Gly Lys His Arg Glu Phe Val Ala 
1               5                   10              


<210>  246
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  246

Trp Tyr Arg Glu Ala Pro Gly Gln Gln Arg Glu Cys Val Ala 
1               5                   10                  


<210>  247
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  247

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Lys Phe Val Ala 
1               5                   10                  


<210>  248
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  248

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Leu Ala Phe Val Gly 
1               5                   10                  


<210>  249
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  249

Trp Tyr Arg Gln Ala Pro Gly Glu Gln Arg Glu Phe Val Ala 
1               5                   10                  


<210>  250
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  250

Trp Tyr Arg Gln Ala Pro Gly Gln Lys Arg Glu Phe Val Ala 
1               5                   10                  


<210>  251
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  251

Arg Gln Pro Pro Gly Lys Gln Arg Glu Phe Val Ala 
1               5                   10          


<210>  252
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  252

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Ile Phe Val Ala 
1               5                   10                  


<210>  253
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  253

Trp Tyr Arg Gln Ala Gln Gly Lys Gln Arg Glu Phe Val Ala 
1               5                   10                  


<210>  254
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  254

Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Cys Val Ala 
1               5                   10              


<210>  255
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  255

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Phe Ala 
1               5                   10                  


<210>  256
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  256

Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  257
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  257

Trp Ser Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  258
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  258

Trp Phe Arg Gln Ala Arg Gly Glu Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  259
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  259

Trp Phe Arg Gln Ala His Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  260
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  260

Trp Phe Arg Gln Asp Gln Gly Gln Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  261
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  261

Trp Phe Arg Gln Val Gln Gly Thr Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  262
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  262

Trp Phe Arg Gln Val Gln Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  263
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  263

Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Asp Phe Val Ala 
1               5                   10                  


<210>  264
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  264

Trp Phe Arg Gln Ala Gln Gly Thr Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  265
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  265

Trp Phe Arg Glu Ala Gln Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  266
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  266

Trp Phe Arg Gln Phe Gln Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  267
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 2 sequence

<400>  267

Trp Phe Arg Gln Ala Arg Gly Glu Ala Arg Glu Phe Val Ala 
1               5                   10                  


<210>  268
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  268

Arg Ile Arg Ser Gly Gly Ser Thr Asn 
1               5                   


<210>  269
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  269

Arg Ile Arg Met Gly Gly Ser Ile Asn 
1               5                   


<210>  270
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  270

Arg Ile Arg Ser Ser Gly Ser Thr Asn 
1               5                   


<210>  271
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  271

Arg Leu Arg Thr Thr Gly Ser Thr Asn 
1               5                   


<210>  272
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  272

Arg Val Arg Met Gly Gly Ser Ile Asn 
1               5                   


<210>  273
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  273

Arg Ile Arg Met Val Gly Ser Ile Asn 
1               5                   


<210>  274
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  274

Arg Thr Arg Met Gly Gly Ser Ile Asn 
1               5                   


<210>  275
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  275

Gly Val Arg Met Gly Gly Ser Ile Asn 
1               5                   


<210>  276
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  276

Arg Ile Arg Met Gly Gly Ser Thr Asn 
1               5                   


<210>  277
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  277

Cys Ile Arg Met Gly Gly Ser Ile Asn 
1               5                   


<210>  278
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  278

Arg Ile Arg Met Gly Gly Ser Met Asn 
1               5                   


<210>  279
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  279

Arg Ile Arg Arg Gly Gly Gly Ile Asn 
1               5                   


<210>  280
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  280

Arg Ile Gly Met Gly Gly Cys Ile Asn 
1               5                   


<210>  281
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  281

Arg Ser Arg Met Gly Gly Ser Ile Asn 
1               5                   


<210>  282
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  282

Arg Ile Arg Thr Gly Gly Ser Thr Asn 
1               5                   


<210>  283
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  283

Arg Ile Leu Met Gly Gly Ser Ile Asn 
1               5                   


<210>  284
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  284

Arg Ile Arg Met Gly Gly Ser Arg Asn 
1               5                   


<210>  285
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  285

Arg Ile Arg Arg Gly Gly Asp Thr Asn 
1               5                   


<210>  286
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  286

Arg Leu Arg Arg Gly Gly Asp Thr Asn 
1               5                   


<210>  287
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  287

Arg Ile Arg Arg Gly Gly Ser Thr Asn 
1               5                   


<210>  288
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  288

Arg Leu Arg Arg Gly Gly Glu Thr Asn 
1               5                   


<210>  289
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  289

Arg Ile Arg Ser Gly Gly Ser Ile Asn 
1               5                   


<210>  290
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  290

Ala Ile Ser Arg Ser Gly Gly His Lys Tyr 
1               5                   10  


<210>  291
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  291

Thr Ile Ser Arg Ser Ala Arg His Thr Tyr 
1               5                   10  


<210>  292
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  292

Ala Ile Ser Arg Ser Ala Gly Arg Thr Tyr 
1               5                   10  


<210>  293
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  293

Ala Ile Ser Arg Ser Ala Ser Arg Thr Tyr 
1               5                   10  


<210>  294
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  294

Ala Ile Ser Arg Ser Gly Gly His Ile Tyr 
1               5                   10  


<210>  295
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  295

Ala Ile Ser Arg Ser Gly Gly Arg Thr Tyr 
1               5                   10  


<210>  296
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  296

Thr Ile Ser Arg Ser Gly Gly His Thr Tyr 
1               5                   10  


<210>  297
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  297

Ala Ile Ser Arg Ser Ala Gly His Thr Tyr 
1               5                   10  


<210>  298
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  298

Ala Ile Ser Arg Thr Gly Gly Arg Thr Tyr 
1               5                   10  


<210>  299
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  299

Thr Ile Ser Arg Ser Gly Gly Tyr Thr Tyr 
1               5                   10  


<210>  300
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  300

Ala Ile Ser Arg Ser Gly Gly His Thr Tyr 
1               5                   10  


<210>  301
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  301

Ala Ile Ser Arg Ser Gly Gly His Ile Phe 
1               5                   10  


<210>  302
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  302

Ala Ile Ser Arg Ser Gly Gly Arg Lys Tyr 
1               5                   10  


<210>  303
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  303

Ala Ile Ser Arg Thr Gly Gly His Thr Tyr 
1               5                   10  


<210>  304
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  304

Ala Ile Ser Arg Thr Asn Gly His Ile Tyr 
1               5                   10  


<210>  305
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  305

Thr Ile Ser Arg Ser Gly Gly His Ile Tyr 
1               5                   10  


<210>  306
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  306

Ala Val Ser Arg Thr Gly Gly Arg Thr Tyr 
1               5                   10  


<210>  307
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  307

Thr Ile Ser Arg Ser Gly Gly His Ile Phe 
1               5                   10  


<210>  308
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  308

Ala Ile Ser Arg Ala Gly Gly Arg Thr Tyr 
1               5                   10  


<210>  309
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  309

Ala Ile Ser Arg Ser Ala Gly His Ile Tyr 
1               5                   10  


<210>  310
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  310

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala 
1               5                   10                  15      


Thr Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  311
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  311

Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  312
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  312

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala 
1               5                   10                  15      


Thr Asn Thr Val His Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Gly Ser 
        35                  


<210>  313
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  313

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala 
1               5                   10                  15      


Thr Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  314
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  314

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala 
1               5                   10                  15      


Thr Asn Thr Leu Tyr Leu Gln Val Asn Asn Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  315
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  315

Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ala Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Gly Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  316
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  316

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  317
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  317

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Ser Gly 
        35                  


<210>  318
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  318

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Ile Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  319
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  319

Tyr Ala Gln Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ala 
        35                  


<210>  320
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  320

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Lys Tyr Phe Cys Ser Ser 
        35                  


<210>  321
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  321

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Met Tyr Leu Leu Met Asn Asp Leu Asn Arg Glu Tyr Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Ser Gly 
        35                  


<210>  322
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  322

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Met Tyr Leu Gln Met Ile Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Thr Val Tyr Cys Cys Ser Gly 
        35                  


<210>  323
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  323

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Gly Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Gly Tyr Phe Cys Ser Gly 
        35                  


<210>  324
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  324

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Met Tyr Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Cys Leu Cys Ser Gly 
        35                  


<210>  325
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  325

Tyr Ala Asp Ser Gly Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Ser Gly 
        35                  


<210>  326
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  326

Tyr Gly Asp Ala Val Lys Gly Arg Phe Thr Ala Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Ile Tyr Phe Cys Ser Ser 
        35                  


<210>  327
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  327

Tyr Gly Val Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Pro Gln Met Asn Asp Leu Lys Pro Glu Asp Ala 
            20                  25                  30          


Ala Lys Tyr Phe Cys Ser Ser 
        35                  


<210>  328
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  328

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Arg Met Asn Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Ile Tyr Phe Cys Ser Ser 
        35                  


<210>  329
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  329

Tyr Gly Gly Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Ser Ser 
        35                  


<210>  330
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  330

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  331
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  331

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Val Asp Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Ile Tyr Phe Cys Ser Ser 
        35                  


<210>  332
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  332

Tyr Gly Gly Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Glu Thr 
            20                  25                  30          


Ala Trp Tyr Phe Cys Ser Ser 
        35                  


<210>  333
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  333

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asp Thr Arg Tyr Met Gln Ile Asn Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Lys Tyr Phe Cys Arg Ser 
        35                  


<210>  334
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  334

Asp Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Ile Tyr Phe Cys Arg Ser 
        35                  


<210>  335
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  335

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Glu Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Lys Tyr Leu Cys Arg Ser 
        35                  


<210>  336
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  336

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ala Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Glu Thr 
            20                  25                  30          


Ala Ile Tyr Phe Cys Ser Ser 
        35                  


<210>  337
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  337

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Asp Val Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Lys Tyr Phe Cys Ser Ser 
        35                  


<210>  338
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  338

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Tyr Thr 
            20                  25                  30          


Ala Ile Tyr Phe Cys Ser Ser 
        35                  


<210>  339
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  339

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu His Thr 
            20                  25                  30          


Ala Lys Tyr Leu Cys Ser Ser 
        35                  


<210>  340
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  340

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Ile Tyr Phe Cys Ser Ser 
        35                  


<210>  341
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  341

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Lys Tyr Phe Cys Ser Ser 
        35                  


<210>  342
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  342

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Thr Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Lys Tyr Phe Cys Ser Ser 
        35                  


<210>  343
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  343

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Glu Tyr Phe Cys Ser Ser 
        35                  


<210>  344
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  344

Asp Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Asp 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asn Thr 
            20                  25                  30          


Ala Lys Tyr Phe Cys Ser Ser 
        35                  


<210>  345
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  345

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Gly Asn Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  346
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  346

Tyr Gly Asp Ser Val Lys Gly Arg Phe Asn Gly Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asp Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Ile Cys Phe Cys Ser Ser 
        35                  


<210>  347
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  347

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Lys Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Lys Tyr Phe Cys Ser Arg 
        35                  


<210>  348
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  348

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Gly Asp Ile Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Lys 
        


<210>  349
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  349

Tyr Ala Glu Ser Val Arg Gly Arg Phe Thr Val Ser Arg Asp Lys Ala 
1               5                   10                  15      


Lys Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ser 
        35                  


<210>  350
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  350

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ala 
        35                  


<210>  351
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  351

Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ala 
        35                  


<210>  352
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  352

Tyr Ala Asp Ser Val Lys Gly Arg Ser Thr Val Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Leu Tyr Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  353
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  353

Tyr Ala Asp Thr Val Lys Gly Arg Val Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Ser Pro Ala Asp Thr 
            20                  25                  30          


Gly Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  354
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  354

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala 
1               5                   10                  15      


Thr Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  355
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  355

Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Gln Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Ser Pro Glu Asp Thr 
            20                  25                  30          


Ala Ala Tyr Tyr Cys Ser Ser 
        35                  


<210>  356
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  356

Asp Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  357
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  357

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys His Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  358
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  358

Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala 
1               5                   10                  15      


Thr Asn Thr Leu Tyr Leu Gln Met Ser Asn Leu Asn Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ser Ser 
        35                  


<210>  359
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  359

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  360
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  360

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  361
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  361

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala 
1               5                   10                  15      


Lys Asn Ile Met Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  362
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  362

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Ala Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  363
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  363

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Ser Cys Ala Ala 
        35                  


<210>  364
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  364

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala 
1               5                   10                  15      


Lys Asn Val Met Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  365
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  365

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Leu Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  366
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  366

Phe Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Ile Leu Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  367
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  367

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  368
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  368

Phe Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  369
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  369

Tyr Ser Asp Ser Val Gln Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  370
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  370

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Ile Met Ser Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  371
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  371

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Ile Tyr Tyr Cys Ala Ala 
        35                  


<210>  372
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  372

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Lys Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Asp Tyr Tyr Cys Ala Ala 
        35                  


<210>  373
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  373

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Ile Leu Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  374
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  374

Tyr Ser Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala 
1               5                   10                  15      


Lys Asn Ile Met Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  375
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  375

Tyr Ser Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Leu Val Ser Leu Gln Met Asn Ser Leu Asn Ala Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  376
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  376

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Ile Leu Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  377
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  377

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Ile Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  378
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  378

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Tyr Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Gly 
        35                  


<210>  379
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  379

Tyr Ser Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Met Ser Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  380
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  380

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  381
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  381

Phe Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  382
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  382

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ala Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  383
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  383

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Ser Cys Ala Ala 
        35                  


<210>  384
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  384

Tyr Gln Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Ile Leu Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  385
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  385

Tyr Ser Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  386
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  386

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Ile Met Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  387
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  387

Tyr Ala Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Thr Cys Ala Ala 
        35                  


<210>  388
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  388

Phe Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Leu Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  389
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  389

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Leu Val Ser Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  390
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  390

Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Ala Tyr Tyr Cys Ala Ala 
        35                  


<210>  391
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  391

Tyr Ser Asp Ser Val Lys Gly Arg Ser Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Met Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  392
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  392

Tyr Leu Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Asn Ile Leu Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  393
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  393

Trp Arg Thr Gly Ala Tyr Glu Tyr 
1               5               


<210>  394
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  394

Trp Arg Thr Gly Phe Tyr Glu Tyr 
1               5               


<210>  395
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  395

Trp Arg Thr Glu Ala Tyr Glu Tyr 
1               5               


<210>  396
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  396

Trp Arg Thr Gly Ala Tyr Glu His 
1               5               


<210>  397
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  397

Trp Arg Glu Gly Phe Tyr Glu Tyr 
1               5               


<210>  398
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  398

Trp Arg Ile Glu Ala Tyr Glu Tyr 
1               5               


<210>  399
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  399

Trp Arg Glu Gly Phe Phe Glu Tyr 
1               5               


<210>  400
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  400

Trp Arg Glu Gly Phe Tyr Gly Tyr 
1               5               


<210>  401
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  401

Trp Arg Lys Gly Phe Tyr Glu Tyr 
1               5               


<210>  402
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  402

Trp Arg Gly Gly Phe Tyr Glu Tyr 
1               5               


<210>  403
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  403

Trp Arg Glu Gly Leu Tyr Glu Tyr 
1               5               


<210>  404
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  404

Trp Arg Glu Gly Phe Tyr Glu Ser 
1               5               


<210>  405
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  405

Trp Arg Glu Gly Val Tyr Lys Tyr 
1               5               


<210>  406
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  406

Trp Arg Glu Gly Tyr Tyr Glu Tyr 
1               5               


<210>  407
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  407

Trp Arg Glu Gly Phe Asp Glu Tyr 
1               5               


<210>  408
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  408

Trp Arg Glu Gly Phe Tyr Lys Tyr 
1               5               


<210>  409
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  409

Gly Arg Glu Gly Phe Tyr Glu Tyr 
1               5               


<210>  410
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  410

Asp Phe Gly Ser Ser Trp Arg Glu Gly Phe Tyr Glu Tyr 
1               5                   10              


<210>  411
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  411

Trp Arg Thr Gly Ser Tyr Glu Tyr 
1               5               


<210>  412
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  412

Trp Arg Ala Gly Thr Tyr Glu Tyr 
1               5               


<210>  413
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  413

Trp Arg Glu Gly Ala Tyr Glu Tyr 
1               5               


<210>  414
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  414

Trp Arg Ile Asp Ala Tyr Glu Tyr 
1               5               


<210>  415
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  415

Trp Arg Ile Gly Ser Tyr Glu Tyr 
1               5               


<210>  416
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  416

Arg Phe Arg Phe Asp Asp Gly Thr Ser Tyr Tyr Gln Arg Ala Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  417
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  417

Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  418
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  418

Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  419
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  419

Arg Phe Arg Phe Asp Asp Asp Thr Tyr Tyr Tyr Gln Arg Ala Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  420
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  420

Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Thr Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  421
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  421

Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Asn Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  422
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  422

Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  423
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  423

Arg Phe Arg Ser Asp Gly Gly Thr Tyr Tyr Tyr Gln Arg Ala Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  424
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  424

Arg Phe Arg Tyr Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  425
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  425

Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Arg Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  426
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  426

Arg Phe Arg Ser Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  427
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  427

Arg Phe Arg Ser Asp Asp Asp Thr Tyr Tyr Tyr Gln Arg Ala Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  428
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  428

Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Thr Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  429
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  429

Arg Phe Arg Phe Gly Asp Gly Ala Tyr Tyr Tyr Gln Arg Thr Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  430
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  430

Arg Phe Arg Phe Asp Asp Gly Thr Tyr Phe Tyr Gln Arg Ala Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  431
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  431

Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Asn Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  432
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  432

Arg Phe Arg Phe Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala Phe Tyr 
1               5                   10                  15      


Asn Leu 
        


<210>  433
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  433

Arg Phe Arg Ser Asp Asp Gly Thr Tyr Tyr Tyr Gln Arg Ile Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  434
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  434

Arg Phe Arg Ser Gly Asp Gly Thr Ser Tyr Tyr Glu Arg Ala Phe Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  435
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  435

Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Asn Phe Tyr 
1               5                   10                  15      


Gly Phe 
        


<210>  436
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  436

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  437
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  437

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  438
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  438

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  439
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  439

Trp Gly Gln Gly Ala Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  440
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  440

Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  441
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  441

Trp Gly Gln Val Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  442
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  442

Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  443
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  443

Trp Arg Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  444
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  444

Trp Ser Gln Arg Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  445
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  445

Gly Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  446
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  446

Trp Ala Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  447
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  447

Trp Cys Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  448
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  448

Trp Gly Ile Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  449
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  449

Cys Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  450
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 4 sequence

<400>  450

Trp Gly Gln Trp Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  451
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  451

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly His Thr Tyr Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ile Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                165                 170                 175     


Gly Leu Val Gln Ala Gly Gly Ser Leu Ser Leu Ser Cys Thr Ala Ser 
            180                 185                 190         


Gly Gly Thr Phe Arg Asn Phe Gly Met Gly Trp Phe Arg Gln Ala Gln 
        195                 200                 205             


Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Thr Gly Gly His 
    210                 215                 220                 


Thr Tyr Tyr Gln Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp 
225                 230                 235                 240 


Asn Ala Lys Asn Ile Leu Ser Leu Gln Met Asn Ser Leu Lys Pro Glu 
                245                 250                 255     


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Phe Arg Phe Gly Asp Gly 
            260                 265                 270         


Thr Tyr Tyr Tyr Gln Arg Ala Phe Tyr Asp Phe Trp Gly Gln Gly Thr 
        275                 280                 285             


Gln Val Thr Val Ser Ser 
    290                 


<210>  452
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  452

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ser Ser Trp Arg Thr Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265         


<210>  453
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  453

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Ser Leu Ser Cys Thr Ala Ser 
                165                 170                 175     


Gly Gly Thr Phe Arg Asn Phe Gly Met Gly Trp Phe Arg Gln Ala Gln 
            180                 185                 190         


Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Thr Gly Gly His 
        195                 200                 205             


Thr Tyr Tyr Gln Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp 
    210                 215                 220                 


Asn Ala Lys Asn Ile Leu Ser Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Phe Arg Phe Gly Asp Gly 
                245                 250                 255     


Thr Tyr Tyr Tyr Gln Arg Ala Phe Tyr Asp Phe Trp Gly Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser 
        275             


<210>  454
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  454

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly His Thr Tyr Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ile Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
                165                 170                 175     


Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser 
            180                 185                 190         


Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        195                 200                 205             


Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr 
    210                 215                 220                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Ser Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser 
        275             


<210>  455
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  455

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Ser Leu Ser Cys Thr Ala Ser 
                165                 170                 175     


Gly Gly Thr Phe Arg Asn Phe Gly Met Gly Trp Phe Arg Gln Ala Gln 
            180                 185                 190         


Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Thr Gly Gly His 
        195                 200                 205             


Thr Tyr Tyr Gln Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp 
    210                 215                 220                 


Asn Ala Lys Asn Ile Leu Ser Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Phe Arg Phe Gly Asp Gly 
                245                 250                 255     


Thr Tyr Tyr Tyr Gln Arg Ala Phe Tyr Asp Phe Trp Gly Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser 
        275             


<210>  456
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  456

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ser Ser Trp Arg Thr Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265         


<210>  457
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  457

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Gly Thr Phe Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Thr Gly Gly His Thr Tyr Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ile Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Arg Phe Gly Asp Gly Thr Tyr Tyr Tyr Gln Arg Ala 
            100                 105                 110         


Phe Tyr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
                165                 170                 175     


Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser 
            180                 185                 190         


Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        195                 200                 205             


Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr 
    210                 215                 220                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Ser Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser 
        275             


<210>  458
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  458

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ser Ser Trp Arg Thr Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
305                 310                 315                 320 


Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn Ser Ala 
                325                 330                 335     


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val Ala Arg 
            340                 345                 350         


Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys Gly Arg 
        355                 360                 365             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
    370                 375                 380                 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser Ser Trp 
385                 390                 395                 400 


Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser 
        


<210>  459
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  459

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ser Ser Trp Arg Thr Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
305                 310                 315                 320 


Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn Ser Ala 
                325                 330                 335     


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val Ala Arg 
            340                 345                 350         


Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys Gly Arg 
        355                 360                 365             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
    370                 375                 380                 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser Ser Trp 
385                 390                 395                 400 


Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            420                 425                 430         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        435                 440                 445             


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    450                 455                 460                 


Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu 
465                 470                 475                 480 


Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
                485                 490                 495     


Gln Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr 
            500                 505                 510         


Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        515                 520                 525             


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
    530                 535                 540                 


Val Tyr Tyr Cys Ser Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly 
545                 550                 555                 560 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                565                 


<210>  460
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  460

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Arg Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Met Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Phe Cys Ser Gly Trp Arg Glu Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265         


<210>  461
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  461

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Leu Arg Thr Thr Gly Ser Thr Asn Tyr Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ala Trp Arg Ile Glu Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Val Asn Ser Val Gly Trp Tyr Arg Arg Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Leu Arg Thr Thr Gly Ser Thr 
        195                 200                 205             


Asn Tyr Ala Gln Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ser Ala Trp Arg Ile Glu Ala Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser 
    


<210>  462
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  462

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Arg Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Met Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Phe Cys Ser Gly Trp Arg Glu Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser 
    


<210>  463
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  463

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Val Asn 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Arg Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Leu Arg Thr Thr Gly Ser Thr Asn Tyr Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ala Trp Arg Ile Glu Ala Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
                165                 170                 175     


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
    210                 215                 220                 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ser 
            260                 265                 270         


Ala Ser Gly Leu Leu Phe Ser Val Asn Ser Val Gly Trp Tyr Arg Arg 
        275                 280                 285             


Ala Pro Gly Lys Gln Arg Glu Phe Val Ala Arg Leu Arg Thr Thr Gly 
    290                 295                 300                 


Ser Thr Asn Tyr Ala Gln Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Ala Trp Arg Ile Glu Ala Tyr 
            340                 345                 350         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365 


<210>  464
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  464

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
                165                 170                 175     


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
    210                 215                 220                 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser 
            260                 265                 270         


Ala Ser Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly 
    290                 295                 300                 


Ser Ile Asn Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Ser Trp Arg Thr Gly Phe Tyr 
            340                 345                 350         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365 


<210>  465
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  465

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ser Ser Trp Arg Thr Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser 
    


<210>  466
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  466

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
                165                 170                 175     


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
    210                 215                 220                 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser 
            260                 265                 270         


Ala Ser Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Arg Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly 
    290                 295                 300                 


Ser Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg 
305                 310                 315                 320 


Asp Asn Ala Lys Asn Met Met Tyr Leu Gln Met Asn Asp Leu Lys Pro 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Phe Cys Ser Gly Trp Arg Glu Gly Phe Tyr 
            340                 345                 350         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365 


<210>  467
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody sequence

<400>  467

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Arg Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Met Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Phe Cys Ser Gly Trp Arg Glu Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser 
    


<210>  468
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  468

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Gly 
    130                 135                 140                 


Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly 
145                 150                 155                 160 


Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val Ala Arg Ile 
                165                 170                 175     


Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu Gln Met Asn 
        195                 200                 205             


Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser Gly Trp Arg 
    210                 215                 220                 


Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        275                 280                 285             


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
    290                 295                 300                 


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
                325                 330                 335     


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
            340                 345                 350         


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
        355                 360                 365             


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser 
385                 390     


<210>  469
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  469

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe 
145                 150                 155                 160 


Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg 
                165                 170                 175     


Glu Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp 
            180                 185                 190         


Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met 
        195                 200                 205             


Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Phe Cys Ser Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        275                 280                 285             


Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                325                 330                 335     


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
    370                 375                 380                 


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395         


<210>  470
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  470

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    130                 135                 140                 


Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala 
145                 150                 155                 160 


Ser Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Arg Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly Ser 
            180                 185                 190         


Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp 
        195                 200                 205             


Asn Ala Lys Asn Met Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu 
    210                 215                 220                 


Asp Thr Ala Val Tyr Phe Cys Ser Gly Trp Arg Glu Gly Phe Tyr Glu 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    290                 295                 300                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
305                 310                 315                 320 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                325                 330                 335     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        355                 360                 365             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    370                 375                 380                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser 
        


<210>  471
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  471

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    130                 135                 140                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Gly 
145                 150                 155                 160 


Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly 
                165                 170                 175     


Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val Ala Arg Ile 
            180                 185                 190         


Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        195                 200                 205             


Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu Gln Met Asn 
    210                 215                 220                 


Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser Gly Trp Arg 
225                 230                 235                 240 


Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    290                 295                 300                 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
305                 310                 315                 320 


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                325                 330                 335     


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
            340                 345                 350         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        355                 360                 365             


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
    370                 375                 380                 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
385                 390                 395                 400 


Thr Leu Val Thr Val Ser Ser 
                405         


<210>  472
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  472

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu 
                165                 170                 175     


Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp 
            180                 185                 190         


Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val Ala Arg Ile Arg 
        195                 200                 205             


Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu Gln Met Asn Asp 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser Gly Trp Arg Glu 
                245                 250                 255     


Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
305                 310                 315                 320 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                325                 330                 335     


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            340                 345                 350         


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
        355                 360                 365             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
    370                 375                 380                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
385                 390                 395                 400 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
                405                 410                 415     


Leu Val Thr Val Ser Ser 
            420         


<210>  473
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  473

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp 
        195                 200                 205             


Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 


Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser 
                245                 250                 255     


Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    290                 295                 300                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Gly 
305                 310                 315                 320 


Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly 
                325                 330                 335     


Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val Ala Arg Ile 
            340                 345                 350         


Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        355                 360                 365             


Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu Gln Met Asn 
    370                 375                 380                 


Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser Gly Trp Arg 
385                 390                 395                 400 


Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser 
    


<210>  474
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  474

Met Asp Glu Arg Leu Ser Leu Leu Arg Ser Pro Pro Pro Pro Ser Ala 
1               5                   10                  15      


Arg His Arg Ala His Pro Pro Gln Arg Pro Ala Ser Ser Gly Gly Ala 
            20                  25                  30          


His Thr Leu Val Asn His Gly Tyr Ala Glu Pro Ala Ala Gly Arg Glu 
        35                  40                  45              


Leu Pro Pro Asp Met Thr Val Val Pro Gly Asp His Leu Leu Glu Pro 
    50                  55                  60                  


Glu Val Ala Asp Gly Gly Gly Ala Pro Pro Gln Gly Gly Cys Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Asp Arg Tyr Glu Pro Leu Pro Pro Ser Leu Pro Ala Ala 
                85                  90                  95      


Gly Glu Gln Asp Cys Cys Gly Glu Arg Val Val Ile Asn Ile Ser Gly 
            100                 105                 110         


Leu Arg Phe Glu Thr Gln Leu Lys Thr Leu Cys Gln Phe Pro Glu Thr 
        115                 120                 125             


Leu Leu Gly Asp Pro Lys Arg Arg Met Arg Tyr Phe Asp Pro Leu Arg 
    130                 135                 140                 


Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu 
145                 150                 155                 160 


Tyr Tyr Tyr Gln Ser Gly Gly Arg Ile Arg Arg Pro Val Asn Val Pro 
                165                 170                 175     


Ile Asp Ile Phe Ser Glu Glu Ile Arg Phe Tyr Gln Leu Gly Glu Glu 
            180                 185                 190         


Ala Met Glu Lys Phe Arg Glu Asp Glu Gly Phe Leu Arg Glu Glu Glu 
        195                 200                 205             


Arg Pro Leu Pro Arg Arg Asp Phe Gln Arg Gln Val Trp Leu Leu Phe 
    210                 215                 220                 


Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile Ala Ile Val Ser 
225                 230                 235                 240 


Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu 
                245                 250                 255     


Pro Glu Phe Arg Asp Glu Lys Asp Tyr Pro Ala Ser Thr Ser Gln Asp 
            260                 265                 270         


Ser Phe Glu Ala Ala Gly Asn Ser Thr Ser Gly Ser Arg Ala Gly Ala 
        275                 280                 285             


Ser Ser Phe Ser Asp Pro Phe Phe Val Val Glu Thr Leu Cys Ile Ile 
    290                 295                 300                 


Trp Phe Ser Phe Glu Leu Leu Val Arg Phe Phe Ala Cys Pro Ser Lys 
305                 310                 315                 320 


Ala Thr Phe Ser Arg Asn Ile Met Asn Leu Ile Asp Ile Val Ala Ile 
                325                 330                 335     


Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Arg Gln Gly 
            340                 345                 350         


Asn Gly Gln Gln Ala Met Ser Leu Ala Ile Leu Arg Val Ile Arg Leu 
        355                 360                 365             


Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu 
    370                 375                 380                 


Gln Ile Leu Gly Gln Thr Leu Lys Ala Ser Met Arg Glu Leu Gly Leu 
385                 390                 395                 400 


Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala Val 
                405                 410                 415     


Tyr Phe Ala Glu Ala Asp Asp Pro Thr Ser Gly Phe Ser Ser Ile Pro 
            420                 425                 430         


Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly 
        435                 440                 445             


Asp Met His Pro Val Thr Ile Gly Gly Lys Ile Val Gly Ser Leu Cys 
    450                 455                 460                 


Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val 
465                 470                 475                 480 


Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Gly Glu Glu Gln 
                485                 490                 495     


Ser Gln Tyr Met His Val Gly Ser Cys Gln His Leu Ser Ser Ser Ala 
            500                 505                 510         


Glu Glu Leu Arg Lys Ala Arg Ser Asn Ser Thr Leu Ser Lys Ser Glu 
        515                 520                 525             


Tyr Met Val Ile Glu Glu Gly Gly Met Asn His Ser Ala Phe Pro Gln 
    530                 535                 540                 


Thr Pro Phe Lys Thr Gly Asn Ser Thr Ala Thr Cys Thr Thr Asn Asn 
545                 550                 555                 560 


Asn Pro Asn Ser Cys Val Asn Ile Lys Lys Ile Phe Thr Asp Val 
                565                 570                 575 


<210>  475
<211>  525
<212>  PRT
<213>  Rattus norvegicus

<400>  475

Met Thr Val Val Pro Gly Asp His Leu Leu Glu Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Gly Gly Gly Asp Pro Pro Gln Gly Gly Cys Val Ser Gly Gly Gly 
            20                  25                  30          


Cys Asp Arg Tyr Glu Pro Leu Pro Pro Ala Leu Pro Ala Ala Gly Glu 
        35                  40                  45              


Gln Asp Cys Cys Gly Glu Arg Val Val Ile Asn Ile Ser Gly Leu Arg 
    50                  55                  60                  


Phe Glu Thr Gln Leu Lys Thr Leu Cys Gln Phe Pro Glu Thr Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Lys Arg Arg Met Arg Tyr Phe Asp Pro Leu Arg Asn Glu 
                85                  90                  95      


Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr 
            100                 105                 110         


Tyr Gln Ser Gly Gly Arg Ile Arg Arg Pro Val Asn Val Pro Ile Asp 
        115                 120                 125             


Ile Phe Ser Glu Glu Ile Arg Phe Tyr Gln Leu Gly Glu Glu Ala Met 
    130                 135                 140                 


Glu Lys Phe Arg Glu Asp Glu Gly Phe Leu Arg Glu Glu Glu Arg Pro 
145                 150                 155                 160 


Leu Pro Arg Arg Asp Phe Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr 
                165                 170                 175     


Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile Ala Ile Val Ser Val Leu 
            180                 185                 190         


Val Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu 
        195                 200                 205             


Phe Arg Asp Glu Lys Asp Tyr Pro Ala Ser Pro Ser Gln Asp Val Phe 
    210                 215                 220                 


Glu Ala Ala Asn Asn Ser Thr Ser Gly Ala Ser Ser Gly Ala Ser Ser 
225                 230                 235                 240 


Phe Ser Asp Pro Phe Phe Val Val Glu Thr Leu Cys Ile Ile Trp Phe 
                245                 250                 255     


Ser Phe Glu Leu Leu Val Arg Phe Phe Ala Cys Pro Ser Lys Ala Thr 
            260                 265                 270         


Phe Ser Arg Asn Ile Met Asn Leu Ile Asp Ile Val Ala Ile Ile Pro 
        275                 280                 285             


Tyr Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Arg Gln Gly Asn Gly 
    290                 295                 300                 


Gln Gln Ala Met Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg 
305                 310                 315                 320 


Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile 
                325                 330                 335     


Leu Gly Gln Thr Leu Lys Ala Ser Met Arg Glu Leu Gly Leu Leu Ile 
            340                 345                 350         


Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala Val Tyr Phe 
        355                 360                 365             


Ala Glu Ala Asp Asp Pro Ser Ser Gly Phe Asn Ser Ile Pro Asp Ala 
    370                 375                 380                 


Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met 
385                 390                 395                 400 


His Pro Val Thr Ile Gly Gly Lys Ile Val Gly Ser Leu Cys Ala Ile 
                405                 410                 415     


Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val Ser Asn 
            420                 425                 430         


Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Gly Glu Glu Gln Ala Gln 
        435                 440                 445             


Tyr Met His Val Gly Ser Cys Gln His Leu Ser Ser Ser Ala Glu Glu 
    450                 455                 460                 


Leu Arg Lys Ala Arg Ser Asn Ser Thr Leu Ser Lys Ser Glu Tyr Met 
465                 470                 475                 480 


Val Ile Glu Glu Gly Gly Met Asn His Ser Ala Phe Pro Gln Thr Pro 
                485                 490                 495     


Phe Lys Thr Gly Asn Ser Thr Ala Thr Cys Thr Thr Asn Asn Asn Pro 
            500                 505                 510         


Asn Ser Cys Val Asn Ile Lys Lys Ile Phe Thr Asp Val 
        515                 520                 525 


<210>  476
<211>  528
<212>  PRT
<213>  Mus musculus

<400>  476

Met Thr Val Val Pro Gly Asp His Leu Leu Glu Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Gly Gly Gly Asp Pro Pro Gln Gly Gly Cys Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Cys Asp Arg Tyr Glu Pro Leu Pro Pro Ala Leu Pro Ala 
        35                  40                  45              


Ala Gly Glu Gln Asp Cys Cys Gly Glu Arg Val Val Ile Asn Ile Ser 
    50                  55                  60                  


Gly Leu Arg Phe Glu Thr Gln Leu Lys Thr Leu Cys Gln Phe Pro Glu 
65                  70                  75                  80  


Thr Leu Leu Gly Asp Pro Lys Arg Arg Met Arg Tyr Phe Asp Pro Leu 
                85                  90                  95      


Arg Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile 
            100                 105                 110         


Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg Ile Arg Arg Pro Val Asn Val 
        115                 120                 125             


Pro Ile Asp Ile Phe Ser Glu Glu Ile Arg Phe Tyr Gln Leu Gly Glu 
    130                 135                 140                 


Glu Ala Met Glu Lys Phe Arg Glu Asp Glu Gly Phe Leu Arg Glu Glu 
145                 150                 155                 160 


Glu Arg Pro Leu Pro Arg Arg Asp Phe Gln Arg Gln Val Trp Leu Leu 
                165                 170                 175     


Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile Ala Ile Val 
            180                 185                 190         


Ser Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr 
        195                 200                 205             


Leu Pro Glu Phe Arg Asp Glu Lys Asp Tyr Pro Ala Ser Pro Ser Gln 
    210                 215                 220                 


Asp Val Phe Glu Ala Ala Asn Asn Ser Thr Ser Gly Ala Pro Ser Gly 
225                 230                 235                 240 


Ala Ser Ser Phe Ser Asp Pro Phe Phe Val Val Glu Thr Leu Cys Ile 
                245                 250                 255     


Ile Trp Phe Ser Phe Glu Leu Leu Val Arg Phe Phe Ala Cys Pro Ser 
            260                 265                 270         


Lys Ala Thr Phe Ser Arg Asn Ile Met Asn Leu Ile Asp Ile Val Ala 
        275                 280                 285             


Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Arg Gln 
    290                 295                 300                 


Gly Asn Gly Gln Gln Ala Met Ser Leu Ala Ile Leu Arg Val Ile Arg 
305                 310                 315                 320 


Leu Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly 
                325                 330                 335     


Leu Gln Ile Leu Gly Gln Thr Leu Lys Ala Ser Met Arg Glu Leu Gly 
            340                 345                 350         


Leu Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala 
        355                 360                 365             


Val Tyr Phe Ala Glu Ala Asp Asp Pro Ser Ser Gly Phe Asn Ser Ile 
    370                 375                 380                 


Pro Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr 
385                 390                 395                 400 


Gly Asp Met His Pro Val Thr Ile Gly Gly Lys Ile Val Gly Ser Leu 
                405                 410                 415     


Cys Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile 
            420                 425                 430         


Val Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Gly Glu Glu 
        435                 440                 445             


Gln Ala Gln Tyr Met His Val Gly Ser Cys Gln His Leu Ser Ser Ser 
    450                 455                 460                 


Ala Glu Glu Leu Arg Lys Ala Arg Ser Asn Ser Thr Leu Ser Lys Ser 
465                 470                 475                 480 


Glu Tyr Met Val Ile Glu Glu Gly Gly Met Asn His Ser Ala Phe Pro 
                485                 490                 495     


Gln Thr Pro Phe Lys Thr Gly Asn Ser Thr Ala Thr Cys Thr Thr Asn 
            500                 505                 510         


Asn Asn Pro Asn Ser Cys Val Asn Ile Lys Lys Ile Phe Thr Asp Val 
        515                 520                 525             


<210>  477
<211>  575
<212>  PRT
<213>  Macaca fascicularis

<400>  477

Met Asp Glu His Leu Ser Leu Leu Arg Ser Pro Pro Pro Pro Ser Ala 
1               5                   10                  15      


Arg His Arg Ala His Pro Ala Gln Arg Pro Ala Ser Ser Gly Gly Ala 
            20                  25                  30          


His Thr Leu Val Asn Pro Gly Tyr Ala Glu Pro Ala Ala Gly Pro Glu 
        35                  40                  45              


Leu Pro Pro Asp Met Thr Val Val Pro Gly Asp His Leu Leu Glu Pro 
    50                  55                  60                  


Glu Val Ala Asp Gly Gly Gly Ala Pro Pro Gln Gly Gly Cys Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Asp Arg Tyr Glu Pro Leu Pro Pro Ser Leu Pro Ala Ala 
                85                  90                  95      


Gly Glu Gln Asp Cys Cys Gly Glu Arg Val Val Ile Asn Ile Ser Gly 
            100                 105                 110         


Leu Arg Phe Glu Thr Gln Leu Lys Thr Leu Cys Gln Phe Pro Glu Thr 
        115                 120                 125             


Leu Leu Gly Asp Pro Lys Arg Arg Met Arg Tyr Phe Asp Pro Leu Arg 
    130                 135                 140                 


Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu 
145                 150                 155                 160 


Tyr Tyr Tyr Gln Ser Gly Gly Arg Ile Arg Arg Pro Val Asn Val Pro 
                165                 170                 175     


Ile Asp Ile Phe Ser Glu Glu Ile Arg Phe Tyr Gln Leu Gly Glu Glu 
            180                 185                 190         


Ala Met Glu Lys Phe Arg Glu Asp Glu Gly Phe Leu Arg Glu Glu Glu 
        195                 200                 205             


Arg Pro Leu Pro Arg Arg Asp Phe Gln Arg Gln Val Trp Leu Leu Phe 
    210                 215                 220                 


Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile Ala Ile Val Ser 
225                 230                 235                 240 


Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu 
                245                 250                 255     


Pro Glu Phe Arg Asp Glu Lys Asp Tyr Pro Ala Ser Pro Ser Gln Asp 
            260                 265                 270         


Ser Phe Asp Ala Ala Gly Asn Ser Thr Ser Gly Ala Ala Ala Gly Ala 
        275                 280                 285             


Ser Ser Phe Ser Asp Pro Phe Phe Val Val Glu Thr Leu Cys Ile Ile 
    290                 295                 300                 


Trp Phe Ser Phe Glu Leu Leu Val Arg Phe Phe Ala Cys Pro Ser Lys 
305                 310                 315                 320 


Ala Thr Phe Ser Arg Asn Ile Met Asn Leu Ile Asp Ile Val Ala Ile 
                325                 330                 335     


Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Arg Gln Gly 
            340                 345                 350         


Asn Gly Gln Gln Ala Met Ser Leu Ala Ile Leu Arg Val Ile Arg Leu 
        355                 360                 365             


Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu 
    370                 375                 380                 


Gln Ile Leu Gly Gln Thr Leu Lys Ala Ser Met Arg Glu Leu Gly Leu 
385                 390                 395                 400 


Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala Val 
                405                 410                 415     


Tyr Phe Ala Glu Ala Asp Asp Pro Thr Ser Gly Phe Ser Ser Ile Pro 
            420                 425                 430         


Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly 
        435                 440                 445             


Asp Met His Pro Val Thr Ile Gly Gly Lys Ile Val Gly Ser Leu Cys 
    450                 455                 460                 


Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val 
465                 470                 475                 480 


Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Gly Glu Glu Gln 
                485                 490                 495     


Ala Gln Tyr Met His Val Gly Ser Cys Gln His Leu Ser Ser Ser Ala 
            500                 505                 510         


Glu Glu Leu Arg Lys Ala Arg Ser Asn Ser Thr Leu Ser Lys Ser Glu 
        515                 520                 525             


Tyr Met Val Ile Glu Glu Gly Gly Met Asn His Ser Ala Phe Pro Gln 
    530                 535                 540                 


Thr Pro Phe Lys Thr Gly Asn Ser Thr Ala Thr Cys Thr Thr Asn Asn 
545                 550                 555                 560 


Asn Pro Asn Ser Cys Val Asn Ile Lys Lys Ile Phe Thr Asp Val 
                565                 570                 575 


<210>  478
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody sequence

<400>  478

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  479
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  479

Gly Gly Gly Gly Ser 
1               5   


<210>  480
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  480

Ser Gly Gly Ser Gly Gly Ser 
1               5           


<210>  481
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  481

Gly Gly Gly Gly Cys Gly Gly Gly Ser 
1               5                   


<210>  482
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  482

Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  483
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  483

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  484
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  484

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  485
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  485

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  486
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  486

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  487
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  487

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  488
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  488

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  489
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  489

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  490
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  490

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210>  491
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  491

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  492
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  492

Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Pro Lys Ser Cys Asp Lys 
1               5                   10                  15      


Thr His Thr Cys Pro Pro Cys Pro 
            20                  


<210>  493
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  493

Glu Pro Lys Thr Pro Lys Pro Gln Pro Ala Ala Ala 
1               5                   10          


<210>  494
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  494

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          


<210>  495
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  495

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  496
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  496

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Arg Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Met Met Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Phe Cys Ser Gly Trp Arg Glu Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  497
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  497

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Met Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Gly Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Met Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ser Ser Trp Arg Thr Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  498
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  498

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ala Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  499
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  499

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Glu Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  500
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  500

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Phe Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  501
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  501

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Gly Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  502
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  502

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg His Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  503
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  503

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Lys Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  504
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  504

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Leu Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  505
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  505

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Pro Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  506
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  506

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Gln Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  507
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  507

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Arg Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  508
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  508

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  509
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  509

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  510
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  510

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Val Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  511
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  511

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Trp Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  512
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  512

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Tyr Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  513
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  513

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ile Gly Gly Ser Ile Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  514
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  514

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Gln Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Gln Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Leu Tyr Tyr Cys Ser Gly Trp Arg Thr Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  515
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  515

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Gln Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Gln Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Leu Tyr Tyr Cys Ser Ser Trp Arg Glu Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  516
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  516

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ala Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Ala Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Leu Tyr Tyr Cys Ser Gly Trp Arg Thr Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  517
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  517

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ala Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Ala Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Leu Tyr Tyr Cys Ser Ser Trp Arg Glu Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  518
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  518

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ala Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Ala Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Leu Tyr Tyr Cys Ser Gly Trp Arg Glu Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  519
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  519

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Tyr Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Tyr Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Leu Tyr Tyr Cys Ser Gly Trp Arg Thr Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  520
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  520

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Tyr Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Tyr Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Leu Tyr Tyr Cys Ser Ser Trp Arg Glu Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  521
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  521

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Tyr Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Tyr Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Leu Tyr Tyr Cys Ser Gly Trp Arg Glu Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  522
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  522

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Gln Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Gly Leu Leu Phe Ser Arg Asn Ser Ala Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Phe Val Ala Arg Ile Arg Gln Gly Gly Ser Ile 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Leu Tyr Tyr Cys Ser Gly Trp Arg Glu Gly Phe Tyr Glu Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  523
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  523

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ala Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  524
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  524

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ala Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  525
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  525

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ala Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  526
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  526

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Gln Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  527
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  527

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Gln Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  528
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  528

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Gln Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  529
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  529

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Tyr Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  530
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  530

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Tyr Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  531
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  531

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Tyr Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  532
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  532

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ala Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  533
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  533

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ala Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  534
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  534

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Ala Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  535
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  535

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Gln Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  536
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  536

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Gln Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  537
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  537

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Gln Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  538
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  538

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Tyr Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Thr Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  539
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  539

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Tyr Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Ser Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  540
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequency

<400>  540

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Leu Leu Phe Ser Arg Asn 
            20                  25                  30          


Ser Ala Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Arg Tyr Gly Gly Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ser 
                85                  90                  95      


Gly Trp Arg Glu Gly Phe Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  541
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  541

Arg Ile Arg Ala Gly Gly Ser Ile Asn 
1               5                   


<210>  542
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  542

Arg Ile Arg Glu Gly Gly Ser Ile Asn 
1               5                   


<210>  543
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  543

Arg Ile Arg Phe Gly Gly Ser Ile Asn 
1               5                   


<210>  544
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  544

Arg Ile Arg Gly Gly Gly Ser Ile Asn 
1               5                   


<210>  545
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  545

Arg Ile Arg His Gly Gly Ser Ile Asn 
1               5                   


<210>  546
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  546

Arg Ile Arg Lys Gly Gly Ser Ile Asn 
1               5                   


<210>  547
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  547

Arg Ile Arg Leu Gly Gly Ser Ile Asn 
1               5                   


<210>  548
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  548

Arg Ile Arg Pro Gly Gly Ser Ile Asn 
1               5                   


<210>  549
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  549

Arg Ile Arg Gln Gly Gly Ser Ile Asn 
1               5                   


<210>  550
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  550

Arg Ile Arg Arg Gly Gly Ser Ile Asn 
1               5                   


<210>  551
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  551

Arg Ile Arg Thr Gly Gly Ser Ile Asn 
1               5                   


<210>  552
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  552

Arg Ile Arg Val Gly Gly Ser Ile Asn 
1               5                   


<210>  553
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  553

Arg Ile Arg Trp Gly Gly Ser Ile Asn 
1               5                   


<210>  554
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  554

Arg Ile Arg Tyr Gly Gly Ser Ile Asn 
1               5                   


<210>  555
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  555

Arg Ile Arg Ile Gly Gly Ser Ile Asn 
1               5                   


<210>  556
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  556

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser 
            20                  25  


<210>  557
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  557

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          


Ala Leu Tyr Tyr Cys Ser Gly 
        35                  


<210>  558
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 3 sequence

<400>  558

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            20                  25                  30          


Ala Leu Tyr Tyr Cys Ser Ser 
        35                  


<210>  559
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework 1 sequence

<400>  559

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser 
            20                  25  


