                         SEQUENCE LISTING

<110>  EUROPEAN MOLECULAR BIOLOGY LABORATORY
       UNIVERSITE JOSEPH FOURIER
 
<120>  FLUORESCENT AMP-KINASE BIOSENSORS

<130>  WOB 15 UJF KINA

<150>  EP14173018.4
<151>  2014-06-18

<160>  99    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  putative alpha helix

<400>  1

Glu Glu Glu Glu Lys Lys Lys Lys 
1               5               


<210>  2
<211>  4260
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rat alpha2 subunit pACE plasmid

<400>  2
ggaattccag ataacttcgt ataatgtatg ctatacgaag ttatggtacc gcggccgcgt       60

agaggatctg ttgatcagca gttcaacctg ttgatagtac ttcgttaata cagatgtagg      120

tgttggcacc atgcataact ataacggtcc taaggtagcg acctaggtat cgataatacg      180

actcactata ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa      240

ctttaagaag gagatataat gggcagtagt caccatcacc accaccatca tcaccatcat      300

agtagtgaaa acctgtattt tcaggggcat atggctgaga agcagaagca cgacgggcgt      360

gtgaagatcg gacactacgt gctgggggac accctgggcg tcggcacctt cggcaaagtg      420

aagattggag aacatcaatt gacaggccat aaagtggcag ttaagatctt aaatagacag      480

aagattcgca gtttagatgt tgttggaaaa ataaaacgag aaattcaaaa tcttaaactc      540

tttcgtcatc ctcatattat caaactctac caagtgatca gcactccaac agactttttt      600

atggtaatgg aatatgtgtc tggaggtgaa ttgttcgact acatctgtaa acacgggagg      660

gttgaagagg tggaagctcg ccggctcttc cagcagattc tgtctgccgt ggactactgt      720

cacaggcaca tggttgtcca cagggacctg aagccagaga acgtgttgct ggacgcccag      780

atgaatgcta agatagctga cttcggactc tctaatatga tgtcagatgg tgaatttcta      840

cgaactagct gtggatcgcc aaattatgca gcaccggagg tcatctcagg aaggctgtat      900

gcgggtcctg aggttgatat ctggagctgt ggtgttatcc tgtatgccct tctctgtggc      960

accctcccgt tcgacgatga gcacgtgcct acgctcttta agaagatccg agggggtgtg     1020

ttctacatcc cggagtatct caaccgttct attgccactc tgctgatgca catgctgcag     1080

gtggacccct tgaagcgagc aactatcaaa gacatacgag agcatgaatg gtttaaacag     1140

gatttgccca gttacctctt tcctgaagac ccctcctatg atgctaacgt cattgatgat     1200

gaggctgtga aagaagtatg tgaaaaattt gagtgtacag aatcagaagt gatgaacagt     1260

ttatacagtg gtgaccctca agaccagctc gcagtggctt atcatctcat cattgacaat     1320

cggagaataa tgaaccaagc cagtgagttc tacctcgcct ccagtcctcc aacgggttcc     1380

ttcatggacg atatggccat gcacattccc cccggcctga aaccacatcc tgaaaggatg     1440

ccacctctca tagcagacag ccccaaagca cgctgtccac tggatgcact caacacaact     1500

aagcccaaat ctttagctgt gaaaaaagcc aagtggcacc ttgggatccg aagccagagc     1560

aaaccatacg acattatggc ggaggtgtac cgagctatga agcagctgga ctttgaatgg     1620

aaggtagtga atgcatacca tcttcgagta agaagaaaaa acccagtgac tggcaattac     1680

gtgaaaatga gcttacagct ttacctggtt gacaatcgga gctatctgct ggactttaaa     1740

agcatcgatg atgaggtggt ggagcagagg tctggttctt caacacctca gcgctcctgt     1800

tctgctgccg gcctccacag acctcggtca agtgtcgatt ccagcacagc cgagaaccat     1860

tcactgtctg gctctctcac tggttctttg actggcagca ctttgtcctc cgcttccccg     1920

cgcctgggca gtcataccat ggattttttt gaaatgtgcg ccagtcttat cactgcttta     1980

gcccgtaagc tttaactcga gagatccggc tgctaacaaa gcccgaaagg aagctgagtt     2040

ggctgctgcc accgctgagc aataactagc ataacccctt ggggcctcta aacgggtctt     2100

gaggggtttt ttggtttaaa cccatctaat tggactagta gcccgcctaa tgagcgggct     2160

tttttttaat tcccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat     2220

gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca     2280

acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca     2340

cccagaaacg ctcgtgaaag taaaagacgc agaggaccaa ttgggggcac gagtgggata     2400

catagaactg gacttgaata gcggtaaaat ccttgagagt tttcgccctg aagagcgttt     2460

tccaatgatg agcactttca aagttctgct atgtggagca gtattatccc gtgtagatgc     2520

ggggcaagag caactcggac gacgaataca ctattcgcag aatgacttgg ttgaatactc     2580

cccagtgaca gaaaagcacc ttacggacgg aatgacggta agagaattat gtagtgccgc     2640

cataacgatg agtgataaca ctgcggcgaa cttacttctg acaaccatcg gtggaccgaa     2700

ggaattaacc gcttttttgc acaatatggg agaccatgta actcgccttg accgttggga     2760

accagaactg aatgaagcca taccaaacga cgagcgagac accacaatgc ctgcggcaat     2820

ggcaacaaca ttacgcaaac tattaactgg cgaactactt actctggctt cacggcaaca     2880

attaatagac tggcttgaag cggataaagt tgcaggacca ctactgcgtt cggcacttcc     2940

tgctggctgg tttattgctg ataaatctgg ggcaggagag cgtggttcac ggggtatcat     3000

tgccgcactt ggaccagatg gtaagccttc ccgtatcgta gttatctaca cgacgggtag     3060

tcaggcaact atggacgaac gaaatagaca gattgctgaa ataggggctt cactgattaa     3120

gcattggtaa accgatacaa ttaaaggctc cttttggagc cttttttttt ggacggaccg     3180

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg     3240

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact     3300

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg     3360

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg     3420

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac     3480

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca     3540

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga     3600

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc     3660

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct     3720

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg     3780

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct     3840

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc     3900

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc     3960

gaggaagcgg aagagcgcct gatgcggtat tttctcctta cgcatctgtg cggtatttca     4020

caccgcaatg gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagtata     4080

cactccgcta tcgctacgtg actgggtcat ggctgcgccc cgacacccgc caacacccgc     4140

tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt     4200

ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgaggcaggg     4260


<210>  3
<211>  578
<212>  PRT
<213>  Homo Sapiens

<400>  3

Met Gly Ser Ser His His His His His His His His His His Ser Ser 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly His Met Ala Glu Lys Gln Lys His Asp 
            20                  25                  30          


Gly Arg Val Lys Ile Gly His Tyr Val Leu Gly Asp Thr Leu Gly Val 
        35                  40                  45              


Gly Thr Phe Gly Lys Val Lys Ile Gly Glu His Gln Leu Thr Gly His 
    50                  55                  60                  


Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg Ser Leu Asp 
65                  70                  75                  80  


Val Val Gly Lys Ile Lys Arg Glu Ile Gln Asn Leu Lys Leu Phe Arg 
                85                  90                  95      


His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr Pro Thr Asp 
            100                 105                 110         


Phe Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu Phe Asp Tyr 
        115                 120                 125             


Ile Cys Lys His Gly Arg Val Glu Glu Val Glu Ala Arg Arg Leu Phe 
    130                 135                 140                 


Gln Gln Ile Leu Ser Ala Val Asp Tyr Cys His Arg His Met Val Val 
145                 150                 155                 160 


His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala Gln Met Asn 
                165                 170                 175     


Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser Asp Gly Glu 
            180                 185                 190         


Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala Pro Glu Val 
        195                 200                 205             


Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile Trp Ser Cys 
    210                 215                 220                 


Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro Phe Asp Asp 
225                 230                 235                 240 


Glu His Val Pro Thr Leu Phe Lys Lys Ile Arg Gly Gly Val Phe Tyr 
                245                 250                 255     


Ile Pro Glu Tyr Leu Asn Arg Ser Ile Ala Thr Leu Leu Met His Met 
            260                 265                 270         


Leu Gln Val Asp Pro Leu Lys Arg Ala Thr Ile Lys Asp Ile Arg Glu 
        275                 280                 285             


His Glu Trp Phe Lys Gln Asp Leu Pro Ser Tyr Leu Phe Pro Glu Asp 
    290                 295                 300                 


Pro Ser Tyr Asp Ala Asn Val Ile Asp Asp Glu Ala Val Lys Glu Val 
305                 310                 315                 320 


Cys Glu Lys Phe Glu Cys Thr Glu Ser Glu Val Met Asn Ser Leu Tyr 
                325                 330                 335     


Ser Gly Asp Pro Gln Asp Gln Leu Ala Val Ala Tyr His Leu Ile Ile 
            340                 345                 350         


Asp Asn Arg Arg Ile Met Asn Gln Ala Ser Glu Phe Tyr Leu Ala Ser 
        355                 360                 365             


Ser Pro Pro Thr Gly Ser Phe Met Asp Asp Met Ala Met His Ile Pro 
    370                 375                 380                 


Pro Gly Leu Lys Pro His Pro Glu Arg Met Pro Pro Leu Ile Ala Asp 
385                 390                 395                 400 


Ser Pro Lys Ala Arg Cys Pro Leu Asp Ala Leu Asn Thr Thr Lys Pro 
                405                 410                 415     


Lys Ser Leu Ala Val Lys Lys Ala Lys Trp His Leu Gly Ile Arg Ser 
            420                 425                 430         


Gln Ser Lys Pro Tyr Asp Ile Met Ala Glu Val Tyr Arg Ala Met Lys 
        435                 440                 445             


Gln Leu Asp Phe Glu Trp Lys Val Val Asn Ala Tyr His Leu Arg Val 
    450                 455                 460                 


Arg Arg Lys Asn Pro Val Thr Gly Asn Tyr Val Lys Met Ser Leu Gln 
465                 470                 475                 480 


Leu Tyr Leu Val Asp Asn Arg Ser Tyr Leu Leu Asp Phe Lys Ser Ile 
                485                 490                 495     


Asp Asp Glu Val Val Glu Gln Arg Ser Gly Ser Ser Thr Pro Gln Arg 
            500                 505                 510         


Ser Cys Ser Ala Ala Gly Leu His Arg Pro Arg Ser Ser Val Asp Ser 
        515                 520                 525             


Ser Thr Ala Glu Asn His Ser Leu Ser Gly Ser Leu Thr Gly Ser Leu 
    530                 535                 540                 


Thr Gly Ser Thr Leu Ser Ser Ala Ser Pro Arg Leu Gly Ser His Thr 
545                 550                 555                 560 


Met Asp Phe Phe Glu Met Cys Ala Ser Leu Ile Thr Ala Leu Ala Arg 
                565                 570                 575     


Lys Leu 
        


<210>  4
<211>  5007
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rat alpha2-eCFP pACE plasmid

<400>  4
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa      600

cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc      660

gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg      720

ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcctgat      780

gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcaatggtg cactctcagt      840

acaatctgct ctgatgccgc atagttaagc cagtatacac tccgctatcg ctacgtgact      900

gggtcatggc tgcgccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc      960

tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga     1020

ggttttcacc gtcatcaccg aaacgcgcga ggcaggggga attccagata acttcgtata     1080

atgtatgcta tacgaagtta tggtaccgcg gccgcgtaga ggatctgttg atcagcagtt     1140

caacctgttg atagtacttc gttaatacag atgtaggtgt tggcaccatg cataactata     1200

acggtcctaa ggtagcgacc taggtatcga taatacgact cactataggg gaattgtgag     1260

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atataatggg     1320

cagtagtcac catcaccacc accatcatca ccatcatagt agtgaaaacc tgtattttca     1380

ggggcatatg gctgagaagc agaagcacga cgggcgtgtg aagatcggac actacgtgct     1440

gggggacacc ctgggcgtcg gcaccttcgg caaagtgaag attggagaac atcaattgac     1500

aggccataaa gtggcagtta agatcttaaa tagacagaag attcgcagtt tagatgttgt     1560

tggaaaaata aaacgagaaa ttcaaaatct taaactcttt cgtcatcctc atattatcaa     1620

actctaccaa gtgatcagca ctccaacaga cttttttatg gtaatggaat atgtgtctgg     1680

aggtgaattg ttcgactaca tctgtaaaca cgggagggtt gaagaggtgg aagctcgccg     1740

gctcttccag cagattctgt ctgccgtgga ctactgtcac aggcacatgg ttgtccacag     1800

ggacctgaag ccagagaacg tgttgctgga cgcccagatg aatgctaaga tagctgactt     1860

cggactctct aatatgatgt cagatggtga atttctacga actagctgtg gatcgccaaa     1920

ttatgcagca ccggaggtca tctcaggaag gctgtatgcg ggtcctgagg ttgatatctg     1980

gagctgtggt gttatcctgt atgcccttct ctgtggcacc ctcccgttcg acgatgagca     2040

cgtgcctacg ctctttaaga agatccgagg gggtgtgttc tacatcccgg agtatctcaa     2100

ccgttctatt gccactctgc tgatgcacat gctgcaggtg gaccccttga agcgagcaac     2160

tatcaaagac atacgagagc atgaatggtt taaacaggat ttgcccagtt acctctttcc     2220

tgaagacccc tcctatgatg ctaacgtcat tgatgatgag gctgtgaaag aagtatgtga     2280

aaaatttgag tgtacagaat cagaagtgat gaacagttta tacagtggtg accctcaaga     2340

ccagctcgca gtggcttatc atctcatcat tgacaatcgg agaataatga accaagccag     2400

tgagttctac ctcgcctcca gtcctccaac gggttccttc atggacgata tggccatgca     2460

cattcccccc ggcctgaaac cacatcctga aaggatgcca cctctcatag cagacagccc     2520

caaagcacgc tgtccactgg atgcactcaa cacaactaag cccaaatctt tagctgtgaa     2580

aaaagccaag tggcaccttg ggatccgaag ccagagcaaa ccatacgaca ttatggcgga     2640

ggtgtaccga gctatgaagc agctggactt tgaatggaag gtagtgaatg cataccatct     2700

tcgagtaaga agaaaaaacc cagtgactgg caattacgtg aaaatgagct tacagcttta     2760

cctggttgac aatcggagct atctgctgga ctttaaaagc atcgatgatg aggtggtgga     2820

gcagaggtct ggttcttcaa cacctcagcg ctcctgttct gctgccggcc tccacagacc     2880

tcggtcaagt gtcgattcca gcacagccga gaaccattca ctgtctggct ctctcactgg     2940

ttctttgact ggcagcactt tgtcctccgc ttccccgcgc ctgggcagtc ataccatgga     3000

tttttttgaa atgtgcgcca gtcttatcac tgctttagcc cgtaagctta tggtgagcaa     3060

gggcgaggag ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa     3120

cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac     3180

cctgaagttc atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac     3240

cctgacctgg ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt     3300

cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga     3360

cggcaactac aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat     3420

cgagctgaag ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta     3480

caactacatc agccacaacg tctatatcac cgccgacaag cagaagaacg gcatcaaggc     3540

caacttcaag atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca     3600

gcagaacacc cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac     3660

ccagtccgcc ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt     3720

cgtgaccgcc gccgggatca ctctcggcat ggacgagctg tacaagtccg gactcagatc     3780

tcgacgagct cactgataac tcgagagatc cggctgctaa caaagcccga aaggaagctg     3840

agttggctgc tgccaccgct gagcaataac tagcataacc ccttggggcc tctaaacggg     3900

tcttgagggg ttttttggtt taaacccatc taattggact agtagcccgc ctaatgagcg     3960

ggcttttttt taattcccct atttgtttat ttttctaaat acattcaaat atgtatccgc     4020

tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta     4080

ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg     4140

ctcacccaga aacgctcgtg aaagtaaaag acgcagagga ccaattgggg gcacgagtgg     4200

gatacataga actggacttg aatagcggta aaatccttga gagttttcgc cctgaagagc     4260

gttttccaat gatgagcact ttcaaagttc tgctatgtgg agcagtatta tcccgtgtag     4320

atgcggggca agagcaactc ggacgacgaa tacactattc gcagaatgac ttggttgaat     4380

actccccagt gacagaaaag caccttacgg acggaatgac ggtaagagaa ttatgtagtg     4440

ccgccataac gatgagtgat aacactgcgg cgaacttact tctgacaacc atcggtggac     4500

cgaaggaatt aaccgctttt ttgcacaata tgggagacca tgtaactcgc cttgaccgtt     4560

gggaaccaga actgaatgaa gccataccaa acgacgagcg agacaccaca atgcctgcgg     4620

caatggcaac aacattacgc aaactattaa ctggcgaact acttactctg gcttcacggc     4680

aacaattaat agactggctt gaagcggata aagttgcagg accactactg cgttcggcac     4740

ttcctgctgg ctggtttatt gctgataaat ctggggcagg agagcgtggt tcacggggta     4800

tcattgccgc acttggacca gatggtaagc cttcccgtat cgtagttatc tacacgacgg     4860

gtagtcaggc aactatggac gaacgaaata gacagattgc tgaaataggg gcttcactga     4920

ttaagcattg gtaaaccgat acaattaaag gctccttttg gagccttttt ttttggacgg     4980

accggtagaa aagatcaaag gatcttc                                         5007


<210>  5
<211>  826
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rat alpha2-eCFP

<400>  5

Met Gly Ser Ser His His His His His His His His His His Ser Ser 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly His Met Ala Glu Lys Gln Lys His Asp 
            20                  25                  30          


Gly Arg Val Lys Ile Gly His Tyr Val Leu Gly Asp Thr Leu Gly Val 
        35                  40                  45              


Gly Thr Phe Gly Lys Val Lys Ile Gly Glu His Gln Leu Thr Gly His 
    50                  55                  60                  


Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg Ser Leu Asp 
65                  70                  75                  80  


Val Val Gly Lys Ile Lys Arg Glu Ile Gln Asn Leu Lys Leu Phe Arg 
                85                  90                  95      


His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr Pro Thr Asp 
            100                 105                 110         


Phe Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu Phe Asp Tyr 
        115                 120                 125             


Ile Cys Lys His Gly Arg Val Glu Glu Val Glu Ala Arg Arg Leu Phe 
    130                 135                 140                 


Gln Gln Ile Leu Ser Ala Val Asp Tyr Cys His Arg His Met Val Val 
145                 150                 155                 160 


His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala Gln Met Asn 
                165                 170                 175     


Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser Asp Gly Glu 
            180                 185                 190         


Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala Pro Glu Val 
        195                 200                 205             


Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile Trp Ser Cys 
    210                 215                 220                 


Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro Phe Asp Asp 
225                 230                 235                 240 


Glu His Val Pro Thr Leu Phe Lys Lys Ile Arg Gly Gly Val Phe Tyr 
                245                 250                 255     


Ile Pro Glu Tyr Leu Asn Arg Ser Ile Ala Thr Leu Leu Met His Met 
            260                 265                 270         


Leu Gln Val Asp Pro Leu Lys Arg Ala Thr Ile Lys Asp Ile Arg Glu 
        275                 280                 285             


His Glu Trp Phe Lys Gln Asp Leu Pro Ser Tyr Leu Phe Pro Glu Asp 
    290                 295                 300                 


Pro Ser Tyr Asp Ala Asn Val Ile Asp Asp Glu Ala Val Lys Glu Val 
305                 310                 315                 320 


Cys Glu Lys Phe Glu Cys Thr Glu Ser Glu Val Met Asn Ser Leu Tyr 
                325                 330                 335     


Ser Gly Asp Pro Gln Asp Gln Leu Ala Val Ala Tyr His Leu Ile Ile 
            340                 345                 350         


Asp Asn Arg Arg Ile Met Asn Gln Ala Ser Glu Phe Tyr Leu Ala Ser 
        355                 360                 365             


Ser Pro Pro Thr Gly Ser Phe Met Asp Asp Met Ala Met His Ile Pro 
    370                 375                 380                 


Pro Gly Leu Lys Pro His Pro Glu Arg Met Pro Pro Leu Ile Ala Asp 
385                 390                 395                 400 


Ser Pro Lys Ala Arg Cys Pro Leu Asp Ala Leu Asn Thr Thr Lys Pro 
                405                 410                 415     


Lys Ser Leu Ala Val Lys Lys Ala Lys Trp His Leu Gly Ile Arg Ser 
            420                 425                 430         


Gln Ser Lys Pro Tyr Asp Ile Met Ala Glu Val Tyr Arg Ala Met Lys 
        435                 440                 445             


Gln Leu Asp Phe Glu Trp Lys Val Val Asn Ala Tyr His Leu Arg Val 
    450                 455                 460                 


Arg Arg Lys Asn Pro Val Thr Gly Asn Tyr Val Lys Met Ser Leu Gln 
465                 470                 475                 480 


Leu Tyr Leu Val Asp Asn Arg Ser Tyr Leu Leu Asp Phe Lys Ser Ile 
                485                 490                 495     


Asp Asp Glu Val Val Glu Gln Arg Ser Gly Ser Ser Thr Pro Gln Arg 
            500                 505                 510         


Ser Cys Ser Ala Ala Gly Leu His Arg Pro Arg Ser Ser Val Asp Ser 
        515                 520                 525             


Ser Thr Ala Glu Asn His Ser Leu Ser Gly Ser Leu Thr Gly Ser Leu 
    530                 535                 540                 


Thr Gly Ser Thr Leu Ser Ser Ala Ser Pro Arg Leu Gly Ser His Thr 
545                 550                 555                 560 


Met Asp Phe Phe Glu Met Cys Ala Ser Leu Ile Thr Ala Leu Ala Arg 
                565                 570                 575     


Lys Leu Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
            580                 585                 590         


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
        595                 600                 605             


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
    610                 615                 620                 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
625                 630                 635                 640 


Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
                645                 650                 655     


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
            660                 665                 670         


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
        675                 680                 685             


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
    690                 695                 700                 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
705                 710                 715                 720 


Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln 
                725                 730                 735     


Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
            740                 745                 750         


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
        755                 760                 765             


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
    770                 775                 780                 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
785                 790                 795                 800 


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
                805                 810                 815     


Lys Ser Gly Leu Arg Ser Arg Arg Ala His 
            820                 825     


<210>  6
<211>  5010
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rat eCFP-alpha2, pACE plasmid

<400>  6
ggaattccag ataacttcgt ataatgtatg ctatacgaag ttatggtacc gcggccgcgt       60

agaggatctg ttgatcagca gttcaacctg ttgatagtac ttcgttaata cagatgtagg      120

tgttggcacc atgcataact ataacggtcc taaggtagcg acctaggtat cgataatacg      180

actcactata ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa      240

ctttaagaag gagatataat gggcagtagt caccatcacc accaccatca tcaccatcat      300

agtagtgaaa acctgtattt tcaggggcat atggtgagca agggcgagga gctgttcacc      360

ggggtggtgc ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg      420

tccggcgagg gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc      480

accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca ccctgacctg gggcgtgcag      540

tgcttcagcc gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc      600

gaaggctacg tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc      660

gccgaggtga agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac      720

ttcaaggagg acggcaacat cctggggcac aagctggagt acaactacat cagccacaac      780

gtctatatca ccgccgacaa gcagaagaac ggcatcaagg ccaacttcaa gatccgccac      840

aacatcgagg acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc      900

gacggccccg tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa      960

gaccccaacg agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc     1020

actctcggca tggacgagct gtacaagtcc ggactcagat ctcgacgagc tcacggcggt     1080

atggctgaga agcagaagca cgacgggcgt gtgaagatcg gacactacgt gctgggggac     1140

accctgggcg tcggcacctt cggcaaagtg aagattggag aacatcaatt gacaggccat     1200

aaagtggcag ttaagatctt aaatagacag aagattcgca gtttagatgt tgttggaaaa     1260

ataaaacgag aaattcaaaa tcttaaactc tttcgtcatc ctcatattat caaactctac     1320

caagtgatca gcactccaac agactttttt atggtaatgg aatatgtgtc tggaggtgaa     1380

ttgttcgact acatctgtaa acacgggagg gttgaagagg tggaagctcg ccggctcttc     1440

cagcagattc tgtctgccgt ggactactgt cacaggcaca tggttgtcca cagggacctg     1500

aagccagaga acgtgttgct ggacgcccag atgaatgcta agatagctga cttcggactc     1560

tctaatatga tgtcagatgg tgaatttcta cgaactagct gtggatcgcc aaattatgca     1620

gcaccggagg tcatctcagg aaggctgtat gcgggtcctg aggttgatat ctggagctgt     1680

ggtgttatcc tgtatgccct tctctgtggc accctcccgt tcgacgatga gcacgtgcct     1740

acgctcttta agaagatccg agggggtgtg ttctacatcc cggagtatct caaccgttct     1800

attgccactc tgctgatgca catgctgcag gtggacccct tgaagcgagc aactatcaaa     1860

gacatacgag agcatgaatg gtttaaacag gatttgccca gttacctctt tcctgaagac     1920

ccctcctatg atgctaacgt cattgatgat gaggctgtga aagaagtatg tgaaaaattt     1980

gagtgtacag aatcagaagt gatgaacagt ttatacagtg gtgaccctca agaccagctc     2040

gcagtggctt atcatctcat cattgacaat cggagaataa tgaaccaagc cagtgagttc     2100

tacctcgcct ccagtcctcc aacgggttcc ttcatggacg atatggccat gcacattccc     2160

cccggcctga aaccacatcc tgaaaggatg ccacctctca tagcagacag ccccaaagca     2220

cgctgtccac tggatgcact caacacaact aagcccaaat ctttagctgt gaaaaaagcc     2280

aagtggcacc ttgggatccg aagccagagc aaaccatacg acattatggc ggaggtgtac     2340

cgagctatga agcagctgga ctttgaatgg aaggtagtga atgcatacca tcttcgagta     2400

agaagaaaaa acccagtgac tggcaattac gtgaaaatga gcttacagct ttacctggtt     2460

gacaatcgga gctatctgct ggactttaaa agcatcgatg atgaggtggt ggagcagagg     2520

tctggttctt caacacctca gcgctcctgt tctgctgccg gcctccacag acctcggtca     2580

agtgtcgatt ccagcacagc cgagaaccat tcactgtctg gctctctcac tggttctttg     2640

actggcagca ctttgtcctc cgcttccccg cgcctgggca gtcataccat ggattttttt     2700

gaaatgtgcg ccagtcttat cactgcttta gcccgtaagc tttaactcga gagatccggc     2760

tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactagc     2820

ataacccctt ggggcctcta aacgggtctt gaggggtttt ttggtttaaa cccatctaat     2880

tggactagta gcccgcctaa tgagcgggct tttttttaat tcccctattt gtttattttt     2940

ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata     3000

atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt     3060

tgcggcattt tgccttcctg tttttgctca cccagaaacg ctcgtgaaag taaaagacgc     3120

agaggaccaa ttgggggcac gagtgggata catagaactg gacttgaata gcggtaaaat     3180

ccttgagagt tttcgccctg aagagcgttt tccaatgatg agcactttca aagttctgct     3240

atgtggagca gtattatccc gtgtagatgc ggggcaagag caactcggac gacgaataca     3300

ctattcgcag aatgacttgg ttgaatactc cccagtgaca gaaaagcacc ttacggacgg     3360

aatgacggta agagaattat gtagtgccgc cataacgatg agtgataaca ctgcggcgaa     3420

cttacttctg acaaccatcg gtggaccgaa ggaattaacc gcttttttgc acaatatggg     3480

agaccatgta actcgccttg accgttggga accagaactg aatgaagcca taccaaacga     3540

cgagcgagac accacaatgc ctgcggcaat ggcaacaaca ttacgcaaac tattaactgg     3600

cgaactactt actctggctt cacggcaaca attaatagac tggcttgaag cggataaagt     3660

tgcaggacca ctactgcgtt cggcacttcc tgctggctgg tttattgctg ataaatctgg     3720

ggcaggagag cgtggttcac ggggtatcat tgccgcactt ggaccagatg gtaagccttc     3780

ccgtatcgta gttatctaca cgacgggtag tcaggcaact atggacgaac gaaatagaca     3840

gattgctgaa ataggggctt cactgattaa gcattggtaa accgatacaa ttaaaggctc     3900

cttttggagc cttttttttt ggacggaccg gtagaaaaga tcaaaggatc ttcttgagat     3960

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     4020

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     4080

gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac     4140

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     4200

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     4260

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     4320

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     4380

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     4440

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     4500

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     4560

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     4620

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     4680

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgcct gatgcggtat     4740

tttctcctta cgcatctgtg cggtatttca caccgcaatg gtgcactctc agtacaatct     4800

gctctgatgc cgcatagtta agccagtata cactccgcta tcgctacgtg actgggtcat     4860

ggctgcgccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc     4920

ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc     4980

accgtcatca ccgaaacgcg cgaggcaggg                                      5010


<210>  7
<211>  828
<212>  PRT
<213>  Homo Sapiens

<400>  7

Met Gly Ser Ser His His His His His His His His His His Ser Ser 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly His Met Val Ser Lys Gly Glu Glu Leu 
            20                  25                  30          


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        35                  40                  45              


Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
    50                  55                  60                  


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
65                  70                  75                  80  


Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Trp Gly Val Gln Cys Phe 
                85                  90                  95      


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            100                 105                 110         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
        115                 120                 125             


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    130                 135                 140                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
145                 150                 155                 160 


Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr 
                165                 170                 175     


Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile 
            180                 185                 190         


Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
        195                 200                 205             


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
    210                 215                 220                 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
225                 230                 235                 240 


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
                245                 250                 255     


Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Arg Arg Ala His 
            260                 265                 270         


Gly Gly Met Ala Glu Lys Gln Lys His Asp Gly Arg Val Lys Ile Gly 
        275                 280                 285             


His Tyr Val Leu Gly Asp Thr Leu Gly Val Gly Thr Phe Gly Lys Val 
    290                 295                 300                 


Lys Ile Gly Glu His Gln Leu Thr Gly His Lys Val Ala Val Lys Ile 
305                 310                 315                 320 


Leu Asn Arg Gln Lys Ile Arg Ser Leu Asp Val Val Gly Lys Ile Lys 
                325                 330                 335     


Arg Glu Ile Gln Asn Leu Lys Leu Phe Arg His Pro His Ile Ile Lys 
            340                 345                 350         


Leu Tyr Gln Val Ile Ser Thr Pro Thr Asp Phe Phe Met Val Met Glu 
        355                 360                 365             


Tyr Val Ser Gly Gly Glu Leu Phe Asp Tyr Ile Cys Lys His Gly Arg 
    370                 375                 380                 


Val Glu Glu Val Glu Ala Arg Arg Leu Phe Gln Gln Ile Leu Ser Ala 
385                 390                 395                 400 


Val Asp Tyr Cys His Arg His Met Val Val His Arg Asp Leu Lys Pro 
                405                 410                 415     


Glu Asn Val Leu Leu Asp Ala Gln Met Asn Ala Lys Ile Ala Asp Phe 
            420                 425                 430         


Gly Leu Ser Asn Met Met Ser Asp Gly Glu Phe Leu Arg Thr Ser Cys 
        435                 440                 445             


Gly Ser Pro Asn Tyr Ala Ala Pro Glu Val Ile Ser Gly Arg Leu Tyr 
    450                 455                 460                 


Ala Gly Pro Glu Val Asp Ile Trp Ser Cys Gly Val Ile Leu Tyr Ala 
465                 470                 475                 480 


Leu Leu Cys Gly Thr Leu Pro Phe Asp Asp Glu His Val Pro Thr Leu 
                485                 490                 495     


Phe Lys Lys Ile Arg Gly Gly Val Phe Tyr Ile Pro Glu Tyr Leu Asn 
            500                 505                 510         


Arg Ser Ile Ala Thr Leu Leu Met His Met Leu Gln Val Asp Pro Leu 
        515                 520                 525             


Lys Arg Ala Thr Ile Lys Asp Ile Arg Glu His Glu Trp Phe Lys Gln 
    530                 535                 540                 


Asp Leu Pro Ser Tyr Leu Phe Pro Glu Asp Pro Ser Tyr Asp Ala Asn 
545                 550                 555                 560 


Val Ile Asp Asp Glu Ala Val Lys Glu Val Cys Glu Lys Phe Glu Cys 
                565                 570                 575     


Thr Glu Ser Glu Val Met Asn Ser Leu Tyr Ser Gly Asp Pro Gln Asp 
            580                 585                 590         


Gln Leu Ala Val Ala Tyr His Leu Ile Ile Asp Asn Arg Arg Ile Met 
        595                 600                 605             


Asn Gln Ala Ser Glu Phe Tyr Leu Ala Ser Ser Pro Pro Thr Gly Ser 
    610                 615                 620                 


Phe Met Asp Asp Met Ala Met His Ile Pro Pro Gly Leu Lys Pro His 
625                 630                 635                 640 


Pro Glu Arg Met Pro Pro Leu Ile Ala Asp Ser Pro Lys Ala Arg Cys 
                645                 650                 655     


Pro Leu Asp Ala Leu Asn Thr Thr Lys Pro Lys Ser Leu Ala Val Lys 
            660                 665                 670         


Lys Ala Lys Trp His Leu Gly Ile Arg Ser Gln Ser Lys Pro Tyr Asp 
        675                 680                 685             


Ile Met Ala Glu Val Tyr Arg Ala Met Lys Gln Leu Asp Phe Glu Trp 
    690                 695                 700                 


Lys Val Val Asn Ala Tyr His Leu Arg Val Arg Arg Lys Asn Pro Val 
705                 710                 715                 720 


Thr Gly Asn Tyr Val Lys Met Ser Leu Gln Leu Tyr Leu Val Asp Asn 
                725                 730                 735     


Arg Ser Tyr Leu Leu Asp Phe Lys Ser Ile Asp Asp Glu Val Val Glu 
            740                 745                 750         


Gln Arg Ser Gly Ser Ser Thr Pro Gln Arg Ser Cys Ser Ala Ala Gly 
        755                 760                 765             


Leu His Arg Pro Arg Ser Ser Val Asp Ser Ser Thr Ala Glu Asn His 
    770                 775                 780                 


Ser Leu Ser Gly Ser Leu Thr Gly Ser Leu Thr Gly Ser Thr Leu Ser 
785                 790                 795                 800 


Ser Ala Ser Pro Arg Leu Gly Ser His Thr Met Asp Phe Phe Glu Met 
                805                 810                 815     


Cys Ala Ser Leu Ile Thr Ala Leu Ala Arg Lys Leu 
            820                 825             


<210>  8
<211>  2710
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human beta2 subunit pACE plasmid

<400>  8
tatcgataat acgactcact ataggggaat tgtgagcgga taacaattcc cctctagaaa       60

taattttgtt taactttaag aaggagatat acatatgagg cctatgggaa acaccaccag      120

cgaccgggtg tccggggagc gccacggcgc caaggctgca cgctccgagg gcgcaggcgg      180

ccatgccccg gggaaggagc acaagatcat ggtggggagt acggacgacc ccagcgtgtt      240

cagcctccct gactccaagc tccctgggga caaagagttt gtatcatggc agcaggattt      300

ggaggactcc gtaaagccca cacagcaggc ccggcccact gttatccgct ggtctgaagg      360

aggcaaggag gtcttcatct ctgggtcttt caacaattgg agcaccaaga ttccactgat      420

taagagccat aatgactttg ttgccatcct ggacctccct gagggagagc accaatacaa      480

gttctttgtg gatggacagt gggttcatga tccatcagag cctgtggtta ccagtcagct      540

tggcacaatt aacaatttga tccatgtcaa gaaatctgat tttgaggtgt tcgatgcttt      600

aaagttagat tctatggaaa gttctgagac atcttgtaga gacctttcca gctcaccccc      660

agggccttat ggtcaagaaa tgtatgcgtt tcgatctgag gaaagattca aatccccacc      720

catccttcct cctcatctac ttcaagttat tcttaacaaa gacactaata tttcttgtga      780

cccagcctta ctccctgagc ccaaccatgt tatgctgaac catctctatg cattgtccat      840

taaggacagt gtgatggtcc ttagcgcaac ccatcgctac aagaagaagt atgttactac      900

tctgctatac aagcccattg tgcactaagc atgctagcat aaccccttgg ggcctctaaa      960

cgggtcttga ggggtttttt ggtttaaacc catgtgcctg gcagataact tcgtataatg     1020

tatgctatac gaagttatgg taccgcggcc gcgtagagga tctgttgatc agcagttcaa     1080

cctgttgata gtacgtacta agctctcatg tttcacgtac taagctctca tgtttaacgt     1140

actaagctct catgtttaac gaactaaacc ctcatggcta acgtactaag ctctcatggc     1200

taacgtacta agctctcatg tttcacgtac taagctctca tgtttgaaca ataaaattaa     1260

tataaatcag caacttaaat agcctctaag gttttaagtt ttataagaaa aaaaagaata     1320

tataaggctt ttaaagcttt taaggtttaa cggttgtgga caacaagcca gggatgtaac     1380

gcactgagaa gcccttagag cctctcaaag caattttgag tgacacagga acacttaacg     1440

gctgacagaa ttagcttcac gctgccgcaa gcactcaggg cgcaagggct gctaaaggaa     1500

gcggaacacg tagaaagcca gtccgcagaa acggtgctga ccccggatga atgtcagctg     1560

ggaggcagaa taaatgatca tatcgtcaat tattacctcc acggggagag cctgagcaaa     1620

ctggcctcag gcatttgaga agcacacggt cacactgctt ccggtagtca ataaaccggt     1680

aaaccagcaa tagacataag cggctattta acgaccctgc cctgaaccga cgaccgggtc     1740

gaatttgctt tcgaatttct gccattcatc cgcttattat cacttattca ggcgtagcaa     1800

ccaggcgttt aagggcacca ataactgcct taaaaaaatt acgccccgcc ctgccactca     1860

tcgcagtact gttgtaattc attaagcatt ctgccgacat ggaagccatc acaaacggca     1920

tgatgaacct gaatcgccag cggcatcagc accttgtcgc cttgcgtata atatttgccc     1980

atggtgaaaa cgggggcgaa gaagttgtcc atattggcca cgtttaaatc aaaactggtg     2040

aaactcaccc agggattggc tgagacgaaa aacatattct caataaaccc tttagggaaa     2100

taggccaggt tttcaccgta acacgccaca tcttgcgaat atatgtgtag aaactgccgg     2160

aaatcgtcgt ggtattcact ccagagcgat gaaaacgttt cagtttgctc atggaaaacg     2220

gtgtaacaag ggtgaacact atcccatatc accagctcac cgtctttcat tgccatacgg     2280

aattccggat gagcattcat caggcgggca agaatgtgaa taaaggccgg ataaaacttg     2340

tgcttatttt tctttacggt ctttaaaaag gccgtaatat ccagctgaac ggtctggtta     2400

taggtacatt gagcaactga ctgaaatgcc tcaaaatgtt ctttacgatg ccattgggat     2460

atatcaacgg tggtatatcc agtgattttt ttctccattt tagcttcctt agctcctgaa     2520

aatctcgata actcaaaaaa tacgcccggt agtgatctta tttcattatg gtgaaagttg     2580

gaccctctta cgtgccgatc aacgtctcat tttcgccaaa agttggccca gatcaacgtc     2640

tcattttcgc caaaagttgg cccagatcta tgtcgggtgc ggagaaagag gtaatgaaat     2700

ggcacctagg                                                            2710


<210>  9
<211>  272
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Met Gly Asn Thr Thr Ser Asp Arg Val Ser Gly Glu Arg His Gly Ala 
1               5                   10                  15      


Lys Ala Ala Arg Ser Glu Gly Ala Gly Gly His Ala Pro Gly Lys Glu 
            20                  25                  30          


His Lys Ile Met Val Gly Ser Thr Asp Asp Pro Ser Val Phe Ser Leu 
        35                  40                  45              


Pro Asp Ser Lys Leu Pro Gly Asp Lys Glu Phe Val Ser Trp Gln Gln 
    50                  55                  60                  


Asp Leu Glu Asp Ser Val Lys Pro Thr Gln Gln Ala Arg Pro Thr Val 
65                  70                  75                  80  


Ile Arg Trp Ser Glu Gly Gly Lys Glu Val Phe Ile Ser Gly Ser Phe 
                85                  90                  95      


Asn Asn Trp Ser Thr Lys Ile Pro Leu Ile Lys Ser His Asn Asp Phe 
            100                 105                 110         


Val Ala Ile Leu Asp Leu Pro Glu Gly Glu His Gln Tyr Lys Phe Phe 
        115                 120                 125             


Val Asp Gly Gln Trp Val His Asp Pro Ser Glu Pro Val Val Thr Ser 
    130                 135                 140                 


Gln Leu Gly Thr Ile Asn Asn Leu Ile His Val Lys Lys Ser Asp Phe 
145                 150                 155                 160 


Glu Val Phe Asp Ala Leu Lys Leu Asp Ser Met Glu Ser Ser Glu Thr 
                165                 170                 175     


Ser Cys Arg Asp Leu Ser Ser Ser Pro Pro Gly Pro Tyr Gly Gln Glu 
            180                 185                 190         


Met Tyr Ala Phe Arg Ser Glu Glu Arg Phe Lys Ser Pro Pro Ile Leu 
        195                 200                 205             


Pro Pro His Leu Leu Gln Val Ile Leu Asn Lys Asp Thr Asn Ile Ser 
    210                 215                 220                 


Cys Asp Pro Ala Leu Leu Pro Glu Pro Asn His Val Met Leu Asn His 
225                 230                 235                 240 


Leu Tyr Ala Leu Ser Ile Lys Asp Ser Val Met Val Leu Ser Ala Thr 
                245                 250                 255     


His Arg Tyr Lys Lys Lys Tyr Val Thr Thr Leu Leu Tyr Lys Pro Ile 
            260                 265                 270         


<210>  10
<211>  3508
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human beta2-YFP pDC plasmid

<400>  10
cgccccgccc tgccactcat cgcagtactg ttgtaattca ttaagcattc tgccgacatg       60

gaagccatca caaacggcat gatgaacctg aatcgccagc ggcatcagca ccttgtcgcc      120

ttgcgtataa tatttgccca tggtgaaaac gggggcgaag aagttgtcca tattggccac      180

gtttaaatca aaactggtga aactcaccca gggattggct gagacgaaaa acatattctc      240

aataaaccct ttagggaaat aggccaggtt ttcaccgtaa cacgccacat cttgcgaata      300

tatgtgtaga aactgccgga aatcgtcgtg gtattcactc cagagcgatg aaaacgtttc      360

agtttgctca tggaaaacgg tgtaacaagg gtgaacacta tcccatatca ccagctcacc      420

gtctttcatt gccatacgga attccggatg agcattcatc aggcgggcaa gaatgtgaat      480

aaaggccgga taaaacttgt gcttattttt ctttacggtc tttaaaaagg ccgtaatatc      540

cagctgaacg gtctggttat aggtacattg agcaactgac tgaaatgcct caaaatgttc      600

tttacgatgc cattgggata tatcaacggt ggtatatcca gtgatttttt tctccatttt      660

agcttcctta gctcctgaaa atctcgataa ctcaaaaaat acgcccggta gtgatcttat      720

ttcattatgg tgaaagttgg accctcttac gtgccgatca acgtctcatt ttcgccaaaa      780

gttggcccag atcaacgtct cattttcgcc aaaagttggc ccagatctat gtcgggtgcg      840

gagaaagagg taatgaaatg gcacctaggt atcgataata cgactcacta taggggaatt      900

gtgagcggat aacaattccc ctctagaaat aattttgttt aactttaaga aggagatata      960

catatgaggc ctatgggaaa caccaccagc gaccgggtgt ccggggagcg ccacggcgcc     1020

aaggctgcac gctccgaggg cgcaggcggc catgccccgg ggaaggagca caagatcatg     1080

gtggggagta cggacgaccc cagcgtgttc agcctccctg actccaagct ccctggggac     1140

aaagagtttg tatcatggca gcaggatttg gaggactccg taaagcccac acagcaggcc     1200

cggcccactg ttatccgctg gtctgaagga ggcaaggagg tcttcatctc tgggtctttc     1260

aacaattgga gcaccaagat tccactgatt aagagccata atgactttgt tgccatcctg     1320

gacctccctg agggagagca ccaatacaag ttctttgtgg atggacagtg ggttcatgat     1380

ccatcagagc ctgtggttac cagtcagctt ggcacaatta acaatttgat ccatgtcaag     1440

aaatctgatt ttgaggtgtt cgatgcttta aagttagatt ctatggaaag ttctgagaca     1500

tcttgtagag acctttccag ctcaccccca gggccttatg gtcaagaaat gtatgcgttt     1560

cgatctgagg aaagattcaa atccccaccc atccttcctc ctcatctact tcaagttatt     1620

cttaacaaag acactaatat ttcttgtgac ccagccttac tccctgagcc caaccatgtt     1680

atgctgaacc atctctatgc attgtccatt aaggacagtg tgatggtcct tagcgcaacc     1740

catcgctaca agaagaagta tgttactact ctgctataca agcccattgt gcacatggtg     1800

agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac     1860

gtaaacggcc acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag     1920

ctgaccctga agttcatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg     1980

accaccttcg gctacggcct gcagtgcttc gcccgctacc ccgaccacat gaagcagcac     2040

gacttcttca agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag     2100

gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac     2160

cgcatcgagc tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg     2220

gagtacaact acaacagcca caacgtctat atcatggccg acaagcagaa gaacggcatc     2280

aaggtgaact tcaagatccg ccacaacatc gaggacggca gcgtgcagct cgccgaccac     2340

taccagcaga acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg     2400

agctaccagt ccgccctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg     2460

gagttcgtga ccgccgccgg gatcactctc ggcatggacg agctgtacaa gtccggactc     2520

agatctcgag ctcaagcttc gaattctgca gtcgacggta ccgcgggccc gggatccacc     2580

ggatctagat gataagcatg ctagcataac cccttggggc ctctaaacgg gtcttgaggg     2640

gttttttggt ttaaacccat gtgcctggca gataacttcg tataatgtat gctatacgaa     2700

gttatggtac cgcggccgcg tagaggatct gttgatcagc agttcaacct gttgatagta     2760

cgtactaagc tctcatgttt cacgtactaa gctctcatgt ttaacgtact aagctctcat     2820

gtttaacgaa ctaaaccctc atggctaacg tactaagctc tcatggctaa cgtactaagc     2880

tctcatgttt cacgtactaa gctctcatgt ttgaacaata aaattaatat aaatcagcaa     2940

cttaaatagc ctctaaggtt ttaagtttta taagaaaaaa aagaatatat aaggctttta     3000

aagcttttaa ggtttaacgg ttgtggacaa caagccaggg atgtaacgca ctgagaagcc     3060

cttagagcct ctcaaagcaa ttttgagtga cacaggaaca cttaacggct gacagaatta     3120

gcttcacgct gccgcaagca ctcagggcgc aagggctgct aaaggaagcg gaacacgtag     3180

aaagccagtc cgcagaaacg gtgctgaccc cggatgaatg tcagctggga ggcagaataa     3240

atgatcatat cgtcaattat tacctccacg gggagagcct gagcaaactg gcctcaggca     3300

tttgagaagc acacggtcac actgcttccg gtagtcaata aaccggtaaa ccagcaatag     3360

acataagcgg ctatttaacg accctgccct gaaccgacga ccgggtcgaa tttgctttcg     3420

aatttctgcc attcatccgc ttattatcac ttattcaggc gtagcaacca ggcgtttaag     3480

ggcaccaata actgccttaa aaaaatta                                        3508


<210>  11
<211>  539
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human beta2-YFP

<400>  11

Met Gly Asn Thr Thr Ser Asp Arg Val Ser Gly Glu Arg His Gly Ala 
1               5                   10                  15      


Lys Ala Ala Arg Ser Glu Gly Ala Gly Gly His Ala Pro Gly Lys Glu 
            20                  25                  30          


His Lys Ile Met Val Gly Ser Thr Asp Asp Pro Ser Val Phe Ser Leu 
        35                  40                  45              


Pro Asp Ser Lys Leu Pro Gly Asp Lys Glu Phe Val Ser Trp Gln Gln 
    50                  55                  60                  


Asp Leu Glu Asp Ser Val Lys Pro Thr Gln Gln Ala Arg Pro Thr Val 
65                  70                  75                  80  


Ile Arg Trp Ser Glu Gly Gly Lys Glu Val Phe Ile Ser Gly Ser Phe 
                85                  90                  95      


Asn Asn Trp Ser Thr Lys Ile Pro Leu Ile Lys Ser His Asn Asp Phe 
            100                 105                 110         


Val Ala Ile Leu Asp Leu Pro Glu Gly Glu His Gln Tyr Lys Phe Phe 
        115                 120                 125             


Val Asp Gly Gln Trp Val His Asp Pro Ser Glu Pro Val Val Thr Ser 
    130                 135                 140                 


Gln Leu Gly Thr Ile Asn Asn Leu Ile His Val Lys Lys Ser Asp Phe 
145                 150                 155                 160 


Glu Val Phe Asp Ala Leu Lys Leu Asp Ser Met Glu Ser Ser Glu Thr 
                165                 170                 175     


Ser Cys Arg Asp Leu Ser Ser Ser Pro Pro Gly Pro Tyr Gly Gln Glu 
            180                 185                 190         


Met Tyr Ala Phe Arg Ser Glu Glu Arg Phe Lys Ser Pro Pro Ile Leu 
        195                 200                 205             


Pro Pro His Leu Leu Gln Val Ile Leu Asn Lys Asp Thr Asn Ile Ser 
    210                 215                 220                 


Cys Asp Pro Ala Leu Leu Pro Glu Pro Asn His Val Met Leu Asn His 
225                 230                 235                 240 


Leu Tyr Ala Leu Ser Ile Lys Asp Ser Val Met Val Leu Ser Ala Thr 
                245                 250                 255     


His Arg Tyr Lys Lys Lys Tyr Val Thr Thr Leu Leu Tyr Lys Pro Ile 
            260                 265                 270         


Val His Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
        275                 280                 285             


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
    290                 295                 300                 


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
305                 310                 315                 320 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
                325                 330                 335     


Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His 
            340                 345                 350         


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
        355                 360                 365             


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
    370                 375                 380                 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
385                 390                 395                 400 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
                405                 410                 415     


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
            420                 425                 430         


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
        435                 440                 445             


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
    450                 455                 460                 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser 
465                 470                 475                 480 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
                485                 490                 495     


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
            500                 505                 510         


Lys Ser Gly Leu Arg Ser Arg Ala Gln Ala Ser Asn Ser Ala Val Asp 
        515                 520                 525             


Gly Thr Ala Gly Pro Gly Ser Thr Gly Ser Arg 
    530                 535                 


<210>  12
<211>  3502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human YFP-beta2

<400>  12
cgccccgccc tgccactcat cgcagtactg ttgtaattca ttaagcattc tgccgacatg       60

gaagccatca caaacggcat gatgaacctg aatcgccagc ggcatcagca ccttgtcgcc      120

ttgcgtataa tatttgccca tggtgaaaac gggggcgaag aagttgtcca tattggccac      180

gtttaaatca aaactggtga aactcaccca gggattggct gagacgaaaa acatattctc      240

aataaaccct ttagggaaat aggccaggtt ttcaccgtaa cacgccacat cttgcgaata      300

tatgtgtaga aactgccgga aatcgtcgtg gtattcactc cagagcgatg aaaacgtttc      360

agtttgctca tggaaaacgg tgtaacaagg gtgaacacta tcccatatca ccagctcacc      420

gtctttcatt gccatacgga attccggatg agcattcatc aggcgggcaa gaatgtgaat      480

aaaggccgga taaaacttgt gcttattttt ctttacggtc tttaaaaagg ccgtaatatc      540

cagctgaacg gtctggttat aggtacattg agcaactgac tgaaatgcct caaaatgttc      600

tttacgatgc cattgggata tatcaacggt ggtatatcca gtgatttttt tctccatttt      660

agcttcctta gctcctgaaa atctcgataa ctcaaaaaat acgcccggta gtgatcttat      720

ttcattatgg tgaaagttgg accctcttac gtgccgatca acgtctcatt ttcgccaaaa      780

gttggcccag atcaacgtct cattttcgcc aaaagttggc ccagatctat gtcgggtgcg      840

gagaaagagg taatgaaatg gcacctaggt atcgataata cgactcacta taggggaatt      900

gtgagcggat aacaattccc ctctagaaat aattttgttt aactttaaga aggagatata      960

catatggtga gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg     1020

gacggcgacg taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc     1080

tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc     1140

accctcgtga ccaccttcgg ctacggcctg cagtgcttcg cccgctaccc cgaccacatg     1200

aagcagcacg acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc     1260

ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc     1320

ctggtgaacc gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg     1380

cacaagctgg agtacaacta caacagccac aacgtctata tcatggccga caagcagaag     1440

aacggcatca aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc     1500

gccgaccact accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac     1560

cactacctga gctaccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg     1620

gtcctgctgg agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag     1680

tccggactca gatctcgagc tcaagcttcg aattctgcag tcgacggtac cgcgggcccg     1740

ggatccaccg gatctagaag gcctatggga aacaccacca gcgaccgggt gtccggggag     1800

cgccacggcg ccaaggctgc acgctccgag ggcgcaggcg gccatgcccc ggggaaggag     1860

cacaagatca tggtggggag tacggacgac cccagcgtgt tcagcctccc tgactccaag     1920

ctccctgggg acaaagagtt tgtatcatgg cagcaggatt tggaggactc cgtaaagccc     1980

acacagcagg cccggcccac tgttatccgc tggtctgaag gaggcaagga ggtcttcatc     2040

tctgggtctt tcaacaattg gagcaccaag attccactga ttaagagcca taatgacttt     2100

gttgccatcc tggacctccc tgagggagag caccaataca agttctttgt ggatggacag     2160

tgggttcatg atccatcaga gcctgtggtt accagtcagc ttggcacaat taacaatttg     2220

atccatgtca agaaatctga ttttgaggtg ttcgatgctt taaagttaga ttctatggaa     2280

agttctgaga catcttgtag agacctttcc agctcacccc cagggcctta tggtcaagaa     2340

atgtatgcgt ttcgatctga ggaaagattc aaatccccac ccatccttcc tcctcatcta     2400

cttcaagtta ttcttaacaa agacactaat atttcttgtg acccagcctt actccctgag     2460

cccaaccatg ttatgctgaa ccatctctat gcattgtcca ttaaggacag tgtgatggtc     2520

cttagcgcaa cccatcgcta caagaagaag tatgttacta ctctgctata caagcccatt     2580

gtgcactaag catgctagca taaccccttg gggcctctaa acgggtcttg aggggttttt     2640

tggtttaaac ccatgtgcct ggcagataac ttcgtataat gtatgctata cgaagttatg     2700

gtaccgcggc cgcgtagagg atctgttgat cagcagttca acctgttgat agtacgtact     2760

aagctctcat gtttcacgta ctaagctctc atgtttaacg tactaagctc tcatgtttaa     2820

cgaactaaac cctcatggct aacgtactaa gctctcatgg ctaacgtact aagctctcat     2880

gtttcacgta ctaagctctc atgtttgaac aataaaatta atataaatca gcaacttaaa     2940

tagcctctaa ggttttaagt tttataagaa aaaaaagaat atataaggct tttaaagctt     3000

ttaaggttta acggttgtgg acaacaagcc agggatgtaa cgcactgaga agcccttaga     3060

gcctctcaaa gcaattttga gtgacacagg aacacttaac ggctgacaga attagcttca     3120

cgctgccgca agcactcagg gcgcaagggc tgctaaagga agcggaacac gtagaaagcc     3180

agtccgcaga aacggtgctg accccggatg aatgtcagct gggaggcaga ataaatgatc     3240

atatcgtcaa ttattacctc cacggggaga gcctgagcaa actggcctca ggcatttgag     3300

aagcacacgg tcacactgct tccggtagtc aataaaccgg taaaccagca atagacataa     3360

gcggctattt aacgaccctg ccctgaaccg acgaccgggt cgaatttgct ttcgaatttc     3420

tgccattcat ccgcttatta tcacttattc aggcgtagca accaggcgtt taagggcacc     3480

aataactgcc ttaaaaaaat ta                                              3502


<210>  13
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human YFP-b2

<400>  13

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser 
225                 230                 235                 240 


Gly Leu Arg Ser Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr 
                245                 250                 255     


Ala Gly Pro Gly Ser Thr Gly Ser Arg Arg Pro Met Gly Asn Thr Thr 
            260                 265                 270         


Ser Asp Arg Val Ser Gly Glu Arg His Gly Ala Lys Ala Ala Arg Ser 
        275                 280                 285             


Glu Gly Ala Gly Gly His Ala Pro Gly Lys Glu His Lys Ile Met Val 
    290                 295                 300                 


Gly Ser Thr Asp Asp Pro Ser Val Phe Ser Leu Pro Asp Ser Lys Leu 
305                 310                 315                 320 


Pro Gly Asp Lys Glu Phe Val Ser Trp Gln Gln Asp Leu Glu Asp Ser 
                325                 330                 335     


Val Lys Pro Thr Gln Gln Ala Arg Pro Thr Val Ile Arg Trp Ser Glu 
            340                 345                 350         


Gly Gly Lys Glu Val Phe Ile Ser Gly Ser Phe Asn Asn Trp Ser Thr 
        355                 360                 365             


Lys Ile Pro Leu Ile Lys Ser His Asn Asp Phe Val Ala Ile Leu Asp 
    370                 375                 380                 


Leu Pro Glu Gly Glu His Gln Tyr Lys Phe Phe Val Asp Gly Gln Trp 
385                 390                 395                 400 


Val His Asp Pro Ser Glu Pro Val Val Thr Ser Gln Leu Gly Thr Ile 
                405                 410                 415     


Asn Asn Leu Ile His Val Lys Lys Ser Asp Phe Glu Val Phe Asp Ala 
            420                 425                 430         


Leu Lys Leu Asp Ser Met Glu Ser Ser Glu Thr Ser Cys Arg Asp Leu 
        435                 440                 445             


Ser Ser Ser Pro Pro Gly Pro Tyr Gly Gln Glu Met Tyr Ala Phe Arg 
    450                 455                 460                 


Ser Glu Glu Arg Phe Lys Ser Pro Pro Ile Leu Pro Pro His Leu Leu 
465                 470                 475                 480 


Gln Val Ile Leu Asn Lys Asp Thr Asn Ile Ser Cys Asp Pro Ala Leu 
                485                 490                 495     


Leu Pro Glu Pro Asn His Val Met Leu Asn His Leu Tyr Ala Leu Ser 
            500                 505                 510         


Ile Lys Asp Ser Val Met Val Leu Ser Ala Thr His Arg Tyr Lys Lys 
        515                 520                 525             


Lys Tyr Val Thr Thr Leu Leu Tyr Lys Pro Ile 
    530                 535                 


<210>  14
<211>  2890
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1, pDS plasmid

<400>  14
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga tggctttaca ctttatgctt ccggctcgta      900

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt      960

acgaatttct agaaataatt ttgtttaact ttaagaagga gatatacata tggagtcggt     1020

tgctgcagag agcgctccag ctccggagaa tgaacactct caagagaccc cggaatcgaa     1080

cagtagtgtg tacaccacct tcatgaagtc tcatcgctgc tatgacctga tccccacaag     1140

ctccaagctg gtggtatttg atacttcgct gcaggtaaag aaagccttct ttgccctggt     1200

gactaacggt gttcgtgctg cccctttgtg ggatagtaag aagcagagct ttgtgggcat     1260

gctgaccatc actgacttca tcaatattct gcaccgatac tacaagtcag ccctggtgca     1320

gatctatgaa ctggaggagc acaagataga gacttggaga gaggtctacc tgcaagactc     1380

ctttaagcca cttgtctgca tttctccaaa tgccagcttg ttcgatgctg tctcttcatt     1440

aattcgaaat aagatccaca ggcttccagt tattgacccg gagtcaggca acaccttgta     1500

cattcttact cacaagcgga tcctcaagtt cctcaagttg tttatcactg agttccccaa     1560

gccggaattc atgtctaagt ctctggaaga gctacagatt ggcacctacg ccaatattgc     1620

catggtccgt accactacac ctgtctatgt ggctctgggc atctttgtac agcaccgagt     1680

ctccgccttg cctgtggtgg atgagaaagg gcgtgtggtg gacatctact ccaagtttga     1740

tgtgattaat ttggcagcag aaaagacata caacaaccta gatgtgtctg tgacaaaagc     1800

cctacagcac cggtcacact acttcgaggg tgttctcaag tgctacctac atgagactct     1860

agaagcaatc atcaatagac tggtggaagc agaggttcac cgtctggtgg tggtggatga     1920

acatgacgtg gtcaagggca ttgtatcgct gtctgacatc ttacaggctc tggtgctcac     1980

aggtggagag aagaagccct gataactagt tccgtttaaa cccatgtgcc tggcagataa     2040

cttcgtataa tgtatgctat acgaagttat ggtacgtact aagctctcat gtttcacgta     2100

ctaagctctc atgtttaacg tactaagctc tcatgtttaa cgaactaaac cctcatggct     2160

aacgtactaa gctctcatgg ctaacgtact aagctctcat gtttcacgta ctaagctctc     2220

atgtttgaac aataaaatta atataaatca gcaacttaaa tagcctctaa ggttttaagt     2280

tttataagaa aaaaaagaat atataaggct tttaaagctt ttaaggttta acggttgtgg     2340

acaacaagcc agggatgtaa cgcactgaga agcccttaga gcctctcaaa gcaattttga     2400

gtgacacagg aacacttaac ggctgacata attcagcttc acgctgccgc aagcactcag     2460

ggcgcaaggg ctgctaaagg aagcggaaca cgtagaaagc cagtccgcag aaacggtgct     2520

gaccccggat gaatgtcagc tgggaggcag aataaatgat catatcgtca attattacct     2580

ccacggggag agcctgagca aactggcctc aggcatttga gaagcacacg gtcacactgc     2640

ttccggtagt caataaaccg gtaagtagcg tatgcgctca cgcaactggt ccagaacctt     2700

gaccgaacgc agcggtggta acggcgcagt ggcggttttc atggcttgtt atgactgttt     2760

ttttggggta cagtctatgc ctcgggcatc caagcagcaa gcgcgttacg ccgtgggtcg     2820

atgtttgatg ttatggagca gcaacgatgt tacgcagcag ggcagtcgcc ctaaaacaaa     2880

gttaaacatc                                                            2890


<210>  15
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  15

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro 
                325                 330 


<210>  16
<211>  3640
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-eCFP, pDS plasmid

<400>  16
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga tggctttaca ctttatgctt ccggctcgta      900

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt      960

acgaatttct agaaataatt ttgtttaact ttaagaagga gatatacata tggagtcggt     1020

tgctgcagag agcgctccag ctccggagaa tgaacactct caagagaccc cggaatcgaa     1080

cagtagtgtg tacaccacct tcatgaagtc tcatcgctgc tatgacctga tccccacaag     1140

ctccaagctg gtggtatttg atacttcgct gcaggtaaag aaagccttct ttgccctggt     1200

gactaacggt gttcgtgctg cccctttgtg ggatagtaag aagcagagct ttgtgggcat     1260

gctgaccatc actgacttca tcaatattct gcaccgatac tacaagtcag ccctggtgca     1320

gatctatgaa ctggaggagc acaagataga gacttggaga gaggtctacc tgcaagactc     1380

ctttaagcca cttgtctgca tttctccaaa tgccagcttg ttcgatgctg tctcttcatt     1440

aattcgaaat aagatccaca ggcttccagt tattgacccg gagtcaggca acaccttgta     1500

cattcttact cacaagcgga tcctcaagtt cctcaagttg tttatcactg agttccccaa     1560

gccggaattc atgtctaagt ctctggaaga gctacagatt ggcacctacg ccaatattgc     1620

catggtccgt accactacac ctgtctatgt ggctctgggc atctttgtac agcaccgagt     1680

ctccgccttg cctgtggtgg atgagaaagg gcgtgtggtg gacatctact ccaagtttga     1740

tgtgattaat ttggcagcag aaaagacata caacaaccta gatgtgtctg tgacaaaagc     1800

cctacagcac cggtcacact acttcgaggg tgttctcaag tgctacctac atgagactct     1860

agaagcaatc atcaatagac tggtggaagc agaggttcac cgtctggtgg tggtggatga     1920

acatgacgtg gtcaagggca ttgtatcgct gtctgacatc ttacaggctc tggtgctcac     1980

aggtggagag aagaagcccg ctagcatggt gagcaagggc gaggagctgt tcaccggggt     2040

ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc cacaagttca gcgtgtccgg     2100

cgagggcgag ggcgatgcca cctacggcaa gctgaccctg aagttcatct gcaccaccgg     2160

caagctgccc gtgccctggc ccaccctcgt gaccaccctg acctggggcg tgcagtgctt     2220

cagccgctac cccgaccaca tgaagcagca cgacttcttc aagtccgcca tgcccgaagg     2280

ctacgtccag gagcgcacca tcttcttcaa ggacgacggc aactacaaga cccgcgccga     2340

ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca tcgacttcaa     2400

ggaggacggc aacatcctgg ggcacaagct ggagtacaac tacatcagcc acaacgtcta     2460

tatcaccgcc gacaagcaga agaacggcat caaggccaac ttcaagatcc gccacaacat     2520

cgaggacggc agcgtgcagc tcgccgacca ctaccagcag aacaccccca tcggcgacgg     2580

ccccgtgctg ctgcccgaca accactacct gagcacccag tccgccctga gcaaagaccc     2640

caacgagaag cgcgatcaca tggtcctgct ggagttcgtg accgccgccg ggatcactct     2700

cggcatggac gagctgtaca agtccggact cagatctcga cgagctcact gataactagt     2760

tccgtttaaa cccatgtgcc tggcagataa cttcgtataa tgtatgctat acgaagttat     2820

ggtacgtact aagctctcat gtttcacgta ctaagctctc atgtttaacg tactaagctc     2880

tcatgtttaa cgaactaaac cctcatggct aacgtactaa gctctcatgg ctaacgtact     2940

aagctctcat gtttcacgta ctaagctctc atgtttgaac aataaaatta atataaatca     3000

gcaacttaaa tagcctctaa ggttttaagt tttataagaa aaaaaagaat atataaggct     3060

tttaaagctt ttaaggttta acggttgtgg acaacaagcc agggatgtaa cgcactgaga     3120

agcccttaga gcctctcaaa gcaattttga gtgacacagg aacacttaac ggctgacata     3180

attcagcttc acgctgccgc aagcactcag ggcgcaaggg ctgctaaagg aagcggaaca     3240

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tgggaggcag     3300

aataaatgat catatcgtca attattacct ccacggggag agcctgagca aactggcctc     3360

aggcatttga gaagcacacg gtcacactgc ttccggtagt caataaaccg gtaagtagcg     3420

tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta acggcgcagt     3480

ggcggttttc atggcttgtt atgactgttt ttttggggta cagtctatgc ctcgggcatc     3540

caagcagcaa gcgcgttacg ccgtgggtcg atgtttgatg ttatggagca gcaacgatgt     3600

tacgcagcag ggcagtcgcc ctaaaacaaa gttaaacatc                           3640


<210>  17
<211>  580
<212>  PRT
<213>  Homo Sapiens

<400>  17

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro Ala Ser Met Val Ser Lys 
                325                 330                 335     


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
            340                 345                 350         


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
        355                 360                 365             


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
    370                 375                 380                 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Trp Gly 
385                 390                 395                 400 


Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
                405                 410                 415     


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
            420                 425                 430         


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
        435                 440                 445             


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
    450                 455                 460                 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Ile Ser 
465                 470                 475                 480 


His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
                485                 490                 495     


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
            500                 505                 510         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        515                 520                 525             


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro 
    530                 535                 540                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
545                 550                 555                 560 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser 
                565                 570                 575     


Arg Arg Ala His 
            580 


<210>  18
<211>  3640
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat eCFP-gamma1

<400>  18
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga tggctttaca ctttatgctt ccggctcgta      900

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt      960

acgaatttct agaaataatt ttgtttaact ttaagaagga gatatacata tggtgagcaa     1020

gggcgaggag ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa     1080

cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac     1140

cctgaagttc atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac     1200

cctgacctgg ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt     1260

cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga     1320

cggcaactac aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat     1380

cgagctgaag ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta     1440

caactacatc agccacaacg tctatatcac cgccgacaag cagaagaacg gcatcaaggc     1500

caacttcaag atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca     1560

gcagaacacc cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac     1620

ccagtccgcc ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt     1680

cgtgaccgcc gccgggatca ctctcggcat ggacgagctg tacaagtccg gactcagatc     1740

tcgacgagct cacgctagca tggagtcggt tgctgcagag agcgctccag ctccggagaa     1800

tgaacactct caagagaccc cggaatcgaa cagtagtgtg tacaccacct tcatgaagtc     1860

tcatcgctgc tatgacctga tccccacaag ctccaagctg gtggtatttg atacttcgct     1920

gcaggtaaag aaagccttct ttgccctggt gactaacggt gttcgtgctg cccctttgtg     1980

ggatagtaag aagcagagct ttgtgggcat gctgaccatc actgacttca tcaatattct     2040

gcaccgatac tacaagtcag ccctggtgca gatctatgaa ctggaggagc acaagataga     2100

gacttggaga gaggtctacc tgcaagactc ctttaagcca cttgtctgca tttctccaaa     2160

tgccagcttg ttcgatgctg tctcttcatt aattcgaaat aagatccaca ggcttccagt     2220

tattgacccg gagtcaggca acaccttgta cattcttact cacaagcgga tcctcaagtt     2280

cctcaagttg tttatcactg agttccccaa gccggaattc atgtctaagt ctctggaaga     2340

gctacagatt ggcacctacg ccaatattgc catggtccgt accactacac ctgtctatgt     2400

ggctctgggc atctttgtac agcaccgagt ctccgccttg cctgtggtgg atgagaaagg     2460

gcgtgtggtg gacatctact ccaagtttga tgtgattaat ttggcagcag aaaagacata     2520

caacaaccta gatgtgtctg tgacaaaagc cctacagcac cggtcacact acttcgaggg     2580

tgttctcaag tgctacctac atgagactct agaagcaatc atcaatagac tggtggaagc     2640

agaggttcac cgtctggtgg tggtggatga acatgacgtg gtcaagggca ttgtatcgct     2700

gtctgacatc ttacaggctc tggtgctcac aggtggagag aagaagccct gataactagt     2760

tccgtttaaa cccatgtgcc tggcagataa cttcgtataa tgtatgctat acgaagttat     2820

ggtacgtact aagctctcat gtttcacgta ctaagctctc atgtttaacg tactaagctc     2880

tcatgtttaa cgaactaaac cctcatggct aacgtactaa gctctcatgg ctaacgtact     2940

aagctctcat gtttcacgta ctaagctctc atgtttgaac aataaaatta atataaatca     3000

gcaacttaaa tagcctctaa ggttttaagt tttataagaa aaaaaagaat atataaggct     3060

tttaaagctt ttaaggttta acggttgtgg acaacaagcc agggatgtaa cgcactgaga     3120

agcccttaga gcctctcaaa gcaattttga gtgacacagg aacacttaac ggctgacata     3180

attcagcttc acgctgccgc aagcactcag ggcgcaaggg ctgctaaagg aagcggaaca     3240

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tgggaggcag     3300

aataaatgat catatcgtca attattacct ccacggggag agcctgagca aactggcctc     3360

aggcatttga gaagcacacg gtcacactgc ttccggtagt caataaaccg gtaagtagcg     3420

tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta acggcgcagt     3480

ggcggttttc atggcttgtt atgactgttt ttttggggta cagtctatgc ctcgggcatc     3540

caagcagcaa gcgcgttacg ccgtgggtcg atgtttgatg ttatggagca gcaacgatgt     3600

tacgcagcag ggcagtcgcc ctaaaacaaa gttaaacatc                           3640


<210>  19
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat eCFP-gamma1

<400>  19

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser 
225                 230                 235                 240 


Gly Leu Arg Ser Arg Arg Ala His Ala Ser Met Glu Ser Val Ala Ala 
                245                 250                 255     


Glu Ser Ala Pro Ala Pro Glu Asn Glu His Ser Gln Glu Thr Pro Glu 
            260                 265                 270         


Ser Asn Ser Ser Val Tyr Thr Thr Phe Met Lys Ser His Arg Cys Tyr 
        275                 280                 285             


Asp Leu Ile Pro Thr Ser Ser Lys Leu Val Val Phe Asp Thr Ser Leu 
    290                 295                 300                 


Gln Val Lys Lys Ala Phe Phe Ala Leu Val Thr Asn Gly Val Arg Ala 
305                 310                 315                 320 


Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser Phe Val Gly Met Leu Thr 
                325                 330                 335     


Ile Thr Asp Phe Ile Asn Ile Leu His Arg Tyr Tyr Lys Ser Ala Leu 
            340                 345                 350         


Val Gln Ile Tyr Glu Leu Glu Glu His Lys Ile Glu Thr Trp Arg Glu 
        355                 360                 365             


Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu Val Cys Ile Ser Pro Asn 
    370                 375                 380                 


Ala Ser Leu Phe Asp Ala Val Ser Ser Leu Ile Arg Asn Lys Ile His 
385                 390                 395                 400 


Arg Leu Pro Val Ile Asp Pro Glu Ser Gly Asn Thr Leu Tyr Ile Leu 
                405                 410                 415     


Thr His Lys Arg Ile Leu Lys Phe Leu Lys Leu Phe Ile Thr Glu Phe 
            420                 425                 430         


Pro Lys Pro Glu Phe Met Ser Lys Ser Leu Glu Glu Leu Gln Ile Gly 
        435                 440                 445             


Thr Tyr Ala Asn Ile Ala Met Val Arg Thr Thr Thr Pro Val Tyr Val 
    450                 455                 460                 


Ala Leu Gly Ile Phe Val Gln His Arg Val Ser Ala Leu Pro Val Val 
465                 470                 475                 480 


Asp Glu Lys Gly Arg Val Val Asp Ile Tyr Ser Lys Phe Asp Val Ile 
                485                 490                 495     


Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn Leu Asp Val Ser Val Thr 
            500                 505                 510         


Lys Ala Leu Gln His Arg Ser His Tyr Phe Glu Gly Val Leu Lys Cys 
        515                 520                 525             


Tyr Leu His Glu Thr Leu Glu Ala Ile Ile Asn Arg Leu Val Glu Ala 
    530                 535                 540                 


Glu Val His Arg Leu Val Val Val Asp Glu His Asp Val Val Lys Gly 
545                 550                 555                 560 


Ile Val Ser Leu Ser Asp Ile Leu Gln Ala Leu Val Leu Thr Gly Gly 
                565                 570                 575     


Glu Lys Lys Pro 
            580 


<210>  20
<211>  3691
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-YFP, pDS plasmid

<400>  20
ctatgtcggg tgcggagaaa gaggtaatga aatggcacct aggtatcgat ggctttacac       60

tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga      120

aacagctatg accatgatta cgaatttcta gaaataattt tgtttaactt taagaaggag      180

atatacatat ggagtcggtt gctgcagaga gcgctccagc tccggagaat gaacactctc      240

aagagacccc ggaatcgaac agtagtgtgt acaccacctt catgaagtct catcgctgct      300

atgacctgat ccccacaagc tccaagctgg tggtatttga tacttcgctg caggtaaaga      360

aagccttctt tgccctggtg actaacggtg ttcgtgctgc ccctttgtgg gatagtaaga      420

agcagagctt tgtgggcatg ctgaccatca ctgacttcat caatattctg caccgatact      480

acaagtcagc cctggtgcag atctatgaac tggaggagca caagatagag acttggagag      540

aggtctacct gcaagactcc tttaagccac ttgtctgcat ttctccaaat gccagcttgt      600

tcgatgctgt ctcttcatta attcgaaata agatccacag gcttccagtt attgacccgg      660

agtcaggcaa caccttgtac attcttactc acaagcggat cctcaagttc ctcaagttgt      720

ttatcactga gttccccaag ccggaattca tgtctaagtc tctggaagag ctacagattg      780

gcacctacgc caatattgcc atggtccgta ccactacacc tgtctatgtg gctctgggca      840

tctttgtaca gcaccgagtc tccgccttgc ctgtggtgga tgagaaaggg cgtgtggtgg      900

acatctactc caagtttgat gtgattaatt tggcagcaga aaagacatac aacaacctag      960

atgtgtctgt gacaaaagcc ctacagcacc ggtcacacta cttcgagggt gttctcaagt     1020

gctacctaca tgagactcta gaagcaatca tcaatagact ggtggaagca gaggttcacc     1080

gtctggtggt ggtggatgaa catgacgtgg tcaagggcat tgtatcgctg tctgacatct     1140

tacaggctct ggtgctcaca ggtggagaga agaagcccgc tagcatggtg agcaagggcg     1200

aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc     1260

acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag ctgaccctga     1320

agttcatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg accaccttcg     1380

gctacggcct gcagtgcttc gcccgctacc ccgaccacat gaagcagcac gacttcttca     1440

agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag gacgacggca     1500

actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac cgcatcgagc     1560

tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg gagtacaact     1620

acaacagcca caacgtctat atcatggccg acaagcagaa gaacggcatc aaggtgaact     1680

tcaagatccg ccacaacatc gaggacggca gcgtgcagct cgccgaccac taccagcaga     1740

acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg agctaccagt     1800

ccgccctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg gagttcgtga     1860

ccgccgccgg gatcactctc ggcatggacg agctgtacaa gtccggactc agatctcgag     1920

ctcaagcttc gaattctgca gtcgacggta ccgcgggccc gggatccacc ggatctagat     1980

gataactagt tccgtttaaa cccatgtgcc tggcagataa cttcgtataa tgtatgctat     2040

acgaagttat ggtacgtact aagctctcat gtttcacgta ctaagctctc atgtttaacg     2100

tactaagctc tcatgtttaa cgaactaaac cctcatggct aacgtactaa gctctcatgg     2160

ctaacgtact aagctctcat gtttcacgta ctaagctctc atgtttgaac aataaaatta     2220

atataaatca gcaacttaaa tagcctctaa ggttttaagt tttataagaa aaaaaagaat     2280

atataaggct tttaaagctt ttaaggttta acggttgtgg acaacaagcc agggatgtaa     2340

cgcactgaga agcccttaga gcctctcaaa gcaattttga gtgacacagg aacacttaac     2400

ggctgacata attcagcttc acgctgccgc aagcactcag ggcgcaaggg ctgctaaagg     2460

aagcggaaca cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc     2520

tgggaggcag aataaatgat catatcgtca attattacct ccacggggag agcctgagca     2580

aactggcctc aggcatttga gaagcacacg gtcacactgc ttccggtagt caataaaccg     2640

gtaagtagcg tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta     2700

acggcgcagt ggcggttttc atggcttgtt atgactgttt ttttggggta cagtctatgc     2760

ctcgggcatc caagcagcaa gcgcgttacg ccgtgggtcg atgtttgatg ttatggagca     2820

gcaacgatgt tacgcagcag ggcagtcgcc ctaaaacaaa gttaaacatc atgagggaag     2880

cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc gagcgccatc     2940

tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc ggcctgaagc     3000

cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa acaacgcggc     3060

gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc gagattctcc     3120

gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt tatccagcta     3180

agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt atcttcgagc     3240

cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa catagcgttg     3300

ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag gatctatttg     3360

aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct ggcgatgagc     3420

gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc aaaatcgcgc     3480

cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat cagcccgtca     3540

tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc tcgcgcgcag     3600

atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta gtcggcaaat     3660

aatgtctaac aattcgttca agccgacgga t                                    3691


<210>  21
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-YFP

<400>  21

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro Ala Ser Met Val Ser Lys 
                325                 330                 335     


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
            340                 345                 350         


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
        355                 360                 365             


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
    370                 375                 380                 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly 
385                 390                 395                 400 


Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
                405                 410                 415     


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
            420                 425                 430         


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
        435                 440                 445             


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
    450                 455                 460                 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser 
465                 470                 475                 480 


His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val 
                485                 490                 495     


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
            500                 505                 510         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        515                 520                 525             


Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro 
    530                 535                 540                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
545                 550                 555                 560 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser 
                565                 570                 575     


Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr Ala Gly Pro Gly 
            580                 585                 590         


Ser Thr Gly Ser Arg 
        595         


<210>  22
<211>  3691
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat YFP-gamma1, pDS plasmid

<400>  22
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga tggctttaca ctttatgctt ccggctcgta      900

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt      960

acgaatttct agaaataatt ttgtttaact ttaagaagga gatatacata tggtgagcaa     1020

gggcgaggag ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa     1080

cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac     1140

cctgaagttc atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac     1200

cttcggctac ggcctgcagt gcttcgcccg ctaccccgac cacatgaagc agcacgactt     1260

cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga     1320

cggcaactac aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat     1380

cgagctgaag ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta     1440

caactacaac agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt     1500

gaacttcaag atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca     1560

gcagaacacc cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcta     1620

ccagtccgcc ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt     1680

cgtgaccgcc gccgggatca ctctcggcat ggacgagctg tacaagtccg gactcagatc     1740

tcgagctcaa gcttcgaatt ctgcagtcga cggtaccgcg ggcccgggat ccaccggatc     1800

tagagctagc atggagtcgg ttgctgcaga gagcgctcca gctccggaga atgaacactc     1860

tcaagagacc ccggaatcga acagtagtgt gtacaccacc ttcatgaagt ctcatcgctg     1920

ctatgacctg atccccacaa gctccaagct ggtggtattt gatacttcgc tgcaggtaaa     1980

gaaagccttc tttgccctgg tgactaacgg tgttcgtgct gcccctttgt gggatagtaa     2040

gaagcagagc tttgtgggca tgctgaccat cactgacttc atcaatattc tgcaccgata     2100

ctacaagtca gccctggtgc agatctatga actggaggag cacaagatag agacttggag     2160

agaggtctac ctgcaagact cctttaagcc acttgtctgc atttctccaa atgccagctt     2220

gttcgatgct gtctcttcat taattcgaaa taagatccac aggcttccag ttattgaccc     2280

ggagtcaggc aacaccttgt acattcttac tcacaagcgg atcctcaagt tcctcaagtt     2340

gtttatcact gagttcccca agccggaatt catgtctaag tctctggaag agctacagat     2400

tggcacctac gccaatattg ccatggtccg taccactaca cctgtctatg tggctctggg     2460

catctttgta cagcaccgag tctccgcctt gcctgtggtg gatgagaaag ggcgtgtggt     2520

ggacatctac tccaagtttg atgtgattaa tttggcagca gaaaagacat acaacaacct     2580

agatgtgtct gtgacaaaag ccctacagca ccggtcacac tacttcgagg gtgttctcaa     2640

gtgctaccta catgagactc tagaagcaat catcaataga ctggtggaag cagaggttca     2700

ccgtctggtg gtggtggatg aacatgacgt ggtcaagggc attgtatcgc tgtctgacat     2760

cttacaggct ctggtgctca caggtggaga gaagaagccc tgataactag ttccgtttaa     2820

acccatgtgc ctggcagata acttcgtata atgtatgcta tacgaagtta tggtacgtac     2880

taagctctca tgtttcacgt actaagctct catgtttaac gtactaagct ctcatgttta     2940

acgaactaaa ccctcatggc taacgtacta agctctcatg gctaacgtac taagctctca     3000

tgtttcacgt actaagctct catgtttgaa caataaaatt aatataaatc agcaacttaa     3060

atagcctcta aggttttaag ttttataaga aaaaaaagaa tatataaggc ttttaaagct     3120

tttaaggttt aacggttgtg gacaacaagc cagggatgta acgcactgag aagcccttag     3180

agcctctcaa agcaattttg agtgacacag gaacacttaa cggctgacat aattcagctt     3240

cacgctgccg caagcactca gggcgcaagg gctgctaaag gaagcggaac acgtagaaag     3300

ccagtccgca gaaacggtgc tgaccccgga tgaatgtcag ctgggaggca gaataaatga     3360

tcatatcgtc aattattacc tccacgggga gagcctgagc aaactggcct caggcatttg     3420

agaagcacac ggtcacactg cttccggtag tcaataaacc ggtaagtagc gtatgcgctc     3480

acgcaactgg tccagaacct tgaccgaacg cagcggtggt aacggcgcag tggcggtttt     3540

catggcttgt tatgactgtt tttttggggt acagtctatg cctcgggcat ccaagcagca     3600

agcgcgttac gccgtgggtc gatgtttgat gttatggagc agcaacgatg ttacgcagca     3660

gggcagtcgc cctaaaacaa agttaaacat c                                    3691


<210>  23
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YFP-gamma1

<400>  23

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser 
225                 230                 235                 240 


Gly Leu Arg Ser Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr 
                245                 250                 255     


Ala Gly Pro Gly Ser Thr Gly Ser Arg Ala Ser Met Glu Ser Val Ala 
            260                 265                 270         


Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His Ser Gln Glu Thr Pro 
        275                 280                 285             


Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met Lys Ser His Arg Cys 
    290                 295                 300                 


Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val Val Phe Asp Thr Ser 
305                 310                 315                 320 


Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val Thr Asn Gly Val Arg 
                325                 330                 335     


Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser Phe Val Gly Met Leu 
            340                 345                 350         


Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg Tyr Tyr Lys Ser Ala 
        355                 360                 365             


Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys Ile Glu Thr Trp Arg 
    370                 375                 380                 


Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu Val Cys Ile Ser Pro 
385                 390                 395                 400 


Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu Ile Arg Asn Lys Ile 
                405                 410                 415     


His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly Asn Thr Leu Tyr Ile 
            420                 425                 430         


Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys Leu Phe Ile Thr Glu 
        435                 440                 445             


Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu Glu Glu Leu Gln Ile 
    450                 455                 460                 


Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr Thr Thr Pro Val Tyr 
465                 470                 475                 480 


Val Ala Leu Gly Ile Phe Val Gln His Arg Val Ser Ala Leu Pro Val 
                485                 490                 495     


Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr Ser Lys Phe Asp Val 
            500                 505                 510         


Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn Leu Asp Val Ser Val 
        515                 520                 525             


Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe Glu Gly Val Leu Lys 
    530                 535                 540                 


Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile Asn Arg Leu Val Glu 
545                 550                 555                 560 


Ala Glu Val His Arg Leu Val Val Val Asp Glu His Asp Val Val Lys 
                565                 570                 575     


Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala Leu Val Leu Thr Gly 
            580                 585                 590         


Gly Glu Lys Lys Pro 
        595         


<210>  24
<211>  5007
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat a2-CFP_T172A, pACE plasmid

<400>  24
ggaattccag ataacttcgt ataatgtatg ctatacgaag ttatggtacc gcggccgcgt       60

agaggatctg ttgatcagca gttcaacctg ttgatagtac ttcgttaata cagatgtagg      120

tgttggcacc atgcataact ataacggtcc taaggtagcg acctaggtat cgataatacg      180

actcactata ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa      240

ctttaagaag gagatataat gggcagtagt caccatcacc accaccatca tcaccatcat      300

agtagtgaaa acctgtattt tcaggggcat atggctgaga agcagaagca cgacgggcgt      360

gtgaagatcg gacactacgt gctgggggac accctgggcg tcggcacctt cggcaaagtg      420

aagattggag aacatcaatt gacaggccat aaagtggcag ttaagatctt aaatagacag      480

aagattcgca gtttagatgt tgttggaaaa ataaaacgag aaattcaaaa tcttaaactc      540

tttcgtcatc ctcatattat caaactctac caagtgatca gcactccaac agactttttt      600

atggtaatgg aatatgtgtc tggaggtgaa ttgttcgact acatctgtaa acacgggagg      660

gttgaagagg tggaagctcg ccggctcttc cagcagattc tgtctgccgt ggactactgt      720

cacaggcaca tggttgtcca cagggacctg aagccagaga acgtgttgct ggacgcccag      780

atgaatgcta agatagctga cttcggactc tctaatatga tgtcagatgg tgaatttcta      840

cgagctagct gtggatcgcc aaattatgca gcaccggagg tcatctcagg aaggctgtat      900

gcgggtcctg aggttgatat ctggagctgt ggtgttatcc tgtatgccct tctctgtggc      960

accctcccgt tcgacgatga gcacgtgcct acgctcttta agaagatccg agggggtgtg     1020

ttctacatcc cggagtatct caaccgttct attgccactc tgctgatgca catgctgcag     1080

gtggacccct tgaagcgagc aactatcaaa gacatacgag agcatgaatg gtttaaacag     1140

gatttgccca gttacctctt tcctgaagac ccctcctatg atgctaacgt cattgatgat     1200

gaggctgtga aagaagtatg tgaaaaattt gagtgtacag aatcagaagt gatgaacagt     1260

ttatacagtg gtgaccctca agaccagctc gcagtggctt atcatctcat cattgacaat     1320

cggagaataa tgaaccaagc cagtgagttc tacctcgcct ccagtcctcc aacgggttcc     1380

ttcatggacg atagtgccat gcatattccc cccggcctga aaccacatcc tgaaaggatg     1440

ccacctctca tagcagacag ccccaaagca cgctgtccac tggatgcact caacacaact     1500

aagcccaaat ctttagctgt gaaaaaagcc aagtggcacc ttgggatccg aagccagagc     1560

aaaccatacg acattatggc ggaggtgtac cgagctatga agcagctgga ctttgaatgg     1620

aaggtagtga atgcatacca tcttcgagta agaagaaaaa acccagtgac tggcaattac     1680

gtgaaaatga gcttacagct ttacctggtt gacaatcgga gctatctgct ggactttaaa     1740

agcatcgatg atgaggtggt ggagcagagg tctggttctt caacacctca gcgctcctgt     1800

tctgctgccg gcctccacag acctcggtca agtgtcgatt ccagcacagc cgagaaccat     1860

tcactgtctg gctctctcac tggttctttg actggcagca ctttgtcctc cgcttccccg     1920

cgcctgggca gtcataccat ggattttttt gaaatgtgcg ccagtcttat cactgcttta     1980

gcccgtaagc ttatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg     2040

gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc     2100

gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg     2160

ccctggccca ccctcgtgac caccctgacc tggggcgtgc agtgcttcag ccgctacccc     2220

gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag     2280

cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag     2340

ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac     2400

atcctggggc acaagctgga gtacaactac atcagccaca acgtctatat caccgccgac     2460

aagcagaaga acggcatcaa ggccaacttc aagatccgcc acaacatcga ggacggcagc     2520

gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg     2580

cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc     2640

gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag     2700

ctgtacaagt ccggactcag atctcgacga gctcactgat aactcgagag atccggctgc     2760

taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactagcata     2820

accccttggg gcctctaaac gggtcttgag gggttttttg gtttaaaccc atctaattgg     2880

actagtagcc cgcctaatga gcgggctttt ttttaattcc cctatttgtt tatttttcta     2940

aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata     3000

ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc     3060

ggcattttgc cttcctgttt ttgctcaccc agaaacgctc gtgaaagtaa aagacgcaga     3120

ggaccaattg ggggcacgag tgggatacat agaactggac ttgaatagcg gtaaaatcct     3180

tgagagtttt cgccctgaag agcgttttcc aatgatgagc actttcaaag ttctgctatg     3240

tggagcagta ttatcccgtg tagatgcggg gcaagagcaa ctcggacgac gaatacacta     3300

ttcgcagaat gacttggttg aatactcccc agtgacagaa aagcacctta cggacggaat     3360

gacggtaaga gaattatgta gtgccgccat aacgatgagt gataacactg cggcgaactt     3420

acttctgaca accatcggtg gaccgaagga attaaccgct tttttgcaca atatgggaga     3480

ccatgtaact cgccttgacc gttgggaacc agaactgaat gaagccatac caaacgacga     3540

gcgagacacc acaatgcctg cggcaatggc aacaacatta cgcaaactat taactggcga     3600

actacttact ctggcttcac ggcaacaatt aatagactgg cttgaagcgg ataaagttgc     3660

aggaccacta ctgcgttcgg cacttcctgc tggctggttt attgctgata aatctggggc     3720

aggagagcgt ggttcacggg gtatcattgc cgcacttgga ccagatggta agccttcccg     3780

tatcgtagtt atctacacga cgggtagtca ggcaactatg gacgaacgaa atagacagat     3840

tgctgaaata ggggcttcac tgattaagca ttggtaaacc gatacaatta aaggctcctt     3900

ttggagcctt tttttttgga cggaccggta gaaaagatca aaggatcttc ttgagatcct     3960

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt     4020

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg     4080

cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct     4140

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc     4200

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg     4260

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa     4320

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg     4380

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg     4440

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga     4500

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt     4560

ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct     4620

gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga     4680

acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcctgat gcggtatttt     4740

ctccttacgc atctgtgcgg tatttcacac cgcaatggtg cactctcagt acaatctgct     4800

ctgatgccgc atagttaagc cagtatacac tccgctatcg ctacgtgact gggtcatggc     4860

tgcgccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc     4920

atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc     4980

gtcatcaccg aaacgcgcga ggcaggg                                         5007


<210>  25
<211>  826
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat alpha2-CFP_T172A

<400>  25

Met Gly Ser Ser His His His His His His His His His His Ser Ser 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly His Met Ala Glu Lys Gln Lys His Asp 
            20                  25                  30          


Gly Arg Val Lys Ile Gly His Tyr Val Leu Gly Asp Thr Leu Gly Val 
        35                  40                  45              


Gly Thr Phe Gly Lys Val Lys Ile Gly Glu His Gln Leu Thr Gly His 
    50                  55                  60                  


Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg Ser Leu Asp 
65                  70                  75                  80  


Val Val Gly Lys Ile Lys Arg Glu Ile Gln Asn Leu Lys Leu Phe Arg 
                85                  90                  95      


His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr Pro Thr Asp 
            100                 105                 110         


Phe Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu Phe Asp Tyr 
        115                 120                 125             


Ile Cys Lys His Gly Arg Val Glu Glu Val Glu Ala Arg Arg Leu Phe 
    130                 135                 140                 


Gln Gln Ile Leu Ser Ala Val Asp Tyr Cys His Arg His Met Val Val 
145                 150                 155                 160 


His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala Gln Met Asn 
                165                 170                 175     


Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser Asp Gly Glu 
            180                 185                 190         


Phe Leu Arg Ala Ser Cys Gly Ser Pro Asn Tyr Ala Ala Pro Glu Val 
        195                 200                 205             


Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile Trp Ser Cys 
    210                 215                 220                 


Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro Phe Asp Asp 
225                 230                 235                 240 


Glu His Val Pro Thr Leu Phe Lys Lys Ile Arg Gly Gly Val Phe Tyr 
                245                 250                 255     


Ile Pro Glu Tyr Leu Asn Arg Ser Ile Ala Thr Leu Leu Met His Met 
            260                 265                 270         


Leu Gln Val Asp Pro Leu Lys Arg Ala Thr Ile Lys Asp Ile Arg Glu 
        275                 280                 285             


His Glu Trp Phe Lys Gln Asp Leu Pro Ser Tyr Leu Phe Pro Glu Asp 
    290                 295                 300                 


Pro Ser Tyr Asp Ala Asn Val Ile Asp Asp Glu Ala Val Lys Glu Val 
305                 310                 315                 320 


Cys Glu Lys Phe Glu Cys Thr Glu Ser Glu Val Met Asn Ser Leu Tyr 
                325                 330                 335     


Ser Gly Asp Pro Gln Asp Gln Leu Ala Val Ala Tyr His Leu Ile Ile 
            340                 345                 350         


Asp Asn Arg Arg Ile Met Asn Gln Ala Ser Glu Phe Tyr Leu Ala Ser 
        355                 360                 365             


Ser Pro Pro Thr Gly Ser Phe Met Asp Asp Ser Ala Met His Ile Pro 
    370                 375                 380                 


Pro Gly Leu Lys Pro His Pro Glu Arg Met Pro Pro Leu Ile Ala Asp 
385                 390                 395                 400 


Ser Pro Lys Ala Arg Cys Pro Leu Asp Ala Leu Asn Thr Thr Lys Pro 
                405                 410                 415     


Lys Ser Leu Ala Val Lys Lys Ala Lys Trp His Leu Gly Ile Arg Ser 
            420                 425                 430         


Gln Ser Lys Pro Tyr Asp Ile Met Ala Glu Val Tyr Arg Ala Met Lys 
        435                 440                 445             


Gln Leu Asp Phe Glu Trp Lys Val Val Asn Ala Tyr His Leu Arg Val 
    450                 455                 460                 


Arg Arg Lys Asn Pro Val Thr Gly Asn Tyr Val Lys Met Ser Leu Gln 
465                 470                 475                 480 


Leu Tyr Leu Val Asp Asn Arg Ser Tyr Leu Leu Asp Phe Lys Ser Ile 
                485                 490                 495     


Asp Asp Glu Val Val Glu Gln Arg Ser Gly Ser Ser Thr Pro Gln Arg 
            500                 505                 510         


Ser Cys Ser Ala Ala Gly Leu His Arg Pro Arg Ser Ser Val Asp Ser 
        515                 520                 525             


Ser Thr Ala Glu Asn His Ser Leu Ser Gly Ser Leu Thr Gly Ser Leu 
    530                 535                 540                 


Thr Gly Ser Thr Leu Ser Ser Ala Ser Pro Arg Leu Gly Ser His Thr 
545                 550                 555                 560 


Met Asp Phe Phe Glu Met Cys Ala Ser Leu Ile Thr Ala Leu Ala Arg 
                565                 570                 575     


Lys Leu Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
            580                 585                 590         


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
        595                 600                 605             


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
    610                 615                 620                 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
625                 630                 635                 640 


Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
                645                 650                 655     


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
            660                 665                 670         


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
        675                 680                 685             


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
    690                 695                 700                 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
705                 710                 715                 720 


Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln 
                725                 730                 735     


Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
            740                 745                 750         


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
        755                 760                 765             


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
    770                 775                 780                 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
785                 790                 795                 800 


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
                805                 810                 815     


Lys Ser Gly Leu Arg Ser Arg Arg Ala His 
            820                 825     


<210>  26
<211>  5007
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat alpha2-CFP_T172D, pACE plasmid

<400>  26
ggaattccag ataacttcgt ataatgtatg ctatacgaag ttatggtacc gcggccgcgt       60

agaggatctg ttgatcagca gttcaacctg ttgatagtac ttcgttaata cagatgtagg      120

tgttggcacc atgcataact ataacggtcc taaggtagcg acctaggtat cgataatacg      180

actcactata ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa      240

ctttaagaag gagatataat gggcagtagt caccatcacc accaccatca tcaccatcat      300

agtagtgaaa acctgtattt tcaggggcat atggctgaga agcagaagca cgacgggcgt      360

gtgaagatcg gacactacgt gctgggggac accctgggcg tcggcacctt cggcaaagtg      420

aagattggag aacatcaatt gacaggccat aaagtggcag ttaagatctt aaatagacag      480

aagattcgca gtttagatgt tgttggaaaa ataaaacgag aaattcaaaa tcttaaactc      540

tttcgtcatc ctcatattat caaactctac caagtgatca gcactccaac agactttttt      600

atggtaatgg aatatgtgtc tggaggtgaa ttgttcgact acatctgtaa acacgggagg      660

gttgaagagg tggaagctcg ccggctcttc cagcagattc tgtctgccgt ggactactgt      720

cacaggcaca tggttgtcca cagggacctg aagccagaga acgtgttgct ggacgcccag      780

atgaatgcta agatagctga cttcggactc tctaatatga tgtcagatgg tgaatttcta      840

cgagacagct gtggatcgcc aaattatgca gcaccggagg tcatctcagg aaggctgtat      900

gcgggtcctg aggttgatat ctggagctgt ggtgttatcc tgtatgccct tctctgtggc      960

accctcccgt tcgacgatga gcacgtgcct acgctcttta agaagatccg agggggtgtg     1020

ttctacatcc cggagtatct caaccgttct attgccactc tgctgatgca catgctgcag     1080

gtggacccct tgaagcgagc aactatcaaa gacatacgag agcatgaatg gtttaaacag     1140

gatttgccca gttacctctt tcctgaagac ccctcctatg atgctaacgt cattgatgat     1200

gaggctgtga aagaagtatg tgaaaaattt gagtgtacag aatcagaagt gatgaacagt     1260

ttatacagtg gtgaccctca agaccagctc gcagtggctt atcatctcat cattgacaat     1320

cggagaataa tgaaccaagc cagtgagttc tacctcgcct ccagtcctcc aacgggttcc     1380

ttcatggacg atagtgccat gcatattccc cccggcctga aaccacatcc tgaaaggatg     1440

ccacctctca tagcagacag ccccaaagca cgctgtccac tggatgcact caacacaact     1500

aagcccaaat ctttagctgt gaaaaaagcc aagtggcacc ttgggatccg aagccagagc     1560

aaaccatacg acattatggc ggaggtgtac cgagctatga agcagctgga ctttgaatgg     1620

aaggtagtga atgcatacca tcttcgagta agaagaaaaa acccagtgac tggcaattac     1680

gtgaaaatga gcttacagct ttacctggtt gacaatcgga gctatctgct ggactttaaa     1740

agcatcgatg atgaggtggt ggagcagagg tctggttctt caacacctca gcgctcctgt     1800

tctgctgccg gcctccacag acctcggtca agtgtcgatt ccagcacagc cgagaaccat     1860

tcactgtctg gctctctcac tggttctttg actggcagca ctttgtcctc cgcttccccg     1920

cgcctgggca gtcataccat ggattttttt gaaatgtgcg ccagtcttat cactgcttta     1980

gcccgtaagc ttatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg     2040

gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc     2100

gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg     2160

ccctggccca ccctcgtgac caccctgacc tggggcgtgc agtgcttcag ccgctacccc     2220

gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag     2280

cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag     2340

ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac     2400

atcctggggc acaagctgga gtacaactac atcagccaca acgtctatat caccgccgac     2460

aagcagaaga acggcatcaa ggccaacttc aagatccgcc acaacatcga ggacggcagc     2520

gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg     2580

cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc     2640

gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag     2700

ctgtacaagt ccggactcag atctcgacga gctcactgat aactcgagag atccggctgc     2760

taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactagcata     2820

accccttggg gcctctaaac gggtcttgag gggttttttg gtttaaaccc atctaattgg     2880

actagtagcc cgcctaatga gcgggctttt ttttaattcc cctatttgtt tatttttcta     2940

aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata     3000

ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc     3060

ggcattttgc cttcctgttt ttgctcaccc agaaacgctc gtgaaagtaa aagacgcaga     3120

ggaccaattg ggggcacgag tgggatacat agaactggac ttgaatagcg gtaaaatcct     3180

tgagagtttt cgccctgaag agcgttttcc aatgatgagc actttcaaag ttctgctatg     3240

tggagcagta ttatcccgtg tagatgcggg gcaagagcaa ctcggacgac gaatacacta     3300

ttcgcagaat gacttggttg aatactcccc agtgacagaa aagcacctta cggacggaat     3360

gacggtaaga gaattatgta gtgccgccat aacgatgagt gataacactg cggcgaactt     3420

acttctgaca accatcggtg gaccgaagga attaaccgct tttttgcaca atatgggaga     3480

ccatgtaact cgccttgacc gttgggaacc agaactgaat gaagccatac caaacgacga     3540

gcgagacacc acaatgcctg cggcaatggc aacaacatta cgcaaactat taactggcga     3600

actacttact ctggcttcac ggcaacaatt aatagactgg cttgaagcgg ataaagttgc     3660

aggaccacta ctgcgttcgg cacttcctgc tggctggttt attgctgata aatctggggc     3720

aggagagcgt ggttcacggg gtatcattgc cgcacttgga ccagatggta agccttcccg     3780

tatcgtagtt atctacacga cgggtagtca ggcaactatg gacgaacgaa atagacagat     3840

tgctgaaata ggggcttcac tgattaagca ttggtaaacc gatacaatta aaggctcctt     3900

ttggagcctt tttttttgga cggaccggta gaaaagatca aaggatcttc ttgagatcct     3960

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt     4020

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg     4080

cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct     4140

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc     4200

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg     4260

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa     4320

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg     4380

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg     4440

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga     4500

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt     4560

ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct     4620

gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga     4680

acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcctgat gcggtatttt     4740

ctccttacgc atctgtgcgg tatttcacac cgcaatggtg cactctcagt acaatctgct     4800

ctgatgccgc atagttaagc cagtatacac tccgctatcg ctacgtgact gggtcatggc     4860

tgcgccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc     4920

atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc     4980

gtcatcaccg aaacgcgcga ggcaggg                                         5007


<210>  27
<211>  826
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat alpha2-CFP_T172d

<400>  27

Met Gly Ser Ser His His His His His His His His His His Ser Ser 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly His Met Ala Glu Lys Gln Lys His Asp 
            20                  25                  30          


Gly Arg Val Lys Ile Gly His Tyr Val Leu Gly Asp Thr Leu Gly Val 
        35                  40                  45              


Gly Thr Phe Gly Lys Val Lys Ile Gly Glu His Gln Leu Thr Gly His 
    50                  55                  60                  


Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg Ser Leu Asp 
65                  70                  75                  80  


Val Val Gly Lys Ile Lys Arg Glu Ile Gln Asn Leu Lys Leu Phe Arg 
                85                  90                  95      


His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr Pro Thr Asp 
            100                 105                 110         


Phe Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu Phe Asp Tyr 
        115                 120                 125             


Ile Cys Lys His Gly Arg Val Glu Glu Val Glu Ala Arg Arg Leu Phe 
    130                 135                 140                 


Gln Gln Ile Leu Ser Ala Val Asp Tyr Cys His Arg His Met Val Val 
145                 150                 155                 160 


His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala Gln Met Asn 
                165                 170                 175     


Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser Asp Gly Glu 
            180                 185                 190         


Phe Leu Arg Asp Ser Cys Gly Ser Pro Asn Tyr Ala Ala Pro Glu Val 
        195                 200                 205             


Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile Trp Ser Cys 
    210                 215                 220                 


Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro Phe Asp Asp 
225                 230                 235                 240 


Glu His Val Pro Thr Leu Phe Lys Lys Ile Arg Gly Gly Val Phe Tyr 
                245                 250                 255     


Ile Pro Glu Tyr Leu Asn Arg Ser Ile Ala Thr Leu Leu Met His Met 
            260                 265                 270         


Leu Gln Val Asp Pro Leu Lys Arg Ala Thr Ile Lys Asp Ile Arg Glu 
        275                 280                 285             


His Glu Trp Phe Lys Gln Asp Leu Pro Ser Tyr Leu Phe Pro Glu Asp 
    290                 295                 300                 


Pro Ser Tyr Asp Ala Asn Val Ile Asp Asp Glu Ala Val Lys Glu Val 
305                 310                 315                 320 


Cys Glu Lys Phe Glu Cys Thr Glu Ser Glu Val Met Asn Ser Leu Tyr 
                325                 330                 335     


Ser Gly Asp Pro Gln Asp Gln Leu Ala Val Ala Tyr His Leu Ile Ile 
            340                 345                 350         


Asp Asn Arg Arg Ile Met Asn Gln Ala Ser Glu Phe Tyr Leu Ala Ser 
        355                 360                 365             


Ser Pro Pro Thr Gly Ser Phe Met Asp Asp Ser Ala Met His Ile Pro 
    370                 375                 380                 


Pro Gly Leu Lys Pro His Pro Glu Arg Met Pro Pro Leu Ile Ala Asp 
385                 390                 395                 400 


Ser Pro Lys Ala Arg Cys Pro Leu Asp Ala Leu Asn Thr Thr Lys Pro 
                405                 410                 415     


Lys Ser Leu Ala Val Lys Lys Ala Lys Trp His Leu Gly Ile Arg Ser 
            420                 425                 430         


Gln Ser Lys Pro Tyr Asp Ile Met Ala Glu Val Tyr Arg Ala Met Lys 
        435                 440                 445             


Gln Leu Asp Phe Glu Trp Lys Val Val Asn Ala Tyr His Leu Arg Val 
    450                 455                 460                 


Arg Arg Lys Asn Pro Val Thr Gly Asn Tyr Val Lys Met Ser Leu Gln 
465                 470                 475                 480 


Leu Tyr Leu Val Asp Asn Arg Ser Tyr Leu Leu Asp Phe Lys Ser Ile 
                485                 490                 495     


Asp Asp Glu Val Val Glu Gln Arg Ser Gly Ser Ser Thr Pro Gln Arg 
            500                 505                 510         


Ser Cys Ser Ala Ala Gly Leu His Arg Pro Arg Ser Ser Val Asp Ser 
        515                 520                 525             


Ser Thr Ala Glu Asn His Ser Leu Ser Gly Ser Leu Thr Gly Ser Leu 
    530                 535                 540                 


Thr Gly Ser Thr Leu Ser Ser Ala Ser Pro Arg Leu Gly Ser His Thr 
545                 550                 555                 560 


Met Asp Phe Phe Glu Met Cys Ala Ser Leu Ile Thr Ala Leu Ala Arg 
                565                 570                 575     


Lys Leu Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
            580                 585                 590         


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
        595                 600                 605             


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
    610                 615                 620                 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
625                 630                 635                 640 


Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
                645                 650                 655     


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
            660                 665                 670         


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
        675                 680                 685             


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
    690                 695                 700                 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
705                 710                 715                 720 


Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln 
                725                 730                 735     


Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
            740                 745                 750         


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
        755                 760                 765             


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
    770                 775                 780                 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
785                 790                 795                 800 


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
                805                 810                 815     


Lys Ser Gly Leu Arg Ser Arg Arg Ala His 
            820                 825     


<210>  28
<211>  2839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1_L128D+V129D, pDS plasmid

<400>  28
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga taatacgact cactataggg gaattgtgag      900

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat      960

ggagtcggtt gctgcagaga gcgctccagc tccggagaat gaacactctc aagagacccc     1020

ggaatcgaac agtagtgtgt acaccacctt catgaagtct catcgctgct atgacctgat     1080

ccccacaagc tccaagctgg tggtatttga tacttcgctg caggtaaaga aagccttctt     1140

tgccctggtg actaacggtg ttcgtgctgc ccctttgtgg gatagtaaga agcagagctt     1200

tgtgggcatg ctgaccatca ctgacttcat caatattctg caccgatact acaagtcagc     1260

cctggtgcag atctatgaac tggaggagca caagatagag acttggagag aggtctacct     1320

gcaggactcc tttaagccag atgattgcat ttctccaaat gccagcttgt tcgatgctgt     1380

ctcttcatta attcgaaata agatccacag gcttccagtt attgacccgg agtcaggcaa     1440

caccttgtac attcttactc acaagcggat cctcaagttc ctcaagttgt ttatcactga     1500

gttccccaag ccggaattca tgtctaagtc tctggaagag ctacagattg gcacctacgc     1560

caatattgcc atggtccgta ccactacacc tgtctatgtg gctctgggca tctttgtaca     1620

gcaccgagtc tccgccttgc ctgtggtgga tgagaaaggg cgtgtggtgg acatctactc     1680

caagtttgat gtgattaatt tggcagcaga aaagacatac aacaacctag atgtgtctgt     1740

gacaaaagcc ctacagcacc ggtcacacta cttcgagggt gttctcaagt gctacctaca     1800

tgagactcta gaagcaatca tcaatagact ggtggaagca gaggttcacc gtctggtggt     1860

ggtggatgaa catgacgtgg tcaagggcat tgtatcgctg tctgacatct tacaggctct     1920

ggtgctcaca ggtggagaga agaagccctg ataactagtt ccgtttaaac ccatgtgcct     1980

ggcagataac ttcgtataat gtatgctata cgaagttatg gtacgtacta agctctcatg     2040

tttcacgtac taagctctca tgtttaacgt actaagctct catgtttaac gaactaaacc     2100

ctcatggcta acgtactaag ctctcatggc taacgtacta agctctcatg tttcacgtac     2160

taagctctca tgtttgaaca ataaaattaa tataaatcag caacttaaat agcctctaag     2220

gttttaagtt ttataagaaa aaaaagaata tataaggctt ttaaagcttt taaggtttaa     2280

cggttgtgga caacaagcca gggatgtaac gcactgagaa gcccttagag cctctcaaag     2340

caattttgag tgacacagga acacttaacg gctgacataa ttcagcttca cgctgccgca     2400

agcactcagg gcgcaagggc tgctaaagga agcggaacac gtagaaagcc agtccgcaga     2460

aacggtgctg accccggatg aatgtcagct gggaggcaga ataaatgatc atatcgtcaa     2520

ttattacctc cacggggaga gcctgagcaa actggcctca ggcatttgag aagcacacgg     2580

tcacactgct tccggtagtc aataaaccgg taagtagcgt atgcgctcac gcaactggtc     2640

cagaaccttg accgaacgca gcggtggtaa cggcgcagtg gcggttttca tggcttgtta     2700

tgactgtttt tttggggtac agtctatgcc tcgggcatcc aagcagcaag cgcgttacgc     2760

cgtgggtcga tgtttgatgt tatggagcag caacgatgtt acgcagcagg gcagtcgccc     2820

taaaacaaag ttaaacatc                                                  2839


<210>  29
<211>  330
<212>  PRT
<213>  Rat gamma1_L128D+V129D

<400>  29

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Asp 
        115                 120                 125             


Asp Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro 
                325                 330 


<210>  30
<211>  2839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1_S315P, pDS plasmid

<400>  30
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga taatacgact cactataggg gaattgtgag      900

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat      960

ggagtcggtt gctgcagaga gcgctccagc tccggagaat gaacactctc aagagacccc     1020

ggaatcgaac agtagtgtgt acaccacctt catgaagtct catcgctgct atgacctgat     1080

ccccacaagc tccaagctgg tggtatttga tacttcgctg caggtaaaga aagccttctt     1140

tgccctggtg actaacggtg ttcgtgctgc ccctttgtgg gatagtaaga agcagagctt     1200

tgtgggcatg ctgaccatca ctgacttcat caatattctg caccgatact acaagtcagc     1260

cctggtgcag atctatgaac tggaggagca caagatagag acttggagag aggtctacct     1320

gcaagactcc tttaagccac ttgtctgcat ttctccaaat gccagcttgt tcgatgctgt     1380

ctcttcatta attcgaaata agatccacag gcttccagtt attgacccgg agtcaggcaa     1440

caccttgtac attcttactc acaagcggat cctcaagttc ctcaagttgt ttatcactga     1500

gttccccaag ccggaattca tgtctaagtc tctggaagag ctacagattg gcacctacgc     1560

caatattgcc atggtccgta ccactacacc tgtctatgtg gctctgggca tctttgtaca     1620

gcaccgagtc tccgccttgc ctgtggtgga tgagaaaggg cgtgtggtgg acatctactc     1680

caagtttgat gtgattaatt tggcagcaga aaagacatac aacaacctag atgtgtctgt     1740

gacaaaagcc ctacagcacc ggtcacacta cttcgagggt gttctcaagt gctacctaca     1800

tgagactcta gaagcaatca tcaatagact ggtggaagca gaggttcacc gtctggtggt     1860

ggtggatgaa catgacgtgg tcaagggcat tgtatcgctg cccgatatct tacaggctct     1920

ggtgctcaca ggtggagaga agaagccctg ataactagtt ccgtttaaac ccatgtgcct     1980

ggcagataac ttcgtataat gtatgctata cgaagttatg gtacgtacta agctctcatg     2040

tttcacgtac taagctctca tgtttaacgt actaagctct catgtttaac gaactaaacc     2100

ctcatggcta acgtactaag ctctcatggc taacgtacta agctctcatg tttcacgtac     2160

taagctctca tgtttgaaca ataaaattaa tataaatcag caacttaaat agcctctaag     2220

gttttaagtt ttataagaaa aaaaagaata tataaggctt ttaaagcttt taaggtttaa     2280

cggttgtgga caacaagcca gggatgtaac gcactgagaa gcccttagag cctctcaaag     2340

caattttgag tgacacagga acacttaacg gctgacataa ttcagcttca cgctgccgca     2400

agcactcagg gcgcaagggc tgctaaagga agcggaacac gtagaaagcc agtccgcaga     2460

aacggtgctg accccggatg aatgtcagct gggaggcaga ataaatgatc atatcgtcaa     2520

ttattacctc cacggggaga gcctgagcaa actggcctca ggcatttgag aagcacacgg     2580

tcacactgct tccggtagtc aataaaccgg taagtagcgt atgcgctcac gcaactggtc     2640

cagaaccttg accgaacgca gcggtggtaa cggcgcagtg gcggttttca tggcttgtta     2700

tgactgtttt tttggggtac agtctatgcc tcgggcatcc aagcagcaag cgcgttacgc     2760

cgtgggtcga tgtttgatgt tatggagcag caacgatgtt acgcagcagg gcagtcgccc     2820

taaaacaaag ttaaacatc                                                  2839


<210>  31
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat gamma1_S315P

<400>  31

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Pro Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro 
                325                 330 


<210>  32
<211>  2839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1_V275G+L276G, pDS plasmid

<400>  32
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga taatacgact cactataggg gaattgtgag      900

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat      960

ggagtcggtt gctgcagaga gcgctccagc tccggagaat gaacactctc aagagacccc     1020

ggaatcgaac agtagtgtgt acaccacctt catgaagtct catcgctgct atgacctgat     1080

ccccacaagc tccaagctgg tggtatttga tacttcgctg caggtaaaga aagccttctt     1140

tgccctggtg actaacggtg ttcgtgctgc ccctttgtgg gatagtaaga agcagagctt     1200

tgtgggcatg ctgaccatca ctgacttcat caatattctg caccgatact acaagtcagc     1260

cctggtgcag atctatgaac tggaggagca caagatagag acttggagag aggtctacct     1320

gcaagactcc tttaagccac ttgtctgcat ttctccaaat gccagcttgt tcgatgctgt     1380

ctcttcatta attcgaaata agatccacag gcttccagtt attgacccgg agtcaggcaa     1440

caccttgtac attcttactc acaagcggat cctcaagttc ctcaagttgt ttatcactga     1500

gttccccaag ccggaattca tgtctaagtc tctggaagag ctacagattg gcacctacgc     1560

caatattgcc atggtccgta ccactacacc tgtctatgtg gctctgggca tctttgtaca     1620

gcaccgagtc tccgccttgc ctgtggtgga tgagaaaggg cgtgtggtgg acatctactc     1680

caagtttgat gtgattaatt tggcagcaga aaagacatac aacaacctag atgtgtctgt     1740

gacaaaagcc ctacagcacc ggtcacacta cttcgagggt ggaggtaagt gctacctaca     1800

tgagactctc gaggcaatca tcaatagact ggtggaagca gaggttcacc gtctggtggt     1860

ggtggatgaa catgacgtgg tcaagggcat tgtatcgctg tctgacatct tacaggctct     1920

ggtgctcaca ggtggagaga agaagccctg ataactagtt ccgtttaaac ccatgtgcct     1980

ggcagataac ttcgtataat gtatgctata cgaagttatg gtacgtacta agctctcatg     2040

tttcacgtac taagctctca tgtttaacgt actaagctct catgtttaac gaactaaacc     2100

ctcatggcta acgtactaag ctctcatggc taacgtacta agctctcatg tttcacgtac     2160

taagctctca tgtttgaaca ataaaattaa tataaatcag caacttaaat agcctctaag     2220

gttttaagtt ttataagaaa aaaaagaata tataaggctt ttaaagcttt taaggtttaa     2280

cggttgtgga caacaagcca gggatgtaac gcactgagaa gcccttagag cctctcaaag     2340

caattttgag tgacacagga acacttaacg gctgacataa ttcagcttca cgctgccgca     2400

agcactcagg gcgcaagggc tgctaaagga agcggaacac gtagaaagcc agtccgcaga     2460

aacggtgctg accccggatg aatgtcagct gggaggcaga ataaatgatc atatcgtcaa     2520

ttattacctc cacggggaga gcctgagcaa actggcctca ggcatttgag aagcacacgg     2580

tcacactgct tccggtagtc aataaaccgg taagtagcgt atgcgctcac gcaactggtc     2640

cagaaccttg accgaacgca gcggtggtaa cggcgcagtg gcggttttca tggcttgtta     2700

tgactgtttt tttggggtac agtctatgcc tcgggcatcc aagcagcaag cgcgttacgc     2760

cgtgggtcga tgtttgatgt tatggagcag caacgatgtt acgcagcagg gcagtcgccc     2820

taaaacaaag ttaaacatc                                                  2839


<210>  33
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat gamma1_V275G+L276G

<400>  33

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Gly Gly Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro 
                325                 330 


<210>  34
<211>  3640
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-YFP_L128D+V129D, pDS plasmid

<400>  34
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga taatacgact cactataggg gaattgtgag      900

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat      960

ggagtcggtt gctgcagaga gcgctccagc tccggagaat gaacactctc aagagacccc     1020

ggaatcgaac agtagtgtgt acaccacctt catgaagtct catcgctgct atgacctgat     1080

ccccacaagc tccaagctgg tggtatttga tacttcgctg caggtaaaga aagccttctt     1140

tgccctggtg actaacggtg ttcgtgctgc ccctttgtgg gatagtaaga agcagagctt     1200

tgtgggcatg ctgaccatca ctgacttcat caatattctg caccgatact acaagtcagc     1260

cctggtgcag atctatgaac tggaggagca caagatagag acttggagag aggtctacct     1320

gcaggactcc tttaagccag atgattgcat ttctccaaat gccagcttgt tcgatgctgt     1380

ctcttcatta attcgaaata agatccacag gcttccagtt attgacccgg agtcaggcaa     1440

caccttgtac attcttactc acaagcggat cctcaagttc ctcaagttgt ttatcactga     1500

gttccccaag ccggaattca tgtctaagtc tctggaagag ctacagattg gcacctacgc     1560

caatattgcc atggtccgta ccactacacc tgtctatgtg gctctgggca tctttgtaca     1620

gcaccgagtc tccgccttgc ctgtggtgga tgagaaaggg cgtgtggtgg acatctactc     1680

caagtttgat gtgattaatt tggcagcaga aaagacatac aacaacctag atgtgtctgt     1740

gacaaaagcc ctacagcacc ggtcacacta cttcgagggt gttctcaagt gctacctaca     1800

tgagactcta gaagcaatca tcaatagact ggtggaagca gaggttcacc gtctggtggt     1860

ggtggatgaa catgacgtgg tcaagggcat tgtatcgctg tctgacatct tacaggctct     1920

ggtgctcaca ggtggagaga agaagcccgc tagcatggtg agcaagggcg aggagctgtt     1980

caccggggtg gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag     2040

cgtgtccggc gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg     2100

caccaccggc aagctgcccg tgccctggcc caccctcgtg accaccttcg gctacggcct     2160

gcagtgcttc gcccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat     2220

gcccgaaggc tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac     2280

ccgcgccgag gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat     2340

cgacttcaag gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca     2400

caacgtctat atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg     2460

ccacaacatc gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat     2520

cggcgacggc cccgtgctgc tgcccgacaa ccactacctg agctaccagt ccgccctgag     2580

caaagacccc aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg     2640

gatcactctc ggcatggacg agctgtacaa gtccggactc agatctcgag ctcaagcttc     2700

gaattctgca gtcgacggta ccgcgggccc gggatccacc ggatctagat gataactagt     2760

tccgtttaaa cccatgtgcc tggcagataa cttcgtataa tgtatgctat acgaagttat     2820

ggtacgtact aagctctcat gtttcacgta ctaagctctc atgtttaacg tactaagctc     2880

tcatgtttaa cgaactaaac cctcatggct aacgtactaa gctctcatgg ctaacgtact     2940

aagctctcat gtttcacgta ctaagctctc atgtttgaac aataaaatta atataaatca     3000

gcaacttaaa tagcctctaa ggttttaagt tttataagaa aaaaaagaat atataaggct     3060

tttaaagctt ttaaggttta acggttgtgg acaacaagcc agggatgtaa cgcactgaga     3120

agcccttaga gcctctcaaa gcaattttga gtgacacagg aacacttaac ggctgacata     3180

attcagcttc acgctgccgc aagcactcag ggcgcaaggg ctgctaaagg aagcggaaca     3240

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tgggaggcag     3300

aataaatgat catatcgtca attattacct ccacggggag agcctgagca aactggcctc     3360

aggcatttga gaagcacacg gtcacactgc ttccggtagt caataaaccg gtaagtagcg     3420

tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta acggcgcagt     3480

ggcggttttc atggcttgtt atgactgttt ttttggggta cagtctatgc ctcgggcatc     3540

caagcagcaa gcgcgttacg ccgtgggtcg atgtttgatg ttatggagca gcaacgatgt     3600

tacgcagcag ggcagtcgcc ctaaaacaaa gttaaacatc                           3640


<210>  35
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-YFP_L128D+V129D

<400>  35

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Asp 
        115                 120                 125             


Asp Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro Ala Ser Met Val Ser Lys 
                325                 330                 335     


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
            340                 345                 350         


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
        355                 360                 365             


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
    370                 375                 380                 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly 
385                 390                 395                 400 


Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
                405                 410                 415     


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
            420                 425                 430         


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
        435                 440                 445             


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
    450                 455                 460                 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser 
465                 470                 475                 480 


His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val 
                485                 490                 495     


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
            500                 505                 510         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        515                 520                 525             


Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro 
    530                 535                 540                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
545                 550                 555                 560 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser 
                565                 570                 575     


Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr Ala Gly Pro Gly 
            580                 585                 590         


Ser Thr Gly Ser Arg 
        595         


<210>  36
<211>  3640
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-YFP_V275G+L276G, pDS plasmid

<400>  36
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga taatacgact cactataggg gaattgtgag      900

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat      960

ggagtcggtt gctgcagaga gcgctccagc tccggagaat gaacactctc aagagacccc     1020

ggaatcgaac agtagtgtgt acaccacctt catgaagtct catcgctgct atgacctgat     1080

ccccacaagc tccaagctgg tggtatttga tacttcgctg caggtaaaga aagccttctt     1140

tgccctggtg actaacggtg ttcgtgctgc ccctttgtgg gatagtaaga agcagagctt     1200

tgtgggcatg ctgaccatca ctgacttcat caatattctg caccgatact acaagtcagc     1260

cctggtgcag atctatgaac tggaggagca caagatagag acttggagag aggtctacct     1320

gcaagactcc tttaagccac ttgtctgcat ttctccaaat gccagcttgt tcgatgctgt     1380

ctcttcatta attcgaaata agatccacag gcttccagtt attgacccgg agtcaggcaa     1440

caccttgtac attcttactc acaagcggat cctcaagttc ctcaagttgt ttatcactga     1500

gttccccaag ccggaattca tgtctaagtc tctggaagag ctacagattg gcacctacgc     1560

caatattgcc atggtccgta ccactacacc tgtctatgtg gctctgggca tctttgtaca     1620

gcaccgagtc tccgccttgc ctgtggtgga tgagaaaggg cgtgtggtgg acatctactc     1680

caagtttgat gtgattaatt tggcagcaga aaagacatac aacaacctag atgtgtctgt     1740

gacaaaagcc ctacagcacc ggtcacacta cttcgagggt ggaggtaagt gctacctaca     1800

tgagactctc gaggcaatca tcaatagact ggtggaagca gaggttcacc gtctggtggt     1860

ggtggatgaa catgacgtgg tcaagggcat tgtatcgctg tctgacatct tacaggctct     1920

ggtgctcaca ggtggagaga agaagcccgc tagcatggtg agcaagggcg aggagctgtt     1980

caccggggtg gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag     2040

cgtgtccggc gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg     2100

caccaccggc aagctgcccg tgccctggcc caccctcgtg accaccttcg gctacggcct     2160

gcagtgcttc gcccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat     2220

gcccgaaggc tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac     2280

ccgcgccgag gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat     2340

cgacttcaag gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca     2400

caacgtctat atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg     2460

ccacaacatc gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat     2520

cggcgacggc cccgtgctgc tgcccgacaa ccactacctg agctaccagt ccgccctgag     2580

caaagacccc aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg     2640

gatcactctc ggcatggacg agctgtacaa gtccggactc agatctcgag ctcaagcttc     2700

gaattctgca gtcgacggta ccgcgggccc gggatccacc ggatctagat gataactagt     2760

tccgtttaaa cccatgtgcc tggcagataa cttcgtataa tgtatgctat acgaagttat     2820

ggtacgtact aagctctcat gtttcacgta ctaagctctc atgtttaacg tactaagctc     2880

tcatgtttaa cgaactaaac cctcatggct aacgtactaa gctctcatgg ctaacgtact     2940

aagctctcat gtttcacgta ctaagctctc atgtttgaac aataaaatta atataaatca     3000

gcaacttaaa tagcctctaa ggttttaagt tttataagaa aaaaaagaat atataaggct     3060

tttaaagctt ttaaggttta acggttgtgg acaacaagcc agggatgtaa cgcactgaga     3120

agcccttaga gcctctcaaa gcaattttga gtgacacagg aacacttaac ggctgacata     3180

attcagcttc acgctgccgc aagcactcag ggcgcaaggg ctgctaaagg aagcggaaca     3240

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tgggaggcag     3300

aataaatgat catatcgtca attattacct ccacggggag agcctgagca aactggcctc     3360

aggcatttga gaagcacacg gtcacactgc ttccggtagt caataaaccg gtaagtagcg     3420

tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta acggcgcagt     3480

ggcggttttc atggcttgtt atgactgttt ttttggggta cagtctatgc ctcgggcatc     3540

caagcagcaa gcgcgttacg ccgtgggtcg atgtttgatg ttatggagca gcaacgatgt     3600

tacgcagcag ggcagtcgcc ctaaaacaaa gttaaacatc                           3640


<210>  37
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-YFP_V275G+L276G

<400>  37

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Gly Gly Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro Ala Ser Met Val Ser Lys 
                325                 330                 335     


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
            340                 345                 350         


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
        355                 360                 365             


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
    370                 375                 380                 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly 
385                 390                 395                 400 


Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
                405                 410                 415     


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
            420                 425                 430         


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
        435                 440                 445             


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
    450                 455                 460                 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser 
465                 470                 475                 480 


His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val 
                485                 490                 495     


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
            500                 505                 510         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        515                 520                 525             


Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro 
    530                 535                 540                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
545                 550                 555                 560 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser 
                565                 570                 575     


Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr Ala Gly Pro Gly 
            580                 585                 590         


Ser Thr Gly Ser Arg 
        595         


<210>  38
<211>  3640
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-YFP_S315P, pDS plasmid

<400>  38
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga taatacgact cactataggg gaattgtgag      900

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat      960

ggagtcggtt gctgcagaga gcgctccagc tccggagaat gaacactctc aagagacccc     1020

ggaatcgaac agtagtgtgt acaccacctt catgaagtct catcgctgct atgacctgat     1080

ccccacaagc tccaagctgg tggtatttga tacttcgctg caggtaaaga aagccttctt     1140

tgccctggtg actaacggtg ttcgtgctgc ccctttgtgg gatagtaaga agcagagctt     1200

tgtgggcatg ctgaccatca ctgacttcat caatattctg caccgatact acaagtcagc     1260

cctggtgcag atctatgaac tggaggagca caagatagag acttggagag aggtctacct     1320

gcaagactcc tttaagccac ttgtctgcat ttctccaaat gccagcttgt tcgatgctgt     1380

ctcttcatta attcgaaata agatccacag gcttccagtt attgacccgg agtcaggcaa     1440

caccttgtac attcttactc acaagcggat cctcaagttc ctcaagttgt ttatcactga     1500

gttccccaag ccggaattca tgtctaagtc tctggaagag ctacagattg gcacctacgc     1560

caatattgcc atggtccgta ccactacacc tgtctatgtg gctctgggca tctttgtaca     1620

gcaccgagtc tccgccttgc ctgtggtgga tgagaaaggg cgtgtggtgg acatctactc     1680

caagtttgat gtgattaatt tggcagcaga aaagacatac aacaacctag atgtgtctgt     1740

gacaaaagcc ctacagcacc ggtcacacta cttcgagggt gttctcaagt gctacctaca     1800

tgagactcta gaagcaatca tcaatagact ggtggaagca gaggttcacc gtctggtggt     1860

ggtggatgaa catgacgtgg tcaagggcat tgtatcgctg cccgatatct tacaggctct     1920

ggtgctcaca ggtggagaga agaagcccgc tagcatggtg agcaagggcg aggagctgtt     1980

caccggggtg gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag     2040

cgtgtccggc gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg     2100

caccaccggc aagctgcccg tgccctggcc caccctcgtg accaccttcg gctacggcct     2160

gcagtgcttc gcccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat     2220

gcccgaaggc tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac     2280

ccgcgccgag gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat     2340

cgacttcaag gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca     2400

caacgtctat atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg     2460

ccacaacatc gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat     2520

cggcgacggc cccgtgctgc tgcccgacaa ccactacctg agctaccagt ccgccctgag     2580

caaagacccc aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg     2640

gatcactctc ggcatggacg agctgtacaa gtccggactc agatctcgag ctcaagcttc     2700

gaattctgca gtcgacggta ccgcgggccc gggatccacc ggatctagat gataactagt     2760

tccgtttaaa cccatgtgcc tggcagataa cttcgtataa tgtatgctat acgaagttat     2820

ggtacgtact aagctctcat gtttcacgta ctaagctctc atgtttaacg tactaagctc     2880

tcatgtttaa cgaactaaac cctcatggct aacgtactaa gctctcatgg ctaacgtact     2940

aagctctcat gtttcacgta ctaagctctc atgtttgaac aataaaatta atataaatca     3000

gcaacttaaa tagcctctaa ggttttaagt tttataagaa aaaaaagaat atataaggct     3060

tttaaagctt ttaaggttta acggttgtgg acaacaagcc agggatgtaa cgcactgaga     3120

agcccttaga gcctctcaaa gcaattttga gtgacacagg aacacttaac ggctgacata     3180

attcagcttc acgctgccgc aagcactcag ggcgcaaggg ctgctaaagg aagcggaaca     3240

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tgggaggcag     3300

aataaatgat catatcgtca attattacct ccacggggag agcctgagca aactggcctc     3360

aggcatttga gaagcacacg gtcacactgc ttccggtagt caataaaccg gtaagtagcg     3420

tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta acggcgcagt     3480

ggcggttttc atggcttgtt atgactgttt ttttggggta cagtctatgc ctcgggcatc     3540

caagcagcaa gcgcgttacg ccgtgggtcg atgtttgatg ttatggagca gcaacgatgt     3600

tacgcagcag ggcagtcgcc ctaaaacaaa gttaaacatc                           3640


<210>  39
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-YFP_S315P

<400>  39

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Pro Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro Ala Ser Met Val Ser Lys 
                325                 330                 335     


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
            340                 345                 350         


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
        355                 360                 365             


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
    370                 375                 380                 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly 
385                 390                 395                 400 


Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
                405                 410                 415     


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
            420                 425                 430         


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
        435                 440                 445             


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
    450                 455                 460                 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser 
465                 470                 475                 480 


His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val 
                485                 490                 495     


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
            500                 505                 510         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        515                 520                 525             


Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro 
    530                 535                 540                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
545                 550                 555                 560 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser 
                565                 570                 575     


Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr Ala Gly Pro Gly 
            580                 585                 590         


Ser Thr Gly Ser Arg 
        595         


<210>  40
<211>  2839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1, T7 Promoter

<400>  40
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga taatacgact cactataggg gaattgtgag      900

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat      960

ggagtcggtt gctgcagaga gcgctccagc tccggagaat gaacactctc aagagacccc     1020

ggaatcgaac agtagtgtgt acaccacctt catgaagtct catcgctgct atgacctgat     1080

ccccacaagc tccaagctgg tggtatttga tacttcgctg caggtaaaga aagccttctt     1140

tgccctggtg actaacggtg ttcgtgctgc ccctttgtgg gatagtaaga agcagagctt     1200

tgtgggcatg ctgaccatca ctgacttcat caatattctg caccgatact acaagtcagc     1260

cctggtgcag atctatgaac tggaggagca caagatagag acttggagag aggtctacct     1320

gcaagactcc tttaagccac ttgtctgcat ttctccaaat gccagcttgt tcgatgctgt     1380

ctcttcatta attcgaaata agatccacag gcttccagtt attgacccgg agtcaggcaa     1440

caccttgtac attcttactc acaagcggat cctcaagttc ctcaagttgt ttatcactga     1500

gttccccaag ccggaattca tgtctaagtc tctggaagag ctacagattg gcacctacgc     1560

caatattgcc atggtccgta ccactacacc tgtctatgtg gctctgggca tctttgtaca     1620

gcaccgagtc tccgccttgc ctgtggtgga tgagaaaggg cgtgtggtgg acatctactc     1680

caagtttgat gtgattaatt tggcagcaga aaagacatac aacaacctag atgtgtctgt     1740

gacaaaagcc ctacagcacc ggtcacacta cttcgagggt gttctcaagt gctacctaca     1800

tgagactcta gaagcaatca tcaatagact ggtggaagca gaggttcacc gtctggtggt     1860

ggtggatgaa catgacgtgg tcaagggcat tgtatcgctg tctgacatct tacaggctct     1920

ggtgctcaca ggtggagaga agaagccctg ataactagtt ccgtttaaac ccatgtgcct     1980

ggcagataac ttcgtataat gtatgctata cgaagttatg gtacgtacta agctctcatg     2040

tttcacgtac taagctctca tgtttaacgt actaagctct catgtttaac gaactaaacc     2100

ctcatggcta acgtactaag ctctcatggc taacgtacta agctctcatg tttcacgtac     2160

taagctctca tgtttgaaca ataaaattaa tataaatcag caacttaaat agcctctaag     2220

gttttaagtt ttataagaaa aaaaagaata tataaggctt ttaaagcttt taaggtttaa     2280

cggttgtgga caacaagcca gggatgtaac gcactgagaa gcccttagag cctctcaaag     2340

caattttgag tgacacagga acacttaacg gctgacataa ttcagcttca cgctgccgca     2400

agcactcagg gcgcaagggc tgctaaagga agcggaacac gtagaaagcc agtccgcaga     2460

aacggtgctg accccggatg aatgtcagct gggaggcaga ataaatgatc atatcgtcaa     2520

ttattacctc cacggggaga gcctgagcaa actggcctca ggcatttgag aagcacacgg     2580

tcacactgct tccggtagtc aataaaccgg taagtagcgt atgcgctcac gcaactggtc     2640

cagaaccttg accgaacgca gcggtggtaa cggcgcagtg gcggttttca tggcttgtta     2700

tgactgtttt tttggggtac agtctatgcc tcgggcatcc aagcagcaag cgcgttacgc     2760

cgtgggtcga tgtttgatgt tatggagcag caacgatgtt acgcagcagg gcagtcgccc     2820

taaaacaaag ttaaacatc                                                  2839


<210>  41
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  41

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro 
                325                 330 


<210>  42
<211>  3589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-eCFP, pDS plasmid, T7 promoter

<400>  42
ccggtaagta gcgtatgcgc tcacgcaact ggtccagaac cttgaccgaa cgcagcggtg       60

gtaacggcgc agtggcggtt ttcatggctt gttatgactg tttttttggg gtacagtcta      120

tgcctcgggc atccaagcag caagcgcgtt acgccgtggg tcgatgtttg atgttatgga      180

gcagcaacga tgttacgcag cagggcagtc gccctaaaac aaagttaaac atcatgaggg      240

aagcggtgat cgccgaagta tcgactcaac tatcagaggt agttggcgtc atcgagcgcc      300

atctcgaacc gacgttgctg gccgtacatt tgtacggctc cgcagtggat ggcggcctga      360

agccacacag tgatattgat ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc      420

ggcgagcttt gatcaacgac cttttggaaa cttcggcttc ccctggagag agcgagattc      480

tccgcgctgt agaagtcacc attgttgtgc acgacgacat cattccgtgg cgttatccag      540

ctaagcgcga actgcaattt ggagaatggc agcgcaatga cattcttgca ggtatcttcg      600

agccagccac gatcgacatt gatctggcta tcttgctgac aaaagcaaga gaacatagcg      660

ttgccttggt aggtccagcg gcggaggaac tctttgatcc ggttcctgaa caggatctat      720

ttgaggcgct aaatgaaacc ttaacgctat ggaactcgcc gcccgactgg gctggcgatg      780

agcgaaatgt agtgcttacg ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg      840

cgccgaagga tgtcgctgcc gactgggcaa tggagcgcct gccggcccag tatcagcccg      900

tcatacttga agctagacag gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg      960

cagatcagtt ggaagaattt gtccactacg tgaaaggcga gatcaccaag gtagtcggca     1020

aataatgtct aacaattcgt tcaagccgac ggatctatgt cgggtgcgga gaaagaggta     1080

atgaaatggc acctaggtat cgataatacg actcactata ggggaattgt gagcggataa     1140

caattcccct ctagaaataa ttttgtttaa ctttaagaag gagatataca tatggagtcg     1200

gttgctgcag agagcgctcc agctccggag aatgaacact ctcaagagac cccggaatcg     1260

aacagtagtg tgtacaccac cttcatgaag tctcatcgct gctatgacct gatccccaca     1320

agctccaagc tggtggtatt tgatacttcg ctgcaggtaa agaaagcctt ctttgccctg     1380

gtgactaacg gtgttcgtgc tgcccctttg tgggatagta agaagcagag ctttgtgggc     1440

atgctgacca tcactgactt catcaatatt ctgcaccgat actacaagtc agccctggtg     1500

cagatctatg aactggagga gcacaagata gagacttgga gagaggtcta cctgcaagac     1560

tcctttaagc cacttgtctg catttctcca aatgccagct tgttcgatgc tgtctcttca     1620

ttaattcgaa ataagatcca caggcttcca gttattgacc cggagtcagg caacaccttg     1680

tacattctta ctcacaagcg gatcctcaag ttcctcaagt tgtttatcac tgagttcccc     1740

aagccggaat tcatgtctaa gtctctggaa gagctacaga ttggcaccta cgccaatatt     1800

gccatggtcc gtaccactac acctgtctat gtggctctgg gcatctttgt acagcaccga     1860

gtctccgcct tgcctgtggt ggatgagaaa gggcgtgtgg tggacatcta ctccaagttt     1920

gatgtgatta atttggcagc agaaaagaca tacaacaacc tagatgtgtc tgtgacaaaa     1980

gccctacagc accggtcaca ctacttcgag ggtgttctca agtgctacct acatgagact     2040

ctagaagcaa tcatcaatag actggtggaa gcagaggttc accgtctggt ggtggtggat     2100

gaacatgacg tggtcaaggg cattgtatcg ctgtctgaca tcttacaggc tctggtgctc     2160

acaggtggag agaagaagcc cgctagcatg gtgagcaagg gcgaggagct gttcaccggg     2220

gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt cagcgtgtcc     2280

ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat ctgcaccacc     2340

ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctgggg cgtgcagtgc     2400

ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc catgcccgaa     2460

ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa gacccgcgcc     2520

gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg catcgacttc     2580

aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacatcag ccacaacgtc     2640

tatatcaccg ccgacaagca gaagaacggc atcaaggcca acttcaagat ccgccacaac     2700

atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc catcggcgac     2760

ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct gagcaaagac     2820

cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc cgggatcact     2880

ctcggcatgg acgagctgta caagtccgga ctcagatctc gacgagctca ctgataacta     2940

gttccgttta aacccatgtg cctggcagat aacttcgtat aatgtatgct atacgaagtt     3000

atggtacgta ctaagctctc atgtttcacg tactaagctc tcatgtttaa cgtactaagc     3060

tctcatgttt aacgaactaa accctcatgg ctaacgtact aagctctcat ggctaacgta     3120

ctaagctctc atgtttcacg tactaagctc tcatgtttga acaataaaat taatataaat     3180

cagcaactta aatagcctct aaggttttaa gttttataag aaaaaaaaga atatataagg     3240

cttttaaagc ttttaaggtt taacggttgt ggacaacaag ccagggatgt aacgcactga     3300

gaagccctta gagcctctca aagcaatttt gagtgacaca ggaacactta acggctgaca     3360

taattcagct tcacgctgcc gcaagcactc agggcgcaag ggctgctaaa ggaagcggaa     3420

cacgtagaaa gccagtccgc agaaacggtg ctgaccccgg atgaatgtca gctgggaggc     3480

agaataaatg atcatatcgt caattattac ctccacgggg agagcctgag caaactggcc     3540

tcaggcattt gagaagcaca cggtcacact gcttccggta gtcaataaa                 3589


<210>  43
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-eCFP, T7 promoter

<400>  43

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro Ala Ser Met Val Ser Lys 
                325                 330                 335     


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
            340                 345                 350         


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
        355                 360                 365             


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
    370                 375                 380                 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Trp Gly 
385                 390                 395                 400 


Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
                405                 410                 415     


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
            420                 425                 430         


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
        435                 440                 445             


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
    450                 455                 460                 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Ile Ser 
465                 470                 475                 480 


His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
                485                 490                 495     


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
            500                 505                 510         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        515                 520                 525             


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro 
    530                 535                 540                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
545                 550                 555                 560 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser 
                565                 570                 575     


Arg Arg Ala His 
            580 


<210>  44
<211>  3589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat eCFP-gamma1, pDS plasmid, T7 promoter

<400>  44
tattacctcc acggggagag cctgagcaaa ctggcctcag gcatttgaga agcacacggt       60

cacactgctt ccggtagtca ataaaccggt aagtagcgta tgcgctcacg caactggtcc      120

agaaccttga ccgaacgcag cggtggtaac ggcgcagtgg cggttttcat ggcttgttat      180

gactgttttt ttggggtaca gtctatgcct cgggcatcca agcagcaagc gcgttacgcc      240

gtgggtcgat gtttgatgtt atggagcagc aacgatgtta cgcagcaggg cagtcgccct      300

aaaacaaagt taaacatcat gagggaagcg gtgatcgccg aagtatcgac tcaactatca      360

gaggtagttg gcgtcatcga gcgccatctc gaaccgacgt tgctggccgt acatttgtac      420

ggctccgcag tggatggcgg cctgaagcca cacagtgata ttgatttgct ggttacggtg      480

accgtaaggc ttgatgaaac aacgcggcga gctttgatca acgacctttt ggaaacttcg      540

gcttcccctg gagagagcga gattctccgc gctgtagaag tcaccattgt tgtgcacgac      600

gacatcattc cgtggcgtta tccagctaag cgcgaactgc aatttggaga atggcagcgc      660

aatgacattc ttgcaggtat cttcgagcca gccacgatcg acattgatct ggctatcttg      720

ctgacaaaag caagagaaca tagcgttgcc ttggtaggtc cagcggcgga ggaactcttt      780

gatccggttc ctgaacagga tctatttgag gcgctaaatg aaaccttaac gctatggaac      840

tcgccgcccg actgggctgg cgatgagcga aatgtagtgc ttacgttgtc ccgcatttgg      900

tacagcgcag taaccggcaa aatcgcgccg aaggatgtcg ctgccgactg ggcaatggag      960

cgcctgccgg cccagtatca gcccgtcata cttgaagcta gacaggctta tcttggacaa     1020

gaagaagatc gcttggcctc gcgcgcagat cagttggaag aatttgtcca ctacgtgaaa     1080

ggcgagatca ccaaggtagt cggcaaataa tgtctaacaa ttcgttcaag ccgacggatc     1140

tatgtcgggt gcggagaaag aggtaatgaa atggcaccta ggtatcgata atacgactca     1200

ctatagggga attgtgagcg gataacaatt cccctctaga aataattttg tttaacttta     1260

agaaggagat atacatatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat     1320

cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga     1380

gggcgatgcc acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc     1440

cgtgccctgg cccaccctcg tgaccaccct gacctggggc gtgcagtgct tcagccgcta     1500

ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca     1560

ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt     1620

cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg     1680

caacatcctg gggcacaagc tggagtacaa ctacatcagc cacaacgtct atatcaccgc     1740

cgacaagcag aagaacggca tcaaggccaa cttcaagatc cgccacaaca tcgaggacgg     1800

cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct     1860

gctgcccgac aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa     1920

gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga     1980

cgagctgtac aagtccggac tcagatctcg acgagctcac gctagcatgg agtcggttgc     2040

tgcagagagc gctccagctc cggagaatga acactctcaa gagaccccgg aatcgaacag     2100

tagtgtgtac accaccttca tgaagtctca tcgctgctat gacctgatcc ccacaagctc     2160

caagctggtg gtatttgata cttcgctgca ggtaaagaaa gccttctttg ccctggtgac     2220

taacggtgtt cgtgctgccc ctttgtggga tagtaagaag cagagctttg tgggcatgct     2280

gaccatcact gacttcatca atattctgca ccgatactac aagtcagccc tggtgcagat     2340

ctatgaactg gaggagcaca agatagagac ttggagagag gtctacctgc aagactcctt     2400

taagccactt gtctgcattt ctccaaatgc cagcttgttc gatgctgtct cttcattaat     2460

tcgaaataag atccacaggc ttccagttat tgacccggag tcaggcaaca ccttgtacat     2520

tcttactcac aagcggatcc tcaagttcct caagttgttt atcactgagt tccccaagcc     2580

ggaattcatg tctaagtctc tggaagagct acagattggc acctacgcca atattgccat     2640

ggtccgtacc actacacctg tctatgtggc tctgggcatc tttgtacagc accgagtctc     2700

cgccttgcct gtggtggatg agaaagggcg tgtggtggac atctactcca agtttgatgt     2760

gattaatttg gcagcagaaa agacatacaa caacctagat gtgtctgtga caaaagccct     2820

acagcaccgg tcacactact tcgagggtgt tctcaagtgc tacctacatg agactctaga     2880

agcaatcatc aatagactgg tggaagcaga ggttcaccgt ctggtggtgg tggatgaaca     2940

tgacgtggtc aagggcattg tatcgctgtc tgacatctta caggctctgg tgctcacagg     3000

tggagagaag aagccctgat aactagttcc gtttaaaccc atgtgcctgg cagataactt     3060

cgtataatgt atgctatacg aagttatggt acgtactaag ctctcatgtt tcacgtacta     3120

agctctcatg tttaacgtac taagctctca tgtttaacga actaaaccct catggctaac     3180

gtactaagct ctcatggcta acgtactaag ctctcatgtt tcacgtacta agctctcatg     3240

tttgaacaat aaaattaata taaatcagca acttaaatag cctctaaggt tttaagtttt     3300

ataagaaaaa aaagaatata taaggctttt aaagctttta aggtttaacg gttgtggaca     3360

acaagccagg gatgtaacgc actgagaagc ccttagagcc tctcaaagca attttgagtg     3420

acacaggaac acttaacggc tgacataatt cagcttcacg ctgccgcaag cactcagggc     3480

gcaagggctg ctaaaggaag cggaacacgt agaaagccag tccgcagaaa cggtgctgac     3540

cccggatgaa tgtcagctgg gaggcagaat aaatgatcat atcgtcaat                 3589


<210>  45
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat eCFP-gamma1, T7 promoter

<400>  45

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser 
225                 230                 235                 240 


Gly Leu Arg Ser Arg Arg Ala His Ala Ser Met Glu Ser Val Ala Ala 
                245                 250                 255     


Glu Ser Ala Pro Ala Pro Glu Asn Glu His Ser Gln Glu Thr Pro Glu 
            260                 265                 270         


Ser Asn Ser Ser Val Tyr Thr Thr Phe Met Lys Ser His Arg Cys Tyr 
        275                 280                 285             


Asp Leu Ile Pro Thr Ser Ser Lys Leu Val Val Phe Asp Thr Ser Leu 
    290                 295                 300                 


Gln Val Lys Lys Ala Phe Phe Ala Leu Val Thr Asn Gly Val Arg Ala 
305                 310                 315                 320 


Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser Phe Val Gly Met Leu Thr 
                325                 330                 335     


Ile Thr Asp Phe Ile Asn Ile Leu His Arg Tyr Tyr Lys Ser Ala Leu 
            340                 345                 350         


Val Gln Ile Tyr Glu Leu Glu Glu His Lys Ile Glu Thr Trp Arg Glu 
        355                 360                 365             


Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu Val Cys Ile Ser Pro Asn 
    370                 375                 380                 


Ala Ser Leu Phe Asp Ala Val Ser Ser Leu Ile Arg Asn Lys Ile His 
385                 390                 395                 400 


Arg Leu Pro Val Ile Asp Pro Glu Ser Gly Asn Thr Leu Tyr Ile Leu 
                405                 410                 415     


Thr His Lys Arg Ile Leu Lys Phe Leu Lys Leu Phe Ile Thr Glu Phe 
            420                 425                 430         


Pro Lys Pro Glu Phe Met Ser Lys Ser Leu Glu Glu Leu Gln Ile Gly 
        435                 440                 445             


Thr Tyr Ala Asn Ile Ala Met Val Arg Thr Thr Thr Pro Val Tyr Val 
    450                 455                 460                 


Ala Leu Gly Ile Phe Val Gln His Arg Val Ser Ala Leu Pro Val Val 
465                 470                 475                 480 


Asp Glu Lys Gly Arg Val Val Asp Ile Tyr Ser Lys Phe Asp Val Ile 
                485                 490                 495     


Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn Leu Asp Val Ser Val Thr 
            500                 505                 510         


Lys Ala Leu Gln His Arg Ser His Tyr Phe Glu Gly Val Leu Lys Cys 
        515                 520                 525             


Tyr Leu His Glu Thr Leu Glu Ala Ile Ile Asn Arg Leu Val Glu Ala 
    530                 535                 540                 


Glu Val His Arg Leu Val Val Val Asp Glu His Asp Val Val Lys Gly 
545                 550                 555                 560 


Ile Val Ser Leu Ser Asp Ile Leu Gln Ala Leu Val Leu Thr Gly Gly 
                565                 570                 575     


Glu Lys Lys Pro 
            580 


<210>  46
<211>  3640
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-YFP, pDS plasmid, T7 promoter

<400>  46
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga taatacgact cactataggg gaattgtgag      900

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat      960

ggagtcggtt gctgcagaga gcgctccagc tccggagaat gaacactctc aagagacccc     1020

ggaatcgaac agtagtgtgt acaccacctt catgaagtct catcgctgct atgacctgat     1080

ccccacaagc tccaagctgg tggtatttga tacttcgctg caggtaaaga aagccttctt     1140

tgccctggtg actaacggtg ttcgtgctgc ccctttgtgg gatagtaaga agcagagctt     1200

tgtgggcatg ctgaccatca ctgacttcat caatattctg caccgatact acaagtcagc     1260

cctggtgcag atctatgaac tggaggagca caagatagag acttggagag aggtctacct     1320

gcaagactcc tttaagccac ttgtctgcat ttctccaaat gccagcttgt tcgatgctgt     1380

ctcttcatta attcgaaata agatccacag gcttccagtt attgacccgg agtcaggcaa     1440

caccttgtac attcttactc acaagcggat cctcaagttc ctcaagttgt ttatcactga     1500

gttccccaag ccggaattca tgtctaagtc tctggaagag ctacagattg gcacctacgc     1560

caatattgcc atggtccgta ccactacacc tgtctatgtg gctctgggca tctttgtaca     1620

gcaccgagtc tccgccttgc ctgtggtgga tgagaaaggg cgtgtggtgg acatctactc     1680

caagtttgat gtgattaatt tggcagcaga aaagacatac aacaacctag atgtgtctgt     1740

gacaaaagcc ctacagcacc ggtcacacta cttcgagggt gttctcaagt gctacctaca     1800

tgagactcta gaagcaatca tcaatagact ggtggaagca gaggttcacc gtctggtggt     1860

ggtggatgaa catgacgtgg tcaagggcat tgtatcgctg tctgacatct tacaggctct     1920

ggtgctcaca ggtggagaga agaagcccgc tagcatggtg agcaagggcg aggagctgtt     1980

caccggggtg gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag     2040

cgtgtccggc gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg     2100

caccaccggc aagctgcccg tgccctggcc caccctcgtg accaccttcg gctacggcct     2160

gcagtgcttc gcccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat     2220

gcccgaaggc tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac     2280

ccgcgccgag gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat     2340

cgacttcaag gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca     2400

caacgtctat atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg     2460

ccacaacatc gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat     2520

cggcgacggc cccgtgctgc tgcccgacaa ccactacctg agctaccagt ccgccctgag     2580

caaagacccc aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg     2640

gatcactctc ggcatggacg agctgtacaa gtccggactc agatctcgag ctcaagcttc     2700

gaattctgca gtcgacggta ccgcgggccc gggatccacc ggatctagat gataactagt     2760

tccgtttaaa cccatgtgcc tggcagataa cttcgtataa tgtatgctat acgaagttat     2820

ggtacgtact aagctctcat gtttcacgta ctaagctctc atgtttaacg tactaagctc     2880

tcatgtttaa cgaactaaac cctcatggct aacgtactaa gctctcatgg ctaacgtact     2940

aagctctcat gtttcacgta ctaagctctc atgtttgaac aataaaatta atataaatca     3000

gcaacttaaa tagcctctaa ggttttaagt tttataagaa aaaaaagaat atataaggct     3060

tttaaagctt ttaaggttta acggttgtgg acaacaagcc agggatgtaa cgcactgaga     3120

agcccttaga gcctctcaaa gcaattttga gtgacacagg aacacttaac ggctgacata     3180

attcagcttc acgctgccgc aagcactcag ggcgcaaggg ctgctaaagg aagcggaaca     3240

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tgggaggcag     3300

aataaatgat catatcgtca attattacct ccacggggag agcctgagca aactggcctc     3360

aggcatttga gaagcacacg gtcacactgc ttccggtagt caataaaccg gtaagtagcg     3420

tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta acggcgcagt     3480

ggcggttttc atggcttgtt atgactgttt ttttggggta cagtctatgc ctcgggcatc     3540

caagcagcaa gcgcgttacg ccgtgggtcg atgtttgatg ttatggagca gcaacgatgt     3600

tacgcagcag ggcagtcgcc ctaaaacaaa gttaaacatc                           3640


<210>  47
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-YFP, T7 promoter

<400>  47

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro Ala Ser Met Val Ser Lys 
                325                 330                 335     


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
            340                 345                 350         


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
        355                 360                 365             


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
    370                 375                 380                 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly 
385                 390                 395                 400 


Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
                405                 410                 415     


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
            420                 425                 430         


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
        435                 440                 445             


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
    450                 455                 460                 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser 
465                 470                 475                 480 


His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val 
                485                 490                 495     


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
            500                 505                 510         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        515                 520                 525             


Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro 
    530                 535                 540                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
545                 550                 555                 560 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser 
                565                 570                 575     


Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr Ala Gly Pro Gly 
            580                 585                 590         


Ser Thr Gly Ser Arg 
        595         


<210>  48
<211>  3640
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat YFP-gamma1, pDS plasmid, T7 promoter

<400>  48
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga taatacgact cactataggg gaattgtgag      900

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat      960

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     1020

cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     1080

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     1140

cgtgaccacc ttcggctacg gcctgcagtg cttcgcccgc taccccgacc acatgaagca     1200

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt     1260

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     1320

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     1380

gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg     1440

catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga     1500

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     1560

cctgagctac cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     1620

gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtccgg     1680

actcagatct cgagctcaag cttcgaattc tgcagtcgac ggtaccgcgg gcccgggatc     1740

caccggatct agagctagca tggagtcggt tgctgcagag agcgctccag ctccggagaa     1800

tgaacactct caagagaccc cggaatcgaa cagtagtgtg tacaccacct tcatgaagtc     1860

tcatcgctgc tatgacctga tccccacaag ctccaagctg gtggtatttg atacttcgct     1920

gcaggtaaag aaagccttct ttgccctggt gactaacggt gttcgtgctg cccctttgtg     1980

ggatagtaag aagcagagct ttgtgggcat gctgaccatc actgacttca tcaatattct     2040

gcaccgatac tacaagtcag ccctggtgca gatctatgaa ctggaggagc acaagataga     2100

gacttggaga gaggtctacc tgcaagactc ctttaagcca cttgtctgca tttctccaaa     2160

tgccagcttg ttcgatgctg tctcttcatt aattcgaaat aagatccaca ggcttccagt     2220

tattgacccg gagtcaggca acaccttgta cattcttact cacaagcgga tcctcaagtt     2280

cctcaagttg tttatcactg agttccccaa gccggaattc atgtctaagt ctctggaaga     2340

gctacagatt ggcacctacg ccaatattgc catggtccgt accactacac ctgtctatgt     2400

ggctctgggc atctttgtac agcaccgagt ctccgccttg cctgtggtgg atgagaaagg     2460

gcgtgtggtg gacatctact ccaagtttga tgtgattaat ttggcagcag aaaagacata     2520

caacaaccta gatgtgtctg tgacaaaagc cctacagcac cggtcacact acttcgaggg     2580

tgttctcaag tgctacctac atgagactct agaagcaatc atcaatagac tggtggaagc     2640

agaggttcac cgtctggtgg tggtggatga acatgacgtg gtcaagggca ttgtatcgct     2700

gtctgacatc ttacaggctc tggtgctcac aggtggagag aagaagccct gataactagt     2760

tccgtttaaa cccatgtgcc tggcagataa cttcgtataa tgtatgctat acgaagttat     2820

ggtacgtact aagctctcat gtttcacgta ctaagctctc atgtttaacg tactaagctc     2880

tcatgtttaa cgaactaaac cctcatggct aacgtactaa gctctcatgg ctaacgtact     2940

aagctctcat gtttcacgta ctaagctctc atgtttgaac aataaaatta atataaatca     3000

gcaacttaaa tagcctctaa ggttttaagt tttataagaa aaaaaagaat atataaggct     3060

tttaaagctt ttaaggttta acggttgtgg acaacaagcc agggatgtaa cgcactgaga     3120

agcccttaga gcctctcaaa gcaattttga gtgacacagg aacacttaac ggctgacata     3180

attcagcttc acgctgccgc aagcactcag ggcgcaaggg ctgctaaagg aagcggaaca     3240

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tgggaggcag     3300

aataaatgat catatcgtca attattacct ccacggggag agcctgagca aactggcctc     3360

aggcatttga gaagcacacg gtcacactgc ttccggtagt caataaaccg gtaagtagcg     3420

tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta acggcgcagt     3480

ggcggttttc atggcttgtt atgactgttt ttttggggta cagtctatgc ctcgggcatc     3540

caagcagcaa gcgcgttacg ccgtgggtcg atgtttgatg ttatggagca gcaacgatgt     3600

tacgcagcag ggcagtcgcc ctaaaacaaa gttaaacatc                           3640


<210>  49
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat YFP-gamma1

<400>  49

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser 
225                 230                 235                 240 


Gly Leu Arg Ser Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr 
                245                 250                 255     


Ala Gly Pro Gly Ser Thr Gly Ser Arg Ala Ser Met Glu Ser Val Ala 
            260                 265                 270         


Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His Ser Gln Glu Thr Pro 
        275                 280                 285             


Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met Lys Ser His Arg Cys 
    290                 295                 300                 


Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val Val Phe Asp Thr Ser 
305                 310                 315                 320 


Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val Thr Asn Gly Val Arg 
                325                 330                 335     


Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser Phe Val Gly Met Leu 
            340                 345                 350         


Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg Tyr Tyr Lys Ser Ala 
        355                 360                 365             


Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys Ile Glu Thr Trp Arg 
    370                 375                 380                 


Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu Val Cys Ile Ser Pro 
385                 390                 395                 400 


Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu Ile Arg Asn Lys Ile 
                405                 410                 415     


His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly Asn Thr Leu Tyr Ile 
            420                 425                 430         


Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys Leu Phe Ile Thr Glu 
        435                 440                 445             


Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu Glu Glu Leu Gln Ile 
    450                 455                 460                 


Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr Thr Thr Pro Val Tyr 
465                 470                 475                 480 


Val Ala Leu Gly Ile Phe Val Gln His Arg Val Ser Ala Leu Pro Val 
                485                 490                 495     


Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr Ser Lys Phe Asp Val 
            500                 505                 510         


Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn Leu Asp Val Ser Val 
        515                 520                 525             


Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe Glu Gly Val Leu Lys 
    530                 535                 540                 


Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile Asn Arg Leu Val Glu 
545                 550                 555                 560 


Ala Glu Val His Arg Leu Val Val Val Asp Glu His Asp Val Val Lys 
                565                 570                 575     


Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala Leu Val Leu Thr Gly 
            580                 585                 590         


Gly Glu Lys Lys Pro 
        595         


<210>  50
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  eYFP

<400>  50
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccttcggcta cggcctgcag tgcttcgccc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagct accagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtcc      720

ggactcagat ctcgagctca agcttcgaat tctgcagtcg acggtaccgc gggcccggga      780

tccaccggat ctaga                                                       795


<210>  51
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  eYFP

<400>  51

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser 
225                 230                 235                 240 


Gly Leu Arg Ser Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr 
                245                 250                 255     


Ala Gly Pro Gly Ser Thr Gly Ser Arg 
            260                 265 


<210>  52
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  eYFP

<400>  52
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacag gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgacctg gggcgtgcag tgcttcgccc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg taccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacat cagccacaac gtctatatca ccgccgacaa gcagaagaac      480

ggcatcaagg cccacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccaa gctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgcctaa                                          687


<210>  53
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  eCFP

<400>  53

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Arg Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala His Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala 
225             


<210>  54
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpVenus

<400>  54
atgggcggcg tgcagctcgc cgaccactac cagcagaaca cccccatcgg cgacggcccc       60

gtgctgctgc ccgacaacca ctacctgagc taccagtcca agctgagcaa agaccccaac      120

gagaagcgcg atcacatggt cctgctggag ttcgtgaccg ccgccgggat cactctcggc      180

atggacgagc tgtacaaggg tggcagcggt ggcatggtga gcaagggcga ggagctgttc      240

accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc      300

gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gctgatctgc      360

accaccggca agctgcccgt gccctggccc accctcgtga ccaccctggg ctacggcctg      420

cagtgcttcg cccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg      480

cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc      540

cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc      600

gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac      660

aacgtctata tcaccgccga caagcagaag aacggcatca aggccaactt caagatccgc      720

cacaacatcg agtaatga                                                    738


<210>  55
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpVenus

<400>  55

Met Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
1               5                   10                  15      


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln 
            20                  25                  30          


Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
        35                  40                  45              


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
    50                  55                  60                  


Tyr Lys Gly Gly Ser Gly Gly Met Val Ser Lys Gly Glu Glu Leu Phe 
65                  70                  75                  80  


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
                85                  90                  95      


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
            100                 105                 110         


Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
        115                 120                 125             


Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala 
    130                 135                 140                 


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
145                 150                 155                 160 


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
                165                 170                 175     


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
            180                 185                 190         


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
        195                 200                 205             


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
    210                 215                 220                 


Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg 
225                 230                 235                 240 


His Asn Ile Glu 
                


<210>  56
<211>  3445
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human beta2-cpVenus, pDC plasmid

<400>  56
cgccccgccc tgccactcat cgcagtactg ttgtaattca ttaagcattc tgccgacatg       60

gaagccatca caaacggcat gatgaacctg aatcgccagc ggcatcagca ccttgtcgcc      120

ttgcgtataa tatttgccca tggtgaaaac gggggcgaag aagttgtcca tattggccac      180

gtttaaatca aaactggtga aactcaccca gggattggct gagacgaaaa acatattctc      240

aataaaccct ttagggaaat aggccaggtt ttcaccgtaa cacgccacat cttgcgaata      300

tatgtgtaga aactgccgga aatcgtcgtg gtattcactc cagagcgatg aaaacgtttc      360

agtttgctca tggaaaacgg tgtaacaagg gtgaacacta tcccatatca ccagctcacc      420

gtctttcatt gccatacgga attccggatg agcattcatc aggcgggcaa gaatgtgaat      480

aaaggccgga taaaacttgt gcttattttt ctttacggtc tttaaaaagg ccgtaatatc      540

cagctgaacg gtctggttat aggtacattg agcaactgac tgaaatgcct caaaatgttc      600

tttacgatgc cattgggata tatcaacggt ggtatatcca gtgatttttt tctccatttt      660

agcttcctta gctcctgaaa atctcgataa ctcaaaaaat acgcccggta gtgatcttat      720

ttcattatgg tgaaagttgg accctcttac gtgccgatca acgtctcatt ttcgccaaaa      780

gttggcccag atcaacgtct cattttcgcc aaaagttggc ccagatctat gtcgggtgcg      840

gagaaagagg taatgaaatg gcacctaggt atcgataata cgactcacta taggggaatt      900

gtgagcggat aacaattccc ctctagaaat aattttgttt aactttaaga aggagatata      960

catatgaggc ctatgggaaa caccaccagc gaccgggtgt ccggggagcg ccacggcgcc     1020

aaggctgcac gctccgaggg cgcaggcggc catgccccgg ggaaggagca caagatcatg     1080

gtggggagta cggacgaccc cagcgtgttc agcctccctg actccaagct ccctggggac     1140

aaagagtttg tatcatggca gcaggatttg gaggactccg taaagcccac acagcaggcc     1200

cggcccactg ttatccgctg gtctgaagga ggcaaggagg tcttcatctc tgggtccttc     1260

aacaattgga gcgccaagat tccactgatt aagagccata atgactttgt tgccatcctg     1320

gacctccctg agggagagca ccaatacaag ttctttgtgg atggacagtg ggttcatgat     1380

ccatcagagc ctgtggttac cagtcagctt ggcacaatta acaatttgat ccatgtcaag     1440

aaatctgatt ttgaggtgtt cgatgcttta aagttagatt ctatggaaag ttctgagaca     1500

tcttgtagag acctttccag ctcaccccca gggccttatg gtcaagaaat gtatgcgttt     1560

cgatctgagg aaagattcaa atccccaccc atccttcctc ctcatctact tcaagttatt     1620

cttaacaaag acactaatat ttcttgtgac ccagccttac tccctgagcc caaccatgtt     1680

atgctgaacc atctctatgc attgtccatt aaggacagtg tgatggtcct tagcgcaacc     1740

catcgctaca agaagaagta tgttactact ctgctataca agcccattgt gcacatgggc     1800

ggcgtgcagc tcgccgacca ctaccagcag aacaccccca tcggcgacgg ccccgtgctg     1860

ctgcccgaca accactacct gagctaccag tccaagctga gcaaagaccc caacgagaag     1920

cgcgatcaca tggtcctgct ggagttcgtg accgccgccg ggatcactct cggcatggac     1980

gagctgtaca agggtggcag cggtggcatg gtgagcaagg gcgaggagct gttcaccggg     2040

gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt cagcgtgtcc     2100

ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagctgat ctgcaccacc     2160

ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgggctacgg cctgcagtgc     2220

ttcgcccgct accccgacca catgaagcag cacgacttct tcaagtccgc catgcccgaa     2280

ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa gacccgcgcc     2340

gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg catcgacttc     2400

aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag ccacaacgtc     2460

tatatcaccg ccgacaagca gaagaacggc atcaaggcca acttcaagat ccgccacaac     2520

atcgagtaat gagcatgcta gcataacccc ttggggcctc taaacgggtc ttgaggggtt     2580

ttttggttta aacccatgtg cctggcagat aacttcgtat aatgtatgct atacgaagtt     2640

atggtaccgc ggccgcgtag aggatctgtt gatcagcagt tcaacctgtt gatagtacgt     2700

actaagctct catgtttcac gtactaagct ctcatgttta acgtactaag ctctcatgtt     2760

taacgaacta aaccctcatg gctaacgtac taagctctca tggctaacgt actaagctct     2820

catgtttcac gtactaagct ctcatgtttg aacaataaaa ttaatataaa tcagcaactt     2880

aaatagcctc taaggtttta agttttataa gaaaaaaaag aatatataag gcttttaaag     2940

cttttaaggt ttaacggttg tggacaacaa gccagggatg taacgcactg agaagccctt     3000

agagcctctc aaagcaattt tgagtgacac aggaacactt aacggctgac agaattagct     3060

tcacgctgcc gcaagcactc agggcgcaag ggctgctaaa ggaagcggaa cacgtagaaa     3120

gccagtccgc agaaacggtg ctgaccccgg atgaatgtca gctgggaggc agaataaatg     3180

atcatatcgt caattattac ctccacgggg agagcctgag caaactggcc tcaggcattt     3240

gagaagcaca cggtcacact gcttccggta gtcaataaac cggtaaacca gcaatagaca     3300

taagcggcta tttaacgacc ctgccctgaa ccgacgaccg ggtcgaattt gctttcgaat     3360

ttctgccatt catccgctta ttatcactta ttcaggcgta gcaaccaggc gtttaagggc     3420

accaataact gccttaaaaa aatta                                           3445


<210>  57
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human beta2-cpVenus

<400>  57

Met Gly Asn Thr Thr Ser Asp Arg Val Ser Gly Glu Arg His Gly Ala 
1               5                   10                  15      


Lys Ala Ala Arg Ser Glu Gly Ala Gly Gly His Ala Pro Gly Lys Glu 
            20                  25                  30          


His Lys Ile Met Val Gly Ser Thr Asp Asp Pro Ser Val Phe Ser Leu 
        35                  40                  45              


Pro Asp Ser Lys Leu Pro Gly Asp Lys Glu Phe Val Ser Trp Gln Gln 
    50                  55                  60                  


Asp Leu Glu Asp Ser Val Lys Pro Thr Gln Gln Ala Arg Pro Thr Val 
65                  70                  75                  80  


Ile Arg Trp Ser Glu Gly Gly Lys Glu Val Phe Ile Ser Gly Ser Phe 
                85                  90                  95      


Asn Asn Trp Ser Ala Lys Ile Pro Leu Ile Lys Ser His Asn Asp Phe 
            100                 105                 110         


Val Ala Ile Leu Asp Leu Pro Glu Gly Glu His Gln Tyr Lys Phe Phe 
        115                 120                 125             


Val Asp Gly Gln Trp Val His Asp Pro Ser Glu Pro Val Val Thr Ser 
    130                 135                 140                 


Gln Leu Gly Thr Ile Asn Asn Leu Ile His Val Lys Lys Ser Asp Phe 
145                 150                 155                 160 


Glu Val Phe Asp Ala Leu Lys Leu Asp Ser Met Glu Ser Ser Glu Thr 
                165                 170                 175     


Ser Cys Arg Asp Leu Ser Ser Ser Pro Pro Gly Pro Tyr Gly Gln Glu 
            180                 185                 190         


Met Tyr Ala Phe Arg Ser Glu Glu Arg Phe Lys Ser Pro Pro Ile Leu 
        195                 200                 205             


Pro Pro His Leu Leu Gln Val Ile Leu Asn Lys Asp Thr Asn Ile Ser 
    210                 215                 220                 


Cys Asp Pro Ala Leu Leu Pro Glu Pro Asn His Val Met Leu Asn His 
225                 230                 235                 240 


Leu Tyr Ala Leu Ser Ile Lys Asp Ser Val Met Val Leu Ser Ala Thr 
                245                 250                 255     


His Arg Tyr Lys Lys Lys Tyr Val Thr Thr Leu Leu Tyr Lys Pro Ile 
            260                 265                 270         


Val His Met Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
        275                 280                 285             


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
    290                 295                 300                 


Tyr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
305                 310                 315                 320 


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp 
                325                 330                 335     


Glu Leu Tyr Lys Gly Gly Ser Gly Gly Met Val Ser Lys Gly Glu Glu 
            340                 345                 350         


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
        355                 360                 365             


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
    370                 375                 380                 


Tyr Gly Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro 
385                 390                 395                 400 


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys 
                405                 410                 415     


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
            420                 425                 430         


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
        435                 440                 445             


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
    450                 455                 460                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
465                 470                 475                 480 


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
                485                 490                 495     


Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys 
            500                 505                 510         


Ile Arg His Asn Ile Glu 
        515             


<210>  58
<211>  3536
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human cpVenus-beta2, pDC plasmid

<400>  58
cgccaaaagt tggcccagat caacgtctca ttttcgccaa aagttggccc agatctatgt       60

cgggtgcgga gaaagaggta atgaaatggc acctaggtat cgataatacg actcactata      120

ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa ctttaagaag      180

gagatataca tatgggcggc gtgcagctcg ccgaccacta ccagcagaac acccccatcg      240

gcgacggccc cgtgctgctg cccgacaacc actacctgag ctaccagtcc aagctgagca      300

aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga      360

tcactctcgg catggacgag ctgtacaagg gtggcagcgg tggcatggtg agcaagggcg      420

aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc      480

acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag ctgaccctga      540

agctgatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg accaccctgg      600

gctacggcct gcagtgcttc gcccgctacc ccgaccacat gaagcagcac gacttcttca      660

agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag gacgacggca      720

actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac cgcatcgagc      780

tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg gagtacaact      840

acaacagcca caacgtctat atcaccgccg acaagcagaa gaacggcatc aaggccaact      900

tcaagatccg ccacaacatc gagaggccta tgggaaacac caccagcgac cgggtgtccg      960

gggagcgcca cggcgccaag gctgcacgct ccgagggcgc aggcggccat gccccgggga     1020

aggagcacaa gatcatggtg gggagtacgg acgaccccag cgtgttcagc ctccctgact     1080

ccaagctccc tggggacaaa gagtttgtat catggcagca ggatttggag gactccgtaa     1140

agcccacaca gcaggcccgg cccactgtta tccgctggtc tgaaggaggc aaggaggtct     1200

tcatctctgg gtccttcaac aattggagcg ccaagattcc actgattaag agccataatg     1260

actttgttgc catcctggac ctccctgagg gagagcacca atacaagttc tttgtggatg     1320

gacagtgggt tcatgatcca tcagagcctg tggttaccag tcagcttggc acaattaaca     1380

atttgatcca tgtcaagaaa tctgattttg aggtgttcga tgctttaaag ttagattcta     1440

tggaaagttc tgagacatct tgtagagacc tttccagctc acccccaggg ccttatggtc     1500

aagaaatgta tgcgtttcga tctgaggaaa gattcaaatc cccacccatc cttcctcctc     1560

atctacttca agttattctt aacaaagaca ctaatatttc ttgtgaccca gccttactcc     1620

ctgagcccaa ccatgttatg ctgaaccatc tctatgcatt gtccattaag gacagtgtga     1680

tggtccttag cgcaacccat cgctacaaga agaagtatgt tactactctg ctatacaagc     1740

ccattgtgca ctaagcatgc tagcataacc ccttggggcc tctaaacggg tcttgagggg     1800

ttttttggtt taaacccatg tgcctggcag ataacttcgt ataatgtatg ctatacgaag     1860

ttatggtacc gcggccgcgt agaggatctg ttgatcagca gttcaacctg ttgatagtac     1920

gtactaagct ctcatgtttc acgtactaag ctctcatgtt taacgtacta agctctcatg     1980

tttaacgaac taaaccctca tggctaacgt actaagctct catggctaac gtactaagct     2040

ctcatgtttc acgtactaag ctctcatgtt tgaacaataa aattaatata aatcagcaac     2100

ttaaatagcc tctaaggttt taagttttat aagaaaaaaa agaatatata aggcttttaa     2160

agcttttaag gtttaacggt tgtggacaac aagccaggga tgtaacgcac tgagaagccc     2220

ttagagcctc tcaaagcaat tttgagtgac acaggaacac ttaacggctg acagaattag     2280

cttcacgctg ccgcaagcac tcagggcgca agggctgcta aaggaagcgg aacacgtaga     2340

aagccagtcc gcagaaacgg tgctgacccc ggatgaatgt cagctgggag gcagaataaa     2400

tgatcatatc gtcaattatt acctccacgg ggagagcctg agcaaactgg cctcaggcat     2460

ttgagaagca cacggtcaca ctgcttccgg tagtcaataa accggtaaac cagcaataga     2520

cataagcggc tatttaacga ccctgccctg aaccgacgac cgggtcgaat ttgctttcga     2580

atttctgcca ttcatccgct tattatcact tattcaggcg tagcaaccag gcgtttaagg     2640

gcaccaataa ctgccttaaa aaaattacgc cccgccctgc cactcatcgc agtactgttg     2700

taattcatta agcattctgc cgacatggaa gccatcacaa acggcatgat gaacctgaat     2760

cgccagcggc atcagcacct tgtcgccttg cgtataatat ttgcccatgg tgaaaacggg     2820

ggcgaagaag ttgtccatat tggccacgtt taaatcaaaa ctggtgaaac tcacccaggg     2880

attggctgag acgaaaaaca tattctcaat aaacccttta gggaaatagg ccaggttttc     2940

accgtaacac gccacatctt gcgaatatat gtgtagaaac tgccggaaat cgtcgtggta     3000

ttcactccag agcgatgaaa acgtttcagt ttgctcatgg aaaacggtgt aacaagggtg     3060

aacactatcc catatcacca gctcaccgtc tttcattgcc atacggaatt ccggatgagc     3120

attcatcagg cgggcaagaa tgtgaataaa ggccggataa aacttgtgct tatttttctt     3180

tacggtcttt aaaaaggccg taatatccag ctgaacggtc tggttatagg tacattgagc     3240

aactgactga aatgcctcaa aatgttcttt acgatgccat tgggatatat caacggtggt     3300

atatccagtg atttttttct ccattttagc ttccttagct cctgaaaatc tcgataactc     3360

aaaaaatacg cccggtagtg atcttatttc attatggtga aagttggacc ctcttacgtg     3420

ccgatcaacg tctcattttc gccaaaagtt ggcccagatc aacgtctcat tttcgccaaa     3480

agttggccca gatctatgtc gggtgcggag aaagaggtaa tgaaatggca cctagg         3536


<210>  59
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human cpVenus-beta2

<400>  59

Met Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
1               5                   10                  15      


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln 
            20                  25                  30          


Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
        35                  40                  45              


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
    50                  55                  60                  


Tyr Lys Gly Gly Ser Gly Gly Met Val Ser Lys Gly Glu Glu Leu Phe 
65                  70                  75                  80  


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
                85                  90                  95      


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
            100                 105                 110         


Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
        115                 120                 125             


Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala 
    130                 135                 140                 


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
145                 150                 155                 160 


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
                165                 170                 175     


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
            180                 185                 190         


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
        195                 200                 205             


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
    210                 215                 220                 


Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg 
225                 230                 235                 240 


His Asn Ile Glu Arg Pro Met Gly Asn Thr Thr Ser Asp Arg Val Ser 
                245                 250                 255     


Gly Glu Arg His Gly Ala Lys Ala Ala Arg Ser Glu Gly Ala Gly Gly 
            260                 265                 270         


His Ala Pro Gly Lys Glu His Lys Ile Met Val Gly Ser Thr Asp Asp 
        275                 280                 285             


Pro Ser Val Phe Ser Leu Pro Asp Ser Lys Leu Pro Gly Asp Lys Glu 
    290                 295                 300                 


Phe Val Ser Trp Gln Gln Asp Leu Glu Asp Ser Val Lys Pro Thr Gln 
305                 310                 315                 320 


Gln Ala Arg Pro Thr Val Ile Arg Trp Ser Glu Gly Gly Lys Glu Val 
                325                 330                 335     


Phe Ile Ser Gly Ser Phe Asn Asn Trp Ser Ala Lys Ile Pro Leu Ile 
            340                 345                 350         


Lys Ser His Asn Asp Phe Val Ala Ile Leu Asp Leu Pro Glu Gly Glu 
        355                 360                 365             


His Gln Tyr Lys Phe Phe Val Asp Gly Gln Trp Val His Asp Pro Ser 
    370                 375                 380                 


Glu Pro Val Val Thr Ser Gln Leu Gly Thr Ile Asn Asn Leu Ile His 
385                 390                 395                 400 


Val Lys Lys Ser Asp Phe Glu Val Phe Asp Ala Leu Lys Leu Asp Ser 
                405                 410                 415     


Met Glu Ser Ser Glu Thr Ser Cys Arg Asp Leu Ser Ser Ser Pro Pro 
            420                 425                 430         


Gly Pro Tyr Gly Gln Glu Met Tyr Ala Phe Arg Ser Glu Glu Arg Phe 
        435                 440                 445             


Lys Ser Pro Pro Ile Leu Pro Pro His Leu Leu Gln Val Ile Leu Asn 
    450                 455                 460                 


Lys Asp Thr Asn Ile Ser Cys Asp Pro Ala Leu Leu Pro Glu Pro Asn 
465                 470                 475                 480 


His Val Met Leu Asn His Leu Tyr Ala Leu Ser Ile Lys Asp Ser Val 
                485                 490                 495     


Met Val Leu Ser Ala Thr His Arg Tyr Lys Lys Lys Tyr Val Thr Thr 
            500                 505                 510         


Leu Leu Tyr Lys Pro Ile Val His 
        515                 520 


<210>  60
<211>  3569
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-cpVenus, pDS plasmid

<400>  60
tgtctaacaa ttcgttcaag ccgacggatc tatgtcgggt gcggagaaag aggtaatgaa       60

atggcaccta ggtatcgata atacgactca ctatagggga attgtgagcg gataacaatt      120

cccctctaga aataattttg tttaacttta agaaggagat atacatatgg agtcggttgc      180

tgcagagagc gctccagctc cggagaatga acactctcaa gagaccccgg aatcgaacag      240

tagtgtgtac accaccttca tgaagtctca tcgctgctat gacctgatcc ccacaagctc      300

caagctggtg gtatttgata cttcgctgca ggtaaagaaa gccttctttg ccctggtgac      360

taacggtgtt cgtgctgccc ctttgtggga tagtaagaag cagagctttg tgggcatgct      420

gaccatcact gacttcatca atattctgca ccgatactac aagtcagccc tggtgcagat      480

ctatgaactg gaggagcaca agatagagac ttggagagag gtctacctgc aagactcctt      540

taagccactt gtctgcattt ctccaaatgc cagcttgttc gatgctgtct cttcattaat      600

tcgaaataag atccacaggc ttccagttat tgacccggag tcaggcaaca ccttgtacat      660

tcttactcac aagcggatcc tcaagttcct caagttgttt atcactgagt tccccaagcc      720

ggaattcatg tctaagtctc tggaagagct acagattggc acctacgcca atattgccat      780

ggtccgtacc actacacctg tctatgtggc tctgggcatc tttgtacagc accgagtctc      840

cgccttgcct gtggtggatg agaaagggcg tgtggtggac atctactcca agtttgatgt      900

gattaatttg gcagcagaaa agacatacaa caacctagat gtgtctgtga caaaagccct      960

acagcaccgg tcacactact tcgagggtgt tctcaagtgc tacctacatg agactctaga     1020

agcaatcatc aatagactgg tggaagcaga ggttcaccgt ctggtggtgg tggatgaaca     1080

tgacgtggtc aagggcattg tatcgctgtc tgacatctta caggctctgg tgctcacagg     1140

tggagagaag aagcccgcta gcatgggcgg cgtgcagctc gccgaccact accagcagaa     1200

cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga gctaccagtc     1260

caagctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac     1320

cgccgccggg atcactctcg gcatggacga gctgtacaag ggtggcagcg gtggcatggt     1380

gagcaagggc gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga     1440

cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa     1500

gctgaccctg aagctgatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt     1560

gaccaccctg ggctacggcc tgcagtgctt cgcccgctac cccgaccaca tgaagcagca     1620

cgacttcttc aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa     1680

ggacgacggc aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa     1740

ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct     1800

ggagtacaac tacaacagcc acaacgtcta tatcaccgcc gacaagcaga agaacggcat     1860

caaggccaac ttcaagatcc gccacaacat cgagtaatag gtttaaaccc atgtgcctgg     1920

cagataactt cgtataatgt atgctatacg aagttatggt acgtactaag ctctcatgtt     1980

tcacgtacta agctctcatg tttaacgtac taagctctca tgtttaacga actaaaccct     2040

catggctaac gtactaagct ctcatggcta acgtactaag ctctcatgtt tcacgtacta     2100

agctctcatg tttgaacaat aaaattaata taaatcagca acttaaatag cctctaaggt     2160

tttaagtttt ataagaaaaa aaagaatata taaggctttt aaagctttta aggtttaacg     2220

gttgtggaca acaagccagg gatgtaacgc actgagaagc ccttagagcc tctcaaagca     2280

attttgagtg acacaggaac acttaacggc tgacataatt cagcttcacg ctgccgcaag     2340

cactcagggc gcaagggctg ctaaaggaag cggaacacgt agaaagccag tccgcagaaa     2400

cggtgctgac cccggatgaa tgtcagctgg gaggcagaat aaatgatcat atcgtcaatt     2460

attacctcca cggggagagc ctgagcaaac tggcctcagg catttgagaa gcacacggtc     2520

acactgcttc cggtagtcaa taaaccggta agtagcgtat gcgctcacgc aactggtcca     2580

gaaccttgac cgaacgcagc ggtggtaacg gcgcagtggc ggttttcatg gcttgttatg     2640

actgtttttt tggggtacag tctatgcctc gggcatccaa gcagcaagcg cgttacgccg     2700

tgggtcgatg tttgatgtta tggagcagca acgatgttac gcagcagggc agtcgcccta     2760

aaacaaagtt aaacatcatg agggaagcgg tgatcgccga agtatcgact caactatcag     2820

aggtagttgg cgtcatcgag cgccatctcg aaccgacgtt gctggccgta catttgtacg     2880

gctccgcagt ggatggcggc ctgaagccac acagtgatat tgatttgctg gttacggtga     2940

ccgtaaggct tgatgaaaca acgcggcgag ctttgatcaa cgaccttttg gaaacttcgg     3000

cttcccctgg agagagcgag attctccgcg ctgtagaagt caccattgtt gtgcacgacg     3060

acatcattcc gtggcgttat ccagctaagc gcgaactgca atttggagaa tggcagcgca     3120

atgacattct tgcaggtatc ttcgagccag ccacgatcga cattgatctg gctatcttgc     3180

tgacaaaagc aagagaacat agcgttgcct tggtaggtcc agcggcggag gaactctttg     3240

atccggttcc tgaacaggat ctatttgagg cgctaaatga aaccttaacg ctatggaact     3300

cgccgcccga ctgggctggc gatgagcgaa atgtagtgct tacgttgtcc cgcatttggt     3360

acagcgcagt aaccggcaaa atcgcgccga aggatgtcgc tgccgactgg gcaatggagc     3420

gcctgccggc ccagtatcag cccgtcatac ttgaagctag acaggcttat cttggacaag     3480

aagaagatcg cttggcctcg cgcgcagatc agttggaaga atttgtccac tacgtgaaag     3540

gcgagatcac caaggtagtc ggcaaataa                                       3569


<210>  61
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-cpVenus

<400>  61

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro Ala Ser Met Gly Gly Val 
                325                 330                 335     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            340                 345                 350         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Lys Leu Ser 
        355                 360                 365             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    370                 375                 380                 


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
                405                 410                 415     


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
            420                 425                 430         


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
        435                 440                 445             


Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
    450                 455                 460                 


Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp 
465                 470                 475                 480 


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
                485                 490                 495     


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
            500                 505                 510         


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
        515                 520                 525             


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
    530                 535                 540                 


Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys 
545                 550                 555                 560 


Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu 
                565                 570                 575     


<210>  62
<211>  3577
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat cpVenus-gamma1, pDS plasmid

<400>  62
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga taatacgact cactataggg gaattgtgag      900

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat      960

gggcggcgtg cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt     1020

gctgctgccc gacaaccact acctgagcta ccagtccaag ctgagcaaag accccaacga     1080

gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat     1140

ggacgagctg tacaagggtg gcagcggtgg catggtgagc aagggcgagg agctgttcac     1200

cggggtggtg cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt     1260

gtccggcgag ggcgagggcg atgccaccta cggcaagctg accctgaagc tgatctgcac     1320

caccggcaag ctgcccgtgc cctggcccac cctcgtgacc accctgggct acggcctgca     1380

gtgcttcgcc cgctaccccg accacatgaa gcagcacgac ttcttcaagt ccgccatgcc     1440

cgaaggctac gtccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg     1500

cgccgaggtg aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga     1560

cttcaaggag gacggcaaca tcctggggca caagctggag tacaactaca acagccacaa     1620

cgtctatatc accgccgaca agcagaagaa cggcatcaag gccaacttca agatccgcca     1680

caacatcgag gctagcatgg agtcggttgc tgcagagagc gctccagctc cggagaatga     1740

acactctcaa gagaccccgg aatcgaacag tagtgtgtac accaccttca tgaagtctca     1800

tcgctgctat gacctgatcc ccacaagctc caagctggtg gtatttgata cttcgctgca     1860

ggtaaagaaa gccttctttg ccctggtgac taacggtgtt cgtgctgccc ctttgtggga     1920

tagtaagaag cagagctttg tgggcatgct gaccatcact gacttcatca atattctgca     1980

ccgatactac aagtcagccc tggtgcagat ctatgaactg gaggagcaca agatagagac     2040

ttggagagag gtctacctgc aagactcctt taagccactt gtctgcattt ctccaaatgc     2100

cagcttgttc gatgctgtct cttcattaat tcgaaataag atccacaggc ttccagttat     2160

tgacccggag tcaggcaaca ccttgtacat tcttactcac aagcggatcc tcaagttcct     2220

caagttgttt atcactgagt tccccaagcc ggaattcatg tctaagtctc tggaagagct     2280

acagattggc acctacgcca atattgccat ggtccgtacc actacacctg tctatgtggc     2340

tctgggcatc tttgtacagc accgagtctc cgccttgcct gtggtggatg agaaagggcg     2400

tgtggtggac atctactcca agtttgatgt gattaatttg gcagcagaaa agacatacaa     2460

caacctagat gtgtctgtga caaaagccct acagcaccgg tcacactact tcgagggtgt     2520

tctcaagtgc tacctacatg agactctaga agcaatcatc aatagactgg tggaagcaga     2580

ggttcaccgt ctggtggtgg tggatgaaca tgacgtggtc aagggcattg tatcgctgtc     2640

tgacatctta caggctctgg tgctcacagg tggagagaag aagccctgat aactagttcc     2700

gtttaaaccc atgtgcctgg cagataactt cgtataatgt atgctatacg aagttatggt     2760

acgtactaag ctctcatgtt tcacgtacta agctctcatg tttaacgtac taagctctca     2820

tgtttaacga actaaaccct catggctaac gtactaagct ctcatggcta acgtactaag     2880

ctctcatgtt tcacgtacta agctctcatg tttgaacaat aaaattaata taaatcagca     2940

acttaaatag cctctaaggt tttaagtttt ataagaaaaa aaagaatata taaggctttt     3000

aaagctttta aggtttaacg gttgtggaca acaagccagg gatgtaacgc actgagaagc     3060

ccttagagcc tctcaaagca attttgagtg acacaggaac acttaacggc tgacataatt     3120

cagcttcacg ctgccgcaag cactcagggc gcaagggctg ctaaaggaag cggaacacgt     3180

agaaagccag tccgcagaaa cggtgctgac cccggatgaa tgtcagctgg gaggcagaat     3240

aaatgatcat atcgtcaatt attacctcca cggggagagc ctgagcaaac tggcctcagg     3300

catttgagaa gcacacggtc acactgcttc cggtagtcaa taaaccggta agtagcgtat     3360

gcgctcacgc aactggtcca gaaccttgac cgaacgcagc ggtggtaacg gcgcagtggc     3420

ggttttcatg gcttgttatg actgtttttt tggggtacag tctatgcctc gggcatccaa     3480

gcagcaagcg cgttacgccg tgggtcgatg tttgatgtta tggagcagca acgatgttac     3540

gcagcagggc agtcgcccta aaacaaagtt aaacatc                              3577


<210>  63
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat pVenus-gamma1

<400>  63

Met Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
1               5                   10                  15      


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln 
            20                  25                  30          


Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
        35                  40                  45              


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
    50                  55                  60                  


Tyr Lys Gly Gly Ser Gly Gly Met Val Ser Lys Gly Glu Glu Leu Phe 
65                  70                  75                  80  


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
                85                  90                  95      


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
            100                 105                 110         


Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
        115                 120                 125             


Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala 
    130                 135                 140                 


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
145                 150                 155                 160 


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
                165                 170                 175     


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
            180                 185                 190         


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
        195                 200                 205             


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
    210                 215                 220                 


Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg 
225                 230                 235                 240 


His Asn Ile Glu Ala Ser Met Glu Ser Val Ala Ala Glu Ser Ala Pro 
                245                 250                 255     


Ala Pro Glu Asn Glu His Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser 
            260                 265                 270         


Val Tyr Thr Thr Phe Met Lys Ser His Arg Cys Tyr Asp Leu Ile Pro 
        275                 280                 285             


Thr Ser Ser Lys Leu Val Val Phe Asp Thr Ser Leu Gln Val Lys Lys 
    290                 295                 300                 


Ala Phe Phe Ala Leu Val Thr Asn Gly Val Arg Ala Ala Pro Leu Trp 
305                 310                 315                 320 


Asp Ser Lys Lys Gln Ser Phe Val Gly Met Leu Thr Ile Thr Asp Phe 
                325                 330                 335     


Ile Asn Ile Leu His Arg Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr 
            340                 345                 350         


Glu Leu Glu Glu His Lys Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln 
        355                 360                 365             


Asp Ser Phe Lys Pro Leu Val Cys Ile Ser Pro Asn Ala Ser Leu Phe 
    370                 375                 380                 


Asp Ala Val Ser Ser Leu Ile Arg Asn Lys Ile His Arg Leu Pro Val 
385                 390                 395                 400 


Ile Asp Pro Glu Ser Gly Asn Thr Leu Tyr Ile Leu Thr His Lys Arg 
                405                 410                 415     


Ile Leu Lys Phe Leu Lys Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu 
            420                 425                 430         


Phe Met Ser Lys Ser Leu Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn 
        435                 440                 445             


Ile Ala Met Val Arg Thr Thr Thr Pro Val Tyr Val Ala Leu Gly Ile 
    450                 455                 460                 


Phe Val Gln His Arg Val Ser Ala Leu Pro Val Val Asp Glu Lys Gly 
465                 470                 475                 480 


Arg Val Val Asp Ile Tyr Ser Lys Phe Asp Val Ile Asn Leu Ala Ala 
                485                 490                 495     


Glu Lys Thr Tyr Asn Asn Leu Asp Val Ser Val Thr Lys Ala Leu Gln 
            500                 505                 510         


His Arg Ser His Tyr Phe Glu Gly Val Leu Lys Cys Tyr Leu His Glu 
        515                 520                 525             


Thr Leu Glu Ala Ile Ile Asn Arg Leu Val Glu Ala Glu Val His Arg 
    530                 535                 540                 


Leu Val Val Val Asp Glu His Asp Val Val Lys Gly Ile Val Ser Leu 
545                 550                 555                 560 


Ser Asp Ile Leu Gln Ala Leu Val Leu Thr Gly Gly Glu Lys Lys Pro 
                565                 570                 575     


<210>  64
<211>  4947
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat alpha2-mseCFP-11, pACE plasmid

<400>  64
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa      600

cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc      660

gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg      720

ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcctgat      780

gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcaatggtg cactctcagt      840

acaatctgct ctgatgccgc atagttaagc cagtatacac tccgctatcg ctacgtgact      900

gggtcatggc tgcgccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc      960

tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga     1020

ggttttcacc gtcatcaccg aaacgcgcga ggcaggggga attccagata acttcgtata     1080

atgtatgcta tacgaagtta tggtaccgcg gccgcgtaga ggatctgttg atcagcagtt     1140

caacctgttg atagtacttc gttaatacag atgtaggtgt tggcaccatg cataactata     1200

acggtcctaa ggtagcgacc taggtatcga taatacgact cactataggg gaattgtgag     1260

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atataatggg     1320

cagtagtcac catcaccacc accatcatca ccatcatagt agtgaaaacc tgtattttca     1380

ggggcatatg gctgagaagc agaagcacga cgggcgtgtg aagatcggac actacgtgct     1440

gggggacacc ctgggcgtcg gcaccttcgg caaagtgaag attggagaac atcaattgac     1500

aggccataaa gtggcagtta agatcttaaa tagacagaag attcgcagtt tagatgttgt     1560

tggaaaaata aaacgagaaa ttcaaaatct taaactcttt cgtcatcctc atattatcaa     1620

actctaccaa gtgatcagca ctccaacaga cttttttatg gtaatggaat atgtgtctgg     1680

aggtgaattg ttcgactaca tctgtaaaca cgggagggtt gaagaggtgg aagctcgccg     1740

gctcttccag cagattctgt ctgccgtgga ctactgtcac aggcacatgg ttgtccacag     1800

ggacctgaag ccagagaacg tgttgctgga cgcccagatg aatgctaaga tagctgactt     1860

cggactctct aatatgatgt cagatggtga atttctacga actagctgtg gatcgccaaa     1920

ttatgcagca ccggaggtca tctcaggaag gctgtatgcg ggtcctgagg ttgatatctg     1980

gagctgtggt gttatcctgt atgcccttct ctgtggcacc ctcccgttcg acgatgagca     2040

cgtgcctacg ctctttaaga agatccgagg gggtgtgttc tacatcccgg agtatctcaa     2100

ccgttctatt gccactctgc tgatgcacat gctgcaggtg gaccccttga agcgagcaac     2160

tatcaaagac atacgagagc atgaatggtt taaacaggat ttgcccagtt acctctttcc     2220

tgaagacccc tcctatgatg ctaacgtcat tgatgatgag gctgtgaaag aagtatgtga     2280

aaaatttgag tgtacagaat cagaagtgat gaacagttta tacagtggtg accctcaaga     2340

ccagctcgca gtggcttatc atctcatcat tgacaatcgg agaataatga accaagccag     2400

tgagttctac ctcgcctcca gtcctccaac gggttccttc atggacgata gtgccatgca     2460

tattcccccc ggcctgaaac cacatcctga aaggatgcca cctctcatag cagacagccc     2520

caaagcacgc tgtccactgg atgcactcaa cacaactaag cccaaatctt tagctgtgaa     2580

aaaagccaag tggcaccttg ggatccgaag ccagagcaaa ccatacgaca ttatggcgga     2640

ggtgtaccga gctatgaagc agctggactt tgaatggaag gtagtgaatg cataccatct     2700

tcgagtaaga agaaaaaacc cagtgactgg caattacgtg aaaatgagct tacagcttta     2760

cctggttgac aatcggagct atctgctgga ctttaaaagc atcgatgatg aggtggtgga     2820

gcagaggtct ggttcttcaa cacctcagcg ctcctgttct gctgccggcc tccacagacc     2880

tcggtcaagt gtcgattcca gcacagccga gaaccattca ctgtctggct ctctcactgg     2940

ttctttgact ggcagcactt tgtcctccgc ttccccgcgc ctgggcagtc ataccatgga     3000

tttttttgaa atgtgcgcca gtcttatcac tgctttagcc cgtaagctta tggtgagcaa     3060

gggcgaggag ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa     3120

cggccacagg ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac     3180

cctgaagttc atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac     3240

cctgacctgg ggcgtgcagt gcttcgcccg ctaccccgac cacatgaagc agcacgactt     3300

cttcaagtcc gccatgcccg aaggctacgt ccaggagcgt accatcttct tcaaggacga     3360

cggcaactac aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat     3420

cgagctgaag ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta     3480

caactacatc agccacaacg tctatatcac cgccgacaag cagaagaacg gcatcaaggc     3540

ccacttcaag atccgccaca acatcgagga cggcggcgtg cagctcgccg accactacca     3600

gcagaacacc cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac     3660

ccagtccaag ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt     3720

cgtgaccgcc gcctaatagc tcgagagatc cggctgctaa caaagcccga aaggaagctg     3780

agttggctgc tgccaccgct gagcaataac tagcataacc ccttggggcc tctaaacggg     3840

tcttgagggg ttttttggtt taaacccatc taattggact agtagcccgc ctaatgagcg     3900

ggcttttttt taattcccct atttgtttat ttttctaaat acattcaaat atgtatccgc     3960

tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta     4020

ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg     4080

ctcacccaga aacgctcgtg aaagtaaaag acgcagagga ccaattgggg gcacgagtgg     4140

gatacataga actggacttg aatagcggta aaatccttga gagttttcgc cctgaagagc     4200

gttttccaat gatgagcact ttcaaagttc tgctatgtgg agcagtatta tcccgtgtag     4260

atgcggggca agagcaactc ggacgacgaa tacactattc gcagaatgac ttggttgaat     4320

actccccagt gacagaaaag caccttacgg acggaatgac ggtaagagaa ttatgtagtg     4380

ccgccataac gatgagtgat aacactgcgg cgaacttact tctgacaacc atcggtggac     4440

cgaaggaatt aaccgctttt ttgcacaata tgggagacca tgtaactcgc cttgaccgtt     4500

gggaaccaga actgaatgaa gccataccaa acgacgagcg agacaccaca atgcctgcgg     4560

caatggcaac aacattacgc aaactattaa ctggcgaact acttactctg gcttcacggc     4620

aacaattaat agactggctt gaagcggata aagttgcagg accactactg cgttcggcac     4680

ttcctgctgg ctggtttatt gctgataaat ctggggcagg agagcgtggt tcacggggta     4740

tcattgccgc acttggacca gatggtaagc cttcccgtat cgtagttatc tacacgacgg     4800

gtagtcaggc aactatggac gaacgaaata gacagattgc tgaaataggg gcttcactga     4860

ttaagcattg gtaaaccgat acaattaaag gctccttttg gagccttttt ttttggacgg     4920

accggtagaa aagatcaaag gatcttc                                         4947


<210>  65
<211>  806
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat alpha2-mseCFP-11

<400>  65

Met Gly Ser Ser His His His His His His His His His His Ser Ser 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly His Met Ala Glu Lys Gln Lys His Asp 
            20                  25                  30          


Gly Arg Val Lys Ile Gly His Tyr Val Leu Gly Asp Thr Leu Gly Val 
        35                  40                  45              


Gly Thr Phe Gly Lys Val Lys Ile Gly Glu His Gln Leu Thr Gly His 
    50                  55                  60                  


Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg Ser Leu Asp 
65                  70                  75                  80  


Val Val Gly Lys Ile Lys Arg Glu Ile Gln Asn Leu Lys Leu Phe Arg 
                85                  90                  95      


His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr Pro Thr Asp 
            100                 105                 110         


Phe Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu Phe Asp Tyr 
        115                 120                 125             


Ile Cys Lys His Gly Arg Val Glu Glu Val Glu Ala Arg Arg Leu Phe 
    130                 135                 140                 


Gln Gln Ile Leu Ser Ala Val Asp Tyr Cys His Arg His Met Val Val 
145                 150                 155                 160 


His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala Gln Met Asn 
                165                 170                 175     


Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser Asp Gly Glu 
            180                 185                 190         


Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala Pro Glu Val 
        195                 200                 205             


Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile Trp Ser Cys 
    210                 215                 220                 


Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro Phe Asp Asp 
225                 230                 235                 240 


Glu His Val Pro Thr Leu Phe Lys Lys Ile Arg Gly Gly Val Phe Tyr 
                245                 250                 255     


Ile Pro Glu Tyr Leu Asn Arg Ser Ile Ala Thr Leu Leu Met His Met 
            260                 265                 270         


Leu Gln Val Asp Pro Leu Lys Arg Ala Thr Ile Lys Asp Ile Arg Glu 
        275                 280                 285             


His Glu Trp Phe Lys Gln Asp Leu Pro Ser Tyr Leu Phe Pro Glu Asp 
    290                 295                 300                 


Pro Ser Tyr Asp Ala Asn Val Ile Asp Asp Glu Ala Val Lys Glu Val 
305                 310                 315                 320 


Cys Glu Lys Phe Glu Cys Thr Glu Ser Glu Val Met Asn Ser Leu Tyr 
                325                 330                 335     


Ser Gly Asp Pro Gln Asp Gln Leu Ala Val Ala Tyr His Leu Ile Ile 
            340                 345                 350         


Asp Asn Arg Arg Ile Met Asn Gln Ala Ser Glu Phe Tyr Leu Ala Ser 
        355                 360                 365             


Ser Pro Pro Thr Gly Ser Phe Met Asp Asp Ser Ala Met His Ile Pro 
    370                 375                 380                 


Pro Gly Leu Lys Pro His Pro Glu Arg Met Pro Pro Leu Ile Ala Asp 
385                 390                 395                 400 


Ser Pro Lys Ala Arg Cys Pro Leu Asp Ala Leu Asn Thr Thr Lys Pro 
                405                 410                 415     


Lys Ser Leu Ala Val Lys Lys Ala Lys Trp His Leu Gly Ile Arg Ser 
            420                 425                 430         


Gln Ser Lys Pro Tyr Asp Ile Met Ala Glu Val Tyr Arg Ala Met Lys 
        435                 440                 445             


Gln Leu Asp Phe Glu Trp Lys Val Val Asn Ala Tyr His Leu Arg Val 
    450                 455                 460                 


Arg Arg Lys Asn Pro Val Thr Gly Asn Tyr Val Lys Met Ser Leu Gln 
465                 470                 475                 480 


Leu Tyr Leu Val Asp Asn Arg Ser Tyr Leu Leu Asp Phe Lys Ser Ile 
                485                 490                 495     


Asp Asp Glu Val Val Glu Gln Arg Ser Gly Ser Ser Thr Pro Gln Arg 
            500                 505                 510         


Ser Cys Ser Ala Ala Gly Leu His Arg Pro Arg Ser Ser Val Asp Ser 
        515                 520                 525             


Ser Thr Ala Glu Asn His Ser Leu Ser Gly Ser Leu Thr Gly Ser Leu 
    530                 535                 540                 


Thr Gly Ser Thr Leu Ser Ser Ala Ser Pro Arg Leu Gly Ser His Thr 
545                 550                 555                 560 


Met Asp Phe Phe Glu Met Cys Ala Ser Leu Ile Thr Ala Leu Ala Arg 
                565                 570                 575     


Lys Leu Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
            580                 585                 590         


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Arg Phe Ser Val 
        595                 600                 605             


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
    610                 615                 620                 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
625                 630                 635                 640 


Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His 
                645                 650                 655     


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
            660                 665                 670         


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
        675                 680                 685             


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
    690                 695                 700                 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
705                 710                 715                 720 


Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln 
                725                 730                 735     


Lys Asn Gly Ile Lys Ala His Phe Lys Ile Arg His Asn Ile Glu Asp 
            740                 745                 750         


Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
        755                 760                 765             


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
    770                 775                 780                 


Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
785                 790                 795                 800 


Glu Phe Val Thr Ala Ala 
                805     


<210>  66
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mseCFP-11

<400>  66
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacag gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgacctg gggcgtgcag tgcttcgccc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg taccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacat cagccacaac gtctatatca ccgccgacaa gcagaagaac      480

ggcatcaagg cccacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccaa gctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgcctaa                                          687


<210>  67
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mseCFP-11

<400>  67

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Arg Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala His Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala 
225             


<210>  68
<211>  4950
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat mseCFP-11-alpha2, pACE plasmid

<400>  68
ggaattccag ataacttcgt ataatgtatg ctatacgaag ttatggtacc gcggccgcgt       60

agaggatctg ttgatcagca gttcaacctg ttgatagtac ttcgttaata cagatgtagg      120

tgttggcacc atgcataact ataacggtcc taaggtagcg acctaggtat cgataatacg      180

actcactata ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa      240

ctttaagaag gagatataat gggcagtagt caccatcacc accaccatca tcaccatcat      300

agtagtgaaa acctgtattt tcaggggcat atggtgagca agggcgagga gctgttcacc      360

ggggtggtgc ccatcctggt cgagctggac ggcgacgtaa acggccacag gttcagcgtg      420

tccggcgagg gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc      480

accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca ccctgacctg gggcgtgcag      540

tgcttcgccc gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc      600

gaaggctacg tccaggagcg taccatcttc ttcaaggacg acggcaacta caagacccgc      660

gccgaggtga agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac      720

ttcaaggagg acggcaacat cctggggcac aagctggagt acaactacat cagccacaac      780

gtctatatca ccgccgacaa gcagaagaac ggcatcaagg cccacttcaa gatccgccac      840

aacatcgagg acggcggcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc      900

gacggccccg tgctgctgcc cgacaaccac tacctgagca cccagtccaa gctgagcaaa      960

gaccccaacg agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccggcggt     1020

atggctgaga agcagaagca cgacgggcgt gtgaagatcg gacactacgt gctgggggac     1080

accctgggcg tcggcacctt cggcaaagtg aagattggag aacatcaatt gacaggccat     1140

aaagtggcag ttaagatctt aaatagacag aagattcgca gtttagatgt tgttggaaaa     1200

ataaaacgag aaattcaaaa tcttaaactc tttcgtcatc ctcatattat caaactctac     1260

caagtgatca gcactccaac agactttttt atggtaatgg aatatgtgtc tggaggtgaa     1320

ttgttcgact acatctgtaa acacgggagg gttgaagagg tggaagctcg ccggctcttc     1380

cagcagattc tgtctgccgt ggactactgt cacaggcaca tggttgtcca cagggacctg     1440

aagccagaga acgtgttgct ggacgcccag atgaatgcta agatagctga cttcggactc     1500

tctaatatga tgtcagatgg tgaatttcta cgaactagct gtggatcgcc aaattatgca     1560

gcaccggagg tcatctcagg aaggctgtat gcgggtcctg aggttgatat ctggagctgt     1620

ggtgttatcc tgtatgccct tctctgtggc accctcccgt tcgacgatga gcacgtgcct     1680

acgctcttta agaagatccg agggggtgtg ttctacatcc cggagtatct caaccgttct     1740

attgccactc tgctgatgca catgctgcag gtggacccct tgaagcgagc aactatcaaa     1800

gacatacgag agcatgaatg gtttaaacag gatttgccca gttacctctt tcctgaagac     1860

ccctcctatg atgctaacgt cattgatgat gaggctgtga aagaagtatg tgaaaaattt     1920

gagtgtacag aatcagaagt gatgaacagt ttatacagtg gtgaccctca agaccagctc     1980

gcagtggctt atcatctcat cattgacaat cggagaataa tgaaccaagc cagtgagttc     2040

tacctcgcct ccagtcctcc aacgggttcc ttcatggacg atatggccat gcacattccc     2100

cccggcctga aaccacatcc tgaaaggatg ccacctctca tagcagacag ccccaaagca     2160

cgctgtccac tggatgcact caacacaact aagcccaaat ctttagctgt gaaaaaagcc     2220

aagtggcacc ttgggatccg aagccagagc aaaccatacg acattatggc ggaggtgtac     2280

cgagctatga agcagctgga ctttgaatgg aaggtagtga atgcatacca tcttcgagta     2340

agaagaaaaa acccagtgac tggcaattac gtgaaaatga gcttacagct ttacctggtt     2400

gacaatcgga gctatctgct ggactttaaa agcatcgatg atgaggtggt ggagcagagg     2460

tctggttctt caacacctca gcgctcctgt tctgctgccg gcctccacag acctcggtca     2520

agtgtcgatt ccagcacagc cgagaaccat tcactgtctg gctctctcac tggttctttg     2580

actggcagca ctttgtcctc cgcttccccg cgcctgggca gtcataccat ggattttttt     2640

gaaatgtgcg ccagtcttat cactgcttta gcccgtaagc tttaactcga gagatccggc     2700

tgctaacaaa gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactagc     2760

ataacccctt ggggcctcta aacgggtctt gaggggtttt ttggtttaaa cccatctaat     2820

tggactagta gcccgcctaa tgagcgggct tttttttaat tcccctattt gtttattttt     2880

ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata     2940

atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt     3000

tgcggcattt tgccttcctg tttttgctca cccagaaacg ctcgtgaaag taaaagacgc     3060

agaggaccaa ttgggggcac gagtgggata catagaactg gacttgaata gcggtaaaat     3120

ccttgagagt tttcgccctg aagagcgttt tccaatgatg agcactttca aagttctgct     3180

atgtggagca gtattatccc gtgtagatgc ggggcaagag caactcggac gacgaataca     3240

ctattcgcag aatgacttgg ttgaatactc cccagtgaca gaaaagcacc ttacggacgg     3300

aatgacggta agagaattat gtagtgccgc cataacgatg agtgataaca ctgcggcgaa     3360

cttacttctg acaaccatcg gtggaccgaa ggaattaacc gcttttttgc acaatatggg     3420

agaccatgta actcgccttg accgttggga accagaactg aatgaagcca taccaaacga     3480

cgagcgagac accacaatgc ctgcggcaat ggcaacaaca ttacgcaaac tattaactgg     3540

cgaactactt actctggctt cacggcaaca attaatagac tggcttgaag cggataaagt     3600

tgcaggacca ctactgcgtt cggcacttcc tgctggctgg tttattgctg ataaatctgg     3660

ggcaggagag cgtggttcac ggggtatcat tgccgcactt ggaccagatg gtaagccttc     3720

ccgtatcgta gttatctaca cgacgggtag tcaggcaact atggacgaac gaaatagaca     3780

gattgctgaa ataggggctt cactgattaa gcattggtaa accgatacaa ttaaaggctc     3840

cttttggagc cttttttttt ggacggaccg gtagaaaaga tcaaaggatc ttcttgagat     3900

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     3960

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     4020

gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac     4080

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     4140

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     4200

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     4260

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     4320

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     4380

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     4440

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     4500

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     4560

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     4620

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgcct gatgcggtat     4680

tttctcctta cgcatctgtg cggtatttca caccgcaatg gtgcactctc agtacaatct     4740

gctctgatgc cgcatagtta agccagtata cactccgcta tcgctacgtg actgggtcat     4800

ggctgcgccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc     4860

ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc     4920

accgtcatca ccgaaacgcg cgaggcaggg                                      4950


<210>  69
<211>  808
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat mseCFP-11-alpha2

<400>  69

Met Gly Ser Ser His His His His His His His His His His Ser Ser 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly His Met Val Ser Lys Gly Glu Glu Leu 
            20                  25                  30          


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        35                  40                  45              


Gly His Arg Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
    50                  55                  60                  


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
65                  70                  75                  80  


Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Trp Gly Val Gln Cys Phe 
                85                  90                  95      


Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            100                 105                 110         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
        115                 120                 125             


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    130                 135                 140                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
145                 150                 155                 160 


Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr 
                165                 170                 175     


Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala His Phe Lys Ile 
            180                 185                 190         


Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln 
        195                 200                 205             


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
    210                 215                 220                 


Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg 
225                 230                 235                 240 


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Gly Met Ala 
                245                 250                 255     


Glu Lys Gln Lys His Asp Gly Arg Val Lys Ile Gly His Tyr Val Leu 
            260                 265                 270         


Gly Asp Thr Leu Gly Val Gly Thr Phe Gly Lys Val Lys Ile Gly Glu 
        275                 280                 285             


His Gln Leu Thr Gly His Lys Val Ala Val Lys Ile Leu Asn Arg Gln 
    290                 295                 300                 


Lys Ile Arg Ser Leu Asp Val Val Gly Lys Ile Lys Arg Glu Ile Gln 
305                 310                 315                 320 


Asn Leu Lys Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr Gln Val 
                325                 330                 335     


Ile Ser Thr Pro Thr Asp Phe Phe Met Val Met Glu Tyr Val Ser Gly 
            340                 345                 350         


Gly Glu Leu Phe Asp Tyr Ile Cys Lys His Gly Arg Val Glu Glu Val 
        355                 360                 365             


Glu Ala Arg Arg Leu Phe Gln Gln Ile Leu Ser Ala Val Asp Tyr Cys 
    370                 375                 380                 


His Arg His Met Val Val His Arg Asp Leu Lys Pro Glu Asn Val Leu 
385                 390                 395                 400 


Leu Asp Ala Gln Met Asn Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn 
                405                 410                 415     


Met Met Ser Asp Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn 
            420                 425                 430         


Tyr Ala Ala Pro Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu 
        435                 440                 445             


Val Asp Ile Trp Ser Cys Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly 
    450                 455                 460                 


Thr Leu Pro Phe Asp Asp Glu His Val Pro Thr Leu Phe Lys Lys Ile 
465                 470                 475                 480 


Arg Gly Gly Val Phe Tyr Ile Pro Glu Tyr Leu Asn Arg Ser Ile Ala 
                485                 490                 495     


Thr Leu Leu Met His Met Leu Gln Val Asp Pro Leu Lys Arg Ala Thr 
            500                 505                 510         


Ile Lys Asp Ile Arg Glu His Glu Trp Phe Lys Gln Asp Leu Pro Ser 
        515                 520                 525             


Tyr Leu Phe Pro Glu Asp Pro Ser Tyr Asp Ala Asn Val Ile Asp Asp 
    530                 535                 540                 


Glu Ala Val Lys Glu Val Cys Glu Lys Phe Glu Cys Thr Glu Ser Glu 
545                 550                 555                 560 


Val Met Asn Ser Leu Tyr Ser Gly Asp Pro Gln Asp Gln Leu Ala Val 
                565                 570                 575     


Ala Tyr His Leu Ile Ile Asp Asn Arg Arg Ile Met Asn Gln Ala Ser 
            580                 585                 590         


Glu Phe Tyr Leu Ala Ser Ser Pro Pro Thr Gly Ser Phe Met Asp Asp 
        595                 600                 605             


Met Ala Met His Ile Pro Pro Gly Leu Lys Pro His Pro Glu Arg Met 
    610                 615                 620                 


Pro Pro Leu Ile Ala Asp Ser Pro Lys Ala Arg Cys Pro Leu Asp Ala 
625                 630                 635                 640 


Leu Asn Thr Thr Lys Pro Lys Ser Leu Ala Val Lys Lys Ala Lys Trp 
                645                 650                 655     


His Leu Gly Ile Arg Ser Gln Ser Lys Pro Tyr Asp Ile Met Ala Glu 
            660                 665                 670         


Val Tyr Arg Ala Met Lys Gln Leu Asp Phe Glu Trp Lys Val Val Asn 
        675                 680                 685             


Ala Tyr His Leu Arg Val Arg Arg Lys Asn Pro Val Thr Gly Asn Tyr 
    690                 695                 700                 


Val Lys Met Ser Leu Gln Leu Tyr Leu Val Asp Asn Arg Ser Tyr Leu 
705                 710                 715                 720 


Leu Asp Phe Lys Ser Ile Asp Asp Glu Val Val Glu Gln Arg Ser Gly 
                725                 730                 735     


Ser Ser Thr Pro Gln Arg Ser Cys Ser Ala Ala Gly Leu His Arg Pro 
            740                 745                 750         


Arg Ser Ser Val Asp Ser Ser Thr Ala Glu Asn His Ser Leu Ser Gly 
        755                 760                 765             


Ser Leu Thr Gly Ser Leu Thr Gly Ser Thr Leu Ser Ser Ala Ser Pro 
    770                 775                 780                 


Arg Leu Gly Ser His Thr Met Asp Phe Phe Glu Met Cys Ala Ser Leu 
785                 790                 795                 800 


Ile Thr Ala Leu Ala Arg Lys Leu 
                805             


<210>  70
<211>  3520
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-mseCFP-11, pDS plasmid

<400>  70
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga taatacgact cactataggg gaattgtgag      900

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat      960

ggagtcggtt gctgcagaga gcgctccagc tccggagaat gaacactctc aagagacccc     1020

ggaatcgaac agtagtgtgt acaccacctt catgaagtct catcgctgct atgacctgat     1080

ccccacaagc tccaagctgg tggtatttga tacttcgctg caggtaaaga aagccttctt     1140

tgccctggtg actaacggtg ttcgtgctgc ccctttgtgg gatagtaaga agcagagctt     1200

tgtgggcatg ctgaccatca ctgacttcat caatattctg caccgatact acaagtcagc     1260

cctggtgcag atctatgaac tggaggagca caagatagag acttggagag aggtctacct     1320

gcaagactcc tttaagccac ttgtctgcat ttctccaaat gccagcttgt tcgatgctgt     1380

ctcttcatta attcgaaata agatccacag gcttccagtt attgacccgg agtcaggcaa     1440

caccttgtac attcttactc acaagcggat cctcaagttc ctcaagttgt ttatcactga     1500

gttccccaag ccggaattca tgtctaagtc tctggaagag ctacagattg gcacctacgc     1560

caatattgcc atggtccgta ccactacacc tgtctatgtg gctctgggca tctttgtaca     1620

gcaccgagtc tccgccttgc ctgtggtgga tgagaaaggg cgtgtggtgg acatctactc     1680

caagtttgat gtgattaatt tggcagcaga aaagacatac aacaacctag atgtgtctgt     1740

gacaaaagcc ctacagcacc ggtcacacta cttcgagggt gttctcaagt gctacctaca     1800

tgagactcta gaagcaatca tcaatagact ggtggaagca gaggttcacc gtctggtggt     1860

ggtggatgaa catgacgtgg tcaagggcat tgtatcgctg tctgacatct tacaggctct     1920

ggtgctcaca ggtggagaga agaagcccgc tagcatggtg agcaagggcg aggagctgtt     1980

caccggggtg gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaggttcag     2040

cgtgtccggc gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg     2100

caccaccggc aagctgcccg tgccctggcc caccctcgtg accaccctga cctggggcgt     2160

gcagtgcttc gcccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat     2220

gcccgaaggc tacgtccagg agcgtaccat cttcttcaag gacgacggca actacaagac     2280

ccgcgccgag gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat     2340

cgacttcaag gaggacggca acatcctggg gcacaagctg gagtacaact acatcagcca     2400

caacgtctat atcaccgccg acaagcagaa gaacggcatc aaggcccact tcaagatccg     2460

ccacaacatc gaggacggcg gcgtgcagct cgccgaccac taccagcaga acacccccat     2520

cggcgacggc cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccaagctgag     2580

caaagacccc aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccta     2640

ataggtttaa accatgtgcc tggcagataa cttcgtataa tgtatgctat acgaagttat     2700

ggtacgtact aagctctcat gtttcacgta ctaagctctc atgtttaacg tactaagctc     2760

tcatgtttaa cgaactaaac cctcatggct aacgtactaa gctctcatgg ctaacgtact     2820

aagctctcat gtttcacgta ctaagctctc atgtttgaac aataaaatta atataaatca     2880

gcaacttaaa tagcctctaa ggttttaagt tttataagaa aaaaaagaat atataaggct     2940

tttaaagctt ttaaggttta acggttgtgg acaacaagcc agggatgtaa cgcactgaga     3000

agcccttaga gcctctcaaa gcaattttga gtgacacagg aacacttaac ggctgacata     3060

attcagcttc acgctgccgc aagcactcag ggcgcaaggg ctgctaaagg aagcggaaca     3120

cgtagaaagc cagtccgcag aaacggtgct gaccccggat gaatgtcagc tgggaggcag     3180

aataaatgat catatcgtca attattacct ccacggggag agcctgagca aactggcctc     3240

aggcatttga gaagcacacg gtcacactgc ttccggtagt caataaaccg gtaagtagcg     3300

tatgcgctca cgcaactggt ccagaacctt gaccgaacgc agcggtggta acggcgcagt     3360

ggcggttttc atggcttgtt atgactgttt ttttggggta cagtctatgc ctcgggcatc     3420

caagcagcaa gcgcgttacg ccgtgggtcg atgtttgatg ttatggagca gcaacgatgt     3480

tacgcagcag ggcagtcgcc ctaaaacaaa gttaaacatc                           3520


<210>  71
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-mseCFP-11

<400>  71

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro Ala Ser Met Val Ser Lys 
                325                 330                 335     


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
            340                 345                 350         


Gly Asp Val Asn Gly His Arg Phe Ser Val Ser Gly Glu Gly Glu Gly 
        355                 360                 365             


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
    370                 375                 380                 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Trp Gly 
385                 390                 395                 400 


Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
                405                 410                 415     


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
            420                 425                 430         


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
        435                 440                 445             


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
    450                 455                 460                 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Ile Ser 
465                 470                 475                 480 


His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
                485                 490                 495     


His Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala 
            500                 505                 510         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        515                 520                 525             


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro 
    530                 535                 540                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
545                 550                 555                 560 


<210>  72
<211>  3529
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat eCFP-11-gamma1, pDS plasmid

<400>  72
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga taatacgact cactataggg gaattgtgag      900

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat      960

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     1020

cgacgtaaac ggccacaggt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     1080

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     1140

cgtgaccacc ctgacctggg gcgtgcagtg cttcgcccgc taccccgacc acatgaagca     1200

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgta ccatcttctt     1260

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     1320

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     1380

gctggagtac aactacatca gccacaacgt ctatatcacc gccgacaagc agaagaacgg     1440

catcaaggcc cacttcaaga tccgccacaa catcgaggac ggcggcgtgc agctcgccga     1500

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     1560

cctgagcacc cagtccaagc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     1620

gctggagttc gtgaccgccg ccgctagcat ggagtcggtt gctgcagaga gcgctccagc     1680

tccggagaat gaacactctc aagagacccc ggaatcgaac agtagtgtgt acaccacctt     1740

catgaagtct catcgctgct atgacctgat ccccacaagc tccaagctgg tggtatttga     1800

tacttcgctg caggtaaaga aagccttctt tgccctggtg actaacggtg ttcgtgctgc     1860

ccctttgtgg gatagtaaga agcagagctt tgtgggcatg ctgaccatca ctgacttcat     1920

caatattctg caccgatact acaagtcagc cctggtgcag atctatgaac tggaggagca     1980

caagatagag acttggagag aggtctacct gcaagactcc tttaagccac ttgtctgcat     2040

ttctccaaat gccagcttgt tcgatgctgt ctcttcatta attcgaaata agatccacag     2100

gcttccagtt attgacccgg agtcaggcaa caccttgtac attcttactc acaagcggat     2160

cctcaagttc ctcaagttgt ttatcactga gttccccaag ccggaattca tgtctaagtc     2220

tctggaagag ctacagattg gcacctacgc caatattgcc atggtccgta ccactacacc     2280

tgtctatgtg gctctgggca tctttgtaca gcaccgagtc tccgccttgc ctgtggtgga     2340

tgagaaaggg cgtgtggtgg acatctactc caagtttgat gtgattaatt tggcagcaga     2400

aaagacatac aacaacctag atgtgtctgt gacaaaagcc ctacagcacc ggtcacacta     2460

cttcgagggt gttctcaagt gctacctaca tgagactcta gaagcaatca tcaatagact     2520

ggtggaagca gaggttcacc gtctggtggt ggtggatgaa catgacgtgg tcaagggcat     2580

tgtatcgctg tctgacatct tacaggctct ggtgctcaca ggtggagaga agaagccctg     2640

ataactagtt ccgtttaaac ccatgtgcct ggcagataac ttcgtataat gtatgctata     2700

cgaagttatg gtacgtacta agctctcatg tttcacgtac taagctctca tgtttaacgt     2760

actaagctct catgtttaac gaactaaacc ctcatggcta acgtactaag ctctcatggc     2820

taacgtacta agctctcatg tttcacgtac taagctctca tgtttgaaca ataaaattaa     2880

tataaatcag caacttaaat agcctctaag gttttaagtt ttataagaaa aaaaagaata     2940

tataaggctt ttaaagcttt taaggtttaa cggttgtgga caacaagcca gggatgtaac     3000

gcactgagaa gcccttagag cctctcaaag caattttgag tgacacagga acacttaacg     3060

gctgacataa ttcagcttca cgctgccgca agcactcagg gcgcaagggc tgctaaagga     3120

agcggaacac gtagaaagcc agtccgcaga aacggtgctg accccggatg aatgtcagct     3180

gggaggcaga ataaatgatc atatcgtcaa ttattacctc cacggggaga gcctgagcaa     3240

actggcctca ggcatttgag aagcacacgg tcacactgct tccggtagtc aataaaccgg     3300

taagtagcgt atgcgctcac gcaactggtc cagaaccttg accgaacgca gcggtggtaa     3360

cggcgcagtg gcggttttca tggcttgtta tgactgtttt tttggggtac agtctatgcc     3420

tcgggcatcc aagcagcaag cgcgttacgc cgtgggtcga tgtttgatgt tatggagcag     3480

caacgatgtt acgcagcagg gcagtcgccc taaaacaaag ttaaacatc                 3529


<210>  73
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat eCFP-11-gamma1

<400>  73

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Arg Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala His Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Ala Ser Met Glu Ser Val Ala Ala Glu Ser Ala Pro 
225                 230                 235                 240 


Ala Pro Glu Asn Glu His Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser 
                245                 250                 255     


Val Tyr Thr Thr Phe Met Lys Ser His Arg Cys Tyr Asp Leu Ile Pro 
            260                 265                 270         


Thr Ser Ser Lys Leu Val Val Phe Asp Thr Ser Leu Gln Val Lys Lys 
        275                 280                 285             


Ala Phe Phe Ala Leu Val Thr Asn Gly Val Arg Ala Ala Pro Leu Trp 
    290                 295                 300                 


Asp Ser Lys Lys Gln Ser Phe Val Gly Met Leu Thr Ile Thr Asp Phe 
305                 310                 315                 320 


Ile Asn Ile Leu His Arg Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr 
                325                 330                 335     


Glu Leu Glu Glu His Lys Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln 
            340                 345                 350         


Asp Ser Phe Lys Pro Leu Val Cys Ile Ser Pro Asn Ala Ser Leu Phe 
        355                 360                 365             


Asp Ala Val Ser Ser Leu Ile Arg Asn Lys Ile His Arg Leu Pro Val 
    370                 375                 380                 


Ile Asp Pro Glu Ser Gly Asn Thr Leu Tyr Ile Leu Thr His Lys Arg 
385                 390                 395                 400 


Ile Leu Lys Phe Leu Lys Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu 
                405                 410                 415     


Phe Met Ser Lys Ser Leu Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn 
            420                 425                 430         


Ile Ala Met Val Arg Thr Thr Thr Pro Val Tyr Val Ala Leu Gly Ile 
        435                 440                 445             


Phe Val Gln His Arg Val Ser Ala Leu Pro Val Val Asp Glu Lys Gly 
    450                 455                 460                 


Arg Val Val Asp Ile Tyr Ser Lys Phe Asp Val Ile Asn Leu Ala Ala 
465                 470                 475                 480 


Glu Lys Thr Tyr Asn Asn Leu Asp Val Ser Val Thr Lys Ala Leu Gln 
                485                 490                 495     


His Arg Ser His Tyr Phe Glu Gly Val Leu Lys Cys Tyr Leu His Glu 
            500                 505                 510         


Thr Leu Glu Ala Ile Ile Asn Arg Leu Val Glu Ala Glu Val His Arg 
        515                 520                 525             


Leu Val Val Val Asp Glu His Asp Val Val Lys Gly Ile Val Ser Leu 
    530                 535                 540                 


Ser Asp Ile Leu Gln Ala Leu Val Leu Thr Gly Gly Glu Lys Lys Pro 
545                 550                 555                 560 


<210>  74
<211>  4995
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat alpha2-AR-eCFP_deletion, pACE plasmid

<400>  74
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa      600

cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc      660

gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg      720

ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcctgat      780

gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcaatggtg cactctcagt      840

acaatctgct ctgatgccgc atagttaagc cagtatacac tccgctatcg ctacgtgact      900

gggtcatggc tgcgccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc      960

tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga     1020

ggttttcacc gtcatcaccg aaacgcgcga ggcaggggga attccagata acttcgtata     1080

atgtatgcta tacgaagtta tggtaccgcg gccgcgtaga ggatctgttg atcagcagtt     1140

caacctgttg atagtacttc gttaatacag atgtaggtgt tggcaccatg cataactata     1200

acggtcctaa ggtagcgacc taggtatcga taatacgact cactataggg gaattgtgag     1260

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atataatggg     1320

cagtagtcac catcaccacc accatcatca ccatcatagt agtgaaaacc tgtattttca     1380

ggggcatatg gctgagaagc agaagcacga cgggcgtgtg aagatcggac actacgtgct     1440

gggggacacc ctgggcgtcg gcaccttcgg caaagtgaag attggagaac atcaattgac     1500

aggccataaa gtggcagtta agatcttaaa tagacagaag attcgcagtt tagatgttgt     1560

tggaaaaata aaacgagaaa ttcaaaatct taaactcttt cgtcatcctc atattatcaa     1620

actctaccaa gtgatcagca ctccaacaga cttttttatg gtaatggaat atgtgtctgg     1680

aggtgaattg ttcgactaca tctgtaaaca cgggagggtt gaagaggtgg aagctcgccg     1740

gctcttccag cagattctgt ctgccgtgga ctactgtcac aggcacatgg ttgtccacag     1800

ggacctgaag ccagagaacg tgttgctgga cgcccagatg aatgctaaga tagctgactt     1860

cggactctct aatatgatgt cagatggtga atttctacga actagctgtg gatcgccaaa     1920

ttatgcagca ccggaggtca tctcaggaag gctgtatgcg ggtcctgagg ttgatatctg     1980

gagctgtggt gttatcctgt atgcccttct ctgtggcacc ctcccgttcg acgatgagca     2040

cgtgcctacg ctctttaaga agatccgagg gggtgtgttc tacatcccgg agtatctcaa     2100

ccgttctatt gccactctgc tgatgcacat gctgcaggtg gaccccttga agcgagcaac     2160

tatcaaagac atacgagagc atgaatggtt taaacaggat ttgcccagtt acctctttcc     2220

tgaagacccc tcctatgatg ctaacgtcat tgatgatgag gctgtgaaag aagtatgtga     2280

aaaatttgag tgtacagaat cagaagtgat gaacagttta tacagtggtg accctcaaga     2340

ccagctcgca gtggcttatc atctcatcat tgacaatcgg agaataatga accaagccag     2400

tgagttctac ctcgcctcca gtcctccaac gggttccttc atggacgata tggccatgca     2460

cattcccccc ggcctgaaac cacatcctga aaggatgcca cctctcatag cagacagccc     2520

caaagcacgc tgtccactgg atgcactcaa cacaactaag cccaaatctt tagctgtgaa     2580

aaaagccaag tggcaccttg ggatccgaag ccagagcaaa ccatacgaca ttatggcgga     2640

ggtgtaccga gctatgaagc agctggactt tgaatggaag gtagtgaatg cataccatct     2700

tcgagtaaga agaaaaaacc cagtgactgg caattacgtg aaaatgagct tacagcttta     2760

cctggttgac aatcggagct atctgctgga ctttaaaagc atcgatgatg aggtggtgga     2820

gcagaggtct ggttcttcaa cacctcagcg ctcctgttct gctgccggcc tccacagacc     2880

tcggtcaagt gtcgattcca gcacagccga gaaccattca ctgtctggct ctctcactgg     2940

ttctttgact ggcagcactt tgtcctccgc ttccccgcgc ctgggcagtc ataccatgga     3000

tttttttgaa atgtgcgcca gtcttatcac tgctttaatg gtgagcaagg gcgaggagct     3060

gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt     3120

cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat     3180

ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctgggg     3240

cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc     3300

catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa     3360

gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg     3420

catcgacttc aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacatcag     3480

ccacaacgtc tatatcaccg ccgacaagca gaagaacggc atcaaggcca acttcaagat     3540

ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc     3600

catcggcgac ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct     3660

gagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc     3720

cgggatcact ctcggcatgg acgagctgta caagtccgga ctcagatctc gacgagctca     3780

ctgataactc gagagatccg gctgctaaca aagcccgaaa ggaagctgag ttggctgctg     3840

ccaccgctga gcaataacta gcataacccc ttggggcctc taaacgggtc ttgaggggtt     3900

ttttggttta aacccatcta attggactag tagcccgcct aatgagcggg ctttttttta     3960

attcccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat     4020

aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc     4080

gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa     4140

cgctcgtgaa agtaaaagac gcagaggacc aattgggggc acgagtggga tacatagaac     4200

tggacttgaa tagcggtaaa atccttgaga gttttcgccc tgaagagcgt tttccaatga     4260

tgagcacttt caaagttctg ctatgtggag cagtattatc ccgtgtagat gcggggcaag     4320

agcaactcgg acgacgaata cactattcgc agaatgactt ggttgaatac tccccagtga     4380

cagaaaagca ccttacggac ggaatgacgg taagagaatt atgtagtgcc gccataacga     4440

tgagtgataa cactgcggcg aacttacttc tgacaaccat cggtggaccg aaggaattaa     4500

ccgctttttt gcacaatatg ggagaccatg taactcgcct tgaccgttgg gaaccagaac     4560

tgaatgaagc cataccaaac gacgagcgag acaccacaat gcctgcggca atggcaacaa     4620

cattacgcaa actattaact ggcgaactac ttactctggc ttcacggcaa caattaatag     4680

actggcttga agcggataaa gttgcaggac cactactgcg ttcggcactt cctgctggct     4740

ggtttattgc tgataaatct ggggcaggag agcgtggttc acggggtatc attgccgcac     4800

ttggaccaga tggtaagcct tcccgtatcg tagttatcta cacgacgggt agtcaggcaa     4860

ctatggacga acgaaataga cagattgctg aaataggggc ttcactgatt aagcattggt     4920

aaaccgatac aattaaaggc tccttttgga gccttttttt ttggacggac cggtagaaaa     4980

gatcaaagga tcttc                                                      4995


<210>  75
<211>  822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat alpha2-AR-eCFP_deletion

<400>  75

Met Gly Ser Ser His His His His His His His His His His Ser Ser 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly His Met Ala Glu Lys Gln Lys His Asp 
            20                  25                  30          


Gly Arg Val Lys Ile Gly His Tyr Val Leu Gly Asp Thr Leu Gly Val 
        35                  40                  45              


Gly Thr Phe Gly Lys Val Lys Ile Gly Glu His Gln Leu Thr Gly His 
    50                  55                  60                  


Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg Ser Leu Asp 
65                  70                  75                  80  


Val Val Gly Lys Ile Lys Arg Glu Ile Gln Asn Leu Lys Leu Phe Arg 
                85                  90                  95      


His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr Pro Thr Asp 
            100                 105                 110         


Phe Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu Phe Asp Tyr 
        115                 120                 125             


Ile Cys Lys His Gly Arg Val Glu Glu Val Glu Ala Arg Arg Leu Phe 
    130                 135                 140                 


Gln Gln Ile Leu Ser Ala Val Asp Tyr Cys His Arg His Met Val Val 
145                 150                 155                 160 


His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala Gln Met Asn 
                165                 170                 175     


Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser Asp Gly Glu 
            180                 185                 190         


Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala Pro Glu Val 
        195                 200                 205             


Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile Trp Ser Cys 
    210                 215                 220                 


Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro Phe Asp Asp 
225                 230                 235                 240 


Glu His Val Pro Thr Leu Phe Lys Lys Ile Arg Gly Gly Val Phe Tyr 
                245                 250                 255     


Ile Pro Glu Tyr Leu Asn Arg Ser Ile Ala Thr Leu Leu Met His Met 
            260                 265                 270         


Leu Gln Val Asp Pro Leu Lys Arg Ala Thr Ile Lys Asp Ile Arg Glu 
        275                 280                 285             


His Glu Trp Phe Lys Gln Asp Leu Pro Ser Tyr Leu Phe Pro Glu Asp 
    290                 295                 300                 


Pro Ser Tyr Asp Ala Asn Val Ile Asp Asp Glu Ala Val Lys Glu Val 
305                 310                 315                 320 


Cys Glu Lys Phe Glu Cys Thr Glu Ser Glu Val Met Asn Ser Leu Tyr 
                325                 330                 335     


Ser Gly Asp Pro Gln Asp Gln Leu Ala Val Ala Tyr His Leu Ile Ile 
            340                 345                 350         


Asp Asn Arg Arg Ile Met Asn Gln Ala Ser Glu Phe Tyr Leu Ala Ser 
        355                 360                 365             


Ser Pro Pro Thr Gly Ser Phe Met Asp Asp Met Ala Met His Ile Pro 
    370                 375                 380                 


Pro Gly Leu Lys Pro His Pro Glu Arg Met Pro Pro Leu Ile Ala Asp 
385                 390                 395                 400 


Ser Pro Lys Ala Arg Cys Pro Leu Asp Ala Leu Asn Thr Thr Lys Pro 
                405                 410                 415     


Lys Ser Leu Ala Val Lys Lys Ala Lys Trp His Leu Gly Ile Arg Ser 
            420                 425                 430         


Gln Ser Lys Pro Tyr Asp Ile Met Ala Glu Val Tyr Arg Ala Met Lys 
        435                 440                 445             


Gln Leu Asp Phe Glu Trp Lys Val Val Asn Ala Tyr His Leu Arg Val 
    450                 455                 460                 


Arg Arg Lys Asn Pro Val Thr Gly Asn Tyr Val Lys Met Ser Leu Gln 
465                 470                 475                 480 


Leu Tyr Leu Val Asp Asn Arg Ser Tyr Leu Leu Asp Phe Lys Ser Ile 
                485                 490                 495     


Asp Asp Glu Val Val Glu Gln Arg Ser Gly Ser Ser Thr Pro Gln Arg 
            500                 505                 510         


Ser Cys Ser Ala Ala Gly Leu His Arg Pro Arg Ser Ser Val Asp Ser 
        515                 520                 525             


Ser Thr Ala Glu Asn His Ser Leu Ser Gly Ser Leu Thr Gly Ser Leu 
    530                 535                 540                 


Thr Gly Ser Thr Leu Ser Ser Ala Ser Pro Arg Leu Gly Ser His Thr 
545                 550                 555                 560 


Met Asp Phe Phe Glu Met Cys Ala Ser Leu Ile Thr Ala Leu Met Val 
                565                 570                 575     


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
            580                 585                 590         


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
        595                 600                 605             


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
    610                 615                 620                 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
625                 630                 635                 640 


Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
                645                 650                 655     


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
            660                 665                 670         


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
        675                 680                 685             


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
    690                 695                 700                 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
705                 710                 715                 720 


Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile 
                725                 730                 735     


Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
            740                 745                 750         


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
        755                 760                 765             


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
    770                 775                 780                 


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
785                 790                 795                 800 


Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu 
                805                 810                 815     


Arg Ser Arg Arg Ala His 
            820         


<210>  76
<211>  5007
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat alpha2-AR_helix_-MVSKeCFP_deletion+alpha helix, pACE plasmid

<400>  76
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa      600

cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc      660

gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg      720

ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcctgat      780

gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcaatggtg cactctcagt      840

acaatctgct ctgatgccgc atagttaagc cagtatacac tccgctatcg ctacgtgact      900

gggtcatggc tgcgccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc      960

tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga     1020

ggttttcacc gtcatcaccg aaacgcgcga ggcaggggga attccagata acttcgtata     1080

atgtatgcta tacgaagtta tggtaccgcg gccgcgtaga ggatctgttg atcagcagtt     1140

caacctgttg atagtacttc gttaatacag atgtaggtgt tggcaccatg cataactata     1200

acggtcctaa ggtagcgacc taggtatcga taatacgact cactataggg gaattgtgag     1260

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atataatggg     1320

cagtagtcac catcaccacc accatcatca ccatcatagt agtgaaaacc tgtattttca     1380

ggggcatatg gctgagaagc agaagcacga cgggcgtgtg aagatcggac actacgtgct     1440

gggggacacc ctgggcgtcg gcaccttcgg caaagtgaag attggagaac atcaattgac     1500

aggccataaa gtggcagtta agatcttaaa tagacagaag attcgcagtt tagatgttgt     1560

tggaaaaata aaacgagaaa ttcaaaatct taaactcttt cgtcatcctc atattatcaa     1620

actctaccaa gtgatcagca ctccaacaga cttttttatg gtaatggaat atgtgtctgg     1680

aggtgaattg ttcgactaca tctgtaaaca cgggagggtt gaagaggtgg aagctcgccg     1740

gctcttccag cagattctgt ctgccgtgga ctactgtcac aggcacatgg ttgtccacag     1800

ggacctgaag ccagagaacg tgttgctgga cgcccagatg aatgctaaga tagctgactt     1860

cggactctct aatatgatgt cagatggtga atttctacga actagctgtg gatcgccaaa     1920

ttatgcagca ccggaggtca tctcaggaag gctgtatgcg ggtcctgagg ttgatatctg     1980

gagctgtggt gttatcctgt atgcccttct ctgtggcacc ctcccgttcg acgatgagca     2040

cgtgcctacg ctctttaaga agatccgagg gggtgtgttc tacatcccgg agtatctcaa     2100

ccgttctatt gccactctgc tgatgcacat gctgcaggtg gaccccttga agcgagcaac     2160

tatcaaagac atacgagagc atgaatggtt taaacaggat ttgcccagtt acctctttcc     2220

tgaagacccc tcctatgatg ctaacgtcat tgatgatgag gctgtgaaag aagtatgtga     2280

aaaatttgag tgtacagaat cagaagtgat gaacagttta tacagtggtg accctcaaga     2340

ccagctcgca gtggcttatc atctcatcat tgacaatcgg agaataatga accaagccag     2400

tgagttctac ctcgcctcca gtcctccaac gggttccttc atggacgata tggccatgca     2460

cattcccccc ggcctgaaac cacatcctga aaggatgcca cctctcatag cagacagccc     2520

caaagcacgc tgtccactgg atgcactcaa cacaactaag cccaaatctt tagctgtgaa     2580

aaaagccaag tggcaccttg ggatccgaag ccagagcaaa ccatacgaca ttatggcgga     2640

ggtgtaccga gctatgaagc agctggactt tgaatggaag gtagtgaatg cataccatct     2700

tcgagtaaga agaaaaaacc cagtgactgg caattacgtg aaaatgagct tacagcttta     2760

cctggttgac aatcggagct atctgctgga ctttaaaagc atcgatgatg aggtggtgga     2820

gcagaggtct ggttcttcaa cacctcagcg ctcctgttct gctgccggcc tccacagacc     2880

tcggtcaagt gtcgattcca gcacagccga gaaccattca ctgtctggct ctctcactgg     2940

ttctttgact ggcagcactt tgtcctccgc ttccccgcgc ctgggcagtc ataccatgga     3000

tttttttgaa atgtgcgcca gtcttatcac tgctttagag gaggaagaga agaaaaagaa     3060

aggcgaggag ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa     3120

cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac     3180

cctgaagttc atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac     3240

cctgacctgg ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt     3300

cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga     3360

cggcaactac aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat     3420

cgagctgaag ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta     3480

caactacatc agccacaacg tctatatcac cgccgacaag cagaagaacg gcatcaaggc     3540

caacttcaag atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca     3600

gcagaacacc cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac     3660

ccagtccgcc ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt     3720

cgtgaccgcc gccgggatca ctctcggcat ggacgagctg tacaagtccg gactcagatc     3780

tcgacgagct cactgataac tcgagagatc cggctgctaa caaagcccga aaggaagctg     3840

agttggctgc tgccaccgct gagcaataac tagcataacc ccttggggcc tctaaacggg     3900

tcttgagggg ttttttggtt taaacccatc taattggact agtagcccgc ctaatgagcg     3960

ggcttttttt taattcccct atttgtttat ttttctaaat acattcaaat atgtatccgc     4020

tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta     4080

ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg     4140

ctcacccaga aacgctcgtg aaagtaaaag acgcagagga ccaattgggg gcacgagtgg     4200

gatacataga actggacttg aatagcggta aaatccttga gagttttcgc cctgaagagc     4260

gttttccaat gatgagcact ttcaaagttc tgctatgtgg agcagtatta tcccgtgtag     4320

atgcggggca agagcaactc ggacgacgaa tacactattc gcagaatgac ttggttgaat     4380

actccccagt gacagaaaag caccttacgg acggaatgac ggtaagagaa ttatgtagtg     4440

ccgccataac gatgagtgat aacactgcgg cgaacttact tctgacaacc atcggtggac     4500

cgaaggaatt aaccgctttt ttgcacaata tgggagacca tgtaactcgc cttgaccgtt     4560

gggaaccaga actgaatgaa gccataccaa acgacgagcg agacaccaca atgcctgcgg     4620

caatggcaac aacattacgc aaactattaa ctggcgaact acttactctg gcttcacggc     4680

aacaattaat agactggctt gaagcggata aagttgcagg accactactg cgttcggcac     4740

ttcctgctgg ctggtttatt gctgataaat ctggggcagg agagcgtggt tcacggggta     4800

tcattgccgc acttggacca gatggtaagc cttcccgtat cgtagttatc tacacgacgg     4860

gtagtcaggc aactatggac gaacgaaata gacagattgc tgaaataggg gcttcactga     4920

ttaagcattg gtaaaccgat acaattaaag gctccttttg gagccttttt ttttggacgg     4980

accggtagaa aagatcaaag gatcttc                                         5007


<210>  77
<211>  3493
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human beta2-KPI-YFP_deletion, pDC plasmid

<400>  77
cgccccgccc tgccactcat cgcagtactg ttgtaattca ttaagcattc tgccgacatg       60

gaagccatca caaacggcat gatgaacctg aatcgccagc ggcatcagca ccttgtcgcc      120

ttgcgtataa tatttgccca tggtgaaaac gggggcgaag aagttgtcca tattggccac      180

gtttaaatca aaactggtga aactcaccca gggattggct gagacgaaaa acatattctc      240

aataaaccct ttagggaaat aggccaggtt ttcaccgtaa cacgccacat cttgcgaata      300

tatgtgtaga aactgccgga aatcgtcgtg gtattcactc cagagcgatg aaaacgtttc      360

agtttgctca tggaaaacgg tgtaacaagg gtgaacacta tcccatatca ccagctcacc      420

gtctttcatt gccatacgga attccggatg agcattcatc aggcgggcaa gaatgtgaat      480

aaaggccgga taaaacttgt gcttattttt ctttacggtc tttaaaaagg ccgtaatatc      540

cagctgaacg gtctggttat aggtacattg agcaactgac tgaaatgcct caaaatgttc      600

tttacgatgc cattgggata tatcaacggt ggtatatcca gtgatttttt tctccatttt      660

agcttcctta gctcctgaaa atctcgataa ctcaaaaaat acgcccggta gtgatcttat      720

ttcattatgg tgaaagttgg accctcttac gtgccgatca acgtctcatt ttcgccaaaa      780

gttggcccag atcaacgtct cattttcgcc aaaagttggc ccagatctat gtcgggtgcg      840

gagaaagagg taatgaaatg gcacctaggt atcgataata cgactcacta taggggaatt      900

gtgagcggat aacaattccc ctctagaaat aattttgttt aactttaaga aggagatata      960

catatgaggc ctatgggaaa caccaccagc gaccgggtgt ccggggagcg ccacggcgcc     1020

aaggctgcac gctccgaggg cgcaggcggc catgccccgg ggaaggagca caagatcatg     1080

gtggggagta cggacgaccc cagcgtgttc agcctccctg actccaagct ccctggggac     1140

aaagagtttg tatcatggca gcaggatttg gaggactccg taaagcccac acagcaggcc     1200

cggcccactg ttatccgctg gtctgaagga ggcaaggagg tcttcatctc tgggtctttc     1260

aacaattgga gcaccaagat tccactgatt aagagccata atgactttgt tgccatcctg     1320

gacctccctg agggagagca ccaatacaag ttctttgtgg atggacagtg ggttcatgat     1380

ccatcagagc ctgtggttac cagtcagctt ggcacaatta acaatttgat ccatgtcaag     1440

aaatctgatt ttgaggtgtt cgatgcttta aagttagatt ctatggaaag ttctgagaca     1500

tcttgtagag acctttccag ctcaccccca gggccttatg gtcaagaaat gtatgcgttt     1560

cgatctgagg aaagattcaa atccccaccc atccttcctc ctcatctact tcaagttatt     1620

cttaacaaag acactaatat ttcttgtgac ccagccttac tccctgagcc caaccatgtt     1680

atgctgaacc atctctatgc attgtccatt aaggacagtg tgatggtcct tagcgcaacc     1740

catcgctaca agaagaagta tgttactact ctgctataca tggtgagcaa gggcgaggag     1800

ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag     1860

ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc     1920

atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cttcggctac     1980

ggcctgcagt gcttcgcccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc     2040

gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac     2100

aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag     2160

ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac     2220

agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag     2280

atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc     2340

cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcta ccagtccgcc     2400

ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc     2460

gccgggatca ctctcggcat ggacgagctg tacaagtccg gactcagatc tcgagctcaa     2520

gcttcgaatt ctgcagtcga cggtaccgcg ggcccgggat ccaccggatc tagatgataa     2580

gcatgctagc ataacccctt ggggcctcta aacgggtctt gaggggtttt ttggtttaaa     2640

cccatgtgcc tggcagataa cttcgtataa tgtatgctat acgaagttat ggtaccgcgg     2700

ccgcgtagag gatctgttga tcagcagttc aacctgttga tagtacgtac taagctctca     2760

tgtttcacgt actaagctct catgtttaac gtactaagct ctcatgttta acgaactaaa     2820

ccctcatggc taacgtacta agctctcatg gctaacgtac taagctctca tgtttcacgt     2880

actaagctct catgtttgaa caataaaatt aatataaatc agcaacttaa atagcctcta     2940

aggttttaag ttttataaga aaaaaaagaa tatataaggc ttttaaagct tttaaggttt     3000

aacggttgtg gacaacaagc cagggatgta acgcactgag aagcccttag agcctctcaa     3060

agcaattttg agtgacacag gaacacttaa cggctgacag aattagcttc acgctgccgc     3120

aagcactcag ggcgcaaggg ctgctaaagg aagcggaaca cgtagaaagc cagtccgcag     3180

aaacggtgct gaccccggat gaatgtcagc tgggaggcag aataaatgat catatcgtca     3240

attattacct ccacggggag agcctgagca aactggcctc aggcatttga gaagcacacg     3300

gtcacactgc ttccggtagt caataaaccg gtaaaccagc aatagacata agcggctatt     3360

taacgaccct gccctgaacc gacgaccggg tcgaatttgc tttcgaattt ctgccattca     3420

tccgcttatt atcacttatt caggcgtagc aaccaggcgt ttaagggcac caataactgc     3480

cttaaaaaaa tta                                                        3493


<210>  78
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human beta2-KPI-YFP_deletion

<400>  78

Met Gly Asn Thr Thr Ser Asp Arg Val Ser Gly Glu Arg His Gly Ala 
1               5                   10                  15      


Lys Ala Ala Arg Ser Glu Gly Ala Gly Gly His Ala Pro Gly Lys Glu 
            20                  25                  30          


His Lys Ile Met Val Gly Ser Thr Asp Asp Pro Ser Val Phe Ser Leu 
        35                  40                  45              


Pro Asp Ser Lys Leu Pro Gly Asp Lys Glu Phe Val Ser Trp Gln Gln 
    50                  55                  60                  


Asp Leu Glu Asp Ser Val Lys Pro Thr Gln Gln Ala Arg Pro Thr Val 
65                  70                  75                  80  


Ile Arg Trp Ser Glu Gly Gly Lys Glu Val Phe Ile Ser Gly Ser Phe 
                85                  90                  95      


Asn Asn Trp Ser Thr Lys Ile Pro Leu Ile Lys Ser His Asn Asp Phe 
            100                 105                 110         


Val Ala Ile Leu Asp Leu Pro Glu Gly Glu His Gln Tyr Lys Phe Phe 
        115                 120                 125             


Val Asp Gly Gln Trp Val His Asp Pro Ser Glu Pro Val Val Thr Ser 
    130                 135                 140                 


Gln Leu Gly Thr Ile Asn Asn Leu Ile His Val Lys Lys Ser Asp Phe 
145                 150                 155                 160 


Glu Val Phe Asp Ala Leu Lys Leu Asp Ser Met Glu Ser Ser Glu Thr 
                165                 170                 175     


Ser Cys Arg Asp Leu Ser Ser Ser Pro Pro Gly Pro Tyr Gly Gln Glu 
            180                 185                 190         


Met Tyr Ala Phe Arg Ser Glu Glu Arg Phe Lys Ser Pro Pro Ile Leu 
        195                 200                 205             


Pro Pro His Leu Leu Gln Val Ile Leu Asn Lys Asp Thr Asn Ile Ser 
    210                 215                 220                 


Cys Asp Pro Ala Leu Leu Pro Glu Pro Asn His Val Met Leu Asn His 
225                 230                 235                 240 


Leu Tyr Ala Leu Ser Ile Lys Asp Ser Val Met Val Leu Ser Ala Thr 
                245                 250                 255     


His Arg Tyr Lys Lys Lys Tyr Val Thr Thr Leu Leu Tyr Met Val Ser 
            260                 265                 270         


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
        275                 280                 285             


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
    290                 295                 300                 


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
305                 310                 315                 320 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr 
                325                 330                 335     


Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp 
            340                 345                 350         


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
        355                 360                 365             


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
    370                 375                 380                 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
385                 390                 395                 400 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
                405                 410                 415     


Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys 
            420                 425                 430         


Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu 
        435                 440                 445             


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
    450                 455                 460                 


Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp 
465                 470                 475                 480 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
                485                 490                 495     


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg 
            500                 505                 510         


Ser Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr Ala Gly Pro 
        515                 520                 525             


Gly Ser Thr Gly Ser Arg 
    530                 


<210>  79
<211>  3610
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-LTGGEKKP-YFP_deletion, pDS plasmid

<400>  79
atgagggaag cggtgatcgc cgaagtatcg actcaactat cagaggtagt tggcgtcatc       60

gagcgccatc tcgaaccgac gttgctggcc gtacatttgt acggctccgc agtggatggc      120

ggcctgaagc cacacagtga tattgatttg ctggttacgg tgaccgtaag gcttgatgaa      180

acaacgcggc gagctttgat caacgacctt ttggaaactt cggcttcccc tggagagagc      240

gagattctcc gcgctgtaga agtcaccatt gttgtgcacg acgacatcat tccgtggcgt      300

tatccagcta agcgcgaact gcaatttgga gaatggcagc gcaatgacat tcttgcaggt      360

atcttcgagc cagccacgat cgacattgat ctggctatct tgctgacaaa agcaagagaa      420

catagcgttg ccttggtagg tccagcggcg gaggaactct ttgatccggt tcctgaacag      480

gatctatttg aggcgctaaa tgaaacctta acgctatgga actcgccgcc cgactgggct      540

ggcgatgagc gaaatgtagt gcttacgttg tcccgcattt ggtacagcgc agtaaccggc      600

aaaatcgcgc cgaaggatgt cgctgccgac tgggcaatgg agcgcctgcc ggcccagtat      660

cagcccgtca tacttgaagc tagacaggct tatcttggac aagaagaaga tcgcttggcc      720

tcgcgcgcag atcagttgga agaatttgtc cactacgtga aaggcgagat caccaaggta      780

gtcggcaaat aatgtctaac aattcgttca agccgacgga tctatgtcgg gtgcggagaa      840

agaggtaatg aaatggcacc taggtatcga taatacgact cactataggg gaattgtgag      900

cggataacaa ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat      960

ggagtcggtt gctgcagaga gcgctccagc tccggagaat gaacactctc aagagacccc     1020

ggaatcgaac agtagtgtgt acaccacctt catgaagtct catcgctgct atgacctgat     1080

ccccacaagc tccaagctgg tggtatttga tacttcgctg caggtaaaga aagccttctt     1140

tgccctggtg actaacggtg ttcgtgctgc ccctttgtgg gatagtaaga agcagagctt     1200

tgtgggcatg ctgaccatca ctgacttcat caatattctg caccgatact acaagtcagc     1260

cctggtgcag atctatgaac tggaggagca caagatagag acttggagag aggtctacct     1320

gcaagactcc tttaagccac ttgtctgcat ttctccaaat gccagcttgt tcgatgctgt     1380

ctcttcatta attcgaaata agatccacag gcttccagtt attgacccgg agtcaggcaa     1440

caccttgtac attcttactc acaagcggat cctcaagttc ctcaagttgt ttatcactga     1500

gttccccaag ccggaattca tgtctaagtc tctggaagag ctacagattg gcacctacgc     1560

caatattgcc atggtccgta ccactacacc tgtctatgtg gctctgggca tctttgtaca     1620

gcaccgagtc tccgccttgc ctgtggtgga tgagaaaggg cgtgtggtgg acatctactc     1680

caagtttgat gtgattaatt tggcagcaga aaagacatac aacaacctag atgtgtctgt     1740

gacaaaagcc ctacagcacc ggtcacacta cttcgagggt gttctcaagt gctacctaca     1800

tgagactcta gaagcaatca tcaatagact ggtggaagca gaggttcacc gtctggtggt     1860

ggtggatgaa catgacgtgg tcaagggcat tgtatcgctg tctgacatct tacaggctct     1920

ggtgatggtg agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct     1980

ggacggcgac gtaaacggcc acaagttcag cgtgtccggc gagggcgagg gcgatgccac     2040

ctacggcaag ctgaccctga agttcatctg caccaccggc aagctgcccg tgccctggcc     2100

caccctcgtg accaccttcg gctacggcct gcagtgcttc gcccgctacc ccgaccacat     2160

gaagcagcac gacttcttca agtccgccat gcccgaaggc tacgtccagg agcgcaccat     2220

cttcttcaag gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac     2280

cctggtgaac cgcatcgagc tgaagggcat cgacttcaag gaggacggca acatcctggg     2340

gcacaagctg gagtacaact acaacagcca caacgtctat atcatggccg acaagcagaa     2400

gaacggcatc aaggtgaact tcaagatccg ccacaacatc gaggacggca gcgtgcagct     2460

cgccgaccac taccagcaga acacccccat cggcgacggc cccgtgctgc tgcccgacaa     2520

ccactacctg agctaccagt ccgccctgag caaagacccc aacgagaagc gcgatcacat     2580

ggtcctgctg gagttcgtga ccgccgccgg gatcactctc ggcatggacg agctgtacaa     2640

gtccggactc agatctcgag ctcaagcttc gaattctgca gtcgacggta ccgcgggccc     2700

gggatccacc ggatctagat gataactagt tccgtttaaa cccatgtgcc tggcagataa     2760

cttcgtataa tgtatgctat acgaagttat ggtacgtact aagctctcat gtttcacgta     2820

ctaagctctc atgtttaacg tactaagctc tcatgtttaa cgaactaaac cctcatggct     2880

aacgtactaa gctctcatgg ctaacgtact aagctctcat gtttcacgta ctaagctctc     2940

atgtttgaac aataaaatta atataaatca gcaacttaaa tagcctctaa ggttttaagt     3000

tttataagaa aaaaaagaat atataaggct tttaaagctt ttaaggttta acggttgtgg     3060

acaacaagcc agggatgtaa cgcactgaga agcccttaga gcctctcaaa gcaattttga     3120

gtgacacagg aacacttaac ggctgacata attcagcttc acgctgccgc aagcactcag     3180

ggcgcaaggg ctgctaaagg aagcggaaca cgtagaaagc cagtccgcag aaacggtgct     3240

gaccccggat gaatgtcagc tgggaggcag aataaatgat catatcgtca attattacct     3300

ccacggggag agcctgagca aactggcctc aggcatttga gaagcacacg gtcacactgc     3360

ttccggtagt caataaaccg gtaagtagcg tatgcgctca cgcaactggt ccagaacctt     3420

gaccgaacgc agcggtggta acggcgcagt ggcggttttc atggcttgtt atgactgttt     3480

ttttggggta cagtctatgc ctcgggcatc caagcagcaa gcgcgttacg ccgtgggtcg     3540

atgtttgatg ttatggagca gcaacgatgt tacgcagcag ggcagtcgcc ctaaaacaaa     3600

gttaaacatc                                                            3610


<210>  80
<211>  587
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rat gamma1-YFP, LTGGEKKP deletion

<400>  80

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
                325                 330                 335     


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
            340                 345                 350         


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
        355                 360                 365             


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
    370                 375                 380                 


Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His 
385                 390                 395                 400 


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
                405                 410                 415     


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
            420                 425                 430         


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
        435                 440                 445             


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
    450                 455                 460                 


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
465                 470                 475                 480 


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
                485                 490                 495     


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
            500                 505                 510         


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser 
        515                 520                 525             


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
    530                 535                 540                 


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
545                 550                 555                 560 


Lys Ser Gly Leu Arg Ser Arg Ala Gln Ala Ser Asn Ser Ala Val Asp 
                565                 570                 575     


Gly Thr Ala Gly Pro Gly Ser Thr Gly Ser Arg 
            580                 585         


<210>  81
<211>  6958
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat alpha2-AR-mseCFP-11_deletion, pACEMam2 plasmid

<400>  81
tcgagccatg gtgctagcag ctgatgcata gcatgcggta cctaattcac tcctcaggtg       60

caggctgcct atcagaaggt ggtggctggt gtggctaatg ccctggctca caaataccac      120

tgagatcttt ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg      180

acttctggct aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt      240

ctctcactcg gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg      300

gtttagagtt tggcaacata tgccatatgc tggctgccat gaacaaaggt ggctataaag      360

aggtcatcag tatatgaaac agccccctgc tgtccattcc ttattccata gaaaagcctt      420

gacttgaggt tagatttttt ttatattttg ttttgtgtta tttttttctt taacatccct      480

aaaattttcc ttacatgttt tactagccag atttttcctc ctctcctgac tactcccagt      540

catagctgtc cctcttctct tatgaagatc cctcgacgtt taaactcgct accttaggac      600

cgttatagtt acagataact tcgtataatg tatgctatac gaagttatgg cgacttcgct      660

gctgcccaag gttgccgggt gacgcacacc gtggaaacgg atgaaggcac gaacccagtt      720

gacataagcc tgttcggttc gtaaactgta atgcaagtag cgtatgcgct cacgcaactg      780

gtccagaacc ttgaccgaac gcagcggtgg taacggcgca gtggcggttt tcatggcttg      840

ttatgactgt ttttttgtac agtctatgcc tcgggcatcc aagcagcaag cgcgttacgc      900

cgtgggtcga tgtttgatgt tatggagcag caacgatgtt acgcagcagc aacgatgtta      960

cgcagcaggg cagtcgccct aaaacaaagt taggtggctc aagtatgggc atcattcgca     1020

catgtaggct cggccctgac caagtcaaat ccatgcgggc tgctcttgat cttttcggtc     1080

gtgagttcgg agacgtagcc acctactccc aacatcagcc ggactccgat tacctcggga     1140

acttgctccg tagtaagaca ttcatcgcgc ttgctgcctt cgaccaagaa gcggttgttg     1200

gcgctctcgc ggcttacgtt ctgcccaagt ttgagcagcc gcgtagtgag atctatatct     1260

atgatctcgc agtctccggc gagcaccgga ggcagggcat tgccaccgcg ctcatcaatc     1320

tcctcaagca tgaggccaac gcgcttggtg cttatgtgat ctacgtgcaa gcagattacg     1380

gtgacgatcc cgcagtggct ctctatacaa agttgggcat acgggaagaa gtgatgcact     1440

ttgatatcga cccaagtacc gccacctaac aattcgttca agccgagatc ggcttcccgg     1500

ccgcggagtt gttcggtaaa ttgtcacaac gccgcgaata tagtctttac atgcccttgg     1560

ccacgcccct ctttaatacg acgggcaatt tgcacttcag aaaatgaaga gtttgcttta     1620

gccataacaa aagtccagta tgctttttca cagcataact ggactgattt cagtttacaa     1680

ctattctgtc tagtttaaga ctttattgtc atagtttaga tctattttgt tcagtttaag     1740

actttattgt ccgcccacac ccgcttacgc agggcatctg cgcatccaca ggaagagcga     1800

cccaagtcaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     1860

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     1920

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     1980

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     2040

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     2100

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     2160

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     2220

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     2280

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     2340

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     2400

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     2460

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     2520

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     2580

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     2640

ttggtctgac agttgaccca agtcaaccgg ttgtgggcgg acaaaatagt tgggaactgg     2700

gaggggtgga aatggagttt ttaaggatta tttagggaag agtgacaaaa tagatgggaa     2760

ctgggtgtag cgtcgtaagc taatacgaaa attaaaaatg acaaaatagt ttggaactag     2820

atttcactta tctggttcca attagatgga tcgatactac gatactagta tacgttatta     2880

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata     2940

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat     3000

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga     3060

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc     3120

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt     3180

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ctcatgggtc     3240

gaggtgagcc ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt     3300

ttgtatttat ttatttttta attattttgt gcagcgatgg gggcgggggg ggggggggcg     3360

cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc     3420

ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg     3480

gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc cttcgccccg     3540

tgccccgctc cgcgccgcct cgcgccgccc gccccggctc tgactgaccg cgttactccc     3600

acaggtgagc gggcgggacg gcccttctcc tccgggctgt aattagcgct tggtttaatg     3660

acggctcgtt tcttttctgt ggctgcgtga aagccttaaa gggctccggg agggcccttt     3720

gtgcgggggg gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt     3780

gcggcccgcg ctgcccggcg gctgtgagcg ctgcgggcgc ggcgcggggc tttgtgcgct     3840

ccgcgtgtgc gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg gggggctgcg     3900

aggggaacaa aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg ggtgtgggcg     3960

cggcggtcgg gctgtaaccc ccccctgcac ccccctcccc gagttgctga gcacggcccg     4020

gcttcgggtg cggggctccg tgcggggcgt ggcgcggggc tcgccgtgcc gggcgggggg     4080

tggcggcagg tgggggtgcc gggcggggcg gggccgcctc gggccgggga gggctcgggg     4140

gaggggcgcg gcggccccgg agcgccggcg gctgtcgagg cgcggcgagc cgcagccatt     4200

gccttttatg gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa atctggcgga     4260

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcgggcgaa gcggtgcggc     4320

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     4380

ctccatctcc agcctcgggg ctgccgcagg gggacggctg ccttcggggg ggacggggca     4440

gggcggggtt cggcttctgg cgtgtgaccg gcggctgcta gagcctctgc taaccatgtt     4500

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttgttgt gctgtctcat     4560

cattttggca aagaattgcg gccgtctcag gccaccgaag acttgatcac ccgggatcat     4620

ggctgagaag cagaagcacg acgggcgtgt gaagatcgga cactacgtgc tgggggacac     4680

cctgggcgtc ggcaccttcg gcaaagtgaa gattggagaa catcaattga caggccataa     4740

agtggcagtt aagatcttaa atagacagaa gattcgcagt ttagatgttg ttggaaaaat     4800

aaaacgagaa attcaaaatc ttaaactctt tcgtcatcct catattatca aactctacca     4860

agtgatcagc actccaacag acttttttat ggtaatggaa tatgtgtctg gaggtgaatt     4920

gttcgactac atctgtaaac acgggagggt tgaagaggtg gaagctcgcc ggctcttcca     4980

gcagattctg tctgccgtgg actactgtca caggcacatg gttgtccaca gggacctgaa     5040

gccagagaac gtgttgctgg acgcccagat gaatgctaag atagctgact tcggactctc     5100

taatatgatg tcagatggtg aatttctacg aactagctgt ggatcgccaa attatgcagc     5160

accggaggtc atctcaggaa ggctgtatgc gggtcctgag gttgatatct ggagctgtgg     5220

tgttatcctg tatgcccttc tctgtggcac cctcccgttc gacgatgagc acgtgcctac     5280

gctctttaag aagatccgag ggggtgtgtt ctacatcccg gagtatctca accgttctat     5340

tgccactctg ctgatgcaca tgctgcaggt ggaccccttg aagcgagcaa ctatcaaaga     5400

catacgagag catgaatggt ttaaacagga tttgcccagt tacctctttc ctgaagaccc     5460

ctcctatgat gctaacgtca ttgatgatga ggctgtgaaa gaagtatgtg aaaaatttga     5520

gtgtacagaa tcagaagtga tgaacagttt atacagtggt gaccctcaag accagctcgc     5580

agtggcttat catctcatca ttgacaatcg gagaataatg aaccaagcca gtgagttcta     5640

cctcgcctcc agtcctccaa cgggttcctt catggacgat atggccatgc acattccccc     5700

cggcctgaaa ccacatcctg aaaggatgcc acctctcata gcagacagcc ccaaagcacg     5760

ctgtccactg gatgcactca acacaactaa gcccaaatct ttagctgtga aaaaagccaa     5820

gtggcacctt gggatccgaa gccagagcaa accatacgac attatggcgg aggtgtaccg     5880

agctatgaag cagctggact ttgaatggaa ggtagtgaat gcataccatc ttcgagtaag     5940

aagaaaaaac ccagtgactg gcaattacgt gaaaatgagc ttacagcttt acctggttga     6000

caatcggagc tatctgctgg actttaaaag catcgatgat gaggtggtgg agcagaggtc     6060

tggttcttca acacctcagc gctcctgttc tgctgccggc ctccacagac ctcggtcaag     6120

tgtcgattcc agcacagccg agaaccattc actgtctggc tctctcactg gttctttgac     6180

tggcagcact ttgtcctccg cttccccgcg cctgggcagt cataccatgg atttttttga     6240

aatgtgcgcc agtcttatca ctgctttaat ggtgagcaag ggcgaggagc tgttcaccgg     6300

ggtggtgccc atcctggtcg agctggacgg cgacgtaaac ggccacaggt tcagcgtgtc     6360

cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca tctgcaccac     6420

cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctggg gcgtgcagtg     6480

cttcgcccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg ccatgcccga     6540

aggctacgtc caggagcgta ccatcttctt caaggacgac ggcaactaca agacccgcgc     6600

cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg gcatcgactt     6660

caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacatca gccacaacgt     6720

ctatatcacc gccgacaagc agaagaacgg catcaaggcc cacttcaaga tccgccacaa     6780

catcgaggac ggcggcgtgc agctcgccga ccactaccag cagaacaccc ccatcggcga     6840

cggccccgtg ctgctgcccg acaaccacta cctgagcacc cagtccaagc tgagcaaaga     6900

ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg cctaatag       6958


<210>  82
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat alpha2-AR-mseCFP-11_deletion

<400>  82

Met Ala Glu Lys Gln Lys His Asp Gly Arg Val Lys Ile Gly His Tyr 
1               5                   10                  15      


Val Leu Gly Asp Thr Leu Gly Val Gly Thr Phe Gly Lys Val Lys Ile 
            20                  25                  30          


Gly Glu His Gln Leu Thr Gly His Lys Val Ala Val Lys Ile Leu Asn 
        35                  40                  45              


Arg Gln Lys Ile Arg Ser Leu Asp Val Val Gly Lys Ile Lys Arg Glu 
    50                  55                  60                  


Ile Gln Asn Leu Lys Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr 
65                  70                  75                  80  


Gln Val Ile Ser Thr Pro Thr Asp Phe Phe Met Val Met Glu Tyr Val 
                85                  90                  95      


Ser Gly Gly Glu Leu Phe Asp Tyr Ile Cys Lys His Gly Arg Val Glu 
            100                 105                 110         


Glu Val Glu Ala Arg Arg Leu Phe Gln Gln Ile Leu Ser Ala Val Asp 
        115                 120                 125             


Tyr Cys His Arg His Met Val Val His Arg Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Val Leu Leu Asp Ala Gln Met Asn Ala Lys Ile Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ser Asn Met Met Ser Asp Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser 
                165                 170                 175     


Pro Asn Tyr Ala Ala Pro Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly 
            180                 185                 190         


Pro Glu Val Asp Ile Trp Ser Cys Gly Val Ile Leu Tyr Ala Leu Leu 
        195                 200                 205             


Cys Gly Thr Leu Pro Phe Asp Asp Glu His Val Pro Thr Leu Phe Lys 
    210                 215                 220                 


Lys Ile Arg Gly Gly Val Phe Tyr Ile Pro Glu Tyr Leu Asn Arg Ser 
225                 230                 235                 240 


Ile Ala Thr Leu Leu Met His Met Leu Gln Val Asp Pro Leu Lys Arg 
                245                 250                 255     


Ala Thr Ile Lys Asp Ile Arg Glu His Glu Trp Phe Lys Gln Asp Leu 
            260                 265                 270         


Pro Ser Tyr Leu Phe Pro Glu Asp Pro Ser Tyr Asp Ala Asn Val Ile 
        275                 280                 285             


Asp Asp Glu Ala Val Lys Glu Val Cys Glu Lys Phe Glu Cys Thr Glu 
    290                 295                 300                 


Ser Glu Val Met Asn Ser Leu Tyr Ser Gly Asp Pro Gln Asp Gln Leu 
305                 310                 315                 320 


Ala Val Ala Tyr His Leu Ile Ile Asp Asn Arg Arg Ile Met Asn Gln 
                325                 330                 335     


Ala Ser Glu Phe Tyr Leu Ala Ser Ser Pro Pro Thr Gly Ser Phe Met 
            340                 345                 350         


Asp Asp Met Ala Met His Ile Pro Pro Gly Leu Lys Pro His Pro Glu 
        355                 360                 365             


Arg Met Pro Pro Leu Ile Ala Asp Ser Pro Lys Ala Arg Cys Pro Leu 
    370                 375                 380                 


Asp Ala Leu Asn Thr Thr Lys Pro Lys Ser Leu Ala Val Lys Lys Ala 
385                 390                 395                 400 


Lys Trp His Leu Gly Ile Arg Ser Gln Ser Lys Pro Tyr Asp Ile Met 
                405                 410                 415     


Ala Glu Val Tyr Arg Ala Met Lys Gln Leu Asp Phe Glu Trp Lys Val 
            420                 425                 430         


Val Asn Ala Tyr His Leu Arg Val Arg Arg Lys Asn Pro Val Thr Gly 
        435                 440                 445             


Asn Tyr Val Lys Met Ser Leu Gln Leu Tyr Leu Val Asp Asn Arg Ser 
    450                 455                 460                 


Tyr Leu Leu Asp Phe Lys Ser Ile Asp Asp Glu Val Val Glu Gln Arg 
465                 470                 475                 480 


Ser Gly Ser Ser Thr Pro Gln Arg Ser Cys Ser Ala Ala Gly Leu His 
                485                 490                 495     


Arg Pro Arg Ser Ser Val Asp Ser Ser Thr Ala Glu Asn His Ser Leu 
            500                 505                 510         


Ser Gly Ser Leu Thr Gly Ser Leu Thr Gly Ser Thr Leu Ser Ser Ala 
        515                 520                 525             


Ser Pro Arg Leu Gly Ser His Thr Met Asp Phe Phe Glu Met Cys Ala 
    530                 535                 540                 


Ser Leu Ile Thr Ala Leu Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
545                 550                 555                 560 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
                565                 570                 575     


Arg Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
            580                 585                 590         


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
        595                 600                 605             


Pro Thr Leu Val Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ala Arg 
    610                 615                 620                 


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
625                 630                 635                 640 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
                645                 650                 655     


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
            660                 665                 670         


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
        675                 680                 685             


Gly His Lys Leu Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile Thr 
    690                 695                 700                 


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala His Phe Lys Ile Arg His 
705                 710                 715                 720 


Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
                725                 730                 735     


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
            740                 745                 750         


Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
        755                 760                 765             


Met Val Leu Leu Glu Phe Val Thr Ala Ala 
    770                 775             


<210>  83
<211>  6970
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat alpha2-AR_helix_-MVSKmseCFP-11_deletion, pACEMam2 plasmid

<400>  83
tcgagccatg gtgctagcag ctgatgcata gcatgcggta cctaattcac tcctcaggtg       60

caggctgcct atcagaaggt ggtggctggt gtggctaatg ccctggctca caaataccac      120

tgagatcttt ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg      180

acttctggct aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt      240

ctctcactcg gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg      300

gtttagagtt tggcaacata tgccatatgc tggctgccat gaacaaaggt ggctataaag      360

aggtcatcag tatatgaaac agccccctgc tgtccattcc ttattccata gaaaagcctt      420

gacttgaggt tagatttttt ttatattttg ttttgtgtta tttttttctt taacatccct      480

aaaattttcc ttacatgttt tactagccag atttttcctc ctctcctgac tactcccagt      540

catagctgtc cctcttctct tatgaagatc cctcgacgtt taaactcgct accttaggac      600

cgttatagtt acagataact tcgtataatg tatgctatac gaagttatgg cgacttcgct      660

gctgcccaag gttgccgggt gacgcacacc gtggaaacgg atgaaggcac gaacccagtt      720

gacataagcc tgttcggttc gtaaactgta atgcaagtag cgtatgcgct cacgcaactg      780

gtccagaacc ttgaccgaac gcagcggtgg taacggcgca gtggcggttt tcatggcttg      840

ttatgactgt ttttttgtac agtctatgcc tcgggcatcc aagcagcaag cgcgttacgc      900

cgtgggtcga tgtttgatgt tatggagcag caacgatgtt acgcagcagc aacgatgtta      960

cgcagcaggg cagtcgccct aaaacaaagt taggtggctc aagtatgggc atcattcgca     1020

catgtaggct cggccctgac caagtcaaat ccatgcgggc tgctcttgat cttttcggtc     1080

gtgagttcgg agacgtagcc acctactccc aacatcagcc ggactccgat tacctcggga     1140

acttgctccg tagtaagaca ttcatcgcgc ttgctgcctt cgaccaagaa gcggttgttg     1200

gcgctctcgc ggcttacgtt ctgcccaagt ttgagcagcc gcgtagtgag atctatatct     1260

atgatctcgc agtctccggc gagcaccgga ggcagggcat tgccaccgcg ctcatcaatc     1320

tcctcaagca tgaggccaac gcgcttggtg cttatgtgat ctacgtgcaa gcagattacg     1380

gtgacgatcc cgcagtggct ctctatacaa agttgggcat acgggaagaa gtgatgcact     1440

ttgatatcga cccaagtacc gccacctaac aattcgttca agccgagatc ggcttcccgg     1500

ccgcggagtt gttcggtaaa ttgtcacaac gccgcgaata tagtctttac atgcccttgg     1560

ccacgcccct ctttaatacg acgggcaatt tgcacttcag aaaatgaaga gtttgcttta     1620

gccataacaa aagtccagta tgctttttca cagcataact ggactgattt cagtttacaa     1680

ctattctgtc tagtttaaga ctttattgtc atagtttaga tctattttgt tcagtttaag     1740

actttattgt ccgcccacac ccgcttacgc agggcatctg cgcatccaca ggaagagcga     1800

cccaagtcaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     1860

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     1920

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     1980

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     2040

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     2100

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     2160

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     2220

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     2280

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     2340

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     2400

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     2460

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     2520

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     2580

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     2640

ttggtctgac agttgaccca agtcaaccgg ttgtgggcgg acaaaatagt tgggaactgg     2700

gaggggtgga aatggagttt ttaaggatta tttagggaag agtgacaaaa tagatgggaa     2760

ctgggtgtag cgtcgtaagc taatacgaaa attaaaaatg acaaaatagt ttggaactag     2820

atttcactta tctggttcca attagatgga tcgatactac gatactagta tacgttatta     2880

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata     2940

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat     3000

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga     3060

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc     3120

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt     3180

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ctcatgggtc     3240

gaggtgagcc ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt     3300

ttgtatttat ttatttttta attattttgt gcagcgatgg gggcgggggg ggggggggcg     3360

cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc     3420

ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg     3480

gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc cttcgccccg     3540

tgccccgctc cgcgccgcct cgcgccgccc gccccggctc tgactgaccg cgttactccc     3600

acaggtgagc gggcgggacg gcccttctcc tccgggctgt aattagcgct tggtttaatg     3660

acggctcgtt tcttttctgt ggctgcgtga aagccttaaa gggctccggg agggcccttt     3720

gtgcgggggg gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt     3780

gcggcccgcg ctgcccggcg gctgtgagcg ctgcgggcgc ggcgcggggc tttgtgcgct     3840

ccgcgtgtgc gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg gggggctgcg     3900

aggggaacaa aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg ggtgtgggcg     3960

cggcggtcgg gctgtaaccc ccccctgcac ccccctcccc gagttgctga gcacggcccg     4020

gcttcgggtg cggggctccg tgcggggcgt ggcgcggggc tcgccgtgcc gggcgggggg     4080

tggcggcagg tgggggtgcc gggcggggcg gggccgcctc gggccgggga gggctcgggg     4140

gaggggcgcg gcggccccgg agcgccggcg gctgtcgagg cgcggcgagc cgcagccatt     4200

gccttttatg gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa atctggcgga     4260

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcgggcgaa gcggtgcggc     4320

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     4380

ctccatctcc agcctcgggg ctgccgcagg gggacggctg ccttcggggg ggacggggca     4440

gggcggggtt cggcttctgg cgtgtgaccg gcggctgcta gagcctctgc taaccatgtt     4500

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttgttgt gctgtctcat     4560

cattttggca aagaattgcg gccgtctcag gccaccgaag acttgatcac ccgggatcat     4620

ggctgagaag cagaagcacg acgggcgtgt gaagatcgga cactacgtgc tgggggacac     4680

cctgggcgtc ggcaccttcg gcaaagtgaa gattggagaa catcaattga caggccataa     4740

agtggcagtt aagatcttaa atagacagaa gattcgcagt ttagatgttg ttggaaaaat     4800

aaaacgagaa attcaaaatc ttaaactctt tcgtcatcct catattatca aactctacca     4860

agtgatcagc actccaacag acttttttat ggtaatggaa tatgtgtctg gaggtgaatt     4920

gttcgactac atctgtaaac acgggagggt tgaagaggtg gaagctcgcc ggctcttcca     4980

gcagattctg tctgccgtgg actactgtca caggcacatg gttgtccaca gggacctgaa     5040

gccagagaac gtgttgctgg acgcccagat gaatgctaag atagctgact tcggactctc     5100

taatatgatg tcagatggtg aatttctacg aactagctgt ggatcgccaa attatgcagc     5160

accggaggtc atctcaggaa ggctgtatgc gggtcctgag gttgatatct ggagctgtgg     5220

tgttatcctg tatgcccttc tctgtggcac cctcccgttc gacgatgagc acgtgcctac     5280

gctctttaag aagatccgag ggggtgtgtt ctacatcccg gagtatctca accgttctat     5340

tgccactctg ctgatgcaca tgctgcaggt ggaccccttg aagcgagcaa ctatcaaaga     5400

catacgagag catgaatggt ttaaacagga tttgcccagt tacctctttc ctgaagaccc     5460

ctcctatgat gctaacgtca ttgatgatga ggctgtgaaa gaagtatgtg aaaaatttga     5520

gtgtacagaa tcagaagtga tgaacagttt atacagtggt gaccctcaag accagctcgc     5580

agtggcttat catctcatca ttgacaatcg gagaataatg aaccaagcca gtgagttcta     5640

cctcgcctcc agtcctccaa cgggttcctt catggacgat atggccatgc acattccccc     5700

cggcctgaaa ccacatcctg aaaggatgcc acctctcata gcagacagcc ccaaagcacg     5760

ctgtccactg gatgcactca acacaactaa gcccaaatct ttagctgtga aaaaagccaa     5820

gtggcacctt gggatccgaa gccagagcaa accatacgac attatggcgg aggtgtaccg     5880

agctatgaag cagctggact ttgaatggaa ggtagtgaat gcataccatc ttcgagtaag     5940

aagaaaaaac ccagtgactg gcaattacgt gaaaatgagc ttacagcttt acctggttga     6000

caatcggagc tatctgctgg actttaaaag catcgatgat gaggtggtgg agcagaggtc     6060

tggttcttca acacctcagc gctcctgttc tgctgccggc ctccacagac ctcggtcaag     6120

tgtcgattcc agcacagccg agaaccattc actgtctggc tctctcactg gttctttgac     6180

tggcagcact ttgtcctccg cttccccgcg cctgggcagt cataccatgg atttttttga     6240

aatgtgcgcc agtcttatca ctgctttaga ggaggaagag aagaaaaaga aaggcgagga     6300

gctgttcacc ggggtggtgc ccatcctggt cgagctggac ggcgacgtaa acggccacag     6360

gttcagcgtg tccggcgagg gcgagggcga tgccacctac ggcaagctga ccctgaagtt     6420

catctgcacc accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca ccctgacctg     6480

gggcgtgcag tgcttcgccc gctaccccga ccacatgaag cagcacgact tcttcaagtc     6540

cgccatgccc gaaggctacg tccaggagcg taccatcttc ttcaaggacg acggcaacta     6600

caagacccgc gccgaggtga agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa     6660

gggcatcgac ttcaaggagg acggcaacat cctggggcac aagctggagt acaactacat     6720

cagccacaac gtctatatca ccgccgacaa gcagaagaac ggcatcaagg cccacttcaa     6780

gatccgccac aacatcgagg acggcggcgt gcagctcgcc gaccactacc agcagaacac     6840

ccccatcggc gacggccccg tgctgctgcc cgacaaccac tacctgagca cccagtccaa     6900

gctgagcaaa gaccccaacg agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc     6960

cgcctaatag                                                            6970


<210>  84
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat alpha2-AR_helix_-MVSKmseCFP-11_deletion

<400>  84

Met Ala Glu Lys Gln Lys His Asp Gly Arg Val Lys Ile Gly His Tyr 
1               5                   10                  15      


Val Leu Gly Asp Thr Leu Gly Val Gly Thr Phe Gly Lys Val Lys Ile 
            20                  25                  30          


Gly Glu His Gln Leu Thr Gly His Lys Val Ala Val Lys Ile Leu Asn 
        35                  40                  45              


Arg Gln Lys Ile Arg Ser Leu Asp Val Val Gly Lys Ile Lys Arg Glu 
    50                  55                  60                  


Ile Gln Asn Leu Lys Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr 
65                  70                  75                  80  


Gln Val Ile Ser Thr Pro Thr Asp Phe Phe Met Val Met Glu Tyr Val 
                85                  90                  95      


Ser Gly Gly Glu Leu Phe Asp Tyr Ile Cys Lys His Gly Arg Val Glu 
            100                 105                 110         


Glu Val Glu Ala Arg Arg Leu Phe Gln Gln Ile Leu Ser Ala Val Asp 
        115                 120                 125             


Tyr Cys His Arg His Met Val Val His Arg Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Val Leu Leu Asp Ala Gln Met Asn Ala Lys Ile Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ser Asn Met Met Ser Asp Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser 
                165                 170                 175     


Pro Asn Tyr Ala Ala Pro Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly 
            180                 185                 190         


Pro Glu Val Asp Ile Trp Ser Cys Gly Val Ile Leu Tyr Ala Leu Leu 
        195                 200                 205             


Cys Gly Thr Leu Pro Phe Asp Asp Glu His Val Pro Thr Leu Phe Lys 
    210                 215                 220                 


Lys Ile Arg Gly Gly Val Phe Tyr Ile Pro Glu Tyr Leu Asn Arg Ser 
225                 230                 235                 240 


Ile Ala Thr Leu Leu Met His Met Leu Gln Val Asp Pro Leu Lys Arg 
                245                 250                 255     


Ala Thr Ile Lys Asp Ile Arg Glu His Glu Trp Phe Lys Gln Asp Leu 
            260                 265                 270         


Pro Ser Tyr Leu Phe Pro Glu Asp Pro Ser Tyr Asp Ala Asn Val Ile 
        275                 280                 285             


Asp Asp Glu Ala Val Lys Glu Val Cys Glu Lys Phe Glu Cys Thr Glu 
    290                 295                 300                 


Ser Glu Val Met Asn Ser Leu Tyr Ser Gly Asp Pro Gln Asp Gln Leu 
305                 310                 315                 320 


Ala Val Ala Tyr His Leu Ile Ile Asp Asn Arg Arg Ile Met Asn Gln 
                325                 330                 335     


Ala Ser Glu Phe Tyr Leu Ala Ser Ser Pro Pro Thr Gly Ser Phe Met 
            340                 345                 350         


Asp Asp Met Ala Met His Ile Pro Pro Gly Leu Lys Pro His Pro Glu 
        355                 360                 365             


Arg Met Pro Pro Leu Ile Ala Asp Ser Pro Lys Ala Arg Cys Pro Leu 
    370                 375                 380                 


Asp Ala Leu Asn Thr Thr Lys Pro Lys Ser Leu Ala Val Lys Lys Ala 
385                 390                 395                 400 


Lys Trp His Leu Gly Ile Arg Ser Gln Ser Lys Pro Tyr Asp Ile Met 
                405                 410                 415     


Ala Glu Val Tyr Arg Ala Met Lys Gln Leu Asp Phe Glu Trp Lys Val 
            420                 425                 430         


Val Asn Ala Tyr His Leu Arg Val Arg Arg Lys Asn Pro Val Thr Gly 
        435                 440                 445             


Asn Tyr Val Lys Met Ser Leu Gln Leu Tyr Leu Val Asp Asn Arg Ser 
    450                 455                 460                 


Tyr Leu Leu Asp Phe Lys Ser Ile Asp Asp Glu Val Val Glu Gln Arg 
465                 470                 475                 480 


Ser Gly Ser Ser Thr Pro Gln Arg Ser Cys Ser Ala Ala Gly Leu His 
                485                 490                 495     


Arg Pro Arg Ser Ser Val Asp Ser Ser Thr Ala Glu Asn His Ser Leu 
            500                 505                 510         


Ser Gly Ser Leu Thr Gly Ser Leu Thr Gly Ser Thr Leu Ser Ser Ala 
        515                 520                 525             


Ser Pro Arg Leu Gly Ser His Thr Met Asp Phe Phe Glu Met Cys Ala 
    530                 535                 540                 


Ser Leu Ile Thr Ala Leu Glu Glu Glu Glu Lys Lys Lys Lys Gly Glu 
545                 550                 555                 560 


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
                565                 570                 575     


Val Asn Gly His Arg Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
            580                 585                 590         


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
        595                 600                 605             


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Trp Gly Val Gln 
    610                 615                 620                 


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
625                 630                 635                 640 


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
                645                 650                 655     


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
            660                 665                 670         


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
        675                 680                 685             


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Ile Ser His Asn 
    690                 695                 700                 


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala His Phe 
705                 710                 715                 720 


Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His 
                725                 730                 735     


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
            740                 745                 750         


Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu 
        755                 760                 765             


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
    770                 775                 780         


<210>  85
<211>  826
<212>  PRT
<213>  Rat a2-AR_helix_-MVSKeCFP_deletion+helix

<400>  85

Met Gly Ser Ser His His His His His His His His His His Ser Ser 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly His Met Ala Glu Lys Gln Lys His Asp 
            20                  25                  30          


Gly Arg Val Lys Ile Gly His Tyr Val Leu Gly Asp Thr Leu Gly Val 
        35                  40                  45              


Gly Thr Phe Gly Lys Val Lys Ile Gly Glu His Gln Leu Thr Gly His 
    50                  55                  60                  


Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg Ser Leu Asp 
65                  70                  75                  80  


Val Val Gly Lys Ile Lys Arg Glu Ile Gln Asn Leu Lys Leu Phe Arg 
                85                  90                  95      


His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr Pro Thr Asp 
            100                 105                 110         


Phe Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu Phe Asp Tyr 
        115                 120                 125             


Ile Cys Lys His Gly Arg Val Glu Glu Val Glu Ala Arg Arg Leu Phe 
    130                 135                 140                 


Gln Gln Ile Leu Ser Ala Val Asp Tyr Cys His Arg His Met Val Val 
145                 150                 155                 160 


His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala Gln Met Asn 
                165                 170                 175     


Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser Asp Gly Glu 
            180                 185                 190         


Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala Pro Glu Val 
        195                 200                 205             


Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile Trp Ser Cys 
    210                 215                 220                 


Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro Phe Asp Asp 
225                 230                 235                 240 


Glu His Val Pro Thr Leu Phe Lys Lys Ile Arg Gly Gly Val Phe Tyr 
                245                 250                 255     


Ile Pro Glu Tyr Leu Asn Arg Ser Ile Ala Thr Leu Leu Met His Met 
            260                 265                 270         


Leu Gln Val Asp Pro Leu Lys Arg Ala Thr Ile Lys Asp Ile Arg Glu 
        275                 280                 285             


His Glu Trp Phe Lys Gln Asp Leu Pro Ser Tyr Leu Phe Pro Glu Asp 
    290                 295                 300                 


Pro Ser Tyr Asp Ala Asn Val Ile Asp Asp Glu Ala Val Lys Glu Val 
305                 310                 315                 320 


Cys Glu Lys Phe Glu Cys Thr Glu Ser Glu Val Met Asn Ser Leu Tyr 
                325                 330                 335     


Ser Gly Asp Pro Gln Asp Gln Leu Ala Val Ala Tyr His Leu Ile Ile 
            340                 345                 350         


Asp Asn Arg Arg Ile Met Asn Gln Ala Ser Glu Phe Tyr Leu Ala Ser 
        355                 360                 365             


Ser Pro Pro Thr Gly Ser Phe Met Asp Asp Met Ala Met His Ile Pro 
    370                 375                 380                 


Pro Gly Leu Lys Pro His Pro Glu Arg Met Pro Pro Leu Ile Ala Asp 
385                 390                 395                 400 


Ser Pro Lys Ala Arg Cys Pro Leu Asp Ala Leu Asn Thr Thr Lys Pro 
                405                 410                 415     


Lys Ser Leu Ala Val Lys Lys Ala Lys Trp His Leu Gly Ile Arg Ser 
            420                 425                 430         


Gln Ser Lys Pro Tyr Asp Ile Met Ala Glu Val Tyr Arg Ala Met Lys 
        435                 440                 445             


Gln Leu Asp Phe Glu Trp Lys Val Val Asn Ala Tyr His Leu Arg Val 
    450                 455                 460                 


Arg Arg Lys Asn Pro Val Thr Gly Asn Tyr Val Lys Met Ser Leu Gln 
465                 470                 475                 480 


Leu Tyr Leu Val Asp Asn Arg Ser Tyr Leu Leu Asp Phe Lys Ser Ile 
                485                 490                 495     


Asp Asp Glu Val Val Glu Gln Arg Ser Gly Ser Ser Thr Pro Gln Arg 
            500                 505                 510         


Ser Cys Ser Ala Ala Gly Leu His Arg Pro Arg Ser Ser Val Asp Ser 
        515                 520                 525             


Ser Thr Ala Glu Asn His Ser Leu Ser Gly Ser Leu Thr Gly Ser Leu 
    530                 535                 540                 


Thr Gly Ser Thr Leu Ser Ser Ala Ser Pro Arg Leu Gly Ser His Thr 
545                 550                 555                 560 


Met Asp Phe Phe Glu Met Cys Ala Ser Leu Ile Thr Ala Leu Glu Glu 
                565                 570                 575     


Glu Glu Lys Lys Lys Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
            580                 585                 590         


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
        595                 600                 605             


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
    610                 615                 620                 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
625                 630                 635                 640 


Thr Thr Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
                645                 650                 655     


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
            660                 665                 670         


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
        675                 680                 685             


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
    690                 695                 700                 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
705                 710                 715                 720 


Glu Tyr Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln 
                725                 730                 735     


Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
            740                 745                 750         


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
        755                 760                 765             


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
    770                 775                 780                 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
785                 790                 795                 800 


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
                805                 810                 815     


Lys Ser Gly Leu Arg Ser Arg Arg Ala His 
            820                 825     


<210>  86
<211>  4949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human beta2, pMDK plasmid

<400>  86
tcgagccatg gtgctagcag ctgatgcata gcatgcggta cctaattcac tcctcaggtg       60

caggctgcct atcagaaggt ggtggctggt gtggctaatg ccctggctca caaataccac      120

tgagatcttt ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg      180

acttctggct aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt      240

ctctcactcg gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg      300

gtttagagtt tggcaacata tgccatatgc tggctgccat gaacaaaggt ggctataaag      360

aggtcatcag tatatgaaac agccccctgc tgtccattcc ttattccata gaaaagcctt      420

gacttgaggt tagatttttt ttatattttg ttttgtgtta tttttttctt taacatccct      480

aaaattttcc ttacatgttt tactagccag atttttcctc ctctcctgac tactcccagt      540

catagctgtc cctcttctct tatgaagatc cctcgacgtt taaacccatg tgcctggcag      600

ataacttcgt ataatgtatg ctatacgaag ttatggtacg tactaagctc tcatgtttca      660

cgtactaagc tctcatgttt aacgtactaa gctctcatgt ttaacgaact aaaccctcat      720

ggctaacgta ctaagctctc atggctaacg tactaagctc tcatgtttca cgtactaagc      780

tctcatgttt gaacaataaa attaatataa atcagcaact taaatagcct ctaaggtttt      840

aagttttata agaaaaaaaa gaatatataa ggcttttaaa gcttttaagg tttaacggtt      900

gtggacaaca agccagggat gtaacgcact gagaagccct tagagcctct caaagcaatt      960

ttcagtgaca caggaacact taacggctga cagaattagc ttcacgctgc cgcaagcact     1020

cagggcgcaa gggctgctaa aggaagcgga acacgtagaa agccagtccg cagaaacggt     1080

gctgaccccg gatgaatgtc agctactggg ctatctggac aagggaaaac gcaagcgcaa     1140

agagaaagca ggtagcttgc agtgggctta catggcgata gctagactgg gcggttttat     1200

ggacagcaag cgaaccggaa ttgccagctg gggcgccctc tggtaaggtt gggaagccct     1260

gcaaagtaaa ctggatggct ttcttgccgc caaggatctg atggcgcagg ggatcaagat     1320

ctgatcaaga gacaggatga ggatcgtttc gcatgattga acaagatgga ttgcacgcag     1380

gttctccggc cgcttgggtg gagaggctat tcggctatga ctgggcacaa cagacaatcg     1440

gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca     1500

agaccgacct gtccggtgcc ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc     1560

tggccacgac gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg     1620

actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac cttgctcctg     1680

ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt gatccggcta     1740

cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact cggatggaag     1800

ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg ccagccgaac     1860

tgttcgccag gctcaaggcg cgcatgcccg acggcgagga tctcgtcgtg acacatggcg     1920

atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc atcgactgtg     1980

gccggctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt gatattgctg     2040

aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc gccgctcccg     2100

attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgagcg ggactctggg     2160

gttcgaaatg accgaccaag cgacgcccaa cctgccatca cgagatttcg attccaccgc     2220

cgccttctat gaaaggttgg gcttcggaat cgttttccgg gacgccggct ggatgatcct     2280

ccagcgcggg gatctcatgc tggagttctt cgcccacccc gggatctatg tcgggtgcgg     2340

agaaagaggt aatgaaatgg cacctaggta tcgatactag tatacgttat taatagtaat     2400

caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg     2460

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt     2520

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gactatttac     2580

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg     2640

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact     2700

ttcctacttg gcagtacatc tacgtattag tcatcgctat tactcatggg tcgaggtgag     2760

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt     2820

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag     2880

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca     2940

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct     3000

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgtt gccttcgccc cgtgccccgc     3060

tccgcgccgc ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga     3120

gcgggcggga cggcccttct cctccgggct gtaattagcg cttggtttaa tgacggctcg     3180

tttcttttct gtggctgcgt gaaagcctta aagggctccg ggagggccct ttgtgcgggg     3240

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggcccg     3300

cgctgcccgg cggctgtgag cgctgcgggc gcggcgcggg gctttgtgcg ctccgcgtgt     3360

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc gggggggctg cgaggggaac     3420

aaaggctgcg tgcggggtgt gtgcgtgggg gggtgagcag ggggtgtggg cgcggcggtc     3480

gggctgtaac ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     3540

tgcggggctc cgtgcggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     3600

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     3660

cggcggcccc ggagcgccgg cggctgtcga ggcgcggcga gccgcagcca ttgcctttta     3720

tggtaatcgt gcgagagggc gcagggactt cctttgtccc aaatctggcg gagccgaaat     3780

ctgggaggcg ccgccgcacc ccctctagcg ggcgcgggcg aagcggtgcg gcgccggcag     3840

gaaggaaatg ggcggggagg gccttcgtgc gtcgccgcgc cgccgtcccc ttctccatct     3900

ccagcctcgg ggctgccgca gggggacggc tgccttcggg ggggacgggg cagggcgggg     3960

ttcggcttct ggcgtgtgac cggcggctgc tagagcctct gctaaccatg ttcatgcctt     4020

cttctttttc ctacagctcc tgggcaacgt gctggttgtt gtgctgtctc atcattttgg     4080

caaagaattg cggccgtctc aggccaccga agacttgatc acccgggatc atgggaaaca     4140

ccaccagcga ccgggtgtcc ggggagcgcc acggcgccaa ggctgcacgc tccgagggcg     4200

caggcggcca tgccccgggg aaggagcaca agatcatggt ggggagtacg gacgacccca     4260

gcgtgttcag cctccctgac tccaagctcc ctggggacaa agagtttgta tcatggcagc     4320

aggatttgga ggactccgta aagcccacac agcaggcccg gcccactgtt atccgctggt     4380

ctgaaggagg caaggaggtc ttcatctctg ggtccttcaa caattggagc gccaagattc     4440

cactgattaa gagccataat gactttgttg ccatcctgga cctccctgag ggagagcacc     4500

aatacaagtt ctttgtggat ggacagtggg ttcatgatcc atcagagcct gtggttacca     4560

gtcagcttgg cacaattaac aatttgatcc atgtcaagaa atctgatttt gaggtgttcg     4620

atgctttaaa gttagattct atggaaagtt ctgagacatc ttgtagagac ctttccagct     4680

cacccccagg gccttatggt caagaaatgt atgcgtttcg atctgaggaa agattcaaat     4740

ccccacccat ccttcctcct catctacttc aagttattct taacaaagac actaatattt     4800

cttgtgaccc agccttactc cctgagccca accatgttat gctgaaccat ctctatgcat     4860

tgtccattaa ggacagtgtg atggtcctta gcgcaaccca tcgctacaag aagaagtatg     4920

ttactactct gctatacaag cccatttaa                                       4949


<210>  87
<211>  272
<212>  PRT
<213>  Rattus norvegicus

<400>  87

Met Gly Asn Thr Thr Ser Asp Arg Val Ser Gly Glu Arg His Gly Ala 
1               5                   10                  15      


Lys Ala Ala Arg Ser Glu Gly Ala Gly Gly His Ala Pro Gly Lys Glu 
            20                  25                  30          


His Lys Ile Met Val Gly Ser Thr Asp Asp Pro Ser Val Phe Ser Leu 
        35                  40                  45              


Pro Asp Ser Lys Leu Pro Gly Asp Lys Glu Phe Val Ser Trp Gln Gln 
    50                  55                  60                  


Asp Leu Glu Asp Ser Val Lys Pro Thr Gln Gln Ala Arg Pro Thr Val 
65                  70                  75                  80  


Ile Arg Trp Ser Glu Gly Gly Lys Glu Val Phe Ile Ser Gly Ser Phe 
                85                  90                  95      


Asn Asn Trp Ser Ala Lys Ile Pro Leu Ile Lys Ser His Asn Asp Phe 
            100                 105                 110         


Val Ala Ile Leu Asp Leu Pro Glu Gly Glu His Gln Tyr Lys Phe Phe 
        115                 120                 125             


Val Asp Gly Gln Trp Val His Asp Pro Ser Glu Pro Val Val Thr Ser 
    130                 135                 140                 


Gln Leu Gly Thr Ile Asn Asn Leu Ile His Val Lys Lys Ser Asp Phe 
145                 150                 155                 160 


Glu Val Phe Asp Ala Leu Lys Leu Asp Ser Met Glu Ser Ser Glu Thr 
                165                 170                 175     


Ser Cys Arg Asp Leu Ser Ser Ser Pro Pro Gly Pro Tyr Gly Gln Glu 
            180                 185                 190         


Met Tyr Ala Phe Arg Ser Glu Glu Arg Phe Lys Ser Pro Pro Ile Leu 
        195                 200                 205             


Pro Pro His Leu Leu Gln Val Ile Leu Asn Lys Asp Thr Asn Ile Ser 
    210                 215                 220                 


Cys Asp Pro Ala Leu Leu Pro Glu Pro Asn His Val Met Leu Asn His 
225                 230                 235                 240 


Leu Tyr Ala Leu Ser Ile Lys Asp Ser Val Met Val Leu Ser Ala Thr 
                245                 250                 255     


His Arg Tyr Lys Lys Lys Tyr Val Thr Thr Leu Leu Tyr Lys Pro Ile 
            260                 265                 270         


<210>  88
<211>  5675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human beta2-KPI-cpVenus_deletion, pMDK plasmid

<400>  88
tcgagccatg gtgctagcag ctgatgcata gcatgcggta cctaattcac tcctcaggtg       60

caggctgcct atcagaaggt ggtggctggt gtggctaatg ccctggctca caaataccac      120

tgagatcttt ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg      180

acttctggct aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt      240

ctctcactcg gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg      300

gtttagagtt tggcaacata tgccatatgc tggctgccat gaacaaaggt ggctataaag      360

aggtcatcag tatatgaaac agccccctgc tgtccattcc ttattccata gaaaagcctt      420

gacttgaggt tagatttttt ttatattttg ttttgtgtta tttttttctt taacatccct      480

aaaattttcc ttacatgttt tactagccag atttttcctc ctctcctgac tactcccagt      540

catagctgtc cctcttctct tatgaagatc cctcgacgtt taaacccatg tgcctggcag      600

ataacttcgt ataatgtatg ctatacgaag ttatggtacg tactaagctc tcatgtttca      660

cgtactaagc tctcatgttt aacgtactaa gctctcatgt ttaacgaact aaaccctcat      720

ggctaacgta ctaagctctc atggctaacg tactaagctc tcatgtttca cgtactaagc      780

tctcatgttt gaacaataaa attaatataa atcagcaact taaatagcct ctaaggtttt      840

aagttttata agaaaaaaaa gaatatataa ggcttttaaa gcttttaagg tttaacggtt      900

gtggacaaca agccagggat gtaacgcact gagaagccct tagagcctct caaagcaatt      960

ttcagtgaca caggaacact taacggctga cagaattagc ttcacgctgc cgcaagcact     1020

cagggcgcaa gggctgctaa aggaagcgga acacgtagaa agccagtccg cagaaacggt     1080

gctgaccccg gatgaatgtc agctactggg ctatctggac aagggaaaac gcaagcgcaa     1140

agagaaagca ggtagcttgc agtgggctta catggcgata gctagactgg gcggttttat     1200

ggacagcaag cgaaccggaa ttgccagctg gggcgccctc tggtaaggtt gggaagccct     1260

gcaaagtaaa ctggatggct ttcttgccgc caaggatctg atggcgcagg ggatcaagat     1320

ctgatcaaga gacaggatga ggatcgtttc gcatgattga acaagatgga ttgcacgcag     1380

gttctccggc cgcttgggtg gagaggctat tcggctatga ctgggcacaa cagacaatcg     1440

gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca     1500

agaccgacct gtccggtgcc ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc     1560

tggccacgac gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg     1620

actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac cttgctcctg     1680

ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt gatccggcta     1740

cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact cggatggaag     1800

ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg ccagccgaac     1860

tgttcgccag gctcaaggcg cgcatgcccg acggcgagga tctcgtcgtg acacatggcg     1920

atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc atcgactgtg     1980

gccggctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt gatattgctg     2040

aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc gccgctcccg     2100

attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgagcg ggactctggg     2160

gttcgaaatg accgaccaag cgacgcccaa cctgccatca cgagatttcg attccaccgc     2220

cgccttctat gaaaggttgg gcttcggaat cgttttccgg gacgccggct ggatgatcct     2280

ccagcgcggg gatctcatgc tggagttctt cgcccacccc gggatctatg tcgggtgcgg     2340

agaaagaggt aatgaaatgg cacctaggta tcgatactag tatacgttat taatagtaat     2400

caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg     2460

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt     2520

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gactatttac     2580

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg     2640

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact     2700

ttcctacttg gcagtacatc tacgtattag tcatcgctat tactcatggg tcgaggtgag     2760

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt     2820

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag     2880

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca     2940

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct     3000

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgtt gccttcgccc cgtgccccgc     3060

tccgcgccgc ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga     3120

gcgggcggga cggcccttct cctccgggct gtaattagcg cttggtttaa tgacggctcg     3180

tttcttttct gtggctgcgt gaaagcctta aagggctccg ggagggccct ttgtgcgggg     3240

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggcccg     3300

cgctgcccgg cggctgtgag cgctgcgggc gcggcgcggg gctttgtgcg ctccgcgtgt     3360

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc gggggggctg cgaggggaac     3420

aaaggctgcg tgcggggtgt gtgcgtgggg gggtgagcag ggggtgtggg cgcggcggtc     3480

gggctgtaac ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     3540

tgcggggctc cgtgcggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     3600

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     3660

cggcggcccc ggagcgccgg cggctgtcga ggcgcggcga gccgcagcca ttgcctttta     3720

tggtaatcgt gcgagagggc gcagggactt cctttgtccc aaatctggcg gagccgaaat     3780

ctgggaggcg ccgccgcacc ccctctagcg ggcgcgggcg aagcggtgcg gcgccggcag     3840

gaaggaaatg ggcggggagg gccttcgtgc gtcgccgcgc cgccgtcccc ttctccatct     3900

ccagcctcgg ggctgccgca gggggacggc tgccttcggg ggggacgggg cagggcgggg     3960

ttcggcttct ggcgtgtgac cggcggctgc tagagcctct gctaaccatg ttcatgcctt     4020

cttctttttc ctacagctcc tgggcaacgt gctggttgtt gtgctgtctc atcattttgg     4080

caaagaattg cggccgtctc aggccaccga agacttgatc acccgggatc atgggaaaca     4140

ccaccagcga ccgggtgtcc ggggagcgcc acggcgccaa ggctgcacgc tccgagggcg     4200

caggcggcca tgccccgggg aaggagcaca agatcatggt ggggagtacg gacgacccca     4260

gcgtgttcag cctccctgac tccaagctcc ctggggacaa agagtttgta tcatggcagc     4320

aggatttgga ggactccgta aagcccacac agcaggcccg gcccactgtt atccgctggt     4380

ctgaaggagg caaggaggtc ttcatctctg ggtccttcaa caattggagc gccaagattc     4440

cactgattaa gagccataat gactttgttg ccatcctgga cctccctgag ggagagcacc     4500

aatacaagtt ctttgtggat ggacagtggg ttcatgatcc atcagagcct gtggttacca     4560

gtcagcttgg cacaattaac aatttgatcc atgtcaagaa atctgatttt gaggtgttcg     4620

atgctttaaa gttagattct atggaaagtt ctgagacatc ttgtagagac ctttccagct     4680

cacccccagg gccttatggt caagaaatgt atgcgtttcg atctgaggaa agattcaaat     4740

ccccacccat ccttcctcct catctacttc aagttattct taacaaagac actaatattt     4800

cttgtgaccc agccttactc cctgagccca accatgttat gctgaaccat ctctatgcat     4860

tgtccattaa ggacagtgtg atggtcctta gcgcaaccca tcgctacaag aagaagtatg     4920

ttactactct gctatacatg ggcggcgtgc agctcgccga ccactaccag cagaacaccc     4980

ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagctac cagtccaagc     5040

tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg     5100

ccgggatcac tctcggcatg gacgagctgt acaagggtgg cagcggtggc atggtgagca     5160

agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac ggcgacgtaa     5220

acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac ggcaagctga     5280

ccctgaagct gatctgcacc accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca     5340

ccctgggcta cggcctgcag tgcttcgccc gctaccccga ccacatgaag cagcacgact     5400

tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc ttcaaggacg     5460

acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg gtgaaccgca     5520

tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac aagctggagt     5580

acaactacaa cagccacaac gtctatatca ccgccgacaa gcagaagaac ggcatcaagg     5640

ccaacttcaa gatccgccac aacatcgagt aatga                                5675


<210>  89
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human beta2-KPI-cpVenus_deletion

<400>  89

Met Gly Asn Thr Thr Ser Asp Arg Val Ser Gly Glu Arg His Gly Ala 
1               5                   10                  15      


Lys Ala Ala Arg Ser Glu Gly Ala Gly Gly His Ala Pro Gly Lys Glu 
            20                  25                  30          


His Lys Ile Met Val Gly Ser Thr Asp Asp Pro Ser Val Phe Ser Leu 
        35                  40                  45              


Pro Asp Ser Lys Leu Pro Gly Asp Lys Glu Phe Val Ser Trp Gln Gln 
    50                  55                  60                  


Asp Leu Glu Asp Ser Val Lys Pro Thr Gln Gln Ala Arg Pro Thr Val 
65                  70                  75                  80  


Ile Arg Trp Ser Glu Gly Gly Lys Glu Val Phe Ile Ser Gly Ser Phe 
                85                  90                  95      


Asn Asn Trp Ser Ala Lys Ile Pro Leu Ile Lys Ser His Asn Asp Phe 
            100                 105                 110         


Val Ala Ile Leu Asp Leu Pro Glu Gly Glu His Gln Tyr Lys Phe Phe 
        115                 120                 125             


Val Asp Gly Gln Trp Val His Asp Pro Ser Glu Pro Val Val Thr Ser 
    130                 135                 140                 


Gln Leu Gly Thr Ile Asn Asn Leu Ile His Val Lys Lys Ser Asp Phe 
145                 150                 155                 160 


Glu Val Phe Asp Ala Leu Lys Leu Asp Ser Met Glu Ser Ser Glu Thr 
                165                 170                 175     


Ser Cys Arg Asp Leu Ser Ser Ser Pro Pro Gly Pro Tyr Gly Gln Glu 
            180                 185                 190         


Met Tyr Ala Phe Arg Ser Glu Glu Arg Phe Lys Ser Pro Pro Ile Leu 
        195                 200                 205             


Pro Pro His Leu Leu Gln Val Ile Leu Asn Lys Asp Thr Asn Ile Ser 
    210                 215                 220                 


Cys Asp Pro Ala Leu Leu Pro Glu Pro Asn His Val Met Leu Asn His 
225                 230                 235                 240 


Leu Tyr Ala Leu Ser Ile Lys Asp Ser Val Met Val Leu Ser Ala Thr 
                245                 250                 255     


His Arg Tyr Lys Lys Lys Tyr Val Thr Thr Leu Leu Tyr Met Gly Gly 
            260                 265                 270         


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
        275                 280                 285             


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Lys Leu 
    290                 295                 300                 


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
305                 310                 315                 320 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
                325                 330                 335     


Gly Ser Gly Gly Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
            340                 345                 350         


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
        355                 360                 365             


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
    370                 375                 380                 


Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
385                 390                 395                 400 


Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro 
                405                 410                 415     


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
            420                 425                 430         


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
        435                 440                 445             


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
    450                 455                 460                 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
465                 470                 475                 480 


Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp 
                485                 490                 495     


Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile 
            500                 505                 510         


Glu 
    


<210>  90
<211>  5081
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1, pMDS plasmid

<400>  90
tcgagccatg gtgctagcag ctgatgcata gcatgcggta cctaattcac tcctcaggtg       60

caggctgcct atcagaaggt ggtggctggt gtggctaatg ccctggctca caaataccac      120

tgagatcttt ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg      180

acttctggct aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt      240

ctctcactcg gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg      300

gtttagagtt tggcaacata tgccatatgc tggctgccat gaacaaaggt ggctataaag      360

aggtcatcag tatatgaaac agccccctgc tgtccattcc ttattccata gaaaagcctt      420

gacttgaggt tagatttttt ttatattttg ttttgtgtta tttttttctt taacatccct      480

aaaattttcc ttacatgttt tactagccag atttttcctc ctctcctgac tactcccagt      540

catagctgtc cctcttctct tatgaagatc cctcgacgtt taaacccatg tgcctggcag      600

ataacttcgt ataatgtatg ctatacgaag ttatggtacg tactaagctc tcatgtttca      660

cgtactaagc tctcatgttt aacgtactaa gctctcatgt ttaacgaact aaaccctcat      720

ggctaacgta ctaagctctc atggctaacg tactaagctc tcatgtttca cgtactaagc      780

tctcatgttt gaacaataaa attaatataa atcagcaact taaatagcct ctaaggtttt      840

aagttttata agaaaaaaaa gaatatataa ggcttttaaa gcttttaagg tttaacggtt      900

gtggacaaca agccagggat gtaacgcact gagaagccct tagagcctct caaagcaatt      960

ttgagtgaca caggaacact taacggctga cataattcag cttcacgctg ccgcaagcac     1020

tcagggcgca agggctgcta aaggaagcgg aacacgtaga aagccagtcc gcagaaacgg     1080

tgctgacccc ggatgaatgt cagctgggag gcagaataaa tgatcatatc gtcaattatt     1140

acctccacgg ggagagcctg agcaaactgg cctcaggcat ttgagaagca cacggtcaca     1200

ctgcttccgg tagtcaataa accggtaagt agcgtatgcg ctcacgcaac tggtccagaa     1260

ccttgaccga acgcagcggt ggtaacggcg cagtggcggt tttcatggct tgttatgact     1320

gtttttttgg ggtacagtct atgcctcggg catccaagca gcaagcgcgt tacgccgtgg     1380

gtcgatgttt gatgttatgg agcagcaacg atgttacgca gcagggcagt cgccctaaaa     1440

caaagttaaa catcatgagg gaagcggtga tcgccgaagt atcgactcaa ctatcagagg     1500

tagttggcgt catcgagcgc catctcgaac cgacgttgct ggccgtacat ttgtacggct     1560

ccgcagtgga tggcggcctg aagccacaca gtgatattga tttgctggtt acggtgaccg     1620

taaggcttga tgaaacaacg cggcgagctt tgatcaacga ccttttggaa acttcggctt     1680

cccctggaga gagcgagatt ctccgcgctg tagaagtcac cattgttgtg cacgacgaca     1740

tcattccgtg gcgttatcca gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg     1800

acattcttgc aggtatcttc gagccagcca cgatcgacat tgatctggct atcttgctga     1860

caaaagcaag agaacatagc gttgccttgg taggtccagc ggcggaggaa ctctttgatc     1920

cggttcctga acaggatcta tttgaggcgc taaatgaaac cttaacgcta tggaactcgc     1980

cgcccgactg ggctggcgat gagcgaaatg tagtgcttac gttgtcccgc atttggtaca     2040

gcgcagtaac cggcaaaatc gcgccgaagg atgtcgctgc cgactgggca atggagcgcc     2100

tgccggccca gtatcagccc gtcatacttg aagctagaca ggcttatctt ggacaagaag     2160

aagatcgctt ggcctcgcgc gcagatcagt tggaagaatt tgtccactac gtgaaaggcg     2220

agatcaccaa ggtagtcggc aaataatgtc taacaattcg ttcaagccga cggatctatg     2280

tcgggtgcgg agaaagaggt aatgaaatgg cacctaggta tcgatactac gatactagta     2340

tacgttatta atagtaatca attacggggt cattagttca tagcccatat atggagttcc     2400

gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat     2460

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc     2520

aatgggtgga ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc     2580

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt     2640

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta     2700

ctcatgggtc gaggtgagcc ccacgttctg cttcactctc cccatctccc ccccctcccc     2760

acccccaatt ttgtatttat ttatttttta attattttgt gcagcgatgg gggcgggggg     2820

ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga     2880

gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc     2940

ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc     3000

cttcgccccg tgccccgctc cgcgccgcct cgcgccgccc gccccggctc tgactgaccg     3060

cgttactccc acaggtgagc gggcgggacg gcccttctcc tccgggctgt aattagcgct     3120

tggtttaatg acggctcgtt tcttttctgt ggctgcgtga aagccttaaa gggctccggg     3180

agggcccttt gtgcgggggg gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg     3240

agcgccgcgt gcggcccgcg ctgcccggcg gctgtgagcg ctgcgggcgc ggcgcggggc     3300

tttgtgcgct ccgcgtgtgc gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg     3360

gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg     3420

ggtgtgggcg cggcggtcgg gctgtaaccc ccccctgcac ccccctcccc gagttgctga     3480

gcacggcccg gcttcgggtg cggggctccg tgcggggcgt ggcgcggggc tcgccgtgcc     3540

gggcgggggg tggcggcagg tgggggtgcc gggcggggcg gggccgcctc gggccgggga     3600

gggctcgggg gaggggcgcg gcggccccgg agcgccggcg gctgtcgagg cgcggcgagc     3660

cgcagccatt gccttttatg gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa     3720

atctggcgga gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcgggcgaa     3780

gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg     3840

ccgtcccctt ctccatctcc agcctcgggg ctgccgcagg gggacggctg ccttcggggg     3900

ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctgcta gagcctctgc     3960

taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc tggttgttgt     4020

gctgtctcat cattttggca aagaattgcg gccgtctcag gccaccgaag acttgatcac     4080

ccgggatcat ggagtcggtt gctgcagaga gcgctccagc tccggagaat gaacactctc     4140

aagagacccc ggaatcgaac agtagtgtgt acaccacctt catgaagtct catcgctgct     4200

atgacctgat ccccacaagc tccaagctgg tggtatttga tacttcgctg caggtaaaga     4260

aagccttctt tgccctggtg actaacggtg ttcgtgctgc ccctttgtgg gatagtaaga     4320

agcagagctt tgtgggcatg ctgaccatca ctgacttcat caatattctg caccgatact     4380

acaagtcagc cctggtgcag atctatgaac tggaggagca caagatagag acttggagag     4440

aggtctacct gcaagactcc tttaagccac ttgtctgcat ttctccaaat gccagcttgt     4500

tcgatgctgt ctcttcatta attcgaaata agatccacag gcttccagtt attgacccgg     4560

agtcaggcaa caccttgtac attcttactc acaagcggat cctcaagttc ctcaagttgt     4620

ttatcactga gttccccaag ccggaattca tgtctaagtc tctggaagag ctacagattg     4680

gcacctacgc caatattgcc atggtccgta ccactacacc tgtctatgtg gctctgggca     4740

tctttgtaca gcaccgagtc tccgccttgc ctgtggtgga tgagaaaggg cgtgtggtgg     4800

acatctactc caagtttgat gtgattaatt tggcagcaga aaagacatac aacaacctag     4860

atgtgtctgt gacaaaagcc ctacagcacc ggtcacacta cttcgagggt gttctcaagt     4920

gctacctaca tgagactcta gaagcaatca tcaatagact ggtggaagca gaggttcacc     4980

gtctggtggt ggtggatgaa catgacgtgg tcaagggcat tgtatcgctg tctgacatct     5040

tacaggctct ggtgctcaca ggtggagaga agaagccctg a                         5081


<210>  91
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  91

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro 
                325                 330 


<210>  92
<211>  5792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-LTGGEKKP-cpVenus_deletion, pMDS plasmid

<400>  92
tcgagccatg gtgctagcag ctgatgcata gcatgcggta cctaattcac tcctcaggtg       60

caggctgcct atcagaaggt ggtggctggt gtggctaatg ccctggctca caaataccac      120

tgagatcttt ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg      180

acttctggct aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt      240

ctctcactcg gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg      300

gtttagagtt tggcaacata tgccatatgc tggctgccat gaacaaaggt ggctataaag      360

aggtcatcag tatatgaaac agccccctgc tgtccattcc ttattccata gaaaagcctt      420

gacttgaggt tagatttttt ttatattttg ttttgtgtta tttttttctt taacatccct      480

aaaattttcc ttacatgttt tactagccag atttttcctc ctctcctgac tactcccagt      540

catagctgtc cctcttctct tatgaagatc cctcgacgtt taaacccatg tgcctggcag      600

ataacttcgt ataatgtatg ctatacgaag ttatggtacg tactaagctc tcatgtttca      660

cgtactaagc tctcatgttt aacgtactaa gctctcatgt ttaacgaact aaaccctcat      720

ggctaacgta ctaagctctc atggctaacg tactaagctc tcatgtttca cgtactaagc      780

tctcatgttt gaacaataaa attaatataa atcagcaact taaatagcct ctaaggtttt      840

aagttttata agaaaaaaaa gaatatataa ggcttttaaa gcttttaagg tttaacggtt      900

gtggacaaca agccagggat gtaacgcact gagaagccct tagagcctct caaagcaatt      960

ttgagtgaca caggaacact taacggctga cataattcag cttcacgctg ccgcaagcac     1020

tcagggcgca agggctgcta aaggaagcgg aacacgtaga aagccagtcc gcagaaacgg     1080

tgctgacccc ggatgaatgt cagctgggag gcagaataaa tgatcatatc gtcaattatt     1140

acctccacgg ggagagcctg agcaaactgg cctcaggcat ttgagaagca cacggtcaca     1200

ctgcttccgg tagtcaataa accggtaagt agcgtatgcg ctcacgcaac tggtccagaa     1260

ccttgaccga acgcagcggt ggtaacggcg cagtggcggt tttcatggct tgttatgact     1320

gtttttttgg ggtacagtct atgcctcggg catccaagca gcaagcgcgt tacgccgtgg     1380

gtcgatgttt gatgttatgg agcagcaacg atgttacgca gcagggcagt cgccctaaaa     1440

caaagttaaa catcatgagg gaagcggtga tcgccgaagt atcgactcaa ctatcagagg     1500

tagttggcgt catcgagcgc catctcgaac cgacgttgct ggccgtacat ttgtacggct     1560

ccgcagtgga tggcggcctg aagccacaca gtgatattga tttgctggtt acggtgaccg     1620

taaggcttga tgaaacaacg cggcgagctt tgatcaacga ccttttggaa acttcggctt     1680

cccctggaga gagcgagatt ctccgcgctg tagaagtcac cattgttgtg cacgacgaca     1740

tcattccgtg gcgttatcca gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg     1800

acattcttgc aggtatcttc gagccagcca cgatcgacat tgatctggct atcttgctga     1860

caaaagcaag agaacatagc gttgccttgg taggtccagc ggcggaggaa ctctttgatc     1920

cggttcctga acaggatcta tttgaggcgc taaatgaaac cttaacgcta tggaactcgc     1980

cgcccgactg ggctggcgat gagcgaaatg tagtgcttac gttgtcccgc atttggtaca     2040

gcgcagtaac cggcaaaatc gcgccgaagg atgtcgctgc cgactgggca atggagcgcc     2100

tgccggccca gtatcagccc gtcatacttg aagctagaca ggcttatctt ggacaagaag     2160

aagatcgctt ggcctcgcgc gcagatcagt tggaagaatt tgtccactac gtgaaaggcg     2220

agatcaccaa ggtagtcggc aaataatgtc taacaattcg ttcaagccga cggatctatg     2280

tcgggtgcgg agaaagaggt aatgaaatgg cacctaggta tcgatactac gatactagta     2340

tacgttatta atagtaatca attacggggt cattagttca tagcccatat atggagttcc     2400

gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat     2460

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc     2520

aatgggtgga ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc     2580

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt     2640

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta     2700

ctcatgggtc gaggtgagcc ccacgttctg cttcactctc cccatctccc ccccctcccc     2760

acccccaatt ttgtatttat ttatttttta attattttgt gcagcgatgg gggcgggggg     2820

ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga     2880

gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc     2940

ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc     3000

cttcgccccg tgccccgctc cgcgccgcct cgcgccgccc gccccggctc tgactgaccg     3060

cgttactccc acaggtgagc gggcgggacg gcccttctcc tccgggctgt aattagcgct     3120

tggtttaatg acggctcgtt tcttttctgt ggctgcgtga aagccttaaa gggctccggg     3180

agggcccttt gtgcgggggg gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg     3240

agcgccgcgt gcggcccgcg ctgcccggcg gctgtgagcg ctgcgggcgc ggcgcggggc     3300

tttgtgcgct ccgcgtgtgc gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg     3360

gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg     3420

ggtgtgggcg cggcggtcgg gctgtaaccc ccccctgcac ccccctcccc gagttgctga     3480

gcacggcccg gcttcgggtg cggggctccg tgcggggcgt ggcgcggggc tcgccgtgcc     3540

gggcgggggg tggcggcagg tgggggtgcc gggcggggcg gggccgcctc gggccgggga     3600

gggctcgggg gaggggcgcg gcggccccgg agcgccggcg gctgtcgagg cgcggcgagc     3660

cgcagccatt gccttttatg gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa     3720

atctggcgga gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcgggcgaa     3780

gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg     3840

ccgtcccctt ctccatctcc agcctcgggg ctgccgcagg gggacggctg ccttcggggg     3900

ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctgcta gagcctctgc     3960

taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc tggttgttgt     4020

gctgtctcat cattttggca aagaattgcg gccgtctcag gccaccgaag acttgatcac     4080

ccgggatcat ggagtcggtt gctgcagaga gcgctccagc tccggagaat gaacactctc     4140

aagagacccc ggaatcgaac agtagtgtgt acaccacctt catgaagtct catcgctgct     4200

atgacctgat ccccacaagc tccaagctgg tggtatttga tacttcgctg caggtaaaga     4260

aagccttctt tgccctggtg actaacggtg ttcgtgctgc ccctttgtgg gatagtaaga     4320

agcagagctt tgtgggcatg ctgaccatca ctgacttcat caatattctg caccgatact     4380

acaagtcagc cctggtgcag atctatgaac tggaggagca caagatagag acttggagag     4440

aggtctacct gcaagactcc tttaagccac ttgtctgcat ttctccaaat gccagcttgt     4500

tcgatgctgt ctcttcatta attcgaaata agatccacag gcttccagtt attgacccgg     4560

agtcaggcaa caccttgtac attcttactc acaagcggat cctcaagttc ctcaagttgt     4620

ttatcactga gttccccaag ccggaattca tgtctaagtc tctggaagag ctacagattg     4680

gcacctacgc caatattgcc atggtccgta ccactacacc tgtctatgtg gctctgggca     4740

tctttgtaca gcaccgagtc tccgccttgc ctgtggtgga tgagaaaggg cgtgtggtgg     4800

acatctactc caagtttgat gtgattaatt tggcagcaga aaagacatac aacaacctag     4860

atgtgtctgt gacaaaagcc ctacagcacc ggtcacacta cttcgagggt gttctcaagt     4920

gctacctaca tgagactcta gaagcaatca tcaatagact ggtggaagca gaggttcacc     4980

gtctggtggt ggtggatgaa catgacgtgg tcaagggcat tgtatcgctg tctgacatct     5040

tacaggctct ggtgatgggc ggcgtgcagc tcgccgacca ctaccagcag aacaccccca     5100

tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagctaccag tccaagctga     5160

gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg accgccgccg     5220

ggatcactct cggcatggac gagctgtaca agggtggcag cggtggcatg gtgagcaagg     5280

gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg     5340

gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc     5400

tgaagctgat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc     5460

tgggctacgg cctgcagtgc ttcgcccgct accccgacca catgaagcag cacgacttct     5520

tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg     5580

gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg     5640

agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag ctggagtaca     5700

actacaacag ccacaacgtc tatatcaccg ccgacaagca gaagaacggc atcaaggcca     5760

acttcaagat ccgccacaac atcgagtaat ga                                   5792


<210>  93
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat gamma1-LTGGEKKP-cpVenus_deletion

<400>  93

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Met Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
                325                 330                 335     


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
            340                 345                 350         


Tyr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
        355                 360                 365             


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp 
    370                 375                 380                 


Glu Leu Tyr Lys Gly Gly Ser Gly Gly Met Val Ser Lys Gly Glu Glu 
385                 390                 395                 400 


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
                405                 410                 415     


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
            420                 425                 430         


Tyr Gly Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro 
        435                 440                 445             


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys 
    450                 455                 460                 


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
465                 470                 475                 480 


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
                485                 490                 495     


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
            500                 505                 510         


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
        515                 520                 525             


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
    530                 535                 540                 


Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys 
545                 550                 555                 560 


Ile Arg His Asn Ile Glu 
                565     


<210>  94
<211>  5125
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rat gamma1 subunit, V275G and L276G mutation, pMDS plasmid

<400>  94
cgatactacg atactagtat acgttattaa tagtaatcaa ttacggggtc attagttcat       60

agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg      120

cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata      180

gggactttcc attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta      240

catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc      300

gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca gtacatctac      360

gtattagtca tcgctattac tcatgggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggcgc gcgccaggcg gggcggggcg gggcgagggg      540

cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc gctccgaaag      600

tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg      660

gcgggagtcg ctgcgttgcc ttcgccccgt gccccgctcc gcgccgcctc gcgccgcccg      720

ccccggctct gactgaccgc gttactccca caggtgagcg ggcgggacgg cccttctcct      780

ccgggctgta attagcgctt ggtttaatga cggctcgttt cttttctgtg gctgcgtgaa      840

agccttaaag ggctccggga gggccctttg tgcggggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggcccgcgc tgcccggcgg ctgtgagcgc      960

tgcgggcgcg gcgcggggct ttgtgcgctc cgcgtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg     1080

cgtggggggg tgagcagggg gtgtgggcgc ggcggtcggg ctgtaacccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt gcggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggccccgga gcgccggcgg     1320

ctgtcgaggc gcggcgagcc gcagccattg ccttttatgg taatcgtgcg agagggcgca     1380

gggacttcct ttgtcccaaa tctggcggag ccgaaatctg ggaggcgccg ccgcaccccc     1440

tctagcgggc gcgggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1500

ttcgtgcgtc gccgcgccgc cgtccccttc tccatctcca gcctcggggc tgccgcaggg     1560

ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc gtgtgaccgg     1620

cggctgctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1680

gcaacgtgct ggttgttgtg ctgtctcatc attttggcaa agaattgcgg ccgtctcagg     1740

ccaccgaaga cttgatcacc cgggatctcg agccatggtg ctagaaataa ttttgtttaa     1800

ctttaagaag gagatataca tatggagtcg gttgctgcag agagcgctcc agctccggag     1860

aatgaacact ctcaagagac cccggaatcg aacagtagtg tgtacaccac cttcatgaag     1920

tctcatcgct gctatgacct gatccccaca agctccaagc tggtggtatt tgatacttcg     1980

ctgcaggtaa agaaagcctt ctttgccctg gtgactaacg gtgttcgtgc tgcccctttg     2040

tgggatagta agaagcagag ctttgtgggc atgctgacca tcactgactt catcaatatt     2100

ctgcaccgat actacaagtc agccctggtg cagatctatg aactggagga gcacaagata     2160

gagacttgga gagaggtcta cctgcaagac tcctttaagc cacttgtctg catttctcca     2220

aatgccagct tgttcgatgc tgtctcttca ttaattcgaa ataagatcca caggcttcca     2280

gttattgacc cggagtcagg caacaccttg tacattctta ctcacaagcg gatcctcaag     2340

ttcctcaagt tgtttatcac tgagttcccc aagccggaat tcatgtctaa gtctctggaa     2400

gagctacaga ttggcaccta cgccaatatt gccatggtcc gtaccactac acctgtctat     2460

gtggctctgg gcatctttgt acagcaccga gtctccgcct tgcctgtggt ggatgagaaa     2520

gggcgtgtgg tggacatcta ctccaagttt gatgtgatta atttggcagc agaaaagaca     2580

tacaacaacc tagatgtgtc tgtgacaaaa gccctacagc accggtcaca ctacttcgag     2640

ggtggaggta agtgctacct acatgagact ctcgaggcaa tcatcaatag actggtggaa     2700

gcagaggttc accgtctggt ggtggtggat gaacatgacg tggtcaaggg cattgtatcg     2760

ctgtctgaca tcttacaggc tctggtgctc acaggtggag agaagaagcc ctgataacta     2820

gcagctgatg catagcatgc ggtacctaat tcactcctca ggtgcaggct gcctatcaga     2880

aggtggtggc tggtgtggct aatgccctgg ctcacaaata ccactgagat ctttttccct     2940

ctgccaaaaa ttatggggac atcatgaagc cccttgagca tctgacttct ggctaataaa     3000

ggaaatttat tttcattgca atagtgtgtt ggaatttttt gtgtctctca ctcggaagga     3060

catatgggag ggcaaatcat ttaaaacatc agaatgagta tttggtttag agtttggcaa     3120

catatgccat atgctggctg ccatgaacaa aggtggctat aaagaggtca tcagtatatg     3180

aaacagcccc ctgctgtcca ttccttattc catagaaaag ccttgacttg aggttagatt     3240

ttttttatat tttgttttgt gttatttttt tctttaacat ccctaaaatt ttccttacat     3300

gttttactag ccagattttt cctcctctcc tgactactcc cagtcatagc tgtccctctt     3360

ctcttatgaa gatccctcga cgtttaaacc catgtgcctg gcagataact tcgtataatg     3420

tatgctatac gaagttatgg tacgtactaa gctctcatgt ttcacgtact aagctctcat     3480

gtttaacgta ctaagctctc atgtttaacg aactaaaccc tcatggctaa cgtactaagc     3540

tctcatggct aacgtactaa gctctcatgt ttcacgtact aagctctcat gtttgaacaa     3600

taaaattaat ataaatcagc aacttaaata gcctctaagg ttttaagttt tataagaaaa     3660

aaaagaatat ataaggcttt taaagctttt aaggtttaac ggttgtggac aacaagccag     3720

ggatgtaacg cactgagaag cccttagagc ctctcaaagc aattttgagt gacacaggaa     3780

cacttaacgg ctgacataat tcagcttcac gctgccgcaa gcactcaggg cgcaagggct     3840

gctaaaggaa gcggaacacg tagaaagcca gtccgcagaa acggtgctga ccccggatga     3900

atgtcagctg ggaggcagaa taaatgatca tatcgtcaat tattacctcc acggggagag     3960

cctgagcaaa ctggcctcag gcatttgaga agcacacggt cacactgctt ccggtagtca     4020

ataaaccggt aagtagcgta tgcgctcacg caactggtcc agaaccttga ccgaacgcag     4080

cggtggtaac ggcgcagtgg cggttttcat ggcttgttat gactgttttt ttggggtaca     4140

gtctatgcct cgggcatcca agcagcaagc gcgttacgcc gtgggtcgat gtttgatgtt     4200

atggagcagc aacgatgtta cgcagcaggg cagtcgccct aaaacaaagt taaacatcat     4260

gagggaagcg gtgatcgccg aagtatcgac tcaactatca gaggtagttg gcgtcatcga     4320

gcgccatctc gaaccgacgt tgctggccgt acatttgtac ggctccgcag tggatggcgg     4380

cctgaagcca cacagtgata ttgatttgct ggttacggtg accgtaaggc ttgatgaaac     4440

aacgcggcga gctttgatca acgacctttt ggaaacttcg gcttcccctg gagagagcga     4500

gattctccgc gctgtagaag tcaccattgt tgtgcacgac gacatcattc cgtggcgtta     4560

tccagctaag cgcgaactgc aatttggaga atggcagcgc aatgacattc ttgcaggtat     4620

cttcgagcca gccacgatcg acattgatct ggctatcttg ctgacaaaag caagagaaca     4680

tagcgttgcc ttggtaggtc cagcggcgga ggaactcttt gatccggttc ctgaacagga     4740

tctatttgag gcgctaaatg aaaccttaac gctatggaac tcgccgcccg actgggctgg     4800

cgatgagcga aatgtagtgc ttacgttgtc ccgcatttgg tacagcgcag taaccggcaa     4860

aatcgcgccg aaggatgtcg ctgccgactg ggcaatggag cgcctgccgg cccagtatca     4920

gcccgtcata cttgaagcta gacaggctta tcttggacaa gaagaagatc gcttggcctc     4980

gcgcgcagat cagttggaag aatttgtcca ctacgtgaaa ggcgagatca ccaaggtagt     5040

cggcaaataa tgtctaacaa ttcgttcaag ccgacggatc tatgtcgggt gcggagaaag     5100

aggtaatgaa atggcaccta ggtat                                           5125


<210>  95
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rat gamma 1 subunit, V275G and L276G mutation

<400>  95

Met Glu Ser Val Ala Ala Glu Ser Ala Pro Ala Pro Glu Asn Glu His 
1               5                   10                  15      


Ser Gln Glu Thr Pro Glu Ser Asn Ser Ser Val Tyr Thr Thr Phe Met 
            20                  25                  30          


Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val 
        35                  40                  45              


Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val 
    50                  55                  60                  


Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser 
65                  70                  75                  80  


Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg 
                85                  90                  95      


Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys 
            100                 105                 110         


Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu 
        115                 120                 125             


Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu 
    130                 135                 140                 


Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly 
145                 150                 155                 160 


Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys 
                165                 170                 175     


Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu 
            180                 185                 190         


Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr 
        195                 200                 205             


Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val 
    210                 215                 220                 


Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr 
225                 230                 235                 240 


Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn 
                245                 250                 255     


Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe 
            260                 265                 270         


Glu Gly Gly Gly Lys Cys Tyr Leu His Glu Thr Leu Glu Ala Ile Ile 
        275                 280                 285             


Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu 
    290                 295                 300                 


His Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala 
305                 310                 315                 320 


Leu Val Leu Thr Gly Gly Glu Lys Lys Pro 
                325                 330 


<210>  96
<211>  3566
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human beta1 subunit-YFP, KPI deletion, pDC plasmid

<400>  96
attcatccgc ttattatcac ttattcaggc gtagcaacca ggcgtttaag ggcaccaata       60

actgccttaa aaaaattacg ccccgccctg ccactcatcg cagtactgtt gtaattcatt      120

aagcattctg ccgacatgga agccatcaca aacggcatga tgaacctgaa tcgccagcgg      180

catcagcacc ttgtcgcctt gcgtataata tttgcccatg gtgaaaacgg gggcgaagaa      240

gttgtccata ttggccacgt ttaaatcaaa actggtgaaa ctcacccagg gattggctga      300

gacgaaaaac atattctcaa taaacccttt agggaaatag gccaggtttt caccgtaaca      360

cgccacatct tgcgaatata tgtgtagaaa ctgccggaaa tcgtcgtggt attcactcca      420

gagcgatgaa aacgtttcag tttgctcatg gaaaacggtg taacaagggt gaacactatc      480

ccatatcacc agctcaccgt ctttcattgc catacggaat tccggatgag cattcatcag      540

gcgggcaaga atgtgaataa aggccggata aaacttgtgc ttatttttct ttacggtctt      600

taaaaaggcc gtaatatcca gctgaacggt ctggttatag gtacattgag caactgactg      660

aaatgcctca aaatgttctt tacgatgcca ttgggatata tcaacggtgg tatatccagt      720

gatttttttc tccattttag cttccttagc tcctgaaaat ctcgataact caaaaaatac      780

gcccggtagt gatcttattt cattatggtg aaagttggac cctcttacgt gccgatcaac      840

gtctcatttt cgccaaaagt tggcccagat caacgtctca ttttcgccaa aagttggccc      900

agccatgtgc ctggcaccta ggtatcgata atacgactca ctatagggga attgtgagcg      960

gataacaatt cccctctaga aataattttg tttaacttta agaaggagat atacaatggg     1020

caatacgagc agcgagcgcg ccgcgctgga gcggcaggct ggccataaga cgccgcggag     1080

ggacagctcg gggggcacca aggatgggga caggcccaag atcctgatgg acagccccga     1140

agacgccgac atcttccaca ccgaggaaat gaaggctcca gagaaggagg agttcctggc     1200

gtggcagcac gacctcgagg tgaatgagaa agcccccgcc caggctcggc ccaccgtatt     1260

tcgatggaca gggggtggaa aggaggtcta cttgtctgga tccttcaaca actggagcaa     1320

attgcccctc actagaagcc aaaacaactt cgtagccatc ctggacctgc cggaaggaga     1380

gcatcagtac aagttctttg tggatggcca gtggacccac gatccttccg agccaatagt     1440

aaccagccag cttggcacag ttaacaacat cattcaagtg aagaaaactg actttgaagt     1500

atttgatgct ttaatggtgg attcccaaaa gtgctccgat gtatctgagc tgtccagttc     1560

ccccccagga ccctaccacc aggagcctta catctctaaa ccagaggagc ggttcaaggc     1620

cccgcccatc ctcccgcctc acctgctgca ggtcatcttg aacaaggaca cgggcatctc     1680

ttgtgatcca gcgctgcttc cggagcccaa ccacgtcatg ctgaaccacc tctatgcact     1740

ctctatcaag gatggagtga tggtgctcag tgcgacccat cggtacaaga aaaagtacgt     1800

caccaccctc ctctacatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat     1860

cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga     1920

gggcgatgcc acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc     1980

cgtgccctgg cccaccctcg tgaccacctt cggctacggc ctgcagtgct tcgcccgcta     2040

ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca     2100

ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt     2160

cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg     2220

caacatcctg gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc     2280

cgacaagcag aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg     2340

cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct     2400

gctgcccgac aaccactacc tgagctacca gtccgccctg agcaaagacc ccaacgagaa     2460

gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga     2520

cgagctgtac aagtgataat atgaggcctc ggatcctgta aaacgacggc cagtgaattc     2580

cccgggaagc ttcgccaggg ttttcccagt cgagctcgat atcggtacca gcggataaca     2640

atttcacatc cggatcgcga acgcgtctcg agagatccgg ctgctaacaa agcccgaaag     2700

gaagctgagt tggctgctgc caccgctgag caataactag cataacccct tggggcctct     2760

aaacgggtct tgaggggttt tttggtttaa acccatgtgc ctggcagata acttcgtata     2820

atgtatgcta tacgaagtta tggtaccgcg gccgcgtaga ggatctgttg atcagcagtt     2880

caacctgttg atagtacgta ctaagctctc atgtttcacg tactaagctc tcatgtttaa     2940

cgtactaagc tctcatgttt aacgaactaa accctcatgg ctaacgtact aagctctcat     3000

ggctaacgta ctaagctctc atgtttcacg tactaagctc tcatgtttga acaataaaat     3060

taatataaat cagcaactta aatagcctct aaggttttaa gttttataag aaaaaaaaga     3120

atatataagg cttttaaagc ttttaaggtt taacggttgt ggacaacaag ccagggatgt     3180

aacgcactga gaagccctta gagcctctca aagcaatttt gagtgacaca ggaacactta     3240

acggctgaca gaattagctt cacgctgccg caagcactca gggcgcaagg gctgctaaag     3300

gaagcggaac acgtagaaag ccagtccgca gaaacggtgc tgaccccgga tgaatgtcag     3360

ctgggaggca gaataaatga tcatatcgtc aattattacc tccacgggga gagcctgagc     3420

aaactggcct caggcatttg agaagcacac ggtcacactg cttccggtag tcaataaacc     3480

ggtaaaccag caatagacat aagcggctat ttaacgaccc tgccctgaac cgacgaccgg     3540

gtcgaatttg ctttcgaatt tctgcc                                          3566


<210>  97
<211>  506
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human beta1-YFP, KPI deletion

<400>  97

Met Gly Asn Thr Ser Ser Glu Arg Ala Ala Leu Glu Arg Gln Ala Gly 
1               5                   10                  15      


His Lys Thr Pro Arg Arg Asp Ser Ser Gly Gly Thr Lys Asp Gly Asp 
            20                  25                  30          


Arg Pro Lys Ile Leu Met Asp Ser Pro Glu Asp Ala Asp Ile Phe His 
        35                  40                  45              


Thr Glu Glu Met Lys Ala Pro Glu Lys Glu Glu Phe Leu Ala Trp Gln 
    50                  55                  60                  


His Asp Leu Glu Val Asn Glu Lys Ala Pro Ala Gln Ala Arg Pro Thr 
65                  70                  75                  80  


Val Phe Arg Trp Thr Gly Gly Gly Lys Glu Val Tyr Leu Ser Gly Ser 
                85                  90                  95      


Phe Asn Asn Trp Ser Lys Leu Pro Leu Thr Arg Ser Gln Asn Asn Phe 
            100                 105                 110         


Val Ala Ile Leu Asp Leu Pro Glu Gly Glu His Gln Tyr Lys Phe Phe 
        115                 120                 125             


Val Asp Gly Gln Trp Thr His Asp Pro Ser Glu Pro Ile Val Thr Ser 
    130                 135                 140                 


Gln Leu Gly Thr Val Asn Asn Ile Ile Gln Val Lys Lys Thr Asp Phe 
145                 150                 155                 160 


Glu Val Phe Asp Ala Leu Met Val Asp Ser Gln Lys Cys Ser Asp Val 
                165                 170                 175     


Ser Glu Leu Ser Ser Ser Pro Pro Gly Pro Tyr His Gln Glu Pro Tyr 
            180                 185                 190         


Ile Ser Lys Pro Glu Glu Arg Phe Lys Ala Pro Pro Ile Leu Pro Pro 
        195                 200                 205             


His Leu Leu Gln Val Ile Leu Asn Lys Asp Thr Gly Ile Ser Cys Asp 
    210                 215                 220                 


Pro Ala Leu Leu Pro Glu Pro Asn His Val Met Leu Asn His Leu Tyr 
225                 230                 235                 240 


Ala Leu Ser Ile Lys Asp Gly Val Met Val Leu Ser Ala Thr His Arg 
                245                 250                 255     


Tyr Lys Lys Lys Tyr Val Thr Thr Leu Leu Tyr Met Val Ser Lys Gly 
            260                 265                 270         


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
        275                 280                 285             


Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
    290                 295                 300                 


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
305                 310                 315                 320 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu 
                325                 330                 335     


Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
            340                 345                 350         


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
        355                 360                 365             


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
    370                 375                 380                 


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
385                 390                 395                 400 


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His 
                405                 410                 415     


Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn 
            420                 425                 430         


Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp 
        435                 440                 445             


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
    450                 455                 460                 


Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
465                 470                 475                 480 


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
                485                 490                 495     


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            500                 505     


<210>  98
<211>  2858
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human beta1 subunit, pDC plasmid

<400>  98
ctcctgaaaa tctcgataac tcaaaaaata cgcccggtag tgatcttatt tcattatggt       60

gaaagttgga ccctcttacg tgccgatcaa cgtctcattt tcgccaaaag ttggcccaga      120

tcaacgtctc attttcgcca aaagttggcc cagccatgtg cctggcacct aggtatcgat      180

aatacgactc actatagggg aattgtgagc ggataacaat tcccctctag aaataatttt      240

gtttaacttt aagaaggaga tatacaatgg gcaatacgag cagcgagcgc gccgcgctgg      300

agcggcaggc tggccataag acgccgcgga gggacagctc ggggggcacc aaggatgggg      360

acaggcccaa gatcctgatg gacagccccg aagacgccga catcttccac accgaggaaa      420

tgaaggctcc agagaaggag gagttcctgg cgtggcagca cgacctcgag gtgaatgaga      480

aagcccccgc ccaggctcgg cccaccgtat ttcgatggac agggggtgga aaggaggtct      540

acttgtctgg atccttcaac aactggagca aattgcccct cactagaagc caaaacaact      600

tcgtagccat cctggacctg ccggaaggag agcatcagta caagttcttt gtggatggcc      660

agtggaccca cgatccttcc gagccaatag taaccagcca gcttggcaca gttaacaaca      720

tcattcaagt gaagaaaact gactttgaag tatttgatgc tttaatggtg gattcccaaa      780

agtgctccga tgtatctgag ctgtccagtt cccccccagg accctaccac caggagcctt      840

acatctctaa accagaggag cggttcaagg ccccgcccat cctcccgcct cacctgctgc      900

aggtcatctt gaacaaggac acgggcatct cttgtgatcc agcgctgctt ccggagccca      960

accacgtcat gctgaaccac ctctatgcac tctctatcaa ggatggagtg atggtgctca     1020

gtgcgaccca tcggtacaag aaaaagtacg tcaccaccct cctctacaag cccatatgat     1080

aatatgaggc ctcggatcct gtaaaacgac ggccagtgaa ttccccggga agcttcgcca     1140

gggttttccc agtcgagctc gatatcggta ccagcggata acaatttcac atccggatcg     1200

cgaacgcgtc tcgagagatc cggctgctaa caaagcccga aaggaagctg agttggctgc     1260

tgccaccgct gagcaataac tagcataacc ccttggggcc tctaaacggg tcttgagggg     1320

ttttttggtt taaacccatg tgcctggcag ataacttcgt ataatgtatg ctatacgaag     1380

ttatggtacc gcggccgcgt agaggatctg ttgatcagca gttcaacctg ttgatagtac     1440

gtactaagct ctcatgtttc acgtactaag ctctcatgtt taacgtacta agctctcatg     1500

tttaacgaac taaaccctca tggctaacgt actaagctct catggctaac gtactaagct     1560

ctcatgtttc acgtactaag ctctcatgtt tgaacaataa aattaatata aatcagcaac     1620

ttaaatagcc tctaaggttt taagttttat aagaaaaaaa agaatatata aggcttttaa     1680

agcttttaag gtttaacggt tgtggacaac aagccaggga tgtaacgcac tgagaagccc     1740

ttagagcctc tcaaagcaat tttgagtgac acaggaacac ttaacggctg acagaattag     1800

cttcacgctg ccgcaagcac tcagggcgca agggctgcta aaggaagcgg aacacgtaga     1860

aagccagtcc gcagaaacgg tgctgacccc ggatgaatgt cagctgggag gcagaataaa     1920

tgatcatatc gtcaattatt acctccacgg ggagagcctg agcaaactgg cctcaggcat     1980

ttgagaagca cacggtcaca ctgcttccgg tagtcaataa accggtaaac cagcaataga     2040

cataagcggc tatttaacga ccctgccctg aaccgacgac cgggtcgaat ttgctttcga     2100

atttctgcca ttcatccgct tattatcact tattcaggcg tagcaaccag gcgtttaagg     2160

gcaccaataa ctgccttaaa aaaattacgc cccgccctgc cactcatcgc agtactgttg     2220

taattcatta agcattctgc cgacatggaa gccatcacaa acggcatgat gaacctgaat     2280

cgccagcggc atcagcacct tgtcgccttg cgtataatat ttgcccatgg tgaaaacggg     2340

ggcgaagaag ttgtccatat tggccacgtt taaatcaaaa ctggtgaaac tcacccaggg     2400

attggctgag acgaaaaaca tattctcaat aaacccttta gggaaatagg ccaggttttc     2460

accgtaacac gccacatctt gcgaatatat gtgtagaaac tgccggaaat cgtcgtggta     2520

ttcactccag agcgatgaaa acgtttcagt ttgctcatgg aaaacggtgt aacaagggtg     2580

aacactatcc catatcacca gctcaccgtc tttcattgcc atacggaatt ccggatgagc     2640

attcatcagg cgggcaagaa tgtgaataaa ggccggataa aacttgtgct tatttttctt     2700

tacggtcttt aaaaaggccg taatatccag ctgaacggtc tggttatagg tacattgagc     2760

aactgactga aatgcctcaa aatgttcttt acgatgccat tgggatatat caacggtggt     2820

atatccagtg atttttttct ccattttagc ttccttag                             2858


<210>  99
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human beta1 subunit

<400>  99

Met Gly Asn Thr Ser Ser Glu Arg Ala Ala Leu Glu Arg Gln Ala Gly 
1               5                   10                  15      


His Lys Thr Pro Arg Arg Asp Ser Ser Gly Gly Thr Lys Asp Gly Asp 
            20                  25                  30          


Arg Pro Lys Ile Leu Met Asp Ser Pro Glu Asp Ala Asp Ile Phe His 
        35                  40                  45              


Thr Glu Glu Met Lys Ala Pro Glu Lys Glu Glu Phe Leu Ala Trp Gln 
    50                  55                  60                  


His Asp Leu Glu Val Asn Glu Lys Ala Pro Ala Gln Ala Arg Pro Thr 
65                  70                  75                  80  


Val Phe Arg Trp Thr Gly Gly Gly Lys Glu Val Tyr Leu Ser Gly Ser 
                85                  90                  95      


Phe Asn Asn Trp Ser Lys Leu Pro Leu Thr Arg Ser Gln Asn Asn Phe 
            100                 105                 110         


Val Ala Ile Leu Asp Leu Pro Glu Gly Glu His Gln Tyr Lys Phe Phe 
        115                 120                 125             


Val Asp Gly Gln Trp Thr His Asp Pro Ser Glu Pro Ile Val Thr Ser 
    130                 135                 140                 


Gln Leu Gly Thr Val Asn Asn Ile Ile Gln Val Lys Lys Thr Asp Phe 
145                 150                 155                 160 


Glu Val Phe Asp Ala Leu Met Val Asp Ser Gln Lys Cys Ser Asp Val 
                165                 170                 175     


Ser Glu Leu Ser Ser Ser Pro Pro Gly Pro Tyr His Gln Glu Pro Tyr 
            180                 185                 190         


Ile Ser Lys Pro Glu Glu Arg Phe Lys Ala Pro Pro Ile Leu Pro Pro 
        195                 200                 205             


His Leu Leu Gln Val Ile Leu Asn Lys Asp Thr Gly Ile Ser Cys Asp 
    210                 215                 220                 


Pro Ala Leu Leu Pro Glu Pro Asn His Val Met Leu Asn His Leu Tyr 
225                 230                 235                 240 


Ala Leu Ser Ile Lys Asp Gly Val Met Val Leu Ser Ala Thr His Arg 
                245                 250                 255     


Tyr Lys Lys Lys Tyr Val Thr Thr Leu Leu Tyr Lys Pro Ile 
            260                 265                 270 


