                         SEQUENCE LISTING

<110>  Cargill, Incorporated
       Brady, Keith
 
<120>  Method for Fermenting Sugars Using Genetically Engineered Yeast

<130>  N00258WO01

<150>  US 62/013996
<151>  2014-06-18

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cyb2a 5' Flank

<400>  1
aacagtatcg atgaaaggtg tacgacttta taagagggct tttctcgtag ctctttcaaa       60

tagtatctca ttgtatacta agatagtttg tatttgtgtg tgtgtgtcag tgtaagtgtt      120

agtatacttg ttttcctctt tcccctagag ttggtggtgt gttttgttgg aacgtacatt      180

agatgcataa tgcgtgacac cgccatgatg gttgtattct accaatgaga catggccgtt      240

gatcctgctg tgtgggtcat gagacatcac ctcttggggg ggattctcct ataattggca      300

ccgtgtatgc ctcaaccact aacttccacc ctataactga atatattaca taagcaaatc      360

tactttttgt ttgtgttgat cgccatcgtt gaaattcgcg caacttctgg tggctcaacg      420

ctgctgttct atcggtatcc taagagatgt ctttgccctg agtctagggt aaactatcca      480

ccttcgttgc tgtttgacta gacagctact aactttaggg tagtaaatga ataacggctc      540

gctctcatga tcacttctct acatcaccct aacaagtgta ttattttttt ttcaagtggg      600

tgttgctgtt ggtgctagcc ttagtgccct cgttaatagt tgaacaaaca ctggcatttg      660

gagtataatg aaaagggatc actacccccc gcttcctgtt ccgcttctcc cttccggaaa      720

aaccacccac cctttctttt cccccactaa tgtatgaatt tttccgttcc caggggaatg      780

gcccacttgg ttctctgtta acccacacaa ttttgacgca tcccacacac cttttttttt      840

tctaccccac actttccctt gaaaaatctc caatttgaac tggcaatttt caccccccac      900

cacttgcatt cattagtgag tcaatccatc ccgcggtcgg agattcggaa tccacctact      960

ggtaatctgt aatctatatt cccgctgacc ctt                                   993


<210>  2
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cyb2a 3' Flank

<400>  2
tagatactgc tcctcctcca atcgaattat tagctgaaac tgttccaact ttgaagagat       60

tgggtaaatt aagaccagat tttgaaattt taattgacgg tggtgtcaaa agaggtaccg      120

atattttgaa agcagtcgca atcggtggcc aagatgtcag agtttcagtt ggtatgggta      180

gacctttctt atatgccaac tcttgctatg gtgaagcagg tgttagaaaa ttaattcaaa      240

atctaaagga tgaattagaa atggatatga gattgttggg tgtcactaaa atggaccagc      300

tatcttcgaa acatgtcgat actaaacgtt tgattggtag agatgcgatc aactatttgt      360

atgataatgt atacagccca atcgaaaccg ttaaattcaa caatgaagat tgattgttgg      420

aaatatatta ttcataaagg cgaaaacatt cccttggtat tttattccaa atttatgata      480

catagacgta ttttttatat ataaagttat attattaatg attcaagaaa aagttcaaat      540

aaactaatgg atcaacctat ttcgaccctt tcttcattgc tacttcttcc ttaagcaaca      600

gatgattaag tagatactgt ttttttagcc aatagtatct cgccgaggag ttatacttga      660

ctagctcttg ctcaagaatc ttcctaagac                                       690


<210>  3
<211>  572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cyb2b 5' Flank

<400>  3
agatgtatcc gtttggaatc tcatgacttt tggtgtgtgg tctgtgtctt cccagttatc       60

tacttgagtg attatgatcc agttttcacc attggttaca taccaaacag agaacttata      120

cgcaccagaa cgccttttgt gtctttttgt ttctcaagta tttctatcag tttccttcat      180

gtatcccggg actccattgt cctcggtagt gcctaccaat ttaatgtttg actccttgcg      240

ttttctcctg tcgcggacaa acggtgcggc tcccccgatg attcacgtaa taagccggag      300

tcaaccacag aggtccccta tgactcaaca aggcctcgta gaaactcggc ttctcggaga      360

aagagtcttt tctttttcac tggaaaatat ttttttttcc tttatattct tttgaaccaa      420

aatgtggcta ctataaaagt gcctttattc cccagctttt ctagcatgat tgagtcacct      480

tccacaatga gtcttcttta ttgttagtat tgtgaatatt atccgtgcag ttttcaagaa      540

cgtaaatcaa cagcagtgat aataccttca aa                                    572


<210>  4
<211>  499
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cyb2b 3' Flank

<400>  4
tctgatattt gctaaattga aatgaacctt accatgccac atctatagac atcaaaacca       60

ttttcaattt gtcgatatct tttgcatatc aaagtaatac caagcatgtt caaaaagaaa      120

agaaagcata actttaatac tctattcgaa acattccgat ccacaacaca ttagtctttt      180

taggcccgtt gttcatcttt ctattacttt attcctaact gtatttttat aattccgggt      240

ttataaaaga ttaaactaat atagcgcatt ctttttgggt acaaacatac ataacggagc      300

tcattcatac atcgcttttc agttcgactg gtgtttcgga tgcctctttt tctaaggagc      360

tagattctgg ccccacacta gtctttgaac tcgttgctcc cttaccaccc ttaccaccag      420

ccttacttgt aggtttttca gtagcatact ctgcgtgttt gactaaattc ccttccttaa      480

ctttgtgcca gcttggcca                                                   499


<210>  5
<211>  6517
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVL3 integration fragment

<400>  5
cccgccatga tggttgtatt ctaccaatga gacatggccg ctgatcctgt tgtgtgggtc       60

atgggacatc acctcttggg gaggattctc ctataattgg caccgtgtat gcctcaacca      120

ctaacttcca ccctataact gaatatatta cataagcaaa tctacttttt gtttgtgttg      180

atcgccatcg ttgaaattcg cgcaacttct ggtggctcaa cgctgctgtt ctatcggtat      240

cctaagagat gtctttgccc tgagtctagg gtaaactatc caccttcgtt gctgtttgac      300

tagacagcta ctaactttac ggtagtaaat gaataacggc tcgctctcat gatcacttct      360

ctacatcacc ctaacaagtg tattattttt tttcaggtgg gtgttgctgt tggtgctagc      420

cttagtgccc tcgttaatag ttgaacaaac actggcattt ggagtataat gaaaagggat      480

cactaccccc cgcttcctgt tccgcttctc ccttccggaa aaaccaccca ccctttcttt      540

tcccccacta atgtatgaat ttttccgttc ccaggggaat ggcccacttg gttctctgtt      600

aacccacaca attttgacgc atcccacaca cctttttttt tttctacccc acactttccc      660

ttgaaaaatc tccaatttga actggcaatt ttcacccccc accacttgca ttcattagtg      720

agtcaatcca tcccgcggtc ggagattcgg aatccaccta ctggtaatct gtaatctata      780

ttcccgctga cccttgtcga cttgctgcaa cggcaacatc aatgtccacg tttacacacc      840

tacatttata tctatattta tatttatatt tatttattta tgctacttag cttctatagt      900

tagttaatgc actcacgata ttcaaaattg acacccttca actactccct actattgtct      960

actactgtct actactcctc tttactatag ctgctcccaa taggctccac caataggctc     1020

tgtcaataca ttttgcgccg ccacctttca ggttgtgtca ctcctgaagg accatattgg     1080

gtaatcgtgc aatttctgga agagagtccg cgagaagtga ggcccccact gtaaatcctc     1140

gagggggcat ggagtatggg gcatggagga tggaggatgg ggggggggag aaaataggta     1200

gcgaaaggac ccgctatcac cccacccgga gaactcgttg ccgggaagtc atatttcgac     1260

actccgggga gtctataaaa ggcgggtttc gtcttttgcc agttgatgtt gctgagagga     1320

cttgtttgcc gtttcttccg atttaacagt atagaatcaa ccactgttaa ttatacacgt     1380

tatactaaca caacaaaaac aaaaacaacg acaacaacaa caacctgcag gatgaaaaac     1440

atcatttcat tagtttctaa gaagaaggct gcatccaaaa atgaagataa aaacatctct     1500

gaatcttcaa gagatatcgt taatcaacaa gaggttttca ataccgaaga tttcgaggaa     1560

ggcaaaaagg actctgcatt cgagttagat cacttggagt ttactaccaa ctccgcacaa     1620

ttaggcgact ctgatgagga caacgaaaac gtcattaacg aaatgaacgc aacagacgat     1680

gcaaacgaag caaactctga agagaaatcc atgaccttga agcaagcatt gttgaagtat     1740

cctaaagccg cattatggtc tattttagtc tccactactt tggtcatgga aggttacgac     1800

actgctttgt tatccgcatt atacgcttta ccagtttttc aacgtaagtt tggtacattg     1860

aatggtaaag gttcctatga gattacatcc caatggcaga ttggtcttaa catgtgcgtc     1920

ttgtgtggtg aaatgattgg tttacaaatc accacctata tggttgagtt tatgggtaac     1980

agatacacta tgatcaccgc tttaggtctt ttgactgctt acattttcat tttgtactat     2040

tgtaagtcct tagccatgat tgctgttggt caaattttgt ccgccatccc ttggggttgt     2100

tttcaatctt tggctgttac ctatgcttct gaagtctgcc cattagcact tagatactat     2160

atgacttcct attctaacat ttgctggttg ttcggccaaa tcttcgcatc tggtatcatg     2220

aaaaactcac aagagaactt aggcaattcc gatcttggtt acaaacttcc atttgcttta     2280

cagtggattt ggcctgcccc acttatgatt ggtattttct ttgctccaga atctccttgg     2340

tggcttgtta gaaaagatag agttgcagaa gctagaaagt cattatccag aattttgtct     2400

ggtaagggcg ctgaaaagga tattcaagtt gatcttacct taaagcagat tgaattaact     2460

attgaaaagg aaagattatt agcttctaag tctggttcat tctttaactg tttcaagggt     2520

gttaatggtc gtagaaccag attagcatgt ttaacctggg ttgcccaaaa ctcctccggt     2580

gcagttttgt taggttattc tacttacttt ttcgaaagag ctggtatggc aacagacaag     2640

gctttcacat tctcattaat ccagtactgt ttgggtcttg caggcacctt atgttcatgg     2700

gttatttcag gtagagtcgg tagatggact atcttgactt atggtcttgc ttttcaaatg     2760

gtctgtttgt tcattatcgg tggtatgggt tttggttctg gttcctctgc ttccaatggt     2820

gctggtggct tattgttggc attatccttt ttctacaatg caggcatcgg tgctgttgtc     2880

tattgtattg tcgccgaaat tccttcagca gaattgagaa ccaagactat tgttttggct     2940

agaatctgtt acaatttgat ggccgttatc aatgctattt tgaccccata catgttgaac     3000

gtttctgact ggaactgggg tgctaagaca ggcttgtatt ggggtggttt cactgcagtt     3060

actttggctt gggttattat cgacttacca gaaaccactg gtagaacatt ctctgaaatc     3120

aatgaattat tcaaccaagg tgttccagct cgtaagttcg catctactgt cgtcgatcca     3180

ttcggtaagg gtaagaccca acatgattcc ttggccgatg aatccatctc tcaatcttca     3240

tccattaagc aaagagaatt gaatgcagca gataagtgtt aacctgcagg cacgtccgac     3300

ggcggcccac gggtcccagg cctcggagat ccgtccccct tttcctttgt cgatatcatg     3360

taattagtta tgtcacgctt acattcacgc cctcccccca catccgctct aaccgaaaag     3420

gaaggagtta gacaacctga agtctaggtc cctatttatt tttttatagt tatgttagta     3480

ttaagaacgt tatttatatt tcaaattttt cttttttttc tgtacagacg cgtgtacgca     3540

tgtaacatta tactgaaaac cttgcttgag aaggttttgg gacgctcgaa ggctttaatt     3600

tgcaagctac tagtttcttt ccccctctca agctggcgtg aaatgcaacc ttacggcgtc     3660

tacgttacta caaggtccag aaagtgtagg tattgctact atttttattt tttattggtt     3720

ctggagaaat gcagacagtc aatgaacaca actgtctcaa tatgcatcta tgcacatgca     3780

cacacacaca catcacaggt acccctacaa agagaggtct cttgataatg tttcattacc     3840

acgtggcatc cccccccccc cccccaataa acaagtggcc gagttcccct gttgcagagg     3900

aggacaaaaa aaccgctggt gttggtacca ttatgcagca actagcacaa caaacaaccg     3960

acccagacat acaaatcaac aacacttcgc caaagacacc ctttccaggg aggatccact     4020

cccaacgtct ctccataatg tctctgttgg cccatgtctc tgtcgttgac accgtaacca     4080

caccaaccaa cccgtccatt gtactgggat ggtcgtccat agacacctct ccaacgggga     4140

acacctcatt cgtaaaccgc caaggttacc gttcctcctg actcgccccg ttgttgatgc     4200

tgcgcacctg tggttgccca acatggttgt atatcgtgta accacaccaa cacatgtgca     4260

gcacatgtgt ttaaaagagt gtcatggagg tggatcatga tggaagtgga ctttaccact     4320

tgggaactgt ctccactccc gggaagaaaa gacccggcgt atcacgcggt tgcctcaatg     4380

gggcaatttg gaaggagaaa tatagggaaa atcacgtcgc tctcggacgg ggaagagttc     4440

cagactatga gggggggggg tggtatataa agacaggaga tgtccacccc cagagagagg     4500

aagaagttgg aactttagaa gagagagata actttcccca gtgtccatca atacacaacc     4560

aaacacaaac tctatattta cacatataac cccctccaac caaacacata tgactatttc     4620

tgatcatcca gaaacagaac caaagtggtg gaaagaggcc acaatctatc aaatttaccc     4680

agcaagtttt aaagactcca ataacgatgg ctggggtgat ttaaaaggta tcacttccaa     4740

gttgcagtat attaaagatc ttggcgttga tgctatttgg gtttgtccgt tttatgactc     4800

tcctcaacaa gatatggggt atgatatatc taactacgaa aaggtctggc ccacatacgg     4860

taccaacgag gactgttttg agctaattga caagactcat aagctgggta tgaaattcat     4920

caccgatttg gttatcaacc actgttctac agaacacgaa tggttcaaag agagcagatc     4980

ctcgaagacc aatccgaagc gtgactggtt cttctggaga cctcctaaag gttatgacgc     5040

cgaaggcaag ccaattcctc caaacaattg gaaatctttc tttggtggtt cagcttggac     5100

ttttgatgaa actacaaatg aattttacct ccgtttgttt gcgagtcgtc aagttgactt     5160

gaattgggag aatgaagact gcagaagggc aatctttgaa agtgctgttg gattttggct     5220

ggaccatggt gtagatggtt ttagaatcga taccgctggt ttgtattcga aacgtcctgg     5280

tttaccagat tccccaattt ttgacaaaac ctcgaaatta caacatccaa attgggggtc     5340

tcacaatggt cctaggattc atgaatatca tcaagaacta cacagattta tgaaaaacag     5400

ggtgaaagat ggtagagaaa taatgacagt cggtgaagtt gcccatggaa gtgataatgc     5460

tttatacacc agtgcagcta gatacgaagt cagcgaagtt ttctccttca cgcacgttga     5520

agttggtacc tcgccatttt tccgttataa catagtgccc ttcaccttga aacaatggaa     5580

agaagccatt gcatcgaact ttttgttcat taacggtact gatagttggg ctaccaccta     5640

catcgagaat cacgatcaag cccggtcaat tacgagattt gctgacgatt cgccaaagta     5700

ccgtaaaata tctggtaagc tgttaacatt gctagaatgt tcattgacag gtacgttgta     5760

tgtctatcaa ggtcaggaga taggccagat caatttcaag gaatggccta ttgaaaagta     5820

tgaggacgtt gatgtgaaaa acaactacga gattatcaaa aaaagttttg gtaaaaactc     5880

gaaggaaatg aaggattttt ttaaaggaat cgccctactt tctagagatc attcgagaac     5940

tcccatgcca tggacgaaag ataagcccaa tgctggattt actggcccag atgttaaacc     6000

ttggtttttc ttgaatgaat cttttgagca aggaatcaat gttgagcagg aatccagaga     6060

tgatgactca gttctcaatt tttggaaaag ggccttgcaa gccagaaaga aatataagga     6120

gcttatgatt tatggttacg atttccaatt cattgattta gacagtgacc agatctttag     6180

cttcactaaa gagtacgaag acaagacgct gtttgctgct ttgaatttca gtggcgaaga     6240

aattgaattc agcctcccaa gagaaggtgc ttctttatct tttattcttg gaaattatga     6300

tgatactgac gtttcctcca gagttttgaa accatgggaa ggtagaatct acctcgtcaa     6360

ataacctgca ggttgttgga aatatattat tcataaaggc gaaaacattc ccttggtatt     6420

ttattccaaa tttatgatac atagacgtat tttttatata taaagttata ttattaatga     6480

ttcaagaaaa agttcaaata aactaatgga tcgggcc                              6517


<210>  6
<211>  584
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  6

Met Thr Ile Ser Asp His Pro Glu Thr Glu Pro Lys Trp Trp Lys Glu 
1               5                   10                  15      


Ala Thr Ile Tyr Gln Ile Tyr Pro Ala Ser Phe Lys Asp Ser Asn Asn 
            20                  25                  30          


Asp Gly Trp Gly Asp Leu Lys Gly Ile Thr Ser Lys Leu Gln Tyr Ile 
        35                  40                  45              


Lys Asp Leu Gly Val Asp Ala Ile Trp Val Cys Pro Phe Tyr Asp Ser 
    50                  55                  60                  


Pro Gln Gln Asp Met Gly Tyr Asp Ile Ser Asn Tyr Glu Lys Val Trp 
65                  70                  75                  80  


Pro Thr Tyr Gly Thr Asn Glu Asp Cys Phe Glu Leu Ile Asp Lys Thr 
                85                  90                  95      


His Lys Leu Gly Met Lys Phe Ile Thr Asp Leu Val Ile Asn His Cys 
            100                 105                 110         


Ser Thr Glu His Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr Asn 
        115                 120                 125             


Pro Lys Arg Asp Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp Ala 
    130                 135                 140                 


Glu Gly Lys Pro Ile Pro Pro Asn Asn Trp Lys Ser Phe Phe Gly Gly 
145                 150                 155                 160 


Ser Ala Trp Thr Phe Asp Glu Thr Thr Asn Glu Phe Tyr Leu Arg Leu 
                165                 170                 175     


Phe Ala Ser Arg Gln Val Asp Leu Asn Trp Glu Asn Glu Asp Cys Arg 
            180                 185                 190         


Arg Ala Ile Phe Glu Ser Ala Val Gly Phe Trp Leu Asp His Gly Val 
        195                 200                 205             


Asp Gly Phe Arg Ile Asp Thr Ala Gly Leu Tyr Ser Lys Arg Pro Gly 
    210                 215                 220                 


Leu Pro Asp Ser Pro Ile Phe Asp Lys Thr Ser Lys Leu Gln His Pro 
225                 230                 235                 240 


Asn Trp Gly Ser His Asn Gly Pro Arg Ile His Glu Tyr His Gln Glu 
                245                 250                 255     


Leu His Arg Phe Met Lys Asn Arg Val Lys Asp Gly Arg Glu Ile Met 
            260                 265                 270         


Thr Val Gly Glu Val Ala His Gly Ser Asp Asn Ala Leu Tyr Thr Ser 
        275                 280                 285             


Ala Ala Arg Tyr Glu Val Ser Glu Val Phe Ser Phe Thr His Val Glu 
    290                 295                 300                 


Val Gly Thr Ser Pro Phe Phe Arg Tyr Asn Ile Val Pro Phe Thr Leu 
305                 310                 315                 320 


Lys Gln Trp Lys Glu Ala Ile Ala Ser Asn Phe Leu Phe Ile Asn Gly 
                325                 330                 335     


Thr Asp Ser Trp Ala Thr Thr Tyr Ile Glu Asn His Asp Gln Ala Arg 
            340                 345                 350         


Ser Ile Thr Arg Phe Ala Asp Asp Ser Pro Lys Tyr Arg Lys Ile Ser 
        355                 360                 365             


Gly Lys Leu Leu Thr Leu Leu Glu Cys Ser Leu Thr Gly Thr Leu Tyr 
    370                 375                 380                 


Val Tyr Gln Gly Gln Glu Ile Gly Gln Ile Asn Phe Lys Glu Trp Pro 
385                 390                 395                 400 


Ile Glu Lys Tyr Glu Asp Val Asp Val Lys Asn Asn Tyr Glu Ile Ile 
                405                 410                 415     


Lys Lys Ser Phe Gly Lys Asn Ser Lys Glu Met Lys Asp Phe Phe Lys 
            420                 425                 430         


Gly Ile Ala Leu Leu Ser Arg Asp His Ser Arg Thr Pro Met Pro Trp 
        435                 440                 445             


Thr Lys Asp Lys Pro Asn Ala Gly Phe Thr Gly Pro Asp Val Lys Pro 
    450                 455                 460                 


Trp Phe Phe Leu Asn Glu Ser Phe Glu Gln Gly Ile Asn Val Glu Gln 
465                 470                 475                 480 


Glu Ser Arg Asp Asp Asp Ser Val Leu Asn Phe Trp Lys Arg Ala Leu 
                485                 490                 495     


Gln Ala Arg Lys Lys Tyr Lys Glu Leu Met Ile Tyr Gly Tyr Asp Phe 
            500                 505                 510         


Gln Phe Ile Asp Leu Asp Ser Asp Gln Ile Phe Ser Phe Thr Lys Glu 
        515                 520                 525             


Tyr Glu Asp Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser Gly Glu Glu 
    530                 535                 540                 


Ile Glu Phe Ser Leu Pro Arg Glu Gly Ala Ser Leu Ser Phe Ile Leu 
545                 550                 555                 560 


Gly Asn Tyr Asp Asp Thr Asp Val Ser Ser Arg Val Leu Lys Pro Trp 
                565                 570                 575     


Glu Gly Arg Ile Tyr Leu Val Lys 
            580                 


<210>  7
<211>  616
<212>  PRT
<213>  Saccharomyces cerevisieae (ScMAL11)

<400>  7

Met Lys Asn Ile Ile Ser Leu Val Ser Lys Lys Lys Ala Ala Ser Lys 
1               5                   10                  15      


Asn Glu Asp Lys Asn Ile Ser Glu Ser Ser Arg Asp Ile Val Asn Gln 
            20                  25                  30          


Gln Glu Val Phe Asn Thr Glu Asp Phe Glu Glu Gly Lys Lys Asp Ser 
        35                  40                  45              


Ala Phe Glu Leu Asp His Leu Glu Phe Thr Thr Asn Ser Ala Gln Leu 
    50                  55                  60                  


Gly Asp Ser Asp Glu Asp Asn Glu Asn Val Ile Asn Glu Met Asn Ala 
65                  70                  75                  80  


Thr Asp Asp Ala Asn Glu Ala Asn Ser Glu Glu Lys Ser Met Thr Leu 
                85                  90                  95      


Lys Gln Ala Leu Leu Lys Tyr Pro Lys Ala Ala Leu Trp Ser Ile Leu 
            100                 105                 110         


Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ala Leu Leu Ser 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Val Phe Gln Arg Lys Phe Gly Thr Leu Asn 
    130                 135                 140                 


Gly Lys Gly Ser Tyr Glu Ile Thr Ser Gln Trp Gln Ile Gly Leu Asn 
145                 150                 155                 160 


Met Cys Val Leu Cys Gly Glu Met Ile Gly Leu Gln Ile Thr Thr Tyr 
                165                 170                 175     


Met Val Glu Phe Met Gly Asn Arg Tyr Thr Met Ile Thr Ala Leu Gly 
            180                 185                 190         


Leu Leu Thr Ala Tyr Ile Phe Ile Leu Tyr Tyr Cys Lys Ser Leu Ala 
        195                 200                 205             


Met Ile Ala Val Gly Gln Ile Leu Ser Ala Ile Pro Trp Gly Cys Phe 
    210                 215                 220                 


Gln Ser Leu Ala Val Thr Tyr Ala Ser Glu Val Cys Pro Leu Ala Leu 
225                 230                 235                 240 


Arg Tyr Tyr Met Thr Ser Tyr Ser Asn Ile Cys Trp Leu Phe Gly Gln 
                245                 250                 255     


Ile Phe Ala Ser Gly Ile Met Lys Asn Ser Gln Glu Asn Leu Gly Asn 
            260                 265                 270         


Ser Asp Leu Gly Tyr Lys Leu Pro Phe Ala Leu Gln Trp Ile Trp Pro 
        275                 280                 285             


Ala Pro Leu Met Ile Gly Ile Phe Phe Ala Pro Glu Ser Pro Trp Trp 
    290                 295                 300                 


Leu Val Arg Lys Asp Arg Val Ala Glu Ala Arg Lys Ser Leu Ser Arg 
305                 310                 315                 320 


Ile Leu Ser Gly Lys Gly Ala Glu Lys Asp Ile Gln Val Asp Leu Thr 
                325                 330                 335     


Leu Lys Gln Ile Glu Leu Thr Ile Glu Lys Glu Arg Leu Leu Ala Ser 
            340                 345                 350         


Lys Ser Gly Ser Phe Phe Asn Cys Phe Lys Gly Val Asn Gly Arg Arg 
        355                 360                 365             


Thr Arg Leu Ala Cys Leu Thr Trp Val Ala Gln Asn Ser Ser Gly Ala 
    370                 375                 380                 


Val Leu Leu Gly Tyr Ser Thr Tyr Phe Phe Glu Arg Ala Gly Met Ala 
385                 390                 395                 400 


Thr Asp Lys Ala Phe Thr Phe Ser Leu Ile Gln Tyr Cys Leu Gly Leu 
                405                 410                 415     


Ala Gly Thr Leu Cys Ser Trp Val Ile Ser Gly Arg Val Gly Arg Trp 
            420                 425                 430         


Thr Ile Leu Thr Tyr Gly Leu Ala Phe Gln Met Val Cys Leu Phe Ile 
        435                 440                 445             


Ile Gly Gly Met Gly Phe Gly Ser Gly Ser Ser Ala Ser Asn Gly Ala 
    450                 455                 460                 


Gly Gly Leu Leu Leu Ala Leu Ser Phe Phe Tyr Asn Ala Gly Ile Gly 
465                 470                 475                 480 


Ala Val Val Tyr Cys Ile Val Ala Glu Ile Pro Ser Ala Glu Leu Arg 
                485                 490                 495     


Thr Lys Thr Ile Val Leu Ala Arg Ile Cys Tyr Asn Leu Met Ala Val 
            500                 505                 510         


Ile Asn Ala Ile Leu Thr Pro Tyr Met Leu Asn Val Ser Asp Trp Asn 
        515                 520                 525             


Trp Gly Ala Lys Thr Gly Leu Tyr Trp Gly Gly Phe Thr Ala Val Thr 
    530                 535                 540                 


Leu Ala Trp Val Ile Ile Asp Leu Pro Glu Thr Thr Gly Arg Thr Phe 
545                 550                 555                 560 


Ser Glu Ile Asn Glu Leu Phe Asn Gln Gly Val Pro Ala Arg Lys Phe 
                565                 570                 575     


Ala Ser Thr Val Val Asp Pro Phe Gly Lys Gly Lys Thr Gln His Asp 
            580                 585                 590         


Ser Leu Ala Asp Glu Ser Ile Ser Gln Ser Ser Ser Ile Lys Gln Arg 
        595                 600                 605             


Glu Leu Asn Ala Ala Asp Lys Cys 
    610                 615     


<210>  8
<211>  5906
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVL13 integration fragment

<400>  8
aaacctcggt agtgcctacc aatttaatgt ttgactcctt gcgttttctc ctgtcgcgga       60

caaacggtgc ggctcccccg atgattcacg taataagccg gagtcaacca cagaggtccc      120

ctatgactca acaaggcctc gtagaaactc ggcttctcgg agaaagagtc ttttcttttt      180

cactggaaaa tatttttttt tcctttatat tcttttgaac caaaatgtgg ctactataaa      240

agtgccttta ttccccagct tttctagcat gattgagtca ccttccacaa tgagtcttct      300

ttattgttag tattgtgaat attatccgtg cagttttcaa gaacgtaaat caacagcagt      360

gataatacct tcaaacatat ggataacttc gtataatgta tgctatacga agttatgctg      420

caacggcaac atcaatgtcc acgtttacac acctacattt atatctatat ttatatttat      480

atttatttat ttatgctact tagcttctat agttagttaa tgcactcacg atattcaaaa      540

ttgacaccct tcaactactc cctactattg tctactactg tctactactc ctctttacta      600

tagctgctcc caataggctc caccaatagg ctctgtcaat acattttgcg ccgccacctt      660

tcaggttgtg tcactcctga aggaccatat tgggtaatcg tgcaatttct ggaagagagt      720

gccgcgagaa gtgaggcccc cactgtaaat cctcgagggg gcatggagta tggggcatgg      780

aggatggagg atgggggggg ggggggaaaa taggtagcga aaggacccgc tatcacccca      840

cccggagaac tcgttgccgg gaagtcatat ttcgacactc cggggagtct ataaaaggcg      900

ggttttgtct tttgccagtt gatgttgctg agaggacttg tttgccgttt cttccgattt      960

aacagtatag aatcaaccac tgttaattat acacgttata ctaacacaac aaaaacaaaa     1020

acaacgacaa caacaacaac aatgtttgct ttctactttc tcaccgcatg caccactttg     1080

aagggtgttt tcggagtttc tccgagttac aatggtcttg gtctcacccc acagatgggt     1140

tgggacagct ggaatacgtt tgcctgcgat gtcagtgaac agctacttct agacactgct     1200

gatagaattt ctgacttggg gctaaaggat atgggttaca agtatgtcat cctagatgac     1260

tgttggtcta gcggcaggga ttccgacggt ttcctcgttg cagacaagca caaatttccc     1320

aacggtatgg gccatgttgc agaccacctg cataataaca gctttctttt cggtatgtat     1380

tcgtctgctg gtgagtacac ctgtgctggg taccctgggt ctctggggcg tgaggaagaa     1440

gatgctcaat tctttgcaaa taaccgcgtt gactacttga agtatgataa ttgttacaat     1500

aaaggtcaat ttggtacacc agacgtttct taccaccgtt acaaggccat gtcagatgct     1560

ttgaataaaa ctggtaggcc tattttctat tctctatgta actggggtca ggatttgaca     1620

ttttactggg gctctggtat cgccaattct tggagaatga gcggagatat tactgctgag     1680

ttcacccgtc cagatagcag atgtccctgt gacggtgacg aatatgattg caagtacgcc     1740

ggtttccatt gttctattat gaatattctt aacaaggcag ctccaatggg gcaaaatgca     1800

ggtgttggtg gttggaacga tctggacaat ctagaggtcg gagtcggtaa tttgactgac     1860

gatgaggaaa aggcccattt ctctatgtgg gcaatggtaa agtccccact tatcattggt     1920

gccgacgtga atcacttaaa ggcatcttcg tactcgatct acagtcaagc ctctgtcatc     1980

gcaattaatc aagatccaaa gggtattcca gccacaagag tctggagata ttatgtttca     2040

gacaccgatg aatatggaca aggtgaaatt caaatgtgga gtggtccgct tgacaatggt     2100

gaccaagtgg ttgctttatt gaatggagga agcgtagcaa gaccaatgaa cacgaccttg     2160

gaagagattt tctttgacag caatttgggt tcaaaggaac tgacatcgac ttgggatatt     2220

tacgacttat gggccaacag agttgacaac tctacggcgt ctgctatcct tgaacagaat     2280

aaggcagcca ccggtattct ctacaatgct acagagcagt cttataaaga cggtttgtct     2340

aagaatgata caagactgtt tggccagaaa attggtagtc tttctccaaa tgctatactt     2400

aacacaactg ttccagctca tggtatcgcc ttctataggt tgagaccctc ggcttaagct     2460

caatgttgag caaagcagga cgagaaaaaa aaaaataatg attgttaaga agttcatgaa     2520

aaaaaaaagg aaaaatactc aaatacttat aacagagtga ttaaataata aacggcagta     2580

taccctatca ggtattgaga tagttttatt tttgtaggta tataatctga agcctttgaa     2640

ctattttctc gtatatatca tggagtatac attgcattag caacattgca tactagttca     2700

taacttcgta taatgtatgc tatacgaagt tattaattaa caagggcgaa ttctgcagat     2760

atccatcaca ctggcggccg ctcgagcatg catctagagg gcccaattcg ccctatagtg     2820

aggccggccg tccaggagtc catcggttcc tgtcagatgg gatactcttg acgtggaaaa     2880

ttcaaacaga aaaaaaaccc ccaataatga aaaataatac tacgttatat ccgtggtatc     2940

ctctatcgta tcgtatcgta gcgtatcgta ccgtaccgta tcacagtata gtctaatatt     3000

ccgtatctta ttgtatccta tcctattcga tcctattgta tttctgtgca ccattttaat     3060

ttctattgct ataatgtcct tattagttgc cactgtgagg tgaccaatgg acgagggcga     3120

gccgttcaga agccgcgaag ggtgttcttc ccatgaattt cttaaggagg gcggctcagc     3180

tccgagagtg aggcgagacg tctcggttag cgtatccccc ttcctcggct tttacaaatg     3240

atgcgctctt aatagtgtgt cgttatcctt ttggcattga cgggggaggg aaattgattg     3300

agcgcatcca tattttggcg gactgctgag gacaatggtg gtttttccgg gtggcgtggg     3360

ctacaaatga tacgatggtt tttttctttt cggagaaggc gtataaaaag gacacggaga     3420

acccatttat tctaataaca gttgagcttc tttaattatt tgttaatata atattctatt     3480

attatatatt ttcttcccaa taaaacaaaa taaaacaaaa cacagcaaaa cacaaaaatt     3540

ctagacgcac gcgtatgact atctcttctg ctcacccaga aactgaacca aagtggtgga     3600

aagaggcaac tttttaccaa atctacccag cttcattcaa ggactccaat gatgatggtt     3660

ggggtgatat gaaaggtatt gcttccaaat tagaatacat taaggaatta ggtgccgatg     3720

ctatttggat ttctccattc tatgattctc cacaagacga tatgggttat gacatcgcta     3780

actatgaaaa ggtttggcca acctatggca ctaatgagga ctgttttgca ttaattgaga     3840

aaacccacaa gttgggcatg aagttcatta ctgatcttgt cattaatcat tgttcatccg     3900

aacatgaatg gttcaaggaa tccagatcct ccaaaactaa tccaaaaaga gattggtttt     3960

tctggagacc acctaagggt tatgatgctg aaggtaagcc aattccacca aacaattgga     4020

agtcttactt tggtggttcc gcatggacct tcgacgaaaa gacccaagag ttttacttga     4080

gattattctg ctccacccaa ccagatttga actgggaaaa tgaagattgt agaaaagcaa     4140

tctacgaatc tgcagttggc tattggttag atcacggtgt tgatggtttc agaattgatg     4200

ttggttcact ttactcaaag gttgttggtt tgccagatgc accagttgtt gataaaaact     4260

ctacatggca atcttctgac ccatacactc ttaatggtcc tagaatccat gaatttcatc     4320

aagagatgaa ccagttcatt agaaatagag ttaaggatgg tagagaaatt atgaccgttg     4380

gtgaaatgca acatgcatct gatgaaacta agagattata cacatcagcc tcccgtcacg     4440

aattgtctga attattcaac ttttcacaca cagacgttgg cacatcccca ttattccgtt     4500

ataacttggt tccattcgaa ttgaaggact ggaaaatcgc attggcagaa ttgtttagat     4560

atatcaatgg tactgattgt tggtctacca tctacttgga aaaccacgac caaccaagat     4620

ccatcactag attcggtgat gactctccta aaaaccgtgt catttctggt aagttacttt     4680

ctgtcttatt atccgcctta accggtactt tgtacgtcta tcaaggccag gaattgggtc     4740

aaattaactt taagaattgg ccagtcgaaa agtatgaaga tgtcgaaatc agaaacaact     4800

acaatgcaat taaggaggaa catggtgaaa attcagagga aatgaaaaag tttttggaag     4860

ctattgctct tatttccaga gatcacgcta gaaccccaat gcaatggtca agagaggaac     4920

ctaacgctgg tttctctggt ccttccgcca agccttggtt ttacttaaac gactccttca     4980

gagaaggtat taacgttgaa gatgaaatta aggacccaaa ttccgtcctt aacttctgga     5040

aggaagcatt gaagtttaga aaggcccata aggatattac cgtttatggt tatgactttg     5100

agtttatcga tttggataac aaaaagttat tctcattcac taaaaagtat aacaacaaga     5160

ccttattcgc tgctttaaac ttctcttctg atgctactga tttcaaaatt cctaatgacg     5220

attcctcttt caagttggag tttggtaact acccaaagaa ggaagttgac gcatcttctc     5280

gtacattgaa gccttgggaa ggtagaatct acatctccga gtaacctgca ggtttgccag     5340

cttactatcc ttcttgaaaa tatgcactct atatctttta gttcttaatt gcaacacata     5400

gatttgctgt ataacgaatt ttatgctatt ttttaaattt ggagttcagt gataaaagtg     5460

tcacagcgaa tttcctcaca tgtagggacc gaattgttta caagttctct gtaccaccat     5520

ggagacatca aaaattgaaa atctatggaa agatatggac ggtagcaaca agaatatagc     5580

acgagccggc gctagcgagc tcgtctgata tttgctaaat tgaaatgaac cttaccatgc     5640

cacatctata gacatcaaaa ccattttcaa tttgtcgata tcttttgcat atcaaagtaa     5700

taccaagcat gttcaaaaag aaaagaaagc ataactttaa tactctattc gaaacattcc     5760

gatccacaac acattagtct ttttaggccc gttgttcatc tttctattac tttattccta     5820

actgtatttt tataattccg ggtttataaa agattaaact aatatagcgc attctttttg     5880

ggtacaaaca tacataacgg aggttt                                          5906


<210>  9
<211>  589
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Thr Ile Ser Ser Ala His Pro Glu Thr Glu Pro Lys Trp Trp Lys 
1               5                   10                  15      


Glu Ala Thr Phe Tyr Gln Ile Tyr Pro Ala Ser Phe Lys Asp Ser Asn 
            20                  25                  30          


Asp Asp Gly Trp Gly Asp Met Lys Gly Ile Ala Ser Lys Leu Glu Tyr 
        35                  40                  45              


Ile Lys Glu Leu Gly Ala Asp Ala Ile Trp Ile Ser Pro Phe Tyr Asp 
    50                  55                  60                  


Ser Pro Gln Asp Asp Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val 
65                  70                  75                  80  


Trp Pro Thr Tyr Gly Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys 
                85                  90                  95      


Thr His Lys Leu Gly Met Lys Phe Ile Thr Asp Leu Val Ile Asn His 
            100                 105                 110         


Cys Ser Ser Glu His Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr 
        115                 120                 125             


Asn Pro Lys Arg Asp Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp 
    130                 135                 140                 


Ala Glu Gly Lys Pro Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Thr Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg 
                165                 170                 175     


Leu Phe Cys Ser Thr Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys 
            180                 185                 190         


Arg Lys Ala Ile Tyr Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly 
        195                 200                 205             


Val Asp Gly Phe Arg Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val 
    210                 215                 220                 


Gly Leu Pro Asp Ala Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser 
225                 230                 235                 240 


Ser Asp Pro Tyr Thr Leu Asn Gly Pro Arg Ile His Glu Phe His Gln 
                245                 250                 255     


Glu Met Asn Gln Phe Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile 
            260                 265                 270         


Met Thr Val Gly Glu Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu 
        275                 280                 285             


Tyr Thr Ser Ala Ser Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser 
    290                 295                 300                 


His Thr Asp Val Gly Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro 
305                 310                 315                 320 


Phe Glu Leu Lys Asp Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Tyr 
                325                 330                 335     


Ile Asn Gly Thr Asp Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp 
            340                 345                 350         


Gln Pro Arg Ser Ile Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg 
        355                 360                 365             


Val Ile Ser Gly Lys Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly 
    370                 375                 380                 


Thr Leu Tyr Val Tyr Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys 
385                 390                 395                 400 


Asn Trp Pro Val Glu Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr 
                405                 410                 415     


Asn Ala Ile Lys Glu Glu His Gly Glu Asn Ser Glu Glu Met Lys Lys 
            420                 425                 430         


Phe Leu Glu Ala Ile Ala Leu Ile Ser Arg Asp His Ala Arg Thr Pro 
        435                 440                 445             


Met Gln Trp Ser Arg Glu Glu Pro Asn Ala Gly Phe Ser Gly Pro Ser 
    450                 455                 460                 


Ala Lys Pro Trp Phe Tyr Leu Asn Asp Ser Phe Arg Glu Gly Ile Asn 
465                 470                 475                 480 


Val Glu Asp Glu Ile Lys Asp Pro Asn Ser Val Leu Asn Phe Trp Lys 
                485                 490                 495     


Glu Ala Leu Lys Phe Arg Lys Ala His Lys Asp Ile Thr Val Tyr Gly 
            500                 505                 510         


Tyr Asp Phe Glu Phe Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe 
        515                 520                 525             


Thr Lys Lys Tyr Asn Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser 
    530                 535                 540                 


Ser Asp Ala Thr Asp Phe Lys Ile Pro Asn Asp Asp Ser Ser Phe Lys 
545                 550                 555                 560 


Leu Glu Phe Gly Asn Tyr Pro Lys Lys Glu Val Asp Ala Ser Ser Arg 
                565                 570                 575     


Thr Leu Lys Pro Trp Glu Gly Arg Ile Tyr Ile Ser Glu 
            580                 585                 


<210>  10
<211>  6367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVL16 integration fragment

<400>  10
aaacctcggt agtgcctacc aatttaatgt ttgactcctt gcgttttctc ctgtcgcgga       60

caaacggtgc ggctcccccg atgattcacg taataagccg gagtcaacca cagaggtccc      120

ctatgactca acaaggcctc gtagaaactc ggcttctcgg agaaagagtc ttttcttttt      180

cactggaaaa tatttttttt tcctttatat tcttttgaac caaaatgtgg ctactataaa      240

agtgccttta ttccccagct tttctagcat gattgagtca ccttccacaa tgagtcttct      300

ttattgttag tattgtgaat attatccgtg cagttttcaa gaacgtaaat caacagcagt      360

gataatacct tcaaacatat gataacttcg tataatgtat gctatacgaa gttatgttgg      420

tggtgtgttt tgttggaacg tacattagat gcataatgcg tgacaccgcc atgatggttg      480

tattctacca atgagacatg gccgctgatc ctgttgtgtg ggtcatggga catcacctct      540

tgggggggat tctcctataa ttggcaccgt gtatgcctca accactaact tccaccctat      600

aactgaatat attacataag caaatctact ttttgtttgt gttgatcgcc atcgttgaaa      660

ttcgcgcaac ttctggtggc tcaacgctgc tgttctatcg gtatcctaag agatgtcttt      720

gccctgagtc tagggtaaac tatccacctt cgttgctgtt tgactagaca gctactaact      780

ttacggtagt aaatgaataa cggctcgctc tcatgatcac ttctctacat caccctaaca      840

agtgtattat ttttttttca ggtgggtgtt gctgttggtg ctagccttag tgccctcgtt      900

aatagttgaa caaacactgg catttggagt ataatgaaaa gggatcacta ccccccgctt      960

cctgttccgc ttctcccttc cggaaaaacc acccaccctt tcttttcccc cactaatgta     1020

tgaatttttc cgttcccagg ggaatggccc acttggttct ctgttaaccc acacaatttt     1080

gacgcatccc acacaccttt tttttttcta ccccacactt tcccttgaaa aatctccaat     1140

ttgaactggc aattttcacc ccccaccact tgcattcatt agtgagtcaa tccatcccgc     1200

ggtcggagat tcggaatcca cctactggta atctgtaatc tatattcccg ctgacccttt     1260

ataaatgaac tattgtcgtc aattgcggta gtgctccaac aaattgtaag gaccttcttt     1320

aaccttttcg attcaatcca tctccacata aacctagttg cacacaatgt tactcagatc     1380

actaaactct tctgctcgtt gtgtcaaaca aacaaccaga acaaaggtta ggtatctcag     1440

ccacgtcagt ggtgcaagca tggcgaaacc tacattgaag aacaactcga gagaatccaa     1500

caaatccaga aactatctaa ttgctgctgt gacagcattg gctgtatcaa cctcaattgg     1560

agttgccgta catgtgaagg accccttgta taacgatgct accggcagtg attctccgag     1620

aagtatatct gttgacgagt ttgtcaagca taattcacaa aacgactgtt ggattgcaat     1680

caatggcaag gtttatgatt tcactgattt tattccaaac catccaggtg gggtacctcc     1740

attagttaat catgctggtt atgatggtac taaactttat gagaaattgc atccaaaagg     1800

tacaattgag aaattcttgc caaaggataa gtttctgggt gtgttagatg gtgaagcgcc     1860

aaaattggaa gcagactatt tggtggacga tgatgaacaa gagagactgg attatttgaa     1920

caacttacct cctttgtcat ctattcagaa tgtttatgat ttcgaatact tggccaagaa     1980

gattttacct aaagatgcct gggcatatta ttcttgtggt gccgatgatg aaatcacaat     2040

gagagaaaac cattatgctt atcaaagagt ttatttcaga ccaagaattt gtgttgatgt     2100

caaggaagtt gatacttctt atgaaatgtt aggcactaaa acctctgttc ctttttatgt     2160

atctgccacc gctttggcta aattaggcca tcctgatggt gaatgctcaa ttgctagagg     2220

cgctggtaag gaaggtgtcg ttcaaatgat ttcgaccctt tcctcaatgt cattagatga     2280

aattgccgct gctagaattc caggtgcaac ccaatggttc caattataca ttaatgagga     2340

tagaaatgtc gctaaaggtc tggtcaaaca tgcagaagac ttgggtatga aggctatctt     2400

tataactgtt gatgctcctt ctctaggtaa cagagaaaag gataaaagat taaagtttgt     2460

taatgacacc gatgtcgatt tgggtgattc cgcagatcga aacagtggtg cttcaaaggc     2520

actatcttcg ttcattgatg cttctgtctc ttggaatgac gtcaaagcgg tcaagtcgtg     2580

gactaaattg cctgtcttag ttaaaggtgt tcaaacagtt gaagacgtta ttgaagctta     2640

cgatgctggt tgtcaaggtg ttgttttgtc aaaccacggt ggtaggcaac tagatactgc     2700

tcctcctcca atcgaattat tagctgaaac tgttccaact ttgaagagat tgggtaaatt     2760

aagaccagat tttgaaattt taattgacgg tggtgtcaaa agaggtaccg atattttgaa     2820

agcagtcgca atcggtggcc aagatgtcag agtttcagtt ggtatgggta gacctttctt     2880

atatgccaac tcttgctatg gtgaagcagg tgttagaaaa ttaattcaaa atctaaagga     2940

tgaattagaa atggatatga gattgttggg tgtcactaaa atggaccagc tatcttcgaa     3000

acatgtcgat actaaacgtt tgattggtag agatgcgatc aactatttgt atgataatgt     3060

atacagccca atcgaaaccg ttaaattcaa caatgaagat tgattgttgg aaatatatta     3120

ttcataaagg cgaaaacatt cccttggtat tttattccaa atttatgata catagacgta     3180

ttttttatat ataaagttat attattaatg attcaagaaa aagttcaaat aaactaatgg     3240

atcaaccata acttcgtata atgtatgcta tacgaagtta tagatctgcc gtccaggagt     3300

ccatcggttc ctgtcagatg ggatactctt gacgtggaaa attcaaacag aaaaaaaacc     3360

cccaataatg aaaaataata ctacgttata tccgtggtat cctctatcgt atcgtatcgt     3420

agcgtatcgt accgtaccgt atcacagtat agtctaatat tccgtatctt attgtatcct     3480

atcctattcg atcctattgt atttctgtgc accattttaa tttctattgc tataatgtcc     3540

ttattagttg ccactgtgag gtgaccaatg gacgagggcg agccgttcag aagccgcgaa     3600

gggtgttctt cccatgaatt tcttaaggag ggcggctcag ctccgagagt gaggcgagac     3660

gtctcggtta gcgtatcccc cttcctcggc ttttacaaat gatgcgctct taatagtgtg     3720

tcgttatcct tttggcattg acgggggagg gaaattgatt gagcgcatcc atattttggc     3780

ggactgctga ggacaatggt ggtttttccg ggtggcgtgg gctacaaatg atacgatggt     3840

ttttttcttt tcggagaagg cgtataaaaa ggacacggag aacccattta ttctaataac     3900

agttgagctt ctttaattat ttgttaatat aatattctat tattatatat tttcttccca     3960

ataaaacaaa ataaaacaaa acacagcaaa acacaaaaat tctagacgca cgcgtatgac     4020

tatctcttct gctcacccag aaactgaacc aaagtggtgg aaagaggcaa ctttttacca     4080

aatctaccca gcttcattca aggactccaa tgatgatggt tggggtgata tgaaaggtat     4140

tgcttccaaa ttagaataca ttaaggaatt aggtgccgat gctatttgga tttctccatt     4200

ctatgattct ccacaagacg atatgggtta tgacatcgct aactatgaaa aggtttggcc     4260

aacctatggc actaatgagg actgttttgc attaattgag aaaacccaca agttgggcat     4320

gaagttcatt actgatcttg tcattaatca ttgttcatcc gaacatgaat ggttcaagga     4380

atccagatcc tccaaaacta atccaaaaag agattggttt ttctggagac cacctaaggg     4440

ttatgatgct gaaggtaagc caattccacc aaacaattgg aagtcttact ttggtggttc     4500

cgcatggacc ttcgacgaaa agacccaaga gttttacttg agattattct gctccaccca     4560

accagatttg aactgggaaa atgaagattg tagaaaagca atctacgaat ctgcagttgg     4620

ctattggtta gatcacggtg ttgatggttt cagaattgat gttggttcac tttactcaaa     4680

ggttgttggt ttgccagatg caccagttgt tgataaaaac tctacatggc aatcttctga     4740

cccatacact cttaatggtc ctagaatcca tgaatttcat caagagatga accagttcat     4800

tagaaataga gttaaggatg gtagagaaat tatgaccgtt ggtgaaatgc aacatgcatc     4860

tgatgaaact aagagattat acacatcagc ctcccgtcac gaattgtctg aattattcaa     4920

cttttcacac acagacgttg gcacatcccc attattccgt tataacttgg ttccattcga     4980

attgaaggac tggaaaatcg cattggcaga attgtttaga tatatcaatg gtactgattg     5040

ttggtctacc atctacttgg aaaaccacga ccaaccaaga tccatcacta gattcggtga     5100

tgactctcct aaaaaccgtg tcatttctgg taagttactt tctgtcttat tatccgcctt     5160

aaccggtact ttgtacgtct atcaaggcca ggaattgggt caaattaact ttaagaattg     5220

gccagtcgaa aagtatgaag atgtcgaaat cagaaacaac tacaatgcaa ttaaggagga     5280

acatggtgaa aattcagagg aaatgaaaaa gtttttggaa gctattgctc ttatttccag     5340

agatcacgct agaaccccaa tgcaatggtc aagagaggaa cctaacgctg gtttctctgg     5400

tccttccgcc aagccttggt tttacttaaa cgactccttc agagaaggta ttaacgttga     5460

agatgaaatt aaggacccaa attccgtcct taacttctgg aaggaagcat tgaagtttag     5520

aaaggcccat aaggatatta ccgtttatgg ttatgacttt gagtttatcg atttggataa     5580

caaaaagtta ttctcattca ctaaaaagta taacaacaag accttattcg ctgctttaaa     5640

cttctcttct gatgctactg atttcaaaat tcctaatgac gattcctctt tcaagttgga     5700

gtttggtaac tacccaaaga aggaagttga cgcatcttct cgtacattga agccttggga     5760

aggtagaatc tacatctccg agtaacctgc aggtttgcca gcttactatc cttcttgaaa     5820

atatgcactc tatatctttt agttcttaat tgcaacacat agatttgctg tataacgaat     5880

tttatgctat tttttaaatt tggagttcag tgataaaagt gtcacagcga atttcctcac     5940

atgtagggac cgaattgttt acaagttctc tgtaccacca tggagacatc aaaaattgaa     6000

aatctatgga aagatatgga cggtagcaac aagaatatag cacgagccgg cgctagcgag     6060

ctcgtctgat atttgctaaa ttgaaatgaa ccttaccatg ccacatctat agacatcaaa     6120

accattttca atttgtcgat atcttttgca tatcaaagta ataccaagca tgttcaaaaa     6180

gaaaagaaag cataacttta atactctatt cgaaacattc cgatccacaa cacattagtc     6240

tttttaggcc cgttgttcat ctttctatta ctttattcct aactgtattt ttataattcc     6300

gggtttataa aagattaaac taatatagcg cattcttttt gggtacaaac atacataacg     6360

gaggttt                                                               6367


<210>  11
<211>  9630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVB32 plasmid


<220>
<221>  misc_feature
<222>  (5897)..(5897)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6283)..(6283)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6314)..(6314)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6343)..(6343)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6347)..(6347)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6371)..(6371)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6525)..(6525)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6543)..(6543)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7386)..(7386)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7397)..(7397)
<223>  n is a, c, g, or t

<400>  11
ctgacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga       60

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg      120

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat      180

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg      240

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata      300

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt      360

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat      420

ttaacgcgaa ttttaacaaa atattaacgc ttacaatttc cattcgccat tcaggctgcg      480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg      540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg      600

taaaacgacg gccagtgagc gcgcgtaata cgactcacta tagggcgaat tggtcgagga      660

gtccatcggt tcctgtcaga tgggatactc ttgacgtgga aaattcaaac agaaaaaaaa      720

ccccaataat gaaaaataac actacgttat atccgtggta tcctctatcg tatcgtatcg      780

tagcgtatcg tagcgtaccg tatcacagta tagtctaata ttccgtatct tattgtatcc      840

tatcctattc gatcctattg tatttcagtg caccatttta atttctattg ctataatgtc      900

cttattagtt gccactgtga ggtgaccaat ggacgagggc gagccgttca gaagccgcga      960

agggtgttct tcccatgaat ttcttaagga gggcggctca gctccgagag tgaggcgaga     1020

cgtctcggtc agcgtatccc ccttcctcgg cttttacaaa tgatgcgctc ttaatagtgt     1080

gtcgttatcc ttttggcatt gacgggggag ggaaattgat tgagcgcatc catatttttg     1140

cggactgctg aggacaatgg tggtttttcc gggtggcgtg ggctacaaat gatacgatgg     1200

tttttttctt ttcggagaag gcgtataaaa aggacacgga gaacccattt attctaaaaa     1260

cagttgagct tctttaatta ttttttgata taatattcta ttattatata ttttcttccc     1320

aataaaacaa aataaaacaa aacacagcaa aacacaaaaa ggatccatgt ctaatttact     1380

tactgttcac caaaacttgc ctgcattacc agttgacgca acctccgatg aagtcagaaa     1440

gaaccttatg gatatgttta gagatagaca agctttctcc gaacatactt ggaaaatgtt     1500

attatccgtt tgtagatcct gggccgcttg gtgtaaactt aacaatagaa aatggtttcc     1560

tgctgaacca gaagacgtca gagattactt actttactta caagctagag gtttggctgt     1620

taaaactatc caacaacact taggtcaatt gaatatgtta cacagaagat ccggtttacc     1680

aagaccatcc gattccaacg cagtttccct tgttatgaga agaattagaa aagaaaatgt     1740

tgacgctggt gaaagagcta aacaagcatt agcatttgaa agaaccgatt tcgatcaagt     1800

tagatcctta atggaaaatt ccgatagatg tcaagatatt agaaacttag ctttcttagg     1860

tattgcttac aacacattat taagaatcgc tgaaattgct agaattagag ttaaagatat     1920

ttcaagaacc gatggcggta gaatgttaat ccacattggc agaacaaaaa ccttagtctc     1980

cacagcaggc gtcgaaaaag cattatcatt aggtgttact aaattagttg aacgttggat     2040

ttccgtttcc ggtgttgcag atgacccaaa caactactta ttctgtcgtg ttagaaaaaa     2100

tggtgttgcc gctccttccg ctacctcaca attatccaca agagcattag aaggcatttt     2160

tgaagctacc cacagactta tttatggtgc aaaagacgat tccggtcaaa gatatttagc     2220

ttggtctggt cattccgcta gagttggtgc cgcaagagac atggcaagag ctggtgtttc     2280

tattcctgaa attatgcaag ccggtggttg gactaatgtt aacattgtta tgaactatat     2340

cagaaactta gattccgaaa caggtgctat ggttagatta cttgaagacg gtgattaagt     2400

taattaacat ctgaatgtaa aatgaacatt aaaatgaatt actaaacttt acgtctactt     2460

tacaatctat aaactttgtt taatcatata acgaaataca ctaatacaca atcctgtacg     2520

tatgtaatac ttttatccat caaggattga gaaaaaaaag taatgattcc ctgggccatt     2580

aaaacttaga cccccaagct tggataggtc actctctatt ttcgtttctc ccttccctga     2640

tagaagggtg atatgtaatt aagaataata tataatttta taataaaaga attcggcaga     2700

tctggatcga tcccccgggc tgcatgcaac ggcaacatca atgtccacgt ttacacacct     2760

acatttatat ctatatttat atttatattt atttatttat gctacttagc ttctatagtt     2820

agttaatgca ctcacgatat tcaaaattga cacccttcaa ctactcccta ctattgtcta     2880

ctactgtcta ctactcctct ttactatagc tgctcccaat aggctccacc aataggctct     2940

gtcaatacat tttgcgccgc cacctttcag gttgtgtcac tcctgaagga ccatattggg     3000

taatcgtgca atttctggaa gagagtgccg cgagaagtga ggcccccact gtaaatcctc     3060

gagggggcat ggagtatggg gcatggagga tggaggatgg gggggggggg ggaaaatagg     3120

tagcgaaagg acccgctatc accccacccg gagaactcgt tgccgggaag tcatatttcg     3180

acactccggg gagtctataa aaggcgggtt ttgtcttttg ccagttgatg ttgctgagag     3240

gacttgtttg ccgtttcttc cgatttaaca gtatagaatc aaccactgtt aattatacac     3300

gttatactaa cacaacaaaa acaaaaacaa cgacaacaac aacaacctgc aggaaatgct     3360

tttgcaagct ttccttttcc ttttggctgg ttttgcagcc aaaatatctg catcaatgac     3420

aaacgaaact agcgatagac ctttggtcca cttcacaccc aacaagggct ggatgaatga     3480

cccaaatggg ttgtggtacg atgaaaaaga tgccaaatgg catctgtact ttcaatacaa     3540

cccaaatgac accgtatggg gtacgccatt gttttggggc catgctactt ccgatgattt     3600

gactaattgg gaagatcaac ccattgctat cgctcccaag cgtaacgatt caggtgcttt     3660

ctctggctcc atggtggttg attacaacaa cacgagtggg tttttcaatg atactattga     3720

tccaagacaa agatgcgttg cgatttggac ttataacact cctgaaagtg aagagcaata     3780

cattagctat tctcttgatg gtggttacac ttttactgaa taccaaaaga accctgtttt     3840

agctgccaac tccactcaat tcagagatcc aaaggtgttc tggtatgaac cttctcaaaa     3900

atggattatg acggctgcca aatcacaaga ctacaaaatt gaaatttact cctctgatga     3960

cttgaagtcc tggaagctag aatctgcatt tgccaatgaa ggtttcttag gctaccaata     4020

cgaatgtcca ggtttgattg aagtcccaac tgagcaagat ccttccaaat cttattgggt     4080

catgtttatt tctatcaacc caggtgcacc tgctggcggt tccttcaacc aatattttgt     4140

tggatccttc aatggtactc attttgaagc gtttgacaat caatctagag tggtagattt     4200

tggtaaggac tactatgcct tgcaaacttt cttcaacact gacccaacct acggttcagc     4260

attaggtatt gcctgggctt caaactggga gtacagtgcc tttgtcccaa ctaacccatg     4320

gagatcatcc atgtctttgg tccgcaagtt ttctttgaac actgaatatc aagctaatcc     4380

agagactgaa ttgatcaatt tgaaagccga accaatattg aacattagta atgctggtcc     4440

ctggtctcgt tttgctacta acacaactct aactaaggcc aattcttaca atgtcgattt     4500

gagcaactcg actggtaccc tagagtttga gttggtttac gctgttaaca ccacacaaac     4560

catatccaaa tccgtctttg ccgacttatc actttggttc aagggtttag aagatcctga     4620

agaatatttg agaatgggtt ttgaagtcag tgcttcttcc ttctttttgg accgtggtaa     4680

ctctaaggtc aagtttgtca aggagaaccc atatttcaca aacagaatgt ctgtcaacaa     4740

ccaaccattc aagtctgaga acgacctaag ttactataaa gtgtacggcc tactggatca     4800

aaacatcttg gaattgtact tcaacgatgg agatgtggtt tctacaaata cctacttcat     4860

gaccaccggt aacgctctag gatctgtgaa catgaccact ggtgtcgata atttgttcta     4920

cattgacaag ttccaagtaa gggaagtaaa atagcctgca ggcacgtccg acggcggccc     4980

acgggtccca ggcctcggag atccgtcccc cttttccttt gtcgatatca tgtaattagt     5040

tatgtcacgc ttacattcac gccctccccc cacatccgct ctaaccgaaa aggaaggagt     5100

tagacaacct gaagtctagg tccctattta tttttttata gttatgttag tattaagaac     5160

gttatttata tttcaaattt ttcttttttt tctgtacaga cgcgtgtacg catgtaacat     5220

tatactgaaa accttgcttg agaaggtttt gggacgctcg aaggctttaa tttgcaagct     5280

gaattcccgg gccttaccgt cgacgaattt cagcattttc atttcaaggc gatattatgt     5340

ttcactaaac tcaggacagg aatatactaa gaataactac aacatacaca caacataagc     5400

caagatggat caacttaact accaagaaca acaacaattt caaaagatcg ttgaacaaaa     5460

gcaaatggct gatttcatga ggctatgaat tcgcccttga tctgggtgta tactgcacaa     5520

cctcattgtt cgggaatttg attctcatct cacatacagg cctgtagtat tgcgccctct     5580

ccttctcctt ctccttctcc ttctccaaga gagacttctc tctcatcgcc ctcgtcatca     5640

atggctgctc gctgtattgt cgttggagca tctcccgata cttctgcaac tgtgataaac     5700

tcatctcagg tgacccatcc gattctgtat cggtgtctcc atctggggct acatctcggg     5760

ccagtctaga tttaaacttt gcagaacctt cactttgggg gatatacact agtgtctctc     5820

ccgtgactac atcaccgaca ccctcaactg taccattatt attgtcattg ttttcctcta     5880

agttctcgct ttggtcntca tccatctctc cttcgggtgc tgtatcactc ttgatgattt     5940

ctctaaccct aatacggaga ctgtgattgc ctgaaataat acccacatct ttcaacttct     6000

gatgaagtga atctccagag atgaccttca tcagcacttg cacatcaacc acatcaccct     6060

ccttttgagc atccctcatg attccataga ctacatcccg tagcgtctcc ttgttcttgt     6120

acttcttaac aacagtctcg ccacagacat ggcccctgat aatcacctcc tgtctctcct     6180

catggccatc ctggtcgcca ttgtcttcgt cgctcggctc aattgccaat gtagcaccct     6240

gtggaagatt gcttagtctg tatggaacag actcatcaac tcntttgcca ttatgcatta     6300

acttgtactt tcgnccttgg ctaagttgaa aatgtttaca tcnwtcntca agtacattgg     6360

acatgattgt ncctgcattg acatttgtcc ggtaagtcct aaacccactc gctagattca     6420

ctgtaggcat attcaatcac gttccgtttg aaaaaaagga aaccaattta ttatctccag     6480

aaatagttgg cgtcttgcat cttgtttggt cttgatcttt cgtgnttttt tttttttctg     6540

tcnttttttt tctcctctct ccaacttttt gatttttagt gtaccaaatc gcactgctta     6600

tccacattca tcataaagrg ggggggagaa gaggggcaga aaataaaagg ccatgtcacg     6660

tgcctgtgca tttatttgtg tgtgtgtcac gtgctcaaaa tgtctttttt ttacgttttt     6720

aacattttcc ctttctgtag ttgaatccat ttgcatgagt cgtacatrat gtttgctgta     6780

tttacgttaa gacactaatt caaatgacaa acagctatta ttcttagcca ttaatgcatt     6840

tttgcaaatc tttaactgga tttaactatg gctaggtraa tttgttctgg acatcattgc     6900

cttgacttgt tttagtgccg atgtccttat cacttacact cgtaacacaa cacaacagca     6960

gctaatgttg ttgtgtatcg cttgaccctt aataactgat tcttttttga tgaatgttaa     7020

gaagaaacaa acaaraaaat aaaatcaaaa caggcttctt ttgacctctt tcaagagaag     7080

gttttcttgg ttgtttcata taccaagatc tgaatatctt ctattattat acaaaccact     7140

gattatacaa atctattcat cgacagtatg arctacgaaa acacactgat aaaragagtc     7200

atttcttccc cttctttttc tttttctttt tcttcttctt cttagtatcc ccatcttcat     7260

taactccacc aagtagatcc tctacacccc ccatggccgt taaaaaatgt tcacgaaaga     7320

aatccatatc attattctta ccatccatta aactgtttag atagatggtg atcatctccc     7380

ttgcantgtc tatatcntca acgtcgagta aatgcgacgc aatggtaccc agcttttgtt     7440

ccctttagtg agggttaatt gcgcgcttgg cgtaatcatg gtcatagctg tttcctgtgt     7500

gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag     7560

cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt     7620

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     7680

gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg cgctcggtcg     7740

ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat     7800

caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     7860

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     7920

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     7980

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     8040

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     8100

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     8160

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     8220

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     8280

cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta tttggtatct     8340

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     8400

aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa     8460

aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa     8520

actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt     8580

taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca     8640

gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca     8700

tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc     8760

ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa     8820

accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc     8880

agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca     8940

acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat     9000

tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag     9060

cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac     9120

tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt     9180

ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt     9240

gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc     9300

tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat     9360

ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca     9420

gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga     9480

cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg     9540

gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg     9600

ttccgcgcac atttccccga aaagtgccac                                      9630


<210>  12
<211>  4738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMI454 integration fragment

<400>  12
catagttgaa caaacactgg catttggagt ataatgaaaa gggatcacta ccccccgctt       60

cctgttccgc ttctcccttc cggaaaaacc acccaccctt tcttttcccc cactaatgta      120

tgaatttttc cgttcccagg ggaatggccc acttggttct ctgttaaccc acacaatttt      180

gacgcatccc acacaccttt tttttttcta ccccacactt tcccttgaaa aatctccaat      240

ttgaactggc aattttcacc ccccaccact tgcattcatt agtgagtcaa tccatcccgc      300

ggtcggagat tcggaatcca cctactggta atctgtaatc tatattcccg ctgacccttt      360

ataaatgaac tattgtcgtc aattgcggta gtgctccaac aaattgtaag gaccttcttt      420

aaccttttcg attcaatcca tctccacata aacctagttg cacacacctg cagggtacgt      480

agcatgcact cgcaagctgt gccatcgccc aacggttaat tataagaaat caacatcagc      540

caacaactat tttcgtcccc ctcttttcag tggtaacgag caattacatt agtaagagac      600

tattttcttc agtgatttgt aatttttttt cagtgatttg taattctttc tcgaaatatg      660

cgggcttaac ttatccggac attcactaca tgcaaggaaa aacgagaacc gcggagattt      720

cctcagtaag taacaatgat gatcttttta cgcttcatca tcactttcca aagttctaag      780

ctataagttc aagcctagat acgctgaaaa actcctgacc aacaatgtaa agaaaacaat      840

tacaattgta aggttgaaaa catctaaaaa tgaaatattt tattgtacat gcacaccctg      900

atagtcattc tcttacttca tccctgaaag acgtggctgt acaagagttg gaatcgcaag      960

gtcatgaggt taaagttagt gatctttatg ctcaaaagtg gaaggcctca atagaccgtg     1020

acgacttcga gcagcttttc gcaagaagag aggttaaaaa taccccaagc ttcttatgaa     1080

gcgtatgcca gaggagcatt aacaaaagac gtaaatcagg aacaggaaaa acttatttgg     1140

gcggactttg tcattttgtc gtttcctata tggtggtctt ctatgccggc tagtcgaccc     1200

cctcgagcga tctcgagatt tgctgcaacg gcaacatcaa tgtccacgtt tacacaccta     1260

catttatatc tatatttata tttatattta tttatttatg ctacttagct tctatagtta     1320

gttaatgcac tcacgatatt caaaattgac acccttcaac tactccctac tattgtctac     1380

tactgtctac tactcctctt tactatagct gctcccaata ggctccacca ataggctctg     1440

tcaatacatt ttgcgccgcc acctttcagg ttgtgtcact cctgaaggac catattgggt     1500

aatcgtgcaa tttctggaag agagtgccgc gagaagtgag gcccccactg taaatcctcg     1560

agggggcatg gagtatgggg catggaggat ggaggatggg gggggggggg gaaaataggt     1620

agcgaaagga cccgctatca ccccacccgg agaactcgtt gccgggaagt catatttcga     1680

cactccgggg agtctataaa aggcgggttt tgtcttttgc cagttgatgt tgctgagagg     1740

acttgtttgc cgtttcttcc gatttaacag tatagaatca accactgtta attatacacg     1800

ttatactaac acaacaaaaa caaaaacaac gacaacaaca acaacaatgt ttgctttcta     1860

ctttctcacc gcatgcacca ctttgaaggg tgttttcgga gtttctccga gttacaatgg     1920

tcttggtctc accccacaga tgggttggga cagctggaat acgtttgcct gcgatgtcag     1980

tgaacagcta cttctagaca ctgctgatag aatttctgac ttggggctaa aggatatggg     2040

ttacaagtat gtcatcctag atgactgttg gtctagcggc agggattccg acggtttcct     2100

cgttgcagac aagcacaaat ttcccaacgg tatgggccat gttgcagacc acctgcataa     2160

taacagcttt cttttcggta tgtattcgtc tgctggtgag tacacctgtg ctgggtaccc     2220

tgggtctctg gggcgtgagg aagaagatgc tcaattcttt gcaaataacc gcgttgacta     2280

cttgaagtat gataattgtt acaataaagg tcaatttggt acaccagacg tttcttacca     2340

ccgttacaag gccatgtcag atgctttgaa taaaactggt aggcctattt tctattctct     2400

atgtaactgg ggtcaggatt tgacatttta ctggggctct ggtatcgcca attcttggag     2460

aatgagcgga gatattactg ctgagttcac ccgtccagat agcagatgtc cctgtgacgg     2520

tgacgaatat gattgcaagt acgccggttt ccattgttct attatgaata ttcttaacaa     2580

ggcagctcca atggggcaaa atgcaggtgt tggtggttgg aacgatctgg acaatctaga     2640

ggtcggagtc ggtaatttga ctgacgatga ggaaaaggcc catttctcta tgtgggcaat     2700

ggtaaagtcc ccacttatca ttggtgccga cgtgaatcac ttaaaggcat cttcgtactc     2760

gatctacagt caagcctctg tcatcgcaat taatcaagat ccaaagggta ttccagccac     2820

aagagtctgg agatattatg tttcagacac cgatgaatat ggacaaggtg aaattcaaat     2880

gtggagtggt ccgcttgaca atggtgacca agtggttgct ttattgaatg gaggaagcgt     2940

agcaagacca atgaacacga ccttggaaga gattttcttt gacagcaatt tgggttcaaa     3000

ggaactgaca tcgacttggg atatttacga cttatgggcc aacagagttg acaactctac     3060

ggcgtctgct atccttgaac agaataaggc agccaccggt attctctaca atgctacaga     3120

gcagtcttat aaagacggtt tgtctaagaa tgatacaaga ctgtttggcc agaaaattgg     3180

tagtctttct ccaaatgcta tacttaacac aactgttcca gctcatggta tcgccttcta     3240

taggttgaga ccctcggctt aagctcaatg ttgagcaaag caggacgaga aaaaaaaaaa     3300

taatgattgt taagaagttc atgaaaaaaa aaaggaaaaa tactcaaata cttataacag     3360

agtgattaaa taataaacgg cagtataccc tatcaggtat tgagatagtt ttatttttgt     3420

aggtatataa tctgaagcct ttgaactatt ttctcgtata tatcatggag tatacattgc     3480

attagcaaca ttgcatacta gttctagagc ggccgatcca ctcgcaagct gtgccatcgc     3540

ccaacggtta attataagaa atcaacatca gccaacaact attttcgtcc ccctcttttc     3600

agtggtaacg agcaattaca ttagtaagag actattttct tcagtgattt gtaatttttt     3660

ttcagtgatt tgtaattctt tctcgaaata tgcgggctta acttatccgg acattcacta     3720

catgcaagga aaaacgagaa ccgcggagat ttcctcagta agtaacaatg atgatctttt     3780

tacgcttcat catcactttc caaagttcta agctataagt tcaagcctag atacgctgaa     3840

aaactcctga ccaacaatgt aaagaaaaca attacaattg taaggttgaa aacatctaaa     3900

aatgaaatat tttattgtac atgcacaccc tgatagtcat tctcttactt catccctgaa     3960

agacgtggct gtacaagagt tggaatcgca aggtcatgag gttaaagtta gtgatcttta     4020

tgctcaaaag tggaaggcct caatagaccg tgacgacttc gagcagcttt cgcaagaaga     4080

gaggttaaaa ataccccaag cttcttatga agcgtatgcc agaggagcat taacaaaaga     4140

cgtaaatcag gaacaggaaa aacttatttg ggcggacttt gtcattttgt cgtttcctat     4200

atggtggtct tctatgccgg ctacccgggg atatctagtt agatagctcc tcctccaatc     4260

gaattattag ctgaaactgt tccaactttg aagagattgg gtaaattaag accagatttt     4320

gaaattttaa ttgacggtgg tgtcaaaaga ggtaccgata ttttgaaagc agtcgcaatc     4380

ggtggccaag atgtcagagt ttcagttggt atgggtagac ctttcttata tgccaactct     4440

tgctatggtg aagcaggtgt tagaaaatta attcaaaatc taaaggatga attagaaatg     4500

gatatgagat tgttgggtgt cactaaaatg gaccagctat cttcgaaaca tgtcgatact     4560

aaacgtttga ttggtagaga tgcgatcaac tatttgtatg ataatgtata cagcccaatc     4620

gaaaccgtta aattcaacaa tgaagattga ttgttggaaa tatattattc ataaaggcga     4680

aaacattccc ttggtatttt attccaaatt tatgatacat agacgtaggg cccgagct       4738


<210>  13
<211>  6250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVL4 integration fragment

<400>  13
cccgccatga tggttgtatt ctaccaatga gacatggccg ctgatcctgt tgtgtgggtc       60

atgggacatc acctcttggg gaggattctc ctataattgg caccgtgtat gcctcaacca      120

ctaacttcca ccctataact gaatatatta cataagcaaa tctacttttt gtttgtgttg      180

atcgccatcg ttgaaattcg cgcaacttct ggtggctcaa cgctgctgtt ctatcggtat      240

cctaagagat gtctttgccc tgagtctagg gtaaactatc caccttcgtt gctgtttgac      300

tagacagcta ctaactttac ggtagtaaat gaataacggc tcgctctcat gatcacttct      360

ctacatcacc ctaacaagtg tattattttt tttcaggtgg gtgttgctgt tggtgctagc      420

cttagtgccc tcgttaatag ttgaacaaac actggcattt ggagtataat gaaaagggat      480

cactaccccc cgcttcctgt tccgcttctc ccttccggaa aaaccaccca ccctttcttt      540

tcccccacta atgtatgaat ttttccgttc ccaggggaat ggcccacttg gttctctgtt      600

aacccacaca attttgacgc atcccacaca cctttttttt tttctacccc acactttccc      660

ttgaaaaatc tccaatttga actggcaatt ttcacccccc accacttgca ttcattagtg      720

agtcaatcca tcccgcggtc ggagattcgg aatccaccta ctggtaatct gtaatctata      780

ttcccgctga cccttgtcga cttgctgcaa cggcaacatc aatgtccacg tttacacacc      840

tacatttata tctatattta tatttatatt tatttattta tgctacttag cttctatagt      900

tagttaatgc actcacgata ttcaaaattg acacccttca actactccct actattgtct      960

actactgtct actactcctc tttactatag ctgctcccaa taggctccac caataggctc     1020

tgtcaataca ttttgcgccg ccacctttca ggttgtgtca ctcctgaagg accatattgg     1080

gtaatcgtgc aatttctgga agagagtccg cgagaagtga ggcccccact gtaaatcctc     1140

gagggggcat ggagtatggg gcatggagga tggaggatgg ggggggggag aaaataggta     1200

gcgaaaggac ccgctatcac cccacccgga gaactcgttg ccgggaagtc atatttcgac     1260

actccgggga gtctataaaa ggcgggtttc gtcttttgcc agttgatgtt gctgagagga     1320

cttgtttgcc gtttcttccg atttaacagt atagaatcaa ccactgttaa ttatacacgt     1380

tatactaaca caacaaaaac aaaaacaacg acaacaacaa caacctgcag gatgaaaaac     1440

atcatttcat tagtttctaa gaagaaggct gcatccaaaa atgaagataa aaacatctct     1500

gaatcttcaa gagatatcgt taatcaacaa gaggttttca ataccgaaga tttcgaggaa     1560

ggcaaaaagg actctgcatt cgagttagat cacttggagt ttactaccaa ctccgcacaa     1620

ttaggcgact ctgatgagga caacgaaaac gtcattaacg aaatgaacgc aacagacgat     1680

gcaaacgaag caaactctga agagaaatcc atgaccttga agcaagcatt gttgaagtat     1740

cctaaagccg cattatggtc tattttagtc tccactactt tggtcatgga aggttacgac     1800

actgctttgt tatccgcatt atacgcttta ccagtttttc aacgtaagtt tggtacattg     1860

aatggtaaag gttcctatga gattacatcc caatggcaga ttggtcttaa catgtgcgtc     1920

ttgtgtggtg aaatgattgg tttacaaatc accacctata tggttgagtt tatgggtaac     1980

agatacacta tgatcaccgc tttaggtctt ttgactgctt acattttcat tttgtactat     2040

tgtaagtcct tagccatgat tgctgttggt caaattttgt ccgccatccc ttggggttgt     2100

tttcaatctt tggctgttac ctatgcttct gaagtctgcc cattagcact tagatactat     2160

atgacttcct attctaacat ttgctggttg ttcggccaaa tcttcgcatc tggtatcatg     2220

aaaaactcac aagagaactt aggcaattcc gatcttggtt acaaacttcc atttgcttta     2280

cagtggattt ggcctgcccc acttatgatt ggtattttct ttgctccaga atctccttgg     2340

tggcttgtta gaaaagatag agttgcagaa gctagaaagt cattatccag aattttgtct     2400

ggtaagggcg ctgaaaagga tattcaagtt gatcttacct taaagcagat tgaattaact     2460

attgaaaagg aaagattatt agcttctaag tctggttcat tctttaactg tttcaagggt     2520

gttaatggtc gtagaaccag attagcatgt ttaacctggg ttgcccaaaa ctcctccggt     2580

gcagttttgt taggttattc tacttacttt ttcgaaagag ctggtatggc aacagacaag     2640

gctttcacat tctcattaat ccagtactgt ttgggtcttg caggcacctt atgttcatgg     2700

gttatttcag gtagagtcgg tagatggact atcttgactt atggtcttgc ttttcaaatg     2760

gtctgtttgt tcattatcgg tggtatgggt tttggttctg gttcctctgc ttccaatggt     2820

gctggtggct tattgttggc attatccttt ttctacaatg caggcatcgg tgctgttgtc     2880

tattgtattg tcgccgaaat tccttcagca gaattgagaa ccaagactat tgttttggct     2940

agaatctgtt acaatttgat ggccgttatc aatgctattt tgaccccata catgttgaac     3000

gtttctgact ggaactgggg tgctaagaca ggcttgtatt ggggtggttt cactgcagtt     3060

actttggctt gggttattat cgacttacca gaaaccactg gtagaacatt ctctgaaatc     3120

aatgaattat tcaaccaagg tgttccagct cgtaagttcg catctactgt cgtcgatcca     3180

ttcggtaagg gtaagaccca acatgattcc ttggccgatg aatccatctc tcaatcttca     3240

tccattaagc aaagagaatt gaatgcagca gataagtgtt aacctgcagg cacgtccgac     3300

ggcggcccac gggtcccagg cctcggagat ccgtccccct tttcctttgt cgatatcatg     3360

taattagtta tgtcacgctt acattcacgc cctcccccca catccgctct aaccgaaaag     3420

gaaggagtta gacaacctga agtctaggtc cctatttatt tttttatagt tatgttagta     3480

ttaagaacgt tatttatatt tcaaattttt cttttttttc tgtacagacg cgtgtacgca     3540

tgtaacatta tactgaaaac cttgcttgag aaggttttgg gacgctcgaa ggctttaatt     3600

tgcaagctac tagcgcaggg ataacttcgt ataatgtatg ctatacgaag ttatgctgca     3660

acggcaacat caatgtccac gtttacacac ctacatttat atctatattt atatttatat     3720

ttatttattt atgctactta gcttctatag ttagttaatg cactcacgat attcaaaatt     3780

gacacccttc aactactccc tactattgtc tactactgtc tactactcct ctttactata     3840

gctgctccca ataggctcca ccaataggct ctgtcaatac attttgcgcc gccacctttc     3900

aggttgtgtc actcctgaag gaccatattg ggtaatcgtg caatttctgg aagagagtcc     3960

gcgagaagtg aggcccccac tgtaaatcct cgagggggca tggagtatgg ggcatggagg     4020

atggaggatg gggggggggg aaaataggta gcgaaaggac ccgctatcac cccacccgga     4080

gaactcgttg ccgggaagtc atatttcgac actccgggga gtctataaaa ggcgggtttt     4140

gtcttttgcc agttgatgtt gctgagagga cttgtttgcc gtttcttccg atttaacagt     4200

atagaatcaa ccactgttaa ttatacacgt tatactaaca caacaaaaac aaaaacaacg     4260

acaacaacaa caacaatgtt tgctttctac tttctcaccg catgcaccac tttgaagggt     4320

gttttcggag tttctccgag ttacaatggt cttggtctca ccccacagat gggttgggac     4380

agctggaata cgtttgcctg cgatgtcagt gaacagctac ttctagacac tgctgataga     4440

atttctgact tggggctaaa ggatatgggt tacaagtatg tcatcctaga tgactgttgg     4500

tctagcggca gggattccga cggtttcctc gttgcagaca agcacaaatt tcccaacggt     4560

atgggccatg ttgcagacca cctgcataat aacagctttc ttttcggtat gtattcgtct     4620

gctggtgagt acacctgtgc tgggtaccct gggtctctgg ggcgtgagga agaagatgct     4680

caattctttg caaataaccg cgttgactac ttgaagtatg ataattgtta caataaaggt     4740

caatttggta caccagacgt ttcttaccac cgttacaagg ccatgtcaga tgctttgaat     4800

aaaactggta ggcctatttt ctattctcta tgtaactggg gtcaggattt gacattttac     4860

tggggctctg gtatcgccaa ttcttggaga atgagcggag atattactgc tgagttcacc     4920

cgtccagata gcagatgtcc ctgtgacggt gacgaatatg attgcaagta cgccggtttc     4980

cattgttcta ttatgaatat tcttaacaag gcagctccaa tggggcaaaa tgcaggtgtt     5040

ggtggttgga acgatctgga caatctagag gtcggagtcg gtaatttgac tgacgatgag     5100

gaaaaggccc atttctctat gtgggcaatg gtaaagtccc cacttatcat tggtgccgac     5160

gtgaatcact taaaggcatc ttcgtactcg atctacagtc aagcctctgt catcgcaatt     5220

aatcaagatc caaagggtat tccagccaca agagtctgga gatattatgt ttcagacacc     5280

gatgaatatg gacaaggtga aattcaaatg tggagtggtc cgcttgacaa tggtgaccaa     5340

gtggttgctt tattgaatgg aggaagcgta gcaagaccaa tgaacacgac cttggaagag     5400

attttctttg acagcaattt gggttcaaag gaactgacat cgacttggga tatttacgac     5460

ttatgggcca acagagttga caactctacg gcgtctgcta tccttgaaca gaataaggca     5520

gccaccggta ttctctacaa tgctacagag cagtcttata aagacggttt gtctaagaat     5580

gatacaagac tgtttggcca gaaaattggt agtctttctc caaatgctat acttaacaca     5640

actgttccag ctcatggtat cgccttctat aggttgagac cctcggctta agctcaatgt     5700

tgagcaaagc aggacgagaa aaaaaaaaat aatgattgtt aagaagttca tgaaaaaaaa     5760

aagaaaaaat actcaaatac ttataacaga gtgattaaat aataaacgac agtataccct     5820

atcaggtatt cagatagttt tatttttgta ggtatataat ctgaagcctt tgaactattt     5880

tctcgtatat atcatggagt atacattgca ttagcaacat tgcatactag ttcataactt     5940

cgtataatgt atgctatacg aagttattaa ttaacaaggg cgaattcagc ctcccaagag     6000

aaggtgcttc tttatctttt attcttggaa attatgatga tactgacgtt tcctccagag     6060

ttttgaaacc atgggaaggt agaatctacc tcgtcaaata acctgcaggt tgttggaaat     6120

atattattca taaaggcgaa aacattccct tggtatttta ttccaaattt atgatacata     6180

gacgtatttt ttatatataa agttatatta ttaatgattc aagaaaaagt tcaaataaac     6240

taatggatcg                                                            6250


<210>  14
<211>  5906
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVL14 integration fragment

<400>  14
aaacctcggt agtgcctacc aatttaatgt ttgactcctt gcgttttctc ctgtcgcgga       60

caaacggtgc ggctcccccg atgattcacg taataagccg gagtcaacca cagaggtccc      120

ctatgactca acaaggcctc gtagaaactc ggcttctcgg agaaagagtc ttttcttttt      180

cactggaaaa tatttttttt tcctttatat tcttttgaac caaaatgtgg ctactataaa      240

agtgccttta ttccccagct tttctagcat gattgagtca ccttccacaa tgagtcttct      300

ttattgttag tattgtgaat attatccgtg cagttttcaa gaacgtaaat caacagcagt      360

gataatacct tcaaacatat ggataacttc gtataatgta tgctatacga agttatgctg      420

caacggcaac atcaatgtcc acgtttacac acctacattt atatctatat ttatatttat      480

atttatttat ttatgctact tagcttctat agttagttaa tgcactcacg atattcaaaa      540

ttgacaccct tcaactactc cctactattg tctactactg tctactactc ctctttacta      600

tagctgctcc caataggctc caccaatagg ctctgtcaat acattttgcg ccgccacctt      660

tcaggttgtg tcactcctga aggaccatat tgggtaatcg tgcaatttct ggaagagagt      720

gccgcgagaa gtgaggcccc cactgtaaat cctcgagggg gcatggagta tggggcatgg      780

aggatggagg atgggggggg ggggggaaaa taggtagcga aaggacccgc tatcacccca      840

cccggagaac tcgttgccgg gaagtcatat ttcgacactc cggggagtct ataaaaggcg      900

ggttttgtct tttgccagtt gatgttgctg agaggacttg tttgccgttt cttccgattt      960

aacagtatag aatcaaccac tgttaattat acacgttata ctaacacaac aaaaacaaaa     1020

acaacgacaa caacaacaac aatgtttgct ttctactttc tcaccgcatg caccactttg     1080

aagggtgttt tcggagtttc tccgagttac aatggtcttg gtctcacccc acagatgggt     1140

tgggacagct ggaatacgtt tgcctgcgat gtcagtgaac agctacttct agacactgct     1200

gatagaattt ctgacttggg gctaaaggat atgggttaca agtatgtcat cctagatgac     1260

tgttggtcta gcggcaggga ttccgacggt ttcctcgttg cagacaagca caaatttccc     1320

aacggtatgg gccatgttgc agaccacctg cataataaca gctttctttt cggtatgtat     1380

tcgtctgctg gtgagtacac ctgtgctggg taccctgggt ctctggggcg tgaggaagaa     1440

gatgctcaat tctttgcaaa taaccgcgtt gactacttga agtatgataa ttgttacaat     1500

aaaggtcaat ttggtacacc agacgtttct taccaccgtt acaaggccat gtcagatgct     1560

ttgaataaaa ctggtaggcc tattttctat tctctatgta actggggtca ggatttgaca     1620

ttttactggg gctctggtat cgccaattct tggagaatga gcggagatat tactgctgag     1680

ttcacccgtc cagatagcag atgtccctgt gacggtgacg aatatgattg caagtacgcc     1740

ggtttccatt gttctattat gaatattctt aacaaggcag ctccaatggg gcaaaatgca     1800

ggtgttggtg gttggaacga tctggacaat ctagaggtcg gagtcggtaa tttgactgac     1860

gatgaggaaa aggcccattt ctctatgtgg gcaatggtaa agtccccact tatcattggt     1920

gccgacgtga atcacttaaa ggcatcttcg tactcgatct acagtcaagc ctctgtcatc     1980

gcaattaatc aagatccaaa gggtattcca gccacaagag tctggagata ttatgtttca     2040

gacaccgatg aatatggaca aggtgaaatt caaatgtgga gtggtccgct tgacaatggt     2100

gaccaagtgg ttgctttatt gaatggagga agcgtagcaa gaccaatgaa cacgaccttg     2160

gaagagattt tctttgacag caatttgggt tcaaaggaac tgacatcgac ttgggatatt     2220

tacgacttat gggccaacag agttgacaac tctacggcgt ctgctatcct tgaacagaat     2280

aaggcagcca ccggtattct ctacaatgct acagagcagt cttataaaga cggtttgtct     2340

aagaatgata caagactgtt tggccagaaa attggtagtc tttctccaaa tgctatactt     2400

aacacaactg ttccagctca tggtatcgcc ttctataggt tgagaccctc ggcttaagct     2460

caatgttgag caaagcagga cgagaaaaaa aaaaataatg attgttaaga agttcatgaa     2520

aaaaaaaagg aaaaatactc aaatacttat aacagagtga ttaaataata aacggcagta     2580

taccctatca ggtattgaga tagttttatt tttgtaggta tataatctga agcctttgaa     2640

ctattttctc gtatatatca tggagtatac attgcattag caacattgca tactagttca     2700

taacttcgta taatgtatgc tatacgaagt tattaattaa caagggcgaa ttctgcagat     2760

atccatcaca ctggcggccg ctcgagcatg catctagagg gcccaattcg ccctatagtg     2820

aggccggccg tccaggagtc catcggttcc tgtcagatgg gatactcttg acgtggaaaa     2880

ttcaaacaga aaaaaaaccc ccaataatga aaaataatac tacgttatat ccgtggtatc     2940

ctctatcgta tcgtatcgta gcgtatcgta ccgtaccgta tcacagtata gtctaatatt     3000

ccgtatctta ttgtatccta tcctattcga tcctattgta tttctgtgca ccattttaat     3060

ttctattgct ataatgtcct tattagttgc cactgtgagg tgaccaatgg acgagggcga     3120

gccgttcaga agccgcgaag ggtgttcttc ccatgaattt cttaaggagg gcggctcagc     3180

tccgagagtg aggcgagacg tctcggttag cgtatccccc ttcctcggct tttacaaatg     3240

atgcgctctt aatagtgtgt cgttatcctt ttggcattga cgggggaggg aaattgattg     3300

agcgcatcca tattttggcg gactgctgag gacaatggtg gtttttccgg gtggcgtggg     3360

ctacaaatga tacgatggtt tttttctttt cggagaaggc gtataaaaag gacacggaga     3420

acccatttat tctaataaca gttgagcttc tttaattatt tgttaatata atattctatt     3480

attatatatt ttcttcccaa taaaacaaaa taaaacaaaa cacagcaaaa cacaaaaatt     3540

ctagacgcac gcgtatgact atttcttctg cacatccaga gacagaacca aagtggtgga     3600

aagaggccac gttctatcaa atttacccag caagtttcaa agactctaat gacgatggct     3660

ggggtgatat gaagggtatt tcctccaagt tggagtatat caaggagctt ggtgtcgatg     3720

ccatttggat ctcaccattc tacgactcgc cacaagatga tatgggttac gatattgcca     3780

actacgaaaa ggtctggcca acctacggta cgaacgagga ctgctttgcc ttgatcgaaa     3840

agacacataa acttggtatg aaatttatca ccgacttggt catcaatcac tgttccagcg     3900

aacatgaatg gttcaaagag agcagatcct cgaagaccaa tccgaagcgt gactggttct     3960

tctggagacc tcctaagggt tatgacgccg aaggcaagcc aattcctcca aataattgga     4020

agtcctattt tggtggttcc gcatggacct tcgatgaaaa gacacaagaa ttctacttgc     4080

gtttgttttg ctccactcaa cctgatttga attgggagaa tgaagactgt agaaaggcaa     4140

tctacgaaag tgccgttgga tactggttag accatggtgt agacggcttt agaattgatg     4200

tcggaagttt gtactccaaa gttgtaggtt taccagatgc ccctgttgtt gacaaaaacc     4260

cgacttggca atccagtgat ccatacacat tgaatggacc acgtattcac gagttccatc     4320

aagaaatgaa tcaattcatc agaaacagag tgaaggatgg cagggagatt atgacagttg     4380

gtgaaatgca acatgcttcc gacgaaacta agagacttta tacgagtgct tcaagacacg     4440

aacttagtga gttatttaac ttttcccaca ctgatgtggg gacttcacct ttgttccgtt     4500

acaacttggt cccatttgaa ctgaaggatt ggaagattgc ccttgctgag ctgttcaggt     4560

tcattaatgg tacagattgt tggtcaacaa tctatctgga aaatcacgac caacctcgtt     4620

caattacgag atttggtgac gattctccta agaaccgtgt tatttctggt aagttactct     4680

ctgtgttgct aagtgccttg accggtactc tatatgtgta tcagggacaa gagcttggcc     4740

aaatcaattt caagaactgg cctgttgaaa agtacgagga tgtcgaaatc agaaacaact     4800

acaatgcaat taaagaagag catggggaaa actcagagga gatgaaaaag tttttagaag     4860

ccattgccat tatctccagg gaccatgcta gaacacctat gcaatggtct cgtgaggagc     4920

caaatgctgg tttttctggt cctagtgcta aaccatggtt ttacttgaac gactctttca     4980

gagaaggcat taacgtcgaa gatgaaatca aggatcccaa ctcggttttg aacttctgga     5040

aggaggcctt gaagtttaga aaggcgcata aagacattac tgtgtacgga tacgattttg     5100

agtttattga tttagacaat aagaagttgt ttagcttcac aaagaagtac aacaataaaa     5160

cattgtttgc ggccttgaac tttagctctg atgcgacaga tttcaagatt ccaaatgatg     5220

attcatcgtt caagttagag tttggaaact atccaaagaa ggaggtagat gcctcttcca     5280

gaacattgaa gccatgggaa ggaagaatat atatcagcga atgacctgca ggtttgccag     5340

cttactatcc ttcttgaaaa tatgcactct atatctttta gttcttaatt gcaacacata     5400

gatttgctgt ataacgaatt ttatgctatt ttttaaattt ggagttcagt gataaaagtg     5460

tcacagcgaa tttcctcaca tgtagggacc gaattgttta caagttctct gtaccaccat     5520

ggagacatca aaaattgaaa atctatggaa agatatggac ggtagcaaca agaatatagc     5580

acgagccggc gctagcgagc tcgtctgata tttgctaaat tgaaatgaac cttaccatgc     5640

cacatctata gacatcaaaa ccattttcaa tttgtcgata tcttttgcat atcaaagtaa     5700

taccaagcat gttcaaaaag aaaagaaagc ataactttaa tactctattc gaaacattcc     5760

gatccacaac acattagtct ttttaggccc gttgttcatc tttctattac tttattccta     5820

actgtatttt tataattccg ggtttataaa agattaaact aatatagcgc attctttttg     5880

ggtacaaaca tacataacgg aggttt                                          5906


<210>  15
<211>  6367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVL17 integration fragment

<400>  15
aaacctcggt agtgcctacc aatttaatgt ttgactcctt gcgttttctc ctgtcgcgga       60

caaacggtgc ggctcccccg atgattcacg taataagccg gagtcaacca cagaggtccc      120

ctatgactca acaaggcctc gtagaaactc ggcttctcgg agaaagagtc ttttcttttt      180

cactggaaaa tatttttttt tcctttatat tcttttgaac caaaatgtgg ctactataaa      240

agtgccttta ttccccagct tttctagcat gattgagtca ccttccacaa tgagtcttct      300

ttattgttag tattgtgaat attatccgtg cagttttcaa gaacgtaaat caacagcagt      360

gataatacct tcaaacatat gataacttcg tataatgtat gctatacgaa gttatgttgg      420

tggtgtgttt tgttggaacg tacattagat gcataatgcg tgacaccgcc atgatggttg      480

tattctacca atgagacatg gccgctgatc ctgttgtgtg ggtcatggga catcacctct      540

tgggggggat tctcctataa ttggcaccgt gtatgcctca accactaact tccaccctat      600

aactgaatat attacataag caaatctact ttttgtttgt gttgatcgcc atcgttgaaa      660

ttcgcgcaac ttctggtggc tcaacgctgc tgttctatcg gtatcctaag agatgtcttt      720

gccctgagtc tagggtaaac tatccacctt cgttgctgtt tgactagaca gctactaact      780

ttacggtagt aaatgaataa cggctcgctc tcatgatcac ttctctacat caccctaaca      840

agtgtattat ttttttttca ggtgggtgtt gctgttggtg ctagccttag tgccctcgtt      900

aatagttgaa caaacactgg catttggagt ataatgaaaa gggatcacta ccccccgctt      960

cctgttccgc ttctcccttc cggaaaaacc acccaccctt tcttttcccc cactaatgta     1020

tgaatttttc cgttcccagg ggaatggccc acttggttct ctgttaaccc acacaatttt     1080

gacgcatccc acacaccttt tttttttcta ccccacactt tcccttgaaa aatctccaat     1140

ttgaactggc aattttcacc ccccaccact tgcattcatt agtgagtcaa tccatcccgc     1200

ggtcggagat tcggaatcca cctactggta atctgtaatc tatattcccg ctgacccttt     1260

ataaatgaac tattgtcgtc aattgcggta gtgctccaac aaattgtaag gaccttcttt     1320

aaccttttcg attcaatcca tctccacata aacctagttg cacacaatgt tactcagatc     1380

actaaactct tctgctcgtt gtgtcaaaca aacaaccaga acaaaggtta ggtatctcag     1440

ccacgtcagt ggtgcaagca tggcgaaacc tacattgaag aacaactcga gagaatccaa     1500

caaatccaga aactatctaa ttgctgctgt gacagcattg gctgtatcaa cctcaattgg     1560

agttgccgta catgtgaagg accccttgta taacgatgct accggcagtg attctccgag     1620

aagtatatct gttgacgagt ttgtcaagca taattcacaa aacgactgtt ggattgcaat     1680

caatggcaag gtttatgatt tcactgattt tattccaaac catccaggtg gggtacctcc     1740

attagttaat catgctggtt atgatggtac taaactttat gagaaattgc atccaaaagg     1800

tacaattgag aaattcttgc caaaggataa gtttctgggt gtgttagatg gtgaagcgcc     1860

aaaattggaa gcagactatt tggtggacga tgatgaacaa gagagactgg attatttgaa     1920

caacttacct cctttgtcat ctattcagaa tgtttatgat ttcgaatact tggccaagaa     1980

gattttacct aaagatgcct gggcatatta ttcttgtggt gccgatgatg aaatcacaat     2040

gagagaaaac cattatgctt atcaaagagt ttatttcaga ccaagaattt gtgttgatgt     2100

caaggaagtt gatacttctt atgaaatgtt aggcactaaa acctctgttc ctttttatgt     2160

atctgccacc gctttggcta aattaggcca tcctgatggt gaatgctcaa ttgctagagg     2220

cgctggtaag gaaggtgtcg ttcaaatgat ttcgaccctt tcctcaatgt cattagatga     2280

aattgccgct gctagaattc caggtgcaac ccaatggttc caattataca ttaatgagga     2340

tagaaatgtc gctaaaggtc tggtcaaaca tgcagaagac ttgggtatga aggctatctt     2400

tataactgtt gatgctcctt ctctaggtaa cagagaaaag gataaaagat taaagtttgt     2460

taatgacacc gatgtcgatt tgggtgattc cgcagatcga aacagtggtg cttcaaaggc     2520

actatcttcg ttcattgatg cttctgtctc ttggaatgac gtcaaagcgg tcaagtcgtg     2580

gactaaattg cctgtcttag ttaaaggtgt tcaaacagtt gaagacgtta ttgaagctta     2640

cgatgctggt tgtcaaggtg ttgttttgtc aaaccacggt ggtaggcaac tagatactgc     2700

tcctcctcca atcgaattat tagctgaaac tgttccaact ttgaagagat tgggtaaatt     2760

aagaccagat tttgaaattt taattgacgg tggtgtcaaa agaggtaccg atattttgaa     2820

agcagtcgca atcggtggcc aagatgtcag agtttcagtt ggtatgggta gacctttctt     2880

atatgccaac tcttgctatg gtgaagcagg tgttagaaaa ttaattcaaa atctaaagga     2940

tgaattagaa atggatatga gattgttggg tgtcactaaa atggaccagc tatcttcgaa     3000

acatgtcgat actaaacgtt tgattggtag agatgcgatc aactatttgt atgataatgt     3060

atacagccca atcgaaaccg ttaaattcaa caatgaagat tgattgttgg aaatatatta     3120

ttcataaagg cgaaaacatt cccttggtat tttattccaa atttatgata catagacgta     3180

ttttttatat ataaagttat attattaatg attcaagaaa aagttcaaat aaactaatgg     3240

atcaaccata acttcgtata atgtatgcta tacgaagtta tagatctgcc gtccaggagt     3300

ccatcggttc ctgtcagatg ggatactctt gacgtggaaa attcaaacag aaaaaaaacc     3360

cccaataatg aaaaataata ctacgttata tccgtggtat cctctatcgt atcgtatcgt     3420

agcgtatcgt accgtaccgt atcacagtat agtctaatat tccgtatctt attgtatcct     3480

atcctattcg atcctattgt atttctgtgc accattttaa tttctattgc tataatgtcc     3540

ttattagttg ccactgtgag gtgaccaatg gacgagggcg agccgttcag aagccgcgaa     3600

gggtgttctt cccatgaatt tcttaaggag ggcggctcag ctccgagagt gaggcgagac     3660

gtctcggtta gcgtatcccc cttcctcggc ttttacaaat gatgcgctct taatagtgtg     3720

tcgttatcct tttggcattg acgggggagg gaaattgatt gagcgcatcc atattttggc     3780

ggactgctga ggacaatggt ggtttttccg ggtggcgtgg gctacaaatg atacgatggt     3840

ttttttcttt tcggagaagg cgtataaaaa ggacacggag aacccattta ttctaataac     3900

agttgagctt ctttaattat ttgttaatat aatattctat tattatatat tttcttccca     3960

ataaaacaaa ataaaacaaa acacagcaaa acacaaaaat tctagacgca cgcgtatgac     4020

tatttcttct gcacatccag agacagaacc aaagtggtgg aaagaggcca cgttctatca     4080

aatttaccca gcaagtttca aagactctaa tgacgatggc tggggtgata tgaagggtat     4140

ttcctccaag ttggagtata tcaaggagct tggtgtcgat gccatttgga tctcaccatt     4200

ctacgactcg ccacaagatg atatgggtta cgatattgcc aactacgaaa aggtctggcc     4260

aacctacggt acgaacgagg actgctttgc cttgatcgaa aagacacata aacttggtat     4320

gaaatttatc accgacttgg tcatcaatca ctgttccagc gaacatgaat ggttcaaaga     4380

gagcagatcc tcgaagacca atccgaagcg tgactggttc ttctggagac ctcctaaggg     4440

ttatgacgcc gaaggcaagc caattcctcc aaataattgg aagtcctatt ttggtggttc     4500

cgcatggacc ttcgatgaaa agacacaaga attctacttg cgtttgtttt gctccactca     4560

acctgatttg aattgggaga atgaagactg tagaaaggca atctacgaaa gtgccgttgg     4620

atactggtta gaccatggtg tagacggctt tagaattgat gtcggaagtt tgtactccaa     4680

agttgtaggt ttaccagatg cccctgttgt tgacaaaaac ccgacttggc aatccagtga     4740

tccatacaca ttgaatggac cacgtattca cgagttccat caagaaatga atcaattcat     4800

cagaaacaga gtgaaggatg gcagggagat tatgacagtt ggtgaaatgc aacatgcttc     4860

cgacgaaact aagagacttt atacgagtgc ttcaagacac gaacttagtg agttatttaa     4920

cttttcccac actgatgtgg ggacttcacc tttgttccgt tacaacttgg tcccatttga     4980

actgaaggat tggaagattg cccttgctga gctgttcagg ttcattaatg gtacagattg     5040

ttggtcaaca atctatctgg aaaatcacga ccaacctcgt tcaattacga gatttggtga     5100

cgattctcct aagaaccgtg ttatttctgg taagttactc tctgtgttgc taagtgcctt     5160

gaccggtact ctatatgtgt atcagggaca agagcttggc caaatcaatt tcaagaactg     5220

gcctgttgaa aagtacgagg atgtcgaaat cagaaacaac tacaatgcaa ttaaagaaga     5280

gcatggggaa aactcagagg agatgaaaaa gtttttagaa gccattgcca ttatctccag     5340

ggaccatgct agaacaccta tgcaatggtc tcgtgaggag ccaaatgctg gtttttctgg     5400

tcctagtgct aaaccatggt tttacttgaa cgactctttc agagaaggca ttaacgtcga     5460

agatgaaatc aaggatccca actcggtttt gaacttctgg aaggaggcct tgaagtttag     5520

aaaggcgcat aaagacatta ctgtgtacgg atacgatttt gagtttattg atttagacaa     5580

taagaagttg tttagcttca caaagaagta caacaataaa acattgtttg cggccttgaa     5640

ctttagctct gatgcgacag atttcaagat tccaaatgat gattcatcgt tcaagttaga     5700

gtttggaaac tatccaaaga aggaggtaga tgcctcttcc agaacattga agccatggga     5760

aggaagaata tatatcagcg aatgacctgc aggtttgcca gcttactatc cttcttgaaa     5820

atatgcactc tatatctttt agttcttaat tgcaacacat agatttgctg tataacgaat     5880

tttatgctat tttttaaatt tggagttcag tgataaaagt gtcacagcga atttcctcac     5940

atgtagggac cgaattgttt acaagttctc tgtaccacca tggagacatc aaaaattgaa     6000

aatctatgga aagatatgga cggtagcaac aagaatatag cacgagccgg cgctagcgag     6060

ctcgtctgat atttgctaaa ttgaaatgaa ccttaccatg ccacatctat agacatcaaa     6120

accattttca atttgtcgat atcttttgca tatcaaagta ataccaagca tgttcaaaaa     6180

gaaaagaaag cataacttta atactctatt cgaaacattc cgatccacaa cacattagtc     6240

tttttaggcc cgttgttcat ctttctatta ctttattcct aactgtattt ttataattcc     6300

gggtttataa aagattaaac taatatagcg cattcttttt gggtacaaac atacataacg     6360

gaggttt                                                               6367


<210>  16
<211>  2147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KBpcr330

<400>  16
gtctataaaa ggcgggtttt gtcttttgcc agttgatgtt gctgagagga cttgtttgcc       60

gtttcttccg atttaacagt atagaatcaa ccactgttaa ttatacacgt tatactaaca      120

caacaaaaac aaaaacaacg acaacaacaa caacaatgaa aaacatcatt tcattagttt      180

ctaagaagaa ggctgcatcc aaaaatgaag ataaaaacat ctctgaatct tcaagagata      240

tcgttaatca acaagaggtt ttcaataccg aagatttcga ggaaggcaaa aaggactctg      300

cattcgagtt agatcacttg gagtttacta ccaactccgc acaattaggc gactctgatg      360

aggacaacga aaacgtcatt aacgaaatga acgcaacaga cgatgcaaac gaagcaaact      420

ctgaagagaa atccatgacc ttgaagcaag cattgttgaa gtatcctaaa gccgcattat      480

ggtctatttt agtctccact actttggtca tggaaggtta cgacactgct ttgttatccg      540

cattatacgc tttaccagtt tttcaacgta agtttggtac attgaatggt aaaggttcct      600

atgagattac atcccaatgg cagattggtc ttaacatgtg cgtcttgtgt ggtgaaatga      660

ttggtttaca aatcaccacc tatatggttg agtttatggg taacagatac actatgatca      720

ccgctttagg tcttttgact gcttacattt tcattttgta ctattgtaag tccttagcca      780

tgattgctgt tggtcaaatt ttgtccgcca tcccttgggg ttgttttcaa tctttggctg      840

ttacctatgc ttctgaagtc tgcccattag cacttagata ctatatgact tcctattcta      900

acatttgctg gttgttcggc caaatcttcg catctggtat catgaaaaac tcacaagaga      960

acttaggcaa ttccgatctt ggttacaaac ttccatttgc tttacagtgg atttggcctg     1020

ccccacttat gattggtatt ttctttgctc cagaatctcc ttggtggctt gttagaaaag     1080

atagagttgc agaagctaga aagtcattat ccagaatttt gtctggtaag ggcgctgaaa     1140

aggatattca agttgatctt accttaaagc agattgaatt aactattgaa aaggaaagat     1200

tattagcttc taagtctggt tcattcttta actgtttcaa gggtgttaat ggtcgtagaa     1260

ccagattagc atgtttaacc tgggttgccc aaaactcctc cggtgcagtt ttgttaggtt     1320

attctactta ctttttcgaa agagctggta tggcaacaga caaggctttc acattctcat     1380

taatccagta ctgtttgggt cttgcaggca ccttatgttc atgggttatt tcaggtagag     1440

tcggtagatg gactatcttg acttatggtc ttgcttttca aatggtctgt ttgttcatta     1500

tcggtggtat gggttttggt tctggttcct ctgcttccaa tggtgctggt ggcttattgt     1560

tggcattatc ctttttctac aatgcaggca tcggtgctgt tgtctattgt attgtcgccg     1620

aaattccttc agcagaattg agaaccaaga ctattgtttt ggctagaatc tgttacaatt     1680

tgatggccgt tatcaatgct attttgaccc catacatgtt gaacgtttct gactggaact     1740

ggggtgctaa gacaggcttg tattggggtg gtttcactgc agttactttg gcttgggtta     1800

ttatcgactt accagaaacc actggtagaa cattctctga aatcaatgaa ttattcaacc     1860

aaggtgttcc agctcgtaag ttcgcatcta ctgtcgtcga tccattcggt aagggtaaga     1920

cccaacatga ttccttggcc gatgaatcca tctctcaatc ttcatccatt aagcaaagag     1980

aattgaatgc agcagataag tgttaaggga tatctagtta gatagctcct cctccaatcg     2040

aattattagc tgaaactgtt ccaactttga agagattggg taaattaaga ccagattttg     2100

aaattttaat tgacggtggt gtcaaaagag gtaccgatat tttgaaa                   2147


<210>  17
<211>  3120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KBpcr329

<400>  17
cacctactgg taatctgtaa tctatattcc cgctgaccct ttataaatga actattgtcg       60

tcaattgcgg tagtgctcca acaaattgta aggaccttct ttaacctttt cgattcaatc      120

catctccaca taaacctagt tgcacacaca gcaatttgag gaaggaatag gagaaggaga      180

agcaatttct aggaaagagc aaggtgtgca acagcatgct ctgaatgata ttttcagcaa      240

tagttcagtt gaagaacctg ttggcgtatc tacatcactt cctacaaaca acaccacgaa      300

ttgcgtccgt ggtgacgcaa ctacgaatgg cattgtcaat gccaatgcca gtgcacatac      360

acgtgcaagt cccaccggtt ccctgcccgg ctatggtaga gacaagaagg acgataccgg      420

catcgacatc aacagtttca acagcaatgc gtttggcgtc gacgcgtcga tggggctgcc      480

gtatttggat ttggacgggc tagatttcga tatggatatg gatatggata tggatatgga      540

gatgaatttg aatttagatt tgggtcttga tttggggttg gaattaaaag gggataacaa      600

tgagggtttt cctgttgatt taaacaatgg acgtgggagg tgattgattt aacctgatcc      660

aaaaggggta tgtctatttt ttagagtgtg tctttgtgtc aaattatggt agaatgtgta      720

aagtagtata aactttcctc tcaaatgacg aggtttaaaa caccccccgg gtgagccgag      780

ccgagaatgg ggcaattgtt caatgtgaaa tagaagtatc gagtgagaaa cttgggtgtt      840

ggccagccaa gggggaagga aaatggcgcg aatgctcagg tgagattgtt ttggaattgg      900

gtgaagcgag gaaatgagcg acccggaggt tgtgacttta gtggcggagg aggacggagg      960

aaaagccaag agggaagtgt atataagggg agcaatttgc caccaggata gaattggatg     1020

agttataatt ctactgtatt tattgtataa tttatttctc cttttatatc aaacacatta     1080

caaaacacac aaaacacaca aacaaacaca atgaaaaata tcatttcatt ggtaagcaag     1140

aagaaggctg cctcaaaaaa tgaggataaa aacatttctg agtcttcaag agatattgta     1200

aaccaacagg aggttttcaa tactgaagat tttgaagaag ggaaaaagga tagtgccttt     1260

gagctagacc acttagagtt caccaccaat tcagcccagt taggagattc tgacgaagat     1320

aacgagaatg tgattaatga gatgaacgct actgatgatg caaatgaagc taacagcgag     1380

gaaaaaagca tgactttgaa gcaggcgttg ctaaaatatc caaaagcagc cctgtggtcc     1440

atattagtgt ctactaccct ggttatggaa ggttatgata ccgcactact gagcgcactg     1500

tatgccctgc cagtttttca gagaaaattc ggtactttga acggggaggg ttcttacgaa     1560

attacttccc aatggcccat tggtttaaac atgtgtgtcc aatgtggtga gatgattggt     1620

ttgcaaatca cgccttattt ggttgaattt atggggaatc gttatacgat gattacagca     1680

cttggtttgt taactgctta tgtctttatc ctctactact gtaaaagttt agctatgatt     1740

gctgtgggac aaattctctc agctatgcca tggggttgtt tccagggttt gactgttact     1800

tatgcttccg aagtttgccc tttagcatta agatattaca tgaccagtta ctccaacatt     1860

tgttggttat ttggtcaaat cttcgcctct ggtattatga aaaactcaca agagaattta     1920

gggaactctg acttgggcta taaattgcca tttgctttac aatggatttg gcctgctcct     1980

ttaatgatcg gtatcttttt cgctcctgag tcgccctggt ggttggtgag aaaggatagg     2040

gtcgctgagg caagaaaatc tttaagcaga attttgagtg gtaaaggcgc cgagaaggac     2100

attcaagttg atcttacttt aaagcagatt gaattgacta ttgaaaaaga aagactttta     2160

gcatctaaat caggatcatt ctttgattgt ttcaagggag ttaatggaag aagaacgaga     2220

cttgcatgtt taacttgggt agctcaaaat actagcggtg cctgtttact tggttactcg     2280

acatattttt ttgaaagagc aggtatggcc accgacaagg cgtttacttt ttctgtaatt     2340

cagtactgtc ttgggttagc gggtacactt tgctcctggg taatatctgg ccgtgttggt     2400

agatggacaa tactgaccta tggtcttgca tttcaaatgg tctgcttatt tattattggt     2460

ggaatgggtt ttggttctgg aagcagcgct agtaatggtg ccggtggttt attgctggct     2520

ttatcattct tttacaatgc tggtatcggt gcagttgttt actgtatcgt tgctgaaatt     2580

ccatcagcgg agttgagaac taagactata gtgctggccc gtatttgcta caatctcatg     2640

gccgttatta acgctatatt aacgccctat atgctaaacg tgagcgattg gaactggggt     2700

gccaaaactg gtctatactg gggtggtttc acagcagtca ctttagcttg ggtcatcatc     2760

gatctgcctg agacaactgg tagaaccttc agtgaaatta atgaactttt caaccaaggg     2820

gttcctgcca gaaaatttgc atctactgtg gttgatccat tcggaaaggg aaaaactcaa     2880

catgattcgc tagctgatga gagtatcagt cagtcctcaa gcataaaaca gcgagaatta     2940

aatgcagctg ataaatgtta agggatatct agttagatag ctcctcctcc aatcgaatta     3000

ttagctgaaa ctgttccaac tttgaagaga ttgggtaaat taagaccaga ttttgaaatt     3060

ttaattgacg gtggtgtcaa aagaggtacc gatattttga aagcagtcgc aatcggtggc     3120


<210>  18
<211>  616
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  18

Met Lys Asn Ile Ile Ser Leu Val Ser Lys Lys Glu Ala Ala Ser Lys 
1               5                   10                  15      


Asn Glu Asp Lys Asn Ile Ser Glu Ser Ser Arg Asp Ile Val Asn Gln 
            20                  25                  30          


Gln Glu Val Phe Asn Thr Glu Asn Phe Glu Glu Gly Lys Lys Asp Ser 
        35                  40                  45              


Ala Phe Glu Leu Asp His Leu Glu Phe Thr Thr Asn Ser Ala Gln Leu 
    50                  55                  60                  


Gly Asp Ser Asp Glu Asp Asn Glu Asn Val Ile Asn Glu Thr Asn Ala 
65                  70                  75                  80  


Thr Asp Asp Ala Asn Glu Ala Asn Ser Glu Glu Lys Ser Met Thr Leu 
                85                  90                  95      


Lys Gln Ala Leu Leu Ile Tyr Pro Lys Ala Ala Leu Trp Ser Ile Leu 
            100                 105                 110         


Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ala Leu Leu Asn 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Val Phe Gln Arg Lys Phe Gly Thr Leu Asn 
    130                 135                 140                 


Gly Glu Gly Ser Tyr Glu Ile Thr Ser Gln Trp Gln Ile Gly Leu Asn 
145                 150                 155                 160 


Met Cys Val Gln Cys Gly Glu Met Ile Gly Leu Gln Ile Thr Pro Tyr 
                165                 170                 175     


Met Val Glu Phe Met Gly Asn Arg Tyr Thr Met Ile Thr Ala Leu Gly 
            180                 185                 190         


Leu Leu Thr Ala Tyr Val Phe Ile Leu Tyr Tyr Cys Lys Ser Leu Ala 
        195                 200                 205             


Met Ile Ala Val Gly Gln Val Leu Ser Ala Met Pro Trp Gly Cys Phe 
    210                 215                 220                 


Gln Gly Leu Thr Val Thr Tyr Ala Ser Glu Val Cys Pro Leu Ala Leu 
225                 230                 235                 240 


Arg Tyr Tyr Met Thr Ser Tyr Ser Asn Ile Cys Trp Leu Phe Gly Gln 
                245                 250                 255     


Ile Phe Ala Ser Gly Ile Met Lys Asn Ser Gln Glu Asn Leu Gly Asn 
            260                 265                 270         


Ser Asp Leu Gly Tyr Lys Leu Pro Phe Ala Leu Gln Trp Ile Trp Pro 
        275                 280                 285             


Ala Pro Leu Met Ile Gly Ile Phe Phe Ala Pro Glu Ser Pro Trp Trp 
    290                 295                 300                 


Leu Val Arg Lys Asp Arg Val Ala Glu Ala Arg Lys Ser Leu Ser Arg 
305                 310                 315                 320 


Ile Leu Ser Gly Lys Gly Ala Glu Lys Asp Ile Gln Val Asp Leu Thr 
                325                 330                 335     


Leu Lys Gln Ile Glu Leu Thr Ile Glu Lys Glu Arg Leu Leu Ala Ser 
            340                 345                 350         


Lys Ser Gly Ser Phe Phe Asp Cys Phe Lys Gly Val Asn Gly Arg Arg 
        355                 360                 365             


Thr Arg Leu Ala Cys Leu Thr Trp Val Ala Gln Asn Thr Ser Gly Ala 
    370                 375                 380                 


Cys Leu Leu Gly Tyr Ser Thr Tyr Phe Phe Glu Arg Ala Gly Met Ala 
385                 390                 395                 400 


Thr Asp Lys Ala Phe Thr Phe Ser Val Ile Gln Tyr Cys Leu Gly Leu 
                405                 410                 415     


Ala Gly Thr Leu Cys Ser Trp Val Ile Ser Gly Arg Val Gly Arg Trp 
            420                 425                 430         


Thr Ile Leu Thr Tyr Gly Leu Ala Phe Gln Met Val Cys Leu Phe Ile 
        435                 440                 445             


Ile Gly Gly Met Gly Phe Gly Ser Gly Ser Gly Ala Ser Asn Gly Ala 
    450                 455                 460                 


Gly Gly Leu Leu Leu Ala Leu Ser Phe Phe Tyr Asn Ala Gly Ile Gly 
465                 470                 475                 480 


Ala Val Val Tyr Cys Ile Val Thr Glu Ile Pro Ser Ala Glu Leu Arg 
                485                 490                 495     


Thr Lys Thr Ile Val Leu Ala Arg Ile Cys Tyr Asn Ile Met Ala Val 
            500                 505                 510         


Ile Asn Ala Ile Leu Thr Pro Tyr Met Leu Asn Val Ser Asp Trp Asn 
        515                 520                 525             


Trp Gly Ala Lys Thr Gly Leu Tyr Trp Gly Gly Phe Thr Ala Val Thr 
    530                 535                 540                 


Leu Ala Trp Val Ile Ile Asp Leu Pro Glu Thr Ser Gly Arg Ala Phe 
545                 550                 555                 560 


Ser Glu Ile Asn Glu Leu Phe Asn Gln Gly Val Pro Ala Arg Lys Phe 
                565                 570                 575     


Ala Ser Thr Val Val Asp Pro Phe Gly Lys Gly Lys Thr Arg His Asp 
            580                 585                 590         


Ser Leu Ala Asp Glu Ser Ile Ser Gln Ser Ser Ser Ile Lys Gln Arg 
        595                 600                 605             


Glu Leu Asn Ala Ala Asp Lys Cys 
    610                 615     


<210>  19
<211>  3310
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCM507 integration fragment

<400>  19
cccgccatga tggttgtatt ctaccaatga gacatggccg ctgatcctgt tgtgtgggtc       60

atgggacatc acctcttggg gaggattctc ctataattgg caccgtgtat gcctcaacca      120

ctaacttcca ccctataact gaatatatta cataagcaaa tctacttttt gtttgtgttg      180

atcgccatcg ttgaaattcg cgcaacttct ggtggctcaa cgctgctgtt ctatcggtat      240

cctaagagat gtctttgccc tgagtctagg gtaaactatc caccttcgtt gctgtttgac      300

tagacagcta ctaactttac ggtagtaaat gaataacggc tcgctctcat gatcacttct      360

ctacatcacc ctaacaagtg tattattttt tttcaggtgg gtgttgctgt tggtgctagc      420

cttagtgccc tcgttaatag ttgaacaaac actggcattt ggagtataat gaaaagggat      480

cactaccccc cgcttcctgt tccgcttctc ccttccggaa aaaccaccca ccctttcttt      540

tcccccacta atgtatgaat ttttccgttc ccaggggaat ggcccacttg gttctctgtt      600

aacccacaca attttgacgc atcccacaca cctttttttt tttctacccc acactttccc      660

ttgaaaaatc tccaatttga actggcaatt ttcacccccc accacttgca ttcattagtg      720

agtcaatcca tcccgcggtc ggagattcgg aatccaccta ctggtaatct gtaatctata      780

ttcccgctga cccttgtcga cttgctgcaa cggcaacatc aatgtccacg tttacacacc      840

tacatttata tctatattta tatttatatt tatttattta tgctacttag cttctatagt      900

tagttaatgc actcacgata ttcaaaattg acacccttca actactccct actattgtct      960

actactgtct actactcctc tttactatag ctgctcccaa taggctccac caataggctc     1020

tgtcaataca ttttgcgccg ccacctttca ggttgtgtca ctcctgaagg accatattgg     1080

gtaatcgtgc aatttctgga agagagtccg cgagaagtga ggcccccact gtaaatcctc     1140

gagggggcat ggagtatggg gcatggagga tggaggatgg ggggggggag aaaataggta     1200

gcgaaaggac ccgctatcac cccacccgga gaactcgttg ccgggaagtc atatttcgac     1260

actccgggga gtctataaaa ggcgggtttc gtcttttgcc agttgatgtt gctgagagga     1320

cttgtttgcc gtttcttccg atttaacagt atagaatcaa ccactgttaa ttatacacgt     1380

tatactaaca caacaaaaac aaaaacaacg acaacaacaa caacaatgtc cgcccaacac     1440

gttgaggaca ttgacaaacc aggtgttgtt atcgaagtta acccattgaa caagaacatg     1500

actgacgact ctatggctca cgaagcccaa gattttatgg acaaattttt ggacatgtct     1560

gaaaacgcta aggacaacga tagaaaggaa aagtacatgc ctttaaagga aggtttaaag     1620

accttcccaa aggctgccat gtggtccgtt attttgtcta ctgccttaat catggaaggt     1680

tacgacacca atttgttaaa ttctttgtac gccttccctg atttcgctaa gaagttcggt     1740

gaatactctg aatccgacgg ttcctaccaa attccagcta aatggcaaac ttctttatcc     1800

atgtgtgtta acgtcggtga aatcattggt ttgttcatcg ctggtatcat cgctgataga     1860

attggttaca gaaaaacttt gatcggtgcc ttgatgttga ctaccggttt catcttcatt     1920

gttttctttg ccgttaatgt tgaaatgttg ttggctggtg aattattgtt gggtttacca     1980

tggggtgcct tccaaacttt gactgtttct tacgcttctg aagtttgtcc aaccaccttg     2040

agagtctact tgaccactta tgttaacgtc tgttgggttt tcggtcaatt gatttcctct     2100

ggtatcttga gaggtttggt ttcctccgac attgaagacg tctaccgtat tccttttgcc     2160

gtccaatggg tttggccaat cccaattgcc attggtattt acttggctcc agaatctcca     2220

tggtggttgg ctagaaaaaa tagaatccaa gaagctaagc actccattaa gagattattg     2280

actgtcaacg aacacttgcc tgacaaggaa atcttggctg aggctatggt tcaaaagatc     2340

caaatgactt tgaaggaaga agctttaact aacaacggtg aatctttttt ggattgtttt     2400

aagggtcaag acttgagaag aaccagaatt gctgctattg tttgggtttc ccaaaactta     2460

actggttcct ccttgatggg ttactctacc tacttctatc aacaagctgg tttgggtcaa     2520

aacatgtcct tcactttctc tatcattcaa tactgtttcg gtatcgttgg tactttgggt     2580

tcctggttat tgtctcaaaa ggctggtaga ttcactatct acttttacgg tttgtgttct     2640

ttgttttgta tcttattcgt cgtcggttgt ttgggtatta atccaaccga atcctcttct     2700

tggggtgtcg gttctttgtt gttagtttat accttcgttt acgatttaac tatcggtcct     2760

ttgtgctact gtattgttgc tgaaattcca tccactaaat tgagaactaa aaccattatt     2820

attgctagaa acgcttacaa cattgctggt attgttgttg ctattatcac tccatacatg     2880

ttgaatccaa ccgcctggaa ctggaaggcc aagaccggtt ttttctggtc tggtttcgcc     2940

tttttcgctg ccatttggtg ttggttcgat ttgccagaaa ctaagggtaa gaccttcgcc     3000

gaattggatc aattgttcga aaacaaggtc aaggccagac aattcaagaa gactgaagtt     3060

gaagttttta atactgacga attgattgaa agattaggtg aagacggtat taaagatttg     3120

gtcgttactg acgcttctaa agatgaattt tccgaaaaag tttaattgtt ggaaatatat     3180

tattcataaa ggcgaaaaca ttcccttggt attttattcc aaatttatga tacatagacg     3240

tattttttat atataaagtt atattattaa tgattcaaga aaaagttcaa ataaactaat     3300

ggatcgggcc                                                            3310


<210>  20
<211>  579
<212>  PRT
<213>  Debaryomyces hansenii

<400>  20

Met Ser Ala Gln His Val Glu Asp Ile Asp Lys Pro Gly Val Val Ile 
1               5                   10                  15      


Glu Val Asn Pro Leu Asn Lys Asn Met Thr Asp Asp Ser Met Ala His 
            20                  25                  30          


Glu Ala Gln Asp Phe Met Asp Lys Phe Leu Asp Met Ser Glu Asn Ala 
        35                  40                  45              


Lys Asp Asn Asp Arg Lys Glu Lys Tyr Met Pro Leu Lys Glu Gly Leu 
    50                  55                  60                  


Lys Thr Phe Pro Lys Ala Ala Met Trp Ser Val Ile Leu Ser Thr Ala 
65                  70                  75                  80  


Leu Ile Met Glu Gly Tyr Asp Thr Asn Leu Leu Asn Ser Leu Tyr Ala 
                85                  90                  95      


Phe Pro Asp Phe Ala Lys Lys Phe Gly Glu Tyr Ser Glu Ser Asp Gly 
            100                 105                 110         


Ser Tyr Gln Ile Pro Ala Lys Trp Gln Thr Ser Leu Ser Met Cys Val 
        115                 120                 125             


Asn Val Gly Glu Ile Ile Gly Leu Phe Ile Ala Gly Ile Ile Ala Asp 
    130                 135                 140                 


Arg Ile Gly Tyr Arg Lys Thr Leu Ile Gly Ala Leu Met Leu Thr Thr 
145                 150                 155                 160 


Gly Phe Ile Phe Ile Val Phe Phe Ala Val Asn Val Glu Met Leu Leu 
                165                 170                 175     


Ala Gly Glu Leu Leu Leu Gly Leu Pro Trp Gly Ala Phe Gln Thr Leu 
            180                 185                 190         


Thr Val Ser Tyr Ala Ser Glu Val Cys Pro Thr Thr Leu Arg Val Tyr 
        195                 200                 205             


Leu Thr Thr Tyr Val Asn Val Cys Trp Val Phe Gly Gln Leu Ile Ser 
    210                 215                 220                 


Ser Gly Ile Leu Arg Gly Leu Val Ser Ser Asp Ile Glu Asp Val Tyr 
225                 230                 235                 240 


Arg Ile Pro Phe Ala Val Gln Trp Val Trp Pro Ile Pro Ile Ala Ile 
                245                 250                 255     


Gly Ile Tyr Leu Ala Pro Glu Ser Pro Trp Trp Leu Ala Arg Lys Asn 
            260                 265                 270         


Arg Ile Gln Glu Ala Lys His Ser Ile Lys Arg Leu Leu Thr Val Asn 
        275                 280                 285             


Glu His Leu Pro Asp Lys Glu Ile Leu Ala Glu Ala Met Val Gln Lys 
    290                 295                 300                 


Ile Gln Met Thr Leu Lys Glu Glu Ala Leu Thr Asn Asn Gly Glu Ser 
305                 310                 315                 320 


Phe Leu Asp Cys Phe Lys Gly Gln Asp Leu Arg Arg Thr Arg Ile Ala 
                325                 330                 335     


Ala Ile Val Trp Val Ser Gln Asn Leu Thr Gly Ser Ser Leu Met Gly 
            340                 345                 350         


Tyr Ser Thr Tyr Phe Tyr Gln Gln Ala Gly Leu Gly Gln Asn Met Ser 
        355                 360                 365             


Phe Thr Phe Ser Ile Ile Gln Tyr Cys Phe Gly Ile Val Gly Thr Leu 
    370                 375                 380                 


Gly Ser Trp Leu Leu Ser Gln Lys Ala Gly Arg Phe Thr Ile Tyr Phe 
385                 390                 395                 400 


Tyr Gly Leu Cys Ser Leu Phe Cys Ile Leu Phe Val Val Gly Cys Leu 
                405                 410                 415     


Gly Ile Asn Pro Thr Glu Ser Ser Ser Trp Gly Val Gly Ser Leu Leu 
            420                 425                 430         


Leu Val Tyr Thr Phe Val Tyr Asp Leu Thr Ile Gly Pro Leu Cys Tyr 
        435                 440                 445             


Cys Ile Val Ala Glu Ile Pro Ser Thr Lys Leu Arg Thr Lys Thr Ile 
    450                 455                 460                 


Ile Ile Ala Arg Asn Ala Tyr Asn Ile Ala Gly Ile Val Val Ala Ile 
465                 470                 475                 480 


Ile Thr Pro Tyr Met Leu Asn Pro Thr Ala Trp Asn Trp Lys Ala Lys 
                485                 490                 495     


Thr Gly Phe Phe Trp Ser Gly Phe Ala Phe Phe Ala Ala Ile Trp Cys 
            500                 505                 510         


Trp Phe Asp Leu Pro Glu Thr Lys Gly Lys Thr Phe Ala Glu Leu Asp 
        515                 520                 525             


Gln Leu Phe Glu Asn Lys Val Lys Ala Arg Gln Phe Lys Lys Thr Glu 
    530                 535                 540                 


Val Glu Val Phe Asn Thr Asp Glu Leu Ile Glu Arg Leu Gly Glu Asp 
545                 550                 555                 560 


Gly Ile Lys Asp Leu Val Val Thr Asp Ala Ser Lys Asp Glu Phe Ser 
                565                 570                 575     


Glu Lys Val 
            


<210>  21
<211>  3454
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCM510 integration fragment

<400>  21
cccgccatga tggttgtatt ctaccaatga gacatggccg ctgatcctgt tgtgtgggtc       60

atgggacatc acctcttggg gaggattctc ctataattgg caccgtgtat gcctcaacca      120

ctaacttcca ccctataact gaatatatta cataagcaaa tctacttttt gtttgtgttg      180

atcgccatcg ttgaaattcg cgcaacttct ggtggctcaa cgctgctgtt ctatcggtat      240

cctaagagat gtctttgccc tgagtctagg gtaaactatc caccttcgtt gctgtttgac      300

tagacagcta ctaactttac ggtagtaaat gaataacggc tcgctctcat gatcacttct      360

ctacatcacc ctaacaagtg tattattttt tttcaggtgg gtgttgctgt tggtgctagc      420

cttagtgccc tcgttaatag ttgaacaaac actggcattt ggagtataat gaaaagggat      480

cactaccccc cgcttcctgt tccgcttctc ccttccggaa aaaccaccca ccctttcttt      540

tcccccacta atgtatgaat ttttccgttc ccaggggaat ggcccacttg gttctctgtt      600

aacccacaca attttgacgc atcccacaca cctttttttt tttctacccc acactttccc      660

ttgaaaaatc tccaatttga actggcaatt ttcacccccc accacttgca ttcattagtg      720

agtcaatcca tcccgcggtc ggagattcgg aatccaccta ctggtaatct gtaatctata      780

ttcccgctga cccttgtcga cttgctgcaa cggcaacatc aatgtccacg tttacacacc      840

tacatttata tctatattta tatttatatt tatttattta tgctacttag cttctatagt      900

tagttaatgc actcacgata ttcaaaattg acacccttca actactccct actattgtct      960

actactgtct actactcctc tttactatag ctgctcccaa taggctccac caataggctc     1020

tgtcaataca ttttgcgccg ccacctttca ggttgtgtca ctcctgaagg accatattgg     1080

gtaatcgtgc aatttctgga agagagtccg cgagaagtga ggcccccact gtaaatcctc     1140

gagggggcat ggagtatggg gcatggagga tggaggatgg ggggggggag aaaataggta     1200

gcgaaaggac ccgctatcac cccacccgga gaactcgttg ccgggaagtc atatttcgac     1260

actccgggga gtctataaaa ggcgggtttc gtcttttgcc agttgatgtt gctgagagga     1320

cttgtttgcc gtttcttccg atttaacagt atagaatcaa ccactgttaa ttatacacgt     1380

tatactaaca caacaaaaac aaaaacaacg acaacaacaa caacaatgaa gtccttagcc     1440

caaattgtca acagaaagaa taagaagaat ttggaagaac cagatattgt tagagctggt     1500

gtttcttctg gttccagatt atctttgaac agatctaact ttgaattaga agataccgat     1560

aagaagaagg cttccgatgc tttggaattg gaccacttgg agttcacttc tgacgtcgcc     1620

caaatcaacg aagaagaaga ccaaaacgac cacgctttgg gtgtcattaa cgccgctgat     1680

gacgctcaag aagctaatga agaggaaaaa aagatgactt tggtccaagc tttgaaggct     1740

tacccaaaag ctgctgcttg gtccgtcttg gtctctacca ccttggttat ggaaggttac     1800

gatacctcct tattgaacgc tttgttcgct ttgccagtct tccaagaaaa attcggttcc     1860

atttctaaga ccggtgaata cgaaatctct tctcaatggc aaatcggttt gaatatgtgt     1920

atttttgtcg gtgaaattat cggtttacaa atgaccggtt tcttggttga atggttcggt     1980

aacagatgga ccatgatcgg tgctttaggt ttgttgactg cttacatctt cttgttgtac     2040

ttctgtaaat ctttggctat gatcgctgtt gctcaaatct tgtccgctat gccatggggt     2100

tgtttccaat ctttggctgt cacctacgct tctgaagtct gtccattaac cttgagatac     2160

tatttaacca cttattctaa catgtgttgg ttgttcggtc aaattttctc cgctggtatt     2220

atgaagaact ctcaatctaa cttgggtaac tctgatttgg gttacaagat gccattcgct     2280

ttgcaatgga tctggccagc tccattggct ttgggtattt acttggctcc agaatcccca     2340

tggtacttgg ttagaaagtc caagttcgct gaagctaaga agtctttgaa cagaatcttg     2400

tctggttccg gtccacaaaa ggaaattcaa gttgatttga atttgaagca aattgaatta     2460

accatcgaaa aggaacgtaa gttgaaacaa aagaagggtt ccttctggga ctgcttcaag     2520

ggtgttgatg gtcgtagaac cagaatcacc tgtttgacct gggtctccca aaacacttcc     2580

ggttctgctt tgttgggtta ctccacctac ttcttcgaaa gagccggtat ggacacctct     2640

aacgctttca ctttctccat tatttcttac ttgttgggtt tggttggtac tatgacctcc     2700

tggatcattt ctggtagatt aggtagatgg caaatcttgg ctggtggttt gtgtttccaa     2760

atgttggtct tgtttgtcat cggtggttta ggtttctccg actccccagg tgcttctaac     2820

ggtgctggtg gtttgttgtt agccttgtct tttttctcca acgtcggtat tggttctgtc     2880

tgttactgta ttgtcgccga aatgccatct gctgaattga gaactcaaac tattgttttg     2940

gctagaaact gttacaactt gatggctatt gtcaacgcca tcttgactcc atatatgttg     3000

aacaccggtg attggaattg gggtgccaaa actggtttgt attggggtgg tatgactgcc     3060

ttgaccttgg cctgggtcat catcgacttg ccagaaaccg ctggtagaac cttctctgag     3120

attaacgaat tattcgcccg tggtgtccca gctagaaagt tcaagtccac tgttgttgac     3180

ccattcgcta aaggtagaat cgccgacgac attgctgaag atgacttgga cgccgaagtt     3240

acttctgttt tcagagaaga cgacgttgaa ttgggttctg cctgtgatcc aggtaagact     3300

tctttgtaat tgttggaaat atattattca taaaggcgaa aacattccct tggtatttta     3360

ttccaaattt atgatacata gacgtatttt ttatatataa agttatatta ttaatgattc     3420

aagaaaaagt tcaaataaac taatggatcg ggcc                                 3454


<210>  22
<211>  627
<212>  PRT
<213>  Torulaspora delbrueckii

<400>  22

Met Lys Ser Leu Ala Gln Ile Val Asn Arg Lys Asn Lys Lys Asn Leu 
1               5                   10                  15      


Glu Glu Pro Asp Ile Val Arg Ala Gly Val Ser Ser Gly Ser Arg Leu 
            20                  25                  30          


Ser Leu Asn Arg Ser Asn Phe Glu Leu Glu Asp Thr Asp Lys Lys Lys 
        35                  40                  45              


Ala Ser Asp Ala Leu Glu Leu Asp His Leu Glu Phe Thr Ser Asp Val 
    50                  55                  60                  


Ala Gln Ile Asn Glu Glu Glu Asp Gln Asn Asp His Ala Leu Gly Val 
65                  70                  75                  80  


Ile Asn Ala Ala Asp Asp Ala Gln Glu Ala Asn Glu Glu Glu Lys Lys 
                85                  90                  95      


Met Thr Leu Val Gln Ala Leu Lys Ala Tyr Pro Lys Ala Ala Ala Trp 
            100                 105                 110         


Ser Val Leu Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ser 
        115                 120                 125             


Leu Leu Asn Ala Leu Phe Ala Leu Pro Val Phe Gln Glu Lys Phe Gly 
    130                 135                 140                 


Ser Ile Ser Lys Thr Gly Glu Tyr Glu Ile Ser Ser Gln Trp Gln Ile 
145                 150                 155                 160 


Gly Leu Asn Met Cys Ile Phe Val Gly Glu Ile Ile Gly Leu Gln Met 
                165                 170                 175     


Thr Gly Phe Leu Val Glu Trp Phe Gly Asn Arg Trp Thr Met Ile Gly 
            180                 185                 190         


Ala Leu Gly Leu Leu Thr Ala Tyr Ile Phe Leu Leu Tyr Phe Cys Lys 
        195                 200                 205             


Ser Leu Ala Met Ile Ala Val Ala Gln Ile Leu Ser Ala Met Pro Trp 
    210                 215                 220                 


Gly Cys Phe Gln Ser Leu Ala Val Thr Tyr Ala Ser Glu Val Cys Pro 
225                 230                 235                 240 


Leu Thr Leu Arg Tyr Tyr Leu Thr Thr Tyr Ser Asn Met Cys Trp Leu 
                245                 250                 255     


Phe Gly Gln Ile Phe Ser Ala Gly Ile Met Lys Asn Ser Gln Ser Asn 
            260                 265                 270         


Leu Gly Asn Ser Asp Leu Gly Tyr Lys Met Pro Phe Ala Leu Gln Trp 
        275                 280                 285             


Ile Trp Pro Ala Pro Leu Ala Leu Gly Ile Tyr Leu Ala Pro Glu Ser 
    290                 295                 300                 


Pro Trp Tyr Leu Val Arg Lys Ser Lys Phe Ala Glu Ala Lys Lys Ser 
305                 310                 315                 320 


Leu Asn Arg Ile Leu Ser Gly Ser Gly Pro Gln Lys Glu Ile Gln Val 
                325                 330                 335     


Asp Leu Asn Leu Lys Gln Ile Glu Leu Thr Ile Glu Lys Glu Arg Lys 
            340                 345                 350         


Leu Lys Gln Lys Lys Gly Ser Phe Trp Asp Cys Phe Lys Gly Val Asp 
        355                 360                 365             


Gly Arg Arg Thr Arg Ile Thr Cys Leu Thr Trp Val Ser Gln Asn Thr 
    370                 375                 380                 


Ser Gly Ser Ala Leu Leu Gly Tyr Ser Thr Tyr Phe Phe Glu Arg Ala 
385                 390                 395                 400 


Gly Met Asp Thr Ser Asn Ala Phe Thr Phe Ser Ile Ile Ser Tyr Leu 
                405                 410                 415     


Leu Gly Leu Val Gly Thr Met Thr Ser Trp Ile Ile Ser Gly Arg Leu 
            420                 425                 430         


Gly Arg Trp Gln Ile Leu Ala Gly Gly Leu Cys Phe Gln Met Leu Val 
        435                 440                 445             


Leu Phe Val Ile Gly Gly Leu Gly Phe Ser Asp Ser Pro Gly Ala Ser 
    450                 455                 460                 


Asn Gly Ala Gly Gly Leu Leu Leu Ala Leu Ser Phe Phe Ser Asn Val 
465                 470                 475                 480 


Gly Ile Gly Ser Val Cys Tyr Cys Ile Val Ala Glu Met Pro Ser Ala 
                485                 490                 495     


Glu Leu Arg Thr Gln Thr Ile Val Leu Ala Arg Asn Cys Tyr Asn Leu 
            500                 505                 510         


Met Ala Ile Val Asn Ala Ile Leu Thr Pro Tyr Met Leu Asn Thr Gly 
        515                 520                 525             


Asp Trp Asn Trp Gly Ala Lys Thr Gly Leu Tyr Trp Gly Gly Met Thr 
    530                 535                 540                 


Ala Leu Thr Leu Ala Trp Val Ile Ile Asp Leu Pro Glu Thr Ala Gly 
545                 550                 555                 560 


Arg Thr Phe Ser Glu Ile Asn Glu Leu Phe Ala Arg Gly Val Pro Ala 
                565                 570                 575     


Arg Lys Phe Lys Ser Thr Val Val Asp Pro Phe Ala Lys Gly Arg Ile 
            580                 585                 590         


Ala Asp Asp Ile Ala Glu Asp Asp Leu Asp Ala Glu Val Thr Ser Val 
        595                 600                 605             


Phe Arg Glu Asp Asp Val Glu Leu Gly Ser Ala Cys Asp Pro Gly Lys 
    610                 615                 620                 


Thr Ser Leu 
625         


<210>  23
<211>  3937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pKB208 integration fragment


<220>
<221>  misc_feature
<222>  (842)..(842)
<223>  n is a, c, g, or t

<400>  23
aaaccataat gcgtgacacc gccatgatgg ttgtattcta ccaatgagac atggccgctg       60

atcctgttgt gtgggtcatg ggacatcacc tcttgggggg gattctccta taattggcac      120

cgtgtatgcc tcaaccacta acttccaccc tataactgaa tatattacat aagcaaatct      180

actttttgtt tgtgttgatc gccatcgttg aaattcgcgc aacttctggt ggctcaacgc      240

tgctgttcta tcggtatcct aagagatgtc tttgccctga gtctagggta aactatccac      300

cttcgttgct gtttgactag acagctacta actttacggt agtaaatgaa taacggctcg      360

ctctcatgat cacttctcta catcacccta acaagtgtat tatttttttt tcaggtgggt      420

gttgctgttg gtgctagcat atggataact tcgtataatg tatgctatac gaagttatgc      480

tgcaacggca acatcaatgt ccacgtttac acacctacat ttatatctat atttatattt      540

atatttattt atttatgcta cttagcttct atagttagtt aatgcactca cgatattcaa      600

aattgacacc cttcaactac tccctactat tgtctactac tgtctactac tcctctttac      660

tatagctgct cccaataggc tccaccaata ggctctgtca atacattttg cgccgccacc      720

tttcaggttg tgtcactcct gaaggaccat attgggtaat cgtgcaattt ctggaagaga      780

gtgccgcgag aagtgaggcc cccactgtaa atcctcgagg gggcatggag tatggggcat      840

gnaggatgga ggatgggggg ggggggggaa aataggtagc gaaaggaccc gctatcaccc      900

cacccggaga actcgttgcc gggaagtcat atttcgacac tccggggagt ctataaaagg      960

cgggttttgt cttttgccag ttgatgttgc tgagaggact tgtttgccgt ttcttccgat     1020

ttaacagtat agaatcaacc actgttaatt atacacgtta tactaacaca acaaaaacaa     1080

aaacaacgac aacaacaaca acaatgtttg ctttctactt tctcaccgca tgcaccactt     1140

tgaagggtgt tttcggagtt tctccgagtt acaatggtct tggtctcacc ccacagatgg     1200

gttgggacag ctggaatacg tttgcctgcg atgtcagtga acagctactt ctagacactg     1260

ctgatagaat ttctgacttg gggctaaagg atatgggtta caagtatgtc atcctagatg     1320

actgttggtc tagcggcagg gattccgacg gtttcctcgt tgcagacaag cacaaatttc     1380

ccaacggtat gggccatgtt gcagaccacc tgcataataa cagctttctt ttcggtatgt     1440

attcgtctgc tggtgagtac acctgtgctg ggtaccctgg gtctctgggg cgtgaggaag     1500

aagatgctca attctttgca aataaccgcg ttgactactt gaagtatgat aattgttaca     1560

ataaaggtca atttggtaca ccagacgttt cttaccaccg ttacaaggcc atgtcagatg     1620

ctttgaataa aactggtagg cctattttct attctctatg taactggggt caggatttga     1680

cattttactg gggctctggt atcgccaatt cttggagaat gagcggagat attactgctg     1740

agttcacccg tccagatagc agatgtccct gtgacggtga cgaatatgat tgcaagtacg     1800

ccggtttcca ttgttctatt atgaatattc ttaacaaggc agctccaatg gggcaaaatg     1860

caggtgttgg tggttggaac gatctggaca atctagaggt cggagtcggt aatttgactg     1920

acgatgagga aaaggcccat ttctctatgt gggcaatggt aaagtcccca cttatcattg     1980

gtgccgacgt gaatcactta aaggcatctt cgtactcgat ctacagtcaa gcctctgtca     2040

tcgcaattaa tcaagatcca aagggtattc cagccacaag agtctggaga tattatgttt     2100

cagacaccga tgaatatgga caaggtgaaa ttcaaatgtg gagtggtccg cttgacaatg     2160

gtgaccaagt ggttgcttta ttgaatggag gaagcgtagc aagaccaatg aacacgacct     2220

tggaagagat tttctttgac agcaatttgg gttcaaagga actgacatcg acttgggata     2280

tttacgactt atgggccaac agagttgaca actctacggc gtctgctatc cttgaacaga     2340

ataaggcagc caccggtatt ctctacaatg ctacagagca gtcttataaa gacggtttgt     2400

ctaagaatga tacaagactg tttggccaga aaattggtag tctttctcca aatgctatac     2460

ttaacacaac tgttccagct catggtatcg ccttctatag gttgagaccc tcggcttaag     2520

ctcaatgttg agcaaagcag gacgagaaaa aaaaaaataa tgattgttaa gaagttcatg     2580

aaaaaaaaaa ggaaaaatac tcaaatactt ataacagagt gattaaataa taaacggcag     2640

tataccctat caggtattga gatagtttta tttttgtagg tatataatct gaagcctttg     2700

aactattttc tcgtatatat catggagtat acattgcatt agcaacattg catactagtt     2760

cataacttcg tataatgtat gctatacgaa gttattaatt aaagcaattt gaggaaggaa     2820

taggagaagg agaagcaatt tctaggaaag agcaaggtgt gcaacagcat gctctgaatg     2880

atattttcag caatagttca gttgaagaac ctgttggcgt atctacatca cttcctacaa     2940

acaacaccac gaattgcgtc cgtggtgacg caactacgaa tggcattgtc aatgccaatg     3000

ccagtgcaca tacacgtgca agtcccaccg gttccctgcc cggctatggt agagacaaga     3060

aggacgatac cggcatcgac atcaacagtt tcaacagcaa tgcgtttggc gtcgacgcgt     3120

cgatggggct gccgtatttg gatttggacg ggctagattt cgatatggat atggatatgg     3180

atatggatat ggagatgaat ttgaatttag atttgggtct tgatttgggg ttggaattaa     3240

aaggggataa caatgagggt tttcctgttg atttaaacaa tggacgtggg aggtgattga     3300

tttaacctga tccaaaaggg gtatgtctat tttttagagt gtgtctttgt gtcaaattat     3360

ggtagaatgt gtaaagtagt ataaactttc ctctcaaatg acgaggttta aaacaccccc     3420

cgggtgagcc gagccgagaa tggggcaatt gttcaatgtg aaatagaagt atcgagtgag     3480

aaacttgggt gttggccagc caagggggaa ggaaaatggc gcgaatgctc aggtgagatt     3540

gttttggaat tgggtgaagc gaggaaatga gcgacccgga ggttgtgact ttagtggcgg     3600

aggaggacgg aggaaaagcc aagagggaag tgtatataag gggagcaatt tgccaccagg     3660

atagaattgg atgagttata attctactgt atttattgta taatttattt ctccttttat     3720

atcaaacaca ttacaaaaca cacaaaacac acaaacaaac acaatgaaaa atatcatttc     3780

attggtaagc aagaagaagg ctgcctcaaa aaatgaggat aaaaacattt ctgagtcttc     3840

aagagatatt gtaaaccaac aggaggtttt caatactgaa gattttgaag aagggaaaaa     3900

ggatagtgcc tttgagctag accacttaga gttcacc                              3937


<210>  24
<211>  2910
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pKB209 integration fragment

<400>  24
ggtaagcaag aagaaggctg cctcaaaaaa tgaggataaa aacatttctg agtcttcaag       60

agatattgta aaccaacagg aggttttcaa tactgaagat tttgaagaag ggaaaaagga      120

tagtgccttt gagctagacc acttagagtt caccaccaat tcagcccagt taggagattc      180

tgacgaagat aacgagaatg tgattaatga gatgaacgct actgatgatg caaatgaagc      240

taacagcgag gaaaaaagca tgactttgaa gcaggcgttg ctaaaatatc caaaagcagc      300

cctgtggtcc atattagtgt ctactaccct ggttatggaa ggttatgata ccgcactact      360

gagcgcactg tatgccctgc cagtttttca gagaaaattc ggtactttga acggggaggg      420

ttcttacgaa attacttccc aatggcccat tggtttaaac atgtgtgtcc aatgtggtga      480

gatgattggt ttgcaaatca cgccttattt ggttgaattt atggggaatc gttatacgat      540

gattacagca cttggtttgt taactgctta tgtctttatc ctctactact gtaaaagttt      600

agctatgatt gctgtgggac aaattctctc agctatgcca tggggttgtt tccagggttt      660

gactgttact tatgcttccg aagtttgccc tttagcatta agatattaca tgaccagtta      720

ctccaacatt tgttggttat ttggtcaaat cttcgcctct ggtattatga aaaactcaca      780

agagaattta gggaactctg acttgggcta taaattgcca tttgctttac aatggatttg      840

gcctgctcct ttaatgatcg gtatcttttt cgctcctgag tcgccctggt ggttggtgag      900

aaaggatagg gtcgctgagg caagaaaatc tttaagcaga attttgagtg gtaaaggcgc      960

cgagaaggac attcaagttg atcttacttt aaagcagatt gaattgacta ttgaaaaaga     1020

aagactttta gcatctaaat caggatcatt ctttgattgt ttcaagggag ttaatggaag     1080

aagaacgaga cttgcatgtt taacttgggt agctcaaaat actagcggtg cctgtttact     1140

tggttactcg acatattttt ttgaaagagc aggtatggcc accgacaagg cgtttacttt     1200

ttctgtaatt cagtactgtc ttgggttagc gggtacactt tgctcctggg taatatctgg     1260

ccgtgttggt agatggacaa tactgaccta tggtcttgca tttcaaatgg tctgcttatt     1320

tattattggt ggaatgggtt ttggttctgg aagcagcgct agtaatggtg ccggtggttt     1380

attgctggct ttatcattct tttacaatgc tggtatcggt gcagttgttt actgtatcgt     1440

tgctgaaatt ccatcagcgg agttgagaac taagactata gtgctggccc gtatttgcta     1500

caatctcatg gccgttatta acgctatatt aacgccctat atgctaaacg tgagcgattg     1560

gaactggggt gccaaaactg gtctatactg gggtggtttc acagcagtca ctttagcttg     1620

ggtcatcatc gatctgcctg agacaactgg tagaaccttc agtgaaatta atgaactttt     1680

caaccaaggg gttcctgcca gaaaatttgc atctactgtg gttgatccat tcggaaaggg     1740

aaaaactcaa catgattcgc tagctgatga gagtatcagt cagtcctcaa gcataaaaca     1800

gcgagaatta aatgcagctg ataaatgtta acctgcaggt ttgccagctt actatccttc     1860

ttgaaaatat gcactctata tcttttagtt cttaattgca acacatagat ttgctgtata     1920

acgaatttta tgctattttt taaatttgga gttcagtgat aaaagtgtca cagcgaattt     1980

cctcacatgt agggaccgaa ttgtttacaa gttctctgta ccaccatgga gacatcaaaa     2040

attgaaaatc tatggaaaga tatggacggt agcaacaaga atatagcacg agccggcgct     2100

agcgagctct aatgattcaa gaaaaagttc aaataaacta atggatcaac ctatttcgac     2160

cctttcttca ttgctacttc ttccttaagc aacagatgat taagtagata ctgttttttt     2220

agccaatagt atctcgccga ggagttatac ttgactagct cttgctcaag aatcttccta     2280

agacgtacta gcctagcata gtaatctgtt tgtttctgta ttgtttgttc taactgttct     2340

acagtcattg aatcaatatc tccaatgtct tcgacgttga caactttccc ccccttggca     2400

gcattctctt ttttgttgga atacgacatt aaagattcct tgattttctg ggtaccttca     2460

atgaccattg agggattaaa tttgatttct ttgattttat aatggtcggc tattagctct     2520

tccacttcgt catcatgatc atcagatatg tcacgttgcc ttttcaattt attaaaattg     2580

tttatcagtt tattgtgatc ttgtatcaat tcattgcgta ctcttttctc aatatcaaaa     2640

gctattttct tcccgctaga ctcaaaatca actctgaagt cattttctcg ctggaattca     2700

tgtatttcat ggattaattc tctattgata ttctcgtatg catcctgtaa actgttgccg     2760

ttgatattat gaaccgcctt taaatgtttc aataaggcat ctgctctagt aaatgccttc     2820

agacattcag gtaataaaca gtaaaatggc ttctcggctg tatgcgtcct aatgtttaaa     2880

ccgtcaaaag ggcgacaccc cctaattagc                                      2910


<210>  25
<211>  617
<212>  PRT
<213>  SACCHAROMYCES MIKATAE

<400>  25

Met Lys Asn Phe Ile Ser Leu Val Asn Lys Lys Lys Gly Thr Leu Asp 
1               5                   10                  15      


Asp Arg Asn Ser Ser Val Pro Glu Ser Ser Ser Gly Ile Ile His Gln 
            20                  25                  30          


Arg Gly Ala Leu Asn Thr Glu Asp Phe Glu Glu Gly Lys Lys Asp Gly 
        35                  40                  45              


Ala Phe Glu Leu Gly His Leu Glu Phe Thr Thr Asn Ser Ala Gln Leu 
    50                  55                  60                  


Gly Asp Ser Asp Asp Asp Asn Asp Asn Ala Ile Lys Ile Ala Asn Ala 
65                  70                  75                  80  


Ala Thr Asp Glu Ala Asn Glu Ala Asn Ser Glu Glu Lys Ser Met Thr 
                85                  90                  95      


Leu Arg Gln Ala Leu Arg Lys Tyr Pro Lys Ala Ala Leu Trp Ser Ile 
            100                 105                 110         


Leu Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ala Leu Leu 
        115                 120                 125             


Ser Ala Leu Tyr Ala Leu Pro Val Phe Gln Arg Lys Phe Gly Thr Met 
    130                 135                 140                 


Asn Ala Glu Gly Ser Tyr Glu Ile Thr Ser Gln Trp Gln Ile Gly Leu 
145                 150                 155                 160 


Asn Met Cys Val Leu Cys Gly Glu Met Ile Gly Leu Gln Met Thr Thr 
                165                 170                 175     


Tyr Met Val Glu Phe Met Gly Asn Arg Tyr Thr Met Ile Thr Ala Leu 
            180                 185                 190         


Gly Leu Leu Thr Ala Tyr Ile Phe Ile Leu Tyr Tyr Cys Lys Ser Leu 
        195                 200                 205             


Ala Met Ile Ala Val Gly Gln Ile Leu Ser Ala Met Pro Trp Gly Cys 
    210                 215                 220                 


Phe Gln Ser Leu Ala Val Thr Tyr Ala Ser Glu Val Cys Pro Leu Ala 
225                 230                 235                 240 


Leu Arg Tyr Tyr Met Thr Ser Tyr Ser Asn Ile Cys Trp Leu Phe Gly 
                245                 250                 255     


Gln Ile Phe Ala Ser Gly Ile Met Lys Asn Ser Gln Glu Asn Leu Gly 
            260                 265                 270         


Asp Ser Asp Leu Gly Tyr Lys Leu Pro Phe Ala Leu Gln Trp Ile Trp 
        275                 280                 285             


Pro Ala Pro Leu Ile Ile Gly Ile Phe Phe Ala Pro Glu Ser Pro Trp 
    290                 295                 300                 


Trp Leu Val Arg Lys Asn Lys Ile Ala Glu Ala Lys Lys Ser Leu Asn 
305                 310                 315                 320 


Arg Ile Leu Ser Gly Thr Ala Ala Glu Arg Glu Ile Gln Val Asp Ile 
                325                 330                 335     


Thr Leu Lys Gln Ile Glu Met Thr Ile Glu Lys Glu Arg Leu Leu Ala 
            340                 345                 350         


Ser Lys Ser Gly Ser Phe Phe Asn Cys Phe Lys Gly Val Asp Gly Arg 
        355                 360                 365             


Arg Thr Arg Leu Ala Cys Leu Thr Trp Val Ala Gln Asn Ser Ser Gly 
    370                 375                 380                 


Ala Val Leu Leu Gly Tyr Ser Thr Tyr Phe Phe Glu Arg Ala Gly Met 
385                 390                 395                 400 


Ala Thr Asp Lys Ala Phe Thr Phe Ser Leu Ile Gln Tyr Cys Leu Gly 
                405                 410                 415     


Leu Ala Gly Thr Leu Cys Ser Trp Val Ile Ser Gly Arg Val Gly Arg 
            420                 425                 430         


Trp Ser Ile Leu Ala Tyr Gly Leu Ala Phe Gln Met Val Cys Leu Phe 
        435                 440                 445             


Ile Ile Gly Gly Met Gly Phe Ala Ser Gly Ser Asn Ala Ser Asn Gly 
    450                 455                 460                 


Ala Gly Gly Leu Leu Leu Ala Leu Ser Phe Phe Tyr Asn Ala Gly Ile 
465                 470                 475                 480 


Gly Ala Val Val Tyr Cys Ile Val Ala Glu Ile Pro Ser Ala Glu Leu 
                485                 490                 495     


Arg Thr Lys Thr Ile Val Met Ala Arg Ile Cys Tyr Asn Leu Met Ala 
            500                 505                 510         


Val Ile Asn Ala Ile Leu Thr Pro Tyr Met Leu Asn Val Ser Asp Trp 
        515                 520                 525             


Asn Trp Gly Ala Lys Thr Gly Leu Tyr Trp Gly Gly Phe Thr Ala Val 
    530                 535                 540                 


Thr Leu Ala Trp Val Ile Ile Asp Leu Pro Glu Thr Thr Gly Arg Thr 
545                 550                 555                 560 


Phe Ser Glu Ile Asn Glu Leu Phe Asn Gln Gly Val Pro Ala Arg Lys 
                565                 570                 575     


Phe Ala Ser Thr Val Val Asp Pro Phe Gly Lys Gly Gln Arg Gln Asn 
            580                 585                 590         


Asp Ser Gln Val Asp Asn Val Ile Asp Gln Ser Ser Ser Ala Met Gln 
        595                 600                 605             


Gln Glu Leu Asn Glu Ala Asn Glu Phe 
    610                 615         


