                         SEQUENCE LISTING

<110>  The Government of the United States of America as 
       represented by the Secretary of the Department of Health and 
       Human Services
       Kinney, Claire YH
 
<120>  CHIMERIC WEST NILE/DENGUE VIRUSES AND METHODS OF USE

<130>  4239-93048-02

<150>  US 62/015,265
<151>  2014-06-20

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  11029
<212>  DNA
<213>  West Nile virus


<220>
<221>  CDS
<222>  (97)..(10398)

<400>  1
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcg atg tct aag aaa cca gga        114
                                        Met Ser Lys Lys Pro Gly           
                                        1               5                 

ggg ccc ggc aag agc cgg gct gtc aat atg cta aaa cgc gga atg ccc        162
Gly Pro Gly Lys Ser Arg Ala Val Asn Met Leu Lys Arg Gly Met Pro           
            10                  15                  20                    

cgc gtg ttg tcc ttg att gga ctg aag agg gct atg ttg agc ctg atc        210
Arg Val Leu Ser Leu Ile Gly Leu Lys Arg Ala Met Leu Ser Leu Ile           
        25                  30                  35                        

gac ggc aag ggg cca ata cga ttt gtg ttg gct ctc ttg gcg ttc ttc        258
Asp Gly Lys Gly Pro Ile Arg Phe Val Leu Ala Leu Leu Ala Phe Phe           
    40                  45                  50                            

agg ttc aca gca att gct ccg acc cga gca gtg ctg gat cga tgg aga        306
Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala Val Leu Asp Arg Trp Arg           
55                  60                  65                  70            

ggt gtg aac aaa caa aca gcg atg aaa cac ctt ctg agt ttt aag aag        354
Gly Val Asn Lys Gln Thr Ala Met Lys His Leu Leu Ser Phe Lys Lys           
                75                  80                  85                

gaa cta ggg acc ttg acc agt gct atc aat cgg cgg agc tca aaa caa        402
Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn Arg Arg Ser Ser Lys Gln           
            90                  95                  100                   

aag aaa aga gga gga aag acc gga att gca gtc atg att ggc ctg atc        450
Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala Val Met Ile Gly Leu Ile           
        105                 110                 115                       

gcc agc gta gga gca gtt acc ctc tct aac ttc caa ggg aag gtg atg        498
Ala Ser Val Gly Ala Val Thr Leu Ser Asn Phe Gln Gly Lys Val Met           
    120                 125                 130                           

atg acg gta aat gct act gac gtc aca gat gtc atc acg att cca aca        546
Met Thr Val Asn Ala Thr Asp Val Thr Asp Val Ile Thr Ile Pro Thr           
135                 140                 145                 150           

gct gct gga aag aac cta tgc att gtc aga gca atg gat gtg gga tac        594
Ala Ala Gly Lys Asn Leu Cys Ile Val Arg Ala Met Asp Val Gly Tyr           
                155                 160                 165               

atg tgc gat gat act atc act tat gaa tgc cca gtg ctg tcg gct ggt        642
Met Cys Asp Asp Thr Ile Thr Tyr Glu Cys Pro Val Leu Ser Ala Gly           
            170                 175                 180                   

aat gat cca gaa gac atc gac tgt tgg tgc aca aag tca gca gtc tac        690
Asn Asp Pro Glu Asp Ile Asp Cys Trp Cys Thr Lys Ser Ala Val Tyr           
        185                 190                 195                       

gtc agg tat gga aga tgc acc aag aca cgc cac tca aga cgc agt cgg        738
Val Arg Tyr Gly Arg Cys Thr Lys Thr Arg His Ser Arg Arg Ser Arg           
    200                 205                 210                           

agg tca ctg aca gtg cag aca cac gga gaa agc act cta gcg aac aag        786
Arg Ser Leu Thr Val Gln Thr His Gly Glu Ser Thr Leu Ala Asn Lys           
215                 220                 225                 230           

aag ggg gct tgg atg gac agc acc aag gcc aca agg tat ttg gta aaa        834
Lys Gly Ala Trp Met Asp Ser Thr Lys Ala Thr Arg Tyr Leu Val Lys           
                235                 240                 245               

aca gaa tca tgg atc ttg agg aac cct gga tat gcc ctg gtg gca gcc        882
Thr Glu Ser Trp Ile Leu Arg Asn Pro Gly Tyr Ala Leu Val Ala Ala           
            250                 255                 260                   

gtc att ggt tgg atg ctt ggg agc aac acc atg cag aga gtt gtg ttt        930
Val Ile Gly Trp Met Leu Gly Ser Asn Thr Met Gln Arg Val Val Phe           
        265                 270                 275                       

gtc gtg cta ttg ctt ttg gtg gcc cca gct tac agc ttc aac tgc ctt        978
Val Val Leu Leu Leu Leu Val Ala Pro Ala Tyr Ser Phe Asn Cys Leu           
    280                 285                 290                           

gga atg agc aac aga gac ttc ttg gaa gga gtg tct gga gca aca tgg       1026
Gly Met Ser Asn Arg Asp Phe Leu Glu Gly Val Ser Gly Ala Thr Trp           
295                 300                 305                 310           

gtg gat ttg gtt ctc gaa ggc gac agc tgc gtg act atc atg tct aag       1074
Val Asp Leu Val Leu Glu Gly Asp Ser Cys Val Thr Ile Met Ser Lys           
                315                 320                 325               

gac aag cct acc atc gat gtg aag atg atg aat atg gag gcg gcc aac       1122
Asp Lys Pro Thr Ile Asp Val Lys Met Met Asn Met Glu Ala Ala Asn           
            330                 335                 340                   

ctg gca gag gtc cgc agt tat tgc tat ttg gct acc gtc agc gat ctc       1170
Leu Ala Glu Val Arg Ser Tyr Cys Tyr Leu Ala Thr Val Ser Asp Leu           
        345                 350                 355                       

tcc acc aaa gct gcg tgc ccg acc atg gga gaa gct cac aat gac aaa       1218
Ser Thr Lys Ala Ala Cys Pro Thr Met Gly Glu Ala His Asn Asp Lys           
    360                 365                 370                           

cgt gct gac cca gct ttt gtg tgc aga caa gga gtg gtg gac agg ggc       1266
Arg Ala Asp Pro Ala Phe Val Cys Arg Gln Gly Val Val Asp Arg Gly           
375                 380                 385                 390           

tgg ggc aac ggc tgc gga cta ttt ggc aaa gga agc att gac aca tgc       1314
Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Ile Asp Thr Cys           
                395                 400                 405               

gcc aaa ttt gcc tgc tct acc aag gca ata gga aga acc atc ttg aaa       1362
Ala Lys Phe Ala Cys Ser Thr Lys Ala Ile Gly Arg Thr Ile Leu Lys           
            410                 415                 420                   

gag aat atc aag tac gaa gtg gcc att ttt gtc cat gga cca act act       1410
Glu Asn Ile Lys Tyr Glu Val Ala Ile Phe Val His Gly Pro Thr Thr           
        425                 430                 435                       

gtg gag tcg cac gga aat tac tcc aca cag gtt gga gcc act cag gca       1458
Val Glu Ser His Gly Asn Tyr Ser Thr Gln Val Gly Ala Thr Gln Ala           
    440                 445                 450                           

ggg aga ttc agc atc act cct gcg gcg cct tca tac aca cta aag ctt       1506
Gly Arg Phe Ser Ile Thr Pro Ala Ala Pro Ser Tyr Thr Leu Lys Leu           
455                 460                 465                 470           

gga gaa tat gga gag gtg aca gtg gac tgt gaa cca cgg tca ggg att       1554
Gly Glu Tyr Gly Glu Val Thr Val Asp Cys Glu Pro Arg Ser Gly Ile           
                475                 480                 485               

gac acc aat gca tac tac gtg atg act gtt gga aca aag acg ttc ttg       1602
Asp Thr Asn Ala Tyr Tyr Val Met Thr Val Gly Thr Lys Thr Phe Leu           
            490                 495                 500                   

gtc cat cgt gag tgg ttc atg gac ctc aac ctc cct tgg agc agt gct       1650
Val His Arg Glu Trp Phe Met Asp Leu Asn Leu Pro Trp Ser Ser Ala           
        505                 510                 515                       

gga agt act gtg tgg agg aac aga gag acg tta atg gag ttt gag gaa       1698
Gly Ser Thr Val Trp Arg Asn Arg Glu Thr Leu Met Glu Phe Glu Glu           
    520                 525                 530                           

cca cac gcc acg aag cag tct gtg ata gca ttg ggc tca caa gag gga       1746
Pro His Ala Thr Lys Gln Ser Val Ile Ala Leu Gly Ser Gln Glu Gly           
535                 540                 545                 550           

gct ctg cat caa gct ttg gct gga gcc att cct gtg gaa ttt tca agc       1794
Ala Leu His Gln Ala Leu Ala Gly Ala Ile Pro Val Glu Phe Ser Ser           
                555                 560                 565               

aac act gtc aag ttg acg tcg ggt cat ttg aag tgt aga gtg aag atg       1842
Asn Thr Val Lys Leu Thr Ser Gly His Leu Lys Cys Arg Val Lys Met           
            570                 575                 580                   

gaa aaa ttg cag ctg aag gga aca acc tat ggc gtc tgt tca aag gct       1890
Glu Lys Leu Gln Leu Lys Gly Thr Thr Tyr Gly Val Cys Ser Lys Ala           
        585                 590                 595                       

ttc aag ttt ctt ggg act ccc gca gac aca ggt cac ggc act gtg gtg       1938
Phe Lys Phe Leu Gly Thr Pro Ala Asp Thr Gly His Gly Thr Val Val           
    600                 605                 610                           

ttg gaa ttg cag tac act ggc acg gat gga cct tgc aaa gtt cct atc       1986
Leu Glu Leu Gln Tyr Thr Gly Thr Asp Gly Pro Cys Lys Val Pro Ile           
615                 620                 625                 630           

tcg tca gtg gct tca ttg aac gac cta acg cca gtg ggc aga ttg gtc       2034
Ser Ser Val Ala Ser Leu Asn Asp Leu Thr Pro Val Gly Arg Leu Val           
                635                 640                 645               

act gtc aac cct ttt gtt tca gtg gcc acg gcc aac gct aag gtc ctg       2082
Thr Val Asn Pro Phe Val Ser Val Ala Thr Ala Asn Ala Lys Val Leu           
            650                 655                 660                   

att gaa ttg gaa cca ccc ttt gga gac tca tac ata gtg gtg ggc aga       2130
Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Val Gly Arg           
        665                 670                 675                       

gga gaa caa cag atc aat cac cat tgg cac aag tct gga agc agc att       2178
Gly Glu Gln Gln Ile Asn His His Trp His Lys Ser Gly Ser Ser Ile           
    680                 685                 690                           

ggc aaa gcc ttt aca acc acc ctc aaa gga gcg cag aga cta gcc gct       2226
Gly Lys Ala Phe Thr Thr Thr Leu Lys Gly Ala Gln Arg Leu Ala Ala           
695                 700                 705                 710           

cta gga gac aca gct tgg gac ttt gga tca gtt gga ggg gtg ttc acc       2274
Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Phe Thr           
                715                 720                 725               

tca gtt ggg aag gct gtc cat caa gtg ttc gga gga gca ttc cgc tca       2322
Ser Val Gly Lys Ala Val His Gln Val Phe Gly Gly Ala Phe Arg Ser           
            730                 735                 740                   

ctg ttc gga ggc atg tcc tgg ata acg caa gga ttg ctg ggg gct ctc       2370
Leu Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu Leu Gly Ala Leu           
        745                 750                 755                       

ctg ttg tgg atg ggc atc aat gct cgt gat agg tcc ata gct ctc acg       2418
Leu Leu Trp Met Gly Ile Asn Ala Arg Asp Arg Ser Ile Ala Leu Thr           
    760                 765                 770                           

ttt ctc gca gtt gga gga gtt ctg ctc ttc ctc tcc gtg aac gtg cac       2466
Phe Leu Ala Val Gly Gly Val Leu Leu Phe Leu Ser Val Asn Val His           
775                 780                 785                 790           

gct gac act ggg tgt gcc ata gac atc agc cgg caa gag ctg aga tgt       2514
Ala Asp Thr Gly Cys Ala Ile Asp Ile Ser Arg Gln Glu Leu Arg Cys           
                795                 800                 805               

gga agt gga gtg ttc ata cac aat gat gtg gag gct tgg atg gac cgg       2562
Gly Ser Gly Val Phe Ile His Asn Asp Val Glu Ala Trp Met Asp Arg           
            810                 815                 820                   

tac aag tat tac cct gaa acg cca caa ggc cta gcc aag atc att cag       2610
Tyr Lys Tyr Tyr Pro Glu Thr Pro Gln Gly Leu Ala Lys Ile Ile Gln           
        825                 830                 835                       

aaa gct cat aag gaa gga gtg tgc ggt cta cga tca gtt tcc aga ctg       2658
Lys Ala His Lys Glu Gly Val Cys Gly Leu Arg Ser Val Ser Arg Leu           
    840                 845                 850                           

gag cat caa atg tgg gaa gca gtg aag gac gag ctg aac act ctt ttg       2706
Glu His Gln Met Trp Glu Ala Val Lys Asp Glu Leu Asn Thr Leu Leu           
855                 860                 865                 870           

aag gag aat ggt gtg gac ctt agt gtc gtg gtt gag aaa cag gag gga       2754
Lys Glu Asn Gly Val Asp Leu Ser Val Val Val Glu Lys Gln Glu Gly           
                875                 880                 885               

atg tac aag tca gca cct aaa cgc ctc acc gcc acc acg gaa aaa ttg       2802
Met Tyr Lys Ser Ala Pro Lys Arg Leu Thr Ala Thr Thr Glu Lys Leu           
            890                 895                 900                   

gaa att ggc tgg aag gcc tgg gga aag agt att tta ttt gca cca gaa       2850
Glu Ile Gly Trp Lys Ala Trp Gly Lys Ser Ile Leu Phe Ala Pro Glu           
        905                 910                 915                       

ctc gcc aac aac acc ttt gtg gtt gat ggt ccg gag acc aag gaa tgt       2898
Leu Ala Asn Asn Thr Phe Val Val Asp Gly Pro Glu Thr Lys Glu Cys           
    920                 925                 930                           

ccg act cag aat cgc gct tgg aat agc tta gaa gtg gag gat ttt gga       2946
Pro Thr Gln Asn Arg Ala Trp Asn Ser Leu Glu Val Glu Asp Phe Gly           
935                 940                 945                 950           

ttt ggt ctc acc agc act cgg atg ttc ctg aag gtc aga gag agc aac       2994
Phe Gly Leu Thr Ser Thr Arg Met Phe Leu Lys Val Arg Glu Ser Asn           
                955                 960                 965               

aca act gaa tgt gac tcg aag atc att gga acg gct gtc aag aac aac       3042
Thr Thr Glu Cys Asp Ser Lys Ile Ile Gly Thr Ala Val Lys Asn Asn           
            970                 975                 980                   

ttg gcg atc cac agt gac ctg tcc tat tgg att gaa agc agg ctc aat       3090
Leu Ala Ile His Ser Asp Leu Ser Tyr Trp Ile Glu Ser Arg Leu Asn           
        985                 990                 995                       

gat acg  tgg aag ctt gaa agg  gca gtt ctg ggt gaa  gtc aaa tca        3135
Asp Thr  Trp Lys Leu Glu Arg  Ala Val Leu Gly Glu  Val Lys Ser            
    1000                 1005                 1010                        

tgt acg  tgg cct gag acg cat  acc ttg tgg ggc gat  gga atc ctt        3180
Cys Thr  Trp Pro Glu Thr His  Thr Leu Trp Gly Asp  Gly Ile Leu            
    1015                 1020                 1025                        

gag agt  gac ttg ata ata cca  gtc aca ctg gcg gga  cca cga agc        3225
Glu Ser  Asp Leu Ile Ile Pro  Val Thr Leu Ala Gly  Pro Arg Ser            
    1030                 1035                 1040                        

aat cac  aat cgg aga cct ggg  tac aag aca caa aac  cag ggc cca        3270
Asn His  Asn Arg Arg Pro Gly  Tyr Lys Thr Gln Asn  Gln Gly Pro            
    1045                 1050                 1055                        

tgg gac  gaa ggc cgg gta gag  att gac ttc gat tac  tgc cca gga        3315
Trp Asp  Glu Gly Arg Val Glu  Ile Asp Phe Asp Tyr  Cys Pro Gly            
    1060                 1065                 1070                        

act acg  gtc acc ctg agt gag  agc tgc gga cac cgt  gga cct gcc        3360
Thr Thr  Val Thr Leu Ser Glu  Ser Cys Gly His Arg  Gly Pro Ala            
    1075                 1080                 1085                        

act cgc  acc acc aca gag agc  gga aag ttg ata aca  gat tgg tgc        3405
Thr Arg  Thr Thr Thr Glu Ser  Gly Lys Leu Ile Thr  Asp Trp Cys            
    1090                 1095                 1100                        

tgc agg  agc tgc acc tta cca  cca ctg cgc tac caa  act gac agc        3450
Cys Arg  Ser Cys Thr Leu Pro  Pro Leu Arg Tyr Gln  Thr Asp Ser            
    1105                 1110                 1115                        

ggc tgt  tgg tat ggt atg gag  atc aga cca cag aga  cat gat gaa        3495
Gly Cys  Trp Tyr Gly Met Glu  Ile Arg Pro Gln Arg  His Asp Glu            
    1120                 1125                 1130                        

aag acc  ctc gtg cag tca caa  gtg aat gct tat aat  gct gat atg        3540
Lys Thr  Leu Val Gln Ser Gln  Val Asn Ala Tyr Asn  Ala Asp Met            
    1135                 1140                 1145                        

att gac  cct ttt cag ttg ggc  ctt ctg gtc gtg ttc  ttg gcc acc        3585
Ile Asp  Pro Phe Gln Leu Gly  Leu Leu Val Val Phe  Leu Ala Thr            
    1150                 1155                 1160                        

cag gag  gtc ctt cgc aag agg  tgg aca gcc aag atc  agc atg cca        3630
Gln Glu  Val Leu Arg Lys Arg  Trp Thr Ala Lys Ile  Ser Met Pro            
    1165                 1170                 1175                        

gct ata  ctg att gct ctg cta  gtc ctg gtg ttt ggg  ggc att act        3675
Ala Ile  Leu Ile Ala Leu Leu  Val Leu Val Phe Gly  Gly Ile Thr            
    1180                 1185                 1190                        

tac act  gat gtg tta cgc tat  gtc atc ttg gtg ggg  gca gct ttc        3720
Tyr Thr  Asp Val Leu Arg Tyr  Val Ile Leu Val Gly  Ala Ala Phe            
    1195                 1200                 1205                        

gca gaa  tct aat tcg gga gga  gac gtg gta cac ttg  gcg ctc atg        3765
Ala Glu  Ser Asn Ser Gly Gly  Asp Val Val His Leu  Ala Leu Met            
    1210                 1215                 1220                        

gcg acc  ttc aag ata caa cca  gtg ttt atg gtg gca  tcg ttt ctc        3810
Ala Thr  Phe Lys Ile Gln Pro  Val Phe Met Val Ala  Ser Phe Leu            
    1225                 1230                 1235                        

aaa gcg  aga tgg acc aac cag  gag aac att ttg ttg  atg ttg gcg        3855
Lys Ala  Arg Trp Thr Asn Gln  Glu Asn Ile Leu Leu  Met Leu Ala            
    1240                 1245                 1250                        

gct gtt  ttc ttt caa atg gct  tat tac gat gcc cgc  caa att ctg        3900
Ala Val  Phe Phe Gln Met Ala  Tyr Tyr Asp Ala Arg  Gln Ile Leu            
    1255                 1260                 1265                        

ctc tgg  gag atc cct gat gtg  ttg aat tca ctg gcg  gta gct tgg        3945
Leu Trp  Glu Ile Pro Asp Val  Leu Asn Ser Leu Ala  Val Ala Trp            
    1270                 1275                 1280                        

atg ata  ctg aga gcc ata aca  ttc aca acg aca tca  aac gtg gtt        3990
Met Ile  Leu Arg Ala Ile Thr  Phe Thr Thr Thr Ser  Asn Val Val            
    1285                 1290                 1295                        

gtt ccg  ctg cta gcc ctg cta  aca ccc ggg ctg aga  tgc ttg aat        4035
Val Pro  Leu Leu Ala Leu Leu  Thr Pro Gly Leu Arg  Cys Leu Asn            
    1300                 1305                 1310                        

ctg gat  gtg tac agg ata ctg  ctg ttg atg gtc gga  ata ggc agc        4080
Leu Asp  Val Tyr Arg Ile Leu  Leu Leu Met Val Gly  Ile Gly Ser            
    1315                 1320                 1325                        

ttg atc  agg gag aag agg agt  gca gct gca aaa aag  aaa gga gca        4125
Leu Ile  Arg Glu Lys Arg Ser  Ala Ala Ala Lys Lys  Lys Gly Ala            
    1330                 1335                 1340                        

agt ctg  cta tgc ttg gct cta  gcc tca aca gga ctt  ttc aac ccc        4170
Ser Leu  Leu Cys Leu Ala Leu  Ala Ser Thr Gly Leu  Phe Asn Pro            
    1345                 1350                 1355                        

atg atc  ctt gct gct gga ctg  att gca tgt gat ccc  aac cgt aaa        4215
Met Ile  Leu Ala Ala Gly Leu  Ile Ala Cys Asp Pro  Asn Arg Lys            
    1360                 1365                 1370                        

cgc gga  tgg ccc gca act gaa  gtg atg aca gct gtc  ggc cta atg        4260
Arg Gly  Trp Pro Ala Thr Glu  Val Met Thr Ala Val  Gly Leu Met            
    1375                 1380                 1385                        

ttt gcc  atc gtc gga ggg ctg  gca gag ctt gac att  gac tcc atg        4305
Phe Ala  Ile Val Gly Gly Leu  Ala Glu Leu Asp Ile  Asp Ser Met            
    1390                 1395                 1400                        

gcc att  cca atg act atc gcg  ggg ctc atg ttt gct  gct ttc gtg        4350
Ala Ile  Pro Met Thr Ile Ala  Gly Leu Met Phe Ala  Ala Phe Val            
    1405                 1410                 1415                        

att tct  ggg aaa tca aca gat  atg tgg att gag aga  acg gcg gac        4395
Ile Ser  Gly Lys Ser Thr Asp  Met Trp Ile Glu Arg  Thr Ala Asp            
    1420                 1425                 1430                        

att tcc  tgg gaa agt gat gca  gaa att aca ggc tcg  agc gaa aga        4440
Ile Ser  Trp Glu Ser Asp Ala  Glu Ile Thr Gly Ser  Ser Glu Arg            
    1435                 1440                 1445                        

gtt gat  gtg cgg ctt gat gat  gat gga aac ttc cag  ctc atg aat        4485
Val Asp  Val Arg Leu Asp Asp  Asp Gly Asn Phe Gln  Leu Met Asn            
    1450                 1455                 1460                        

gat cca  gga gca cct tgg aag  ata tgg atg ctc aga  atg gtc tgt        4530
Asp Pro  Gly Ala Pro Trp Lys  Ile Trp Met Leu Arg  Met Val Cys            
    1465                 1470                 1475                        

ctc gcg  att agt gcg tac acc  ccc tgg gca atc ttg  ccc tca gta        4575
Leu Ala  Ile Ser Ala Tyr Thr  Pro Trp Ala Ile Leu  Pro Ser Val            
    1480                 1485                 1490                        

gtt gga  ttt tgg ata act ctc  caa tac aca aag aga  gga ggc gtg        4620
Val Gly  Phe Trp Ile Thr Leu  Gln Tyr Thr Lys Arg  Gly Gly Val            
    1495                 1500                 1505                        

ttg tgg  gac act ccc tca cca  aag gag tac aaa aag  ggg gac acg        4665
Leu Trp  Asp Thr Pro Ser Pro  Lys Glu Tyr Lys Lys  Gly Asp Thr            
    1510                 1515                 1520                        

acc acc  ggc gtc tac agg atc  atg act cgt ggg ctg  ctc ggc agt        4710
Thr Thr  Gly Val Tyr Arg Ile  Met Thr Arg Gly Leu  Leu Gly Ser            
    1525                 1530                 1535                        

tat caa  gca gga gcg ggc gtg  atg gtt gaa ggt gtt  ttc cac acc        4755
Tyr Gln  Ala Gly Ala Gly Val  Met Val Glu Gly Val  Phe His Thr            
    1540                 1545                 1550                        

ctt tgg  cat aca aca aaa gga  gcc gct ttg atg agc  gga gag ggc        4800
Leu Trp  His Thr Thr Lys Gly  Ala Ala Leu Met Ser  Gly Glu Gly            
    1555                 1560                 1565                        

cgc ctg  gac cca tac tgg ggc  agt gtc aag gag gat  cga ctt tgt        4845
Arg Leu  Asp Pro Tyr Trp Gly  Ser Val Lys Glu Asp  Arg Leu Cys            
    1570                 1575                 1580                        

tac gga  gga ccc tgg aaa ttg  cag cac aag tgg aac  ggg cag gat        4890
Tyr Gly  Gly Pro Trp Lys Leu  Gln His Lys Trp Asn  Gly Gln Asp            
    1585                 1590                 1595                        

gag gtg  cag atg att gtg gtg  gaa cct ggc agg aac  gtt aag aac        4935
Glu Val  Gln Met Ile Val Val  Glu Pro Gly Arg Asn  Val Lys Asn            
    1600                 1605                 1610                        

gtc cag  acg aaa cca ggg gtg  ttc aaa aca cct gaa  gga gaa atc        4980
Val Gln  Thr Lys Pro Gly Val  Phe Lys Thr Pro Glu  Gly Glu Ile            
    1615                 1620                 1625                        

ggg gcc  gtg act ttg gac ttc  ccc act gga aca tca  ggc tca cca        5025
Gly Ala  Val Thr Leu Asp Phe  Pro Thr Gly Thr Ser  Gly Ser Pro            
    1630                 1635                 1640                        

ata gtg  gac aaa aac ggt gat  gtg att ggg ctt tat  ggc aat gga        5070
Ile Val  Asp Lys Asn Gly Asp  Val Ile Gly Leu Tyr  Gly Asn Gly            
    1645                 1650                 1655                        

gtc ata  atg ccc aac ggc tca  tac ata agc gcg ata  gtg cag ggt        5115
Val Ile  Met Pro Asn Gly Ser  Tyr Ile Ser Ala Ile  Val Gln Gly            
    1660                 1665                 1670                        

gaa agg  atg gat gag cca atc  cca gcc gga ttc gaa  cct gag atg        5160
Glu Arg  Met Asp Glu Pro Ile  Pro Ala Gly Phe Glu  Pro Glu Met            
    1675                 1680                 1685                        

ctg agg  aaa aaa cag atc act  gta ctg gat ctc cat  ccc ggc gcc        5205
Leu Arg  Lys Lys Gln Ile Thr  Val Leu Asp Leu His  Pro Gly Ala            
    1690                 1695                 1700                        

ggt aaa  aca agg agg att ctg  cca cag atc atc aaa  gag gcc ata        5250
Gly Lys  Thr Arg Arg Ile Leu  Pro Gln Ile Ile Lys  Glu Ala Ile            
    1705                 1710                 1715                        

aac aga  aga ctg aga aca gcc  gtg cta gca cca acc  agg gtt gtg        5295
Asn Arg  Arg Leu Arg Thr Ala  Val Leu Ala Pro Thr  Arg Val Val            
    1720                 1725                 1730                        

gct gct  gag atg gct gaa gca  ctg aga gga ctg ccc  atc cgg tac        5340
Ala Ala  Glu Met Ala Glu Ala  Leu Arg Gly Leu Pro  Ile Arg Tyr            
    1735                 1740                 1745                        

cag aca  tcc gca gtg ccc aga  gaa cat aat gga aat  gag att gtt        5385
Gln Thr  Ser Ala Val Pro Arg  Glu His Asn Gly Asn  Glu Ile Val            
    1750                 1755                 1760                        

gat gtc  atg tgt cat gct acc  ctc acc cac agg ctg  atg tct cct        5430
Asp Val  Met Cys His Ala Thr  Leu Thr His Arg Leu  Met Ser Pro            
    1765                 1770                 1775                        

cac agg  gtg ccg aac tac aac  ctg ttc gtg atg gat  gag gct cat        5475
His Arg  Val Pro Asn Tyr Asn  Leu Phe Val Met Asp  Glu Ala His            
    1780                 1785                 1790                        

ttc acc  gac cca gct agc att  gca gca aga ggt tac  att tcc aca        5520
Phe Thr  Asp Pro Ala Ser Ile  Ala Ala Arg Gly Tyr  Ile Ser Thr            
    1795                 1800                 1805                        

aag gtc  gag cta ggg gag gcg  gcg gca ata ttc atg  aca gcc acc        5565
Lys Val  Glu Leu Gly Glu Ala  Ala Ala Ile Phe Met  Thr Ala Thr            
    1810                 1815                 1820                        

cca cca  ggc act tca gat cca  ttc cca gag tcc aat  tca cca att        5610
Pro Pro  Gly Thr Ser Asp Pro  Phe Pro Glu Ser Asn  Ser Pro Ile            
    1825                 1830                 1835                        

tcc gac  tta cag act gag atc  ccg gat cga gct tgg  aac tct gga        5655
Ser Asp  Leu Gln Thr Glu Ile  Pro Asp Arg Ala Trp  Asn Ser Gly            
    1840                 1845                 1850                        

tac gaa  tgg atc aca gaa tac  acc ggg aag acg gtt  tgg ttt gtg        5700
Tyr Glu  Trp Ile Thr Glu Tyr  Thr Gly Lys Thr Val  Trp Phe Val            
    1855                 1860                 1865                        

cct agt  gtc aag atg ggg aat  gag att gcc ctt tgc  cta caa cgt        5745
Pro Ser  Val Lys Met Gly Asn  Glu Ile Ala Leu Cys  Leu Gln Arg            
    1870                 1875                 1880                        

gct gga  aag aaa gta gtc caa  ttg aac aga aag tcg  tac gag acg        5790
Ala Gly  Lys Lys Val Val Gln  Leu Asn Arg Lys Ser  Tyr Glu Thr            
    1885                 1890                 1895                        

gag tac  cca aaa tgt aag aac  gat gat tgg gac ttt  gtt atc aca        5835
Glu Tyr  Pro Lys Cys Lys Asn  Asp Asp Trp Asp Phe  Val Ile Thr            
    1900                 1905                 1910                        

aca gac  ata tct gaa atg ggg  gct aac ttc aag gcg  agc agg gtg        5880
Thr Asp  Ile Ser Glu Met Gly  Ala Asn Phe Lys Ala  Ser Arg Val            
    1915                 1920                 1925                        

att gac  agc cgg aag agt gtg  aaa cca acc atc ata  aca gaa gga        5925
Ile Asp  Ser Arg Lys Ser Val  Lys Pro Thr Ile Ile  Thr Glu Gly            
    1930                 1935                 1940                        

gaa ggg  aga gtg atc ctg gga  gaa cca tct gca gtg  aca gca gct        5970
Glu Gly  Arg Val Ile Leu Gly  Glu Pro Ser Ala Val  Thr Ala Ala            
    1945                 1950                 1955                        

agt gcc  gcc cag aga cgt gga  cgt atc ggt aga aat  ccg tcg caa        6015
Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Ser Gln            
    1960                 1965                 1970                        

gtt ggt  gat gag tac tgt tat  ggg ggg cac acg aat  gaa gac gac        6060
Val Gly  Asp Glu Tyr Cys Tyr  Gly Gly His Thr Asn  Glu Asp Asp            
    1975                 1980                 1985                        

tcg aac  ttc gcc cat tgg act  gag gca cga atc atg  ctg gac aac        6105
Ser Asn  Phe Ala His Trp Thr  Glu Ala Arg Ile Met  Leu Asp Asn            
    1990                 1995                 2000                        

atc aac  atg cca aac gga ctg  atc gct caa ttc tac  caa cca gag        6150
Ile Asn  Met Pro Asn Gly Leu  Ile Ala Gln Phe Tyr  Gln Pro Glu            
    2005                 2010                 2015                        

cgt gag  aag gta tat acc atg  gat ggg gaa tac cgg  ctc aga gga        6195
Arg Glu  Lys Val Tyr Thr Met  Asp Gly Glu Tyr Arg  Leu Arg Gly            
    2020                 2025                 2030                        

gaa gag  aga aaa aac ttt ctg  gaa ctg ttg agg act  gca gat ctg        6240
Glu Glu  Arg Lys Asn Phe Leu  Glu Leu Leu Arg Thr  Ala Asp Leu            
    2035                 2040                 2045                        

cca gtt  tgg ctg gct tac aag  gtt gca gcg gct gga  gtg tca tac        6285
Pro Val  Trp Leu Ala Tyr Lys  Val Ala Ala Ala Gly  Val Ser Tyr            
    2050                 2055                 2060                        

cac gac  cgg agg tgg tgc ttt  gat ggt cct agg aca  aac aca att        6330
His Asp  Arg Arg Trp Cys Phe  Asp Gly Pro Arg Thr  Asn Thr Ile            
    2065                 2070                 2075                        

tta gaa  gac aac aac gaa gtg  gaa gtc atc acg aag  ctt ggt gaa        6375
Leu Glu  Asp Asn Asn Glu Val  Glu Val Ile Thr Lys  Leu Gly Glu            
    2080                 2085                 2090                        

agg aag  att ctg agg ccg cgc  tgg att gac gcc agg  gtg tac tcg        6420
Arg Lys  Ile Leu Arg Pro Arg  Trp Ile Asp Ala Arg  Val Tyr Ser            
    2095                 2100                 2105                        

gat cac  cag gca cta aag gcg  ttc aag gac ttc gcc  tcg gga aaa        6465
Asp His  Gln Ala Leu Lys Ala  Phe Lys Asp Phe Ala  Ser Gly Lys            
    2110                 2115                 2120                        

cgt tct  cag ata ggg ctc att  gag gtt ctg gga aag  atg cct gag        6510
Arg Ser  Gln Ile Gly Leu Ile  Glu Val Leu Gly Lys  Met Pro Glu            
    2125                 2130                 2135                        

cac ttc  atg ggg aag aca tgg  gaa gca ctt gac acc  atg tac gtt        6555
His Phe  Met Gly Lys Thr Trp  Glu Ala Leu Asp Thr  Met Tyr Val            
    2140                 2145                 2150                        

gtg gcc  act gca gag aaa gga  gga aga gct cac aga  atg gcc ctg        6600
Val Ala  Thr Ala Glu Lys Gly  Gly Arg Ala His Arg  Met Ala Leu            
    2155                 2160                 2165                        

gag gaa  ctg cca gat gct ctt  cag aca att gcc ttg  att gcc tta        6645
Glu Glu  Leu Pro Asp Ala Leu  Gln Thr Ile Ala Leu  Ile Ala Leu            
    2170                 2175                 2180                        

ttg agt  gtg atg acc atg gga  gta ttc ttc ctc ctc  atg cag cgg        6690
Leu Ser  Val Met Thr Met Gly  Val Phe Phe Leu Leu  Met Gln Arg            
    2185                 2190                 2195                        

aag ggc  att gga aag ata ggt  ttg gga ggc gct gtc  ttg gga gtc        6735
Lys Gly  Ile Gly Lys Ile Gly  Leu Gly Gly Ala Val  Leu Gly Val            
    2200                 2205                 2210                        

gcg acc  ttt ttc tgt tgg atg  gct gaa gtt cca gga  acg aag atc        6780
Ala Thr  Phe Phe Cys Trp Met  Ala Glu Val Pro Gly  Thr Lys Ile            
    2215                 2220                 2225                        

gcc gga  atg ttg ctg ctc tcc  ctt ctc ttg atg att  gtg cta att        6825
Ala Gly  Met Leu Leu Leu Ser  Leu Leu Leu Met Ile  Val Leu Ile            
    2230                 2235                 2240                        

cct gag  cca gag aag caa cgt  tcg cag aca gac aac  cag cta gcc        6870
Pro Glu  Pro Glu Lys Gln Arg  Ser Gln Thr Asp Asn  Gln Leu Ala            
    2245                 2250                 2255                        

gtg ttc  ctg att tgt gtc atg  acc ctt gtg agc gca  gtg gca gcc        6915
Val Phe  Leu Ile Cys Val Met  Thr Leu Val Ser Ala  Val Ala Ala            
    2260                 2265                 2270                        

aac gag  atg ggt tgg cta gat  aag acc aag agt gac  ata agc agt        6960
Asn Glu  Met Gly Trp Leu Asp  Lys Thr Lys Ser Asp  Ile Ser Ser            
    2275                 2280                 2285                        

ttg ttt  ggg caa aga att gag  gtc aag gag aat ttc  agc atg gga        7005
Leu Phe  Gly Gln Arg Ile Glu  Val Lys Glu Asn Phe  Ser Met Gly            
    2290                 2295                 2300                        

gag ttt  ctt ttg gac ttg agg  cct gca aca gcc tgg  tca ctg tac        7050
Glu Phe  Leu Leu Asp Leu Arg  Pro Ala Thr Ala Trp  Ser Leu Tyr            
    2305                 2310                 2315                        

gct gtg  aca aca gcg gtc ctc  act cca ctg cta aag  cat ttg atc        7095
Ala Val  Thr Thr Ala Val Leu  Thr Pro Leu Leu Lys  His Leu Ile            
    2320                 2325                 2330                        

acg tca  gat tac atc aac acc  tca ttg acc tca ata  aac gtt cag        7140
Thr Ser  Asp Tyr Ile Asn Thr  Ser Leu Thr Ser Ile  Asn Val Gln            
    2335                 2340                 2345                        

gca agt  gca cta ttc aca ctc  gcg cga ggc ttc ccc  ttc gtc gat        7185
Ala Ser  Ala Leu Phe Thr Leu  Ala Arg Gly Phe Pro  Phe Val Asp            
    2350                 2355                 2360                        

gtt gga  gtg tcg gct ctc ctg  cta gca gcc gga tgc  tgg gga caa        7230
Val Gly  Val Ser Ala Leu Leu  Leu Ala Ala Gly Cys  Trp Gly Gln            
    2365                 2370                 2375                        

gtc acc  ctc acc gtt acg gta  aca gcg gca aca ctc  ctt ttt tgc        7275
Val Thr  Leu Thr Val Thr Val  Thr Ala Ala Thr Leu  Leu Phe Cys            
    2380                 2385                 2390                        

cac tat  gcc tac atg gtt ccc  ggt tgg caa gct gag  gca atg cgc        7320
His Tyr  Ala Tyr Met Val Pro  Gly Trp Gln Ala Glu  Ala Met Arg            
    2395                 2400                 2405                        

tca gcc  cag cgg cgg aca gcg  gcc gga atc atg aag  aac gct gta        7365
Ser Ala  Gln Arg Arg Thr Ala  Ala Gly Ile Met Lys  Asn Ala Val            
    2410                 2415                 2420                        

gtg gat  ggc atc gtg gcc acg  gac gtc cca gaa tta  gag cgc acc        7410
Val Asp  Gly Ile Val Ala Thr  Asp Val Pro Glu Leu  Glu Arg Thr            
    2425                 2430                 2435                        

aca ccc  atc atg cag aag aaa  gtt gga cag atc atg  ctg atc ttg        7455
Thr Pro  Ile Met Gln Lys Lys  Val Gly Gln Ile Met  Leu Ile Leu            
    2440                 2445                 2450                        

gtg tct  cta gct gca gta gta  gtg aac ccg tct gtg  aag aca gta        7500
Val Ser  Leu Ala Ala Val Val  Val Asn Pro Ser Val  Lys Thr Val            
    2455                 2460                 2465                        

cga gaa  gcc gga att ttg atc  acg gcc gca gcg gtg  acg ctt tgg        7545
Arg Glu  Ala Gly Ile Leu Ile  Thr Ala Ala Ala Val  Thr Leu Trp            
    2470                 2475                 2480                        

gag aat  gga gca agc tct gtt  tgg aac gca aca act  gcc atc gga        7590
Glu Asn  Gly Ala Ser Ser Val  Trp Asn Ala Thr Thr  Ala Ile Gly            
    2485                 2490                 2495                        

ctc tgc  cac atc atg cgt ggg  ggt tgg ttg tca tgt  cta tcc ata        7635
Leu Cys  His Ile Met Arg Gly  Gly Trp Leu Ser Cys  Leu Ser Ile            
    2500                 2505                 2510                        

aca tgg  aca ctc ata aag aac  atg gaa aaa cca gga  cta aaa aga        7680
Thr Trp  Thr Leu Ile Lys Asn  Met Glu Lys Pro Gly  Leu Lys Arg            
    2515                 2520                 2525                        

ggt ggg  gca aaa gga cgc acc  ttg gga gag gtt tgg  aaa gaa aga        7725
Gly Gly  Ala Lys Gly Arg Thr  Leu Gly Glu Val Trp  Lys Glu Arg            
    2530                 2535                 2540                        

ctc aac  cag atg aca aaa gaa  gag ttc act agg tac  cgc aaa gag        7770
Leu Asn  Gln Met Thr Lys Glu  Glu Phe Thr Arg Tyr  Arg Lys Glu            
    2545                 2550                 2555                        

gcc atc  atc gaa gtc gat cgc  tca gcg gca aaa cac  gcc agg aaa        7815
Ala Ile  Ile Glu Val Asp Arg  Ser Ala Ala Lys His  Ala Arg Lys            
    2560                 2565                 2570                        

gaa ggc  aat gtc act gga ggg  cat cca gtc tct agg  ggc aca gca        7860
Glu Gly  Asn Val Thr Gly Gly  His Pro Val Ser Arg  Gly Thr Ala            
    2575                 2580                 2585                        

aaa ctg  aga tgg ctg gtc gaa  cgg agg ttt ctc gaa  ccg gtc gga        7905
Lys Leu  Arg Trp Leu Val Glu  Arg Arg Phe Leu Glu  Pro Val Gly            
    2590                 2595                 2600                        

aaa gtg  att gac ctt gga tgt  gga aga ggc ggt tgg  tgt tac tat        7950
Lys Val  Ile Asp Leu Gly Cys  Gly Arg Gly Gly Trp  Cys Tyr Tyr            
    2605                 2610                 2615                        

atg gca  acc caa aaa aga gtc  caa gaa gtc aga ggg  tac aca aag        7995
Met Ala  Thr Gln Lys Arg Val  Gln Glu Val Arg Gly  Tyr Thr Lys            
    2620                 2625                 2630                        

ggc ggt  ccc gga cat gaa gag  ccc caa cta gtg caa  agt tat gga        8040
Gly Gly  Pro Gly His Glu Glu  Pro Gln Leu Val Gln  Ser Tyr Gly            
    2635                 2640                 2645                        

tgg aac  att gtc acc atg aag  agt gga gtg gat gtg  ttc tac aga        8085
Trp Asn  Ile Val Thr Met Lys  Ser Gly Val Asp Val  Phe Tyr Arg            
    2650                 2655                 2660                        

cct tct  gag tgt tgt gac acc  ctc ctt tgt gac atc  gga gag tcc        8130
Pro Ser  Glu Cys Cys Asp Thr  Leu Leu Cys Asp Ile  Gly Glu Ser            
    2665                 2670                 2675                        

tcg tca  agt gct gag gtt gaa  gag cat agg acg att  cgg gtc ctt        8175
Ser Ser  Ser Ala Glu Val Glu  Glu His Arg Thr Ile  Arg Val Leu            
    2680                 2685                 2690                        

gaa atg  gtt gag gac tgg ctg  cac cga ggg cca agg  gaa ttt tgc        8220
Glu Met  Val Glu Asp Trp Leu  His Arg Gly Pro Arg  Glu Phe Cys            
    2695                 2700                 2705                        

gtg aag  gtg ctc tgc ccc tac  atg ccg aaa gtc ata  gag aag atg        8265
Val Lys  Val Leu Cys Pro Tyr  Met Pro Lys Val Ile  Glu Lys Met            
    2710                 2715                 2720                        

gag ctg  ctc caa cgc cgg tat  ggg ggg gga ctg gtc  aga aac cca        8310
Glu Leu  Leu Gln Arg Arg Tyr  Gly Gly Gly Leu Val  Arg Asn Pro            
    2725                 2730                 2735                        

ctc tca  cgg aat tcc acg cac  gag atg tat tgg gtg  agt cga gct        8355
Leu Ser  Arg Asn Ser Thr His  Glu Met Tyr Trp Val  Ser Arg Ala            
    2740                 2745                 2750                        

tca ggc  aat gtg gta cat tca  gtg aat atg acc agc  cag gtg ctc        8400
Ser Gly  Asn Val Val His Ser  Val Asn Met Thr Ser  Gln Val Leu            
    2755                 2760                 2765                        

cta gga  aga atg gaa aaa agg  acc tgg aag gga ccc  caa tac gag        8445
Leu Gly  Arg Met Glu Lys Arg  Thr Trp Lys Gly Pro  Gln Tyr Glu            
    2770                 2775                 2780                        

gaa gat  gta aac ttg gga agt  gga acc agg gcg gtg  gga aaa ccc        8490
Glu Asp  Val Asn Leu Gly Ser  Gly Thr Arg Ala Val  Gly Lys Pro            
    2785                 2790                 2795                        

ctg ctc  aac tca gac acc agt  aaa atc aag aac agg  att gaa cga        8535
Leu Leu  Asn Ser Asp Thr Ser  Lys Ile Lys Asn Arg  Ile Glu Arg            
    2800                 2805                 2810                        

ctc agg  cgt gag tac agt tcg  acg tgg cac cac gat  gag aac cac        8580
Leu Arg  Arg Glu Tyr Ser Ser  Thr Trp His His Asp  Glu Asn His            
    2815                 2820                 2825                        

cca tat  aga acc tgg aac tat  cac ggc agt tat gat  gtg aag ccc        8625
Pro Tyr  Arg Thr Trp Asn Tyr  His Gly Ser Tyr Asp  Val Lys Pro            
    2830                 2835                 2840                        

aca ggc  tcc gcc agt tcg ctg  gtc aat gga gtg gtc  agg ctc ctc        8670
Thr Gly  Ser Ala Ser Ser Leu  Val Asn Gly Val Val  Arg Leu Leu            
    2845                 2850                 2855                        

tca aaa  cca tgg gac acc atc  acg aat gtt acc acc  atg gcc atg        8715
Ser Lys  Pro Trp Asp Thr Ile  Thr Asn Val Thr Thr  Met Ala Met            
    2860                 2865                 2870                        

act gac  act act ccc ttc ggg  cag cag cga gtg ttc  aaa gag aag        8760
Thr Asp  Thr Thr Pro Phe Gly  Gln Gln Arg Val Phe  Lys Glu Lys            
    2875                 2880                 2885                        

gtg gac  acg aaa gct cct gaa  ccg cca gaa gga gtg  aag tac gtg        8805
Val Asp  Thr Lys Ala Pro Glu  Pro Pro Glu Gly Val  Lys Tyr Val            
    2890                 2895                 2900                        

ctc aac  gag acc acc aac tgg  ttg tgg gcg ttt ttg  gcc aga gaa        8850
Leu Asn  Glu Thr Thr Asn Trp  Leu Trp Ala Phe Leu  Ala Arg Glu            
    2905                 2910                 2915                        

aaa cgt  ccc aga atg tgc tct  cga gag gaa ttc ata  aga aag gtc        8895
Lys Arg  Pro Arg Met Cys Ser  Arg Glu Glu Phe Ile  Arg Lys Val            
    2920                 2925                 2930                        

aac agc  aat gca gct ttg ggt  gcc atg ttt gaa gag  cag aat caa        8940
Asn Ser  Asn Ala Ala Leu Gly  Ala Met Phe Glu Glu  Gln Asn Gln            
    2935                 2940                 2945                        

tgg agg  agc gcc aga gaa gca  gtt gaa gat cca aaa  ttt tgg gag        8985
Trp Arg  Ser Ala Arg Glu Ala  Val Glu Asp Pro Lys  Phe Trp Glu            
    2950                 2955                 2960                        

atg gtg  gat gag gag cgc gag  gca cat ctg cgg ggg  gaa tgt cac        9030
Met Val  Asp Glu Glu Arg Glu  Ala His Leu Arg Gly  Glu Cys His            
    2965                 2970                 2975                        

act tgc  att tac aac atg atg  gga aag aga gag aaa  aaa ccc gga        9075
Thr Cys  Ile Tyr Asn Met Met  Gly Lys Arg Glu Lys  Lys Pro Gly            
    2980                 2985                 2990                        

gag ttc  gga aag gcc aag gga  agc aga gcc att tgg  ttc atg tgg        9120
Glu Phe  Gly Lys Ala Lys Gly  Ser Arg Ala Ile Trp  Phe Met Trp            
    2995                 3000                 3005                        

ctc gga  gct cgc ttt ctg gag  ttc gag gct ctg ggt  ttt ctc aat        9165
Leu Gly  Ala Arg Phe Leu Glu  Phe Glu Ala Leu Gly  Phe Leu Asn            
    3010                 3015                 3020                        

gaa gac  cac tgg ctt gga aga  aag aac tca gga gga  ggt gtc gag        9210
Glu Asp  His Trp Leu Gly Arg  Lys Asn Ser Gly Gly  Gly Val Glu            
    3025                 3030                 3035                        

ggc ttg  ggc ctc caa aaa ctg  ggt tac atc ctg cgt  gaa gtt ggc        9255
Gly Leu  Gly Leu Gln Lys Leu  Gly Tyr Ile Leu Arg  Glu Val Gly            
    3040                 3045                 3050                        

acc cgg  cct ggg ggc aag atc  tat gct gat gac aca  gct ggc tgg        9300
Thr Arg  Pro Gly Gly Lys Ile  Tyr Ala Asp Asp Thr  Ala Gly Trp            
    3055                 3060                 3065                        

gac acc  cgc atc acg aga gct  gac ttg gaa aat gaa  gct aag gtg        9345
Asp Thr  Arg Ile Thr Arg Ala  Asp Leu Glu Asn Glu  Ala Lys Val            
    3070                 3075                 3080                        

ctt gag  ctg ctt gat ggg gaa  cat cgg cgt ctt gcc  agg gcc atc        9390
Leu Glu  Leu Leu Asp Gly Glu  His Arg Arg Leu Ala  Arg Ala Ile            
    3085                 3090                 3095                        

att gag  ctc acc tat cgt cac  aaa gtt gtg aaa gtg  atg cgc ccg        9435
Ile Glu  Leu Thr Tyr Arg His  Lys Val Val Lys Val  Met Arg Pro            
    3100                 3105                 3110                        

gct gct  gat gga aga acc gtc  atg gat gtt atc tcc  aga gaa gat        9480
Ala Ala  Asp Gly Arg Thr Val  Met Asp Val Ile Ser  Arg Glu Asp            
    3115                 3120                 3125                        

cag agg  ggg agt gga caa gtt  gtc acc tac gcc cta  aac act ttc        9525
Gln Arg  Gly Ser Gly Gln Val  Val Thr Tyr Ala Leu  Asn Thr Phe            
    3130                 3135                 3140                        

acc aac  ctg gcc gtc cag ctg  gtg agg atg atg gaa  ggg gaa gga        9570
Thr Asn  Leu Ala Val Gln Leu  Val Arg Met Met Glu  Gly Glu Gly            
    3145                 3150                 3155                        

gtg att  ggc cca gat gat gtg  gag aaa ctc aca aaa  ggg aaa gga        9615
Val Ile  Gly Pro Asp Asp Val  Glu Lys Leu Thr Lys  Gly Lys Gly            
    3160                 3165                 3170                        

ccc aaa  gtc agg acc tgg ctg  ttt gag aat ggg gaa  gaa aga ctc        9660
Pro Lys  Val Arg Thr Trp Leu  Phe Glu Asn Gly Glu  Glu Arg Leu            
    3175                 3180                 3185                        

agc cgc  atg gct gtc agt gga  gat gac tgt gtg gta  aag ccc ctg        9705
Ser Arg  Met Ala Val Ser Gly  Asp Asp Cys Val Val  Lys Pro Leu            
    3190                 3195                 3200                        

gac gat  cgc ttt gcc acc tcg  ctc cac ttc ctc aat  gct atg tca        9750
Asp Asp  Arg Phe Ala Thr Ser  Leu His Phe Leu Asn  Ala Met Ser            
    3205                 3210                 3215                        

aag gtt  cgc aaa gac atc caa  gag tgg aaa ccg tca  act gga tgg        9795
Lys Val  Arg Lys Asp Ile Gln  Glu Trp Lys Pro Ser  Thr Gly Trp            
    3220                 3225                 3230                        

tat gat  tgg cag cag gtt cca  ttt tgc tca aac cat  ttc act gaa        9840
Tyr Asp  Trp Gln Gln Val Pro  Phe Cys Ser Asn His  Phe Thr Glu            
    3235                 3240                 3245                        

ttg atc  atg aaa gat gga aga  aca ctg gtg gtt cca  tgc cga gga        9885
Leu Ile  Met Lys Asp Gly Arg  Thr Leu Val Val Pro  Cys Arg Gly            
    3250                 3255                 3260                        

cag gat  gaa ttg gta ggc aga  gct cgc ata tct cca  ggg gcc gga        9930
Gln Asp  Glu Leu Val Gly Arg  Ala Arg Ile Ser Pro  Gly Ala Gly            
    3265                 3270                 3275                        

tgg aac  gtc cgc gac act gct  tgt ctg gct aag tct  tat gcc cag        9975
Trp Asn  Val Arg Asp Thr Ala  Cys Leu Ala Lys Ser  Tyr Ala Gln            
    3280                 3285                 3290                        

atg tgg  ctg ctt ctg tac ttc  cac aga aga gac ctg  cgg ctc atg       10020
Met Trp  Leu Leu Leu Tyr Phe  His Arg Arg Asp Leu  Arg Leu Met            
    3295                 3300                 3305                        

gcc aac  gcc att tgc tcc gct  gtc cct gtg aat tgg  gtc cct acc       10065
Ala Asn  Ala Ile Cys Ser Ala  Val Pro Val Asn Trp  Val Pro Thr            
    3310                 3315                 3320                        

gga aga  acc acg tgg tcc atc  cat gca gga gga gag  tgg atg aca       10110
Gly Arg  Thr Thr Trp Ser Ile  His Ala Gly Gly Glu  Trp Met Thr            
    3325                 3330                 3335                        

aca gag  gac atg ttg gag gtc  tgg aac cgt gtt tgg  ata gag gag       10155
Thr Glu  Asp Met Leu Glu Val  Trp Asn Arg Val Trp  Ile Glu Glu            
    3340                 3345                 3350                        

aat gaa  tgg atg gaa gac aaa  acc cca gtg gag aaa  tgg agt gac       10200
Asn Glu  Trp Met Glu Asp Lys  Thr Pro Val Glu Lys  Trp Ser Asp            
    3355                 3360                 3365                        

gtc cca  tat tca gga aaa cga  gag gac atc tgg tgt  ggc agc ctg       10245
Val Pro  Tyr Ser Gly Lys Arg  Glu Asp Ile Trp Cys  Gly Ser Leu            
    3370                 3375                 3380                        

att ggc  aca aga gcc cga gcc  acg tgg gca gaa aac  atc cag gtg       10290
Ile Gly  Thr Arg Ala Arg Ala  Thr Trp Ala Glu Asn  Ile Gln Val            
    3385                 3390                 3395                        

gct atc  aac caa gtc aga gca  atc atc gga gat gag  aag tat gtg       10335
Ala Ile  Asn Gln Val Arg Ala  Ile Ile Gly Asp Glu  Lys Tyr Val            
    3400                 3405                 3410                        

gat tac  atg agt tca cta aag  aga tat gaa gac aca  act ttg gtt       10380
Asp Tyr  Met Ser Ser Leu Lys  Arg Tyr Glu Asp Thr  Thr Leu Val            
    3415                 3420                 3425                        

gag gac  aca gta ctg tag atatttaatc aattgtaaat agacaatata            10428
Glu Asp  Thr Val Leu                                                      
    3430                                                                  

agtatgcata aaagtgtagt tttatagtag tatttagtgg tgttagtgta aatagttaag    10488

aaaattttga ggagaaagtc aggccgggaa gttcccgcca ccggaagttg agtagacggt    10548

gctgcctgcg actcaacccc aggaggactg ggtgaacaaa gccgcgaagt gatccatgta    10608

agccctcaga accgtctcgg aaggaggacc ccacatgttg taacttcaaa gcccaatgtc    10668

agaccacgct acggcgtgct actctgcgga gagtgcagtc tgcgatagtg ccccaggagg    10728

actgggttaa caaaggcaaa ccaacgcccc acgcggccct agccccggta atggtgttaa    10788

ccagggcgaa aggactagag gttagaggag accccgcggt ttaaagtgca cggcccagcc    10848

tggctgaagc tgtaggtcag gggaaggact agaggttagt ggagaccccg tgccacaaaa    10908

caccacaaca aaacagcata ttgacacctg ggatagacta ggagatcttc tgctctgcac    10968

aaccagccac acggcacagt gcgccgacaa tggtggctgg tggtgcgaga acacaggatc    11028

t                                                                    11029


<210>  2
<211>  3433
<212>  PRT
<213>  West Nile virus

<400>  2

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala 
            100                 105                 110         


Val Met Ile Gly Leu Ile Ala Ser Val Gly Ala Val Thr Leu Ser Asn 
        115                 120                 125             


Phe Gln Gly Lys Val Met Met Thr Val Asn Ala Thr Asp Val Thr Asp 
    130                 135                 140                 


Val Ile Thr Ile Pro Thr Ala Ala Gly Lys Asn Leu Cys Ile Val Arg 
145                 150                 155                 160 


Ala Met Asp Val Gly Tyr Met Cys Asp Asp Thr Ile Thr Tyr Glu Cys 
                165                 170                 175     


Pro Val Leu Ser Ala Gly Asn Asp Pro Glu Asp Ile Asp Cys Trp Cys 
            180                 185                 190         


Thr Lys Ser Ala Val Tyr Val Arg Tyr Gly Arg Cys Thr Lys Thr Arg 
        195                 200                 205             


His Ser Arg Arg Ser Arg Arg Ser Leu Thr Val Gln Thr His Gly Glu 
    210                 215                 220                 


Ser Thr Leu Ala Asn Lys Lys Gly Ala Trp Met Asp Ser Thr Lys Ala 
225                 230                 235                 240 


Thr Arg Tyr Leu Val Lys Thr Glu Ser Trp Ile Leu Arg Asn Pro Gly 
                245                 250                 255     


Tyr Ala Leu Val Ala Ala Val Ile Gly Trp Met Leu Gly Ser Asn Thr 
            260                 265                 270         


Met Gln Arg Val Val Phe Val Val Leu Leu Leu Leu Val Ala Pro Ala 
        275                 280                 285             


Tyr Ser Phe Asn Cys Leu Gly Met Ser Asn Arg Asp Phe Leu Glu Gly 
    290                 295                 300                 


Val Ser Gly Ala Thr Trp Val Asp Leu Val Leu Glu Gly Asp Ser Cys 
305                 310                 315                 320 


Val Thr Ile Met Ser Lys Asp Lys Pro Thr Ile Asp Val Lys Met Met 
                325                 330                 335     


Asn Met Glu Ala Ala Asn Leu Ala Glu Val Arg Ser Tyr Cys Tyr Leu 
            340                 345                 350         


Ala Thr Val Ser Asp Leu Ser Thr Lys Ala Ala Cys Pro Thr Met Gly 
        355                 360                 365             


Glu Ala His Asn Asp Lys Arg Ala Asp Pro Ala Phe Val Cys Arg Gln 
    370                 375                 380                 


Gly Val Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Ile Asp Thr Cys Ala Lys Phe Ala Cys Ser Thr Lys Ala Ile 
                405                 410                 415     


Gly Arg Thr Ile Leu Lys Glu Asn Ile Lys Tyr Glu Val Ala Ile Phe 
            420                 425                 430         


Val His Gly Pro Thr Thr Val Glu Ser His Gly Asn Tyr Ser Thr Gln 
        435                 440                 445             


Val Gly Ala Thr Gln Ala Gly Arg Phe Ser Ile Thr Pro Ala Ala Pro 
    450                 455                 460                 


Ser Tyr Thr Leu Lys Leu Gly Glu Tyr Gly Glu Val Thr Val Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Ser Gly Ile Asp Thr Asn Ala Tyr Tyr Val Met Thr Val 
                485                 490                 495     


Gly Thr Lys Thr Phe Leu Val His Arg Glu Trp Phe Met Asp Leu Asn 
            500                 505                 510         


Leu Pro Trp Ser Ser Ala Gly Ser Thr Val Trp Arg Asn Arg Glu Thr 
        515                 520                 525             


Leu Met Glu Phe Glu Glu Pro His Ala Thr Lys Gln Ser Val Ile Ala 
    530                 535                 540                 


Leu Gly Ser Gln Glu Gly Ala Leu His Gln Ala Leu Ala Gly Ala Ile 
545                 550                 555                 560 


Pro Val Glu Phe Ser Ser Asn Thr Val Lys Leu Thr Ser Gly His Leu 
                565                 570                 575     


Lys Cys Arg Val Lys Met Glu Lys Leu Gln Leu Lys Gly Thr Thr Tyr 
            580                 585                 590         


Gly Val Cys Ser Lys Ala Phe Lys Phe Leu Gly Thr Pro Ala Asp Thr 
        595                 600                 605             


Gly His Gly Thr Val Val Leu Glu Leu Gln Tyr Thr Gly Thr Asp Gly 
    610                 615                 620                 


Pro Cys Lys Val Pro Ile Ser Ser Val Ala Ser Leu Asn Asp Leu Thr 
625                 630                 635                 640 


Pro Val Gly Arg Leu Val Thr Val Asn Pro Phe Val Ser Val Ala Thr 
                645                 650                 655     


Ala Asn Ala Lys Val Leu Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser 
            660                 665                 670         


Tyr Ile Val Val Gly Arg Gly Glu Gln Gln Ile Asn His His Trp His 
        675                 680                 685             


Lys Ser Gly Ser Ser Ile Gly Lys Ala Phe Thr Thr Thr Leu Lys Gly 
    690                 695                 700                 


Ala Gln Arg Leu Ala Ala Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser 
705                 710                 715                 720 


Val Gly Gly Val Phe Thr Ser Val Gly Lys Ala Val His Gln Val Phe 
                725                 730                 735     


Gly Gly Ala Phe Arg Ser Leu Phe Gly Gly Met Ser Trp Ile Thr Gln 
            740                 745                 750         


Gly Leu Leu Gly Ala Leu Leu Leu Trp Met Gly Ile Asn Ala Arg Asp 
        755                 760                 765             


Arg Ser Ile Ala Leu Thr Phe Leu Ala Val Gly Gly Val Leu Leu Phe 
    770                 775                 780                 


Leu Ser Val Asn Val His Ala Asp Thr Gly Cys Ala Ile Asp Ile Ser 
785                 790                 795                 800 


Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile His Asn Asp Val 
                805                 810                 815     


Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu Thr Pro Gln Gly 
            820                 825                 830         


Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly Val Cys Gly Leu 
        835                 840                 845             


Arg Ser Val Ser Arg Leu Glu His Gln Met Trp Glu Ala Val Lys Asp 
    850                 855                 860                 


Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp Leu Ser Val Val 
865                 870                 875                 880 


Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro Lys Arg Leu Thr 
                885                 890                 895     


Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala Trp Gly Lys Ser 
            900                 905                 910         


Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe Val Val Asp Gly 
        915                 920                 925             


Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala Trp Asn Ser Leu 
    930                 935                 940                 


Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr Arg Met Phe Leu 
945                 950                 955                 960 


Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser Lys Ile Ile Gly 
                965                 970                 975     


Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp Leu Ser Tyr Trp 
            980                 985                 990         


Ile Glu Ser Arg Leu Asn Asp Thr  Trp Lys Leu Glu Arg  Ala Val Leu 
        995                 1000                 1005             


Gly Glu  Val Lys Ser Cys Thr  Trp Pro Glu Thr His  Thr Leu Trp 
    1010                 1015                 1020             


Gly Asp  Gly Ile Leu Glu Ser  Asp Leu Ile Ile Pro  Val Thr Leu 
    1025                 1030                 1035             


Ala Gly  Pro Arg Ser Asn His  Asn Arg Arg Pro Gly  Tyr Lys Thr 
    1040                 1045                 1050             


Gln Asn  Gln Gly Pro Trp Asp  Glu Gly Arg Val Glu  Ile Asp Phe 
    1055                 1060                 1065             


Asp Tyr  Cys Pro Gly Thr Thr  Val Thr Leu Ser Glu  Ser Cys Gly 
    1070                 1075                 1080             


His Arg  Gly Pro Ala Thr Arg  Thr Thr Thr Glu Ser  Gly Lys Leu 
    1085                 1090                 1095             


Ile Thr  Asp Trp Cys Cys Arg  Ser Cys Thr Leu Pro  Pro Leu Arg 
    1100                 1105                 1110             


Tyr Gln  Thr Asp Ser Gly Cys  Trp Tyr Gly Met Glu  Ile Arg Pro 
    1115                 1120                 1125             


Gln Arg  His Asp Glu Lys Thr  Leu Val Gln Ser Gln  Val Asn Ala 
    1130                 1135                 1140             


Tyr Asn  Ala Asp Met Ile Asp  Pro Phe Gln Leu Gly  Leu Leu Val 
    1145                 1150                 1155             


Val Phe  Leu Ala Thr Gln Glu  Val Leu Arg Lys Arg  Trp Thr Ala 
    1160                 1165                 1170             


Lys Ile  Ser Met Pro Ala Ile  Leu Ile Ala Leu Leu  Val Leu Val 
    1175                 1180                 1185             


Phe Gly  Gly Ile Thr Tyr Thr  Asp Val Leu Arg Tyr  Val Ile Leu 
    1190                 1195                 1200             


Val Gly  Ala Ala Phe Ala Glu  Ser Asn Ser Gly Gly  Asp Val Val 
    1205                 1210                 1215             


His Leu  Ala Leu Met Ala Thr  Phe Lys Ile Gln Pro  Val Phe Met 
    1220                 1225                 1230             


Val Ala  Ser Phe Leu Lys Ala  Arg Trp Thr Asn Gln  Glu Asn Ile 
    1235                 1240                 1245             


Leu Leu  Met Leu Ala Ala Val  Phe Phe Gln Met Ala  Tyr Tyr Asp 
    1250                 1255                 1260             


Ala Arg  Gln Ile Leu Leu Trp  Glu Ile Pro Asp Val  Leu Asn Ser 
    1265                 1270                 1275             


Leu Ala  Val Ala Trp Met Ile  Leu Arg Ala Ile Thr  Phe Thr Thr 
    1280                 1285                 1290             


Thr Ser  Asn Val Val Val Pro  Leu Leu Ala Leu Leu  Thr Pro Gly 
    1295                 1300                 1305             


Leu Arg  Cys Leu Asn Leu Asp  Val Tyr Arg Ile Leu  Leu Leu Met 
    1310                 1315                 1320             


Val Gly  Ile Gly Ser Leu Ile  Arg Glu Lys Arg Ser  Ala Ala Ala 
    1325                 1330                 1335             


Lys Lys  Lys Gly Ala Ser Leu  Leu Cys Leu Ala Leu  Ala Ser Thr 
    1340                 1345                 1350             


Gly Leu  Phe Asn Pro Met Ile  Leu Ala Ala Gly Leu  Ile Ala Cys 
    1355                 1360                 1365             


Asp Pro  Asn Arg Lys Arg Gly  Trp Pro Ala Thr Glu  Val Met Thr 
    1370                 1375                 1380             


Ala Val  Gly Leu Met Phe Ala  Ile Val Gly Gly Leu  Ala Glu Leu 
    1385                 1390                 1395             


Asp Ile  Asp Ser Met Ala Ile  Pro Met Thr Ile Ala  Gly Leu Met 
    1400                 1405                 1410             


Phe Ala  Ala Phe Val Ile Ser  Gly Lys Ser Thr Asp  Met Trp Ile 
    1415                 1420                 1425             


Glu Arg  Thr Ala Asp Ile Ser  Trp Glu Ser Asp Ala  Glu Ile Thr 
    1430                 1435                 1440             


Gly Ser  Ser Glu Arg Val Asp  Val Arg Leu Asp Asp  Asp Gly Asn 
    1445                 1450                 1455             


Phe Gln  Leu Met Asn Asp Pro  Gly Ala Pro Trp Lys  Ile Trp Met 
    1460                 1465                 1470             


Leu Arg  Met Val Cys Leu Ala  Ile Ser Ala Tyr Thr  Pro Trp Ala 
    1475                 1480                 1485             


Ile Leu  Pro Ser Val Val Gly  Phe Trp Ile Thr Leu  Gln Tyr Thr 
    1490                 1495                 1500             


Lys Arg  Gly Gly Val Leu Trp  Asp Thr Pro Ser Pro  Lys Glu Tyr 
    1505                 1510                 1515             


Lys Lys  Gly Asp Thr Thr Thr  Gly Val Tyr Arg Ile  Met Thr Arg 
    1520                 1525                 1530             


Gly Leu  Leu Gly Ser Tyr Gln  Ala Gly Ala Gly Val  Met Val Glu 
    1535                 1540                 1545             


Gly Val  Phe His Thr Leu Trp  His Thr Thr Lys Gly  Ala Ala Leu 
    1550                 1555                 1560             


Met Ser  Gly Glu Gly Arg Leu  Asp Pro Tyr Trp Gly  Ser Val Lys 
    1565                 1570                 1575             


Glu Asp  Arg Leu Cys Tyr Gly  Gly Pro Trp Lys Leu  Gln His Lys 
    1580                 1585                 1590             


Trp Asn  Gly Gln Asp Glu Val  Gln Met Ile Val Val  Glu Pro Gly 
    1595                 1600                 1605             


Arg Asn  Val Lys Asn Val Gln  Thr Lys Pro Gly Val  Phe Lys Thr 
    1610                 1615                 1620             


Pro Glu  Gly Glu Ile Gly Ala  Val Thr Leu Asp Phe  Pro Thr Gly 
    1625                 1630                 1635             


Thr Ser  Gly Ser Pro Ile Val  Asp Lys Asn Gly Asp  Val Ile Gly 
    1640                 1645                 1650             


Leu Tyr  Gly Asn Gly Val Ile  Met Pro Asn Gly Ser  Tyr Ile Ser 
    1655                 1660                 1665             


Ala Ile  Val Gln Gly Glu Arg  Met Asp Glu Pro Ile  Pro Ala Gly 
    1670                 1675                 1680             


Phe Glu  Pro Glu Met Leu Arg  Lys Lys Gln Ile Thr  Val Leu Asp 
    1685                 1690                 1695             


Leu His  Pro Gly Ala Gly Lys  Thr Arg Arg Ile Leu  Pro Gln Ile 
    1700                 1705                 1710             


Ile Lys  Glu Ala Ile Asn Arg  Arg Leu Arg Thr Ala  Val Leu Ala 
    1715                 1720                 1725             


Pro Thr  Arg Val Val Ala Ala  Glu Met Ala Glu Ala  Leu Arg Gly 
    1730                 1735                 1740             


Leu Pro  Ile Arg Tyr Gln Thr  Ser Ala Val Pro Arg  Glu His Asn 
    1745                 1750                 1755             


Gly Asn  Glu Ile Val Asp Val  Met Cys His Ala Thr  Leu Thr His 
    1760                 1765                 1770             


Arg Leu  Met Ser Pro His Arg  Val Pro Asn Tyr Asn  Leu Phe Val 
    1775                 1780                 1785             


Met Asp  Glu Ala His Phe Thr  Asp Pro Ala Ser Ile  Ala Ala Arg 
    1790                 1795                 1800             


Gly Tyr  Ile Ser Thr Lys Val  Glu Leu Gly Glu Ala  Ala Ala Ile 
    1805                 1810                 1815             


Phe Met  Thr Ala Thr Pro Pro  Gly Thr Ser Asp Pro  Phe Pro Glu 
    1820                 1825                 1830             


Ser Asn  Ser Pro Ile Ser Asp  Leu Gln Thr Glu Ile  Pro Asp Arg 
    1835                 1840                 1845             


Ala Trp  Asn Ser Gly Tyr Glu  Trp Ile Thr Glu Tyr  Thr Gly Lys 
    1850                 1855                 1860             


Thr Val  Trp Phe Val Pro Ser  Val Lys Met Gly Asn  Glu Ile Ala 
    1865                 1870                 1875             


Leu Cys  Leu Gln Arg Ala Gly  Lys Lys Val Val Gln  Leu Asn Arg 
    1880                 1885                 1890             


Lys Ser  Tyr Glu Thr Glu Tyr  Pro Lys Cys Lys Asn  Asp Asp Trp 
    1895                 1900                 1905             


Asp Phe  Val Ile Thr Thr Asp  Ile Ser Glu Met Gly  Ala Asn Phe 
    1910                 1915                 1920             


Lys Ala  Ser Arg Val Ile Asp  Ser Arg Lys Ser Val  Lys Pro Thr 
    1925                 1930                 1935             


Ile Ile  Thr Glu Gly Glu Gly  Arg Val Ile Leu Gly  Glu Pro Ser 
    1940                 1945                 1950             


Ala Val  Thr Ala Ala Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly 
    1955                 1960                 1965             


Arg Asn  Pro Ser Gln Val Gly  Asp Glu Tyr Cys Tyr  Gly Gly His 
    1970                 1975                 1980             


Thr Asn  Glu Asp Asp Ser Asn  Phe Ala His Trp Thr  Glu Ala Arg 
    1985                 1990                 1995             


Ile Met  Leu Asp Asn Ile Asn  Met Pro Asn Gly Leu  Ile Ala Gln 
    2000                 2005                 2010             


Phe Tyr  Gln Pro Glu Arg Glu  Lys Val Tyr Thr Met  Asp Gly Glu 
    2015                 2020                 2025             


Tyr Arg  Leu Arg Gly Glu Glu  Arg Lys Asn Phe Leu  Glu Leu Leu 
    2030                 2035                 2040             


Arg Thr  Ala Asp Leu Pro Val  Trp Leu Ala Tyr Lys  Val Ala Ala 
    2045                 2050                 2055             


Ala Gly  Val Ser Tyr His Asp  Arg Arg Trp Cys Phe  Asp Gly Pro 
    2060                 2065                 2070             


Arg Thr  Asn Thr Ile Leu Glu  Asp Asn Asn Glu Val  Glu Val Ile 
    2075                 2080                 2085             


Thr Lys  Leu Gly Glu Arg Lys  Ile Leu Arg Pro Arg  Trp Ile Asp 
    2090                 2095                 2100             


Ala Arg  Val Tyr Ser Asp His  Gln Ala Leu Lys Ala  Phe Lys Asp 
    2105                 2110                 2115             


Phe Ala  Ser Gly Lys Arg Ser  Gln Ile Gly Leu Ile  Glu Val Leu 
    2120                 2125                 2130             


Gly Lys  Met Pro Glu His Phe  Met Gly Lys Thr Trp  Glu Ala Leu 
    2135                 2140                 2145             


Asp Thr  Met Tyr Val Val Ala  Thr Ala Glu Lys Gly  Gly Arg Ala 
    2150                 2155                 2160             


His Arg  Met Ala Leu Glu Glu  Leu Pro Asp Ala Leu  Gln Thr Ile 
    2165                 2170                 2175             


Ala Leu  Ile Ala Leu Leu Ser  Val Met Thr Met Gly  Val Phe Phe 
    2180                 2185                 2190             


Leu Leu  Met Gln Arg Lys Gly  Ile Gly Lys Ile Gly  Leu Gly Gly 
    2195                 2200                 2205             


Ala Val  Leu Gly Val Ala Thr  Phe Phe Cys Trp Met  Ala Glu Val 
    2210                 2215                 2220             


Pro Gly  Thr Lys Ile Ala Gly  Met Leu Leu Leu Ser  Leu Leu Leu 
    2225                 2230                 2235             


Met Ile  Val Leu Ile Pro Glu  Pro Glu Lys Gln Arg  Ser Gln Thr 
    2240                 2245                 2250             


Asp Asn  Gln Leu Ala Val Phe  Leu Ile Cys Val Met  Thr Leu Val 
    2255                 2260                 2265             


Ser Ala  Val Ala Ala Asn Glu  Met Gly Trp Leu Asp  Lys Thr Lys 
    2270                 2275                 2280             


Ser Asp  Ile Ser Ser Leu Phe  Gly Gln Arg Ile Glu  Val Lys Glu 
    2285                 2290                 2295             


Asn Phe  Ser Met Gly Glu Phe  Leu Leu Asp Leu Arg  Pro Ala Thr 
    2300                 2305                 2310             


Ala Trp  Ser Leu Tyr Ala Val  Thr Thr Ala Val Leu  Thr Pro Leu 
    2315                 2320                 2325             


Leu Lys  His Leu Ile Thr Ser  Asp Tyr Ile Asn Thr  Ser Leu Thr 
    2330                 2335                 2340             


Ser Ile  Asn Val Gln Ala Ser  Ala Leu Phe Thr Leu  Ala Arg Gly 
    2345                 2350                 2355             


Phe Pro  Phe Val Asp Val Gly  Val Ser Ala Leu Leu  Leu Ala Ala 
    2360                 2365                 2370             


Gly Cys  Trp Gly Gln Val Thr  Leu Thr Val Thr Val  Thr Ala Ala 
    2375                 2380                 2385             


Thr Leu  Leu Phe Cys His Tyr  Ala Tyr Met Val Pro  Gly Trp Gln 
    2390                 2395                 2400             


Ala Glu  Ala Met Arg Ser Ala  Gln Arg Arg Thr Ala  Ala Gly Ile 
    2405                 2410                 2415             


Met Lys  Asn Ala Val Val Asp  Gly Ile Val Ala Thr  Asp Val Pro 
    2420                 2425                 2430             


Glu Leu  Glu Arg Thr Thr Pro  Ile Met Gln Lys Lys  Val Gly Gln 
    2435                 2440                 2445             


Ile Met  Leu Ile Leu Val Ser  Leu Ala Ala Val Val  Val Asn Pro 
    2450                 2455                 2460             


Ser Val  Lys Thr Val Arg Glu  Ala Gly Ile Leu Ile  Thr Ala Ala 
    2465                 2470                 2475             


Ala Val  Thr Leu Trp Glu Asn  Gly Ala Ser Ser Val  Trp Asn Ala 
    2480                 2485                 2490             


Thr Thr  Ala Ile Gly Leu Cys  His Ile Met Arg Gly  Gly Trp Leu 
    2495                 2500                 2505             


Ser Cys  Leu Ser Ile Thr Trp  Thr Leu Ile Lys Asn  Met Glu Lys 
    2510                 2515                 2520             


Pro Gly  Leu Lys Arg Gly Gly  Ala Lys Gly Arg Thr  Leu Gly Glu 
    2525                 2530                 2535             


Val Trp  Lys Glu Arg Leu Asn  Gln Met Thr Lys Glu  Glu Phe Thr 
    2540                 2545                 2550             


Arg Tyr  Arg Lys Glu Ala Ile  Ile Glu Val Asp Arg  Ser Ala Ala 
    2555                 2560                 2565             


Lys His  Ala Arg Lys Glu Gly  Asn Val Thr Gly Gly  His Pro Val 
    2570                 2575                 2580             


Ser Arg  Gly Thr Ala Lys Leu  Arg Trp Leu Val Glu  Arg Arg Phe 
    2585                 2590                 2595             


Leu Glu  Pro Val Gly Lys Val  Ile Asp Leu Gly Cys  Gly Arg Gly 
    2600                 2605                 2610             


Gly Trp  Cys Tyr Tyr Met Ala  Thr Gln Lys Arg Val  Gln Glu Val 
    2615                 2620                 2625             


Arg Gly  Tyr Thr Lys Gly Gly  Pro Gly His Glu Glu  Pro Gln Leu 
    2630                 2635                 2640             


Val Gln  Ser Tyr Gly Trp Asn  Ile Val Thr Met Lys  Ser Gly Val 
    2645                 2650                 2655             


Asp Val  Phe Tyr Arg Pro Ser  Glu Cys Cys Asp Thr  Leu Leu Cys 
    2660                 2665                 2670             


Asp Ile  Gly Glu Ser Ser Ser  Ser Ala Glu Val Glu  Glu His Arg 
    2675                 2680                 2685             


Thr Ile  Arg Val Leu Glu Met  Val Glu Asp Trp Leu  His Arg Gly 
    2690                 2695                 2700             


Pro Arg  Glu Phe Cys Val Lys  Val Leu Cys Pro Tyr  Met Pro Lys 
    2705                 2710                 2715             


Val Ile  Glu Lys Met Glu Leu  Leu Gln Arg Arg Tyr  Gly Gly Gly 
    2720                 2725                 2730             


Leu Val  Arg Asn Pro Leu Ser  Arg Asn Ser Thr His  Glu Met Tyr 
    2735                 2740                 2745             


Trp Val  Ser Arg Ala Ser Gly  Asn Val Val His Ser  Val Asn Met 
    2750                 2755                 2760             


Thr Ser  Gln Val Leu Leu Gly  Arg Met Glu Lys Arg  Thr Trp Lys 
    2765                 2770                 2775             


Gly Pro  Gln Tyr Glu Glu Asp  Val Asn Leu Gly Ser  Gly Thr Arg 
    2780                 2785                 2790             


Ala Val  Gly Lys Pro Leu Leu  Asn Ser Asp Thr Ser  Lys Ile Lys 
    2795                 2800                 2805             


Asn Arg  Ile Glu Arg Leu Arg  Arg Glu Tyr Ser Ser  Thr Trp His 
    2810                 2815                 2820             


His Asp  Glu Asn His Pro Tyr  Arg Thr Trp Asn Tyr  His Gly Ser 
    2825                 2830                 2835             


Tyr Asp  Val Lys Pro Thr Gly  Ser Ala Ser Ser Leu  Val Asn Gly 
    2840                 2845                 2850             


Val Val  Arg Leu Leu Ser Lys  Pro Trp Asp Thr Ile  Thr Asn Val 
    2855                 2860                 2865             


Thr Thr  Met Ala Met Thr Asp  Thr Thr Pro Phe Gly  Gln Gln Arg 
    2870                 2875                 2880             


Val Phe  Lys Glu Lys Val Asp  Thr Lys Ala Pro Glu  Pro Pro Glu 
    2885                 2890                 2895             


Gly Val  Lys Tyr Val Leu Asn  Glu Thr Thr Asn Trp  Leu Trp Ala 
    2900                 2905                 2910             


Phe Leu  Ala Arg Glu Lys Arg  Pro Arg Met Cys Ser  Arg Glu Glu 
    2915                 2920                 2925             


Phe Ile  Arg Lys Val Asn Ser  Asn Ala Ala Leu Gly  Ala Met Phe 
    2930                 2935                 2940             


Glu Glu  Gln Asn Gln Trp Arg  Ser Ala Arg Glu Ala  Val Glu Asp 
    2945                 2950                 2955             


Pro Lys  Phe Trp Glu Met Val  Asp Glu Glu Arg Glu  Ala His Leu 
    2960                 2965                 2970             


Arg Gly  Glu Cys His Thr Cys  Ile Tyr Asn Met Met  Gly Lys Arg 
    2975                 2980                 2985             


Glu Lys  Lys Pro Gly Glu Phe  Gly Lys Ala Lys Gly  Ser Arg Ala 
    2990                 2995                 3000             


Ile Trp  Phe Met Trp Leu Gly  Ala Arg Phe Leu Glu  Phe Glu Ala 
    3005                 3010                 3015             


Leu Gly  Phe Leu Asn Glu Asp  His Trp Leu Gly Arg  Lys Asn Ser 
    3020                 3025                 3030             


Gly Gly  Gly Val Glu Gly Leu  Gly Leu Gln Lys Leu  Gly Tyr Ile 
    3035                 3040                 3045             


Leu Arg  Glu Val Gly Thr Arg  Pro Gly Gly Lys Ile  Tyr Ala Asp 
    3050                 3055                 3060             


Asp Thr  Ala Gly Trp Asp Thr  Arg Ile Thr Arg Ala  Asp Leu Glu 
    3065                 3070                 3075             


Asn Glu  Ala Lys Val Leu Glu  Leu Leu Asp Gly Glu  His Arg Arg 
    3080                 3085                 3090             


Leu Ala  Arg Ala Ile Ile Glu  Leu Thr Tyr Arg His  Lys Val Val 
    3095                 3100                 3105             


Lys Val  Met Arg Pro Ala Ala  Asp Gly Arg Thr Val  Met Asp Val 
    3110                 3115                 3120             


Ile Ser  Arg Glu Asp Gln Arg  Gly Ser Gly Gln Val  Val Thr Tyr 
    3125                 3130                 3135             


Ala Leu  Asn Thr Phe Thr Asn  Leu Ala Val Gln Leu  Val Arg Met 
    3140                 3145                 3150             


Met Glu  Gly Glu Gly Val Ile  Gly Pro Asp Asp Val  Glu Lys Leu 
    3155                 3160                 3165             


Thr Lys  Gly Lys Gly Pro Lys  Val Arg Thr Trp Leu  Phe Glu Asn 
    3170                 3175                 3180             


Gly Glu  Glu Arg Leu Ser Arg  Met Ala Val Ser Gly  Asp Asp Cys 
    3185                 3190                 3195             


Val Val  Lys Pro Leu Asp Asp  Arg Phe Ala Thr Ser  Leu His Phe 
    3200                 3205                 3210             


Leu Asn  Ala Met Ser Lys Val  Arg Lys Asp Ile Gln  Glu Trp Lys 
    3215                 3220                 3225             


Pro Ser  Thr Gly Trp Tyr Asp  Trp Gln Gln Val Pro  Phe Cys Ser 
    3230                 3235                 3240             


Asn His  Phe Thr Glu Leu Ile  Met Lys Asp Gly Arg  Thr Leu Val 
    3245                 3250                 3255             


Val Pro  Cys Arg Gly Gln Asp  Glu Leu Val Gly Arg  Ala Arg Ile 
    3260                 3265                 3270             


Ser Pro  Gly Ala Gly Trp Asn  Val Arg Asp Thr Ala  Cys Leu Ala 
    3275                 3280                 3285             


Lys Ser  Tyr Ala Gln Met Trp  Leu Leu Leu Tyr Phe  His Arg Arg 
    3290                 3295                 3300             


Asp Leu  Arg Leu Met Ala Asn  Ala Ile Cys Ser Ala  Val Pro Val 
    3305                 3310                 3315             


Asn Trp  Val Pro Thr Gly Arg  Thr Thr Trp Ser Ile  His Ala Gly 
    3320                 3325                 3330             


Gly Glu  Trp Met Thr Thr Glu  Asp Met Leu Glu Val  Trp Asn Arg 
    3335                 3340                 3345             


Val Trp  Ile Glu Glu Asn Glu  Trp Met Glu Asp Lys  Thr Pro Val 
    3350                 3355                 3360             


Glu Lys  Trp Ser Asp Val Pro  Tyr Ser Gly Lys Arg  Glu Asp Ile 
    3365                 3370                 3375             


Trp Cys  Gly Ser Leu Ile Gly  Thr Arg Ala Arg Ala  Thr Trp Ala 
    3380                 3385                 3390             


Glu Asn  Ile Gln Val Ala Ile  Asn Gln Val Arg Ala  Ile Ile Gly 
    3395                 3400                 3405             


Asp Glu  Lys Tyr Val Asp Tyr  Met Ser Ser Leu Lys  Arg Tyr Glu 
    3410                 3415                 3420             


Asp Thr  Thr Leu Val Glu Asp  Thr Val Leu 
    3425                 3430             


<210>  3
<211>  10735
<212>  DNA
<213>  Dengue virus type 1


<220>
<221>  CDS
<222>  (95)..(10273)

<400>  3
agttgttagt ctacgtggac cgacaagaac agtttcgaat cggaagcttg cttaacgtag       60

ttctaacagt tttttattag agagcagatc tctg atg atc aac caa cga aaa aag      115
                                      Met Ile Asn Gln Arg Lys Lys         
                                      1               5                   

acg ggt cga ccg tct ttc aat atg ctg aaa cgc gcg aga aac cgc gtg        163
Thr Gly Arg Pro Ser Phe Asn Met Leu Lys Arg Ala Arg Asn Arg Val           
        10                  15                  20                        

tca act gtt tca cag ttg gcg aag aga ttc tca aaa gga ttg ctc tca        211
Ser Thr Val Ser Gln Leu Ala Lys Arg Phe Ser Lys Gly Leu Leu Ser           
    25                  30                  35                            

ggc caa gga ccc atg aaa ttg gtg atg gct ttc ata gca ttc tta aga        259
Gly Gln Gly Pro Met Lys Leu Val Met Ala Phe Ile Ala Phe Leu Arg           
40                  45                  50                  55            

ttt cta gcc ata ccc cca aca gca gga att ttg gct aga tgg ggc tca        307
Phe Leu Ala Ile Pro Pro Thr Ala Gly Ile Leu Ala Arg Trp Gly Ser           
                60                  65                  70                

ttc aag aag aat gga gcg att aaa gtg tta cgg ggt ttc aag aga gaa        355
Phe Lys Lys Asn Gly Ala Ile Lys Val Leu Arg Gly Phe Lys Arg Glu           
            75                  80                  85                    

atc tca aac atg cta aac ata atg aac agg agg aaa aga tcc gtg acc        403
Ile Ser Asn Met Leu Asn Ile Met Asn Arg Arg Lys Arg Ser Val Thr           
        90                  95                  100                       

atg ctc ctt atg ctg ctg ccc aca gcc ctg gcg ttc cat ctg acg aca        451
Met Leu Leu Met Leu Leu Pro Thr Ala Leu Ala Phe His Leu Thr Thr           
    105                 110                 115                           

cga ggg gga gag ccg cat atg ata gtt agc aag cag gaa aga gga aag        499
Arg Gly Gly Glu Pro His Met Ile Val Ser Lys Gln Glu Arg Gly Lys           
120                 125                 130                 135           

tca ctt ttg ttc aag acc tct gca ggt gtc aac atg tgc acc ctc att        547
Ser Leu Leu Phe Lys Thr Ser Ala Gly Val Asn Met Cys Thr Leu Ile           
                140                 145                 150               

gcg atg gat ttg gga gag ttg tgt gag gac acg atg acc tac aaa tgc        595
Ala Met Asp Leu Gly Glu Leu Cys Glu Asp Thr Met Thr Tyr Lys Cys           
            155                 160                 165                   

ccc cgg atc act gag gcg gaa cca gat gac gtt gac tgt tgg tgc aat        643
Pro Arg Ile Thr Glu Ala Glu Pro Asp Asp Val Asp Cys Trp Cys Asn           
        170                 175                 180                       

gcc acg gac aca tgg gtg acc tat gga acg tgc tct caa act ggc gaa        691
Ala Thr Asp Thr Trp Val Thr Tyr Gly Thr Cys Ser Gln Thr Gly Glu           
    185                 190                 195                           

cac cga cga gac aaa cgt tcc gtc gca ttg gcc cca cac gtg ggg ctt        739
His Arg Arg Asp Lys Arg Ser Val Ala Leu Ala Pro His Val Gly Leu           
200                 205                 210                 215           

ggc cta gaa aca aga gcc gaa acg tgg atg tcc tct gaa ggt gct tgg        787
Gly Leu Glu Thr Arg Ala Glu Thr Trp Met Ser Ser Glu Gly Ala Trp           
                220                 225                 230               

aaa cag ata caa aaa gta gag act tgg gct ctg aga cat cca gga ttc        835
Lys Gln Ile Gln Lys Val Glu Thr Trp Ala Leu Arg His Pro Gly Phe           
            235                 240                 245                   

acg gtg ata gcc ctt ttt cta gca cat gcc ata gga aca tcc atc acc        883
Thr Val Ile Ala Leu Phe Leu Ala His Ala Ile Gly Thr Ser Ile Thr           
        250                 255                 260                       

cag aaa ggg atc att ttc att ttg ctg atg ctg gta aca cca tct atg        931
Gln Lys Gly Ile Ile Phe Ile Leu Leu Met Leu Val Thr Pro Ser Met           
    265                 270                 275                           

gcc atg cga tgc gtg gga ata ggc aac aga gac ttc gtg gaa gga ctg        979
Ala Met Arg Cys Val Gly Ile Gly Asn Arg Asp Phe Val Glu Gly Leu           
280                 285                 290                 295           

tca gga gca aca tgg gtg gat gtg gta ctg gag cat gga agt tgc gtc       1027
Ser Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Ser Cys Val           
                300                 305                 310               

acc acc atg gca aaa aac aaa cca aca ctg gac att gaa ctc ttg aag       1075
Thr Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Leu Lys           
            315                 320                 325                   

acg gag gtc aca aac cct gca gtt ctg cgt aaa ttg tgc att gaa gct       1123
Thr Glu Val Thr Asn Pro Ala Val Leu Arg Lys Leu Cys Ile Glu Ala           
        330                 335                 340                       

aaa ata tca aac acc acc acc gat tcg aga tgt cca aca caa gga gaa       1171
Lys Ile Ser Asn Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu           
    345                 350                 355                           

gcc aca ctg gtg gaa gaa caa gac gcg aac ttt gtg tgc cga cga acg       1219
Ala Thr Leu Val Glu Glu Gln Asp Ala Asn Phe Val Cys Arg Arg Thr           
360                 365                 370                 375           

ttc gtg gac aga ggc tgg ggc aat ggc tgt ggg cta ttc gga aaa ggt       1267
Phe Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly           
                380                 385                 390               

agt cta ata acg tgt gcc aag ttt aag tgt gtg aca aaa cta gaa gga       1315
Ser Leu Ile Thr Cys Ala Lys Phe Lys Cys Val Thr Lys Leu Glu Gly           
            395                 400                 405                   

aag ata gtt caa tat gaa aac cta aaa tat tca gtg ata gtc acc gtc       1363
Lys Ile Val Gln Tyr Glu Asn Leu Lys Tyr Ser Val Ile Val Thr Val           
        410                 415                 420                       

cac act gga gat cag cac cag gtg gga aat gag act aca gaa cat gga       1411
His Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Thr Glu His Gly           
    425                 430                 435                           

aca act gca acc ata aca cct caa gct cct acg tcg gaa ata cag ctg       1459
Thr Thr Ala Thr Ile Thr Pro Gln Ala Pro Thr Ser Glu Ile Gln Leu           
440                 445                 450                 455           

acc gac tac gga acc ctt aca tta gat tgt tca cct agg aca ggg cta       1507
Thr Asp Tyr Gly Thr Leu Thr Leu Asp Cys Ser Pro Arg Thr Gly Leu           
                460                 465                 470               

gat ttt aac gag atg gtg ttg ctg aca atg aaa gaa aga tca tgg ctt       1555
Asp Phe Asn Glu Met Val Leu Leu Thr Met Lys Glu Arg Ser Trp Leu           
            475                 480                 485                   

gtc cac aaa caa tgg ttt cta gac tta cca ctg cct tgg acc tct ggg       1603
Val His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ser Gly           
        490                 495                 500                       

gct tca aca tcc caa gag act tgg aac aga caa gat tta ctg gtc aca       1651
Ala Ser Thr Ser Gln Glu Thr Trp Asn Arg Gln Asp Leu Leu Val Thr           
    505                 510                 515                           

ttt aag aca gct cat gca aag aag cag gaa gta gtc gta cta gga tca       1699
Phe Lys Thr Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser           
520                 525                 530                 535           

caa gaa gga gca atg cac act gcg ctg act gga gcg aca gaa atc caa       1747
Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln           
                540                 545                 550               

acg tca gga acg aca aca att ttc gca gga cac cta aaa tgc aga cta       1795
Thr Ser Gly Thr Thr Thr Ile Phe Ala Gly His Leu Lys Cys Arg Leu           
            555                 560                 565                   

aaa atg gac aaa cta act tta aaa ggg atg tca tat gtg atg tgc aca       1843
Lys Met Asp Lys Leu Thr Leu Lys Gly Met Ser Tyr Val Met Cys Thr           
        570                 575                 580                       

ggc tca ttc aag tta gag aaa gaa gtg gct gag acc cag cat gga act       1891
Gly Ser Phe Lys Leu Glu Lys Glu Val Ala Glu Thr Gln His Gly Thr           
    585                 590                 595                           

gtt ctg gtg cag gtt aaa tat gaa gga aca gac gca cca tgc aag att       1939
Val Leu Val Gln Val Lys Tyr Glu Gly Thr Asp Ala Pro Cys Lys Ile           
600                 605                 610                 615           

ccc ttt tcg acc caa gat gag aaa gga gca acc cag aat ggg aga tta       1987
Pro Phe Ser Thr Gln Asp Glu Lys Gly Ala Thr Gln Asn Gly Arg Leu           
                620                 625                 630               

ata aca gcc aac ccc ata gtc act gac aaa gaa aaa cca gtc aat att       2035
Ile Thr Ala Asn Pro Ile Val Thr Asp Lys Glu Lys Pro Val Asn Ile           
            635                 640                 645                   

gag gca gaa cca ccc ttt ggt gag agc tac atc gtg gta gga gca ggt       2083
Glu Ala Glu Pro Pro Phe Gly Glu Ser Tyr Ile Val Val Gly Ala Gly           
        650                 655                 660                       

gaa aaa gct ttg aaa cta agc tgg ttc aag aaa gga agc agc ata ggg       2131
Glu Lys Ala Leu Lys Leu Ser Trp Phe Lys Lys Gly Ser Ser Ile Gly           
    665                 670                 675                           

aaa atg ttt gaa gca act gcc cga gga gca cga agg atg gcc att ctg       2179
Lys Met Phe Glu Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu           
680                 685                 690                 695           

gga gac acc gca tgg gac ttc ggt tct ata gga gga gtg ttc acg tct       2227
Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Thr Ser           
                700                 705                 710               

atg gga aaa ctg gta cac cag gtt ttt gga act gca tat gga gtt ttg       2275
Met Gly Lys Leu Val His Gln Val Phe Gly Thr Ala Tyr Gly Val Leu           
            715                 720                 725                   

ttt agc gga gtt tct tgg acc atg aaa ata gga ata ggg att ctg ctg       2323
Phe Ser Gly Val Ser Trp Thr Met Lys Ile Gly Ile Gly Ile Leu Leu           
        730                 735                 740                       

aca tgg cta gga tta aat tca agg aac acg tcc ctt tcg atg atg tgc       2371
Thr Trp Leu Gly Leu Asn Ser Arg Asn Thr Ser Leu Ser Met Met Cys           
    745                 750                 755                           

atc gca gtt ggc atg gtc aca ctg tac cta gga gtc atg gtt cag gca       2419
Ile Ala Val Gly Met Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala           
760                 765                 770                 775           

gat tcg gga tgt gta atc aac tgg aaa ggc aga gaa ctt aaa tgt gga       2467
Asp Ser Gly Cys Val Ile Asn Trp Lys Gly Arg Glu Leu Lys Cys Gly           
                780                 785                 790               

agc ggc att ttt gtc act aat gaa gtt cac act tgg aca gag caa tac       2515
Ser Gly Ile Phe Val Thr Asn Glu Val His Thr Trp Thr Glu Gln Tyr           
            795                 800                 805                   

aaa ttc cag gct gac tcc ccc aag aga cta tca gca gcc att ggg aag       2563
Lys Phe Gln Ala Asp Ser Pro Lys Arg Leu Ser Ala Ala Ile Gly Lys           
        810                 815                 820                       

gca tgg gag gag ggt gtg tgt gga atc cga tca gcc act cgt ctc gag       2611
Ala Trp Glu Glu Gly Val Cys Gly Ile Arg Ser Ala Thr Arg Leu Glu           
    825                 830                 835                           

aac atc atg tgg aaa caa ata tca aat gaa ttg aac cac atc cta ctt       2659
Asn Ile Met Trp Lys Gln Ile Ser Asn Glu Leu Asn His Ile Leu Leu           
840                 845                 850                 855           

gaa aat gac atg aaa ttt aca gtg gtc gtg gga gat gtt agt gga atc       2707
Glu Asn Asp Met Lys Phe Thr Val Val Val Gly Asp Val Ser Gly Ile           
                860                 865                 870               

ttg gcc caa ggg aaa aaa atg att agg cca caa ccc atg gaa cac aaa       2755
Leu Ala Gln Gly Lys Lys Met Ile Arg Pro Gln Pro Met Glu His Lys           
            875                 880                 885                   

tac tcg tgg aaa agc tgg gga aaa gcc aaa atc ata gga gcg gat gta       2803
Tyr Ser Trp Lys Ser Trp Gly Lys Ala Lys Ile Ile Gly Ala Asp Val           
        890                 895                 900                       

cag aac acc acc ttc atc atc gac ggc cca aac acc cca gaa tgc cct       2851
Gln Asn Thr Thr Phe Ile Ile Asp Gly Pro Asn Thr Pro Glu Cys Pro           
    905                 910                 915                           

gac aat caa aga gca tgg aat att tgg gaa gta gag gac tat gga ttt       2899
Asp Asn Gln Arg Ala Trp Asn Ile Trp Glu Val Glu Asp Tyr Gly Phe           
920                 925                 930                 935           

ggg att ttc acg aca aac ata tgg ttg aaa ttg cgt gac tcc tac acc       2947
Gly Ile Phe Thr Thr Asn Ile Trp Leu Lys Leu Arg Asp Ser Tyr Thr           
                940                 945                 950               

caa gta tgt gac cac cgg ctg atg tca gct gcc att aag gac agc aag       2995
Gln Val Cys Asp His Arg Leu Met Ser Ala Ala Ile Lys Asp Ser Lys           
            955                 960                 965                   

gca gtc cat gct gac atg ggg tac tgg ata gaa agt gaa aag aac gag       3043
Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu Ser Glu Lys Asn Glu           
        970                 975                 980                       

aca tgg aag ttg gcg aga gcc tcc ttt ata gaa gtt aag aca tgc atc       3091
Thr Trp Lys Leu Ala Arg Ala Ser Phe Ile Glu Val Lys Thr Cys Ile           
    985                 990                 995                           

tgg  cca aaa tcc cac act  cta tgg agc aat gga  gtt ctg gaa agt        3136
Trp  Pro Lys Ser His Thr  Leu Trp Ser Asn Gly  Val Leu Glu Ser            
1000                 1005                 1010                            

gaa  atg ata att cca aag  ata tat gga gga cca  ata tct cag cac        3181
Glu  Met Ile Ile Pro Lys  Ile Tyr Gly Gly Pro  Ile Ser Gln His            
1015                 1020                 1025                            

aac  tac aga cca gga tat  ttc aca caa aca gca  ggg ccg tgg cac        3226
Asn  Tyr Arg Pro Gly Tyr  Phe Thr Gln Thr Ala  Gly Pro Trp His            
1030                 1035                 1040                            

cta  ggc aag ttg gaa cta  gat ttc gat ttt tgt  gaa ggt acc aca        3271
Leu  Gly Lys Leu Glu Leu  Asp Phe Asp Phe Cys  Glu Gly Thr Thr            
1045                 1050                 1055                            

gtt  gtt gtg gat gaa cat  tgt gga aat cga gga  cca tct ctc aga        3316
Val  Val Val Asp Glu His  Cys Gly Asn Arg Gly  Pro Ser Leu Arg            
1060                 1065                 1070                            

acc  aca aca gtc aca gga  aag ata atc cat gaa  tgg tgc tgc aga        3361
Thr  Thr Thr Val Thr Gly  Lys Ile Ile His Glu  Trp Cys Cys Arg            
1075                 1080                 1085                            

tct  tgt acg cta ccc ccc  cta cgt ttc aaa ggg  gaa gac ggg tgt        3406
Ser  Cys Thr Leu Pro Pro  Leu Arg Phe Lys Gly  Glu Asp Gly Cys            
1090                 1095                 1100                            

tgg  tac ggc atg gaa atc  aga cca gtg aag gac  aag gaa gag aac        3451
Trp  Tyr Gly Met Glu Ile  Arg Pro Val Lys Asp  Lys Glu Glu Asn            
1105                 1110                 1115                            

ctg  gtc aag tca atg gtc  tct gca ggg tca gga  gaa gtg gac agc        3496
Leu  Val Lys Ser Met Val  Ser Ala Gly Ser Gly  Glu Val Asp Ser            
1120                 1125                 1130                            

ttt  tca cta gga ctg cta  tgc ata tca ata atg  att gaa gaa gtg        3541
Phe  Ser Leu Gly Leu Leu  Cys Ile Ser Ile Met  Ile Glu Glu Val            
1135                 1140                 1145                            

atg  aga tcc aga tgg agc  aaa aaa atg ctg atg  act gga aca ctg        3586
Met  Arg Ser Arg Trp Ser  Lys Lys Met Leu Met  Thr Gly Thr Leu            
1150                 1155                 1160                            

gct  gtg ttc ctc ctt ctt  ata atg gga caa ttg  aca tgg agt gat        3631
Ala  Val Phe Leu Leu Leu  Ile Met Gly Gln Leu  Thr Trp Ser Asp            
1165                 1170                 1175                            

ctg  atc agg tta tgt att  atg gtt gga gcc aac  gct tca gac aag        3676
Leu  Ile Arg Leu Cys Ile  Met Val Gly Ala Asn  Ala Ser Asp Lys            
1180                 1185                 1190                            

atg  ggg atg gga aca acg  tac cta gct tta atg  gcc act ttc aaa        3721
Met  Gly Met Gly Thr Thr  Tyr Leu Ala Leu Met  Ala Thr Phe Lys            
1195                 1200                 1205                            

atg  aga cca atg ttc gcc  gtc ggg cta tta ttt  cgc aga cta aca        3766
Met  Arg Pro Met Phe Ala  Val Gly Leu Leu Phe  Arg Arg Leu Thr            
1210                 1215                 1220                            

tct  aga gaa gtt ctt ctt  ctt aca att ggc ttg  agc ctg gtg gca        3811
Ser  Arg Glu Val Leu Leu  Leu Thr Ile Gly Leu  Ser Leu Val Ala            
1225                 1230                 1235                            

tcc  gtg gag cta cca agt  tcc cta gag gag ctg  ggg gat gga ctt        3856
Ser  Val Glu Leu Pro Ser  Ser Leu Glu Glu Leu  Gly Asp Gly Leu            
1240                 1245                 1250                            

gca  ata ggc atc atg atg  ttg aaa tta ttg act  gat ttt cag tca        3901
Ala  Ile Gly Ile Met Met  Leu Lys Leu Leu Thr  Asp Phe Gln Ser            
1255                 1260                 1265                            

cac  cag cta tgg gct act  ctg cta tcc ttg aca  ttt att aaa aca        3946
His  Gln Leu Trp Ala Thr  Leu Leu Ser Leu Thr  Phe Ile Lys Thr            
1270                 1275                 1280                            

act  ttt tca ttg cac tat  gca tgg aag aca atg  gct atg gta ctg        3991
Thr  Phe Ser Leu His Tyr  Ala Trp Lys Thr Met  Ala Met Val Leu            
1285                 1290                 1295                            

tca  att gta tct ctc ttc  cct tta tgc ctg tcc  acg acc tct caa        4036
Ser  Ile Val Ser Leu Phe  Pro Leu Cys Leu Ser  Thr Thr Ser Gln            
1300                 1305                 1310                            

aaa  aca aca tgg ctt ccg  gtg ctg ttg gga tct  ctt gga tgc aaa        4081
Lys  Thr Thr Trp Leu Pro  Val Leu Leu Gly Ser  Leu Gly Cys Lys            
1315                 1320                 1325                            

cca  cta ccc atg ttt ctt  ata aca gaa aac aaa  atc tgg gga agg        4126
Pro  Leu Pro Met Phe Leu  Ile Thr Glu Asn Lys  Ile Trp Gly Arg            
1330                 1335                 1340                            

aag  agt tgg ccc ctc aat  gaa gga att atg gct  gtt gga ata gtt        4171
Lys  Ser Trp Pro Leu Asn  Glu Gly Ile Met Ala  Val Gly Ile Val            
1345                 1350                 1355                            

agt  att cta cta agt tca  ctt tta aaa aat gat  gtg ccg cta gcc        4216
Ser  Ile Leu Leu Ser Ser  Leu Leu Lys Asn Asp  Val Pro Leu Ala            
1360                 1365                 1370                            

ggc  cca tta ata gct gga  ggc atg cta ata gca  tgt tat gtc ata        4261
Gly  Pro Leu Ile Ala Gly  Gly Met Leu Ile Ala  Cys Tyr Val Ile            
1375                 1380                 1385                            

tcc  gga agc tca gct gat  tta tca ctg gag aaa  gcg gct gag gtc        4306
Ser  Gly Ser Ser Ala Asp  Leu Ser Leu Glu Lys  Ala Ala Glu Val            
1390                 1395                 1400                            

tcc  tgg gag gaa gaa gca  gaa cac tca ggc gcc  tca cac aac ata        4351
Ser  Trp Glu Glu Glu Ala  Glu His Ser Gly Ala  Ser His Asn Ile            
1405                 1410                 1415                            

cta  gta gag gtt caa gat  gat gga acc atg aag  ata aaa gat gaa        4396
Leu  Val Glu Val Gln Asp  Asp Gly Thr Met Lys  Ile Lys Asp Glu            
1420                 1425                 1430                            

gag  aga gat gac acg ctc  acc att ctc ctt aaa  gca act ctg ctg        4441
Glu  Arg Asp Asp Thr Leu  Thr Ile Leu Leu Lys  Ala Thr Leu Leu            
1435                 1440                 1445                            

gca  gtc tca ggg gtg tac  cca atg tca ata cca  gcg acc ctt ttt        4486
Ala  Val Ser Gly Val Tyr  Pro Met Ser Ile Pro  Ala Thr Leu Phe            
1450                 1455                 1460                            

gtg  tgg tat ttt tgg cag  aaa aag aaa cag aga  tca gga gtg cta        4531
Val  Trp Tyr Phe Trp Gln  Lys Lys Lys Gln Arg  Ser Gly Val Leu            
1465                 1470                 1475                            

tgg  gac aca ccc agc ccc  cca gaa gtg gaa aga  gca gtt ctt gat        4576
Trp  Asp Thr Pro Ser Pro  Pro Glu Val Glu Arg  Ala Val Leu Asp            
1480                 1485                 1490                            

gat  ggc atc tat aga att  ttg caa aga gga ctg  ttg ggc agg tcc        4621
Asp  Gly Ile Tyr Arg Ile  Leu Gln Arg Gly Leu  Leu Gly Arg Ser            
1495                 1500                 1505                            

caa  gta gga gta gga gtt  ttc caa gaa ggc gtg  ttc cac aca atg        4666
Gln  Val Gly Val Gly Val  Phe Gln Glu Gly Val  Phe His Thr Met            
1510                 1515                 1520                            

tgg  cac gtc act agg gga  gct gtc ctc atg tat  caa gga aaa agg        4711
Trp  His Val Thr Arg Gly  Ala Val Leu Met Tyr  Gln Gly Lys Arg            
1525                 1530                 1535                            

ctg  gaa cca agc tgg gcc  agt gtc aaa aaa gac  ttg atc tca tat        4756
Leu  Glu Pro Ser Trp Ala  Ser Val Lys Lys Asp  Leu Ile Ser Tyr            
1540                 1545                 1550                            

gga  gga ggt tgg agg ttt  caa gga tcc tgg aac  acg gga gaa gaa        4801
Gly  Gly Gly Trp Arg Phe  Gln Gly Ser Trp Asn  Thr Gly Glu Glu            
1555                 1560                 1565                            

gta  cag gtg att gct gtt  gaa ccg gga aaa aac  ccc aaa aat gta        4846
Val  Gln Val Ile Ala Val  Glu Pro Gly Lys Asn  Pro Lys Asn Val            
1570                 1575                 1580                            

caa  aca acg ccg ggt acc  ttc aag acc cct gaa  ggc gaa gtt gga        4891
Gln  Thr Thr Pro Gly Thr  Phe Lys Thr Pro Glu  Gly Glu Val Gly            
1585                 1590                 1595                            

gcc  ata gcc tta gac ttt  aaa cct ggc aca tct  gga tct ccc atc        4936
Ala  Ile Ala Leu Asp Phe  Lys Pro Gly Thr Ser  Gly Ser Pro Ile            
1600                 1605                 1610                            

gta  aac aga gag gga aaa  ata gta ggt ctt tat  gga aat gga gtg        4981
Val  Asn Arg Glu Gly Lys  Ile Val Gly Leu Tyr  Gly Asn Gly Val            
1615                 1620                 1625                            

gtg  aca aca agc gga act  tac gtt agt gcc ata  gct caa gct aag        5026
Val  Thr Thr Ser Gly Thr  Tyr Val Ser Ala Ile  Ala Gln Ala Lys            
1630                 1635                 1640                            

gca  tca caa gaa ggg cct  cta cca gag att gag  gac gag gtg ttt        5071
Ala  Ser Gln Glu Gly Pro  Leu Pro Glu Ile Glu  Asp Glu Val Phe            
1645                 1650                 1655                            

agg  aaa aga aac tta aca  ata atg gac cta cat  cca gga tcg gga        5116
Arg  Lys Arg Asn Leu Thr  Ile Met Asp Leu His  Pro Gly Ser Gly            
1660                 1665                 1670                            

aaa  aca aga aga tac ctt  cca gcc ata gtc cgt  gag gcc ata aaa        5161
Lys  Thr Arg Arg Tyr Leu  Pro Ala Ile Val Arg  Glu Ala Ile Lys            
1675                 1680                 1685                            

agg  aag ctg cgc acg cta  atc cta gct ccc aca  aga gtt gtc gct        5206
Arg  Lys Leu Arg Thr Leu  Ile Leu Ala Pro Thr  Arg Val Val Ala            
1690                 1695                 1700                            

tct  gaa atg gca gag gca  ctc aag gga gtg cca  ata agg tat cag        5251
Ser  Glu Met Ala Glu Ala  Leu Lys Gly Val Pro  Ile Arg Tyr Gln            
1705                 1710                 1715                            

aca  aca gca gtg aag agt  gaa cac aca gga aag  gag ata gtt gac        5296
Thr  Thr Ala Val Lys Ser  Glu His Thr Gly Lys  Glu Ile Val Asp            
1720                 1725                 1730                            

ctt  atg tgc cac gcc act  ttc acc atg cgc ctc  ctg tct ccc gtg        5341
Leu  Met Cys His Ala Thr  Phe Thr Met Arg Leu  Leu Ser Pro Val            
1735                 1740                 1745                            

aga  gtt ccc aat tat aac  atg att atc atg gat  gaa gca cac ttc        5386
Arg  Val Pro Asn Tyr Asn  Met Ile Ile Met Asp  Glu Ala His Phe            
1750                 1755                 1760                            

acc  gat cca gcc agc ata  gca gcc aga ggg tac  atc tca acc cga        5431
Thr  Asp Pro Ala Ser Ile  Ala Ala Arg Gly Tyr  Ile Ser Thr Arg            
1765                 1770                 1775                            

gtg  ggt atg ggt gaa gca  gct gcg atc ttt atg  aca gcc act ccc        5476
Val  Gly Met Gly Glu Ala  Ala Ala Ile Phe Met  Thr Ala Thr Pro            
1780                 1785                 1790                            

cca  gga tcg gtg gag gcc  ttt cca cag agc aat  gca att atc caa        5521
Pro  Gly Ser Val Glu Ala  Phe Pro Gln Ser Asn  Ala Ile Ile Gln            
1795                 1800                 1805                            

gat  gag gaa aga gac att  cct gag aga tca tgg  aac tca ggc tat        5566
Asp  Glu Glu Arg Asp Ile  Pro Glu Arg Ser Trp  Asn Ser Gly Tyr            
1810                 1815                 1820                            

gac  tgg atc act gat ttt  cca ggt aaa aca gtc  tgg ttt gtt cca        5611
Asp  Trp Ile Thr Asp Phe  Pro Gly Lys Thr Val  Trp Phe Val Pro            
1825                 1830                 1835                            

agc  atc aaa tca gga aat  gac att gcc aac tgt  tta aga aaa aac        5656
Ser  Ile Lys Ser Gly Asn  Asp Ile Ala Asn Cys  Leu Arg Lys Asn            
1840                 1845                 1850                            

ggg  aaa cgg gtg atc caa  ttg agc aga aaa acc  ttt gac act gag        5701
Gly  Lys Arg Val Ile Gln  Leu Ser Arg Lys Thr  Phe Asp Thr Glu            
1855                 1860                 1865                            

tac  cag aaa aca aaa aac  aac gac tgg gac tat  gtc gtc aca aca        5746
Tyr  Gln Lys Thr Lys Asn  Asn Asp Trp Asp Tyr  Val Val Thr Thr            
1870                 1875                 1880                            

gac  att tcc gaa atg gga  gca aat ttc cgg gcc  gac agg gta ata        5791
Asp  Ile Ser Glu Met Gly  Ala Asn Phe Arg Ala  Asp Arg Val Ile            
1885                 1890                 1895                            

gac  cca agg cgg tgt ctg  aaa ccg gta ata cta  aaa gat ggt cca        5836
Asp  Pro Arg Arg Cys Leu  Lys Pro Val Ile Leu  Lys Asp Gly Pro            
1900                 1905                 1910                            

gag  cgc gtc att cta gcc  gga ccg atg cca gtg  act gtg gcc agt        5881
Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr Val Ala Ser            
1915                 1920                 1925                            

gcc  gcc cag agg aga gga  aga att gga agg aac  caa aac aag gaa        5926
Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Gln Asn Lys Glu            
1930                 1935                 1940                            

ggt  gat cag tat att tac  atg gga cag cct tta  aac aat gat gag        5971
Gly  Asp Gln Tyr Ile Tyr  Met Gly Gln Pro Leu  Asn Asn Asp Glu            
1945                 1950                 1955                            

gac  cac gct cat tgg aca  gaa gca aag atg ctc  ctt gac aat ata        6016
Asp  His Ala His Trp Thr  Glu Ala Lys Met Leu  Leu Asp Asn Ile            
1960                 1965                 1970                            

aac  aca cca gaa ggg att  atc cca gcc ctc tat  gag ccg gag aga        6061
Asn  Thr Pro Glu Gly Ile  Ile Pro Ala Leu Tyr  Glu Pro Glu Arg            
1975                 1980                 1985                            

gaa  aag agt gca gct ata  gac ggg gaa tac aga  ctg cgg ggt gaa        6106
Glu  Lys Ser Ala Ala Ile  Asp Gly Glu Tyr Arg  Leu Arg Gly Glu            
1990                 1995                 2000                            

gca  agg aaa acg ttc gtg  gag ctc atg aga aga  ggg gat cta cca        6151
Ala  Arg Lys Thr Phe Val  Glu Leu Met Arg Arg  Gly Asp Leu Pro            
2005                 2010                 2015                            

gtc  tgg cta tcc tac aaa  gtt gcc tca gaa ggc  ttc cag tac tcc        6196
Val  Trp Leu Ser Tyr Lys  Val Ala Ser Glu Gly  Phe Gln Tyr Ser            
2020                 2025                 2030                            

gac  aga agg tgg tgc ttc  gat ggg gaa agg aac  aac cag gtg ttg        6241
Asp  Arg Arg Trp Cys Phe  Asp Gly Glu Arg Asn  Asn Gln Val Leu            
2035                 2040                 2045                            

gag  gag aac atg gac gtg  gag atc tgg aca aaa  gaa gga gaa aga        6286
Glu  Glu Asn Met Asp Val  Glu Ile Trp Thr Lys  Glu Gly Glu Arg            
2050                 2055                 2060                            

aag  aaa cta cga cct cgc  tgg ttg gac gcc aga  aca tac tct gac        6331
Lys  Lys Leu Arg Pro Arg  Trp Leu Asp Ala Arg  Thr Tyr Ser Asp            
2065                 2070                 2075                            

cca  ctg gct ctg cgc gag  ttt aaa gag ttt gca  gca gga aga aga        6376
Pro  Leu Ala Leu Arg Glu  Phe Lys Glu Phe Ala  Ala Gly Arg Arg            
2080                 2085                 2090                            

agc  gtc tca ggt gac cta  ata tta gaa ata ggg  aaa ctt cca caa        6421
Ser  Val Ser Gly Asp Leu  Ile Leu Glu Ile Gly  Lys Leu Pro Gln            
2095                 2100                 2105                            

cat  ttg acg caa agg gcc  cag aat gct ttg gac  aac ttg gtc atg        6466
His  Leu Thr Gln Arg Ala  Gln Asn Ala Leu Asp  Asn Leu Val Met            
2110                 2115                 2120                            

ttg  cac aat tcc gaa caa  gga gga aaa gcc tat  aga cat gct atg        6511
Leu  His Asn Ser Glu Gln  Gly Gly Lys Ala Tyr  Arg His Ala Met            
2125                 2130                 2135                            

gaa  gaa ctg cca gac aca  ata gaa acg ttg atg  ctc cta gcc ttg        6556
Glu  Glu Leu Pro Asp Thr  Ile Glu Thr Leu Met  Leu Leu Ala Leu            
2140                 2145                 2150                            

ata  gct gtg ttg act ggt  gga gtg acg ctg ttc  ttc cta tca gga        6601
Ile  Ala Val Leu Thr Gly  Gly Val Thr Leu Phe  Phe Leu Ser Gly            
2155                 2160                 2165                            

aga  ggt cta gga aaa aca  tct atc ggc tta ctc  tgc gtg atg gcc        6646
Arg  Gly Leu Gly Lys Thr  Ser Ile Gly Leu Leu  Cys Val Met Ala            
2170                 2175                 2180                            

tca  agc gca ctg tta tgg  atg gcc agt gtg gag  ccc cat tgg ata        6691
Ser  Ser Ala Leu Leu Trp  Met Ala Ser Val Glu  Pro His Trp Ile            
2185                 2190                 2195                            

gcg  gcc tcc atc ata ctg  gag ttc ttt ctg atg  gta ctg ctt att        6736
Ala  Ala Ser Ile Ile Leu  Glu Phe Phe Leu Met  Val Leu Leu Ile            
2200                 2205                 2210                            

cca  gag cca gac aga cag  cgc act cca cag gac  aac cag cta gca        6781
Pro  Glu Pro Asp Arg Gln  Arg Thr Pro Gln Asp  Asn Gln Leu Ala            
2215                 2220                 2225                            

tat  gtg gtg ata ggt ctg  tta ttc atg ata ttg  aca gtg gca gcc        6826
Tyr  Val Val Ile Gly Leu  Leu Phe Met Ile Leu  Thr Val Ala Ala            
2230                 2235                 2240                            

aat  gag atg gga tta ttg  gaa acc aca aag aaa  gac ctg ggg att        6871
Asn  Glu Met Gly Leu Leu  Glu Thr Thr Lys Lys  Asp Leu Gly Ile            
2245                 2250                 2255                            

ggc  cat gta gct gct gaa  aac cac cac cat gct  aca atg ctg gac        6916
Gly  His Val Ala Ala Glu  Asn His His His Ala  Thr Met Leu Asp            
2260                 2265                 2270                            

gta  gac cta cat cca gct  tca gcc tgg acc ctc  tat gca gtg gcc        6961
Val  Asp Leu His Pro Ala  Ser Ala Trp Thr Leu  Tyr Ala Val Ala            
2275                 2280                 2285                            

aca  aca atc atc act cct  atg atg aga cac aca  att gaa aac aca        7006
Thr  Thr Ile Ile Thr Pro  Met Met Arg His Thr  Ile Glu Asn Thr            
2290                 2295                 2300                            

acg  gca aat att tcc ctg  aca gcc atc gca aac  caa gca gct ata        7051
Thr  Ala Asn Ile Ser Leu  Thr Ala Ile Ala Asn  Gln Ala Ala Ile            
2305                 2310                 2315                            

ttg  atg gga ctt gac aag  gga tgg cca ata tcg  aag atg gac ata        7096
Leu  Met Gly Leu Asp Lys  Gly Trp Pro Ile Ser  Lys Met Asp Ile            
2320                 2325                 2330                            

gga  gtt cca ctt ctc gcc  ttg ggg tgc tat tcc  caa gtg aat ccg        7141
Gly  Val Pro Leu Leu Ala  Leu Gly Cys Tyr Ser  Gln Val Asn Pro            
2335                 2340                 2345                            

ctg  aca ctg ata gcg gca  gta ttg atg cta gta  gct cat tac gcc        7186
Leu  Thr Leu Ile Ala Ala  Val Leu Met Leu Val  Ala His Tyr Ala            
2350                 2355                 2360                            

ata  att gga cct gga ctg  caa gca aaa gct act  aga gaa gct caa        7231
Ile  Ile Gly Pro Gly Leu  Gln Ala Lys Ala Thr  Arg Glu Ala Gln            
2365                 2370                 2375                            

aaa  aga aca gcg gct gga  ata atg aaa aat cca  act gtc gac ggg        7276
Lys  Arg Thr Ala Ala Gly  Ile Met Lys Asn Pro  Thr Val Asp Gly            
2380                 2385                 2390                            

att  gtt gca ata gac tta  gat ccc gtg gtt tac  gat gca aaa ttt        7321
Ile  Val Ala Ile Asp Leu  Asp Pro Val Val Tyr  Asp Ala Lys Phe            
2395                 2400                 2405                            

gaa  aaa caa cta ggc caa  ata atg ttg ttg ata  ctt tgc aca tca        7366
Glu  Lys Gln Leu Gly Gln  Ile Met Leu Leu Ile  Leu Cys Thr Ser            
2410                 2415                 2420                            

cag  att ctt ttg atg cgg  act aca tgg gcc ttg  tgt gaa tcc atc        7411
Gln  Ile Leu Leu Met Arg  Thr Thr Trp Ala Leu  Cys Glu Ser Ile            
2425                 2430                 2435                            

aca  ttg gct act gga cct  ctg acc act ctt tgg  gag gga tct cca        7456
Thr  Leu Ala Thr Gly Pro  Leu Thr Thr Leu Trp  Glu Gly Ser Pro            
2440                 2445                 2450                            

gga  aaa ttc tgg aac acc  aca ata gcg gta tcc  atg gca aac att        7501
Gly  Lys Phe Trp Asn Thr  Thr Ile Ala Val Ser  Met Ala Asn Ile            
2455                 2460                 2465                            

ttc  agg ggg agt tat cta  gca gga gca ggt ctg  gcc ttc tca tta        7546
Phe  Arg Gly Ser Tyr Leu  Ala Gly Ala Gly Leu  Ala Phe Ser Leu            
2470                 2475                 2480                            

atg  aaa tct cta gga gga  ggt agg aga ggc acg  gga gcc caa ggg        7591
Met  Lys Ser Leu Gly Gly  Gly Arg Arg Gly Thr  Gly Ala Gln Gly            
2485                 2490                 2495                            

gaa  aca ctg gga gaa aaa  tgg aaa aga caa cta  aac caa ctg agc        7636
Glu  Thr Leu Gly Glu Lys  Trp Lys Arg Gln Leu  Asn Gln Leu Ser            
2500                 2505                 2510                            

aag  tca gaa ttc aat act  tac aag agg agt ggg  att atg gag gtg        7681
Lys  Ser Glu Phe Asn Thr  Tyr Lys Arg Ser Gly  Ile Met Glu Val            
2515                 2520                 2525                            

gat  aga tcc gaa gcc aaa  gag gga ctg aaa aga  gga gaa aca acc        7726
Asp  Arg Ser Glu Ala Lys  Glu Gly Leu Lys Arg  Gly Glu Thr Thr            
2530                 2535                 2540                            

aaa  cac gca gta tcg aga  gga acg gcc aaa ctg  agg tgg ttc gtg        7771
Lys  His Ala Val Ser Arg  Gly Thr Ala Lys Leu  Arg Trp Phe Val            
2545                 2550                 2555                            

gag  agg aac ctt gtg aaa  cca gaa ggg aaa gtc  ata gac ctc ggt        7816
Glu  Arg Asn Leu Val Lys  Pro Glu Gly Lys Val  Ile Asp Leu Gly            
2560                 2565                 2570                            

tgt  gga aga ggt ggc tgg  tca tat tat tgc gct  ggg ctg aag aaa        7861
Cys  Gly Arg Gly Gly Trp  Ser Tyr Tyr Cys Ala  Gly Leu Lys Lys            
2575                 2580                 2585                            

gtc  aca gaa gtg aaa gga  tac aca aaa gga gga  cct gga cat gag        7906
Val  Thr Glu Val Lys Gly  Tyr Thr Lys Gly Gly  Pro Gly His Glu            
2590                 2595                 2600                            

gaa  cca atc cca atg gcg  acc tat gga tgg aac  cta gta aag ctg        7951
Glu  Pro Ile Pro Met Ala  Thr Tyr Gly Trp Asn  Leu Val Lys Leu            
2605                 2610                 2615                            

cac  tcc gga aaa gat gta  ttt ttt ata cca cct  gag aaa tgt gac        7996
His  Ser Gly Lys Asp Val  Phe Phe Ile Pro Pro  Glu Lys Cys Asp            
2620                 2625                 2630                            

acc  ctt ttg tgt gat att  ggt gag tcc tct ccg  aac cca act ata        8041
Thr  Leu Leu Cys Asp Ile  Gly Glu Ser Ser Pro  Asn Pro Thr Ile            
2635                 2640                 2645                            

gag  gaa gga aga acg tta  cgt gtt ctg aaa atg  gtg gaa cca tgg        8086
Glu  Glu Gly Arg Thr Leu  Arg Val Leu Lys Met  Val Glu Pro Trp            
2650                 2655                 2660                            

ctc  aga gga aac caa ttt  tgc ata aaa att cta  aat ccc tat atg        8131
Leu  Arg Gly Asn Gln Phe  Cys Ile Lys Ile Leu  Asn Pro Tyr Met            
2665                 2670                 2675                            

ccg  agc gtg gta gaa act  ctg gaa caa atg caa  aga aaa cat gga        8176
Pro  Ser Val Val Glu Thr  Leu Glu Gln Met Gln  Arg Lys His Gly            
2680                 2685                 2690                            

gga  atg cta gtg cga aac  cca ctc tca aga aat  tcc acc cat gaa        8221
Gly  Met Leu Val Arg Asn  Pro Leu Ser Arg Asn  Ser Thr His Glu            
2695                 2700                 2705                            

atg  tac tgg gtt tca tgt  gga aca gga aac att  gtg tca gca gta        8266
Met  Tyr Trp Val Ser Cys  Gly Thr Gly Asn Ile  Val Ser Ala Val            
2710                 2715                 2720                            

aac  atg aca tct aga atg  ttg cta aat cgg ttc  aca atg gct cac        8311
Asn  Met Thr Ser Arg Met  Leu Leu Asn Arg Phe  Thr Met Ala His            
2725                 2730                 2735                            

agg  aag cca aca tat gaa  aga gac gtg gac tta  ggc gct gga aca        8356
Arg  Lys Pro Thr Tyr Glu  Arg Asp Val Asp Leu  Gly Ala Gly Thr            
2740                 2745                 2750                            

aga  cat gtg gca gta gaa  cca gag gta gcc aac  cta gat atc att        8401
Arg  His Val Ala Val Glu  Pro Glu Val Ala Asn  Leu Asp Ile Ile            
2755                 2760                 2765                            

ggc  cag agg ata gag aat  ata aaa aat gaa cat  aag tca aca tgg        8446
Gly  Gln Arg Ile Glu Asn  Ile Lys Asn Glu His  Lys Ser Thr Trp            
2770                 2775                 2780                            

cat  tat gat gag gac aat  cca tac aaa aca tgg  gcc tat cat gga        8491
His  Tyr Asp Glu Asp Asn  Pro Tyr Lys Thr Trp  Ala Tyr His Gly            
2785                 2790                 2795                            

tca  tat gag gtt aag cca  tca gga tcg gcc tca  tcc atg gtc aat        8536
Ser  Tyr Glu Val Lys Pro  Ser Gly Ser Ala Ser  Ser Met Val Asn            
2800                 2805                 2810                            

ggc  gtg gtg aga ttg ctc  acc aaa cca tgg gat  gtt atc ccc atg        8581
Gly  Val Val Arg Leu Leu  Thr Lys Pro Trp Asp  Val Ile Pro Met            
2815                 2820                 2825                            

gtc  aca caa ata gcc atg  act gat acc aca ccc  ttt gga caa cag        8626
Val  Thr Gln Ile Ala Met  Thr Asp Thr Thr Pro  Phe Gly Gln Gln            
2830                 2835                 2840                            

agg  gtg ttt aaa gag aaa  gtt gac acg cgc aca  cca aaa gca aaa        8671
Arg  Val Phe Lys Glu Lys  Val Asp Thr Arg Thr  Pro Lys Ala Lys            
2845                 2850                 2855                            

cgt  ggc aca gca caa att  atg gaa gtg aca gcc  agg tgg tta tgg        8716
Arg  Gly Thr Ala Gln Ile  Met Glu Val Thr Ala  Arg Trp Leu Trp            
2860                 2865                 2870                            

ggt  ttc ctt tct aga aac  aaa aaa ccc aga att  tgc aca aga gag        8761
Gly  Phe Leu Ser Arg Asn  Lys Lys Pro Arg Ile  Cys Thr Arg Glu            
2875                 2880                 2885                            

gag  ttt aca aga aaa gtt  agg tca aac gca gct  att gga gca gtg        8806
Glu  Phe Thr Arg Lys Val  Arg Ser Asn Ala Ala  Ile Gly Ala Val            
2890                 2895                 2900                            

ttc  gtt gat gaa aat caa  tgg aac tcg gca aaa  gaa gca gtg gaa        8851
Phe  Val Asp Glu Asn Gln  Trp Asn Ser Ala Lys  Glu Ala Val Glu            
2905                 2910                 2915                            

gac  gaa cgg ttc tgg gaa  ctt gtc cac aga gag  agg gag ctt cat        8896
Asp  Glu Arg Phe Trp Glu  Leu Val His Arg Glu  Arg Glu Leu His            
2920                 2925                 2930                            

aaa  cag ggg aaa tgt gcc  acg tgt gtc tac aat  atg atg ggg aag        8941
Lys  Gln Gly Lys Cys Ala  Thr Cys Val Tyr Asn  Met Met Gly Lys            
2935                 2940                 2945                            

aga  gag aaa aaa tta gga  gag ttc gga aag gca  aaa gga agt cgt        8986
Arg  Glu Lys Lys Leu Gly  Glu Phe Gly Lys Ala  Lys Gly Ser Arg            
2950                 2955                 2960                            

gca  ata tgg tac atg tgg  ttg gga gca cgc ttc  cta gag ttt gaa        9031
Ala  Ile Trp Tyr Met Trp  Leu Gly Ala Arg Phe  Leu Glu Phe Glu            
2965                 2970                 2975                            

gcc  ctt ggt ttc atg aat  gaa gat cac tgg ttc  agt aga gag aat        9076
Ala  Leu Gly Phe Met Asn  Glu Asp His Trp Phe  Ser Arg Glu Asn            
2980                 2985                 2990                            

tca  ctc agt gga gtg gaa  gga gaa gga ctc cac  aaa ctt gga tac        9121
Ser  Leu Ser Gly Val Glu  Gly Glu Gly Leu His  Lys Leu Gly Tyr            
2995                 3000                 3005                            

ata  ctc aga gac ata tca  agg att cca ggg ggg  aac atg tat gca        9166
Ile  Leu Arg Asp Ile Ser  Arg Ile Pro Gly Gly  Asn Met Tyr Ala            
3010                 3015                 3020                            

gat  gac aca gcc gga tgg  gac aca aga ata aca  gag gat gat ctc        9211
Asp  Asp Thr Ala Gly Trp  Asp Thr Arg Ile Thr  Glu Asp Asp Leu            
3025                 3030                 3035                            

cag  aat gag gct aaa atc  act gac atc atg gag  ccc gaa cat gcc        9256
Gln  Asn Glu Ala Lys Ile  Thr Asp Ile Met Glu  Pro Glu His Ala            
3040                 3045                 3050                            

ctg  ctg gct acg tca atc  ttt aag ctg acc tac  caa aat aag gtg        9301
Leu  Leu Ala Thr Ser Ile  Phe Lys Leu Thr Tyr  Gln Asn Lys Val            
3055                 3060                 3065                            

gta  agg gtg cag aga cca  gca aaa aat gga acc  gtg atg gat gtt        9346
Val  Arg Val Gln Arg Pro  Ala Lys Asn Gly Thr  Val Met Asp Val            
3070                 3075                 3080                            

ata  tcc aga cgt gac cag  aga ggc agt gga cag  gtt gga act tat        9391
Ile  Ser Arg Arg Asp Gln  Arg Gly Ser Gly Gln  Val Gly Thr Tyr            
3085                 3090                 3095                            

ggc  tta aac act ttc acc  aac atg gag gcc caa  ctg ata aga caa        9436
Gly  Leu Asn Thr Phe Thr  Asn Met Glu Ala Gln  Leu Ile Arg Gln            
3100                 3105                 3110                            

atg  gag tcc gag gga atc  ttt tta ccc agc gaa  ttg gaa acc cca        9481
Met  Glu Ser Glu Gly Ile  Phe Leu Pro Ser Glu  Leu Glu Thr Pro            
3115                 3120                 3125                            

aat  cta gcc gga aga gtt  ctc gac tgg ttg gaa  aaa tat ggt gtc        9526
Asn  Leu Ala Gly Arg Val  Leu Asp Trp Leu Glu  Lys Tyr Gly Val            
3130                 3135                 3140                            

gaa  agg ctg aaa aga atg  gca atc agc gga gat  gac tgt gtg gtg        9571
Glu  Arg Leu Lys Arg Met  Ala Ile Ser Gly Asp  Asp Cys Val Val            
3145                 3150                 3155                            

aaa  cca att gat gac agg  ttc gca aca gcc tta  aca gct ttg aat        9616
Lys  Pro Ile Asp Asp Arg  Phe Ala Thr Ala Leu  Thr Ala Leu Asn            
3160                 3165                 3170                            

gac  atg gga aaa gta aga  aaa gac ata cca caa  tgg gaa cct tca        9661
Asp  Met Gly Lys Val Arg  Lys Asp Ile Pro Gln  Trp Glu Pro Ser            
3175                 3180                 3185                            

aaa  gga tgg aat gat tgg  caa caa gtg cct ttc  tgt tca cac cac        9706
Lys  Gly Trp Asn Asp Trp  Gln Gln Val Pro Phe  Cys Ser His His            
3190                 3195                 3200                            

ttc  cac cag cta att atg  aag gat ggg agg gag  ata gtg gtg cca        9751
Phe  His Gln Leu Ile Met  Lys Asp Gly Arg Glu  Ile Val Val Pro            
3205                 3210                 3215                            

tgc  cgc aac caa gat gaa  ctt gtg ggg agg gcc  aga gta tca caa        9796
Cys  Arg Asn Gln Asp Glu  Leu Val Gly Arg Ala  Arg Val Ser Gln            
3220                 3225                 3230                            

ggc  gcc gga tgg agc ctg  aga gaa acc gca tgc  cta ggc aag tca        9841
Gly  Ala Gly Trp Ser Leu  Arg Glu Thr Ala Cys  Leu Gly Lys Ser            
3235                 3240                 3245                            

tat  gca caa atg tgg cag  ctg atg tat ttc cac  agg aga gac ctg        9886
Tyr  Ala Gln Met Trp Gln  Leu Met Tyr Phe His  Arg Arg Asp Leu            
3250                 3255                 3260                            

aga  ctg gcg gct aac gct  att tgt tca gcc gtt  cca gtt gat tgg        9931
Arg  Leu Ala Ala Asn Ala  Ile Cys Ser Ala Val  Pro Val Asp Trp            
3265                 3270                 3275                            

gtc  cca acc agc cgc acc  acc tgg tcg atc cat  gcc cat cac caa        9976
Val  Pro Thr Ser Arg Thr  Thr Trp Ser Ile His  Ala His His Gln            
3280                 3285                 3290                            

tgg  atg aca aca gaa gac  atg tta tca gta tgg  aat agg gtc tgg       10021
Trp  Met Thr Thr Glu Asp  Met Leu Ser Val Trp  Asn Arg Val Trp            
3295                 3300                 3305                            

ata  gag gaa aac cca tgg  atg gag gat aag act  cat gtg tcc agt       10066
Ile  Glu Glu Asn Pro Trp  Met Glu Asp Lys Thr  His Val Ser Ser            
3310                 3315                 3320                            

tgg  gaa gaa gtt cca tac  cta gga aag agg gaa  gat cag tgg tgt       10111
Trp  Glu Glu Val Pro Tyr  Leu Gly Lys Arg Glu  Asp Gln Trp Cys            
3325                 3330                 3335                            

gga  tcc ctg ata ggc tta  aca gca agg gcc acc  tgg gcc act aat       10156
Gly  Ser Leu Ile Gly Leu  Thr Ala Arg Ala Thr  Trp Ala Thr Asn            
3340                 3345                 3350                            

ata  caa gtg gcc ata aac  caa gtg aga agg ctc  att ggg aat gag       10201
Ile  Gln Val Ala Ile Asn  Gln Val Arg Arg Leu  Ile Gly Asn Glu            
3355                 3360                 3365                            

aat  tat cta gat tac atg  aca tca atg aag aga  ttc aag aat gag       10246
Asn  Tyr Leu Asp Tyr Met  Thr Ser Met Lys Arg  Phe Lys Asn Glu            
3370                 3375                 3380                            

agt  gat ccc gaa ggg gca  ctc tgg taa gtcaacacat tcacaaaata          10293
Ser  Asp Pro Glu Gly Ala  Leu Trp                                         
3385                 3390                                                 

aaggaaaata aaaaatcaaa tgaggcaaga agtcaggcca gattaagcca tagtacggta    10353

agagctatgc tgcctgtgag ccccgtccaa ggacgtaaaa tgaagtcagg ccgaaagcca    10413

cggtttgagc aagccgtgct gcctgtggct ccatcgtggg gatgtaaaaa cccgggaggc    10473

tgcaacccat ggaagctgta cgcatggggt agcagactag tggttagagg agacccctcc    10533

caagacacaa cgcagcagcg gggcccaaca ccaggggaag ctgtaccctg gtggtaagga    10593

ctagaggtta gaggagaccc cccgcgtaac aataaacagc atattgacgc tgggagagac    10653

cagagatcct gctgtctcta cagcatcatt ccaggcacag aacgccagaa aatggaatgg    10713

tgctgttgaa tcaacaggtt ct                                             10735


<210>  4
<211>  3392
<212>  PRT
<213>  Dengue virus type 1

<400>  4

Met Ile Asn Gln Arg Lys Lys Thr Gly Arg Pro Ser Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Ala Arg Asn Arg Val Ser Thr Val Ser Gln Leu Ala Lys Arg 
            20                  25                  30          


Phe Ser Lys Gly Leu Leu Ser Gly Gln Gly Pro Met Lys Leu Val Met 
        35                  40                  45              


Ala Phe Ile Ala Phe Leu Arg Phe Leu Ala Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Ala Arg Trp Gly Ser Phe Lys Lys Asn Gly Ala Ile Lys Val 
65                  70                  75                  80  


Leu Arg Gly Phe Lys Arg Glu Ile Ser Asn Met Leu Asn Ile Met Asn 
                85                  90                  95      


Arg Arg Lys Arg Ser Val Thr Met Leu Leu Met Leu Leu Pro Thr Ala 
            100                 105                 110         


Leu Ala Phe His Leu Thr Thr Arg Gly Gly Glu Pro His Met Ile Val 
        115                 120                 125             


Ser Lys Gln Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ser Ala Gly 
    130                 135                 140                 


Val Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Leu Cys Glu 
145                 150                 155                 160 


Asp Thr Met Thr Tyr Lys Cys Pro Arg Ile Thr Glu Ala Glu Pro Asp 
                165                 170                 175     


Asp Val Asp Cys Trp Cys Asn Ala Thr Asp Thr Trp Val Thr Tyr Gly 
            180                 185                 190         


Thr Cys Ser Gln Thr Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Ala Pro His Val Gly Leu Gly Leu Glu Thr Arg Ala Glu Thr Trp 
    210                 215                 220                 


Met Ser Ser Glu Gly Ala Trp Lys Gln Ile Gln Lys Val Glu Thr Trp 
225                 230                 235                 240 


Ala Leu Arg His Pro Gly Phe Thr Val Ile Ala Leu Phe Leu Ala His 
                245                 250                 255     


Ala Ile Gly Thr Ser Ile Thr Gln Lys Gly Ile Ile Phe Ile Leu Leu 
            260                 265                 270         


Met Leu Val Thr Pro Ser Met Ala Met Arg Cys Val Gly Ile Gly Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val 
    290                 295                 300                 


Leu Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Ile Glu Leu Leu Lys Thr Glu Val Thr Asn Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Ala 
        355                 360                 365             


Asn Phe Val Cys Arg Arg Thr Phe Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys 
385                 390                 395                 400 


Cys Val Thr Lys Leu Glu Gly Lys Ile Val Gln Tyr Glu Asn Leu Lys 
                405                 410                 415     


Tyr Ser Val Ile Val Thr Val His Thr Gly Asp Gln His Gln Val Gly 
            420                 425                 430         


Asn Glu Thr Thr Glu His Gly Thr Thr Ala Thr Ile Thr Pro Gln Ala 
        435                 440                 445             


Pro Thr Ser Glu Ile Gln Leu Thr Asp Tyr Gly Thr Leu Thr Leu Asp 
    450                 455                 460                 


Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Thr 
465                 470                 475                 480 


Met Lys Glu Arg Ser Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu 
                485                 490                 495     


Pro Leu Pro Trp Thr Ser Gly Ala Ser Thr Ser Gln Glu Thr Trp Asn 
            500                 505                 510         


Arg Gln Asp Leu Leu Val Thr Phe Lys Thr Ala His Ala Lys Lys Gln 
        515                 520                 525             


Glu Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu 
    530                 535                 540                 


Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly Thr Thr Thr Ile Phe Ala 
545                 550                 555                 560 


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Thr Leu Lys Gly 
                565                 570                 575     


Met Ser Tyr Val Met Cys Thr Gly Ser Phe Lys Leu Glu Lys Glu Val 
            580                 585                 590         


Ala Glu Thr Gln His Gly Thr Val Leu Val Gln Val Lys Tyr Glu Gly 
        595                 600                 605             


Thr Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Gln Asp Glu Lys Gly 
    610                 615                 620                 


Ala Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn Pro Ile Val Thr Asp 
625                 630                 635                 640 


Lys Glu Lys Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser 
                645                 650                 655     


Tyr Ile Val Val Gly Ala Gly Glu Lys Ala Leu Lys Leu Ser Trp Phe 
            660                 665                 670         


Lys Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly 
        675                 680                 685             


Ala Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser 
    690                 695                 700                 


Ile Gly Gly Val Phe Thr Ser Met Gly Lys Leu Val His Gln Val Phe 
705                 710                 715                 720 


Gly Thr Ala Tyr Gly Val Leu Phe Ser Gly Val Ser Trp Thr Met Lys 
                725                 730                 735     


Ile Gly Ile Gly Ile Leu Leu Thr Trp Leu Gly Leu Asn Ser Arg Asn 
            740                 745                 750         


Thr Ser Leu Ser Met Met Cys Ile Ala Val Gly Met Val Thr Leu Tyr 
        755                 760                 765             


Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val Ile Asn Trp Lys 
    770                 775                 780                 


Gly Arg Glu Leu Lys Cys Gly Ser Gly Ile Phe Val Thr Asn Glu Val 
785                 790                 795                 800 


His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Ala Asp Ser Pro Lys Arg 
                805                 810                 815     


Leu Ser Ala Ala Ile Gly Lys Ala Trp Glu Glu Gly Val Cys Gly Ile 
            820                 825                 830         


Arg Ser Ala Thr Arg Leu Glu Asn Ile Met Trp Lys Gln Ile Ser Asn 
        835                 840                 845             


Glu Leu Asn His Ile Leu Leu Glu Asn Asp Met Lys Phe Thr Val Val 
    850                 855                 860                 


Val Gly Asp Val Ser Gly Ile Leu Ala Gln Gly Lys Lys Met Ile Arg 
865                 870                 875                 880 


Pro Gln Pro Met Glu His Lys Tyr Ser Trp Lys Ser Trp Gly Lys Ala 
                885                 890                 895     


Lys Ile Ile Gly Ala Asp Val Gln Asn Thr Thr Phe Ile Ile Asp Gly 
            900                 905                 910         


Pro Asn Thr Pro Glu Cys Pro Asp Asn Gln Arg Ala Trp Asn Ile Trp 
        915                 920                 925             


Glu Val Glu Asp Tyr Gly Phe Gly Ile Phe Thr Thr Asn Ile Trp Leu 
    930                 935                 940                 


Lys Leu Arg Asp Ser Tyr Thr Gln Val Cys Asp His Arg Leu Met Ser 
945                 950                 955                 960 


Ala Ala Ile Lys Asp Ser Lys Ala Val His Ala Asp Met Gly Tyr Trp 
                965                 970                 975     


Ile Glu Ser Glu Lys Asn Glu Thr Trp Lys Leu Ala Arg Ala Ser Phe 
            980                 985                 990         


Ile Glu Val Lys Thr Cys Ile Trp  Pro Lys Ser His Thr  Leu Trp Ser 
        995                 1000                 1005             


Asn Gly  Val Leu Glu Ser Glu  Met Ile Ile Pro Lys  Ile Tyr Gly 
    1010                 1015                 1020             


Gly Pro  Ile Ser Gln His Asn  Tyr Arg Pro Gly Tyr  Phe Thr Gln 
    1025                 1030                 1035             


Thr Ala  Gly Pro Trp His Leu  Gly Lys Leu Glu Leu  Asp Phe Asp 
    1040                 1045                 1050             


Phe Cys  Glu Gly Thr Thr Val  Val Val Asp Glu His  Cys Gly Asn 
    1055                 1060                 1065             


Arg Gly  Pro Ser Leu Arg Thr  Thr Thr Val Thr Gly  Lys Ile Ile 
    1070                 1075                 1080             


His Glu  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Phe 
    1085                 1090                 1095             


Lys Gly  Glu Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Val 
    1100                 1105                 1110             


Lys Asp  Lys Glu Glu Asn Leu  Val Lys Ser Met Val  Ser Ala Gly 
    1115                 1120                 1125             


Ser Gly  Glu Val Asp Ser Phe  Ser Leu Gly Leu Leu  Cys Ile Ser 
    1130                 1135                 1140             


Ile Met  Ile Glu Glu Val Met  Arg Ser Arg Trp Ser  Lys Lys Met 
    1145                 1150                 1155             


Leu Met  Thr Gly Thr Leu Ala  Val Phe Leu Leu Leu  Ile Met Gly 
    1160                 1165                 1170             


Gln Leu  Thr Trp Ser Asp Leu  Ile Arg Leu Cys Ile  Met Val Gly 
    1175                 1180                 1185             


Ala Asn  Ala Ser Asp Lys Met  Gly Met Gly Thr Thr  Tyr Leu Ala 
    1190                 1195                 1200             


Leu Met  Ala Thr Phe Lys Met  Arg Pro Met Phe Ala  Val Gly Leu 
    1205                 1210                 1215             


Leu Phe  Arg Arg Leu Thr Ser  Arg Glu Val Leu Leu  Leu Thr Ile 
    1220                 1225                 1230             


Gly Leu  Ser Leu Val Ala Ser  Val Glu Leu Pro Ser  Ser Leu Glu 
    1235                 1240                 1245             


Glu Leu  Gly Asp Gly Leu Ala  Ile Gly Ile Met Met  Leu Lys Leu 
    1250                 1255                 1260             


Leu Thr  Asp Phe Gln Ser His  Gln Leu Trp Ala Thr  Leu Leu Ser 
    1265                 1270                 1275             


Leu Thr  Phe Ile Lys Thr Thr  Phe Ser Leu His Tyr  Ala Trp Lys 
    1280                 1285                 1290             


Thr Met  Ala Met Val Leu Ser  Ile Val Ser Leu Phe  Pro Leu Cys 
    1295                 1300                 1305             


Leu Ser  Thr Thr Ser Gln Lys  Thr Thr Trp Leu Pro  Val Leu Leu 
    1310                 1315                 1320             


Gly Ser  Leu Gly Cys Lys Pro  Leu Pro Met Phe Leu  Ile Thr Glu 
    1325                 1330                 1335             


Asn Lys  Ile Trp Gly Arg Lys  Ser Trp Pro Leu Asn  Glu Gly Ile 
    1340                 1345                 1350             


Met Ala  Val Gly Ile Val Ser  Ile Leu Leu Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Asn Asp  Val Pro Leu Ala Gly  Pro Leu Ile Ala Gly  Gly Met Leu 
    1370                 1375                 1380             


Ile Ala  Cys Tyr Val Ile Ser  Gly Ser Ser Ala Asp  Leu Ser Leu 
    1385                 1390                 1395             


Glu Lys  Ala Ala Glu Val Ser  Trp Glu Glu Glu Ala  Glu His Ser 
    1400                 1405                 1410             


Gly Ala  Ser His Asn Ile Leu  Val Glu Val Gln Asp  Asp Gly Thr 
    1415                 1420                 1425             


Met Lys  Ile Lys Asp Glu Glu  Arg Asp Asp Thr Leu  Thr Ile Leu 
    1430                 1435                 1440             


Leu Lys  Ala Thr Leu Leu Ala  Val Ser Gly Val Tyr  Pro Met Ser 
    1445                 1450                 1455             


Ile Pro  Ala Thr Leu Phe Val  Trp Tyr Phe Trp Gln  Lys Lys Lys 
    1460                 1465                 1470             


Gln Arg  Ser Gly Val Leu Trp  Asp Thr Pro Ser Pro  Pro Glu Val 
    1475                 1480                 1485             


Glu Arg  Ala Val Leu Asp Asp  Gly Ile Tyr Arg Ile  Leu Gln Arg 
    1490                 1495                 1500             


Gly Leu  Leu Gly Arg Ser Gln  Val Gly Val Gly Val  Phe Gln Glu 
    1505                 1510                 1515             


Gly Val  Phe His Thr Met Trp  His Val Thr Arg Gly  Ala Val Leu 
    1520                 1525                 1530             


Met Tyr  Gln Gly Lys Arg Leu  Glu Pro Ser Trp Ala  Ser Val Lys 
    1535                 1540                 1545             


Lys Asp  Leu Ile Ser Tyr Gly  Gly Gly Trp Arg Phe  Gln Gly Ser 
    1550                 1555                 1560             


Trp Asn  Thr Gly Glu Glu Val  Gln Val Ile Ala Val  Glu Pro Gly 
    1565                 1570                 1575             


Lys Asn  Pro Lys Asn Val Gln  Thr Thr Pro Gly Thr  Phe Lys Thr 
    1580                 1585                 1590             


Pro Glu  Gly Glu Val Gly Ala  Ile Ala Leu Asp Phe  Lys Pro Gly 
    1595                 1600                 1605             


Thr Ser  Gly Ser Pro Ile Val  Asn Arg Glu Gly Lys  Ile Val Gly 
    1610                 1615                 1620             


Leu Tyr  Gly Asn Gly Val Val  Thr Thr Ser Gly Thr  Tyr Val Ser 
    1625                 1630                 1635             


Ala Ile  Ala Gln Ala Lys Ala  Ser Gln Glu Gly Pro  Leu Pro Glu 
    1640                 1645                 1650             


Ile Glu  Asp Glu Val Phe Arg  Lys Arg Asn Leu Thr  Ile Met Asp 
    1655                 1660                 1665             


Leu His  Pro Gly Ser Gly Lys  Thr Arg Arg Tyr Leu  Pro Ala Ile 
    1670                 1675                 1680             


Val Arg  Glu Ala Ile Lys Arg  Lys Leu Arg Thr Leu  Ile Leu Ala 
    1685                 1690                 1695             


Pro Thr  Arg Val Val Ala Ser  Glu Met Ala Glu Ala  Leu Lys Gly 
    1700                 1705                 1710             


Val Pro  Ile Arg Tyr Gln Thr  Thr Ala Val Lys Ser  Glu His Thr 
    1715                 1720                 1725             


Gly Lys  Glu Ile Val Asp Leu  Met Cys His Ala Thr  Phe Thr Met 
    1730                 1735                 1740             


Arg Leu  Leu Ser Pro Val Arg  Val Pro Asn Tyr Asn  Met Ile Ile 
    1745                 1750                 1755             


Met Asp  Glu Ala His Phe Thr  Asp Pro Ala Ser Ile  Ala Ala Arg 
    1760                 1765                 1770             


Gly Tyr  Ile Ser Thr Arg Val  Gly Met Gly Glu Ala  Ala Ala Ile 
    1775                 1780                 1785             


Phe Met  Thr Ala Thr Pro Pro  Gly Ser Val Glu Ala  Phe Pro Gln 
    1790                 1795                 1800             


Ser Asn  Ala Ile Ile Gln Asp  Glu Glu Arg Asp Ile  Pro Glu Arg 
    1805                 1810                 1815             


Ser Trp  Asn Ser Gly Tyr Asp  Trp Ile Thr Asp Phe  Pro Gly Lys 
    1820                 1825                 1830             


Thr Val  Trp Phe Val Pro Ser  Ile Lys Ser Gly Asn  Asp Ile Ala 
    1835                 1840                 1845             


Asn Cys  Leu Arg Lys Asn Gly  Lys Arg Val Ile Gln  Leu Ser Arg 
    1850                 1855                 1860             


Lys Thr  Phe Asp Thr Glu Tyr  Gln Lys Thr Lys Asn  Asn Asp Trp 
    1865                 1870                 1875             


Asp Tyr  Val Val Thr Thr Asp  Ile Ser Glu Met Gly  Ala Asn Phe 
    1880                 1885                 1890             


Arg Ala  Asp Arg Val Ile Asp  Pro Arg Arg Cys Leu  Lys Pro Val 
    1895                 1900                 1905             


Ile Leu  Lys Asp Gly Pro Glu  Arg Val Ile Leu Ala  Gly Pro Met 
    1910                 1915                 1920             


Pro Val  Thr Val Ala Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly 
    1925                 1930                 1935             


Arg Asn  Gln Asn Lys Glu Gly  Asp Gln Tyr Ile Tyr  Met Gly Gln 
    1940                 1945                 1950             


Pro Leu  Asn Asn Asp Glu Asp  His Ala His Trp Thr  Glu Ala Lys 
    1955                 1960                 1965             


Met Leu  Leu Asp Asn Ile Asn  Thr Pro Glu Gly Ile  Ile Pro Ala 
    1970                 1975                 1980             


Leu Tyr  Glu Pro Glu Arg Glu  Lys Ser Ala Ala Ile  Asp Gly Glu 
    1985                 1990                 1995             


Tyr Arg  Leu Arg Gly Glu Ala  Arg Lys Thr Phe Val  Glu Leu Met 
    2000                 2005                 2010             


Arg Arg  Gly Asp Leu Pro Val  Trp Leu Ser Tyr Lys  Val Ala Ser 
    2015                 2020                 2025             


Glu Gly  Phe Gln Tyr Ser Asp  Arg Arg Trp Cys Phe  Asp Gly Glu 
    2030                 2035                 2040             


Arg Asn  Asn Gln Val Leu Glu  Glu Asn Met Asp Val  Glu Ile Trp 
    2045                 2050                 2055             


Thr Lys  Glu Gly Glu Arg Lys  Lys Leu Arg Pro Arg  Trp Leu Asp 
    2060                 2065                 2070             


Ala Arg  Thr Tyr Ser Asp Pro  Leu Ala Leu Arg Glu  Phe Lys Glu 
    2075                 2080                 2085             


Phe Ala  Ala Gly Arg Arg Ser  Val Ser Gly Asp Leu  Ile Leu Glu 
    2090                 2095                 2100             


Ile Gly  Lys Leu Pro Gln His  Leu Thr Gln Arg Ala  Gln Asn Ala 
    2105                 2110                 2115             


Leu Asp  Asn Leu Val Met Leu  His Asn Ser Glu Gln  Gly Gly Lys 
    2120                 2125                 2130             


Ala Tyr  Arg His Ala Met Glu  Glu Leu Pro Asp Thr  Ile Glu Thr 
    2135                 2140                 2145             


Leu Met  Leu Leu Ala Leu Ile  Ala Val Leu Thr Gly  Gly Val Thr 
    2150                 2155                 2160             


Leu Phe  Phe Leu Ser Gly Arg  Gly Leu Gly Lys Thr  Ser Ile Gly 
    2165                 2170                 2175             


Leu Leu  Cys Val Met Ala Ser  Ser Ala Leu Leu Trp  Met Ala Ser 
    2180                 2185                 2190             


Val Glu  Pro His Trp Ile Ala  Ala Ser Ile Ile Leu  Glu Phe Phe 
    2195                 2200                 2205             


Leu Met  Val Leu Leu Ile Pro  Glu Pro Asp Arg Gln  Arg Thr Pro 
    2210                 2215                 2220             


Gln Asp  Asn Gln Leu Ala Tyr  Val Val Ile Gly Leu  Leu Phe Met 
    2225                 2230                 2235             


Ile Leu  Thr Val Ala Ala Asn  Glu Met Gly Leu Leu  Glu Thr Thr 
    2240                 2245                 2250             


Lys Lys  Asp Leu Gly Ile Gly  His Val Ala Ala Glu  Asn His His 
    2255                 2260                 2265             


His Ala  Thr Met Leu Asp Val  Asp Leu His Pro Ala  Ser Ala Trp 
    2270                 2275                 2280             


Thr Leu  Tyr Ala Val Ala Thr  Thr Ile Ile Thr Pro  Met Met Arg 
    2285                 2290                 2295             


His Thr  Ile Glu Asn Thr Thr  Ala Asn Ile Ser Leu  Thr Ala Ile 
    2300                 2305                 2310             


Ala Asn  Gln Ala Ala Ile Leu  Met Gly Leu Asp Lys  Gly Trp Pro 
    2315                 2320                 2325             


Ile Ser  Lys Met Asp Ile Gly  Val Pro Leu Leu Ala  Leu Gly Cys 
    2330                 2335                 2340             


Tyr Ser  Gln Val Asn Pro Leu  Thr Leu Ile Ala Ala  Val Leu Met 
    2345                 2350                 2355             


Leu Val  Ala His Tyr Ala Ile  Ile Gly Pro Gly Leu  Gln Ala Lys 
    2360                 2365                 2370             


Ala Thr  Arg Glu Ala Gln Lys  Arg Thr Ala Ala Gly  Ile Met Lys 
    2375                 2380                 2385             


Asn Pro  Thr Val Asp Gly Ile  Val Ala Ile Asp Leu  Asp Pro Val 
    2390                 2395                 2400             


Val Tyr  Asp Ala Lys Phe Glu  Lys Gln Leu Gly Gln  Ile Met Leu 
    2405                 2410                 2415             


Leu Ile  Leu Cys Thr Ser Gln  Ile Leu Leu Met Arg  Thr Thr Trp 
    2420                 2425                 2430             


Ala Leu  Cys Glu Ser Ile Thr  Leu Ala Thr Gly Pro  Leu Thr Thr 
    2435                 2440                 2445             


Leu Trp  Glu Gly Ser Pro Gly  Lys Phe Trp Asn Thr  Thr Ile Ala 
    2450                 2455                 2460             


Val Ser  Met Ala Asn Ile Phe  Arg Gly Ser Tyr Leu  Ala Gly Ala 
    2465                 2470                 2475             


Gly Leu  Ala Phe Ser Leu Met  Lys Ser Leu Gly Gly  Gly Arg Arg 
    2480                 2485                 2490             


Gly Thr  Gly Ala Gln Gly Glu  Thr Leu Gly Glu Lys  Trp Lys Arg 
    2495                 2500                 2505             


Gln Leu  Asn Gln Leu Ser Lys  Ser Glu Phe Asn Thr  Tyr Lys Arg 
    2510                 2515                 2520             


Ser Gly  Ile Met Glu Val Asp  Arg Ser Glu Ala Lys  Glu Gly Leu 
    2525                 2530                 2535             


Lys Arg  Gly Glu Thr Thr Lys  His Ala Val Ser Arg  Gly Thr Ala 
    2540                 2545                 2550             


Lys Leu  Arg Trp Phe Val Glu  Arg Asn Leu Val Lys  Pro Glu Gly 
    2555                 2560                 2565             


Lys Val  Ile Asp Leu Gly Cys  Gly Arg Gly Gly Trp  Ser Tyr Tyr 
    2570                 2575                 2580             


Cys Ala  Gly Leu Lys Lys Val  Thr Glu Val Lys Gly  Tyr Thr Lys 
    2585                 2590                 2595             


Gly Gly  Pro Gly His Glu Glu  Pro Ile Pro Met Ala  Thr Tyr Gly 
    2600                 2605                 2610             


Trp Asn  Leu Val Lys Leu His  Ser Gly Lys Asp Val  Phe Phe Ile 
    2615                 2620                 2625             


Pro Pro  Glu Lys Cys Asp Thr  Leu Leu Cys Asp Ile  Gly Glu Ser 
    2630                 2635                 2640             


Ser Pro  Asn Pro Thr Ile Glu  Glu Gly Arg Thr Leu  Arg Val Leu 
    2645                 2650                 2655             


Lys Met  Val Glu Pro Trp Leu  Arg Gly Asn Gln Phe  Cys Ile Lys 
    2660                 2665                 2670             


Ile Leu  Asn Pro Tyr Met Pro  Ser Val Val Glu Thr  Leu Glu Gln 
    2675                 2680                 2685             


Met Gln  Arg Lys His Gly Gly  Met Leu Val Arg Asn  Pro Leu Ser 
    2690                 2695                 2700             


Arg Asn  Ser Thr His Glu Met  Tyr Trp Val Ser Cys  Gly Thr Gly 
    2705                 2710                 2715             


Asn Ile  Val Ser Ala Val Asn  Met Thr Ser Arg Met  Leu Leu Asn 
    2720                 2725                 2730             


Arg Phe  Thr Met Ala His Arg  Lys Pro Thr Tyr Glu  Arg Asp Val 
    2735                 2740                 2745             


Asp Leu  Gly Ala Gly Thr Arg  His Val Ala Val Glu  Pro Glu Val 
    2750                 2755                 2760             


Ala Asn  Leu Asp Ile Ile Gly  Gln Arg Ile Glu Asn  Ile Lys Asn 
    2765                 2770                 2775             


Glu His  Lys Ser Thr Trp His  Tyr Asp Glu Asp Asn  Pro Tyr Lys 
    2780                 2785                 2790             


Thr Trp  Ala Tyr His Gly Ser  Tyr Glu Val Lys Pro  Ser Gly Ser 
    2795                 2800                 2805             


Ala Ser  Ser Met Val Asn Gly  Val Val Arg Leu Leu  Thr Lys Pro 
    2810                 2815                 2820             


Trp Asp  Val Ile Pro Met Val  Thr Gln Ile Ala Met  Thr Asp Thr 
    2825                 2830                 2835             


Thr Pro  Phe Gly Gln Gln Arg  Val Phe Lys Glu Lys  Val Asp Thr 
    2840                 2845                 2850             


Arg Thr  Pro Lys Ala Lys Arg  Gly Thr Ala Gln Ile  Met Glu Val 
    2855                 2860                 2865             


Thr Ala  Arg Trp Leu Trp Gly  Phe Leu Ser Arg Asn  Lys Lys Pro 
    2870                 2875                 2880             


Arg Ile  Cys Thr Arg Glu Glu  Phe Thr Arg Lys Val  Arg Ser Asn 
    2885                 2890                 2895             


Ala Ala  Ile Gly Ala Val Phe  Val Asp Glu Asn Gln  Trp Asn Ser 
    2900                 2905                 2910             


Ala Lys  Glu Ala Val Glu Asp  Glu Arg Phe Trp Glu  Leu Val His 
    2915                 2920                 2925             


Arg Glu  Arg Glu Leu His Lys  Gln Gly Lys Cys Ala  Thr Cys Val 
    2930                 2935                 2940             


Tyr Asn  Met Met Gly Lys Arg  Glu Lys Lys Leu Gly  Glu Phe Gly 
    2945                 2950                 2955             


Lys Ala  Lys Gly Ser Arg Ala  Ile Trp Tyr Met Trp  Leu Gly Ala 
    2960                 2965                 2970             


Arg Phe  Leu Glu Phe Glu Ala  Leu Gly Phe Met Asn  Glu Asp His 
    2975                 2980                 2985             


Trp Phe  Ser Arg Glu Asn Ser  Leu Ser Gly Val Glu  Gly Glu Gly 
    2990                 2995                 3000             


Leu His  Lys Leu Gly Tyr Ile  Leu Arg Asp Ile Ser  Arg Ile Pro 
    3005                 3010                 3015             


Gly Gly  Asn Met Tyr Ala Asp  Asp Thr Ala Gly Trp  Asp Thr Arg 
    3020                 3025                 3030             


Ile Thr  Glu Asp Asp Leu Gln  Asn Glu Ala Lys Ile  Thr Asp Ile 
    3035                 3040                 3045             


Met Glu  Pro Glu His Ala Leu  Leu Ala Thr Ser Ile  Phe Lys Leu 
    3050                 3055                 3060             


Thr Tyr  Gln Asn Lys Val Val  Arg Val Gln Arg Pro  Ala Lys Asn 
    3065                 3070                 3075             


Gly Thr  Val Met Asp Val Ile  Ser Arg Arg Asp Gln  Arg Gly Ser 
    3080                 3085                 3090             


Gly Gln  Val Gly Thr Tyr Gly  Leu Asn Thr Phe Thr  Asn Met Glu 
    3095                 3100                 3105             


Ala Gln  Leu Ile Arg Gln Met  Glu Ser Glu Gly Ile  Phe Leu Pro 
    3110                 3115                 3120             


Ser Glu  Leu Glu Thr Pro Asn  Leu Ala Gly Arg Val  Leu Asp Trp 
    3125                 3130                 3135             


Leu Glu  Lys Tyr Gly Val Glu  Arg Leu Lys Arg Met  Ala Ile Ser 
    3140                 3145                 3150             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala Thr 
    3155                 3160                 3165             


Ala Leu  Thr Ala Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Ile 
    3170                 3175                 3180             


Pro Gln  Trp Glu Pro Ser Lys  Gly Trp Asn Asp Trp  Gln Gln Val 
    3185                 3190                 3195             


Pro Phe  Cys Ser His His Phe  His Gln Leu Ile Met  Lys Asp Gly 
    3200                 3205                 3210             


Arg Glu  Ile Val Val Pro Cys  Arg Asn Gln Asp Glu  Leu Val Gly 
    3215                 3220                 3225             


Arg Ala  Arg Val Ser Gln Gly  Ala Gly Trp Ser Leu  Arg Glu Thr 
    3230                 3235                 3240             


Ala Cys  Leu Gly Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Met Tyr 
    3245                 3250                 3255             


Phe His  Arg Arg Asp Leu Arg  Leu Ala Ala Asn Ala  Ile Cys Ser 
    3260                 3265                 3270             


Ala Val  Pro Val Asp Trp Val  Pro Thr Ser Arg Thr  Thr Trp Ser 
    3275                 3280                 3285             


Ile His  Ala His His Gln Trp  Met Thr Thr Glu Asp  Met Leu Ser 
    3290                 3295                 3300             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Pro Trp  Met Glu Asp 
    3305                 3310                 3315             


Lys Thr  His Val Ser Ser Trp  Glu Glu Val Pro Tyr  Leu Gly Lys 
    3320                 3325                 3330             


Arg Glu  Asp Gln Trp Cys Gly  Ser Leu Ile Gly Leu  Thr Ala Arg 
    3335                 3340                 3345             


Ala Thr  Trp Ala Thr Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg 
    3350                 3355                 3360             


Arg Leu  Ile Gly Asn Glu Asn  Tyr Leu Asp Tyr Met  Thr Ser Met 
    3365                 3370                 3375             


Lys Arg  Phe Lys Asn Glu Ser  Asp Pro Glu Gly Ala  Leu Trp 
    3380                 3385                 3390         


<210>  5
<211>  10723
<212>  DNA
<213>  Dengue virus type 2


<220>
<221>  CDS
<222>  (97)..(10272)

<400>  5
agttgttagt ctacgtggac cgacaaagac agattctttg agggagctaa gctcaacgta       60

gttctaacag ttttttaatt agagagcaga tctctg atg aat aac caa cgg aaa        114
                                        Met Asn Asn Gln Arg Lys           
                                        1               5                 

aag gcg aaa aac acg cct ttc aat atg ctg aaa cgc gag aga aac cgc        162
Lys Ala Lys Asn Thr Pro Phe Asn Met Leu Lys Arg Glu Arg Asn Arg           
            10                  15                  20                    

gtg tcg act gtg caa cag ctg aca aag aga ttc tca ctt gga atg ctg        210
Val Ser Thr Val Gln Gln Leu Thr Lys Arg Phe Ser Leu Gly Met Leu           
        25                  30                  35                        

cag gga cga gga cca tta aaa ctg ttc atg gcc ctg gtg gcg ttc ctt        258
Gln Gly Arg Gly Pro Leu Lys Leu Phe Met Ala Leu Val Ala Phe Leu           
    40                  45                  50                            

cgt ttc cta aca atc cca cca aca gca ggg ata ttg aag aga tgg gga        306
Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly Ile Leu Lys Arg Trp Gly           
55                  60                  65                  70            

aca att aaa aaa tca aaa gct att aat gtt ttg aga ggg ttc agg aaa        354
Thr Ile Lys Lys Ser Lys Ala Ile Asn Val Leu Arg Gly Phe Arg Lys           
                75                  80                  85                

gag att gga agg atg ctg aac atc ttg aat agg aga cgc aga tct gca        402
Glu Ile Gly Arg Met Leu Asn Ile Leu Asn Arg Arg Arg Arg Ser Ala           
            90                  95                  100                   

ggc atg atc att atg ctg att cca aca gtg atg gcg ttc cat tta acc        450
Gly Met Ile Ile Met Leu Ile Pro Thr Val Met Ala Phe His Leu Thr           
        105                 110                 115                       

aca cgt aac gga gaa cca cac atg atc gtc agc aga caa gag aaa ggg        498
Thr Arg Asn Gly Glu Pro His Met Ile Val Ser Arg Gln Glu Lys Gly           
    120                 125                 130                           

aaa agt ctt ctg ttt aaa aca gag gat ggc gtg aac atg tgt acc ctc        546
Lys Ser Leu Leu Phe Lys Thr Glu Asp Gly Val Asn Met Cys Thr Leu           
135                 140                 145                 150           

atg gcc atg gac ctt ggt gaa ttg tgt gaa gac aca atc acg tac aag        594
Met Ala Met Asp Leu Gly Glu Leu Cys Glu Asp Thr Ile Thr Tyr Lys           
                155                 160                 165               

tgt ccc ctt ctc agg cag aat gag cca gaa gac ata gac tgt tgg tgc        642
Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu Asp Ile Asp Cys Trp Cys           
            170                 175                 180                   

aac tct acg tcc acg tgg gta act tat ggg acg tgt acc acc atg gga        690
Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly Thr Cys Thr Thr Met Gly           
        185                 190                 195                       

gaa cat aga aga gaa aaa aga tca gtg gca ctc gtt cca cat gtg gga        738
Glu His Arg Arg Glu Lys Arg Ser Val Ala Leu Val Pro His Val Gly           
    200                 205                 210                           

atg gga ctg gag aca cga act gaa aca tgg atg tca tca gaa ggg gcc        786
Met Gly Leu Glu Thr Arg Thr Glu Thr Trp Met Ser Ser Glu Gly Ala           
215                 220                 225                 230           

tgg aaa cat gtc cag aga att gaa act tgg atc ttg aga cat cca ggc        834
Trp Lys His Val Gln Arg Ile Glu Thr Trp Ile Leu Arg His Pro Gly           
                235                 240                 245               

ttc acc atg atg gca gca atc ctg gca tac acc ata gga acg aca cat        882
Phe Thr Met Met Ala Ala Ile Leu Ala Tyr Thr Ile Gly Thr Thr His           
            250                 255                 260                   

ttc caa aga gcc ctg att ttc atc tta ctg aca gct gtc act cct tca        930
Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu Thr Ala Val Thr Pro Ser           
        265                 270                 275                       

atg aca atg cgt tgc ata gga atg tca aat aga gac ttt gtg gaa ggg        978
Met Thr Met Arg Cys Ile Gly Met Ser Asn Arg Asp Phe Val Glu Gly           
    280                 285                 290                           

gtt tca gga gga agc tgg gtt gac ata gtc tta gaa cat gga agc tgt       1026
Val Ser Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys           
295                 300                 305                 310           

gtg acg acg atg gca aaa aac aaa cca aca ttg gat ttt gaa ctg ata       1074
Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile           
                315                 320                 325               

aaa aca gaa gcc aaa cag cct gcc acc cta agg aag tac tgt ata gag       1122
Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu           
            330                 335                 340                   

gca aag cta acc aac aca aca aca gaa tct cgc tgc cca aca caa ggg       1170
Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly           
        345                 350                 355                       

gaa ccc agc cta aat gaa gag cag gac aaa agg ttc gtc tgc aaa cac       1218
Glu Pro Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His           
    360                 365                 370                           

tcc atg gta gac aga gga tgg gga aat gga tgt gga cta ttt gga aag       1266
Ser Met Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys           
375                 380                 385                 390           

gga ggc att gtg acc tgt gct atg ttc aga tgc aaa aag aac atg gaa       1314
Gly Gly Ile Val Thr Cys Ala Met Phe Arg Cys Lys Lys Asn Met Glu           
                395                 400                 405               

gga aaa gtt gtg caa cca gaa aac ttg gaa tac acc att gtg ata aca       1362
Gly Lys Val Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr           
            410                 415                 420                   

cct cac tca ggg gaa gag cat gca gtc gga aat gac aca gga aaa cat       1410
Pro His Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His           
        425                 430                 435                       

ggc aag gaa atc aaa ata aca cca cag agt tcc atc aca gaa gca gaa       1458
Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu           
    440                 445                 450                           

ttg aca ggt tat ggc act gtc aca atg gag tgc tct cca aga acg ggc       1506
Leu Thr Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly           
455                 460                 465                 470           

ctc gac ttc aat gag atg gtg ttg ctg cag atg gaa aat aaa gct tgg       1554
Leu Asp Phe Asn Glu Met Val Leu Leu Gln Met Glu Asn Lys Ala Trp           
                475                 480                 485               

ctg gtg cac agg caa tgg ttc cta gac ctg ccg tta cca tgg ttg ccc       1602
Leu Val His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro           
            490                 495                 500                   

gga gcg gac aca caa ggg tca aat tgg ata cag aaa gag aca ttg gtc       1650
Gly Ala Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val           
        505                 510                 515                       

act ttc aaa aat ccc cat gcg aag aaa cag gat gtt gtt gtt tta gga       1698
Thr Phe Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly           
    520                 525                 530                           

tcc caa gaa ggg gcc atg cac aca gca ctt aca ggg gcc aca gaa atc       1746
Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile           
535                 540                 545                 550           

caa atg tca tca gga aac tta ctc ttc aca gga cat ctc aag tgc agg       1794
Gln Met Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg           
                555                 560                 565               

ctg aga atg gac aag cta cag ctc aaa gga atg tca tac tct atg tgc       1842
Leu Arg Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys           
            570                 575                 580                   

aca gga aag ttt aaa gtt gtg aag gaa ata gca gaa aca caa cat gga       1890
Thr Gly Lys Phe Lys Val Val Lys Glu Ile Ala Glu Thr Gln His Gly           
        585                 590                 595                       

aca ata gtt atc aga gtg caa tat gaa ggg gac ggc tct cca tgc aag       1938
Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys           
    600                 605                 610                           

atc cct ttt gag ata atg gat ttg gaa aaa aga cat gtc tta ggt cgc       1986
Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg           
615                 620                 625                 630           

ctg att aca gtc aac cca att gtg aca gaa aaa gat agc cca gtc aac       2034
Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn           
                635                 640                 645               

ata gaa gca gaa cct cca ttc gga gac agc tac atc atc ata gga gta       2082
Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val           
            650                 655                 660                   

gag ccg gga caa ctg aag ctc aac tgg ttt aag aaa gga agt tct atc       2130
Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly Ser Ser Ile           
        665                 670                 675                       

ggc caa atg ttt gag aca aca atg agg ggg gcg aag aga atg gcc att       2178
Gly Gln Met Phe Glu Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile           
    680                 685                 690                           

tta ggt gac aca gcc tgg gat ttt gga tcc ttg gga gga gtg ttt aca       2226
Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr           
695                 700                 705                 710           

tct ata gga aag gct ctc cac caa gtc ttt gga gca atc tat gga gct       2274
Ser Ile Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala           
                715                 720                 725               

gcc ttc agt ggg gtt tca tgg act atg aaa atc ctc ata gga gtc att       2322
Ala Phe Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Ile           
            730                 735                 740                   

atc aca tgg ata gga atg aat tca cgc agc acc tca ctg tct gtg aca       2370
Ile Thr Trp Ile Gly Met Asn Ser Arg Ser Thr Ser Leu Ser Val Thr           
        745                 750                 755                       

cta gta ttg gtg gga att gtg aca ctg tat ttg gga gtc atg gtg cag       2418
Leu Val Leu Val Gly Ile Val Thr Leu Tyr Leu Gly Val Met Val Gln           
    760                 765                 770                           

gcc gat agt ggt tgc gtt gtg agc tgg aaa aac aaa gaa ctg aaa tgt       2466
Ala Asp Ser Gly Cys Val Val Ser Trp Lys Asn Lys Glu Leu Lys Cys           
775                 780                 785                 790           

ggc agt ggg att ttc atc aca gac aac gtg cac aca tgg aca gaa caa       2514
Gly Ser Gly Ile Phe Ile Thr Asp Asn Val His Thr Trp Thr Glu Gln           
                795                 800                 805               

tac aag ttc caa cca gaa tcc cct tca aaa cta gct tca gct atc cag       2562
Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys Leu Ala Ser Ala Ile Gln           
            810                 815                 820                   

aaa gcc cat gaa gag ggc att tgt gga atc cgc tca gta aca aga ctg       2610
Lys Ala His Glu Glu Gly Ile Cys Gly Ile Arg Ser Val Thr Arg Leu           
        825                 830                 835                       

gag aat ctg atg tgg aaa caa ata aca cca gaa ttg aat cac att cta       2658
Glu Asn Leu Met Trp Lys Gln Ile Thr Pro Glu Leu Asn His Ile Leu           
    840                 845                 850                           

tca gaa aat gag gtg aag tta act att atg aca gga gac atc aaa gga       2706
Ser Glu Asn Glu Val Lys Leu Thr Ile Met Thr Gly Asp Ile Lys Gly           
855                 860                 865                 870           

atc atg cag gca gga aaa cga tct ctg cgg cct cag ccc act gag ctg       2754
Ile Met Gln Ala Gly Lys Arg Ser Leu Arg Pro Gln Pro Thr Glu Leu           
                875                 880                 885               

aag tat tca tgg aaa aca tgg ggc aaa gca aaa atg ctc tct aca gag       2802
Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys Met Leu Ser Thr Glu           
            890                 895                 900                   

tct cat aac cag acc ttt ctc att gat ggc ccc gaa aca gca gaa tgc       2850
Ser His Asn Gln Thr Phe Leu Ile Asp Gly Pro Glu Thr Ala Glu Cys           
        905                 910                 915                       

ccc aac aca aat aga gct tgg aat tcg ttg gaa gtt gaa gac tat ggc       2898
Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu Glu Val Glu Asp Tyr Gly           
    920                 925                 930                           

ttt gga gta ttc acc acc aat ata tgg cta aaa ttg aaa gaa aaa cag       2946
Phe Gly Val Phe Thr Thr Asn Ile Trp Leu Lys Leu Lys Glu Lys Gln           
935                 940                 945                 950           

gat gta ttc tgc gac tca aaa ctc atg tca gcg gcc ata aaa gac aac       2994
Asp Val Phe Cys Asp Ser Lys Leu Met Ser Ala Ala Ile Lys Asp Asn           
                955                 960                 965               

aga gcc gtc cat gcc gat atg ggt tat tgg ata gaa agt gca ctc aat       3042
Arg Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu Ser Ala Leu Asn           
            970                 975                 980                   

gac aca tgg aag ata gag aaa gcc tct ttc att gaa gtt aaa aac tgc       3090
Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe Ile Glu Val Lys Asn Cys           
        985                 990                 995                       

cac tgg  cca aaa tca cac acc  ctc tgg agc aat gga  gtg cta gaa        3135
His Trp  Pro Lys Ser His Thr  Leu Trp Ser Asn Gly  Val Leu Glu            
    1000                 1005                 1010                        

agt gag  atg ata att cca aag  aat ctc gct gga cca  gtg tct caa        3180
Ser Glu  Met Ile Ile Pro Lys  Asn Leu Ala Gly Pro  Val Ser Gln            
    1015                 1020                 1025                        

cac aac  tat aga cca ggc tac  cat aca caa ata aca  gga cca tgg        3225
His Asn  Tyr Arg Pro Gly Tyr  His Thr Gln Ile Thr  Gly Pro Trp            
    1030                 1035                 1040                        

cat cta  ggt aag ctt gag atg  gac ttt gat ttc tgt  gat gga aca        3270
His Leu  Gly Lys Leu Glu Met  Asp Phe Asp Phe Cys  Asp Gly Thr            
    1045                 1050                 1055                        

aca gtg  gta gtg act gag gac  tgc gga aat aga gga  ccc tct ttg        3315
Thr Val  Val Val Thr Glu Asp  Cys Gly Asn Arg Gly  Pro Ser Leu            
    1060                 1065                 1070                        

aga aca  acc act gcc tct gga  aaa ctc ata aca gaa  tgg tgc tgc        3360
Arg Thr  Thr Thr Ala Ser Gly  Lys Leu Ile Thr Glu  Trp Cys Cys            
    1075                 1080                 1085                        

cga tct  tgc aca tta cca ccg  cta aga tac aga ggt  gag gat ggg        3405
Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr Arg Gly  Glu Asp Gly            
    1090                 1095                 1100                        

tgc tgg  tac ggg atg gaa atc  aga cca ttg aag gag  aaa gaa gag        3450
Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Leu Lys Glu  Lys Glu Glu            
    1105                 1110                 1115                        

aat ttg  gtc aac tcc ttg gtc  aca gct gga cat ggg  cag gtc gac        3495
Asn Leu  Val Asn Ser Leu Val  Thr Ala Gly His Gly  Gln Val Asp            
    1120                 1125                 1130                        

aac ttt  tca cta gga gtc ttg  gga atg gca ttg ttc  ctg gag gaa        3540
Asn Phe  Ser Leu Gly Val Leu  Gly Met Ala Leu Phe  Leu Glu Glu            
    1135                 1140                 1145                        

atg ctt  agg acc cga gta gga  acg aaa cat gca ata  cta cta gtt        3585
Met Leu  Arg Thr Arg Val Gly  Thr Lys His Ala Ile  Leu Leu Val            
    1150                 1155                 1160                        

gca gtt  tct ttt gtg aca ttg  atc aca ggg aac atg  tcc ttt aga        3630
Ala Val  Ser Phe Val Thr Leu  Ile Thr Gly Asn Met  Ser Phe Arg            
    1165                 1170                 1175                        

gac ctg  gga aga gtg atg gtt  atg gta ggc gcc act  atg acg gat        3675
Asp Leu  Gly Arg Val Met Val  Met Val Gly Ala Thr  Met Thr Asp            
    1180                 1185                 1190                        

gac ata  ggt atg ggc gtg act  tat ctt gcc cta cta  gca gcc ttc        3720
Asp Ile  Gly Met Gly Val Thr  Tyr Leu Ala Leu Leu  Ala Ala Phe            
    1195                 1200                 1205                        

aaa gtc  aga cca act ttt gca  gct gga cta ctc ttg  aga aag ctg        3765
Lys Val  Arg Pro Thr Phe Ala  Ala Gly Leu Leu Leu  Arg Lys Leu            
    1210                 1215                 1220                        

acc tcc  aag gaa ttg atg atg  act act ata gga att  gta ctc ctc        3810
Thr Ser  Lys Glu Leu Met Met  Thr Thr Ile Gly Ile  Val Leu Leu            
    1225                 1230                 1235                        

tcc cag  agc acc ata cca gag  acc att ctt gag ttg  act gat gcg        3855
Ser Gln  Ser Thr Ile Pro Glu  Thr Ile Leu Glu Leu  Thr Asp Ala            
    1240                 1245                 1250                        

tta gcc  tta ggc atg atg gtc  ctc aaa atg gtg aga  aat atg gaa        3900
Leu Ala  Leu Gly Met Met Val  Leu Lys Met Val Arg  Asn Met Glu            
    1255                 1260                 1265                        

aag tat  caa ttg gca gtg act  atc atg gct atc ttg  tgc gtc cca        3945
Lys Tyr  Gln Leu Ala Val Thr  Ile Met Ala Ile Leu  Cys Val Pro            
    1270                 1275                 1280                        

aac gca  gtg ata tta caa aac  gca tgg aaa gtg agt  tgc aca ata        3990
Asn Ala  Val Ile Leu Gln Asn  Ala Trp Lys Val Ser  Cys Thr Ile            
    1285                 1290                 1295                        

ttg gca  gtg gtg tcc gtt tcc  cca ctg ctc tta aca  tcc tca cag        4035
Leu Ala  Val Val Ser Val Ser  Pro Leu Leu Leu Thr  Ser Ser Gln            
    1300                 1305                 1310                        

caa aaa  aca gat tgg ata cca  tta gca ttg acg atc  aaa ggt ctc        4080
Gln Lys  Thr Asp Trp Ile Pro  Leu Ala Leu Thr Ile  Lys Gly Leu            
    1315                 1320                 1325                        

aat cca  aca gct att ttt cta  aca acc ctc tca aga  acc agc aag        4125
Asn Pro  Thr Ala Ile Phe Leu  Thr Thr Leu Ser Arg  Thr Ser Lys            
    1330                 1335                 1340                        

aaa agg  agc tgg cca tta aat  gag gct atc atg gca  gtc ggg atg        4170
Lys Arg  Ser Trp Pro Leu Asn  Glu Ala Ile Met Ala  Val Gly Met            
    1345                 1350                 1355                        

gtg agc  att tta gcc agt tct  ctc cta aaa aat gat  att ccc atg        4215
Val Ser  Ile Leu Ala Ser Ser  Leu Leu Lys Asn Asp  Ile Pro Met            
    1360                 1365                 1370                        

aca gga  cca tta gtg gct gga  ggg ctc ctc act gtg  tgc tac gtg        4260
Thr Gly  Pro Leu Val Ala Gly  Gly Leu Leu Thr Val  Cys Tyr Val            
    1375                 1380                 1385                        

ctc act  gga cga tcg gcc gat  ttg gaa ctg gag aga  gca gcc gat        4305
Leu Thr  Gly Arg Ser Ala Asp  Leu Glu Leu Glu Arg  Ala Ala Asp            
    1390                 1395                 1400                        

gtc aaa  tgg gaa gac cag gca  gag ata tca gga agc  agt cca atc        4350
Val Lys  Trp Glu Asp Gln Ala  Glu Ile Ser Gly Ser  Ser Pro Ile            
    1405                 1410                 1415                        

ctg tca  ata aca ata tca gaa  gat ggt agc atg tcg  ata aaa aat        4395
Leu Ser  Ile Thr Ile Ser Glu  Asp Gly Ser Met Ser  Ile Lys Asn            
    1420                 1425                 1430                        

gaa gag  gaa gaa caa aca ctg  acc ata ctc att aga  aca gga ttg        4440
Glu Glu  Glu Glu Gln Thr Leu  Thr Ile Leu Ile Arg  Thr Gly Leu            
    1435                 1440                 1445                        

ctg gtg  atc tca gga ctt ttt  cct gta tca ata cca  atc acg gca        4485
Leu Val  Ile Ser Gly Leu Phe  Pro Val Ser Ile Pro  Ile Thr Ala            
    1450                 1455                 1460                        

gca gca  tgg tac ctg tgg gaa  gtg aag aaa caa cgg  gcc gga gta        4530
Ala Ala  Trp Tyr Leu Trp Glu  Val Lys Lys Gln Arg  Ala Gly Val            
    1465                 1470                 1475                        

ttg tgg  gat gtt cct tca ccc  cca ccc atg gga aag  gct gaa ctg        4575
Leu Trp  Asp Val Pro Ser Pro  Pro Pro Met Gly Lys  Ala Glu Leu            
    1480                 1485                 1490                        

gaa gat  gga gcc tat aga att  aag caa aaa ggg att  ctt gga tat        4620
Glu Asp  Gly Ala Tyr Arg Ile  Lys Gln Lys Gly Ile  Leu Gly Tyr            
    1495                 1500                 1505                        

tcc cag  atc gga gcc gga gtt  tac aaa gaa gga aca  ttc cat aca        4665
Ser Gln  Ile Gly Ala Gly Val  Tyr Lys Glu Gly Thr  Phe His Thr            
    1510                 1515                 1520                        

atg tgg  cat gtc aca cgt ggc  gct gtt cta atg cat  aaa gga aag        4710
Met Trp  His Val Thr Arg Gly  Ala Val Leu Met His  Lys Gly Lys            
    1525                 1530                 1535                        

agg att  gaa cca tca tgg gcg  gac gtc aag aaa gac  cta ata tca        4755
Arg Ile  Glu Pro Ser Trp Ala  Asp Val Lys Lys Asp  Leu Ile Ser            
    1540                 1545                 1550                        

tat gga  gga ggc tgg aag tta  gaa gga gaa tgg aag  gaa gga gaa        4800
Tyr Gly  Gly Gly Trp Lys Leu  Glu Gly Glu Trp Lys  Glu Gly Glu            
    1555                 1560                 1565                        

gaa gtc  cag gta ttg gca ctg  gag cct gga aaa aat  cca aga gcc        4845
Glu Val  Gln Val Leu Ala Leu  Glu Pro Gly Lys Asn  Pro Arg Ala            
    1570                 1575                 1580                        

gtc caa  acg aaa cct ggt ctt  ttc aaa acc aac gcc  gga aca ata        4890
Val Gln  Thr Lys Pro Gly Leu  Phe Lys Thr Asn Ala  Gly Thr Ile            
    1585                 1590                 1595                        

ggt gct  gta tct ctg gac ttt  tct cct gga acg tca  gga tct cca        4935
Gly Ala  Val Ser Leu Asp Phe  Ser Pro Gly Thr Ser  Gly Ser Pro            
    1600                 1605                 1610                        

att atc  gac aaa aaa gga aaa  gtt gtg ggt ctt tat  ggt aat ggt        4980
Ile Ile  Asp Lys Lys Gly Lys  Val Val Gly Leu Tyr  Gly Asn Gly            
    1615                 1620                 1625                        

gtt gtt  aca agg agt gga gca  tat gtg agt gct ata  gcc cag act        5025
Val Val  Thr Arg Ser Gly Ala  Tyr Val Ser Ala Ile  Ala Gln Thr            
    1630                 1635                 1640                        

gaa aaa  agc att gaa gac aac  cca gag atc gaa gat  gac att ttc        5070
Glu Lys  Ser Ile Glu Asp Asn  Pro Glu Ile Glu Asp  Asp Ile Phe            
    1645                 1650                 1655                        

cga aag  aga aga ctg acc atc  atg gac ctc cac cca  gga gcg gga        5115
Arg Lys  Arg Arg Leu Thr Ile  Met Asp Leu His Pro  Gly Ala Gly            
    1660                 1665                 1670                        

aag acg  aag aga tac ctt ccg  gcc ata gtc aga gaa  gct ata aaa        5160
Lys Thr  Lys Arg Tyr Leu Pro  Ala Ile Val Arg Glu  Ala Ile Lys            
    1675                 1680                 1685                        

cgg ggt  ttg aga aca tta atc  ttg gcc ccc act aga  gtt gtg gca        5205
Arg Gly  Leu Arg Thr Leu Ile  Leu Ala Pro Thr Arg  Val Val Ala            
    1690                 1695                 1700                        

gct gaa  atg gag gaa gcc ctt  aga gga ctt cca ata  aga tac cag        5250
Ala Glu  Met Glu Glu Ala Leu  Arg Gly Leu Pro Ile  Arg Tyr Gln            
    1705                 1710                 1715                        

acc cca  gcc atc aga gct gag  cac acc ggg cgg gag  att gtg gac        5295
Thr Pro  Ala Ile Arg Ala Glu  His Thr Gly Arg Glu  Ile Val Asp            
    1720                 1725                 1730                        

cta atg  tgt cat gcc aca ttt  acc atg agg ctg cta  tca cca gtt        5340
Leu Met  Cys His Ala Thr Phe  Thr Met Arg Leu Leu  Ser Pro Val            
    1735                 1740                 1745                        

aga gtg  cca aac tac aac ctg  att atc atg gac gaa  gcc cat ttc        5385
Arg Val  Pro Asn Tyr Asn Leu  Ile Ile Met Asp Glu  Ala His Phe            
    1750                 1755                 1760                        

aca gac  cca gca agt ata gca  gct aga gga tac atc  tca act cga        5430
Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly Tyr Ile  Ser Thr Arg            
    1765                 1770                 1775                        

gtg gag  atg ggt gag gca gct  ggg att ttt atg aca  gcc act ccc        5475
Val Glu  Met Gly Glu Ala Ala  Gly Ile Phe Met Thr  Ala Thr Pro            
    1780                 1785                 1790                        

ccg gga  agc aga gac cca ttt  cct cag agc aat gca  cca atc ata        5520
Pro Gly  Ser Arg Asp Pro Phe  Pro Gln Ser Asn Ala  Pro Ile Ile            
    1795                 1800                 1805                        

gat gaa  gaa aga gaa atc cct  gaa cgt tcg tgg aat  tcc gga cat        5565
Asp Glu  Glu Arg Glu Ile Pro  Glu Arg Ser Trp Asn  Ser Gly His            
    1810                 1815                 1820                        

gaa tgg  gtc acg gat ttt aaa  ggg aag act gtt tgg  ttc gtt cca        5610
Glu Trp  Val Thr Asp Phe Lys  Gly Lys Thr Val Trp  Phe Val Pro            
    1825                 1830                 1835                        

agt ata  aaa gca gga aat gat  ata gca gct tgc ctg  agg aaa aat        5655
Ser Ile  Lys Ala Gly Asn Asp  Ile Ala Ala Cys Leu  Arg Lys Asn            
    1840                 1845                 1850                        

gga aag  aaa gtg ata caa ctc  agt agg aag acc ttt  gat tct gag        5700
Gly Lys  Lys Val Ile Gln Leu  Ser Arg Lys Thr Phe  Asp Ser Glu            
    1855                 1860                 1865                        

tat gtc  aag act aga acc aat  gat tgg gac ttc gtg  gtt aca act        5745
Tyr Val  Lys Thr Arg Thr Asn  Asp Trp Asp Phe Val  Val Thr Thr            
    1870                 1875                 1880                        

gac att  tca gaa atg ggt gcc  aat ttc aag gct gag  agg gtt ata        5790
Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys Ala Glu  Arg Val Ile            
    1885                 1890                 1895                        

gac ccc  aga cgc tgc atg aaa  cca gtc ata cta aca  gat ggt gaa        5835
Asp Pro  Arg Arg Cys Met Lys  Pro Val Ile Leu Thr  Asp Gly Glu            
    1900                 1905                 1910                        

gag cgg  gtg att ctg gca gga  cct atg cca gtg acc  cac tct agt        5880
Glu Arg  Val Ile Leu Ala Gly  Pro Met Pro Val Thr  His Ser Ser            
    1915                 1920                 1925                        

gca gca  caa aga aga ggg aga  ata gga aga aat cca  aaa aat gag        5925
Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg Asn Pro  Lys Asn Glu            
    1930                 1935                 1940                        

aat gac  cag tac ata tac atg  ggg gaa cct ctg gaa  aat gat gaa        5970
Asn Asp  Gln Tyr Ile Tyr Met  Gly Glu Pro Leu Glu  Asn Asp Glu            
    1945                 1950                 1955                        

gac tgt  gca cac tgg aaa gaa  gct aaa atg ctc cta  gat aac atc        6015
Asp Cys  Ala His Trp Lys Glu  Ala Lys Met Leu Leu  Asp Asn Ile            
    1960                 1965                 1970                        

aac acg  cca gaa gga atc att  cct agc atg ttc gaa  cca gag cgt        6060
Asn Thr  Pro Glu Gly Ile Ile  Pro Ser Met Phe Glu  Pro Glu Arg            
    1975                 1980                 1985                        

gaa aag  gtg gat gcc att gat  ggc gaa tac cgc ttg  aga gga gaa        6105
Glu Lys  Val Asp Ala Ile Asp  Gly Glu Tyr Arg Leu  Arg Gly Glu            
    1990                 1995                 2000                        

gca agg  aaa acc ttt gta gac  tta atg aga aga gga  gac cta cca        6150
Ala Arg  Lys Thr Phe Val Asp  Leu Met Arg Arg Gly  Asp Leu Pro            
    2005                 2010                 2015                        

gtc tgg  ttg gcc tac aga gtg  gca gct gaa ggc atc  aac tac gca        6195
Val Trp  Leu Ala Tyr Arg Val  Ala Ala Glu Gly Ile  Asn Tyr Ala            
    2020                 2025                 2030                        

gac aga  agg tgg tgt ttt gat  gga gtc aag aac aac  caa atc cta        6240
Asp Arg  Arg Trp Cys Phe Asp  Gly Val Lys Asn Asn  Gln Ile Leu            
    2035                 2040                 2045                        

gaa gaa  aac gtg gaa gtt gaa  atc tgg aca aaa gaa  ggg gaa agg        6285
Glu Glu  Asn Val Glu Val Glu  Ile Trp Thr Lys Glu  Gly Glu Arg            
    2050                 2055                 2060                        

aag aaa  ttg aaa ccc aga tgg  ttg gat gct agg atc  tat tct gac        6330
Lys Lys  Leu Lys Pro Arg Trp  Leu Asp Ala Arg Ile  Tyr Ser Asp            
    2065                 2070                 2075                        

cca ctg  gcg cta aaa gaa ttt  aag gaa ttt gca gcc  gga aga aag        6375
Pro Leu  Ala Leu Lys Glu Phe  Lys Glu Phe Ala Ala  Gly Arg Lys            
    2080                 2085                 2090                        

tct ctg  acc ctg aac cta atc  aca gaa atg ggt agg  ctc cca acc        6420
Ser Leu  Thr Leu Asn Leu Ile  Thr Glu Met Gly Arg  Leu Pro Thr            
    2095                 2100                 2105                        

ttc atg  act cag aag gca aga  gac gca ctg gac aac  tta gca gtg        6465
Phe Met  Thr Gln Lys Ala Arg  Asp Ala Leu Asp Asn  Leu Ala Val            
    2110                 2115                 2120                        

ctg cac  acg gct gag gca ggt  gga agg gcg tac aac  cat gct ctc        6510
Leu His  Thr Ala Glu Ala Gly  Gly Arg Ala Tyr Asn  His Ala Leu            
    2125                 2130                 2135                        

agt gaa  ctg ccg gag acc ctg  gag aca ttg ctt tta  ctg aca ctt        6555
Ser Glu  Leu Pro Glu Thr Leu  Glu Thr Leu Leu Leu  Leu Thr Leu            
    2140                 2145                 2150                        

ctg gct  aca gtc acg gga ggg  atc ttt tta ttc ttg  atg agc gga        6600
Leu Ala  Thr Val Thr Gly Gly  Ile Phe Leu Phe Leu  Met Ser Gly            
    2155                 2160                 2165                        

agg ggc  ata ggg aag atg acc  ctg gga atg tgc tgc  ata atc acg        6645
Arg Gly  Ile Gly Lys Met Thr  Leu Gly Met Cys Cys  Ile Ile Thr            
    2170                 2175                 2180                        

gct agc  atc ctc cta tgg tac  gca caa ata cag cca  cac tgg ata        6690
Ala Ser  Ile Leu Leu Trp Tyr  Ala Gln Ile Gln Pro  His Trp Ile            
    2185                 2190                 2195                        

gca gct  tca ata ata ctg gag  ttt ttt ctc ata gtt  ttg ctt att        6735
Ala Ala  Ser Ile Ile Leu Glu  Phe Phe Leu Ile Val  Leu Leu Ile            
    2200                 2205                 2210                        

cca gaa  cct gaa aaa cag aga  aca ccc caa gac aac  caa ctg acc        6780
Pro Glu  Pro Glu Lys Gln Arg  Thr Pro Gln Asp Asn  Gln Leu Thr            
    2215                 2220                 2225                        

tac gtt  gtc ata gcc atc ctc  aca gtg gtg gcc gca  acc atg gca        6825
Tyr Val  Val Ile Ala Ile Leu  Thr Val Val Ala Ala  Thr Met Ala            
    2230                 2235                 2240                        

aac gag  atg ggt ttc cta gaa  aaa acg aag aaa gat  ctc gga ttg        6870
Asn Glu  Met Gly Phe Leu Glu  Lys Thr Lys Lys Asp  Leu Gly Leu            
    2245                 2250                 2255                        

gga agc  att gca acc cag caa  ccc gag agc aac atc  ctg gac ata        6915
Gly Ser  Ile Ala Thr Gln Gln  Pro Glu Ser Asn Ile  Leu Asp Ile            
    2260                 2265                 2270                        

gat cta  cgt cct gca tca gca  tgg acg ctg tat gcc  gtg gcc aca        6960
Asp Leu  Arg Pro Ala Ser Ala  Trp Thr Leu Tyr Ala  Val Ala Thr            
    2275                 2280                 2285                        

aca ttt  gtt aca cca atg ttg  aga cat agc att gaa  aat tcc tca        7005
Thr Phe  Val Thr Pro Met Leu  Arg His Ser Ile Glu  Asn Ser Ser            
    2290                 2295                 2300                        

gtg aat  gtg tcc cta aca gct  ata gcc aac caa gcc  aca gtg tta        7050
Val Asn  Val Ser Leu Thr Ala  Ile Ala Asn Gln Ala  Thr Val Leu            
    2305                 2310                 2315                        

atg ggt  ctc ggg aaa gga tgg  cca ttg tca aag atg  gac atc gga        7095
Met Gly  Leu Gly Lys Gly Trp  Pro Leu Ser Lys Met  Asp Ile Gly            
    2320                 2325                 2330                        

gtt ccc  ctt ctc gcc att gga  tgc tac tca caa gtc  aac ccc ata        7140
Val Pro  Leu Leu Ala Ile Gly  Cys Tyr Ser Gln Val  Asn Pro Ile            
    2335                 2340                 2345                        

act ctc  aca gca gct ctt ttc  tta ttg gta gca cat  tat gcc atc        7185
Thr Leu  Thr Ala Ala Leu Phe  Leu Leu Val Ala His  Tyr Ala Ile            
    2350                 2355                 2360                        

ata ggg  cca gga ctc caa gca  aaa gca acc aga gaa  gct cag aaa        7230
Ile Gly  Pro Gly Leu Gln Ala  Lys Ala Thr Arg Glu  Ala Gln Lys            
    2365                 2370                 2375                        

aga gca  gcg gcg ggc atc atg  aaa aac cca act gtc  gat gga ata        7275
Arg Ala  Ala Ala Gly Ile Met  Lys Asn Pro Thr Val  Asp Gly Ile            
    2380                 2385                 2390                        

aca gtg  att gac cta gat cca  ata cct tat gat cca  aag ttt gaa        7320
Thr Val  Ile Asp Leu Asp Pro  Ile Pro Tyr Asp Pro  Lys Phe Glu            
    2395                 2400                 2405                        

aag cag  ttg gga caa gta atg  ctc cta gtc ctc tgc  gtg act caa        7365
Lys Gln  Leu Gly Gln Val Met  Leu Leu Val Leu Cys  Val Thr Gln            
    2410                 2415                 2420                        

gta ttg  atg atg agg act aca  tgg gct ctg tgt gag  gct tta acc        7410
Val Leu  Met Met Arg Thr Thr  Trp Ala Leu Cys Glu  Ala Leu Thr            
    2425                 2430                 2435                        

tta gct  acc ggg ccc atc tcc  aca ttg tgg gaa gga  aat cca ggg        7455
Leu Ala  Thr Gly Pro Ile Ser  Thr Leu Trp Glu Gly  Asn Pro Gly            
    2440                 2445                 2450                        

agg ttt  tgg aac act acc att  gcg gtg tca atg gct  aac att ttt        7500
Arg Phe  Trp Asn Thr Thr Ile  Ala Val Ser Met Ala  Asn Ile Phe            
    2455                 2460                 2465                        

aga ggg  agt tac ttg gcc gga  gct gga ctt ctc ttt  tct att atg        7545
Arg Gly  Ser Tyr Leu Ala Gly  Ala Gly Leu Leu Phe  Ser Ile Met            
    2470                 2475                 2480                        

aag aac  aca acc aac aca aga  agg gga act ggc aac  ata gga gag        7590
Lys Asn  Thr Thr Asn Thr Arg  Arg Gly Thr Gly Asn  Ile Gly Glu            
    2485                 2490                 2495                        

acg ctt  gga gag aaa tgg aaa  agc cga ttg aac gca  ttg gga aaa        7635
Thr Leu  Gly Glu Lys Trp Lys  Ser Arg Leu Asn Ala  Leu Gly Lys            
    2500                 2505                 2510                        

agt gaa  ttc cag atc tac aag  aaa agt gga atc cag  gaa gtg gat        7680
Ser Glu  Phe Gln Ile Tyr Lys  Lys Ser Gly Ile Gln  Glu Val Asp            
    2515                 2520                 2525                        

aga acc  tta gca aaa gaa ggc  att aaa aga gga gaa  acg gac cat        7725
Arg Thr  Leu Ala Lys Glu Gly  Ile Lys Arg Gly Glu  Thr Asp His            
    2530                 2535                 2540                        

cac gct  gtg tcg cga ggc tca  gca aaa ctg aga tgg  ttc gtt gag        7770
His Ala  Val Ser Arg Gly Ser  Ala Lys Leu Arg Trp  Phe Val Glu            
    2545                 2550                 2555                        

aga aac  atg gtc aca cca gaa  ggg aaa gta gtg gac  ctc ggt tgt        7815
Arg Asn  Met Val Thr Pro Glu  Gly Lys Val Val Asp  Leu Gly Cys            
    2560                 2565                 2570                        

ggc aga  gga ggc tgg tca tac  tat tgt gga gga cta  aag aat gta        7860
Gly Arg  Gly Gly Trp Ser Tyr  Tyr Cys Gly Gly Leu  Lys Asn Val            
    2575                 2580                 2585                        

aga gaa  gtc aaa ggc cta aca  aaa gga gga cca gga  cac gaa gaa        7905
Arg Glu  Val Lys Gly Leu Thr  Lys Gly Gly Pro Gly  His Glu Glu            
    2590                 2595                 2600                        

ccc atc  ccc atg tca aca tat  ggg tgg aat cta gtg  cgt ctt caa        7950
Pro Ile  Pro Met Ser Thr Tyr  Gly Trp Asn Leu Val  Arg Leu Gln            
    2605                 2610                 2615                        

agt gga  gtt gac gtt ttc ttc  atc ccg cca gaa aag  tgt gac aca        7995
Ser Gly  Val Asp Val Phe Phe  Ile Pro Pro Glu Lys  Cys Asp Thr            
    2620                 2625                 2630                        

tta ttg  tgt gac ata ggg gag  tca tca cca aat ccc  aca gtg gaa        8040
Leu Leu  Cys Asp Ile Gly Glu  Ser Ser Pro Asn Pro  Thr Val Glu            
    2635                 2640                 2645                        

gca gga  cga aca ctc aga gtc  ctt aac tta gta gaa  aat tgg ttg        8085
Ala Gly  Arg Thr Leu Arg Val  Leu Asn Leu Val Glu  Asn Trp Leu            
    2650                 2655                 2660                        

aac aac  aac act caa ttt tgc  ata aag gtt ctc aac  cca tat atg        8130
Asn Asn  Asn Thr Gln Phe Cys  Ile Lys Val Leu Asn  Pro Tyr Met            
    2665                 2670                 2675                        

ccc tca  gtc ata gaa aaa atg  gaa gca cta caa agg  aaa tat gga        8175
Pro Ser  Val Ile Glu Lys Met  Glu Ala Leu Gln Arg  Lys Tyr Gly            
    2680                 2685                 2690                        

gga gcc  tta gtg agg aat cca  ctc tca cga aac tcc  aca cat gag        8220
Gly Ala  Leu Val Arg Asn Pro  Leu Ser Arg Asn Ser  Thr His Glu            
    2695                 2700                 2705                        

atg tac  tgg gta tcc aat gct  tcc ggg aac ata gtg  tca tca gtg        8265
Met Tyr  Trp Val Ser Asn Ala  Ser Gly Asn Ile Val  Ser Ser Val            
    2710                 2715                 2720                        

aac atg  att tca agg atg ttg  atc aac aga ttt aca  atg aga tac        8310
Asn Met  Ile Ser Arg Met Leu  Ile Asn Arg Phe Thr  Met Arg Tyr            
    2725                 2730                 2735                        

aag aaa  gcc act tac gag ccg  gat gtt gac ctc gga  agc gga acc        8355
Lys Lys  Ala Thr Tyr Glu Pro  Asp Val Asp Leu Gly  Ser Gly Thr            
    2740                 2745                 2750                        

cgt aac  atc ggg att gaa agt  gag ata cca aac cta  gat ata att        8400
Arg Asn  Ile Gly Ile Glu Ser  Glu Ile Pro Asn Leu  Asp Ile Ile            
    2755                 2760                 2765                        

ggg aaa  aga ata gaa aaa ata  aag caa gag cat gaa  aca tca tgg        8445
Gly Lys  Arg Ile Glu Lys Ile  Lys Gln Glu His Glu  Thr Ser Trp            
    2770                 2775                 2780                        

cac tat  gac caa gac cac cca  tac aaa acg tgg gca  tac cat ggt        8490
His Tyr  Asp Gln Asp His Pro  Tyr Lys Thr Trp Ala  Tyr His Gly            
    2785                 2790                 2795                        

agc tat  gaa aca aaa cag act  gga tca gca tca tcc  atg gtc aac        8535
Ser Tyr  Glu Thr Lys Gln Thr  Gly Ser Ala Ser Ser  Met Val Asn            
    2800                 2805                 2810                        

gga gtg  gtc agg ctg ctg aca  aaa cct tgg gac gtc  gtc ccc atg        8580
Gly Val  Val Arg Leu Leu Thr  Lys Pro Trp Asp Val  Val Pro Met            
    2815                 2820                 2825                        

gtg aca  cag atg gca atg aca  gac acg act cca ttt  gga caa cag        8625
Val Thr  Gln Met Ala Met Thr  Asp Thr Thr Pro Phe  Gly Gln Gln            
    2830                 2835                 2840                        

cgc gtt  ttt aaa gag aaa gtg  gac acg aga acc caa  gaa ccg aaa        8670
Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg Thr Gln  Glu Pro Lys            
    2845                 2850                 2855                        

gaa ggc  acg aag aaa cta atg  aaa ata aca gca gag  tgg ctt tgg        8715
Glu Gly  Thr Lys Lys Leu Met  Lys Ile Thr Ala Glu  Trp Leu Trp            
    2860                 2865                 2870                        

aaa gaa  tta ggg aag aaa aag  aca ccc agg atg tgc  acc aga gaa        8760
Lys Glu  Leu Gly Lys Lys Lys  Thr Pro Arg Met Cys  Thr Arg Glu            
    2875                 2880                 2885                        

gaa ttc  aca aga aag gtg aga  agc aat gca gcc ttg  ggg gcc ata        8805
Glu Phe  Thr Arg Lys Val Arg  Ser Asn Ala Ala Leu  Gly Ala Ile            
    2890                 2895                 2900                        

ttc act  gat gag aac aag tgg  aag tcg gca cgt gag  gct gtt gaa        8850
Phe Thr  Asp Glu Asn Lys Trp  Lys Ser Ala Arg Glu  Ala Val Glu            
    2905                 2910                 2915                        

gat agt  agg ttt tgg gag ctg  gtt gac aag gaa agg  aat ctc cat        8895
Asp Ser  Arg Phe Trp Glu Leu  Val Asp Lys Glu Arg  Asn Leu His            
    2920                 2925                 2930                        

ctt gaa  gga aag tgt gaa aca  tgt gtg tac aac atg  atg gga aaa        8940
Leu Glu  Gly Lys Cys Glu Thr  Cys Val Tyr Asn Met  Met Gly Lys            
    2935                 2940                 2945                        

aga gag  aag aag cta ggg gaa  ttc ggc aag gca aaa  ggc agc aga        8985
Arg Glu  Lys Lys Leu Gly Glu  Phe Gly Lys Ala Lys  Gly Ser Arg            
    2950                 2955                 2960                        

gcc ata  tgg tac atg tgg ctt  gga gca cgc ttc tta  gag ttt gaa        9030
Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg Phe Leu  Glu Phe Glu            
    2965                 2970                 2975                        

gcc cta  gga ttc tta aat gaa  gat cac tgg ttc tcc  aga gag aac        9075
Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp Phe Ser  Arg Glu Asn            
    2980                 2985                 2990                        

tcc ctg  agt gga gtg gaa gga  gaa ggg ctg cac aag  cta ggt tac        9120
Ser Leu  Ser Gly Val Glu Gly  Glu Gly Leu His Lys  Leu Gly Tyr            
    2995                 3000                 3005                        

att cta  aga gac gtg agc aag  aaa gag gga gga gca  atg tat gcc        9165
Ile Leu  Arg Asp Val Ser Lys  Lys Glu Gly Gly Ala  Met Tyr Ala            
    3010                 3015                 3020                        

gat gac  acc gca gga tgg gat  aca aga atc aca cta  gaa gac cta        9210
Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile Thr Leu  Glu Asp Leu            
    3025                 3030                 3035                        

aaa aat  gaa gaa atg gta aca  aac cac atg gaa gga  gaa cac aag        9255
Lys Asn  Glu Glu Met Val Thr  Asn His Met Glu Gly  Glu His Lys            
    3040                 3045                 3050                        

aaa cta  gcc gag gcc att ttc  aaa cta acg tac caa  aac aag gtg        9300
Lys Leu  Ala Glu Ala Ile Phe  Lys Leu Thr Tyr Gln  Asn Lys Val            
    3055                 3060                 3065                        

gtg cgt  gtg caa aga cca aca  cca aga ggc aca gta  atg gac atc        9345
Val Arg  Val Gln Arg Pro Thr  Pro Arg Gly Thr Val  Met Asp Ile            
    3070                 3075                 3080                        

ata tcg  aga aga gac caa aga  ggt agt gga caa gtt  ggc acc tat        9390
Ile Ser  Arg Arg Asp Gln Arg  Gly Ser Gly Gln Val  Gly Thr Tyr            
    3085                 3090                 3095                        

gga ctc  aat act ttc acc aat  atg gaa gcc caa cta  atc aga cag        9435
Gly Leu  Asn Thr Phe Thr Asn  Met Glu Ala Gln Leu  Ile Arg Gln            
    3100                 3105                 3110                        

atg gag  gga gaa gga gtc ttt  aaa agc att cag cac  cta aca atc        9480
Met Glu  Gly Glu Gly Val Phe  Lys Ser Ile Gln His  Leu Thr Ile            
    3115                 3120                 3125                        

aca gaa  gaa atc gct gtg caa  aac tgg tta gca aga  gtg ggg cgc        9525
Thr Glu  Glu Ile Ala Val Gln  Asn Trp Leu Ala Arg  Val Gly Arg            
    3130                 3135                 3140                        

gaa agg  tta tca aga atg gcc  atc agt gga gat gat  tgt gtt gtg        9570
Glu Arg  Leu Ser Arg Met Ala  Ile Ser Gly Asp Asp  Cys Val Val            
    3145                 3150                 3155                        

aaa cct  tta gat gac agg ttc  gca agc gct tta aca  gct cta aat        9615
Lys Pro  Leu Asp Asp Arg Phe  Ala Ser Ala Leu Thr  Ala Leu Asn            
    3160                 3165                 3170                        

gac atg  gga aag att agg aaa  gac ata caa caa tgg  gaa cct tca        9660
Asp Met  Gly Lys Ile Arg Lys  Asp Ile Gln Gln Trp  Glu Pro Ser            
    3175                 3180                 3185                        

aga gga  tgg aat gat tgg aca  caa gtg ccc ttc tgt  tca cac cat        9705
Arg Gly  Trp Asn Asp Trp Thr  Gln Val Pro Phe Cys  Ser His His            
    3190                 3195                 3200                        

ttc cat  gag tta atc atg aaa  gac ggt cgc gta ctc  gtt gtt cca        9750
Phe His  Glu Leu Ile Met Lys  Asp Gly Arg Val Leu  Val Val Pro            
    3205                 3210                 3215                        

tgt aga  aac caa gat gaa ctg  att ggc aga gcc cga  atc tcc caa        9795
Cys Arg  Asn Gln Asp Glu Leu  Ile Gly Arg Ala Arg  Ile Ser Gln            
    3220                 3225                 3230                        

gga gca  ggg tgg tct ttg cgg  gag acg gcc tgt ttg  ggg aag tct        9840
Gly Ala  Gly Trp Ser Leu Arg  Glu Thr Ala Cys Leu  Gly Lys Ser            
    3235                 3240                 3245                        

tac gcc  caa atg tgg agc ttg  atg tac ttc cac aga  cgc gac ctc        9885
Tyr Ala  Gln Met Trp Ser Leu  Met Tyr Phe His Arg  Arg Asp Leu            
    3250                 3255                 3260                        

agg ctg  gcg gca aat gct att  tgc tcg gca gta cca  tca cat tgg        9930
Arg Leu  Ala Ala Asn Ala Ile  Cys Ser Ala Val Pro  Ser His Trp            
    3265                 3270                 3275                        

gtt cca  aca agt cga aca acc  tgg tcc ata cat gct  aaa cat gaa        9975
Val Pro  Thr Ser Arg Thr Thr  Trp Ser Ile His Ala  Lys His Glu            
    3280                 3285                 3290                        

tgg atg  aca acg gaa gac atg  ctg aca gtc tgg aac  agg gtg tgg       10020
Trp Met  Thr Thr Glu Asp Met  Leu Thr Val Trp Asn  Arg Val Trp            
    3295                 3300                 3305                        

att caa  gaa aac cca tgg atg  gaa gac aaa act cca  gtg gaa tca       10065
Ile Gln  Glu Asn Pro Trp Met  Glu Asp Lys Thr Pro  Val Glu Ser            
    3310                 3315                 3320                        

tgg gag  gaa atc cca tac ttg  ggg aaa aga gaa gac  caa tgg tgc       10110
Trp Glu  Glu Ile Pro Tyr Leu  Gly Lys Arg Glu Asp  Gln Trp Cys            
    3325                 3330                 3335                        

ggc tca  ttg att ggg tta aca  agc agg gcc acc tgg  gca aag aac       10155
Gly Ser  Leu Ile Gly Leu Thr  Ser Arg Ala Thr Trp  Ala Lys Asn            
    3340                 3345                 3350                        

atc caa  gca gca ata aat caa  gtt aga tcc ctt ata  ggc aat gaa       10200
Ile Gln  Ala Ala Ile Asn Gln  Val Arg Ser Leu Ile  Gly Asn Glu            
    3355                 3360                 3365                        

gaa tac  aca gat tac atg cca  tcc atg aaa aga ttc  aga aga gaa       10245
Glu Tyr  Thr Asp Tyr Met Pro  Ser Met Lys Arg Phe  Arg Arg Glu            
    3370                 3375                 3380                        

gag gaa  gaa gca gga gtt ctg  tgg tag aaagcaaaac taacatgaaa          10292
Glu Glu  Glu Ala Gly Val Leu  Trp                                         
    3385                 3390                                             

caaggctaga agtcaggtcg gattaagcca tagtacggaa aaaactatgc tacctgtgag    10352

ccccgtccaa ggacgttaaa agaagtcagg ccatcataaa tgccatagct tgagtaaact    10412

atgcagcctg tagctccacc tgagaaggtg taaaaaatcc gggaggccac aaaccatgga    10472

agctgtacgc atggcgtagt ggactagcgg ttagaggaga cccctccctt acaaatcgca    10532

gcaacaatgg gggcccaagg cgagatgaag ctgtagtctc gctggaagga ctagaggtta    10592

gaggagaccc ccccgaaaca aaaaacagca tattgacgct gggaaagacc agagatcctg    10652

ctgtctcctc agcatcattc caggcacaga acgccagaaa atggaatggt gctgttgaat    10712

caacaggttc t                                                         10723


<210>  6
<211>  3391
<212>  PRT
<213>  Dengue virus type 2

<400>  6

Met Asn Asn Gln Arg Lys Lys Ala Lys Asn Thr Pro Phe Asn Met Leu 
1               5                   10                  15      


Lys Arg Glu Arg Asn Arg Val Ser Thr Val Gln Gln Leu Thr Lys Arg 
            20                  25                  30          


Phe Ser Leu Gly Met Leu Gln Gly Arg Gly Pro Leu Lys Leu Phe Met 
        35                  40                  45              


Ala Leu Val Ala Phe Leu Arg Phe Leu Thr Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Ile Leu Lys Arg Trp Gly Thr Ile Lys Lys Ser Lys Ala Ile Asn Val 
65                  70                  75                  80  


Leu Arg Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn 
                85                  90                  95      


Arg Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val 
            100                 105                 110         


Met Ala Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val 
        115                 120                 125             


Ser Arg Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp Gly 
    130                 135                 140                 


Val Asn Met Cys Thr Leu Met Ala Met Asp Leu Gly Glu Leu Cys Glu 
145                 150                 155                 160 


Asp Thr Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu 
                165                 170                 175     


Asp Ile Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly 
            180                 185                 190         


Thr Cys Thr Thr Met Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp 
    210                 215                 220                 


Met Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr Trp 
225                 230                 235                 240 


Ile Leu Arg His Pro Gly Phe Thr Met Met Ala Ala Ile Leu Ala Tyr 
                245                 250                 255     


Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu 
            260                 265                 270         


Thr Ala Val Thr Pro Ser Met Thr Met Arg Cys Ile Gly Met Ser Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile Val 
    290                 295                 300                 


Leu Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu 
                325                 330                 335     


Arg Lys Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln Asp Lys 
        355                 360                 365             


Arg Phe Val Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe Arg 
385                 390                 395                 400 


Cys Lys Lys Asn Met Glu Gly Lys Val Val Gln Pro Glu Asn Leu Glu 
                405                 410                 415     


Tyr Thr Ile Val Ile Thr Pro His Ser Gly Glu Glu His Ala Val Gly 
            420                 425                 430         


Asn Asp Thr Gly Lys His Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser 
        435                 440                 445             


Ser Ile Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu 
    450                 455                 460                 


Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln 
465                 470                 475                 480 


Met Glu Asn Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp Leu 
                485                 490                 495     


Pro Leu Pro Trp Leu Pro Gly Ala Asp Thr Gln Gly Ser Asn Trp Ile 
            500                 505                 510         


Gln Lys Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys Gln 
        515                 520                 525             


Asp Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu 
    530                 535                 540                 


Thr Gly Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr 
545                 550                 555                 560 


Gly His Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly 
                565                 570                 575     


Met Ser Tyr Ser Met Cys Thr Gly Lys Phe Lys Val Val Lys Glu Ile 
            580                 585                 590         


Ala Glu Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly 
        595                 600                 605             


Asp Gly Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys 
    610                 615                 620                 


Arg His Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu 
625                 630                 635                 640 


Lys Asp Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser 
                645                 650                 655     


Tyr Ile Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe 
            660                 665                 670         


Lys Lys Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly 
        675                 680                 685             


Ala Lys Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser 
    690                 695                 700                 


Leu Gly Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe 
705                 710                 715                 720 


Gly Ala Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met Lys 
                725                 730                 735     


Ile Leu Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg Ser 
            740                 745                 750         


Thr Ser Leu Ser Val Thr Leu Val Leu Val Gly Ile Val Thr Leu Tyr 
        755                 760                 765             


Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys 
    770                 775                 780                 


Asn Lys Glu Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val 
785                 790                 795                 800 


His Thr Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys 
                805                 810                 815     


Leu Ala Ser Ala Ile Gln Lys Ala His Glu Glu Gly Ile Cys Gly Ile 
            820                 825                 830         


Arg Ser Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro 
        835                 840                 845             


Glu Leu Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met 
    850                 855                 860                 


Thr Gly Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Arg 
865                 870                 875                 880 


Pro Gln Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala 
                885                 890                 895     


Lys Met Leu Ser Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly 
            900                 905                 910         


Pro Glu Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu 
        915                 920                 925             


Glu Val Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu 
    930                 935                 940                 


Lys Leu Lys Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser 
945                 950                 955                 960 


Ala Ala Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp 
                965                 970                 975     


Ile Glu Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe 
            980                 985                 990         


Ile Glu Val Lys Asn Cys His Trp  Pro Lys Ser His Thr  Leu Trp Ser 
        995                 1000                 1005             


Asn Gly  Val Leu Glu Ser Glu  Met Ile Ile Pro Lys  Asn Leu Ala 
    1010                 1015                 1020             


Gly Pro  Val Ser Gln His Asn  Tyr Arg Pro Gly Tyr  His Thr Gln 
    1025                 1030                 1035             


Ile Thr  Gly Pro Trp His Leu  Gly Lys Leu Glu Met  Asp Phe Asp 
    1040                 1045                 1050             


Phe Cys  Asp Gly Thr Thr Val  Val Val Thr Glu Asp  Cys Gly Asn 
    1055                 1060                 1065             


Arg Gly  Pro Ser Leu Arg Thr  Thr Thr Ala Ser Gly  Lys Leu Ile 
    1070                 1075                 1080             


Thr Glu  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr 
    1085                 1090                 1095             


Arg Gly  Glu Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Leu 
    1100                 1105                 1110             


Lys Glu  Lys Glu Glu Asn Leu  Val Asn Ser Leu Val  Thr Ala Gly 
    1115                 1120                 1125             


His Gly  Gln Val Asp Asn Phe  Ser Leu Gly Val Leu  Gly Met Ala 
    1130                 1135                 1140             


Leu Phe  Leu Glu Glu Met Leu  Arg Thr Arg Val Gly  Thr Lys His 
    1145                 1150                 1155             


Ala Ile  Leu Leu Val Ala Val  Ser Phe Val Thr Leu  Ile Thr Gly 
    1160                 1165                 1170             


Asn Met  Ser Phe Arg Asp Leu  Gly Arg Val Met Val  Met Val Gly 
    1175                 1180                 1185             


Ala Thr  Met Thr Asp Asp Ile  Gly Met Gly Val Thr  Tyr Leu Ala 
    1190                 1195                 1200             


Leu Leu  Ala Ala Phe Lys Val  Arg Pro Thr Phe Ala  Ala Gly Leu 
    1205                 1210                 1215             


Leu Leu  Arg Lys Leu Thr Ser  Lys Glu Leu Met Met  Thr Thr Ile 
    1220                 1225                 1230             


Gly Ile  Val Leu Leu Ser Gln  Ser Thr Ile Pro Glu  Thr Ile Leu 
    1235                 1240                 1245             


Glu Leu  Thr Asp Ala Leu Ala  Leu Gly Met Met Val  Leu Lys Met 
    1250                 1255                 1260             


Val Arg  Asn Met Glu Lys Tyr  Gln Leu Ala Val Thr  Ile Met Ala 
    1265                 1270                 1275             


Ile Leu  Cys Val Pro Asn Ala  Val Ile Leu Gln Asn  Ala Trp Lys 
    1280                 1285                 1290             


Val Ser  Cys Thr Ile Leu Ala  Val Val Ser Val Ser  Pro Leu Leu 
    1295                 1300                 1305             


Leu Thr  Ser Ser Gln Gln Lys  Thr Asp Trp Ile Pro  Leu Ala Leu 
    1310                 1315                 1320             


Thr Ile  Lys Gly Leu Asn Pro  Thr Ala Ile Phe Leu  Thr Thr Leu 
    1325                 1330                 1335             


Ser Arg  Thr Ser Lys Lys Arg  Ser Trp Pro Leu Asn  Glu Ala Ile 
    1340                 1345                 1350             


Met Ala  Val Gly Met Val Ser  Ile Leu Ala Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Asn Asp  Ile Pro Met Thr Gly  Pro Leu Val Ala Gly  Gly Leu Leu 
    1370                 1375                 1380             


Thr Val  Cys Tyr Val Leu Thr  Gly Arg Ser Ala Asp  Leu Glu Leu 
    1385                 1390                 1395             


Glu Arg  Ala Ala Asp Val Lys  Trp Glu Asp Gln Ala  Glu Ile Ser 
    1400                 1405                 1410             


Gly Ser  Ser Pro Ile Leu Ser  Ile Thr Ile Ser Glu  Asp Gly Ser 
    1415                 1420                 1425             


Met Ser  Ile Lys Asn Glu Glu  Glu Glu Gln Thr Leu  Thr Ile Leu 
    1430                 1435                 1440             


Ile Arg  Thr Gly Leu Leu Val  Ile Ser Gly Leu Phe  Pro Val Ser 
    1445                 1450                 1455             


Ile Pro  Ile Thr Ala Ala Ala  Trp Tyr Leu Trp Glu  Val Lys Lys 
    1460                 1465                 1470             


Gln Arg  Ala Gly Val Leu Trp  Asp Val Pro Ser Pro  Pro Pro Met 
    1475                 1480                 1485             


Gly Lys  Ala Glu Leu Glu Asp  Gly Ala Tyr Arg Ile  Lys Gln Lys 
    1490                 1495                 1500             


Gly Ile  Leu Gly Tyr Ser Gln  Ile Gly Ala Gly Val  Tyr Lys Glu 
    1505                 1510                 1515             


Gly Thr  Phe His Thr Met Trp  His Val Thr Arg Gly  Ala Val Leu 
    1520                 1525                 1530             


Met His  Lys Gly Lys Arg Ile  Glu Pro Ser Trp Ala  Asp Val Lys 
    1535                 1540                 1545             


Lys Asp  Leu Ile Ser Tyr Gly  Gly Gly Trp Lys Leu  Glu Gly Glu 
    1550                 1555                 1560             


Trp Lys  Glu Gly Glu Glu Val  Gln Val Leu Ala Leu  Glu Pro Gly 
    1565                 1570                 1575             


Lys Asn  Pro Arg Ala Val Gln  Thr Lys Pro Gly Leu  Phe Lys Thr 
    1580                 1585                 1590             


Asn Ala  Gly Thr Ile Gly Ala  Val Ser Leu Asp Phe  Ser Pro Gly 
    1595                 1600                 1605             


Thr Ser  Gly Ser Pro Ile Ile  Asp Lys Lys Gly Lys  Val Val Gly 
    1610                 1615                 1620             


Leu Tyr  Gly Asn Gly Val Val  Thr Arg Ser Gly Ala  Tyr Val Ser 
    1625                 1630                 1635             


Ala Ile  Ala Gln Thr Glu Lys  Ser Ile Glu Asp Asn  Pro Glu Ile 
    1640                 1645                 1650             


Glu Asp  Asp Ile Phe Arg Lys  Arg Arg Leu Thr Ile  Met Asp Leu 
    1655                 1660                 1665             


His Pro  Gly Ala Gly Lys Thr  Lys Arg Tyr Leu Pro  Ala Ile Val 
    1670                 1675                 1680             


Arg Glu  Ala Ile Lys Arg Gly  Leu Arg Thr Leu Ile  Leu Ala Pro 
    1685                 1690                 1695             


Thr Arg  Val Val Ala Ala Glu  Met Glu Glu Ala Leu  Arg Gly Leu 
    1700                 1705                 1710             


Pro Ile  Arg Tyr Gln Thr Pro  Ala Ile Arg Ala Glu  His Thr Gly 
    1715                 1720                 1725             


Arg Glu  Ile Val Asp Leu Met  Cys His Ala Thr Phe  Thr Met Arg 
    1730                 1735                 1740             


Leu Leu  Ser Pro Val Arg Val  Pro Asn Tyr Asn Leu  Ile Ile Met 
    1745                 1750                 1755             


Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly 
    1760                 1765                 1770             


Tyr Ile  Ser Thr Arg Val Glu  Met Gly Glu Ala Ala  Gly Ile Phe 
    1775                 1780                 1785             


Met Thr  Ala Thr Pro Pro Gly  Ser Arg Asp Pro Phe  Pro Gln Ser 
    1790                 1795                 1800             


Asn Ala  Pro Ile Ile Asp Glu  Glu Arg Glu Ile Pro  Glu Arg Ser 
    1805                 1810                 1815             


Trp Asn  Ser Gly His Glu Trp  Val Thr Asp Phe Lys  Gly Lys Thr 
    1820                 1825                 1830             


Val Trp  Phe Val Pro Ser Ile  Lys Ala Gly Asn Asp  Ile Ala Ala 
    1835                 1840                 1845             


Cys Leu  Arg Lys Asn Gly Lys  Lys Val Ile Gln Leu  Ser Arg Lys 
    1850                 1855                 1860             


Thr Phe  Asp Ser Glu Tyr Val  Lys Thr Arg Thr Asn  Asp Trp Asp 
    1865                 1870                 1875             


Phe Val  Val Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys 
    1880                 1885                 1890             


Ala Glu  Arg Val Ile Asp Pro  Arg Arg Cys Met Lys  Pro Val Ile 
    1895                 1900                 1905             


Leu Thr  Asp Gly Glu Glu Arg  Val Ile Leu Ala Gly  Pro Met Pro 
    1910                 1915                 1920             


Val Thr  His Ser Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg 
    1925                 1930                 1935             


Asn Pro  Lys Asn Glu Asn Asp  Gln Tyr Ile Tyr Met  Gly Glu Pro 
    1940                 1945                 1950             


Leu Glu  Asn Asp Glu Asp Cys  Ala His Trp Lys Glu  Ala Lys Met 
    1955                 1960                 1965             


Leu Leu  Asp Asn Ile Asn Thr  Pro Glu Gly Ile Ile  Pro Ser Met 
    1970                 1975                 1980             


Phe Glu  Pro Glu Arg Glu Lys  Val Asp Ala Ile Asp  Gly Glu Tyr 
    1985                 1990                 1995             


Arg Leu  Arg Gly Glu Ala Arg  Lys Thr Phe Val Asp  Leu Met Arg 
    2000                 2005                 2010             


Arg Gly  Asp Leu Pro Val Trp  Leu Ala Tyr Arg Val  Ala Ala Glu 
    2015                 2020                 2025             


Gly Ile  Asn Tyr Ala Asp Arg  Arg Trp Cys Phe Asp  Gly Val Lys 
    2030                 2035                 2040             


Asn Asn  Gln Ile Leu Glu Glu  Asn Val Glu Val Glu  Ile Trp Thr 
    2045                 2050                 2055             


Lys Glu  Gly Glu Arg Lys Lys  Leu Lys Pro Arg Trp  Leu Asp Ala 
    2060                 2065                 2070             


Arg Ile  Tyr Ser Asp Pro Leu  Ala Leu Lys Glu Phe  Lys Glu Phe 
    2075                 2080                 2085             


Ala Ala  Gly Arg Lys Ser Leu  Thr Leu Asn Leu Ile  Thr Glu Met 
    2090                 2095                 2100             


Gly Arg  Leu Pro Thr Phe Met  Thr Gln Lys Ala Arg  Asp Ala Leu 
    2105                 2110                 2115             


Asp Asn  Leu Ala Val Leu His  Thr Ala Glu Ala Gly  Gly Arg Ala 
    2120                 2125                 2130             


Tyr Asn  His Ala Leu Ser Glu  Leu Pro Glu Thr Leu  Glu Thr Leu 
    2135                 2140                 2145             


Leu Leu  Leu Thr Leu Leu Ala  Thr Val Thr Gly Gly  Ile Phe Leu 
    2150                 2155                 2160             


Phe Leu  Met Ser Gly Arg Gly  Ile Gly Lys Met Thr  Leu Gly Met 
    2165                 2170                 2175             


Cys Cys  Ile Ile Thr Ala Ser  Ile Leu Leu Trp Tyr  Ala Gln Ile 
    2180                 2185                 2190             


Gln Pro  His Trp Ile Ala Ala  Ser Ile Ile Leu Glu  Phe Phe Leu 
    2195                 2200                 2205             


Ile Val  Leu Leu Ile Pro Glu  Pro Glu Lys Gln Arg  Thr Pro Gln 
    2210                 2215                 2220             


Asp Asn  Gln Leu Thr Tyr Val  Val Ile Ala Ile Leu  Thr Val Val 
    2225                 2230                 2235             


Ala Ala  Thr Met Ala Asn Glu  Met Gly Phe Leu Glu  Lys Thr Lys 
    2240                 2245                 2250             


Lys Asp  Leu Gly Leu Gly Ser  Ile Ala Thr Gln Gln  Pro Glu Ser 
    2255                 2260                 2265             


Asn Ile  Leu Asp Ile Asp Leu  Arg Pro Ala Ser Ala  Trp Thr Leu 
    2270                 2275                 2280             


Tyr Ala  Val Ala Thr Thr Phe  Val Thr Pro Met Leu  Arg His Ser 
    2285                 2290                 2295             


Ile Glu  Asn Ser Ser Val Asn  Val Ser Leu Thr Ala  Ile Ala Asn 
    2300                 2305                 2310             


Gln Ala  Thr Val Leu Met Gly  Leu Gly Lys Gly Trp  Pro Leu Ser 
    2315                 2320                 2325             


Lys Met  Asp Ile Gly Val Pro  Leu Leu Ala Ile Gly  Cys Tyr Ser 
    2330                 2335                 2340             


Gln Val  Asn Pro Ile Thr Leu  Thr Ala Ala Leu Phe  Leu Leu Val 
    2345                 2350                 2355             


Ala His  Tyr Ala Ile Ile Gly  Pro Gly Leu Gln Ala  Lys Ala Thr 
    2360                 2365                 2370             


Arg Glu  Ala Gln Lys Arg Ala  Ala Ala Gly Ile Met  Lys Asn Pro 
    2375                 2380                 2385             


Thr Val  Asp Gly Ile Thr Val  Ile Asp Leu Asp Pro  Ile Pro Tyr 
    2390                 2395                 2400             


Asp Pro  Lys Phe Glu Lys Gln  Leu Gly Gln Val Met  Leu Leu Val 
    2405                 2410                 2415             


Leu Cys  Val Thr Gln Val Leu  Met Met Arg Thr Thr  Trp Ala Leu 
    2420                 2425                 2430             


Cys Glu  Ala Leu Thr Leu Ala  Thr Gly Pro Ile Ser  Thr Leu Trp 
    2435                 2440                 2445             


Glu Gly  Asn Pro Gly Arg Phe  Trp Asn Thr Thr Ile  Ala Val Ser 
    2450                 2455                 2460             


Met Ala  Asn Ile Phe Arg Gly  Ser Tyr Leu Ala Gly  Ala Gly Leu 
    2465                 2470                 2475             


Leu Phe  Ser Ile Met Lys Asn  Thr Thr Asn Thr Arg  Arg Gly Thr 
    2480                 2485                 2490             


Gly Asn  Ile Gly Glu Thr Leu  Gly Glu Lys Trp Lys  Ser Arg Leu 
    2495                 2500                 2505             


Asn Ala  Leu Gly Lys Ser Glu  Phe Gln Ile Tyr Lys  Lys Ser Gly 
    2510                 2515                 2520             


Ile Gln  Glu Val Asp Arg Thr  Leu Ala Lys Glu Gly  Ile Lys Arg 
    2525                 2530                 2535             


Gly Glu  Thr Asp His His Ala  Val Ser Arg Gly Ser  Ala Lys Leu 
    2540                 2545                 2550             


Arg Trp  Phe Val Glu Arg Asn  Met Val Thr Pro Glu  Gly Lys Val 
    2555                 2560                 2565             


Val Asp  Leu Gly Cys Gly Arg  Gly Gly Trp Ser Tyr  Tyr Cys Gly 
    2570                 2575                 2580             


Gly Leu  Lys Asn Val Arg Glu  Val Lys Gly Leu Thr  Lys Gly Gly 
    2585                 2590                 2595             


Pro Gly  His Glu Glu Pro Ile  Pro Met Ser Thr Tyr  Gly Trp Asn 
    2600                 2605                 2610             


Leu Val  Arg Leu Gln Ser Gly  Val Asp Val Phe Phe  Ile Pro Pro 
    2615                 2620                 2625             


Glu Lys  Cys Asp Thr Leu Leu  Cys Asp Ile Gly Glu  Ser Ser Pro 
    2630                 2635                 2640             


Asn Pro  Thr Val Glu Ala Gly  Arg Thr Leu Arg Val  Leu Asn Leu 
    2645                 2650                 2655             


Val Glu  Asn Trp Leu Asn Asn  Asn Thr Gln Phe Cys  Ile Lys Val 
    2660                 2665                 2670             


Leu Asn  Pro Tyr Met Pro Ser  Val Ile Glu Lys Met  Glu Ala Leu 
    2675                 2680                 2685             


Gln Arg  Lys Tyr Gly Gly Ala  Leu Val Arg Asn Pro  Leu Ser Arg 
    2690                 2695                 2700             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Asn Ala  Ser Gly Asn 
    2705                 2710                 2715             


Ile Val  Ser Ser Val Asn Met  Ile Ser Arg Met Leu  Ile Asn Arg 
    2720                 2725                 2730             


Phe Thr  Met Arg Tyr Lys Lys  Ala Thr Tyr Glu Pro  Asp Val Asp 
    2735                 2740                 2745             


Leu Gly  Ser Gly Thr Arg Asn  Ile Gly Ile Glu Ser  Glu Ile Pro 
    2750                 2755                 2760             


Asn Leu  Asp Ile Ile Gly Lys  Arg Ile Glu Lys Ile  Lys Gln Glu 
    2765                 2770                 2775             


His Glu  Thr Ser Trp His Tyr  Asp Gln Asp His Pro  Tyr Lys Thr 
    2780                 2785                 2790             


Trp Ala  Tyr His Gly Ser Tyr  Glu Thr Lys Gln Thr  Gly Ser Ala 
    2795                 2800                 2805             


Ser Ser  Met Val Asn Gly Val  Val Arg Leu Leu Thr  Lys Pro Trp 
    2810                 2815                 2820             


Asp Val  Val Pro Met Val Thr  Gln Met Ala Met Thr  Asp Thr Thr 
    2825                 2830                 2835             


Pro Phe  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2840                 2845                 2850             


Thr Gln  Glu Pro Lys Glu Gly  Thr Lys Lys Leu Met  Lys Ile Thr 
    2855                 2860                 2865             


Ala Glu  Trp Leu Trp Lys Glu  Leu Gly Lys Lys Lys  Thr Pro Arg 
    2870                 2875                 2880             


Met Cys  Thr Arg Glu Glu Phe  Thr Arg Lys Val Arg  Ser Asn Ala 
    2885                 2890                 2895             


Ala Leu  Gly Ala Ile Phe Thr  Asp Glu Asn Lys Trp  Lys Ser Ala 
    2900                 2905                 2910             


Arg Glu  Ala Val Glu Asp Ser  Arg Phe Trp Glu Leu  Val Asp Lys 
    2915                 2920                 2925             


Glu Arg  Asn Leu His Leu Glu  Gly Lys Cys Glu Thr  Cys Val Tyr 
    2930                 2935                 2940             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Leu Gly Glu  Phe Gly Lys 
    2945                 2950                 2955             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2960                 2965                 2970             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    2975                 2980                 2985             


Phe Ser  Arg Glu Asn Ser Leu  Ser Gly Val Glu Gly  Glu Gly Leu 
    2990                 2995                 3000             


His Lys  Leu Gly Tyr Ile Leu  Arg Asp Val Ser Lys  Lys Glu Gly 
    3005                 3010                 3015             


Gly Ala  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3020                 3025                 3030             


Thr Leu  Glu Asp Leu Lys Asn  Glu Glu Met Val Thr  Asn His Met 
    3035                 3040                 3045             


Glu Gly  Glu His Lys Lys Leu  Ala Glu Ala Ile Phe  Lys Leu Thr 
    3050                 3055                 3060             


Tyr Gln  Asn Lys Val Val Arg  Val Gln Arg Pro Thr  Pro Arg Gly 
    3065                 3070                 3075             


Thr Val  Met Asp Ile Ile Ser  Arg Arg Asp Gln Arg  Gly Ser Gly 
    3080                 3085                 3090             


Gln Val  Gly Thr Tyr Gly Leu  Asn Thr Phe Thr Asn  Met Glu Ala 
    3095                 3100                 3105             


Gln Leu  Ile Arg Gln Met Glu  Gly Glu Gly Val Phe  Lys Ser Ile 
    3110                 3115                 3120             


Gln His  Leu Thr Ile Thr Glu  Glu Ile Ala Val Gln  Asn Trp Leu 
    3125                 3130                 3135             


Ala Arg  Val Gly Arg Glu Arg  Leu Ser Arg Met Ala  Ile Ser Gly 
    3140                 3145                 3150             


Asp Asp  Cys Val Val Lys Pro  Leu Asp Asp Arg Phe  Ala Ser Ala 
    3155                 3160                 3165             


Leu Thr  Ala Leu Asn Asp Met  Gly Lys Ile Arg Lys  Asp Ile Gln 
    3170                 3175                 3180             


Gln Trp  Glu Pro Ser Arg Gly  Trp Asn Asp Trp Thr  Gln Val Pro 
    3185                 3190                 3195             


Phe Cys  Ser His His Phe His  Glu Leu Ile Met Lys  Asp Gly Arg 
    3200                 3205                 3210             


Val Leu  Val Val Pro Cys Arg  Asn Gln Asp Glu Leu  Ile Gly Arg 
    3215                 3220                 3225             


Ala Arg  Ile Ser Gln Gly Ala  Gly Trp Ser Leu Arg  Glu Thr Ala 
    3230                 3235                 3240             


Cys Leu  Gly Lys Ser Tyr Ala  Gln Met Trp Ser Leu  Met Tyr Phe 
    3245                 3250                 3255             


His Arg  Arg Asp Leu Arg Leu  Ala Ala Asn Ala Ile  Cys Ser Ala 
    3260                 3265                 3270             


Val Pro  Ser His Trp Val Pro  Thr Ser Arg Thr Thr  Trp Ser Ile 
    3275                 3280                 3285             


His Ala  Lys His Glu Trp Met  Thr Thr Glu Asp Met  Leu Thr Val 
    3290                 3295                 3300             


Trp Asn  Arg Val Trp Ile Gln  Glu Asn Pro Trp Met  Glu Asp Lys 
    3305                 3310                 3315             


Thr Pro  Val Glu Ser Trp Glu  Glu Ile Pro Tyr Leu  Gly Lys Arg 
    3320                 3325                 3330             


Glu Asp  Gln Trp Cys Gly Ser  Leu Ile Gly Leu Thr  Ser Arg Ala 
    3335                 3340                 3345             


Thr Trp  Ala Lys Asn Ile Gln  Ala Ala Ile Asn Gln  Val Arg Ser 
    3350                 3355                 3360             


Leu Ile  Gly Asn Glu Glu Tyr  Thr Asp Tyr Met Pro  Ser Met Lys 
    3365                 3370                 3375             


Arg Phe  Arg Arg Glu Glu Glu  Glu Ala Gly Val Leu  Trp 
    3380                 3385                 3390     


<210>  7
<211>  10699
<212>  DNA
<213>  Dengue virus type 3


<220>
<221>  CDS
<222>  (95)..(10267)

<400>  7
agttgttagt ctacgtggac cgacaagaac agtttcgact cggaagcttg cttaacgtag       60

tgctgacagt tttttattag agagcagatc tctg atg aac aac caa cgg aaa aag      115
                                      Met Asn Asn Gln Arg Lys Lys         
                                      1               5                   

acg gga aaa ccg tct atc aat atg ctg aaa cgc gtg aga aac cgt gtg        163
Thr Gly Lys Pro Ser Ile Asn Met Leu Lys Arg Val Arg Asn Arg Val           
        10                  15                  20                        

tca act gga tca cag ttg gcg aag aga ttc tca aga gga ttg ctg aac        211
Ser Thr Gly Ser Gln Leu Ala Lys Arg Phe Ser Arg Gly Leu Leu Asn           
    25                  30                  35                            

ggc caa gga cca atg aaa ttg gtt atg gca ttt ata gct ttc ctc aga        259
Gly Gln Gly Pro Met Lys Leu Val Met Ala Phe Ile Ala Phe Leu Arg           
40                  45                  50                  55            

ttt cta gcc att cca ccg aca gca gga gtc ttg gct aga tgg ggt acc        307
Phe Leu Ala Ile Pro Pro Thr Ala Gly Val Leu Ala Arg Trp Gly Thr           
                60                  65                  70                

ttt aag aag tcg ggg gct att aag gtc tta aaa ggc ttc aag aag gag        355
Phe Lys Lys Ser Gly Ala Ile Lys Val Leu Lys Gly Phe Lys Lys Glu           
            75                  80                  85                    

atc tca aac atg ctg agc att atc aac aaa cgg aaa aag aca tcg ctc        403
Ile Ser Asn Met Leu Ser Ile Ile Asn Lys Arg Lys Lys Thr Ser Leu           
        90                  95                  100                       

tgt ctc atg atg atg tta cca gca aca ctt gct ttc cac tta act tca        451
Cys Leu Met Met Met Leu Pro Ala Thr Leu Ala Phe His Leu Thr Ser           
    105                 110                 115                           

cga gat gga gag ccg cgc atg att gtg ggg aag aat gaa aga gga aaa        499
Arg Asp Gly Glu Pro Arg Met Ile Val Gly Lys Asn Glu Arg Gly Lys           
120                 125                 130                 135           

tcc cta ctt ttc aag aca gcc tct gga atc aac atg tgc aca ctc ata        547
Ser Leu Leu Phe Lys Thr Ala Ser Gly Ile Asn Met Cys Thr Leu Ile           
                140                 145                 150               

gcc atg gat ctg gga gag atg tgt gat gac acg gtc act tac aaa tgc        595
Ala Met Asp Leu Gly Glu Met Cys Asp Asp Thr Val Thr Tyr Lys Cys           
            155                 160                 165                   

ccc cac att acc gaa gtg gag cct gaa gac att gac tgc tgg tgc aac        643
Pro His Ile Thr Glu Val Glu Pro Glu Asp Ile Asp Cys Trp Cys Asn           
        170                 175                 180                       

ctt aca tcg aca tgg gtg act tat gga aca tgc aat caa gct gga gag        691
Leu Thr Ser Thr Trp Val Thr Tyr Gly Thr Cys Asn Gln Ala Gly Glu           
    185                 190                 195                           

cat aga cgc gat aag aga tca gtg gcg tta gct ccc cat gtt ggc atg        739
His Arg Arg Asp Lys Arg Ser Val Ala Leu Ala Pro His Val Gly Met           
200                 205                 210                 215           

gga ctg gac aca cgc act caa acc tgg atg tcg gct gaa gga gct tgg        787
Gly Leu Asp Thr Arg Thr Gln Thr Trp Met Ser Ala Glu Gly Ala Trp           
                220                 225                 230               

aga caa gtc gag aag gta gag aca tgg gcc ctt agg cac cca ggg ttt        835
Arg Gln Val Glu Lys Val Glu Thr Trp Ala Leu Arg His Pro Gly Phe           
            235                 240                 245                   

acc ata cta gcc cta ttt ctt gcc cat tac ata ggc act tcc ttg acc        883
Thr Ile Leu Ala Leu Phe Leu Ala His Tyr Ile Gly Thr Ser Leu Thr           
        250                 255                 260                       

cag aaa gtg gtt att ttt ata cta tta atg ctg gtt acc cca tcc atg        931
Gln Lys Val Val Ile Phe Ile Leu Leu Met Leu Val Thr Pro Ser Met           
    265                 270                 275                           

aca atg aga tgt gta gga gta gga aac aga gat ttt gtg gaa ggc cta        979
Thr Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Leu           
280                 285                 290                 295           

tcg gga gct acg tgg gtt gac gtg gtg ctc gag cac ggt ggg tgt gtg       1027
Ser Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val           
                300                 305                 310               

act acc atg gct aag aac aag ccc acg ctg gac ata gag ctt cag aag       1075
Thr Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Gln Lys           
            315                 320                 325                   

acc gag gcc acc caa ctg gcg acc cta agg aag cta tgc att gag gga       1123
Thr Glu Ala Thr Gln Leu Ala Thr Leu Arg Lys Leu Cys Ile Glu Gly           
        330                 335                 340                       

aaa att acc aac ata aca acc gac tca aga tgt ccc acc caa ggg gaa       1171
Lys Ile Thr Asn Ile Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu           
    345                 350                 355                           

gcg att tta cct gag gag cag gac cag aac tac gtg tgt aag cat aca       1219
Ala Ile Leu Pro Glu Glu Gln Asp Gln Asn Tyr Val Cys Lys His Thr           
360                 365                 370                 375           

tac gtg gac aga ggc tgg gga aac ggt tgt ggt ttg ttt ggc aag gga       1267
Tyr Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly           
                380                 385                 390               

agc ttg gtg aca tgc gcg aaa ttt caa tgt tta gaa tca ata gag gga       1315
Ser Leu Val Thr Cys Ala Lys Phe Gln Cys Leu Glu Ser Ile Glu Gly           
            395                 400                 405                   

aaa gtg gtg caa cat gag aac ctc aaa tac acc gtc atc atc aca gtg       1363
Lys Val Val Gln His Glu Asn Leu Lys Tyr Thr Val Ile Ile Thr Val           
        410                 415                 420                       

cac aca gga gac caa cac cag gtg gga aat gaa acg cag gga gtc acg       1411
His Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Gln Gly Val Thr           
    425                 430                 435                           

gct gag ata aca ccc cag gca tca acc gct gaa gcc att tta cct gaa       1459
Ala Glu Ile Thr Pro Gln Ala Ser Thr Ala Glu Ala Ile Leu Pro Glu           
440                 445                 450                 455           

tat gga acc ctc ggg cta gaa tgc tca cca cgg aca ggt ttg gat ttc       1507
Tyr Gly Thr Leu Gly Leu Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe           
                460                 465                 470               

aat gaa atg atc tca ttg aca atg aag aac aaa gca tgg atg gta cat       1555
Asn Glu Met Ile Ser Leu Thr Met Lys Asn Lys Ala Trp Met Val His           
            475                 480                 485                   

aga caa tgg ttc ttt gac tta ccc cta cca tgg aca tca gga gct aca       1603
Arg Gln Trp Phe Phe Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala Thr           
        490                 495                 500                       

gca gaa aca cca act tgg aac agg aaa gag ctt ctt gtg aca ttt aaa       1651
Ala Glu Thr Pro Thr Trp Asn Arg Lys Glu Leu Leu Val Thr Phe Lys           
    505                 510                 515                           

aat gca cat gca aaa aag caa gaa gta gtt gtt ctt gga tca caa gag       1699
Asn Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln Glu           
520                 525                 530                 535           

gga gca atg cat aca gca ctg aca gga gct aca gag atc caa acc tca       1747
Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr Ser           
                540                 545                 550               

gga ggc aca agt atc ttt gcg ggg cac tta aaa tgt aga ctc aag atg       1795
Gly Gly Thr Ser Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys Met           
            555                 560                 565                   

gac aaa ttg gaa ctc aag ggg atg agc tat gca atg tgc ttg agt agc       1843
Asp Lys Leu Glu Leu Lys Gly Met Ser Tyr Ala Met Cys Leu Ser Ser           
        570                 575                 580                       

ttt gtg ttg aag aaa gaa gtc tcc gaa acg cag cat ggg aca ata ctc       1891
Phe Val Leu Lys Lys Glu Val Ser Glu Thr Gln His Gly Thr Ile Leu           
    585                 590                 595                           

att aag gtt gag tac aaa ggg gaa gat gca ccc tgc aag att cct ttc       1939
Ile Lys Val Glu Tyr Lys Gly Glu Asp Ala Pro Cys Lys Ile Pro Phe           
600                 605                 610                 615           

tcc acg gag gat gga caa gga aaa gct cac aat ggc aga ctg atc aca       1987
Ser Thr Glu Asp Gly Gln Gly Lys Ala His Asn Gly Arg Leu Ile Thr           
                620                 625                 630               

gcc aat cca gtg gtg acc aag aag gag gag cct gtc aac att gag gct       2035
Ala Asn Pro Val Val Thr Lys Lys Glu Glu Pro Val Asn Ile Glu Ala           
            635                 640                 645                   

gaa cct cct ttt gga gaa agt aac ata gta att gga att gga gac aaa       2083
Glu Pro Pro Phe Gly Glu Ser Asn Ile Val Ile Gly Ile Gly Asp Lys           
        650                 655                 660                       

gcc ctg aaa atc aac tgg tac aag aag gga agc tcg att ggg aag atg       2131
Ala Leu Lys Ile Asn Trp Tyr Lys Lys Gly Ser Ser Ile Gly Lys Met           
    665                 670                 675                           

ttc gag gcc act gcc aga ggt gca agg cgc atg gcc atc ttg gga gac       2179
Phe Glu Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly Asp           
680                 685                 690                 695           

aca gcc tgg gac ttt gga tca gtg ggt ggt gtt ttg aat tca tta ggg       2227
Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Leu Asn Ser Leu Gly           
                700                 705                 710               

aaa atg gtc cac caa ata ttt ggg agt gct tac aca gcc cta ttt ggt       2275
Lys Met Val His Gln Ile Phe Gly Ser Ala Tyr Thr Ala Leu Phe Gly           
            715                 720                 725                   

gga gtc tcc tgg atg atg aaa att gga ata ggt gtc ctc tta acc tgg       2323
Gly Val Ser Trp Met Met Lys Ile Gly Ile Gly Val Leu Leu Thr Trp           
        730                 735                 740                       

ata ggg ttg aac tca aaa aat act tct atg tca ttt tca tgc atc gcg       2371
Ile Gly Leu Asn Ser Lys Asn Thr Ser Met Ser Phe Ser Cys Ile Ala           
    745                 750                 755                           

ata gga atc att aca ctc tat ctg gga gcc gtg gtg caa gct gac atg       2419
Ile Gly Ile Ile Thr Leu Tyr Leu Gly Ala Val Val Gln Ala Asp Met           
760                 765                 770                 775           

ggg tgt gtc ata aac tgg aaa ggc aaa gaa ctc aaa tgt gga agt gga       2467
Gly Cys Val Ile Asn Trp Lys Gly Lys Glu Leu Lys Cys Gly Ser Gly           
                780                 785                 790               

att ttc gtc act aat gag gtc cac acc tgg aca gag caa tac aaa ttt       2515
Ile Phe Val Thr Asn Glu Val His Thr Trp Thr Glu Gln Tyr Lys Phe           
            795                 800                 805                   

caa gca gac tcc ccc aag aga ctg gca aca gcc att gca ggc gct tgg       2563
Gln Ala Asp Ser Pro Lys Arg Leu Ala Thr Ala Ile Ala Gly Ala Trp           
        810                 815                 820                       

gaa aat gga gtg tgc gga att agg tca aca acc aga atg gag aac ctc       2611
Glu Asn Gly Val Cys Gly Ile Arg Ser Thr Thr Arg Met Glu Asn Leu           
    825                 830                 835                           

ttg tgg aag caa ata gcc aat gaa ctg aat tac ata tta tgg gaa aac       2659
Leu Trp Lys Gln Ile Ala Asn Glu Leu Asn Tyr Ile Leu Trp Glu Asn           
840                 845                 850                 855           

aac att aaa tta acg gta gtt gta ggc gac ata act ggg gtc tta gag       2707
Asn Ile Lys Leu Thr Val Val Val Gly Asp Ile Thr Gly Val Leu Glu           
                860                 865                 870               

caa ggg aaa aga aca cta aca cca caa ccc atg gag cta aaa tat tct       2755
Gln Gly Lys Arg Thr Leu Thr Pro Gln Pro Met Glu Leu Lys Tyr Ser           
            875                 880                 885                   

tgg aaa aca tgg gga aag gca aaa ata gtg aca gct gaa aca caa aat       2803
Trp Lys Thr Trp Gly Lys Ala Lys Ile Val Thr Ala Glu Thr Gln Asn           
        890                 895                 900                       

tcc tct ttc ata ata gat ggg cca agc aca ccg gag tgt cca agt gcc       2851
Ser Ser Phe Ile Ile Asp Gly Pro Ser Thr Pro Glu Cys Pro Ser Ala           
    905                 910                 915                           

tca aga gca tgg aat gtg tgg gag gtg gag gat tac ggg ttc gga gtt       2899
Ser Arg Ala Trp Asn Val Trp Glu Val Glu Asp Tyr Gly Phe Gly Val           
920                 925                 930                 935           

ttc aca acc aac ata tgg ctg aaa ctc cga gag gtg tac acc caa cta       2947
Phe Thr Thr Asn Ile Trp Leu Lys Leu Arg Glu Val Tyr Thr Gln Leu           
                940                 945                 950               

tgt gac cat agg cta atg tcg gca gcc gtc aag gat gag agg gct gta       2995
Cys Asp His Arg Leu Met Ser Ala Ala Val Lys Asp Glu Arg Ala Val           
            955                 960                 965                   

cat gcc gac atg ggc tat tgg ata gaa agc caa aag aat ggg agt tgg       3043
His Ala Asp Met Gly Tyr Trp Ile Glu Ser Gln Lys Asn Gly Ser Trp           
        970                 975                 980                       

aag cta gaa aaa gca tcc ttc ata gag gtg aaa acc tgc aca tgg cca       3091
Lys Leu Glu Lys Ala Ser Phe Ile Glu Val Lys Thr Cys Thr Trp Pro           
    985                 990                 995                           

aaa  tca cac act ctc tgg  agc aat ggt gtg cta  gag agt gac atg        3136
Lys  Ser His Thr Leu Trp  Ser Asn Gly Val Leu  Glu Ser Asp Met            
1000                 1005                 1010                            

att  atc cca aag agt cta  gct ggt ccc att tcg  caa cac aac cac        3181
Ile  Ile Pro Lys Ser Leu  Ala Gly Pro Ile Ser  Gln His Asn His            
1015                 1020                 1025                            

agg  ccc ggg tac cac acc  caa acg gca gga ccc  tgg cac tta gga        3226
Arg  Pro Gly Tyr His Thr  Gln Thr Ala Gly Pro  Trp His Leu Gly            
1030                 1035                 1040                            

aaa  ttg gag ctg gac ttc  aac tat tgt gaa gga  aca aca gtt gtc        3271
Lys  Leu Glu Leu Asp Phe  Asn Tyr Cys Glu Gly  Thr Thr Val Val            
1045                 1050                 1055                            

atc  tca gaa aac tgt ggg  aca aga ggc cca tca  ttg aga aca aca        3316
Ile  Ser Glu Asn Cys Gly  Thr Arg Gly Pro Ser  Leu Arg Thr Thr            
1060                 1065                 1070                            

acg  gtg tca ggg aag ttg  ata cac gaa tgg tgc  tgc cgc tcg tgc        3361
Thr  Val Ser Gly Lys Leu  Ile His Glu Trp Cys  Cys Arg Ser Cys            
1075                 1080                 1085                            

aca  ctt cct ccc cta cga  tac atg gga gaa gac  ggc tgc tgg tat        3406
Thr  Leu Pro Pro Leu Arg  Tyr Met Gly Glu Asp  Gly Cys Trp Tyr            
1090                 1095                 1100                            

ggc  atg gaa atc aga ccc  att aat gag aaa gaa  gag aat atg gta        3451
Gly  Met Glu Ile Arg Pro  Ile Asn Glu Lys Glu  Glu Asn Met Val            
1105                 1110                 1115                            

aag  tct cta gcc tca gca  ggg agt gga aag gtg  gac aac ttc aca        3496
Lys  Ser Leu Ala Ser Ala  Gly Ser Gly Lys Val  Asp Asn Phe Thr            
1120                 1125                 1130                            

atg  ggt gtc ttg tgt ttg  gca atc ctc ttt gaa  gag gtg atg aga        3541
Met  Gly Val Leu Cys Leu  Ala Ile Leu Phe Glu  Glu Val Met Arg            
1135                 1140                 1145                            

gga  aaa ttt ggg aaa aaa  cac atg att gca ggg  gtt ctc ttc acg        3586
Gly  Lys Phe Gly Lys Lys  His Met Ile Ala Gly  Val Leu Phe Thr            
1150                 1155                 1160                            

ttt  gtg ctc ctc ctc tca  ggg caa ata aca tgg  aga gac atg gcg        3631
Phe  Val Leu Leu Leu Ser  Gly Gln Ile Thr Trp  Arg Asp Met Ala            
1165                 1170                 1175                            

cac  aca ctc ata atg att  ggg tcc aac gcc tct  gac aga atg ggg        3676
His  Thr Leu Ile Met Ile  Gly Ser Asn Ala Ser  Asp Arg Met Gly            
1180                 1185                 1190                            

atg  ggc gtc act tac cta  gct cta att gca aca  ttt aaa att cag        3721
Met  Gly Val Thr Tyr Leu  Ala Leu Ile Ala Thr  Phe Lys Ile Gln            
1195                 1200                 1205                            

cca  ttc ctg gct ttg gga  ttc ttc ctg agg aaa  ctg aca tct aga        3766
Pro  Phe Leu Ala Leu Gly  Phe Phe Leu Arg Lys  Leu Thr Ser Arg            
1210                 1215                 1220                            

gaa  aat tta ttg ctg gga  gtt ggg ttg gcc atg  gca gca acg tta        3811
Glu  Asn Leu Leu Leu Gly  Val Gly Leu Ala Met  Ala Ala Thr Leu            
1225                 1230                 1235                            

cga  ctg cca gag gac att  gaa cag atg gcg aat  gga att gct ttg        3856
Arg  Leu Pro Glu Asp Ile  Glu Gln Met Ala Asn  Gly Ile Ala Leu            
1240                 1245                 1250                            

ggg  ctc atg gct ctt aaa  ctg ata aca caa ttt  gaa aca tac caa        3901
Gly  Leu Met Ala Leu Lys  Leu Ile Thr Gln Phe  Glu Thr Tyr Gln            
1255                 1260                 1265                            

cta  tgg acg gca tta gtt  tcc cta acg tgt tca  aat aca att ttc        3946
Leu  Trp Thr Ala Leu Val  Ser Leu Thr Cys Ser  Asn Thr Ile Phe            
1270                 1275                 1280                            

acg  ttg act gtt gcc tgg  aga aca gcc act ctg  att tta gcc gga        3991
Thr  Leu Thr Val Ala Trp  Arg Thr Ala Thr Leu  Ile Leu Ala Gly            
1285                 1290                 1295                            

att  tcg ctt ttg cca gtg  tgc cag tct tcg agc  atg agg aaa aca        4036
Ile  Ser Leu Leu Pro Val  Cys Gln Ser Ser Ser  Met Arg Lys Thr            
1300                 1305                 1310                            

gat  tgg ctc cca atg act  gtg gca gct atg gga  gct caa ccc cta        4081
Asp  Trp Leu Pro Met Thr  Val Ala Ala Met Gly  Ala Gln Pro Leu            
1315                 1320                 1325                            

cca  ctt ttt att ttc agt  ctg aaa gat aca ctc  aaa agg aga agc        4126
Pro  Leu Phe Ile Phe Ser  Leu Lys Asp Thr Leu  Lys Arg Arg Ser            
1330                 1335                 1340                            

tgg  cca ctg aat gag ggg  gtg atg gca gtt gga  ctt gtg agc att        4171
Trp  Pro Leu Asn Glu Gly  Val Met Ala Val Gly  Leu Val Ser Ile            
1345                 1350                 1355                            

cta  gct agt tct ctc ctt  agg aat gat gtg cct  atg gct gga cca        4216
Leu  Ala Ser Ser Leu Leu  Arg Asn Asp Val Pro  Met Ala Gly Pro            
1360                 1365                 1370                            

tta  gtg gct ggg ggc ttg  ctg ata gcg tgc tac  gtc ata act ggc        4261
Leu  Val Ala Gly Gly Leu  Leu Ile Ala Cys Tyr  Val Ile Thr Gly            
1375                 1380                 1385                            

acg  tca gca gac ctc act  gta gaa aaa gca gca  gat gta aca tgg        4306
Thr  Ser Ala Asp Leu Thr  Val Glu Lys Ala Ala  Asp Val Thr Trp            
1390                 1395                 1400                            

gag  gaa gag gcc gag caa  aca gga gtg tcc cac  aat tta atg gtc        4351
Glu  Glu Glu Ala Glu Gln  Thr Gly Val Ser His  Asn Leu Met Val            
1405                 1410                 1415                            

aca  gtt gat gat gat gga  aca atg aga ata aaa  gat gac gag act        4396
Thr  Val Asp Asp Asp Gly  Thr Met Arg Ile Lys  Asp Asp Glu Thr            
1420                 1425                 1430                            

gag  aac atc tta aca gtg  ctt tta aaa aca gca  cta cta ata gta        4441
Glu  Asn Ile Leu Thr Val  Leu Leu Lys Thr Ala  Leu Leu Ile Val            
1435                 1440                 1445                            

tca  ggc atc ttt cca tac  tcc ata ccc gca aca  ctg ttg gtc tgg        4486
Ser  Gly Ile Phe Pro Tyr  Ser Ile Pro Ala Thr  Leu Leu Val Trp            
1450                 1455                 1460                            

cat  act tgg caa aag caa  acc caa aga tcc ggc  gtc cta tgg gac        4531
His  Thr Trp Gln Lys Gln  Thr Gln Arg Ser Gly  Val Leu Trp Asp            
1465                 1470                 1475                            

gta  ccc agc ccc cca gag  aca cag aaa gcg gaa  ctg gaa gaa ggg        4576
Val  Pro Ser Pro Pro Glu  Thr Gln Lys Ala Glu  Leu Glu Glu Gly            
1480                 1485                 1490                            

gtc  tat agg atc aaa cag  caa gga att ttt ggg  aaa acc caa gtg        4621
Val  Tyr Arg Ile Lys Gln  Gln Gly Ile Phe Gly  Lys Thr Gln Val            
1495                 1500                 1505                            

ggg  gtt gga gta cag aaa  gaa gga gtt ttc cac  acc atg tgg cat        4666
Gly  Val Gly Val Gln Lys  Glu Gly Val Phe His  Thr Met Trp His            
1510                 1515                 1520                            

gtc  aca aga ggg gca gtg  ttg aca cac aat ggg  aaa aga ctg gaa        4711
Val  Thr Arg Gly Ala Val  Leu Thr His Asn Gly  Lys Arg Leu Glu            
1525                 1530                 1535                            

cca  aac tgg gct agc gtg  aaa aaa gat ctg att  tca tac gga gga        4756
Pro  Asn Trp Ala Ser Val  Lys Lys Asp Leu Ile  Ser Tyr Gly Gly            
1540                 1545                 1550                            

gga  tgg aga ttg agt gca  caa tgg caa aag ggg  gag gag gtg cag        4801
Gly  Trp Arg Leu Ser Ala  Gln Trp Gln Lys Gly  Glu Glu Val Gln            
1555                 1560                 1565                            

gtt  att gcc gta gag cct  ggg aag aac cca aag  aac ttt caa acc        4846
Val  Ile Ala Val Glu Pro  Gly Lys Asn Pro Lys  Asn Phe Gln Thr            
1570                 1575                 1580                            

atg  cca ggc att ttt cag  aca aca aca ggg gaa  ata gga gca att        4891
Met  Pro Gly Ile Phe Gln  Thr Thr Thr Gly Glu  Ile Gly Ala Ile            
1585                 1590                 1595                            

gca  ctg gat ttc aag cct  gga act tca gga tct  ccc atc ata aac        4936
Ala  Leu Asp Phe Lys Pro  Gly Thr Ser Gly Ser  Pro Ile Ile Asn            
1600                 1605                 1610                            

aga  gag gga aag gta gtg  gga ctg tat ggc aat  gga gtg gtt aca        4981
Arg  Glu Gly Lys Val Val  Gly Leu Tyr Gly Asn  Gly Val Val Thr            
1615                 1620                 1625                            

aag  aat gga ggc tat gtc  agt gga ata gcg caa  aca aat gca gaa        5026
Lys  Asn Gly Gly Tyr Val  Ser Gly Ile Ala Gln  Thr Asn Ala Glu            
1630                 1635                 1640                            

cca  gat gga ccg aca cca  gag ttg gaa gaa gag  atg ttc aaa aag        5071
Pro  Asp Gly Pro Thr Pro  Glu Leu Glu Glu Glu  Met Phe Lys Lys            
1645                 1650                 1655                            

cga  aat cta acc ata atg  gat ctc cat cct ggg  tca gga aag acg        5116
Arg  Asn Leu Thr Ile Met  Asp Leu His Pro Gly  Ser Gly Lys Thr            
1660                 1665                 1670                            

cgg  aaa tat ctt cca gct  att gtt aga gag gca  atc aag aga cgc        5161
Arg  Lys Tyr Leu Pro Ala  Ile Val Arg Glu Ala  Ile Lys Arg Arg            
1675                 1680                 1685                            

tta  agg act cta att ttg  gca cca aca agg gta  gtt gca gct gag        5206
Leu  Arg Thr Leu Ile Leu  Ala Pro Thr Arg Val  Val Ala Ala Glu            
1690                 1695                 1700                            

atg  gaa gaa gca ttg aaa  ggg ctc cca ata agg  tat caa aca act        5251
Met  Glu Glu Ala Leu Lys  Gly Leu Pro Ile Arg  Tyr Gln Thr Thr            
1705                 1710                 1715                            

gca  aca aaa tct gaa cac  aca gga aga gag att  gtt gat cta atg        5296
Ala  Thr Lys Ser Glu His  Thr Gly Arg Glu Ile  Val Asp Leu Met            
1720                 1725                 1730                            

tgt  cac gca acg ttc aca  atg cgc ttg ctg tca  cca gtc agg gtt        5341
Cys  His Ala Thr Phe Thr  Met Arg Leu Leu Ser  Pro Val Arg Val            
1735                 1740                 1745                            

cca  aac tac aac ttg ata  ata atg gat gag gcc  cat ttc aca gac        5386
Pro  Asn Tyr Asn Leu Ile  Ile Met Asp Glu Ala  His Phe Thr Asp            
1750                 1755                 1760                            

cca  gcc agt ata gcg gct  aga ggg tac ata tca  act cgt gta gga        5431
Pro  Ala Ser Ile Ala Ala  Arg Gly Tyr Ile Ser  Thr Arg Val Gly            
1765                 1770                 1775                            

atg  gga gag gca gcc gca  att ttc atg aca gca  aca ccc cct gga        5476
Met  Gly Glu Ala Ala Ala  Ile Phe Met Thr Ala  Thr Pro Pro Gly            
1780                 1785                 1790                            

aca  gct gat gcc ttt cct  cag agc aac gct cca  att caa gat gaa        5521
Thr  Ala Asp Ala Phe Pro  Gln Ser Asn Ala Pro  Ile Gln Asp Glu            
1795                 1800                 1805                            

gag  aga gac ata ccg gaa  cgc tca tgg aat tca  ggc aat gaa tgg        5566
Glu  Arg Asp Ile Pro Glu  Arg Ser Trp Asn Ser  Gly Asn Glu Trp            
1810                 1815                 1820                            

att  act gac ttt gtt ggg  aag aca gtg tgg ttt  gtc cct agc atc        5611
Ile  Thr Asp Phe Val Gly  Lys Thr Val Trp Phe  Val Pro Ser Ile            
1825                 1830                 1835                            

aaa  gcc gga aat gac ata  gca aac tgc ttg cgg  aaa aat gga aaa        5656
Lys  Ala Gly Asn Asp Ile  Ala Asn Cys Leu Arg  Lys Asn Gly Lys            
1840                 1845                 1850                            

aag  gtt att caa ctc agc  agg aag acc ttt gac  aca gaa tat caa        5701
Lys  Val Ile Gln Leu Ser  Arg Lys Thr Phe Asp  Thr Glu Tyr Gln            
1855                 1860                 1865                            

aag  acc aaa ctg aat gat  tgg gac ttt gtg gtg  aca aca gac att        5746
Lys  Thr Lys Leu Asn Asp  Trp Asp Phe Val Val  Thr Thr Asp Ile            
1870                 1875                 1880                            

tca  gaa atg gga gcc aat  ttc aaa gca gat aga  gtg atc gac cca        5791
Ser  Glu Met Gly Ala Asn  Phe Lys Ala Asp Arg  Val Ile Asp Pro            
1885                 1890                 1895                            

aga  aga tgt ctc aag ccg  gtg att ttg aca gat  gga ccc gag cgg        5836
Arg  Arg Cys Leu Lys Pro  Val Ile Leu Thr Asp  Gly Pro Glu Arg            
1900                 1905                 1910                            

gtg  atc ctg gct gga cca  atg cca gtc acc gta  gcg agc gct gcg        5881
Val  Ile Leu Ala Gly Pro  Met Pro Val Thr Val  Ala Ser Ala Ala            
1915                 1920                 1925                            

caa  agg aga ggg aga gtt  ggc agg aac cca caa  aaa gaa aat gac        5926
Gln  Arg Arg Gly Arg Val  Gly Arg Asn Pro Gln  Lys Glu Asn Asp            
1930                 1935                 1940                            

cag  tac ata ttc atg ggc  cag cct ctc aac aat  gat gaa gac cat        5971
Gln  Tyr Ile Phe Met Gly  Gln Pro Leu Asn Asn  Asp Glu Asp His            
1945                 1950                 1955                            

gct  cac tgg aca gaa gca  aaa atg ctg ctg gac  aac atc aac aca        6016
Ala  His Trp Thr Glu Ala  Lys Met Leu Leu Asp  Asn Ile Asn Thr            
1960                 1965                 1970                            

cca  gaa ggg att ata cca  gct ctc ttt gaa cca  gaa agg gag aag        6061
Pro  Glu Gly Ile Ile Pro  Ala Leu Phe Glu Pro  Glu Arg Glu Lys            
1975                 1980                 1985                            

tca  gcc gcc ata gac ggc  gaa tac cgc ctg aag  ggt gag tcc agg        6106
Ser  Ala Ala Ile Asp Gly  Glu Tyr Arg Leu Lys  Gly Glu Ser Arg            
1990                 1995                 2000                            

aag  act ttc gtg gaa ctc  atg agg agg ggt gac  ctc cca gtt tgg        6151
Lys  Thr Phe Val Glu Leu  Met Arg Arg Gly Asp  Leu Pro Val Trp            
2005                 2010                 2015                            

cta  gcc cat aaa gta gca  tca gaa ggg atc aaa  tat aca gat aga        6196
Leu  Ala His Lys Val Ala  Ser Glu Gly Ile Lys  Tyr Thr Asp Arg            
2020                 2025                 2030                            

aaa  tgg tgc ttt gat gga  gaa cgt aat aat caa  att tta gag gag        6241
Lys  Trp Cys Phe Asp Gly  Glu Arg Asn Asn Gln  Ile Leu Glu Glu            
2035                 2040                 2045                            

aat  atg gat gtg gaa atc  tgg aca aag gaa gga  gaa aag aaa aaa        6286
Asn  Met Asp Val Glu Ile  Trp Thr Lys Glu Gly  Glu Lys Lys Lys            
2050                 2055                 2060                            

ctg  aga cct agg tgg ctt  gat gcc cgc act tat  tca gat cct tta        6331
Leu  Arg Pro Arg Trp Leu  Asp Ala Arg Thr Tyr  Ser Asp Pro Leu            
2065                 2070                 2075                            

gca  ctc aaa gaa ttc aag  gat ttt gca gct ggc  aga aag tca atc        6376
Ala  Leu Lys Glu Phe Lys  Asp Phe Ala Ala Gly  Arg Lys Ser Ile            
2080                 2085                 2090                            

gcc  ctt gat ctt gtg aca  gaa ata gga aga gtg  cct tca cac tta        6421
Ala  Leu Asp Leu Val Thr  Glu Ile Gly Arg Val  Pro Ser His Leu            
2095                 2100                 2105                            

gcc  cac aga acg aga aac  gcc ctg gat aat ttg  gtg atg ctg cac        6466
Ala  His Arg Thr Arg Asn  Ala Leu Asp Asn Leu  Val Met Leu His            
2110                 2115                 2120                            

acg  tca gaa cat ggc ggt  agg gcc tac agg cat  gca gtg gag gaa        6511
Thr  Ser Glu His Gly Gly  Arg Ala Tyr Arg His  Ala Val Glu Glu            
2125                 2130                 2135                            

cta  cca gaa acg atg gaa  aca ctc tta ctc ctg  gga ctg atg atc        6556
Leu  Pro Glu Thr Met Glu  Thr Leu Leu Leu Leu  Gly Leu Met Ile            
2140                 2145                 2150                            

ttg  tta aca ggt gga gca  atg ctc ttc ttg ata  tca ggt aaa ggg        6601
Leu  Leu Thr Gly Gly Ala  Met Leu Phe Leu Ile  Ser Gly Lys Gly            
2155                 2160                 2165                            

att  gga aag act tca ata  gga ctc att tgt gta  att gct tcc agc        6646
Ile  Gly Lys Thr Ser Ile  Gly Leu Ile Cys Val  Ile Ala Ser Ser            
2170                 2175                 2180                            

ggc  atg tta tgg atg gct  gat gtc cca ctc caa  tgg atc gca tcg        6691
Gly  Met Leu Trp Met Ala  Asp Val Pro Leu Gln  Trp Ile Ala Ser            
2185                 2190                 2195                            

gct  ata gtc ctg gag ttt  ttt atg atg gtg ttg  ctc ata cca gaa        6736
Ala  Ile Val Leu Glu Phe  Phe Met Met Val Leu  Leu Ile Pro Glu            
2200                 2205                 2210                            

cca  gaa aag cag aga act  ccc caa gac aac caa  ctc gca tat gtc        6781
Pro  Glu Lys Gln Arg Thr  Pro Gln Asp Asn Gln  Leu Ala Tyr Val            
2215                 2220                 2225                            

gtg  ata ggc ata ctt aca  ttg gct gca ata gta  gcg gcc aat gaa        6826
Val  Ile Gly Ile Leu Thr  Leu Ala Ala Ile Val  Ala Ala Asn Glu            
2230                 2235                 2240                            

atg  gga ctg ttg gaa act  aca aag aga gat tta  gga atg tct aaa        6871
Met  Gly Leu Leu Glu Thr  Thr Lys Arg Asp Leu  Gly Met Ser Lys            
2245                 2250                 2255                            

gaa  cca ggt gtt gtt tct  cca acc agc tat ttg  gat gtg gac ttg        6916
Glu  Pro Gly Val Val Ser  Pro Thr Ser Tyr Leu  Asp Val Asp Leu            
2260                 2265                 2270                            

cac  cca gca tca gcc tgg  aca ttg tac gcc gtg  gcc aca aca gta        6961
His  Pro Ala Ser Ala Trp  Thr Leu Tyr Ala Val  Ala Thr Thr Val            
2275                 2280                 2285                            

ata  aca cca atg ttg aga  cac acc ata gag aat  tcc aca gca aat        7006
Ile  Thr Pro Met Leu Arg  His Thr Ile Glu Asn  Ser Thr Ala Asn            
2290                 2295                 2300                            

gtg  tct ctg gca gcc ata  gct aac cag gca gtg  gtc ctg atg ggt        7051
Val  Ser Leu Ala Ala Ile  Ala Asn Gln Ala Val  Val Leu Met Gly            
2305                 2310                 2315                            

tta  gac aaa gga tgg ccg  ata tcg aaa atg gac  ttg ggc gta cca        7096
Leu  Asp Lys Gly Trp Pro  Ile Ser Lys Met Asp  Leu Gly Val Pro            
2320                 2325                 2330                            

cta  ttg gca ctg ggt tgc  tat tca caa gtg aac  cca cta act ctt        7141
Leu  Leu Ala Leu Gly Cys  Tyr Ser Gln Val Asn  Pro Leu Thr Leu            
2335                 2340                 2345                            

gca  gcg gca gta ctt ttg  cta gtc aca cat tat  gca att ata ggt        7186
Ala  Ala Ala Val Leu Leu  Leu Val Thr His Tyr  Ala Ile Ile Gly            
2350                 2355                 2360                            

cca  gga ttg cag gca aaa  gcc acc cgt gaa gct  cag aaa agg aca        7231
Pro  Gly Leu Gln Ala Lys  Ala Thr Arg Glu Ala  Gln Lys Arg Thr            
2365                 2370                 2375                            

gct  gct gga ata atg aag  aat cca acg gtg gat  gga ata atg aca        7276
Ala  Ala Gly Ile Met Lys  Asn Pro Thr Val Asp  Gly Ile Met Thr            
2380                 2385                 2390                            

ata  gac cta gat cct gta  ata tat gat tca aaa  ttt gaa aag caa        7321
Ile  Asp Leu Asp Pro Val  Ile Tyr Asp Ser Lys  Phe Glu Lys Gln            
2395                 2400                 2405                            

cta  gga cag gtc atg ctc  ctg gtt ctg tgt gca  gtc caa ctt tta        7366
Leu  Gly Gln Val Met Leu  Leu Val Leu Cys Ala  Val Gln Leu Leu            
2410                 2415                 2420                            

ttg  atg aga aca tca tgg  gcc ttg tgt gaa gtt  cta acc cta gcc        7411
Leu  Met Arg Thr Ser Trp  Ala Leu Cys Glu Val  Leu Thr Leu Ala            
2425                 2430                 2435                            

aca  gga cca ata aca aca  ctc tgg gaa gga tca  cct ggg aag ttc        7456
Thr  Gly Pro Ile Thr Thr  Leu Trp Glu Gly Ser  Pro Gly Lys Phe            
2440                 2445                 2450                            

tgg  aac acc acg ata gct  gtt tcc atg gcg aac  atc ttt aga ggg        7501
Trp  Asn Thr Thr Ile Ala  Val Ser Met Ala Asn  Ile Phe Arg Gly            
2455                 2460                 2465                            

agc  tat tta gca gga gct  ggg ctt gct ttt tct  atc atg aaa tca        7546
Ser  Tyr Leu Ala Gly Ala  Gly Leu Ala Phe Ser  Ile Met Lys Ser            
2470                 2475                 2480                            

gtt  gga aca gga aag aga  gga aca ggg tca caa  ggt gaa acc tta        7591
Val  Gly Thr Gly Lys Arg  Gly Thr Gly Ser Gln  Gly Glu Thr Leu            
2485                 2490                 2495                            

gga  gaa aag tgg aaa aag  aaa tta aat cag tta  tcc cgg aaa gag        7636
Gly  Glu Lys Trp Lys Lys  Lys Leu Asn Gln Leu  Ser Arg Lys Glu            
2500                 2505                 2510                            

ttt  gac ctt tac aag aaa  tcc gga atc acc gaa  gtg gat aga aca        7681
Phe  Asp Leu Tyr Lys Lys  Ser Gly Ile Thr Glu  Val Asp Arg Thr            
2515                 2520                 2525                            

gaa  gcc aaa gaa ggg tta  aaa aga gga gaa ata  aca cac cat gcc        7726
Glu  Ala Lys Glu Gly Leu  Lys Arg Gly Glu Ile  Thr His His Ala            
2530                 2535                 2540                            

gtg  tcc aga ggc agc gca  aaa ctt caa tgg ttc  gtg gag aga aac        7771
Val  Ser Arg Gly Ser Ala  Lys Leu Gln Trp Phe  Val Glu Arg Asn            
2545                 2550                 2555                            

atg  gtc att cct gaa gga  aga gtc ata gac cta  ggc tgt gga aga        7816
Met  Val Ile Pro Glu Gly  Arg Val Ile Asp Leu  Gly Cys Gly Arg            
2560                 2565                 2570                            

gga  ggc tgg tca tat tac  tgt gca gga ctg aaa  aaa gtt aca gaa        7861
Gly  Gly Trp Ser Tyr Tyr  Cys Ala Gly Leu Lys  Lys Val Thr Glu            
2575                 2580                 2585                            

gtg  cga gga tac aca aaa  ggc ggc cca gga cac  gaa gaa cca gta        7906
Val  Arg Gly Tyr Thr Lys  Gly Gly Pro Gly His  Glu Glu Pro Val            
2590                 2595                 2600                            

cct  atg tct aca tac gga  tgg aac ata gtc aag  tta atg agt gga        7951
Pro  Met Ser Thr Tyr Gly  Trp Asn Ile Val Lys  Leu Met Ser Gly            
2605                 2610                 2615                            

aag  gat gtt ttt tat ctg  cca cct gaa aag tgt  gat acc cta ttg        7996
Lys  Asp Val Phe Tyr Leu  Pro Pro Glu Lys Cys  Asp Thr Leu Leu            
2620                 2625                 2630                            

tgt  gac att gga gaa tct  tca cca agc cca aca  gtg gaa gaa agc        8041
Cys  Asp Ile Gly Glu Ser  Ser Pro Ser Pro Thr  Val Glu Glu Ser            
2635                 2640                 2645                            

aga  acc ata aga gtt ttg  aag atg gtt gaa cca  tgg cta aag aac        8086
Arg  Thr Ile Arg Val Leu  Lys Met Val Glu Pro  Trp Leu Lys Asn            
2650                 2655                 2660                            

aac  cag ttt tgc att aaa  gta ttg aac cca tac  atg cca act gtg        8131
Asn  Gln Phe Cys Ile Lys  Val Leu Asn Pro Tyr  Met Pro Thr Val            
2665                 2670                 2675                            

att  gag cac tta gaa aga  cta caa agg aaa cat  gga gga atg ctt        8176
Ile  Glu His Leu Glu Arg  Leu Gln Arg Lys His  Gly Gly Met Leu            
2680                 2685                 2690                            

gtg  aga aat cca ctc tca  cga aac tcc acg cac  gaa atg tat tgg        8221
Val  Arg Asn Pro Leu Ser  Arg Asn Ser Thr His  Glu Met Tyr Trp            
2695                 2700                 2705                            

ata  tcc aat ggt aca ggc  aat atc gtc tct tca  gtc aac atg gta        8266
Ile  Ser Asn Gly Thr Gly  Asn Ile Val Ser Ser  Val Asn Met Val            
2710                 2715                 2720                            

tcc  aga ttg cta ctg aac  aga ttc aca atg aca  cac agg aga ccc        8311
Ser  Arg Leu Leu Leu Asn  Arg Phe Thr Met Thr  His Arg Arg Pro            
2725                 2730                 2735                            

acc  ata gag aaa gat gtg  gat cta gga gca gga  acc cga cat gtc        8356
Thr  Ile Glu Lys Asp Val  Asp Leu Gly Ala Gly  Thr Arg His Val            
2740                 2745                 2750                            

aat  gcg gaa cca gaa aca  ccc aac atg gat gtc  att ggg gaa aga        8401
Asn  Ala Glu Pro Glu Thr  Pro Asn Met Asp Val  Ile Gly Glu Arg            
2755                 2760                 2765                            

ata  aaa agg atc aaa gag  gag cat agt tca aca  tgg cac tat gat        8446
Ile  Lys Arg Ile Lys Glu  Glu His Ser Ser Thr  Trp His Tyr Asp            
2770                 2775                 2780                            

gat  gaa aat cct tac aaa  acg tgg gct tac cat  gga tcc tat gaa        8491
Asp  Glu Asn Pro Tyr Lys  Thr Trp Ala Tyr His  Gly Ser Tyr Glu            
2785                 2790                 2795                            

gta  aaa gcc aca ggc tca  gcc tcc tcc atg ata  aat gga gtc gtg        8536
Val  Lys Ala Thr Gly Ser  Ala Ser Ser Met Ile  Asn Gly Val Val            
2800                 2805                 2810                            

aaa  ctc ctc aca aaa cca  tgg gat gtg gtg ccc  atg gtg aca cag        8581
Lys  Leu Leu Thr Lys Pro  Trp Asp Val Val Pro  Met Val Thr Gln            
2815                 2820                 2825                            

atg  gca atg aca gat aca  act cca ttc ggc cag  caa aga gtt ttt        8626
Met  Ala Met Thr Asp Thr  Thr Pro Phe Gly Gln  Gln Arg Val Phe            
2830                 2835                 2840                            

aaa  gag aaa gtg gac acc  agg aca cct agg ccc  atg cca gga aca        8671
Lys  Glu Lys Val Asp Thr  Arg Thr Pro Arg Pro  Met Pro Gly Thr            
2845                 2850                 2855                            

aga  aag gtt atg gag atc  aca gcg gag tgg ctt  tgg agg acc ctg        8716
Arg  Lys Val Met Glu Ile  Thr Ala Glu Trp Leu  Trp Arg Thr Leu            
2860                 2865                 2870                            

gga  agg aac aaa aga ccc  aga tta tgc aca agg  gag gaa ttc aca        8761
Gly  Arg Asn Lys Arg Pro  Arg Leu Cys Thr Arg  Glu Glu Phe Thr            
2875                 2880                 2885                            

aag  aag gtc aga acc aac  gca gct atg ggc gct  gtc ttc aca gaa        8806
Lys  Lys Val Arg Thr Asn  Ala Ala Met Gly Ala  Val Phe Thr Glu            
2890                 2895                 2900                            

gag  aac caa tgg gac agt  gcg aga gct gct gtt  gag gac gaa gaa        8851
Glu  Asn Gln Trp Asp Ser  Ala Arg Ala Ala Val  Glu Asp Glu Glu            
2905                 2910                 2915                            

ttt  tgg aaa ctt gtg gac  aga gaa cgt gaa ctc  cac aaa ctg ggc        8896
Phe  Trp Lys Leu Val Asp  Arg Glu Arg Glu Leu  His Lys Leu Gly            
2920                 2925                 2930                            

aag  tgt gga agc tgc gtt  tac aac atg atg ggc  aag aga gag aaa        8941
Lys  Cys Gly Ser Cys Val  Tyr Asn Met Met Gly  Lys Arg Glu Lys            
2935                 2940                 2945                            

aaa  ctt gga gag ttt ggt  aaa gca aaa ggc agt  agg gct ata tgg        8986
Lys  Leu Gly Glu Phe Gly  Lys Ala Lys Gly Ser  Arg Ala Ile Trp            
2950                 2955                 2960                            

tac  atg tgg ttg gga gcc  agg tac ctt gag ttc  gag gcg ctc gga        9031
Tyr  Met Trp Leu Gly Ala  Arg Tyr Leu Glu Phe  Glu Ala Leu Gly            
2965                 2970                 2975                            

ttc  ctc aat gaa gac cac  tgg ttc tcg cgt gaa  aac tct tac agt        9076
Phe  Leu Asn Glu Asp His  Trp Phe Ser Arg Glu  Asn Ser Tyr Ser            
2980                 2985                 2990                            

gga  gta gaa gga gaa gga  ctg cac aag ctg gga  tac atc ttg aga        9121
Gly  Val Glu Gly Glu Gly  Leu His Lys Leu Gly  Tyr Ile Leu Arg            
2995                 3000                 3005                            

gat  att tcc aag ata ccc  gga gga gcc atg tat  gct gat gac aca        9166
Asp  Ile Ser Lys Ile Pro  Gly Gly Ala Met Tyr  Ala Asp Asp Thr            
3010                 3015                 3020                            

gcc  ggt tgg gac aca aga  ata aca gaa gat gac  ctg cac aat gag        9211
Ala  Gly Trp Asp Thr Arg  Ile Thr Glu Asp Asp  Leu His Asn Glu            
3025                 3030                 3035                            

gaa  aaa atc aca cag cag  atg gac cct gaa cac  agg cag cta gcg        9256
Glu  Lys Ile Thr Gln Gln  Met Asp Pro Glu His  Arg Gln Leu Ala            
3040                 3045                 3050                            

aac  gct ata ttc aag ctc  aca tac caa aac aaa  gtg gtc aaa gtc        9301
Asn  Ala Ile Phe Lys Leu  Thr Tyr Gln Asn Lys  Val Val Lys Val            
3055                 3060                 3065                            

caa  cga cca act cca aag  ggc acg gta atg gac  atc ata tct agg        9346
Gln  Arg Pro Thr Pro Lys  Gly Thr Val Met Asp  Ile Ile Ser Arg            
3070                 3075                 3080                            

aaa  gac caa aga ggc agt  gga cag gtg gga act  tat ggt ctg aac        9391
Lys  Asp Gln Arg Gly Ser  Gly Gln Val Gly Thr  Tyr Gly Leu Asn            
3085                 3090                 3095                            

aca  ttc acc aac atg gaa  gcc cag cta atc aga  caa atg gaa gga        9436
Thr  Phe Thr Asn Met Glu  Ala Gln Leu Ile Arg  Gln Met Glu Gly            
3100                 3105                 3110                            

gaa  ggc gtg ttg tca aag  gca gac ctc gag aac  ccc cat ccg cta        9481
Glu  Gly Val Leu Ser Lys  Ala Asp Leu Glu Asn  Pro His Pro Leu            
3115                 3120                 3125                            

gag  aag aaa att aca caa  tgg ttg gaa act aaa  gga gtg gaa agg        9526
Glu  Lys Lys Ile Thr Gln  Trp Leu Glu Thr Lys  Gly Val Glu Arg            
3130                 3135                 3140                            

tta  aaa aga atg gcc atc  agc ggg gat gat tgc  gtt gtg aaa cca        9571
Leu  Lys Arg Met Ala Ile  Ser Gly Asp Asp Cys  Val Val Lys Pro            
3145                 3150                 3155                            

atc  gac gac aga ttc gcc  aat gcc ctg ctt gcc  ctg aac gat atg        9616
Ile  Asp Asp Arg Phe Ala  Asn Ala Leu Leu Ala  Leu Asn Asp Met            
3160                 3165                 3170                            

gga  aag gtt aga aag gac  ata cct caa tgg cag  cca tca aag gga        9661
Gly  Lys Val Arg Lys Asp  Ile Pro Gln Trp Gln  Pro Ser Lys Gly            
3175                 3180                 3185                            

tgg  cat gat tgg caa cag  gtc ccc ttc tgc tcc  cac cac ttt cat        9706
Trp  His Asp Trp Gln Gln  Val Pro Phe Cys Ser  His His Phe His            
3190                 3195                 3200                            

gaa  ttg atc atg aaa gat  gga aga aag ttg gta  gtt ccc tgc aga        9751
Glu  Leu Ile Met Lys Asp  Gly Arg Lys Leu Val  Val Pro Cys Arg            
3205                 3210                 3215                            

ccc  cag gac gaa cta ata  gga aga gcg aga atc  tcc caa gga gca        9796
Pro  Gln Asp Glu Leu Ile  Gly Arg Ala Arg Ile  Ser Gln Gly Ala            
3220                 3225                 3230                            

gga  tgg agc ctt aga gaa  act gca tgt cta ggg  aaa gcc tac gct        9841
Gly  Trp Ser Leu Arg Glu  Thr Ala Cys Leu Gly  Lys Ala Tyr Ala            
3235                 3240                 3245                            

caa  atg tgg gct ctc atg  tat ttt cac aga aga  gat ctt aga cta        9886
Gln  Met Trp Ala Leu Met  Tyr Phe His Arg Arg  Asp Leu Arg Leu            
3250                 3255                 3260                            

gca  tcc aac gcc ata tgt  tca gca gta cca gtc  cac tgg gtc ccc        9931
Ala  Ser Asn Ala Ile Cys  Ser Ala Val Pro Val  His Trp Val Pro            
3265                 3270                 3275                            

acg  agc aga acg aca tgg  tct att cat gct cac  cat cag tgg atg        9976
Thr  Ser Arg Thr Thr Trp  Ser Ile His Ala His  His Gln Trp Met            
3280                 3285                 3290                            

act  aca gaa gac atg ctt  act gtc tgg aac agg  gtg tgg ata gag       10021
Thr  Thr Glu Asp Met Leu  Thr Val Trp Asn Arg  Val Trp Ile Glu            
3295                 3300                 3305                            

gac  aat cca tgg atg gaa  gac aaa act cca gtc  aca acg tgg gaa       10066
Asp  Asn Pro Trp Met Glu  Asp Lys Thr Pro Val  Thr Thr Trp Glu            
3310                 3315                 3320                            

gat  gtt cca tat cta ggg  aag aga gaa gac caa  tgg tgc gga tca       10111
Asp  Val Pro Tyr Leu Gly  Lys Arg Glu Asp Gln  Trp Cys Gly Ser            
3325                 3330                 3335                            

ctc  ata ggt ctc act tcc  aga gca acc tgg gcc  cag aac ata ctc       10156
Leu  Ile Gly Leu Thr Ser  Arg Ala Thr Trp Ala  Gln Asn Ile Leu            
3340                 3345                 3350                            

aca  gca atc caa cag gtg  aga agc ctc ata ggc  aat gaa gag ttt       10201
Thr  Ala Ile Gln Gln Val  Arg Ser Leu Ile Gly  Asn Glu Glu Phe            
3355                 3360                 3365                            

ctg  gac tac atg cct tcg  atg aag aga ttc agg  aag gag gag gag       10246
Leu  Asp Tyr Met Pro Ser  Met Lys Arg Phe Arg  Lys Glu Glu Glu            
3370                 3375                 3380                            

tca  gag gga gcc att tgg  taa aagcaggagg taaactgtca ggccacatta       10297
Ser  Glu Gly Ala Ile Trp                                                  
3385                 3390                                                 

agccacagta cggaagaagc tgtgcagcct gtgagccccg tccaaggacg ttaaaagaag    10357

aagtcaggcc caaaagccac ggtttgagca aaccgtgctg cctgtagctc cgtcgtgggg    10417

acgtaaagcc tgggaggctg caaaccgtgg aagctgtacg cacggtgtag cagactagtg    10477

gttagaggag acccctccca tgacacaacg cagcagcggg gcccgagcac tgagggaagc    10537

tgtacctcct tgcaaaggac tagaggttag aggagacccc ccgcaaacaa aaacagcata    10597

ttgacgctgg gagagaccag agatcctgct gtctcctcag catcattcca ggcacagaac    10657

gccagaaaat ggaatggtgc tgttgaatca acaggttcta gt                       10699


<210>  8
<211>  3390
<212>  PRT
<213>  Dengue virus type 3

<400>  8

Met Asn Asn Gln Arg Lys Lys Thr Gly Lys Pro Ser Ile Asn Met Leu 
1               5                   10                  15      


Lys Arg Val Arg Asn Arg Val Ser Thr Gly Ser Gln Leu Ala Lys Arg 
            20                  25                  30          


Phe Ser Arg Gly Leu Leu Asn Gly Gln Gly Pro Met Lys Leu Val Met 
        35                  40                  45              


Ala Phe Ile Ala Phe Leu Arg Phe Leu Ala Ile Pro Pro Thr Ala Gly 
    50                  55                  60                  


Val Leu Ala Arg Trp Gly Thr Phe Lys Lys Ser Gly Ala Ile Lys Val 
65                  70                  75                  80  


Leu Lys Gly Phe Lys Lys Glu Ile Ser Asn Met Leu Ser Ile Ile Asn 
                85                  90                  95      


Lys Arg Lys Lys Thr Ser Leu Cys Leu Met Met Met Leu Pro Ala Thr 
            100                 105                 110         


Leu Ala Phe His Leu Thr Ser Arg Asp Gly Glu Pro Arg Met Ile Val 
        115                 120                 125             


Gly Lys Asn Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ala Ser Gly 
    130                 135                 140                 


Ile Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Asp 
145                 150                 155                 160 


Asp Thr Val Thr Tyr Lys Cys Pro His Ile Thr Glu Val Glu Pro Glu 
                165                 170                 175     


Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Thr Tyr Gly 
            180                 185                 190         


Thr Cys Asn Gln Ala Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala 
        195                 200                 205             


Leu Ala Pro His Val Gly Met Gly Leu Asp Thr Arg Thr Gln Thr Trp 
    210                 215                 220                 


Met Ser Ala Glu Gly Ala Trp Arg Gln Val Glu Lys Val Glu Thr Trp 
225                 230                 235                 240 


Ala Leu Arg His Pro Gly Phe Thr Ile Leu Ala Leu Phe Leu Ala His 
                245                 250                 255     


Tyr Ile Gly Thr Ser Leu Thr Gln Lys Val Val Ile Phe Ile Leu Leu 
            260                 265                 270         


Met Leu Val Thr Pro Ser Met Thr Met Arg Cys Val Gly Val Gly Asn 
        275                 280                 285             


Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val 
    290                 295                 300                 


Leu Glu His Gly Gly Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr 
305                 310                 315                 320 


Leu Asp Ile Glu Leu Gln Lys Thr Glu Ala Thr Gln Leu Ala Thr Leu 
                325                 330                 335     


Arg Lys Leu Cys Ile Glu Gly Lys Ile Thr Asn Ile Thr Thr Asp Ser 
            340                 345                 350         


Arg Cys Pro Thr Gln Gly Glu Ala Ile Leu Pro Glu Glu Gln Asp Gln 
        355                 360                 365             


Asn Tyr Val Cys Lys His Thr Tyr Val Asp Arg Gly Trp Gly Asn Gly 
    370                 375                 380                 


Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Gln 
385                 390                 395                 400 


Cys Leu Glu Ser Ile Glu Gly Lys Val Val Gln His Glu Asn Leu Lys 
                405                 410                 415     


Tyr Thr Val Ile Ile Thr Val His Thr Gly Asp Gln His Gln Val Gly 
            420                 425                 430         


Asn Glu Thr Gln Gly Val Thr Ala Glu Ile Thr Pro Gln Ala Ser Thr 
        435                 440                 445             


Ala Glu Ala Ile Leu Pro Glu Tyr Gly Thr Leu Gly Leu Glu Cys Ser 
    450                 455                 460                 


Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Ile Ser Leu Thr Met Lys 
465                 470                 475                 480 


Asn Lys Ala Trp Met Val His Arg Gln Trp Phe Phe Asp Leu Pro Leu 
                485                 490                 495     


Pro Trp Thr Ser Gly Ala Thr Ala Glu Thr Pro Thr Trp Asn Arg Lys 
            500                 505                 510         


Glu Leu Leu Val Thr Phe Lys Asn Ala His Ala Lys Lys Gln Glu Val 
        515                 520                 525             


Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr Gly 
    530                 535                 540                 


Ala Thr Glu Ile Gln Thr Ser Gly Gly Thr Ser Ile Phe Ala Gly His 
545                 550                 555                 560 


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Glu Leu Lys Gly Met Ser 
                565                 570                 575     


Tyr Ala Met Cys Leu Ser Ser Phe Val Leu Lys Lys Glu Val Ser Glu 
            580                 585                 590         


Thr Gln His Gly Thr Ile Leu Ile Lys Val Glu Tyr Lys Gly Glu Asp 
        595                 600                 605             


Ala Pro Cys Lys Ile Pro Phe Ser Thr Glu Asp Gly Gln Gly Lys Ala 
    610                 615                 620                 


His Asn Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr Lys Lys Glu 
625                 630                 635                 640 


Glu Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser Asn Ile 
                645                 650                 655     


Val Ile Gly Ile Gly Asp Lys Ala Leu Lys Ile Asn Trp Tyr Lys Lys 
            660                 665                 670         


Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly Ala Arg 
        675                 680                 685             


Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly 
    690                 695                 700                 


Gly Val Leu Asn Ser Leu Gly Lys Met Val His Gln Ile Phe Gly Ser 
705                 710                 715                 720 


Ala Tyr Thr Ala Leu Phe Gly Gly Val Ser Trp Met Met Lys Ile Gly 
                725                 730                 735     


Ile Gly Val Leu Leu Thr Trp Ile Gly Leu Asn Ser Lys Asn Thr Ser 
            740                 745                 750         


Met Ser Phe Ser Cys Ile Ala Ile Gly Ile Ile Thr Leu Tyr Leu Gly 
        755                 760                 765             


Ala Val Val Gln Ala Asp Met Gly Cys Val Ile Asn Trp Lys Gly Lys 
    770                 775                 780                 


Glu Leu Lys Cys Gly Ser Gly Ile Phe Val Thr Asn Glu Val His Thr 
785                 790                 795                 800 


Trp Thr Glu Gln Tyr Lys Phe Gln Ala Asp Ser Pro Lys Arg Leu Ala 
                805                 810                 815     


Thr Ala Ile Ala Gly Ala Trp Glu Asn Gly Val Cys Gly Ile Arg Ser 
            820                 825                 830         


Thr Thr Arg Met Glu Asn Leu Leu Trp Lys Gln Ile Ala Asn Glu Leu 
        835                 840                 845             


Asn Tyr Ile Leu Trp Glu Asn Asn Ile Lys Leu Thr Val Val Val Gly 
    850                 855                 860                 


Asp Ile Thr Gly Val Leu Glu Gln Gly Lys Arg Thr Leu Thr Pro Gln 
865                 870                 875                 880 


Pro Met Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys Ile 
                885                 890                 895     


Val Thr Ala Glu Thr Gln Asn Ser Ser Phe Ile Ile Asp Gly Pro Ser 
            900                 905                 910         


Thr Pro Glu Cys Pro Ser Ala Ser Arg Ala Trp Asn Val Trp Glu Val 
        915                 920                 925             


Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu Lys Leu 
    930                 935                 940                 


Arg Glu Val Tyr Thr Gln Leu Cys Asp His Arg Leu Met Ser Ala Ala 
945                 950                 955                 960 


Val Lys Asp Glu Arg Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu 
                965                 970                 975     


Ser Gln Lys Asn Gly Ser Trp Lys Leu Glu Lys Ala Ser Phe Ile Glu 
            980                 985                 990         


Val Lys Thr Cys Thr Trp Pro Lys  Ser His Thr Leu Trp  Ser Asn Gly 
        995                 1000                 1005             


Val Leu  Glu Ser Asp Met Ile  Ile Pro Lys Ser Leu  Ala Gly Pro 
    1010                 1015                 1020             


Ile Ser  Gln His Asn His Arg  Pro Gly Tyr His Thr  Gln Thr Ala 
    1025                 1030                 1035             


Gly Pro  Trp His Leu Gly Lys  Leu Glu Leu Asp Phe  Asn Tyr Cys 
    1040                 1045                 1050             


Glu Gly  Thr Thr Val Val Ile  Ser Glu Asn Cys Gly  Thr Arg Gly 
    1055                 1060                 1065             


Pro Ser  Leu Arg Thr Thr Thr  Val Ser Gly Lys Leu  Ile His Glu 
    1070                 1075                 1080             


Trp Cys  Cys Arg Ser Cys Thr  Leu Pro Pro Leu Arg  Tyr Met Gly 
    1085                 1090                 1095             


Glu Asp  Gly Cys Trp Tyr Gly  Met Glu Ile Arg Pro  Ile Asn Glu 
    1100                 1105                 1110             


Lys Glu  Glu Asn Met Val Lys  Ser Leu Ala Ser Ala  Gly Ser Gly 
    1115                 1120                 1125             


Lys Val  Asp Asn Phe Thr Met  Gly Val Leu Cys Leu  Ala Ile Leu 
    1130                 1135                 1140             


Phe Glu  Glu Val Met Arg Gly  Lys Phe Gly Lys Lys  His Met Ile 
    1145                 1150                 1155             


Ala Gly  Val Leu Phe Thr Phe  Val Leu Leu Leu Ser  Gly Gln Ile 
    1160                 1165                 1170             


Thr Trp  Arg Asp Met Ala His  Thr Leu Ile Met Ile  Gly Ser Asn 
    1175                 1180                 1185             


Ala Ser  Asp Arg Met Gly Met  Gly Val Thr Tyr Leu  Ala Leu Ile 
    1190                 1195                 1200             


Ala Thr  Phe Lys Ile Gln Pro  Phe Leu Ala Leu Gly  Phe Phe Leu 
    1205                 1210                 1215             


Arg Lys  Leu Thr Ser Arg Glu  Asn Leu Leu Leu Gly  Val Gly Leu 
    1220                 1225                 1230             


Ala Met  Ala Ala Thr Leu Arg  Leu Pro Glu Asp Ile  Glu Gln Met 
    1235                 1240                 1245             


Ala Asn  Gly Ile Ala Leu Gly  Leu Met Ala Leu Lys  Leu Ile Thr 
    1250                 1255                 1260             


Gln Phe  Glu Thr Tyr Gln Leu  Trp Thr Ala Leu Val  Ser Leu Thr 
    1265                 1270                 1275             


Cys Ser  Asn Thr Ile Phe Thr  Leu Thr Val Ala Trp  Arg Thr Ala 
    1280                 1285                 1290             


Thr Leu  Ile Leu Ala Gly Ile  Ser Leu Leu Pro Val  Cys Gln Ser 
    1295                 1300                 1305             


Ser Ser  Met Arg Lys Thr Asp  Trp Leu Pro Met Thr  Val Ala Ala 
    1310                 1315                 1320             


Met Gly  Ala Gln Pro Leu Pro  Leu Phe Ile Phe Ser  Leu Lys Asp 
    1325                 1330                 1335             


Thr Leu  Lys Arg Arg Ser Trp  Pro Leu Asn Glu Gly  Val Met Ala 
    1340                 1345                 1350             


Val Gly  Leu Val Ser Ile Leu  Ala Ser Ser Leu Leu  Arg Asn Asp 
    1355                 1360                 1365             


Val Pro  Met Ala Gly Pro Leu  Val Ala Gly Gly Leu  Leu Ile Ala 
    1370                 1375                 1380             


Cys Tyr  Val Ile Thr Gly Thr  Ser Ala Asp Leu Thr  Val Glu Lys 
    1385                 1390                 1395             


Ala Ala  Asp Val Thr Trp Glu  Glu Glu Ala Glu Gln  Thr Gly Val 
    1400                 1405                 1410             


Ser His  Asn Leu Met Val Thr  Val Asp Asp Asp Gly  Thr Met Arg 
    1415                 1420                 1425             


Ile Lys  Asp Asp Glu Thr Glu  Asn Ile Leu Thr Val  Leu Leu Lys 
    1430                 1435                 1440             


Thr Ala  Leu Leu Ile Val Ser  Gly Ile Phe Pro Tyr  Ser Ile Pro 
    1445                 1450                 1455             


Ala Thr  Leu Leu Val Trp His  Thr Trp Gln Lys Gln  Thr Gln Arg 
    1460                 1465                 1470             


Ser Gly  Val Leu Trp Asp Val  Pro Ser Pro Pro Glu  Thr Gln Lys 
    1475                 1480                 1485             


Ala Glu  Leu Glu Glu Gly Val  Tyr Arg Ile Lys Gln  Gln Gly Ile 
    1490                 1495                 1500             


Phe Gly  Lys Thr Gln Val Gly  Val Gly Val Gln Lys  Glu Gly Val 
    1505                 1510                 1515             


Phe His  Thr Met Trp His Val  Thr Arg Gly Ala Val  Leu Thr His 
    1520                 1525                 1530             


Asn Gly  Lys Arg Leu Glu Pro  Asn Trp Ala Ser Val  Lys Lys Asp 
    1535                 1540                 1545             


Leu Ile  Ser Tyr Gly Gly Gly  Trp Arg Leu Ser Ala  Gln Trp Gln 
    1550                 1555                 1560             


Lys Gly  Glu Glu Val Gln Val  Ile Ala Val Glu Pro  Gly Lys Asn 
    1565                 1570                 1575             


Pro Lys  Asn Phe Gln Thr Met  Pro Gly Ile Phe Gln  Thr Thr Thr 
    1580                 1585                 1590             


Gly Glu  Ile Gly Ala Ile Ala  Leu Asp Phe Lys Pro  Gly Thr Ser 
    1595                 1600                 1605             


Gly Ser  Pro Ile Ile Asn Arg  Glu Gly Lys Val Val  Gly Leu Tyr 
    1610                 1615                 1620             


Gly Asn  Gly Val Val Thr Lys  Asn Gly Gly Tyr Val  Ser Gly Ile 
    1625                 1630                 1635             


Ala Gln  Thr Asn Ala Glu Pro  Asp Gly Pro Thr Pro  Glu Leu Glu 
    1640                 1645                 1650             


Glu Glu  Met Phe Lys Lys Arg  Asn Leu Thr Ile Met  Asp Leu His 
    1655                 1660                 1665             


Pro Gly  Ser Gly Lys Thr Arg  Lys Tyr Leu Pro Ala  Ile Val Arg 
    1670                 1675                 1680             


Glu Ala  Ile Lys Arg Arg Leu  Arg Thr Leu Ile Leu  Ala Pro Thr 
    1685                 1690                 1695             


Arg Val  Val Ala Ala Glu Met  Glu Glu Ala Leu Lys  Gly Leu Pro 
    1700                 1705                 1710             


Ile Arg  Tyr Gln Thr Thr Ala  Thr Lys Ser Glu His  Thr Gly Arg 
    1715                 1720                 1725             


Glu Ile  Val Asp Leu Met Cys  His Ala Thr Phe Thr  Met Arg Leu 
    1730                 1735                 1740             


Leu Ser  Pro Val Arg Val Pro  Asn Tyr Asn Leu Ile  Ile Met Asp 
    1745                 1750                 1755             


Glu Ala  His Phe Thr Asp Pro  Ala Ser Ile Ala Ala  Arg Gly Tyr 
    1760                 1765                 1770             


Ile Ser  Thr Arg Val Gly Met  Gly Glu Ala Ala Ala  Ile Phe Met 
    1775                 1780                 1785             


Thr Ala  Thr Pro Pro Gly Thr  Ala Asp Ala Phe Pro  Gln Ser Asn 
    1790                 1795                 1800             


Ala Pro  Ile Gln Asp Glu Glu  Arg Asp Ile Pro Glu  Arg Ser Trp 
    1805                 1810                 1815             


Asn Ser  Gly Asn Glu Trp Ile  Thr Asp Phe Val Gly  Lys Thr Val 
    1820                 1825                 1830             


Trp Phe  Val Pro Ser Ile Lys  Ala Gly Asn Asp Ile  Ala Asn Cys 
    1835                 1840                 1845             


Leu Arg  Lys Asn Gly Lys Lys  Val Ile Gln Leu Ser  Arg Lys Thr 
    1850                 1855                 1860             


Phe Asp  Thr Glu Tyr Gln Lys  Thr Lys Leu Asn Asp  Trp Asp Phe 
    1865                 1870                 1875             


Val Val  Thr Thr Asp Ile Ser  Glu Met Gly Ala Asn  Phe Lys Ala 
    1880                 1885                 1890             


Asp Arg  Val Ile Asp Pro Arg  Arg Cys Leu Lys Pro  Val Ile Leu 
    1895                 1900                 1905             


Thr Asp  Gly Pro Glu Arg Val  Ile Leu Ala Gly Pro  Met Pro Val 
    1910                 1915                 1920             


Thr Val  Ala Ser Ala Ala Gln  Arg Arg Gly Arg Val  Gly Arg Asn 
    1925                 1930                 1935             


Pro Gln  Lys Glu Asn Asp Gln  Tyr Ile Phe Met Gly  Gln Pro Leu 
    1940                 1945                 1950             


Asn Asn  Asp Glu Asp His Ala  His Trp Thr Glu Ala  Lys Met Leu 
    1955                 1960                 1965             


Leu Asp  Asn Ile Asn Thr Pro  Glu Gly Ile Ile Pro  Ala Leu Phe 
    1970                 1975                 1980             


Glu Pro  Glu Arg Glu Lys Ser  Ala Ala Ile Asp Gly  Glu Tyr Arg 
    1985                 1990                 1995             


Leu Lys  Gly Glu Ser Arg Lys  Thr Phe Val Glu Leu  Met Arg Arg 
    2000                 2005                 2010             


Gly Asp  Leu Pro Val Trp Leu  Ala His Lys Val Ala  Ser Glu Gly 
    2015                 2020                 2025             


Ile Lys  Tyr Thr Asp Arg Lys  Trp Cys Phe Asp Gly  Glu Arg Asn 
    2030                 2035                 2040             


Asn Gln  Ile Leu Glu Glu Asn  Met Asp Val Glu Ile  Trp Thr Lys 
    2045                 2050                 2055             


Glu Gly  Glu Lys Lys Lys Leu  Arg Pro Arg Trp Leu  Asp Ala Arg 
    2060                 2065                 2070             


Thr Tyr  Ser Asp Pro Leu Ala  Leu Lys Glu Phe Lys  Asp Phe Ala 
    2075                 2080                 2085             


Ala Gly  Arg Lys Ser Ile Ala  Leu Asp Leu Val Thr  Glu Ile Gly 
    2090                 2095                 2100             


Arg Val  Pro Ser His Leu Ala  His Arg Thr Arg Asn  Ala Leu Asp 
    2105                 2110                 2115             


Asn Leu  Val Met Leu His Thr  Ser Glu His Gly Gly  Arg Ala Tyr 
    2120                 2125                 2130             


Arg His  Ala Val Glu Glu Leu  Pro Glu Thr Met Glu  Thr Leu Leu 
    2135                 2140                 2145             


Leu Leu  Gly Leu Met Ile Leu  Leu Thr Gly Gly Ala  Met Leu Phe 
    2150                 2155                 2160             


Leu Ile  Ser Gly Lys Gly Ile  Gly Lys Thr Ser Ile  Gly Leu Ile 
    2165                 2170                 2175             


Cys Val  Ile Ala Ser Ser Gly  Met Leu Trp Met Ala  Asp Val Pro 
    2180                 2185                 2190             


Leu Gln  Trp Ile Ala Ser Ala  Ile Val Leu Glu Phe  Phe Met Met 
    2195                 2200                 2205             


Val Leu  Leu Ile Pro Glu Pro  Glu Lys Gln Arg Thr  Pro Gln Asp 
    2210                 2215                 2220             


Asn Gln  Leu Ala Tyr Val Val  Ile Gly Ile Leu Thr  Leu Ala Ala 
    2225                 2230                 2235             


Ile Val  Ala Ala Asn Glu Met  Gly Leu Leu Glu Thr  Thr Lys Arg 
    2240                 2245                 2250             


Asp Leu  Gly Met Ser Lys Glu  Pro Gly Val Val Ser  Pro Thr Ser 
    2255                 2260                 2265             


Tyr Leu  Asp Val Asp Leu His  Pro Ala Ser Ala Trp  Thr Leu Tyr 
    2270                 2275                 2280             


Ala Val  Ala Thr Thr Val Ile  Thr Pro Met Leu Arg  His Thr Ile 
    2285                 2290                 2295             


Glu Asn  Ser Thr Ala Asn Val  Ser Leu Ala Ala Ile  Ala Asn Gln 
    2300                 2305                 2310             


Ala Val  Val Leu Met Gly Leu  Asp Lys Gly Trp Pro  Ile Ser Lys 
    2315                 2320                 2325             


Met Asp  Leu Gly Val Pro Leu  Leu Ala Leu Gly Cys  Tyr Ser Gln 
    2330                 2335                 2340             


Val Asn  Pro Leu Thr Leu Ala  Ala Ala Val Leu Leu  Leu Val Thr 
    2345                 2350                 2355             


His Tyr  Ala Ile Ile Gly Pro  Gly Leu Gln Ala Lys  Ala Thr Arg 
    2360                 2365                 2370             


Glu Ala  Gln Lys Arg Thr Ala  Ala Gly Ile Met Lys  Asn Pro Thr 
    2375                 2380                 2385             


Val Asp  Gly Ile Met Thr Ile  Asp Leu Asp Pro Val  Ile Tyr Asp 
    2390                 2395                 2400             


Ser Lys  Phe Glu Lys Gln Leu  Gly Gln Val Met Leu  Leu Val Leu 
    2405                 2410                 2415             


Cys Ala  Val Gln Leu Leu Leu  Met Arg Thr Ser Trp  Ala Leu Cys 
    2420                 2425                 2430             


Glu Val  Leu Thr Leu Ala Thr  Gly Pro Ile Thr Thr  Leu Trp Glu 
    2435                 2440                 2445             


Gly Ser  Pro Gly Lys Phe Trp  Asn Thr Thr Ile Ala  Val Ser Met 
    2450                 2455                 2460             


Ala Asn  Ile Phe Arg Gly Ser  Tyr Leu Ala Gly Ala  Gly Leu Ala 
    2465                 2470                 2475             


Phe Ser  Ile Met Lys Ser Val  Gly Thr Gly Lys Arg  Gly Thr Gly 
    2480                 2485                 2490             


Ser Gln  Gly Glu Thr Leu Gly  Glu Lys Trp Lys Lys  Lys Leu Asn 
    2495                 2500                 2505             


Gln Leu  Ser Arg Lys Glu Phe  Asp Leu Tyr Lys Lys  Ser Gly Ile 
    2510                 2515                 2520             


Thr Glu  Val Asp Arg Thr Glu  Ala Lys Glu Gly Leu  Lys Arg Gly 
    2525                 2530                 2535             


Glu Ile  Thr His His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Gln 
    2540                 2545                 2550             


Trp Phe  Val Glu Arg Asn Met  Val Ile Pro Glu Gly  Arg Val Ile 
    2555                 2560                 2565             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Cys Ala Gly 
    2570                 2575                 2580             


Leu Lys  Lys Val Thr Glu Val  Arg Gly Tyr Thr Lys  Gly Gly Pro 
    2585                 2590                 2595             


Gly His  Glu Glu Pro Val Pro  Met Ser Thr Tyr Gly  Trp Asn Ile 
    2600                 2605                 2610             


Val Lys  Leu Met Ser Gly Lys  Asp Val Phe Tyr Leu  Pro Pro Glu 
    2615                 2620                 2625             


Lys Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Pro Ser 
    2630                 2635                 2640             


Pro Thr  Val Glu Glu Ser Arg  Thr Ile Arg Val Leu  Lys Met Val 
    2645                 2650                 2655             


Glu Pro  Trp Leu Lys Asn Asn  Gln Phe Cys Ile Lys  Val Leu Asn 
    2660                 2665                 2670             


Pro Tyr  Met Pro Thr Val Ile  Glu His Leu Glu Arg  Leu Gln Arg 
    2675                 2680                 2685             


Lys His  Gly Gly Met Leu Val  Arg Asn Pro Leu Ser  Arg Asn Ser 
    2690                 2695                 2700             


Thr His  Glu Met Tyr Trp Ile  Ser Asn Gly Thr Gly  Asn Ile Val 
    2705                 2710                 2715             


Ser Ser  Val Asn Met Val Ser  Arg Leu Leu Leu Asn  Arg Phe Thr 
    2720                 2725                 2730             


Met Thr  His Arg Arg Pro Thr  Ile Glu Lys Asp Val  Asp Leu Gly 
    2735                 2740                 2745             


Ala Gly  Thr Arg His Val Asn  Ala Glu Pro Glu Thr  Pro Asn Met 
    2750                 2755                 2760             


Asp Val  Ile Gly Glu Arg Ile  Lys Arg Ile Lys Glu  Glu His Ser 
    2765                 2770                 2775             


Ser Thr  Trp His Tyr Asp Asp  Glu Asn Pro Tyr Lys  Thr Trp Ala 
    2780                 2785                 2790             


Tyr His  Gly Ser Tyr Glu Val  Lys Ala Thr Gly Ser  Ala Ser Ser 
    2795                 2800                 2805             


Met Ile  Asn Gly Val Val Lys  Leu Leu Thr Lys Pro  Trp Asp Val 
    2810                 2815                 2820             


Val Pro  Met Val Thr Gln Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2825                 2830                 2835             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Arg Thr Pro 
    2840                 2845                 2850             


Arg Pro  Met Pro Gly Thr Arg  Lys Val Met Glu Ile  Thr Ala Glu 
    2855                 2860                 2865             


Trp Leu  Trp Arg Thr Leu Gly  Arg Asn Lys Arg Pro  Arg Leu Cys 
    2870                 2875                 2880             


Thr Arg  Glu Glu Phe Thr Lys  Lys Val Arg Thr Asn  Ala Ala Met 
    2885                 2890                 2895             


Gly Ala  Val Phe Thr Glu Glu  Asn Gln Trp Asp Ser  Ala Arg Ala 
    2900                 2905                 2910             


Ala Val  Glu Asp Glu Glu Phe  Trp Lys Leu Val Asp  Arg Glu Arg 
    2915                 2920                 2925             


Glu Leu  His Lys Leu Gly Lys  Cys Gly Ser Cys Val  Tyr Asn Met 
    2930                 2935                 2940             


Met Gly  Lys Arg Glu Lys Lys  Leu Gly Glu Phe Gly  Lys Ala Lys 
    2945                 2950                 2955             


Gly Ser  Arg Ala Ile Trp Tyr  Met Trp Leu Gly Ala  Arg Tyr Leu 
    2960                 2965                 2970             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Phe Ser 
    2975                 2980                 2985             


Arg Glu  Asn Ser Tyr Ser Gly  Val Glu Gly Glu Gly  Leu His Lys 
    2990                 2995                 3000             


Leu Gly  Tyr Ile Leu Arg Asp  Ile Ser Lys Ile Pro  Gly Gly Ala 
    3005                 3010                 3015             


Met Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Glu 
    3020                 3025                 3030             


Asp Asp  Leu His Asn Glu Glu  Lys Ile Thr Gln Gln  Met Asp Pro 
    3035                 3040                 3045             


Glu His  Arg Gln Leu Ala Asn  Ala Ile Phe Lys Leu  Thr Tyr Gln 
    3050                 3055                 3060             


Asn Lys  Val Val Lys Val Gln  Arg Pro Thr Pro Lys  Gly Thr Val 
    3065                 3070                 3075             


Met Asp  Ile Ile Ser Arg Lys  Asp Gln Arg Gly Ser  Gly Gln Val 
    3080                 3085                 3090             


Gly Thr  Tyr Gly Leu Asn Thr  Phe Thr Asn Met Glu  Ala Gln Leu 
    3095                 3100                 3105             


Ile Arg  Gln Met Glu Gly Glu  Gly Val Leu Ser Lys  Ala Asp Leu 
    3110                 3115                 3120             


Glu Asn  Pro His Pro Leu Glu  Lys Lys Ile Thr Gln  Trp Leu Glu 
    3125                 3130                 3135             


Thr Lys  Gly Val Glu Arg Leu  Lys Arg Met Ala Ile  Ser Gly Asp 
    3140                 3145                 3150             


Asp Cys  Val Val Lys Pro Ile  Asp Asp Arg Phe Ala  Asn Ala Leu 
    3155                 3160                 3165             


Leu Ala  Leu Asn Asp Met Gly  Lys Val Arg Lys Asp  Ile Pro Gln 
    3170                 3175                 3180             


Trp Gln  Pro Ser Lys Gly Trp  His Asp Trp Gln Gln  Val Pro Phe 
    3185                 3190                 3195             


Cys Ser  His His Phe His Glu  Leu Ile Met Lys Asp  Gly Arg Lys 
    3200                 3205                 3210             


Leu Val  Val Pro Cys Arg Pro  Gln Asp Glu Leu Ile  Gly Arg Ala 
    3215                 3220                 3225             


Arg Ile  Ser Gln Gly Ala Gly  Trp Ser Leu Arg Glu  Thr Ala Cys 
    3230                 3235                 3240             


Leu Gly  Lys Ala Tyr Ala Gln  Met Trp Ala Leu Met  Tyr Phe His 
    3245                 3250                 3255             


Arg Arg  Asp Leu Arg Leu Ala  Ser Asn Ala Ile Cys  Ser Ala Val 
    3260                 3265                 3270             


Pro Val  His Trp Val Pro Thr  Ser Arg Thr Thr Trp  Ser Ile His 
    3275                 3280                 3285             


Ala His  His Gln Trp Met Thr  Thr Glu Asp Met Leu  Thr Val Trp 
    3290                 3295                 3300             


Asn Arg  Val Trp Ile Glu Asp  Asn Pro Trp Met Glu  Asp Lys Thr 
    3305                 3310                 3315             


Pro Val  Thr Thr Trp Glu Asp  Val Pro Tyr Leu Gly  Lys Arg Glu 
    3320                 3325                 3330             


Asp Gln  Trp Cys Gly Ser Leu  Ile Gly Leu Thr Ser  Arg Ala Thr 
    3335                 3340                 3345             


Trp Ala  Gln Asn Ile Leu Thr  Ala Ile Gln Gln Val  Arg Ser Leu 
    3350                 3355                 3360             


Ile Gly  Asn Glu Glu Phe Leu  Asp Tyr Met Pro Ser  Met Lys Arg 
    3365                 3370                 3375             


Phe Arg  Lys Glu Glu Glu Ser  Glu Gly Ala Ile Trp  
    3380                 3385                 3390 


<210>  9
<211>  10648
<212>  DNA
<213>  Dengue virus type 4


<220>
<221>  CDS
<222>  (102)..(10265)

<400>  9
agttgttagt ctgtgtggac cgacaaggac agttccaaat cggaagcttg cttaacacag       60

ttctaacagt ttgtttgaat agagagcaga tctctggaaa a atg aac caa cga aaa      116
                                              Met Asn Gln Arg Lys         
                                              1               5           

aag gtg gtt aga cca cct ttc aat atg ctg aaa cgc gag aga aac cgc        164
Lys Val Val Arg Pro Pro Phe Asn Met Leu Lys Arg Glu Arg Asn Arg           
                10                  15                  20                

gta tca acc cct caa ggg ttg gtg aag aga ttc tca acc gga ctt ttt        212
Val Ser Thr Pro Gln Gly Leu Val Lys Arg Phe Ser Thr Gly Leu Phe           
            25                  30                  35                    

tct ggg aaa gga ccc tta cgg atg gtg cta gca ttc atc acg ttt ttg        260
Ser Gly Lys Gly Pro Leu Arg Met Val Leu Ala Phe Ile Thr Phe Leu           
        40                  45                  50                        

cga gtc ctt tcc atc cca cca aca gca ggg att ctg aaa aga tgg gga        308
Arg Val Leu Ser Ile Pro Pro Thr Ala Gly Ile Leu Lys Arg Trp Gly           
    55                  60                  65                            

cag ttg aag aaa aat aag gcc atc agg ata ctg att gga ttc agg aag        356
Gln Leu Lys Lys Asn Lys Ala Ile Arg Ile Leu Ile Gly Phe Arg Lys           
70                  75                  80                  85            

gag ata ggc cgc atg ctg aac atc ttg aac ggg aga aaa agg tca acg        404
Glu Ile Gly Arg Met Leu Asn Ile Leu Asn Gly Arg Lys Arg Ser Thr           
                90                  95                  100               

ata aca ttg ctg tgc ttg att ccc acc gta atg gcg ttt cac ttg tca        452
Ile Thr Leu Leu Cys Leu Ile Pro Thr Val Met Ala Phe His Leu Ser           
            105                 110                 115                   

aca aga gat ggc gaa ccc ctc atg ata gtg gca aaa cat gaa agg ggg        500
Thr Arg Asp Gly Glu Pro Leu Met Ile Val Ala Lys His Glu Arg Gly           
        120                 125                 130                       

aga cct ctc ttg ttt aag aca aca gag ggg atc aac aaa tgc act ctc        548
Arg Pro Leu Leu Phe Lys Thr Thr Glu Gly Ile Asn Lys Cys Thr Leu           
    135                 140                 145                           

att gcc atg gac ttg ggt gaa atg tgt gag gac act gtc acg tat aaa        596
Ile Ala Met Asp Leu Gly Glu Met Cys Glu Asp Thr Val Thr Tyr Lys           
150                 155                 160                 165           

tgc ccc tta ctg gtc aat acc gaa cct gaa gac att gat tgc tgg tgc        644
Cys Pro Leu Leu Val Asn Thr Glu Pro Glu Asp Ile Asp Cys Trp Cys           
                170                 175                 180               

aat ctc acg tct acc tgg gtc atg tat ggg aca tgc acc cag agc gga        692
Asn Leu Thr Ser Thr Trp Val Met Tyr Gly Thr Cys Thr Gln Ser Gly           
            185                 190                 195                   

gaa cgg aga cga gag aag cgc tca gta gct tta aca cca cat tca gga        740
Glu Arg Arg Arg Glu Lys Arg Ser Val Ala Leu Thr Pro His Ser Gly           
        200                 205                 210                       

atg gga ttg gaa aca aga gct gag aca tgg atg tca tcg gaa ggg gct        788
Met Gly Leu Glu Thr Arg Ala Glu Thr Trp Met Ser Ser Glu Gly Ala           
    215                 220                 225                           

tgg aag cat gct cag aga gta gag agc tgg ata ctc aga aac cca gga        836
Trp Lys His Ala Gln Arg Val Glu Ser Trp Ile Leu Arg Asn Pro Gly           
230                 235                 240                 245           

ttc gcg ctc ttg gca gga ttt atg gct tat atg att ggg caa aca gga        884
Phe Ala Leu Leu Ala Gly Phe Met Ala Tyr Met Ile Gly Gln Thr Gly           
                250                 255                 260               

atc cag cga act gtc ttc ttt gtc cta atg atg ctg gtc gcc cca tcc        932
Ile Gln Arg Thr Val Phe Phe Val Leu Met Met Leu Val Ala Pro Ser           
            265                 270                 275                   

tac gga atg cga tgc gta gga gta gga aac aga gac ttt gtg gaa gga        980
Tyr Gly Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly           
        280                 285                 290                       

gtc tca ggt gga gca tgg gtc gat ctg gtg cta gaa cat gga gga tgc       1028
Val Ser Gly Gly Ala Trp Val Asp Leu Val Leu Glu His Gly Gly Cys           
    295                 300                 305                           

gtc aca acc atg gcc cag gga aaa cca acc ttg gat ttt gaa ctg act       1076
Val Thr Thr Met Ala Gln Gly Lys Pro Thr Leu Asp Phe Glu Leu Thr           
310                 315                 320                 325           

aag aca aca gcc aag gaa gtg gct ctg tta aga acc tat tgc att gaa       1124
Lys Thr Thr Ala Lys Glu Val Ala Leu Leu Arg Thr Tyr Cys Ile Glu           
                330                 335                 340               

gcc tca ata tca aac ata acc acg gca aca aga tgt cca acg caa gga       1172
Ala Ser Ile Ser Asn Ile Thr Thr Ala Thr Arg Cys Pro Thr Gln Gly           
            345                 350                 355                   

gag cct tat cta aaa gag gaa caa gac caa cag tac att tgc cgg aga       1220
Glu Pro Tyr Leu Lys Glu Glu Gln Asp Gln Gln Tyr Ile Cys Arg Arg           
        360                 365                 370                       

gat gtg gta gac aga ggg tgg ggc aat ggc tgt ggc ttg ttt gga aaa       1268
Asp Val Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys           
    375                 380                 385                           

gga gga gtt gtg aca tgt gcg aag ttt tca tgt tcg ggg aag ata aca       1316
Gly Gly Val Val Thr Cys Ala Lys Phe Ser Cys Ser Gly Lys Ile Thr           
390                 395                 400                 405           

ggc aat ttg gtc caa att gag aac ctt gaa tac aca gtg gtt gta aca       1364
Gly Asn Leu Val Gln Ile Glu Asn Leu Glu Tyr Thr Val Val Val Thr           
                410                 415                 420               

gtc cac aat gga gac acc cat gca gta gga aat gac aca tcc aat cat       1412
Val His Asn Gly Asp Thr His Ala Val Gly Asn Asp Thr Ser Asn His           
            425                 430                 435                   

gga gtt aca gcc acg ata act ccc agg tca cca tcg gtg gaa gtc aaa       1460
Gly Val Thr Ala Thr Ile Thr Pro Arg Ser Pro Ser Val Glu Val Lys           
        440                 445                 450                       

ttg ccg gac tat gga gaa cta aca ctc gat tgt gaa ccc agg tct gga       1508
Leu Pro Asp Tyr Gly Glu Leu Thr Leu Asp Cys Glu Pro Arg Ser Gly           
    455                 460                 465                           

att gac ttt aat gag atg att ctg atg aaa atg aaa aag aaa aca tgg       1556
Ile Asp Phe Asn Glu Met Ile Leu Met Lys Met Lys Lys Lys Thr Trp           
470                 475                 480                 485           

ctt gtg cat aag caa tgg ttt ttg gat cta cct cta cca tgg aca gca       1604
Leu Val His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ala           
                490                 495                 500               

gga gca gac aca tca gag gtt cac tgg aat tac aaa gag aga atg gtg       1652
Gly Ala Asp Thr Ser Glu Val His Trp Asn Tyr Lys Glu Arg Met Val           
            505                 510                 515                   

aca ttt aag gtt cct cat gcc aag aga cag gat gtg aca gtg ctg gga       1700
Thr Phe Lys Val Pro His Ala Lys Arg Gln Asp Val Thr Val Leu Gly           
        520                 525                 530                       

tct cag gaa gga gcc atg cat tct gcc ctc gct gga gcc aca gaa gtg       1748
Ser Gln Glu Gly Ala Met His Ser Ala Leu Ala Gly Ala Thr Glu Val           
    535                 540                 545                           

gac tcc ggt gat gga aat cac atg ttt gca gga cat ctc aag tgc aaa       1796
Asp Ser Gly Asp Gly Asn His Met Phe Ala Gly His Leu Lys Cys Lys           
550                 555                 560                 565           

gtc cgt atg gag aaa ttg aga atc aag gga atg tca tac acg atg tgt       1844
Val Arg Met Glu Lys Leu Arg Ile Lys Gly Met Ser Tyr Thr Met Cys           
                570                 575                 580               

tca gga aag ttc tca att gac aaa gag atg gca gaa aca cag cat ggg       1892
Ser Gly Lys Phe Ser Ile Asp Lys Glu Met Ala Glu Thr Gln His Gly           
            585                 590                 595                   

aca aca gtg gtg aaa gtc aag tat gaa ggt gct gga gct ccg tgt aaa       1940
Thr Thr Val Val Lys Val Lys Tyr Glu Gly Ala Gly Ala Pro Cys Lys           
        600                 605                 610                       

gtc ccc ata gag ata aga gat gtg aac aag gaa aaa gtg gtt ggg cgt       1988
Val Pro Ile Glu Ile Arg Asp Val Asn Lys Glu Lys Val Val Gly Arg           
    615                 620                 625                           

atc atc tca tcc acc cct ttg gct gag aat acc aac agt gca acc aac       2036
Ile Ile Ser Ser Thr Pro Leu Ala Glu Asn Thr Asn Ser Ala Thr Asn           
630                 635                 640                 645           

ata gag tta gaa ccc ccc ttt ggg gac agc tac ata gtg ata ggt gtt       2084
Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val           
                650                 655                 660               

gga aac agt gca tta aca ctc cat tgg ttc agg aaa ggg agt tcc att       2132
Gly Asn Ser Ala Leu Thr Leu His Trp Phe Arg Lys Gly Ser Ser Ile           
            665                 670                 675                   

ggc aag atg ttt gag tcc aca tac aga ggt gca aaa cga atg gcc att       2180
Gly Lys Met Phe Glu Ser Thr Tyr Arg Gly Ala Lys Arg Met Ala Ile           
        680                 685                 690                       

cta ggt gaa aca gct tgg gat ttt ggt tcc gtt ggt gga ctg ttc aca       2228
Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Leu Phe Thr           
    695                 700                 705                           

tca ttg gga aag gct gtg cac cag gtt ttt gga agt gtg tat aca acc       2276
Ser Leu Gly Lys Ala Val His Gln Val Phe Gly Ser Val Tyr Thr Thr           
710                 715                 720                 725           

atg ttt gga gga gtc tca tgg atg att aga atc cta att ggg ttc cta       2324
Met Phe Gly Gly Val Ser Trp Met Ile Arg Ile Leu Ile Gly Phe Leu           
                730                 735                 740               

gtg ttg tgg att ggc acg aac tca agg aac act tca atg gct atg acg       2372
Val Leu Trp Ile Gly Thr Asn Ser Arg Asn Thr Ser Met Ala Met Thr           
            745                 750                 755                   

tgc ata gct gtt gga gga atc act ctg ttt ctg ggc ttc aca gtt caa       2420
Cys Ile Ala Val Gly Gly Ile Thr Leu Phe Leu Gly Phe Thr Val Gln           
        760                 765                 770                       

gca gac atg ggt tgt gtg gtg tca tgg agt ggg aaa gaa ttg aag tgt       2468
Ala Asp Met Gly Cys Val Val Ser Trp Ser Gly Lys Glu Leu Lys Cys           
    775                 780                 785                           

gga agc gga att ttt gtg gtt gac aac gtg cac act tgg aca gaa cag       2516
Gly Ser Gly Ile Phe Val Val Asp Asn Val His Thr Trp Thr Glu Gln           
790                 795                 800                 805           

tac aaa ttt caa ccg gag tcc cca gcg aga cta gcg tct gca ata ttg       2564
Tyr Lys Phe Gln Pro Glu Ser Pro Ala Arg Leu Ala Ser Ala Ile Leu           
                810                 815                 820               

aat gcc cac aaa gat ggg gtc tgt gga att aga tca acc acg agg ctg       2612
Asn Ala His Lys Asp Gly Val Cys Gly Ile Arg Ser Thr Thr Arg Leu           
            825                 830                 835                   

gaa aat gtc atg tgg aag caa ata acc aac gag cta aat tat gtt ctc       2660
Glu Asn Val Met Trp Lys Gln Ile Thr Asn Glu Leu Asn Tyr Val Leu           
        840                 845                 850                       

tgg gaa gga gga cat gac ctc act gta gtg gct ggg gat gtg aag ggg       2708
Trp Glu Gly Gly His Asp Leu Thr Val Val Ala Gly Asp Val Lys Gly           
    855                 860                 865                           

gtg ttg acc aaa ggc aag aga gca ctc aca ccc cca gtg aat gat ctg       2756
Val Leu Thr Lys Gly Lys Arg Ala Leu Thr Pro Pro Val Asn Asp Leu           
870                 875                 880                 885           

aaa tat tca tgg aag aca tgg gga aaa gca aaa atc ttc acc cca gaa       2804
Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys Ile Phe Thr Pro Glu           
                890                 895                 900               

gca aga aat agc aca ttt tta ata gac gga cca gac acc tcc gaa tgc       2852
Ala Arg Asn Ser Thr Phe Leu Ile Asp Gly Pro Asp Thr Ser Glu Cys           
            905                 910                 915                   

ccc aat gaa cga aga gca tgg aac ttt ctt gag gtg gaa gac tat gga       2900
Pro Asn Glu Arg Arg Ala Trp Asn Phe Leu Glu Val Glu Asp Tyr Gly           
        920                 925                 930                       

ttt ggc atg ttc acg acc aac ata tgg atg aaa ttc cga gaa gga agt       2948
Phe Gly Met Phe Thr Thr Asn Ile Trp Met Lys Phe Arg Glu Gly Ser           
    935                 940                 945                           

tca gaa gtg tgt gac cac agg tta atg tca gcg gca att aaa gat cag       2996
Ser Glu Val Cys Asp His Arg Leu Met Ser Ala Ala Ile Lys Asp Gln           
950                 955                 960                 965           

aaa gct gtg cat gct gac atg ggt tat tgg ata gag agc tca aaa aac       3044
Lys Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu Ser Ser Lys Asn           
                970                 975                 980               

cag acc tgg cag ata gag aaa gca tct ctt att gaa gtg aaa aca tgt       3092
Gln Thr Trp Gln Ile Glu Lys Ala Ser Leu Ile Glu Val Lys Thr Cys           
            985                 990                 995                   

ctg tgg ccc  aag acc cac aca ttg  tgg agc aat gga gtg  ctg gaa        3137
Leu Trp Pro  Lys Thr His Thr Leu  Trp Ser Asn Gly Val  Leu Glu            
        1000                 1005                 1010                    

agc cag atg  ctc att cca aaa tca  tat gcg ggc cct ttt  tca cag        3182
Ser Gln Met  Leu Ile Pro Lys Ser  Tyr Ala Gly Pro Phe  Ser Gln            
        1015                 1020                 1025                    

cac aat tac  cgc cag ggc tat gcc  acg caa acc gtg ggc  cca tgg        3227
His Asn Tyr  Arg Gln Gly Tyr Ala  Thr Gln Thr Val Gly  Pro Trp            
        1030                 1035                 1040                    

cac tta ggc  aaa tta gag ata gac  ttt gga gaa tgc ccc  gga aca        3272
His Leu Gly  Lys Leu Glu Ile Asp  Phe Gly Glu Cys Pro  Gly Thr            
        1045                 1050                 1055                    

aca gtc gca  att cag gag gat tgt  gac cat aga ggc cca  tct ttg        3317
Thr Val Ala  Ile Gln Glu Asp Cys  Asp His Arg Gly Pro  Ser Leu            
        1060                 1065                 1070                    

agg acc acc  act gca tct gga aaa  cta gtc acg caa tgg  tgc tgc        3362
Arg Thr Thr  Thr Ala Ser Gly Lys  Leu Val Thr Gln Trp  Cys Cys            
        1075                 1080                 1085                    

cgc tcc tgc  acg atg cct ccc tta  agg ttc ttg gga gaa  gat ggg        3407
Arg Ser Cys  Thr Met Pro Pro Leu  Arg Phe Leu Gly Glu  Asp Gly            
        1090                 1095                 1100                    

tgc tgg tat  ggg atg gag att agg  ccc ttg agt gaa aaa  gaa gag        3452
Cys Trp Tyr  Gly Met Glu Ile Arg  Pro Leu Ser Glu Lys  Glu Glu            
        1105                 1110                 1115                    

aac atg gtc  aaa tca cag gta acg  gcc gga cag ggc aca  tca gaa        3497
Asn Met Val  Lys Ser Gln Val Thr  Ala Gly Gln Gly Thr  Ser Glu            
        1120                 1125                 1130                    

act ttt tct  atg ggt ctg ttg tgc  ctg acc ttg ttt gtg  gaa gaa        3542
Thr Phe Ser  Met Gly Leu Leu Cys  Leu Thr Leu Phe Val  Glu Glu            
        1135                 1140                 1145                    

tgc ttg agg  aga aga gtc act agg  aaa cac atg ata ttg  gtt gtg        3587
Cys Leu Arg  Arg Arg Val Thr Arg  Lys His Met Ile Leu  Val Val            
        1150                 1155                 1160                    

gtg atc act  ctt tgt gcc atc atc  cta gga ggc ctc aca  tgg atg        3632
Val Ile Thr  Leu Cys Ala Ile Ile  Leu Gly Gly Leu Thr  Trp Met            
        1165                 1170                 1175                    

gac tta cta  cga gcc ctc atc atg  ttg ggg gac act atg  tct ggt        3677
Asp Leu Leu  Arg Ala Leu Ile Met  Leu Gly Asp Thr Met  Ser Gly            
        1180                 1185                 1190                    

aga ata gga  gga cag atc cac cta  gcc atc atg gca gtg  ttc aag        3722
Arg Ile Gly  Gly Gln Ile His Leu  Ala Ile Met Ala Val  Phe Lys            
        1195                 1200                 1205                    

atg tca cca  gga tac gtg ctg ggt  gtg ttt tta agg aaa  ctc act        3767
Met Ser Pro  Gly Tyr Val Leu Gly  Val Phe Leu Arg Lys  Leu Thr            
        1210                 1215                 1220                    

tca aga gag  aca gca cta atg gta  ata gga atg gcc atg  aca acg        3812
Ser Arg Glu  Thr Ala Leu Met Val  Ile Gly Met Ala Met  Thr Thr            
        1225                 1230                 1235                    

gtg ctt tca  att cca cat gac ctt  atg gaa ctc att gat  gga ata        3857
Val Leu Ser  Ile Pro His Asp Leu  Met Glu Leu Ile Asp  Gly Ile            
        1240                 1245                 1250                    

tca ctg ggg  cta att ttg cta aaa  ata gtg aca cat ttt  gac aac        3902
Ser Leu Gly  Leu Ile Leu Leu Lys  Ile Val Thr His Phe  Asp Asn            
        1255                 1260                 1265                    

acc caa gtg  gga acc tta gcc ctt  tcc ttg acc ttc ata  aga tca        3947
Thr Gln Val  Gly Thr Leu Ala Leu  Ser Leu Thr Phe Ile  Arg Ser            
        1270                 1275                 1280                    

aca atg cca  ttg gtc atg gct tgg  agg acc att atg gct  gtg ttg        3992
Thr Met Pro  Leu Val Met Ala Trp  Arg Thr Ile Met Ala  Val Leu            
        1285                 1290                 1295                    

ttt gtg gtc  aca ctc att cct ttg  tgc agg aca agc tgt  ctt caa        4037
Phe Val Val  Thr Leu Ile Pro Leu  Cys Arg Thr Ser Cys  Leu Gln            
        1300                 1305                 1310                    

aaa cag tct  cat tgg gta gaa ata  aca gca ctc atc cta  gga gcc        4082
Lys Gln Ser  His Trp Val Glu Ile  Thr Ala Leu Ile Leu  Gly Ala            
        1315                 1320                 1325                    

caa gct ctg  cca gtg tac cta atg  act ctt atg aaa gga  gcc tca        4127
Gln Ala Leu  Pro Val Tyr Leu Met  Thr Leu Met Lys Gly  Ala Ser            
        1330                 1335                 1340                    

aga aga tct  tgg cct ctt aac gag  ggc ata atg gct gtg  ggt ttg        4172
Arg Arg Ser  Trp Pro Leu Asn Glu  Gly Ile Met Ala Val  Gly Leu            
        1345                 1350                 1355                    

gtt agt ctc  tta gga agc gct ctt  tta aag aat gat gtc  cct tta        4217
Val Ser Leu  Leu Gly Ser Ala Leu  Leu Lys Asn Asp Val  Pro Leu            
        1360                 1365                 1370                    

gct ggc cca  atg gtg gca gga ggc  tta ctt ctg gcg gct  tac gtg        4262
Ala Gly Pro  Met Val Ala Gly Gly  Leu Leu Leu Ala Ala  Tyr Val            
        1375                 1380                 1385                    

atg agt ggt  agc tca gca gat ctg  tca cta gag aag gcc  gcc aat        4307
Met Ser Gly  Ser Ser Ala Asp Leu  Ser Leu Glu Lys Ala  Ala Asn            
        1390                 1395                 1400                    

gtg cag tgg  gat gaa atg gca gac  ata aca ggc tca agc  cca atc        4352
Val Gln Trp  Asp Glu Met Ala Asp  Ile Thr Gly Ser Ser  Pro Ile            
        1405                 1410                 1415                    

ata gaa gtg  aag cag gat gaa gat  ggc tct ttc tcc ata  cgg gac        4397
Ile Glu Val  Lys Gln Asp Glu Asp  Gly Ser Phe Ser Ile  Arg Asp            
        1420                 1425                 1430                    

gtc gag gaa  acc aat atg ata acc  ctt ttg gtg aaa ctg  gca ctg        4442
Val Glu Glu  Thr Asn Met Ile Thr  Leu Leu Val Lys Leu  Ala Leu            
        1435                 1440                 1445                    

ata aca gtg  tca ggt ctc tac ccc  ttg gca att cca gtc  aca atg        4487
Ile Thr Val  Ser Gly Leu Tyr Pro  Leu Ala Ile Pro Val  Thr Met            
        1450                 1455                 1460                    

acc tta tgg  tac atg tgg caa gtg  aaa aca caa aga tca  gga gcc        4532
Thr Leu Trp  Tyr Met Trp Gln Val  Lys Thr Gln Arg Ser  Gly Ala            
        1465                 1470                 1475                    

ctg tgg gac  gtc ccc tca ccc gct  gcc act caa aaa gcc  gca ctg        4577
Leu Trp Asp  Val Pro Ser Pro Ala  Ala Thr Gln Lys Ala  Ala Leu            
        1480                 1485                 1490                    

tct gaa gga  gtg tac agg atc atg  caa aga ggg tta ttt  ggg aaa        4622
Ser Glu Gly  Val Tyr Arg Ile Met  Gln Arg Gly Leu Phe  Gly Lys            
        1495                 1500                 1505                    

act cag gtt  gga gta ggg ata cac  atg gaa ggt gta ttt  cac aca        4667
Thr Gln Val  Gly Val Gly Ile His  Met Glu Gly Val Phe  His Thr            
        1510                 1515                 1520                    

atg tgg cat  gta aca aga gga tca  gtg atc tgc cat gag  act ggg        4712
Met Trp His  Val Thr Arg Gly Ser  Val Ile Cys His Glu  Thr Gly            
        1525                 1530                 1535                    

aga ttg gag  cca tct tgg gct gac  gtc agg aat gac atg  ata tca        4757
Arg Leu Glu  Pro Ser Trp Ala Asp  Val Arg Asn Asp Met  Ile Ser            
        1540                 1545                 1550                    

tac ggt ggg  gga tgg aga ctt gga  gac aaa tgg gac aaa  gaa gaa        4802
Tyr Gly Gly  Gly Trp Arg Leu Gly  Asp Lys Trp Asp Lys  Glu Glu            
        1555                 1560                 1565                    

gat gtt cag  gtc ctc gcc ata gaa  cca gga aaa aat cct  aaa cat        4847
Asp Val Gln  Val Leu Ala Ile Glu  Pro Gly Lys Asn Pro  Lys His            
        1570                 1575                 1580                    

gtc caa acg  aaa ccc ggc ctt ttc  aag acc cta act gga  gaa att        4892
Val Gln Thr  Lys Pro Gly Leu Phe  Lys Thr Leu Thr Gly  Glu Ile            
        1585                 1590                 1595                    

gga gca gta  aca tta gat ttc aaa  ccc gga acg tct ggt  tct ccc        4937
Gly Ala Val  Thr Leu Asp Phe Lys  Pro Gly Thr Ser Gly  Ser Pro            
        1600                 1605                 1610                    

atc atc aac  agg aaa gga aaa gtc  atc gga ctc tat gga  aat gga        4982
Ile Ile Asn  Arg Lys Gly Lys Val  Ile Gly Leu Tyr Gly  Asn Gly            
        1615                 1620                 1625                    

gta gtt acc  aaa tca ggt gat tac  gtc agt gcc ata acg  caa gcc        5027
Val Val Thr  Lys Ser Gly Asp Tyr  Val Ser Ala Ile Thr  Gln Ala            
        1630                 1635                 1640                    

gaa aga att  gga gag cca gat tat  gaa gtg gat gag gac  att ttt        5072
Glu Arg Ile  Gly Glu Pro Asp Tyr  Glu Val Asp Glu Asp  Ile Phe            
        1645                 1650                 1655                    

cga aag aaa  aga tta act ata atg  gac tta cac ccc gga  gct gga        5117
Arg Lys Lys  Arg Leu Thr Ile Met  Asp Leu His Pro Gly  Ala Gly            
        1660                 1665                 1670                    

aag aca aaa  aga att ctt cca tca  ata gtg aga gaa gcc  tta aaa        5162
Lys Thr Lys  Arg Ile Leu Pro Ser  Ile Val Arg Glu Ala  Leu Lys            
        1675                 1680                 1685                    

agg agg ctg  cga acc ttg att ttg  gct ccc acg aga gtg  gtg gcg        5207
Arg Arg Leu  Arg Thr Leu Ile Leu  Ala Pro Thr Arg Val  Val Ala            
        1690                 1695                 1700                    

gcc gag atg  gaa gag gcc cta cgt  gga ctg cca atc cgt  tat cag        5252
Ala Glu Met  Glu Glu Ala Leu Arg  Gly Leu Pro Ile Arg  Tyr Gln            
        1705                 1710                 1715                    

acc cca gct  gtg aaa tca gaa cac  aca gga aga gag att  gta gac        5297
Thr Pro Ala  Val Lys Ser Glu His  Thr Gly Arg Glu Ile  Val Asp            
        1720                 1725                 1730                    

ctc atg tgt  cat gca acc ttc aca  aca aga ctt ttg tca  tca acc        5342
Leu Met Cys  His Ala Thr Phe Thr  Thr Arg Leu Leu Ser  Ser Thr            
        1735                 1740                 1745                    

aga gtt cca  aat tac aac ctc ata  gtg atg gat gaa gca  cat ttc        5387
Arg Val Pro  Asn Tyr Asn Leu Ile  Val Met Asp Glu Ala  His Phe            
        1750                 1755                 1760                    

acc gat cct  tct agt gtc gcg gct  aga gga tac atc tcg  acc agg        5432
Thr Asp Pro  Ser Ser Val Ala Ala  Arg Gly Tyr Ile Ser  Thr Arg            
        1765                 1770                 1775                    

gtg gaa atg  gga gag gca gca gcc  atc ttc atg acc gca  acc cct        5477
Val Glu Met  Gly Glu Ala Ala Ala  Ile Phe Met Thr Ala  Thr Pro            
        1780                 1785                 1790                    

ccc gga gcg  aca gat ccc ttt ccc  cag agc aac agc cca  ata gaa        5522
Pro Gly Ala  Thr Asp Pro Phe Pro  Gln Ser Asn Ser Pro  Ile Glu            
        1795                 1800                 1805                    

gac atc gag  agg gaa att ccg gaa  agg tca tgg aac aca  ggg ttc        5567
Asp Ile Glu  Arg Glu Ile Pro Glu  Arg Ser Trp Asn Thr  Gly Phe            
        1810                 1815                 1820                    

gac tgg ata  aca gac tac caa ggg  aaa act gtg tgg ttt  gtt ccc        5612
Asp Trp Ile  Thr Asp Tyr Gln Gly  Lys Thr Val Trp Phe  Val Pro            
        1825                 1830                 1835                    

agc ata aaa  gct gga aat gac att  gca aat tgt ttg aga  aag tcg        5657
Ser Ile Lys  Ala Gly Asn Asp Ile  Ala Asn Cys Leu Arg  Lys Ser            
        1840                 1845                 1850                    

gga aag aaa  gtt atc cag ttg agt  agg aaa acc ttt gat  aca gag        5702
Gly Lys Lys  Val Ile Gln Leu Ser  Arg Lys Thr Phe Asp  Thr Glu            
        1855                 1860                 1865                    

tat cca aaa  acg aaa ctc acg gac  tgg gat ttt gtg gtc  act aca        5747
Tyr Pro Lys  Thr Lys Leu Thr Asp  Trp Asp Phe Val Val  Thr Thr            
        1870                 1875                 1880                    

gac ata tct  gaa atg ggg gcc aat  ttt aga gct ggg aga  gtg ata        5792
Asp Ile Ser  Glu Met Gly Ala Asn  Phe Arg Ala Gly Arg  Val Ile            
        1885                 1890                 1895                    

gac cct agg  aga tgc ctc aag cca  gtt atc cta aca gat  ggg cca        5837
Asp Pro Arg  Arg Cys Leu Lys Pro  Val Ile Leu Thr Asp  Gly Pro            
        1900                 1905                 1910                    

gag aga gtc  att tta gca ggt cct  att cca gtg act cca  gca agc        5882
Glu Arg Val  Ile Leu Ala Gly Pro  Ile Pro Val Thr Pro  Ala Ser            
        1915                 1920                 1925                    

gct gct cag  aga aga ggg cga ata  gga agg aac cca gca  caa gaa        5927
Ala Ala Gln  Arg Arg Gly Arg Ile  Gly Arg Asn Pro Ala  Gln Glu            
        1930                 1935                 1940                    

gac gac caa  tac gtt ttc tcc gga  gac cca cta aaa aat  gat gaa        5972
Asp Asp Gln  Tyr Val Phe Ser Gly  Asp Pro Leu Lys Asn  Asp Glu            
        1945                 1950                 1955                    

gat cat gcc  cac tgg aca gaa gca  aag atg ctg ctt gac  aat atc        6017
Asp His Ala  His Trp Thr Glu Ala  Lys Met Leu Leu Asp  Asn Ile            
        1960                 1965                 1970                    

tac acc cca  gaa ggg atc att cca  aca ttg ttt ggt ccg  gaa agg        6062
Tyr Thr Pro  Glu Gly Ile Ile Pro  Thr Leu Phe Gly Pro  Glu Arg            
        1975                 1980                 1985                    

gaa aaa acc  caa gcc att gat gga  gag ttt cgc ctc aga  ggg gaa        6107
Glu Lys Thr  Gln Ala Ile Asp Gly  Glu Phe Arg Leu Arg  Gly Glu            
        1990                 1995                 2000                    

caa agg aag  act ttt gtg gaa tta  atg agg aga gga gac  ctt ccg        6152
Gln Arg Lys  Thr Phe Val Glu Leu  Met Arg Arg Gly Asp  Leu Pro            
        2005                 2010                 2015                    

gtg tgg ctg  agc tat aag gta gct  tct gct ggc att tct  tac aaa        6197
Val Trp Leu  Ser Tyr Lys Val Ala  Ser Ala Gly Ile Ser  Tyr Lys            
        2020                 2025                 2030                    

gat cgg gaa  tgg tgc ttc aca ggg  gaa agg aat aac caa  att tta        6242
Asp Arg Glu  Trp Cys Phe Thr Gly  Glu Arg Asn Asn Gln  Ile Leu            
        2035                 2040                 2045                    

gaa gaa aac  atg gag gtt gaa att  tgg act aga gag gga  gaa aag        6287
Glu Glu Asn  Met Glu Val Glu Ile  Trp Thr Arg Glu Gly  Glu Lys            
        2050                 2055                 2060                    

aaa aag cta  agg cca aga tgg tta  gat gca cgt gta tac  gct gac        6332
Lys Lys Leu  Arg Pro Arg Trp Leu  Asp Ala Arg Val Tyr  Ala Asp            
        2065                 2070                 2075                    

ccc atg gct  ttg aag gat ttt aag  gag ttt gct agt gga  agg aag        6377
Pro Met Ala  Leu Lys Asp Phe Lys  Glu Phe Ala Ser Gly  Arg Lys            
        2080                 2085                 2090                    

agc ata act  ctc gac atc cta aca  gag att gcc agt ttg  cca act        6422
Ser Ile Thr  Leu Asp Ile Leu Thr  Glu Ile Ala Ser Leu  Pro Thr            
        2095                 2100                 2105                    

tac ctt tcc  tct agg gcc aag ctc  gcc ctt gat aac ata  gtc atg        6467
Tyr Leu Ser  Ser Arg Ala Lys Leu  Ala Leu Asp Asn Ile  Val Met            
        2110                 2115                 2120                    

ctc cac aca  aca gaa aga gga ggg  agg gcc tac caa cac  gcc ctg        6512
Leu His Thr  Thr Glu Arg Gly Gly  Arg Ala Tyr Gln His  Ala Leu            
        2125                 2130                 2135                    

aac gaa ctc  ccg gag tca ctg gaa  aca ctt atg ctt gta  gct tta        6557
Asn Glu Leu  Pro Glu Ser Leu Glu  Thr Leu Met Leu Val  Ala Leu            
        2140                 2145                 2150                    

cta ggt gct  atg aca gca ggt atc  ttc ctg ttt ttc atg  caa ggg        6602
Leu Gly Ala  Met Thr Ala Gly Ile  Phe Leu Phe Phe Met  Gln Gly            
        2155                 2160                 2165                    

aaa gga ata  ggg aaa ttg tca atg  ggt ttg ata acc att  gcg gtg        6647
Lys Gly Ile  Gly Lys Leu Ser Met  Gly Leu Ile Thr Ile  Ala Val            
        2170                 2175                 2180                    

gct agt ggc  ttg ctc tgg gta gca  gaa att caa ccc cag  tgg ata        6692
Ala Ser Gly  Leu Leu Trp Val Ala  Glu Ile Gln Pro Gln  Trp Ile            
        2185                 2190                 2195                    

gcg gcc tca  atc ata cta gag ttt  ttt ctc atg gta ctg  ttg ata        6737
Ala Ala Ser  Ile Ile Leu Glu Phe  Phe Leu Met Val Leu  Leu Ile            
        2200                 2205                 2210                    

ccg gaa cca  gaa aaa caa agg acc  cca caa gac aat caa  ttg atc        6782
Pro Glu Pro  Glu Lys Gln Arg Thr  Pro Gln Asp Asn Gln  Leu Ile            
        2215                 2220                 2225                    

tac gtc ata  ttg acc att ctc acc  att att ggt ctc ata  gca gcc        6827
Tyr Val Ile  Leu Thr Ile Leu Thr  Ile Ile Gly Leu Ile  Ala Ala            
        2230                 2235                 2240                    

aac gag atg  ggg ctg att gaa aaa  aca aaa acg gat ttt  ggg ttt        6872
Asn Glu Met  Gly Leu Ile Glu Lys  Thr Lys Thr Asp Phe  Gly Phe            
        2245                 2250                 2255                    

tac cag gta  aaa aca gaa acc acc  atc ctc gat gtg gac  ttg aga        6917
Tyr Gln Val  Lys Thr Glu Thr Thr  Ile Leu Asp Val Asp  Leu Arg            
        2260                 2265                 2270                    

cca gct tca  gca tgg acg ctc tat  gca gta gcc acc aca  att ctg        6962
Pro Ala Ser  Ala Trp Thr Leu Tyr  Ala Val Ala Thr Thr  Ile Leu            
        2275                 2280                 2285                    

act ccc atg  ctg aga cac acc ata  gaa aac acg tcg gcc  aac cta        7007
Thr Pro Met  Leu Arg His Thr Ile  Glu Asn Thr Ser Ala  Asn Leu            
        2290                 2295                 2300                    

tct cta gca  gcc att gcc aac cag  gcg gcc gtc cta atg  ggg ctt        7052
Ser Leu Ala  Ala Ile Ala Asn Gln  Ala Ala Val Leu Met  Gly Leu            
        2305                 2310                 2315                    

gga aaa gga  tgg ccg ctc cac aga  atg gac ctc ggt gtg  ccg ctg        7097
Gly Lys Gly  Trp Pro Leu His Arg  Met Asp Leu Gly Val  Pro Leu            
        2320                 2325                 2330                    

tta gca atg  gga tgc tat tct caa  gtg aac cca aca act  ttg aca        7142
Leu Ala Met  Gly Cys Tyr Ser Gln  Val Asn Pro Thr Thr  Leu Thr            
        2335                 2340                 2345                    

gca tcc tta  gtc atg ctt tta gtc  cat tat gca ata ata  ggt cca        7187
Ala Ser Leu  Val Met Leu Leu Val  His Tyr Ala Ile Ile  Gly Pro            
        2350                 2355                 2360                    

gga ttg cag  gca aaa gcc aca aga  gag gcc cag aaa agg  aca gct        7232
Gly Leu Gln  Ala Lys Ala Thr Arg  Glu Ala Gln Lys Arg  Thr Ala            
        2365                 2370                 2375                    

gct ggg atc  atg aaa aac ccc acg  gtg gac ggg ata aca  gta ata        7277
Ala Gly Ile  Met Lys Asn Pro Thr  Val Asp Gly Ile Thr  Val Ile            
        2380                 2385                 2390                    

gat cta gaa  cca ata tcc tat gac  cca aaa ttt gaa aag  caa tta        7322
Asp Leu Glu  Pro Ile Ser Tyr Asp  Pro Lys Phe Glu Lys  Gln Leu            
        2395                 2400                 2405                    

ggg cag gtc  atg cta ctc gtc ttg  tgt gct gga caa cta  ctc ttg        7367
Gly Gln Val  Met Leu Leu Val Leu  Cys Ala Gly Gln Leu  Leu Leu            
        2410                 2415                 2420                    

atg aga aca  aca tgg gct ttc tgt  gaa gtc ttg act ttg  gcc aca        7412
Met Arg Thr  Thr Trp Ala Phe Cys  Glu Val Leu Thr Leu  Ala Thr            
        2425                 2430                 2435                    

gga cca atc  ttg acc ttg tgg gag  ggc aac ccg gga agg  ttt tgg        7457
Gly Pro Ile  Leu Thr Leu Trp Glu  Gly Asn Pro Gly Arg  Phe Trp            
        2440                 2445                 2450                    

aac acg acc  ata gcc gta tcc acc  gcc aac att ttc agg  gga agt        7502
Asn Thr Thr  Ile Ala Val Ser Thr  Ala Asn Ile Phe Arg  Gly Ser            
        2455                 2460                 2465                    

tac ctg gcg  gga gct gga ctg gct  ttt tca ctc ata aag  aat gca        7547
Tyr Leu Ala  Gly Ala Gly Leu Ala  Phe Ser Leu Ile Lys  Asn Ala            
        2470                 2475                 2480                    

caa acc cct  agg agg gga act ggg  acc aca gga gag aca  ctg gga        7592
Gln Thr Pro  Arg Arg Gly Thr Gly  Thr Thr Gly Glu Thr  Leu Gly            
        2485                 2490                 2495                    

gag aag tgg  aag aga cag cta aac  tca tta gac aga aaa  gag ttt        7637
Glu Lys Trp  Lys Arg Gln Leu Asn  Ser Leu Asp Arg Lys  Glu Phe            
        2500                 2505                 2510                    

gaa gag tat  aaa aga agt gga ata  cta gaa gtg gac agg  act gaa        7682
Glu Glu Tyr  Lys Arg Ser Gly Ile  Leu Glu Val Asp Arg  Thr Glu            
        2515                 2520                 2525                    

gcc aag tct  gcc ctg aaa gat ggg  tct aaa atc aag cat  gca gta        7727
Ala Lys Ser  Ala Leu Lys Asp Gly  Ser Lys Ile Lys His  Ala Val            
        2530                 2535                 2540                    

tct aga ggg  tcc agt aag att aga  tgg att gtt gag aga  ggg atg        7772
Ser Arg Gly  Ser Ser Lys Ile Arg  Trp Ile Val Glu Arg  Gly Met            
        2545                 2550                 2555                    

gta aag cca  aaa ggg aaa gtt gta  gat ctt ggc tgt ggg  aga gga        7817
Val Lys Pro  Lys Gly Lys Val Val  Asp Leu Gly Cys Gly  Arg Gly            
        2560                 2565                 2570                    

gga tgg tct  tat tac atg gcg acg  ctc aag aac gtg act  gaa gtg        7862
Gly Trp Ser  Tyr Tyr Met Ala Thr  Leu Lys Asn Val Thr  Glu Val            
        2575                 2580                 2585                    

aaa ggg tat  aca aaa gga ggt cca  gga cat gaa gaa ccg  att ccc        7907
Lys Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu Glu Pro  Ile Pro            
        2590                 2595                 2600                    

atg gct act  tat ggc tgg aat ttg  gtc aaa ctc cat tca  ggg gtt        7952
Met Ala Thr  Tyr Gly Trp Asn Leu  Val Lys Leu His Ser  Gly Val            
        2605                 2610                 2615                    

gac gtg ttc  tac aaa ccc aca gag  caa gtg gac acc ctg  ctc tgt        7997
Asp Val Phe  Tyr Lys Pro Thr Glu  Gln Val Asp Thr Leu  Leu Cys            
        2620                 2625                 2630                    

gat att ggg  gag tca tct tct aat  cca aca ata gag gaa  gga aga        8042
Asp Ile Gly  Glu Ser Ser Ser Asn  Pro Thr Ile Glu Glu  Gly Arg            
        2635                 2640                 2645                    

aca tta aga  gtt ttg aag atg gtg  gag cca tgg ctc tct  tca aaa        8087
Thr Leu Arg  Val Leu Lys Met Val  Glu Pro Trp Leu Ser  Ser Lys            
        2650                 2655                 2660                    

cct gaa ttc  tgc atc aaa gtc ctt  aac ccc tac atg cca  aca gtc        8132
Pro Glu Phe  Cys Ile Lys Val Leu  Asn Pro Tyr Met Pro  Thr Val            
        2665                 2670                 2675                    

ata gaa gag  ctg gag aaa ctg cag  aga aaa cat ggt ggg  aac ctt        8177
Ile Glu Glu  Leu Glu Lys Leu Gln  Arg Lys His Gly Gly  Asn Leu            
        2680                 2685                 2690                    

gtc aga tgc  ccg ctg tcc agg aac  tcc acc cat gag atg  tat tgg        8222
Val Arg Cys  Pro Leu Ser Arg Asn  Ser Thr His Glu Met  Tyr Trp            
        2695                 2700                 2705                    

gtg tca gga  gcg tcg gga aac att  gtg agc tct gtg aac  aca aca        8267
Val Ser Gly  Ala Ser Gly Asn Ile  Val Ser Ser Val Asn  Thr Thr            
        2710                 2715                 2720                    

tca aag atg  ttg ttg aac agg ttc  aca aca agg cat agg  aaa ccc        8312
Ser Lys Met  Leu Leu Asn Arg Phe  Thr Thr Arg His Arg  Lys Pro            
        2725                 2730                 2735                    

act tat gag  aag gac gta gat ctt  ggg gca gga acg aga  agt gtc        8357
Thr Tyr Glu  Lys Asp Val Asp Leu  Gly Ala Gly Thr Arg  Ser Val            
        2740                 2745                 2750                    

tcc act gaa  aca gaa aaa cca gac  atg aca att att ggg  aga agg        8402
Ser Thr Glu  Thr Glu Lys Pro Asp  Met Thr Ile Ile Gly  Arg Arg            
        2755                 2760                 2765                    

ctt cag cga  ttg caa gag gag cac  aaa gaa acc tgg cat  tat gat        8447
Leu Gln Arg  Leu Gln Glu Glu His  Lys Glu Thr Trp His  Tyr Asp            
        2770                 2775                 2780                    

cag gaa aac  cca tac aga acc tgg  gcg tat cat gga agc  tat gaa        8492
Gln Glu Asn  Pro Tyr Arg Thr Trp  Ala Tyr His Gly Ser  Tyr Glu            
        2785                 2790                 2795                    

gct cct tcg  aca ggc tct gca tcc  tcc atg gtg aac ggg  gta gta        8537
Ala Pro Ser  Thr Gly Ser Ala Ser  Ser Met Val Asn Gly  Val Val            
        2800                 2805                 2810                    

aaa ctg cta  aca aaa cct tgg gat  gtg gtt cca atg gtg  acc cag        8582
Lys Leu Leu  Thr Lys Pro Trp Asp  Val Val Pro Met Val  Thr Gln            
        2815                 2820                 2825                    

tta gcc atg  aca gac aca acc cct  ttt ggg caa caa aga  gtg ttc        8627
Leu Ala Met  Thr Asp Thr Thr Pro  Phe Gly Gln Gln Arg  Val Phe            
        2830                 2835                 2840                    

aaa gag aag  gtg gat acc aga aca  cca caa cca aaa ccc  ggt aca        8672
Lys Glu Lys  Val Asp Thr Arg Thr  Pro Gln Pro Lys Pro  Gly Thr            
        2845                 2850                 2855                    

cga atg gtt  atg acc acg aca gcc  aat tgg ctg tgg gcc  ctc ctt        8717
Arg Met Val  Met Thr Thr Thr Ala  Asn Trp Leu Trp Ala  Leu Leu            
        2860                 2865                 2870                    

ggg aag aag  aaa aat ccc aga ctg  tgc aca agg gaa gag  ttc atc        8762
Gly Lys Lys  Lys Asn Pro Arg Leu  Cys Thr Arg Glu Glu  Phe Ile            
        2875                 2880                 2885                    

tca aaa gtt  aga tca aac gca gcc  ata ggc gca gtc ttt  cag gaa        8807
Ser Lys Val  Arg Ser Asn Ala Ala  Ile Gly Ala Val Phe  Gln Glu            
        2890                 2895                 2900                    

gaa cag gga  tgg aca tca gcc agt  gaa gct gtg aat gac  agc cgg        8852
Glu Gln Gly  Trp Thr Ser Ala Ser  Glu Ala Val Asn Asp  Ser Arg            
        2905                 2910                 2915                    

ttt tgg gaa  ctg gtt gac aaa gaa  agg gcc cta cac cag  gaa ggg        8897
Phe Trp Glu  Leu Val Asp Lys Glu  Arg Ala Leu His Gln  Glu Gly            
        2920                 2925                 2930                    

aaa tgt gaa  tcg tgt gtc tac aac  atg atg gga aaa cgt  gag aaa        8942
Lys Cys Glu  Ser Cys Val Tyr Asn  Met Met Gly Lys Arg  Glu Lys            
        2935                 2940                 2945                    

aag tta gga  gag ttt ggc aga gcc  aag gga agc cga gca  atc tgg        8987
Lys Leu Gly  Glu Phe Gly Arg Ala  Lys Gly Ser Arg Ala  Ile Trp            
        2950                 2955                 2960                    

tac atg tgg  ctg gga gcg cgg ttt  ctg gaa ttt gaa gcc  ctg ggt        9032
Tyr Met Trp  Leu Gly Ala Arg Phe  Leu Glu Phe Glu Ala  Leu Gly            
        2965                 2970                 2975                    

ttt ttg aat  gaa gat cac tgg ttt  ggc aga gaa aat tca  tgg agt        9077
Phe Leu Asn  Glu Asp His Trp Phe  Gly Arg Glu Asn Ser  Trp Ser            
        2980                 2985                 2990                    

gga gtg gaa  ggg gaa ggt ctg cac  aga ttg gga tat atc  ctg gag        9122
Gly Val Glu  Gly Glu Gly Leu His  Arg Leu Gly Tyr Ile  Leu Glu            
        2995                 3000                 3005                    

gag ata gac  aag aag gat gga gac  cta atg tat gct gat  gac aca        9167
Glu Ile Asp  Lys Lys Asp Gly Asp  Leu Met Tyr Ala Asp  Asp Thr            
        3010                 3015                 3020                    

gca ggc tgg  gac aca aga atc act  gag gat gac ctt caa  aat gaa        9212
Ala Gly Trp  Asp Thr Arg Ile Thr  Glu Asp Asp Leu Gln  Asn Glu            
        3025                 3030                 3035                    

gaa ctg atc  acg gaa cag atg gcc  ccc cac cac aag atc  cta gcc        9257
Glu Leu Ile  Thr Glu Gln Met Ala  Pro His His Lys Ile  Leu Ala            
        3040                 3045                 3050                    

aaa gcc att  ttc aaa cta acc tat  caa aac aaa gtg gtg  aaa gtc        9302
Lys Ala Ile  Phe Lys Leu Thr Tyr  Gln Asn Lys Val Val  Lys Val            
        3055                 3060                 3065                    

ctc aga ccc  aca ccg aga gga gcg  gtg atg gat atc ata  tcc agg        9347
Leu Arg Pro  Thr Pro Arg Gly Ala  Val Met Asp Ile Ile  Ser Arg            
        3070                 3075                 3080                    

aaa gac caa  aga ggt agt gga caa  gtt gga aca tat ggt  ttg aac        9392
Lys Asp Gln  Arg Gly Ser Gly Gln  Val Gly Thr Tyr Gly  Leu Asn            
        3085                 3090                 3095                    

aca ttc acc  aac atg gaa gtt caa  ctc atc cgc caa atg  gaa gct        9437
Thr Phe Thr  Asn Met Glu Val Gln  Leu Ile Arg Gln Met  Glu Ala            
        3100                 3105                 3110                    

gaa gga gtc  atc aca caa gat gac  atg cag aac cca aaa  ggg ttg        9482
Glu Gly Val  Ile Thr Gln Asp Asp  Met Gln Asn Pro Lys  Gly Leu            
        3115                 3120                 3125                    

aaa gaa aga  gtt gag aaa tgg ctg  aaa gag tgt ggt gtc  gac agg        9527
Lys Glu Arg  Val Glu Lys Trp Leu  Lys Glu Cys Gly Val  Asp Arg            
        3130                 3135                 3140                    

tta aag agg  atg gca atc agt gga  gac gat tgc gtg gtg  aag ccc        9572
Leu Lys Arg  Met Ala Ile Ser Gly  Asp Asp Cys Val Val  Lys Pro            
        3145                 3150                 3155                    

ctg gat gag  agg ttt ggc act tcc  ctc ctc ttc ttg aac  gac atg        9617
Leu Asp Glu  Arg Phe Gly Thr Ser  Leu Leu Phe Leu Asn  Asp Met            
        3160                 3165                 3170                    

gga aag gtg  agg aaa gac att ccg  cag tgg gaa cca tct  aag gga        9662
Gly Lys Val  Arg Lys Asp Ile Pro  Gln Trp Glu Pro Ser  Lys Gly            
        3175                 3180                 3185                    

tgg aaa aac  tgg caa gag gtt cct  ttt tgc tcc cac cac  ttt cac        9707
Trp Lys Asn  Trp Gln Glu Val Pro  Phe Cys Ser His His  Phe His            
        3190                 3195                 3200                    

aag atc ttc  atg aag gat ggc cgc  tca cta gtt gtt cca  tgt aga        9752
Lys Ile Phe  Met Lys Asp Gly Arg  Ser Leu Val Val Pro  Cys Arg            
        3205                 3210                 3215                    

aac cag gat  gaa ctg ata ggg aga  gcc aga atc tcg cag  ggg gct        9797
Asn Gln Asp  Glu Leu Ile Gly Arg  Ala Arg Ile Ser Gln  Gly Ala            
        3220                 3225                 3230                    

gga tgg agc  tta aga gaa aca gcc  tgc ctg ggc aaa gct  tac gcc        9842
Gly Trp Ser  Leu Arg Glu Thr Ala  Cys Leu Gly Lys Ala  Tyr Ala            
        3235                 3240                 3245                    

cag atg tgg  tcg ctc atg tac ttc  cac aga agg gat ctg  cgt tta        9887
Gln Met Trp  Ser Leu Met Tyr Phe  His Arg Arg Asp Leu  Arg Leu            
        3250                 3255                 3260                    

gcc tcc atg  gcc ata tgc tca gca  gtt cca acg gaa tgg  ttt cca        9932
Ala Ser Met  Ala Ile Cys Ser Ala  Val Pro Thr Glu Trp  Phe Pro            
        3265                 3270                 3275                    

aca agc aga  aca aca tgg tca atc  cac gct cat cat cag  tgg atg        9977
Thr Ser Arg  Thr Thr Trp Ser Ile  His Ala His His Gln  Trp Met            
        3280                 3285                 3290                    

acc act gaa  gat atg ctc aaa gtg  tgg aac aga gtg tgg  ata gaa       10022
Thr Thr Glu  Asp Met Leu Lys Val  Trp Asn Arg Val Trp  Ile Glu            
        3295                 3300                 3305                    

gac aac cct  aat atg act gac aag  act cca gtc cat tcg  tgg gaa       10067
Asp Asn Pro  Asn Met Thr Asp Lys  Thr Pro Val His Ser  Trp Glu            
        3310                 3315                 3320                    

gat ata cct  tac cta ggg aaa aga  gag gat ttg tgg tgt  gga tcc       10112
Asp Ile Pro  Tyr Leu Gly Lys Arg  Glu Asp Leu Trp Cys  Gly Ser            
        3325                 3330                 3335                    

ctg att gga  ctt tct tcc aga gcc  acc tgg gcg aag aac  att cac       10157
Leu Ile Gly  Leu Ser Ser Arg Ala  Thr Trp Ala Lys Asn  Ile His            
        3340                 3345                 3350                    

acg gcc ata  acc cag gtc aga aac  ctg atc gga aaa gag  gaa tac       10202
Thr Ala Ile  Thr Gln Val Arg Asn  Leu Ile Gly Lys Glu  Glu Tyr            
        3355                 3360                 3365                    

gtg gat tac  atg cca gta atg aaa  aga tac agc gct cct  tca gag       10247
Val Asp Tyr  Met Pro Val Met Lys  Arg Tyr Ser Ala Pro  Ser Glu            
        3370                 3375                 3380                    

agt gaa gga  gtt ctg taa ttaccaacaa caaacaccaa aggctattga            10295
Ser Glu Gly  Val Leu                                                      
        3385                                                              

agtcaggcca cttgtgccac ggcttgagca aaccgtgctg cctgtagctc cgccaataat    10355

gggaggcgtg aaatccctag ggaggccatg cgccacggaa gctgtacgcg tggcatattg    10415

gactagcggt tagaggagac ccctcccatc actgacaaaa cgcagcaaaa gggggcccga    10475

agccaggagg aagctgtact cctggtggaa ggactagagg ttagaggaga cccccccaac    10535

acaaaaacag catattgacg ctgggaaaga ccagagatcc tgctgtctct gcaacatcaa    10595

tccaggcaca gagcgaagca agatggattg gtgttgttga tccaacaggt tct           10648


<210>  10
<211>  3387
<212>  PRT
<213>  Dengue virus type 4

<400>  10

Met Asn Gln Arg Lys Lys Val Val Arg Pro Pro Phe Asn Met Leu Lys 
1               5                   10                  15      


Arg Glu Arg Asn Arg Val Ser Thr Pro Gln Gly Leu Val Lys Arg Phe 
            20                  25                  30          


Ser Thr Gly Leu Phe Ser Gly Lys Gly Pro Leu Arg Met Val Leu Ala 
        35                  40                  45              


Phe Ile Thr Phe Leu Arg Val Leu Ser Ile Pro Pro Thr Ala Gly Ile 
    50                  55                  60                  


Leu Lys Arg Trp Gly Gln Leu Lys Lys Asn Lys Ala Ile Arg Ile Leu 
65                  70                  75                  80  


Ile Gly Phe Arg Lys Glu Ile Gly Arg Met Leu Asn Ile Leu Asn Gly 
                85                  90                  95      


Arg Lys Arg Ser Thr Ile Thr Leu Leu Cys Leu Ile Pro Thr Val Met 
            100                 105                 110         


Ala Phe His Leu Ser Thr Arg Asp Gly Glu Pro Leu Met Ile Val Ala 
        115                 120                 125             


Lys His Glu Arg Gly Arg Pro Leu Leu Phe Lys Thr Thr Glu Gly Ile 
    130                 135                 140                 


Asn Lys Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Glu Asp 
145                 150                 155                 160 


Thr Val Thr Tyr Lys Cys Pro Leu Leu Val Asn Thr Glu Pro Glu Asp 
                165                 170                 175     


Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Met Tyr Gly Thr 
            180                 185                 190         


Cys Thr Gln Ser Gly Glu Arg Arg Arg Glu Lys Arg Ser Val Ala Leu 
        195                 200                 205             


Thr Pro His Ser Gly Met Gly Leu Glu Thr Arg Ala Glu Thr Trp Met 
    210                 215                 220                 


Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg Val Glu Ser Trp Ile 
225                 230                 235                 240 


Leu Arg Asn Pro Gly Phe Ala Leu Leu Ala Gly Phe Met Ala Tyr Met 
                245                 250                 255     


Ile Gly Gln Thr Gly Ile Gln Arg Thr Val Phe Phe Val Leu Met Met 
            260                 265                 270         


Leu Val Ala Pro Ser Tyr Gly Met Arg Cys Val Gly Val Gly Asn Arg 
        275                 280                 285             


Asp Phe Val Glu Gly Val Ser Gly Gly Ala Trp Val Asp Leu Val Leu 
    290                 295                 300                 


Glu His Gly Gly Cys Val Thr Thr Met Ala Gln Gly Lys Pro Thr Leu 
305                 310                 315                 320 


Asp Phe Glu Leu Thr Lys Thr Thr Ala Lys Glu Val Ala Leu Leu Arg 
                325                 330                 335     


Thr Tyr Cys Ile Glu Ala Ser Ile Ser Asn Ile Thr Thr Ala Thr Arg 
            340                 345                 350         


Cys Pro Thr Gln Gly Glu Pro Tyr Leu Lys Glu Glu Gln Asp Gln Gln 
        355                 360                 365             


Tyr Ile Cys Arg Arg Asp Val Val Asp Arg Gly Trp Gly Asn Gly Cys 
    370                 375                 380                 


Gly Leu Phe Gly Lys Gly Gly Val Val Thr Cys Ala Lys Phe Ser Cys 
385                 390                 395                 400 


Ser Gly Lys Ile Thr Gly Asn Leu Val Gln Ile Glu Asn Leu Glu Tyr 
                405                 410                 415     


Thr Val Val Val Thr Val His Asn Gly Asp Thr His Ala Val Gly Asn 
            420                 425                 430         


Asp Thr Ser Asn His Gly Val Thr Ala Thr Ile Thr Pro Arg Ser Pro 
        435                 440                 445             


Ser Val Glu Val Lys Leu Pro Asp Tyr Gly Glu Leu Thr Leu Asp Cys 
    450                 455                 460                 


Glu Pro Arg Ser Gly Ile Asp Phe Asn Glu Met Ile Leu Met Lys Met 
465                 470                 475                 480 


Lys Lys Lys Thr Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu Pro 
                485                 490                 495     


Leu Pro Trp Thr Ala Gly Ala Asp Thr Ser Glu Val His Trp Asn Tyr 
            500                 505                 510         


Lys Glu Arg Met Val Thr Phe Lys Val Pro His Ala Lys Arg Gln Asp 
        515                 520                 525             


Val Thr Val Leu Gly Ser Gln Glu Gly Ala Met His Ser Ala Leu Ala 
    530                 535                 540                 


Gly Ala Thr Glu Val Asp Ser Gly Asp Gly Asn His Met Phe Ala Gly 
545                 550                 555                 560 


His Leu Lys Cys Lys Val Arg Met Glu Lys Leu Arg Ile Lys Gly Met 
                565                 570                 575     


Ser Tyr Thr Met Cys Ser Gly Lys Phe Ser Ile Asp Lys Glu Met Ala 
            580                 585                 590         


Glu Thr Gln His Gly Thr Thr Val Val Lys Val Lys Tyr Glu Gly Ala 
        595                 600                 605             


Gly Ala Pro Cys Lys Val Pro Ile Glu Ile Arg Asp Val Asn Lys Glu 
    610                 615                 620                 


Lys Val Val Gly Arg Ile Ile Ser Ser Thr Pro Leu Ala Glu Asn Thr 
625                 630                 635                 640 


Asn Ser Ala Thr Asn Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser Tyr 
                645                 650                 655     


Ile Val Ile Gly Val Gly Asn Ser Ala Leu Thr Leu His Trp Phe Arg 
            660                 665                 670         


Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ser Thr Tyr Arg Gly Ala 
        675                 680                 685             


Lys Arg Met Ala Ile Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser Val 
    690                 695                 700                 


Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala Val His Gln Val Phe Gly 
705                 710                 715                 720 


Ser Val Tyr Thr Thr Met Phe Gly Gly Val Ser Trp Met Ile Arg Ile 
                725                 730                 735     


Leu Ile Gly Phe Leu Val Leu Trp Ile Gly Thr Asn Ser Arg Asn Thr 
            740                 745                 750         


Ser Met Ala Met Thr Cys Ile Ala Val Gly Gly Ile Thr Leu Phe Leu 
        755                 760                 765             


Gly Phe Thr Val Gln Ala Asp Met Gly Cys Val Val Ser Trp Ser Gly 
    770                 775                 780                 


Lys Glu Leu Lys Cys Gly Ser Gly Ile Phe Val Val Asp Asn Val His 
785                 790                 795                 800 


Thr Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ala Arg Leu 
                805                 810                 815     


Ala Ser Ala Ile Leu Asn Ala His Lys Asp Gly Val Cys Gly Ile Arg 
            820                 825                 830         


Ser Thr Thr Arg Leu Glu Asn Val Met Trp Lys Gln Ile Thr Asn Glu 
        835                 840                 845             


Leu Asn Tyr Val Leu Trp Glu Gly Gly His Asp Leu Thr Val Val Ala 
    850                 855                 860                 


Gly Asp Val Lys Gly Val Leu Thr Lys Gly Lys Arg Ala Leu Thr Pro 
865                 870                 875                 880 


Pro Val Asn Asp Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys 
                885                 890                 895     


Ile Phe Thr Pro Glu Ala Arg Asn Ser Thr Phe Leu Ile Asp Gly Pro 
            900                 905                 910         


Asp Thr Ser Glu Cys Pro Asn Glu Arg Arg Ala Trp Asn Phe Leu Glu 
        915                 920                 925             


Val Glu Asp Tyr Gly Phe Gly Met Phe Thr Thr Asn Ile Trp Met Lys 
    930                 935                 940                 


Phe Arg Glu Gly Ser Ser Glu Val Cys Asp His Arg Leu Met Ser Ala 
945                 950                 955                 960 


Ala Ile Lys Asp Gln Lys Ala Val His Ala Asp Met Gly Tyr Trp Ile 
                965                 970                 975     


Glu Ser Ser Lys Asn Gln Thr Trp Gln Ile Glu Lys Ala Ser Leu Ile 
            980                 985                 990         


Glu Val Lys Thr Cys Leu Trp Pro  Lys Thr His Thr Leu  Trp Ser Asn 
        995                 1000                 1005             


Gly Val  Leu Glu Ser Gln Met  Leu Ile Pro Lys Ser  Tyr Ala Gly 
    1010                 1015                 1020             


Pro Phe  Ser Gln His Asn Tyr  Arg Gln Gly Tyr Ala  Thr Gln Thr 
    1025                 1030                 1035             


Val Gly  Pro Trp His Leu Gly  Lys Leu Glu Ile Asp  Phe Gly Glu 
    1040                 1045                 1050             


Cys Pro  Gly Thr Thr Val Ala  Ile Gln Glu Asp Cys  Asp His Arg 
    1055                 1060                 1065             


Gly Pro  Ser Leu Arg Thr Thr  Thr Ala Ser Gly Lys  Leu Val Thr 
    1070                 1075                 1080             


Gln Trp  Cys Cys Arg Ser Cys  Thr Met Pro Pro Leu  Arg Phe Leu 
    1085                 1090                 1095             


Gly Glu  Asp Gly Cys Trp Tyr  Gly Met Glu Ile Arg  Pro Leu Ser 
    1100                 1105                 1110             


Glu Lys  Glu Glu Asn Met Val  Lys Ser Gln Val Thr  Ala Gly Gln 
    1115                 1120                 1125             


Gly Thr  Ser Glu Thr Phe Ser  Met Gly Leu Leu Cys  Leu Thr Leu 
    1130                 1135                 1140             


Phe Val  Glu Glu Cys Leu Arg  Arg Arg Val Thr Arg  Lys His Met 
    1145                 1150                 1155             


Ile Leu  Val Val Val Ile Thr  Leu Cys Ala Ile Ile  Leu Gly Gly 
    1160                 1165                 1170             


Leu Thr  Trp Met Asp Leu Leu  Arg Ala Leu Ile Met  Leu Gly Asp 
    1175                 1180                 1185             


Thr Met  Ser Gly Arg Ile Gly  Gly Gln Ile His Leu  Ala Ile Met 
    1190                 1195                 1200             


Ala Val  Phe Lys Met Ser Pro  Gly Tyr Val Leu Gly  Val Phe Leu 
    1205                 1210                 1215             


Arg Lys  Leu Thr Ser Arg Glu  Thr Ala Leu Met Val  Ile Gly Met 
    1220                 1225                 1230             


Ala Met  Thr Thr Val Leu Ser  Ile Pro His Asp Leu  Met Glu Leu 
    1235                 1240                 1245             


Ile Asp  Gly Ile Ser Leu Gly  Leu Ile Leu Leu Lys  Ile Val Thr 
    1250                 1255                 1260             


His Phe  Asp Asn Thr Gln Val  Gly Thr Leu Ala Leu  Ser Leu Thr 
    1265                 1270                 1275             


Phe Ile  Arg Ser Thr Met Pro  Leu Val Met Ala Trp  Arg Thr Ile 
    1280                 1285                 1290             


Met Ala  Val Leu Phe Val Val  Thr Leu Ile Pro Leu  Cys Arg Thr 
    1295                 1300                 1305             


Ser Cys  Leu Gln Lys Gln Ser  His Trp Val Glu Ile  Thr Ala Leu 
    1310                 1315                 1320             


Ile Leu  Gly Ala Gln Ala Leu  Pro Val Tyr Leu Met  Thr Leu Met 
    1325                 1330                 1335             


Lys Gly  Ala Ser Arg Arg Ser  Trp Pro Leu Asn Glu  Gly Ile Met 
    1340                 1345                 1350             


Ala Val  Gly Leu Val Ser Leu  Leu Gly Ser Ala Leu  Leu Lys Asn 
    1355                 1360                 1365             


Asp Val  Pro Leu Ala Gly Pro  Met Val Ala Gly Gly  Leu Leu Leu 
    1370                 1375                 1380             


Ala Ala  Tyr Val Met Ser Gly  Ser Ser Ala Asp Leu  Ser Leu Glu 
    1385                 1390                 1395             


Lys Ala  Ala Asn Val Gln Trp  Asp Glu Met Ala Asp  Ile Thr Gly 
    1400                 1405                 1410             


Ser Ser  Pro Ile Ile Glu Val  Lys Gln Asp Glu Asp  Gly Ser Phe 
    1415                 1420                 1425             


Ser Ile  Arg Asp Val Glu Glu  Thr Asn Met Ile Thr  Leu Leu Val 
    1430                 1435                 1440             


Lys Leu  Ala Leu Ile Thr Val  Ser Gly Leu Tyr Pro  Leu Ala Ile 
    1445                 1450                 1455             


Pro Val  Thr Met Thr Leu Trp  Tyr Met Trp Gln Val  Lys Thr Gln 
    1460                 1465                 1470             


Arg Ser  Gly Ala Leu Trp Asp  Val Pro Ser Pro Ala  Ala Thr Gln 
    1475                 1480                 1485             


Lys Ala  Ala Leu Ser Glu Gly  Val Tyr Arg Ile Met  Gln Arg Gly 
    1490                 1495                 1500             


Leu Phe  Gly Lys Thr Gln Val  Gly Val Gly Ile His  Met Glu Gly 
    1505                 1510                 1515             


Val Phe  His Thr Met Trp His  Val Thr Arg Gly Ser  Val Ile Cys 
    1520                 1525                 1530             


His Glu  Thr Gly Arg Leu Glu  Pro Ser Trp Ala Asp  Val Arg Asn 
    1535                 1540                 1545             


Asp Met  Ile Ser Tyr Gly Gly  Gly Trp Arg Leu Gly  Asp Lys Trp 
    1550                 1555                 1560             


Asp Lys  Glu Glu Asp Val Gln  Val Leu Ala Ile Glu  Pro Gly Lys 
    1565                 1570                 1575             


Asn Pro  Lys His Val Gln Thr  Lys Pro Gly Leu Phe  Lys Thr Leu 
    1580                 1585                 1590             


Thr Gly  Glu Ile Gly Ala Val  Thr Leu Asp Phe Lys  Pro Gly Thr 
    1595                 1600                 1605             


Ser Gly  Ser Pro Ile Ile Asn  Arg Lys Gly Lys Val  Ile Gly Leu 
    1610                 1615                 1620             


Tyr Gly  Asn Gly Val Val Thr  Lys Ser Gly Asp Tyr  Val Ser Ala 
    1625                 1630                 1635             


Ile Thr  Gln Ala Glu Arg Ile  Gly Glu Pro Asp Tyr  Glu Val Asp 
    1640                 1645                 1650             


Glu Asp  Ile Phe Arg Lys Lys  Arg Leu Thr Ile Met  Asp Leu His 
    1655                 1660                 1665             


Pro Gly  Ala Gly Lys Thr Lys  Arg Ile Leu Pro Ser  Ile Val Arg 
    1670                 1675                 1680             


Glu Ala  Leu Lys Arg Arg Leu  Arg Thr Leu Ile Leu  Ala Pro Thr 
    1685                 1690                 1695             


Arg Val  Val Ala Ala Glu Met  Glu Glu Ala Leu Arg  Gly Leu Pro 
    1700                 1705                 1710             


Ile Arg  Tyr Gln Thr Pro Ala  Val Lys Ser Glu His  Thr Gly Arg 
    1715                 1720                 1725             


Glu Ile  Val Asp Leu Met Cys  His Ala Thr Phe Thr  Thr Arg Leu 
    1730                 1735                 1740             


Leu Ser  Ser Thr Arg Val Pro  Asn Tyr Asn Leu Ile  Val Met Asp 
    1745                 1750                 1755             


Glu Ala  His Phe Thr Asp Pro  Ser Ser Val Ala Ala  Arg Gly Tyr 
    1760                 1765                 1770             


Ile Ser  Thr Arg Val Glu Met  Gly Glu Ala Ala Ala  Ile Phe Met 
    1775                 1780                 1785             


Thr Ala  Thr Pro Pro Gly Ala  Thr Asp Pro Phe Pro  Gln Ser Asn 
    1790                 1795                 1800             


Ser Pro  Ile Glu Asp Ile Glu  Arg Glu Ile Pro Glu  Arg Ser Trp 
    1805                 1810                 1815             


Asn Thr  Gly Phe Asp Trp Ile  Thr Asp Tyr Gln Gly  Lys Thr Val 
    1820                 1825                 1830             


Trp Phe  Val Pro Ser Ile Lys  Ala Gly Asn Asp Ile  Ala Asn Cys 
    1835                 1840                 1845             


Leu Arg  Lys Ser Gly Lys Lys  Val Ile Gln Leu Ser  Arg Lys Thr 
    1850                 1855                 1860             


Phe Asp  Thr Glu Tyr Pro Lys  Thr Lys Leu Thr Asp  Trp Asp Phe 
    1865                 1870                 1875             


Val Val  Thr Thr Asp Ile Ser  Glu Met Gly Ala Asn  Phe Arg Ala 
    1880                 1885                 1890             


Gly Arg  Val Ile Asp Pro Arg  Arg Cys Leu Lys Pro  Val Ile Leu 
    1895                 1900                 1905             


Thr Asp  Gly Pro Glu Arg Val  Ile Leu Ala Gly Pro  Ile Pro Val 
    1910                 1915                 1920             


Thr Pro  Ala Ser Ala Ala Gln  Arg Arg Gly Arg Ile  Gly Arg Asn 
    1925                 1930                 1935             


Pro Ala  Gln Glu Asp Asp Gln  Tyr Val Phe Ser Gly  Asp Pro Leu 
    1940                 1945                 1950             


Lys Asn  Asp Glu Asp His Ala  His Trp Thr Glu Ala  Lys Met Leu 
    1955                 1960                 1965             


Leu Asp  Asn Ile Tyr Thr Pro  Glu Gly Ile Ile Pro  Thr Leu Phe 
    1970                 1975                 1980             


Gly Pro  Glu Arg Glu Lys Thr  Gln Ala Ile Asp Gly  Glu Phe Arg 
    1985                 1990                 1995             


Leu Arg  Gly Glu Gln Arg Lys  Thr Phe Val Glu Leu  Met Arg Arg 
    2000                 2005                 2010             


Gly Asp  Leu Pro Val Trp Leu  Ser Tyr Lys Val Ala  Ser Ala Gly 
    2015                 2020                 2025             


Ile Ser  Tyr Lys Asp Arg Glu  Trp Cys Phe Thr Gly  Glu Arg Asn 
    2030                 2035                 2040             


Asn Gln  Ile Leu Glu Glu Asn  Met Glu Val Glu Ile  Trp Thr Arg 
    2045                 2050                 2055             


Glu Gly  Glu Lys Lys Lys Leu  Arg Pro Arg Trp Leu  Asp Ala Arg 
    2060                 2065                 2070             


Val Tyr  Ala Asp Pro Met Ala  Leu Lys Asp Phe Lys  Glu Phe Ala 
    2075                 2080                 2085             


Ser Gly  Arg Lys Ser Ile Thr  Leu Asp Ile Leu Thr  Glu Ile Ala 
    2090                 2095                 2100             


Ser Leu  Pro Thr Tyr Leu Ser  Ser Arg Ala Lys Leu  Ala Leu Asp 
    2105                 2110                 2115             


Asn Ile  Val Met Leu His Thr  Thr Glu Arg Gly Gly  Arg Ala Tyr 
    2120                 2125                 2130             


Gln His  Ala Leu Asn Glu Leu  Pro Glu Ser Leu Glu  Thr Leu Met 
    2135                 2140                 2145             


Leu Val  Ala Leu Leu Gly Ala  Met Thr Ala Gly Ile  Phe Leu Phe 
    2150                 2155                 2160             


Phe Met  Gln Gly Lys Gly Ile  Gly Lys Leu Ser Met  Gly Leu Ile 
    2165                 2170                 2175             


Thr Ile  Ala Val Ala Ser Gly  Leu Leu Trp Val Ala  Glu Ile Gln 
    2180                 2185                 2190             


Pro Gln  Trp Ile Ala Ala Ser  Ile Ile Leu Glu Phe  Phe Leu Met 
    2195                 2200                 2205             


Val Leu  Leu Ile Pro Glu Pro  Glu Lys Gln Arg Thr  Pro Gln Asp 
    2210                 2215                 2220             


Asn Gln  Leu Ile Tyr Val Ile  Leu Thr Ile Leu Thr  Ile Ile Gly 
    2225                 2230                 2235             


Leu Ile  Ala Ala Asn Glu Met  Gly Leu Ile Glu Lys  Thr Lys Thr 
    2240                 2245                 2250             


Asp Phe  Gly Phe Tyr Gln Val  Lys Thr Glu Thr Thr  Ile Leu Asp 
    2255                 2260                 2265             


Val Asp  Leu Arg Pro Ala Ser  Ala Trp Thr Leu Tyr  Ala Val Ala 
    2270                 2275                 2280             


Thr Thr  Ile Leu Thr Pro Met  Leu Arg His Thr Ile  Glu Asn Thr 
    2285                 2290                 2295             


Ser Ala  Asn Leu Ser Leu Ala  Ala Ile Ala Asn Gln  Ala Ala Val 
    2300                 2305                 2310             


Leu Met  Gly Leu Gly Lys Gly  Trp Pro Leu His Arg  Met Asp Leu 
    2315                 2320                 2325             


Gly Val  Pro Leu Leu Ala Met  Gly Cys Tyr Ser Gln  Val Asn Pro 
    2330                 2335                 2340             


Thr Thr  Leu Thr Ala Ser Leu  Val Met Leu Leu Val  His Tyr Ala 
    2345                 2350                 2355             


Ile Ile  Gly Pro Gly Leu Gln  Ala Lys Ala Thr Arg  Glu Ala Gln 
    2360                 2365                 2370             


Lys Arg  Thr Ala Ala Gly Ile  Met Lys Asn Pro Thr  Val Asp Gly 
    2375                 2380                 2385             


Ile Thr  Val Ile Asp Leu Glu  Pro Ile Ser Tyr Asp  Pro Lys Phe 
    2390                 2395                 2400             


Glu Lys  Gln Leu Gly Gln Val  Met Leu Leu Val Leu  Cys Ala Gly 
    2405                 2410                 2415             


Gln Leu  Leu Leu Met Arg Thr  Thr Trp Ala Phe Cys  Glu Val Leu 
    2420                 2425                 2430             


Thr Leu  Ala Thr Gly Pro Ile  Leu Thr Leu Trp Glu  Gly Asn Pro 
    2435                 2440                 2445             


Gly Arg  Phe Trp Asn Thr Thr  Ile Ala Val Ser Thr  Ala Asn Ile 
    2450                 2455                 2460             


Phe Arg  Gly Ser Tyr Leu Ala  Gly Ala Gly Leu Ala  Phe Ser Leu 
    2465                 2470                 2475             


Ile Lys  Asn Ala Gln Thr Pro  Arg Arg Gly Thr Gly  Thr Thr Gly 
    2480                 2485                 2490             


Glu Thr  Leu Gly Glu Lys Trp  Lys Arg Gln Leu Asn  Ser Leu Asp 
    2495                 2500                 2505             


Arg Lys  Glu Phe Glu Glu Tyr  Lys Arg Ser Gly Ile  Leu Glu Val 
    2510                 2515                 2520             


Asp Arg  Thr Glu Ala Lys Ser  Ala Leu Lys Asp Gly  Ser Lys Ile 
    2525                 2530                 2535             


Lys His  Ala Val Ser Arg Gly  Ser Ser Lys Ile Arg  Trp Ile Val 
    2540                 2545                 2550             


Glu Arg  Gly Met Val Lys Pro  Lys Gly Lys Val Val  Asp Leu Gly 
    2555                 2560                 2565             


Cys Gly  Arg Gly Gly Trp Ser  Tyr Tyr Met Ala Thr  Leu Lys Asn 
    2570                 2575                 2580             


Val Thr  Glu Val Lys Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu 
    2585                 2590                 2595             


Glu Pro  Ile Pro Met Ala Thr  Tyr Gly Trp Asn Leu  Val Lys Leu 
    2600                 2605                 2610             


His Ser  Gly Val Asp Val Phe  Tyr Lys Pro Thr Glu  Gln Val Asp 
    2615                 2620                 2625             


Thr Leu  Leu Cys Asp Ile Gly  Glu Ser Ser Ser Asn  Pro Thr Ile 
    2630                 2635                 2640             


Glu Glu  Gly Arg Thr Leu Arg  Val Leu Lys Met Val  Glu Pro Trp 
    2645                 2650                 2655             


Leu Ser  Ser Lys Pro Glu Phe  Cys Ile Lys Val Leu  Asn Pro Tyr 
    2660                 2665                 2670             


Met Pro  Thr Val Ile Glu Glu  Leu Glu Lys Leu Gln  Arg Lys His 
    2675                 2680                 2685             


Gly Gly  Asn Leu Val Arg Cys  Pro Leu Ser Arg Asn  Ser Thr His 
    2690                 2695                 2700             


Glu Met  Tyr Trp Val Ser Gly  Ala Ser Gly Asn Ile  Val Ser Ser 
    2705                 2710                 2715             


Val Asn  Thr Thr Ser Lys Met  Leu Leu Asn Arg Phe  Thr Thr Arg 
    2720                 2725                 2730             


His Arg  Lys Pro Thr Tyr Glu  Lys Asp Val Asp Leu  Gly Ala Gly 
    2735                 2740                 2745             


Thr Arg  Ser Val Ser Thr Glu  Thr Glu Lys Pro Asp  Met Thr Ile 
    2750                 2755                 2760             


Ile Gly  Arg Arg Leu Gln Arg  Leu Gln Glu Glu His  Lys Glu Thr 
    2765                 2770                 2775             


Trp His  Tyr Asp Gln Glu Asn  Pro Tyr Arg Thr Trp  Ala Tyr His 
    2780                 2785                 2790             


Gly Ser  Tyr Glu Ala Pro Ser  Thr Gly Ser Ala Ser  Ser Met Val 
    2795                 2800                 2805             


Asn Gly  Val Val Lys Leu Leu  Thr Lys Pro Trp Asp  Val Val Pro 
    2810                 2815                 2820             


Met Val  Thr Gln Leu Ala Met  Thr Asp Thr Thr Pro  Phe Gly Gln 
    2825                 2830                 2835             


Gln Arg  Val Phe Lys Glu Lys  Val Asp Thr Arg Thr  Pro Gln Pro 
    2840                 2845                 2850             


Lys Pro  Gly Thr Arg Met Val  Met Thr Thr Thr Ala  Asn Trp Leu 
    2855                 2860                 2865             


Trp Ala  Leu Leu Gly Lys Lys  Lys Asn Pro Arg Leu  Cys Thr Arg 
    2870                 2875                 2880             


Glu Glu  Phe Ile Ser Lys Val  Arg Ser Asn Ala Ala  Ile Gly Ala 
    2885                 2890                 2895             


Val Phe  Gln Glu Glu Gln Gly  Trp Thr Ser Ala Ser  Glu Ala Val 
    2900                 2905                 2910             


Asn Asp  Ser Arg Phe Trp Glu  Leu Val Asp Lys Glu  Arg Ala Leu 
    2915                 2920                 2925             


His Gln  Glu Gly Lys Cys Glu  Ser Cys Val Tyr Asn  Met Met Gly 
    2930                 2935                 2940             


Lys Arg  Glu Lys Lys Leu Gly  Glu Phe Gly Arg Ala  Lys Gly Ser 
    2945                 2950                 2955             


Arg Ala  Ile Trp Tyr Met Trp  Leu Gly Ala Arg Phe  Leu Glu Phe 
    2960                 2965                 2970             


Glu Ala  Leu Gly Phe Leu Asn  Glu Asp His Trp Phe  Gly Arg Glu 
    2975                 2980                 2985             


Asn Ser  Trp Ser Gly Val Glu  Gly Glu Gly Leu His  Arg Leu Gly 
    2990                 2995                 3000             


Tyr Ile  Leu Glu Glu Ile Asp  Lys Lys Asp Gly Asp  Leu Met Tyr 
    3005                 3010                 3015             


Ala Asp  Asp Thr Ala Gly Trp  Asp Thr Arg Ile Thr  Glu Asp Asp 
    3020                 3025                 3030             


Leu Gln  Asn Glu Glu Leu Ile  Thr Glu Gln Met Ala  Pro His His 
    3035                 3040                 3045             


Lys Ile  Leu Ala Lys Ala Ile  Phe Lys Leu Thr Tyr  Gln Asn Lys 
    3050                 3055                 3060             


Val Val  Lys Val Leu Arg Pro  Thr Pro Arg Gly Ala  Val Met Asp 
    3065                 3070                 3075             


Ile Ile  Ser Arg Lys Asp Gln  Arg Gly Ser Gly Gln  Val Gly Thr 
    3080                 3085                 3090             


Tyr Gly  Leu Asn Thr Phe Thr  Asn Met Glu Val Gln  Leu Ile Arg 
    3095                 3100                 3105             


Gln Met  Glu Ala Glu Gly Val  Ile Thr Gln Asp Asp  Met Gln Asn 
    3110                 3115                 3120             


Pro Lys  Gly Leu Lys Glu Arg  Val Glu Lys Trp Leu  Lys Glu Cys 
    3125                 3130                 3135             


Gly Val  Asp Arg Leu Lys Arg  Met Ala Ile Ser Gly  Asp Asp Cys 
    3140                 3145                 3150             


Val Val  Lys Pro Leu Asp Glu  Arg Phe Gly Thr Ser  Leu Leu Phe 
    3155                 3160                 3165             


Leu Asn  Asp Met Gly Lys Val  Arg Lys Asp Ile Pro  Gln Trp Glu 
    3170                 3175                 3180             


Pro Ser  Lys Gly Trp Lys Asn  Trp Gln Glu Val Pro  Phe Cys Ser 
    3185                 3190                 3195             


His His  Phe His Lys Ile Phe  Met Lys Asp Gly Arg  Ser Leu Val 
    3200                 3205                 3210             


Val Pro  Cys Arg Asn Gln Asp  Glu Leu Ile Gly Arg  Ala Arg Ile 
    3215                 3220                 3225             


Ser Gln  Gly Ala Gly Trp Ser  Leu Arg Glu Thr Ala  Cys Leu Gly 
    3230                 3235                 3240             


Lys Ala  Tyr Ala Gln Met Trp  Ser Leu Met Tyr Phe  His Arg Arg 
    3245                 3250                 3255             


Asp Leu  Arg Leu Ala Ser Met  Ala Ile Cys Ser Ala  Val Pro Thr 
    3260                 3265                 3270             


Glu Trp  Phe Pro Thr Ser Arg  Thr Thr Trp Ser Ile  His Ala His 
    3275                 3280                 3285             


His Gln  Trp Met Thr Thr Glu  Asp Met Leu Lys Val  Trp Asn Arg 
    3290                 3295                 3300             


Val Trp  Ile Glu Asp Asn Pro  Asn Met Thr Asp Lys  Thr Pro Val 
    3305                 3310                 3315             


His Ser  Trp Glu Asp Ile Pro  Tyr Leu Gly Lys Arg  Glu Asp Leu 
    3320                 3325                 3330             


Trp Cys  Gly Ser Leu Ile Gly  Leu Ser Ser Arg Ala  Thr Trp Ala 
    3335                 3340                 3345             


Lys Asn  Ile His Thr Ala Ile  Thr Gln Val Arg Asn  Leu Ile Gly 
    3350                 3355                 3360             


Lys Glu  Glu Tyr Val Asp Tyr  Met Pro Val Met Lys  Arg Tyr Ser 
    3365                 3370                 3375             


Ala Pro  Ser Glu Ser Glu Gly  Val Leu 
    3380                 3385         


<210>  11
<211>  10996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  West Nile/Dengue 1 virus chimera


<220>
<221>  CDS
<222>  (97)..(10365)

<400>  11
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcg atg tct aag aaa cca gga        114
                                        Met Ser Lys Lys Pro Gly           
                                        1               5                 

ggg ccc ggc aag agc cgg gct gtc aat atg cta aaa cgc gga atg ccc        162
Gly Pro Gly Lys Ser Arg Ala Val Asn Met Leu Lys Arg Gly Met Pro           
            10                  15                  20                    

cgc gtg ttg tcc ttg att gga ctg aag agg gct atg ttg agc ctg atc        210
Arg Val Leu Ser Leu Ile Gly Leu Lys Arg Ala Met Leu Ser Leu Ile           
        25                  30                  35                        

gac ggc aag ggg cca ata cga ttt gtg ttg gct ctc ttg gcg ttc ttc        258
Asp Gly Lys Gly Pro Ile Arg Phe Val Leu Ala Leu Leu Ala Phe Phe           
    40                  45                  50                            

agg ttc aca gca att gct ccg acc cga gca gtg ctg gat cga tgg aga        306
Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala Val Leu Asp Arg Trp Arg           
55                  60                  65                  70            

ggt gtg aac aaa caa aca gcg atg aaa cac ctt ctg agt ttt aag aag        354
Gly Val Asn Lys Gln Thr Ala Met Lys His Leu Leu Ser Phe Lys Lys           
                75                  80                  85                

gaa cta ggg acc ttg acc agt gct atc aat cgg cgg agt tcg aaa caa        402
Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn Arg Arg Ser Ser Lys Gln           
            90                  95                  100                   

aag aaa aga tcc gtg acc atg ctc ctt atg ctg ctg ccc aca gcc ctg        450
Lys Lys Arg Ser Val Thr Met Leu Leu Met Leu Leu Pro Thr Ala Leu           
        105                 110                 115                       

gcg ttc cat ctg acg aca cga ggg gga gag ccg cat atg ata gtt agc        498
Ala Phe His Leu Thr Thr Arg Gly Gly Glu Pro His Met Ile Val Ser           
    120                 125                 130                           

aag cag gaa aga gga aag tca ctt ttg ttc aag acc tct gca ggt gtc        546
Lys Gln Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ser Ala Gly Val           
135                 140                 145                 150           

aac atg tgc acc ctc att gcg atg gat ttg gga gag ttg tgt gag gac        594
Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Leu Cys Glu Asp           
                155                 160                 165               

acg atg acc tac aaa tgc ccc cgg atc act gag gcg gaa cca gat gac        642
Thr Met Thr Tyr Lys Cys Pro Arg Ile Thr Glu Ala Glu Pro Asp Asp           
            170                 175                 180                   

gtt gac tgt tgg tgc aat gcc acg gac aca tgg gtg acc tat gga acg        690
Val Asp Cys Trp Cys Asn Ala Thr Asp Thr Trp Val Thr Tyr Gly Thr           
        185                 190                 195                       

tgc tct caa act ggc gaa cac cga cga gac aaa cgt tcc gtc gca ttg        738
Cys Ser Gln Thr Gly Glu His Arg Arg Asp Lys Arg Ser Val Ala Leu           
    200                 205                 210                           

gcc cca cac gtg ggg ctt ggc cta gaa aca aga gcc gaa acg tgg atg        786
Ala Pro His Val Gly Leu Gly Leu Glu Thr Arg Ala Glu Thr Trp Met           
215                 220                 225                 230           

tcc tct gaa ggt gct tgg aaa cag ata caa aaa gta gag act tgg gct        834
Ser Ser Glu Gly Ala Trp Lys Gln Ile Gln Lys Val Glu Thr Trp Ala           
                235                 240                 245               

ctg aga cat cca gga ttc acg gtg ata gcc ctt ttt cta gca cat gcc        882
Leu Arg His Pro Gly Phe Thr Val Ile Ala Leu Phe Leu Ala His Ala           
            250                 255                 260                   

ata gga aca tcc atc acc cag aaa ggg atc att ttc att ttg ctg atg        930
Ile Gly Thr Ser Ile Thr Gln Lys Gly Ile Ile Phe Ile Leu Leu Met           
        265                 270                 275                       

ctg gta aca cca tct atg gcc atg cga tgc gtg gga ata ggc aac aga        978
Leu Val Thr Pro Ser Met Ala Met Arg Cys Val Gly Ile Gly Asn Arg           
    280                 285                 290                           

gac ttc gtg gaa gga ctg tca gga gca aca tgg gtg gat gtg gta ctg       1026
Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val Val Leu           
295                 300                 305                 310           

gag cat gga agt tgc gtc acc acc atg gca aaa aac aaa cca aca ctg       1074
Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu           
                315                 320                 325               

gac att gaa ctc ttg aag acg gag gtc aca aac cct gca gtt ctg cgt       1122
Asp Ile Glu Leu Leu Lys Thr Glu Val Thr Asn Pro Ala Val Leu Arg           
            330                 335                 340                   

aaa ttg tgc att gaa gct aaa ata tca aac acc acc acc gat tcg aga       1170
Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser Arg           
        345                 350                 355                       

tgt cca aca caa gga gaa gcc aca ctg gtg gaa gaa caa gac gcg aac       1218
Cys Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Ala Asn           
    360                 365                 370                           

ttt gtg tgc cga cga acg ttc gtg gac aga ggc tgg ggc aat ggc tgt       1266
Phe Val Cys Arg Arg Thr Phe Val Asp Arg Gly Trp Gly Asn Gly Cys           
375                 380                 385                 390           

ggg cta ttc gga aaa ggt agt cta ata acg tgt gcc aag ttt aag tgt       1314
Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys Cys           
                395                 400                 405               

gtg aca aaa cta gaa gga aag ata gtt caa tat gaa aac cta aaa tat       1362
Val Thr Lys Leu Glu Gly Lys Ile Val Gln Tyr Glu Asn Leu Lys Tyr           
            410                 415                 420                   

tca gtg ata gtc acc gtc cac act gga gat cag cac cag gtg gga aat       1410
Ser Val Ile Val Thr Val His Thr Gly Asp Gln His Gln Val Gly Asn           
        425                 430                 435                       

gag act aca gaa cat gga aca act gca acc ata aca cct caa gct cct       1458
Glu Thr Thr Glu His Gly Thr Thr Ala Thr Ile Thr Pro Gln Ala Pro           
    440                 445                 450                           

acg tcg gaa ata cag ctg acc gac tac gga acc ctt aca tta gat tgt       1506
Thr Ser Glu Ile Gln Leu Thr Asp Tyr Gly Thr Leu Thr Leu Asp Cys           
455                 460                 465                 470           

tca cct agg aca ggg cta gat ttt aac gag atg gtg ttg ctg aca atg       1554
Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Thr Met           
                475                 480                 485               

aaa gaa aga tca tgg ctt gtc cac aaa caa tgg ttc cta gac tta cca       1602
Lys Glu Arg Ser Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu Pro           
            490                 495                 500                   

ctg cct tgg acc tct ggg gct tca aca tcc caa gag act tgg aac aga       1650
Leu Pro Trp Thr Ser Gly Ala Ser Thr Ser Gln Glu Thr Trp Asn Arg           
        505                 510                 515                       

caa gat tta ctg gtc aca ttt aag aca gct cat gca aag aag cag gaa       1698
Gln Asp Leu Leu Val Thr Phe Lys Thr Ala His Ala Lys Lys Gln Glu           
    520                 525                 530                           

gta gtc gta cta gga tca caa gaa gga gca atg cac act gcg ctg act       1746
Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr           
535                 540                 545                 550           

gga gcg aca gaa atc caa acg tca gga acg aca aca att ttc gca gga       1794
Gly Ala Thr Glu Ile Gln Thr Ser Gly Thr Thr Thr Ile Phe Ala Gly           
                555                 560                 565               

cac cta aaa tgc aga cta aaa atg gac aaa cta act tta aaa ggg atg       1842
His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Thr Leu Lys Gly Met           
            570                 575                 580                   

tca tat gtg atg tgc aca ggc tca ttc aag tta gag aaa gaa gtg gct       1890
Ser Tyr Val Met Cys Thr Gly Ser Phe Lys Leu Glu Lys Glu Val Ala           
        585                 590                 595                       

gag acc cag cat gga act gtt ctg gtg cag gtt aaa tat gaa gga aca       1938
Glu Thr Gln His Gly Thr Val Leu Val Gln Val Lys Tyr Glu Gly Thr           
    600                 605                 610                           

gac gca cca tgc aag att ccc ttt tcg acc caa gat gag aaa gga gca       1986
Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Gln Asp Glu Lys Gly Ala           
615                 620                 625                 630           

acc cag aat ggg aga tta ata aca gcc aac ccc ata gtc act gac aaa       2034
Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn Pro Ile Val Thr Asp Lys           
                635                 640                 645               

gaa aaa cca gtc aat att gag gca gaa cca ccc ttt ggt gag agc tac       2082
Glu Lys Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser Tyr           
            650                 655                 660                   

atc gtg gta gga gca ggt gaa aaa gct ttg aaa cta agc tgg ttc aag       2130
Ile Val Val Gly Ala Gly Glu Lys Ala Leu Lys Leu Ser Trp Phe Lys           
        665                 670                 675                       

aaa gga agc agc ata ggg aaa atg ttt gaa gca act gcc cga gga gca       2178
Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly Ala           
    680                 685                 690                           

cga agg atg gcc att ctg gga gac acc gca tgg gac ttc ggt tct ata       2226
Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile           
695                 700                 705                 710           

gga gga gtg ttc acg tct atg gga aaa ctg gta cac cag gtt ttt gga       2274
Gly Gly Val Phe Thr Ser Met Gly Lys Leu Val His Gln Val Phe Gly           
                715                 720                 725               

act gca tat gga gtt ttg ttt agc gga gtt tct tgg acc atg aaa ata       2322
Thr Ala Tyr Gly Val Leu Phe Ser Gly Val Ser Trp Thr Met Lys Ile           
            730                 735                 740                   

gga ata ggg att ctg ctg aca tgg cta gga tta aat tca agg aac acg       2370
Gly Ile Gly Ile Leu Leu Thr Trp Leu Gly Leu Asn Ser Arg Asn Thr           
        745                 750                 755                       

tcc ctt tcg atg atg tgc atc gca gtt ggc atg gtc aca ctg tac cta       2418
Ser Leu Ser Met Met Cys Ile Ala Val Gly Met Val Thr Leu Tyr Leu           
    760                 765                 770                           

gga gtc atg gtt cag gca gat tcc gga tgt gcc ata gac atc agc cgg       2466
Gly Val Met Val Gln Ala Asp Ser Gly Cys Ala Ile Asp Ile Ser Arg           
775                 780                 785                 790           

caa gag ctg aga tgt gga agt gga gtg ttc ata cac aat gat gtg gag       2514
Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile His Asn Asp Val Glu           
                795                 800                 805               

gct tgg atg gac cgg tac aag tat tac cct gaa acg cca caa ggc cta       2562
Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu Thr Pro Gln Gly Leu           
            810                 815                 820                   

gcc aag atc att cag aaa gct cat aag gaa gga gtg tgc ggt cta cga       2610
Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly Val Cys Gly Leu Arg           
        825                 830                 835                       

tca gtt tcc aga ctg gag cat caa atg tgg gaa gca gtg aag gac gag       2658
Ser Val Ser Arg Leu Glu His Gln Met Trp Glu Ala Val Lys Asp Glu           
    840                 845                 850                           

ctg aac act ctt ttg aag gag aat ggt gtg gac ctt agt gtc gtg gtt       2706
Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp Leu Ser Val Val Val           
855                 860                 865                 870           

gag aaa cag gag gga atg tac aag tca gca cct aaa cgc ctc acc gcc       2754
Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro Lys Arg Leu Thr Ala           
                875                 880                 885               

acc acg gaa aaa ttg gaa att ggc tgg aag gcc tgg gga aag agt att       2802
Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala Trp Gly Lys Ser Ile           
            890                 895                 900                   

tta ttt gca cca gaa ctc gcc aac aac acc ttt gtg gtt gat ggt ccg       2850
Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe Val Val Asp Gly Pro           
        905                 910                 915                       

gag acc aag gaa tgt ccg act cag aat cgc gct tgg aat agc tta gaa       2898
Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala Trp Asn Ser Leu Glu           
    920                 925                 930                           

gtg gag gat ttt gga ttt ggt ctc acc agc act cgg atg ttc ctg aag       2946
Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr Arg Met Phe Leu Lys           
935                 940                 945                 950           

gtc aga gag agc aac aca act gaa tgt gac tcg aag atc att gga acg       2994
Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser Lys Ile Ile Gly Thr           
                955                 960                 965               

gct gtc aag aac aac ttg gcg atc cac agt gac ctg tcc tat tgg att       3042
Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp Leu Ser Tyr Trp Ile           
            970                 975                 980                   

gaa agc agg ctc aat gat acg tgg aag ctt gaa agg gca gtt ctg ggt       3090
Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu Glu Arg Ala Val Leu Gly           
        985                 990                 995                       

gaa gtc  aaa tca tgt acg tgg  cct gag acg cat acc  ttg tgg ggc        3135
Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr His Thr  Leu Trp Gly            
    1000                 1005                 1010                        

gat gga  atc ctt gag agt gac  ttg ata ata cca gtc  aca ctg gcg        3180
Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile Pro Val  Thr Leu Ala            
    1015                 1020                 1025                        

gga cca  cga agc aat cac aat  cgg aga cct ggg tac  aag aca caa        3225
Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro Gly Tyr  Lys Thr Gln            
    1030                 1035                 1040                        

aac cag  ggc cca tgg gac gaa  ggc cgg gta gag att  gac ttc gat        3270
Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val Glu Ile  Asp Phe Asp            
    1045                 1050                 1055                        

tac tgc  cca gga act acg gtc  acc ctg agt gag agc  tgc gga cac        3315
Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser Glu Ser  Cys Gly His            
    1060                 1065                 1070                        

cgt gga  cct gcc act cgc acc  acc aca gag agc gga  aag ttg ata        3360
Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu Ser Gly  Lys Leu Ile            
    1075                 1080                 1085                        

aca gat  tgg tgc tgc agg agc  tgc acc tta cca cca  ctg cgc tac        3405
Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr            
    1090                 1095                 1100                        

caa act  gac agc ggc tgt tgg  tat ggt atg gag atc  aga cca cag        3450
Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Gln            
    1105                 1110                 1115                        

aga cat  gat gaa aag acc ctc  gtg cag tca caa gtg  aat gct tat        3495
Arg His  Asp Glu Lys Thr Leu  Val Gln Ser Gln Val  Asn Ala Tyr            
    1120                 1125                 1130                        

aat gct  gat atg att gac cct  ttt cag ttg ggc ctt  ctg gtc gtg        3540
Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu Gly Leu  Leu Val Val            
    1135                 1140                 1145                        

ttc ttg  gcc acc cag gag gtc  ctt cgc aag agg tgg  aca gcc aag        3585
Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys Arg Trp  Thr Ala Lys            
    1150                 1155                 1160                        

atc agc  atg cca gct ata ctg  att gct ctg cta gtc  ctg gtg ttt        3630
Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu Leu Val  Leu Val Phe            
    1165                 1170                 1175                        

ggg ggc  att act tac act gat  gtg tta cgc tat gtc  atc ttg gtg        3675
Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg Tyr Val  Ile Leu Val            
    1180                 1185                 1190                        

ggg gca  gct ttc gca gaa tct  aat tcg gga gga gac  gtg gta cac        3720
Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly Gly Asp  Val Val His            
    1195                 1200                 1205                        

ttg gcg  ctc atg gcg acc ttc  aag ata caa cca gtg  ttt atg gtg        3765
Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln Pro Val  Phe Met Val            
    1210                 1215                 1220                        

gca tcg  ttt ctc aaa gcg aga  tgg acc aac cag gag  aac att ttg        3810
Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn Gln Glu  Asn Ile Leu            
    1225                 1230                 1235                        

ttg atg  ttg gcg gct gtt ttc  ttt caa atg gct tat  tac gat gcc        3855
Leu Met  Leu Ala Ala Val Phe  Phe Gln Met Ala Tyr  Tyr Asp Ala            
    1240                 1245                 1250                        

cgc caa  att ctg ctc tgg gag  atc cct gat gtg ttg  aat tca ctg        3900
Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp Val Leu  Asn Ser Leu            
    1255                 1260                 1265                        

gcg gta  gct tgg atg ata ctg  aga gcc ata aca ttc  aca acg aca        3945
Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile Thr Phe  Thr Thr Thr            
    1270                 1275                 1280                        

tca aac  gtg gtt gtt ccg ctg  cta gcc ctg cta aca  ccc ggg ctg        3990
Ser Asn  Val Val Val Pro Leu  Leu Ala Leu Leu Thr  Pro Gly Leu            
    1285                 1290                 1295                        

aga tgc  ttg aat ctg gat gtg  tac agg ata ctg ctg  ttg atg gtc        4035
Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile Leu Leu  Leu Met Val            
    1300                 1305                 1310                        

gga ata  ggc agc ttg atc agg  gag aag agg agt gca  gct gca aaa        4080
Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg Ser Ala  Ala Ala Lys            
    1315                 1320                 1325                        

aag aaa  gga gca agt ctg cta  tgc ttg gct cta gcc  tca aca gga        4125
Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala Leu Ala  Ser Thr Gly            
    1330                 1335                 1340                        

ctt ttc  aac ccc atg atc ctt  gct gct gga ctg att  gca tgt gat        4170
Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly Leu Ile  Ala Cys Asp            
    1345                 1350                 1355                        

ccc aac  cgt aaa cgc gga tgg  ccc gca act gaa gtg  atg aca gct        4215
Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr Glu Val  Met Thr Ala            
    1360                 1365                 1370                        

gtc ggc  cta atg ttt gcc atc  gtc gga ggg ctg gca  gag ctt gac        4260
Val Gly  Leu Met Phe Ala Ile  Val Gly Gly Leu Ala  Glu Leu Asp            
    1375                 1380                 1385                        

att gac  tcc atg gcc att cca  atg act atc gcg ggg  ctc atg ttt        4305
Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile Ala Gly  Leu Met Phe            
    1390                 1395                 1400                        

gct gct  ttc gtg att tct ggg  aaa tca aca gat atg  tgg att gag        4350
Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr Asp Met  Trp Ile Glu            
    1405                 1410                 1415                        

aga acg  gcg gac att tcc tgg  gaa agt gat gca gaa  att aca ggc        4395
Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp Ala Glu  Ile Thr Gly            
    1420                 1425                 1430                        

tcg agc  gaa aga gtt gat gtg  cgg ctt gat gat gat  gga aac ttc        4440
Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp Asp Asp  Gly Asn Phe            
    1435                 1440                 1445                        

cag ctc  atg aat gat cca gga  gca cct tgg aag ata  tgg atg ctc        4485
Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp Lys Ile  Trp Met Leu            
    1450                 1455                 1460                        

aga atg  gtc tgt ctc gcg att  agt gcg tac acc ccc  tgg gca atc        4530
Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr Thr Pro  Trp Ala Ile            
    1465                 1470                 1475                        

ttg ccc  tca gta gtt gga ttt  tgg ata act ctc caa  tac aca aag        4575
Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr Leu Gln  Tyr Thr Lys            
    1480                 1485                 1490                        

aga gga  ggc gtg ttg tgg gac  act ccc tca cca aag  gag tac aaa        4620
Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser Pro Lys  Glu Tyr Lys            
    1495                 1500                 1505                        

aag ggg  gac acg acc acc ggc  gtc tac agg atc atg  act cgt ggg        4665
Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg Ile Met  Thr Arg Gly            
    1510                 1515                 1520                        

ctg ctc  ggc agt tat caa gca  gga gcg ggc gtg atg  gtt gaa ggt        4710
Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly Val Met  Val Glu Gly            
    1525                 1530                 1535                        

gtt ttc  cac acc ctt tgg cat  aca aca aaa gga gcc  gct ttg atg        4755
Val Phe  His Thr Leu Trp His  Thr Thr Lys Gly Ala  Ala Leu Met            
    1540                 1545                 1550                        

agc gga  gag ggc cgc ctg gac  cca tac tgg ggc agt  gtc aag gag        4800
Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp Gly Ser  Val Lys Glu            
    1555                 1560                 1565                        

gat cga  ctt tgt tac gga gga  ccc tgg aaa ttg cag  cac aag tgg        4845
Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys Leu Gln  His Lys Trp            
    1570                 1575                 1580                        

aac ggg  cag gat gag gtg cag  atg att gtg gtg gaa  cct ggc agg        4890
Asn Gly  Gln Asp Glu Val Gln  Met Ile Val Val Glu  Pro Gly Arg            
    1585                 1590                 1595                        

aac gtt  aag aac gtc cag acg  aaa cca ggg gtg ttc  aaa aca cct        4935
Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly Val Phe  Lys Thr Pro            
    1600                 1605                 1610                        

gaa gga  gaa atc ggg gcc gtg  act ttg gac ttc ccc  act gga aca        4980
Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp Phe Pro  Thr Gly Thr            
    1615                 1620                 1625                        

tca ggc  tca cca ata gtg gac  aaa aac ggt gat gtg  att ggg ctt        5025
Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly Asp Val  Ile Gly Leu            
    1630                 1635                 1640                        

tat ggc  aat gga gtc ata atg  ccc aac ggc tca tac  ata agc gcg        5070
Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly Ser Tyr  Ile Ser Ala            
    1645                 1650                 1655                        

ata gtg  cag ggt gaa agg atg  gat gag cca atc cca  gcc gga ttc        5115
Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro Ile Pro  Ala Gly Phe            
    1660                 1665                 1670                        

gaa cct  gag atg ctg agg aaa  aaa cag atc act gta  ctg gat ctc        5160
Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile Thr Val  Leu Asp Leu            
    1675                 1680                 1685                        

cat ccc  ggc gcc ggt aaa aca  agg agg att ctg cca  cag atc atc        5205
His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile Leu Pro  Gln Ile Ile            
    1690                 1695                 1700                        

aaa gag  gcc ata aac aga aga  ctg aga aca gcc gtg  cta gca cca        5250
Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr Ala Val  Leu Ala Pro            
    1705                 1710                 1715                        

acc agg  gtt gtg gct gct gag  atg gct gaa gca ctg  aga gga ctg        5295
Thr Arg  Val Val Ala Ala Glu  Met Ala Glu Ala Leu  Arg Gly Leu            
    1720                 1725                 1730                        

ccc atc  cgg tac cag aca tcc  gca gtg ccc aga gaa  cat aat gga        5340
Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro Arg Glu  His Asn Gly            
    1735                 1740                 1745                        

aat gag  att gtt gat gtc atg  tgt cat gct acc ctc  acc cac agg        5385
Asn Glu  Ile Val Asp Val Met  Cys His Ala Thr Leu  Thr His Arg            
    1750                 1755                 1760                        

ctg atg  tct cct cac agg gtg  ccg aac tac aac ctg  ttc gtg atg        5430
Leu Met  Ser Pro His Arg Val  Pro Asn Tyr Asn Leu  Phe Val Met            
    1765                 1770                 1775                        

gat gag  gct cat ttc acc gac  cca gct agc att gca  gca aga ggt        5475
Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly            
    1780                 1785                 1790                        

tac att  tcc aca aag gtc gag  cta ggg gag gcg gcg  gca ata ttc        5520
Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu Ala Ala  Ala Ile Phe            
    1795                 1800                 1805                        

atg aca  gcc acc cca cca ggc  act tca gat cca ttc  cca gag tcc        5565
Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp Pro Phe  Pro Glu Ser            
    1810                 1815                 1820                        

aat tca  cca att tcc gac tta  cag act gag atc ccg  gat cga gct        5610
Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu Ile Pro  Asp Arg Ala            
    1825                 1830                 1835                        

tgg aac  tct gga tac gaa tgg  atc aca gaa tac acc  ggg aag acg        5655
Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu Tyr Thr  Gly Lys Thr            
    1840                 1845                 1850                        

gtt tgg  ttt gtg cct agt gtc  aag atg ggg aat gag  att gcc ctt        5700
Val Trp  Phe Val Pro Ser Val  Lys Met Gly Asn Glu  Ile Ala Leu            
    1855                 1860                 1865                        

tgc cta  caa cgt gct gga aag  aaa gta gtc caa ttg  aac aga aag        5745
Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val Gln Leu  Asn Arg Lys            
    1870                 1875                 1880                        

tcg tac  gag acg gag tac cca  aaa tgt aag aac gat  gat tgg gac        5790
Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys Asn Asp  Asp Trp Asp            
    1885                 1890                 1895                        

ttt gtt  atc aca aca gac ata  tct gaa atg ggg gct  aac ttc aag        5835
Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys            
    1900                 1905                 1910                        

gcg agc  agg gtg att gac agc  cgg aag agt gtg aaa  cca acc atc        5880
Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser Val Lys  Pro Thr Ile            
    1915                 1920                 1925                        

ata aca  gaa gga gaa ggg aga  gtg atc ctg gga gaa  cca tct gca        5925
Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu Gly Glu  Pro Ser Ala            
    1930                 1935                 1940                        

gtg aca  gca gct agt gcc gcc  cag aga cgt gga cgt  atc ggt aga        5970
Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg            
    1945                 1950                 1955                        

aat ccg  tcg caa gtt ggt gat  gag tac tgt tat ggg  ggg cac acg        6015
Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys Tyr Gly  Gly His Thr            
    1960                 1965                 1970                        

aat gaa  gac gac tcg aac ttc  gcc cat tgg act gag  gca cga atc        6060
Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp Thr Glu  Ala Arg Ile            
    1975                 1980                 1985                        

atg ctg  gac aac atc aac atg  cca aac gga ctg atc  gct caa ttc        6105
Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly Leu Ile  Ala Gln Phe            
    1990                 1995                 2000                        

tac caa  cca gag cgt gag aag  gta tat acc atg gat  ggg gaa tac        6150
Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr Met Asp  Gly Glu Tyr            
    2005                 2010                 2015                        

cgg ctc  aga gga gaa gag aga  aaa aac ttt ctg gaa  ctg ttg agg        6195
Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe Leu Glu  Leu Leu Arg            
    2020                 2025                 2030                        

act gca  gat ctg cca gtt tgg  ctg gct tac aag gtt  gca gcg gct        6240
Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr Lys Val  Ala Ala Ala            
    2035                 2040                 2045                        

gga gtg  tca tac cac gac cgg  agg tgg tgc ttt gat  ggt cct agg        6285
Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys Phe Asp  Gly Pro Arg            
    2050                 2055                 2060                        

aca aac  aca att tta gaa gac  aac aac gaa gtg gaa  gtc atc acg        6330
Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu Val Glu  Val Ile Thr            
    2065                 2070                 2075                        

aag ctt  ggt gaa agg aag att  ctg agg ccg cgc tgg  att gac gcc        6375
Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro Arg Trp  Ile Asp Ala            
    2080                 2085                 2090                        

agg gtg  tac tcg gat cac cag  gca cta aag gcg ttc  aag gac ttc        6420
Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys Ala Phe  Lys Asp Phe            
    2095                 2100                 2105                        

gcc tcg  gga aaa cgt tct cag  ata ggg ctc att gag  gtt ctg gga        6465
Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu Ile Glu  Val Leu Gly            
    2110                 2115                 2120                        

aag atg  cct gag cac ttc atg  ggg aag aca tgg gaa  gca ctt gac        6510
Lys Met  Pro Glu His Phe Met  Gly Lys Thr Trp Glu  Ala Leu Asp            
    2125                 2130                 2135                        

acc atg  tac gtt gtg gcc act  gca gag aaa gga gga  aga gct cac        6555
Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys Gly Gly  Arg Ala His            
    2140                 2145                 2150                        

aga atg  gcc ctg gag gaa ctg  cca gat gct ctt cag  aca att gcc        6600
Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala Leu Gln  Thr Ile Ala            
    2155                 2160                 2165                        

ttg att  gcc tta ttg agt gtg  atg acc atg gga gta  ttc ttc ctc        6645
Leu Ile  Ala Leu Leu Ser Val  Met Thr Met Gly Val  Phe Phe Leu            
    2170                 2175                 2180                        

ctc atg  cag cgg aag ggc att  gga aag ata ggt ttg  gga ggc gct        6690
Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile Gly Leu  Gly Gly Ala            
    2185                 2190                 2195                        

gtc ttg  gga gtc gcg acc ttt  ttc tgt tgg atg gct  gaa gtt cca        6735
Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp Met Ala  Glu Val Pro            
    2200                 2205                 2210                        

gga acg  aag atc gcc gga atg  ttg ctg ctc tcc ctt  ctc ttg atg        6780
Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu Ser Leu  Leu Leu Met            
    2215                 2220                 2225                        

att gtg  cta att cct gag cca  gag aag caa cgt tcg  cag aca gac        6825
Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln Arg Ser  Gln Thr Asp            
    2230                 2235                 2240                        

aac cag  cta gcc gtg ttc ctg  att tgt gtc atg acc  ctt gtg agc        6870
Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val Met Thr  Leu Val Ser            
    2245                 2250                 2255                        

gca gtg  gca gcc aac gag atg  ggt tgg cta gat aag  acc aag agt        6915
Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu Asp Lys  Thr Lys Ser            
    2260                 2265                 2270                        

gac ata  agc agt ttg ttt ggg  caa aga att gag gtc  aag gag aat        6960
Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile Glu Val  Lys Glu Asn            
    2275                 2280                 2285                        

ttc agc  atg gga gag ttt ctt  ttg gac ttg agg cct  gca aca gcc        7005
Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu Arg Pro  Ala Thr Ala            
    2290                 2295                 2300                        

tgg tca  ctg tac gct gtg aca  aca gcg gtc ctc act  cca ctg cta        7050
Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val Leu Thr  Pro Leu Leu            
    2305                 2310                 2315                        

aag cat  ttg atc acg tca gat  tac atc aac acc tca  ttg acc tca        7095
Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn Thr Ser  Leu Thr Ser            
    2320                 2325                 2330                        

ata aac  gtt cag gca agt gca  cta ttc aca ctc gcg  cga ggc ttc        7140
Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr Leu Ala  Arg Gly Phe            
    2335                 2340                 2345                        

ccc ttc  gtc gat gtt gga gtg  tcg gct ctc ctg cta  gca gcc gga        7185
Pro Phe  Val Asp Val Gly Val  Ser Ala Leu Leu Leu  Ala Ala Gly            
    2350                 2355                 2360                        

tgc tgg  gga caa gtc acc ctc  acc gtt acg gta aca  gcg gca aca        7230
Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr Val Thr  Ala Ala Thr            
    2365                 2370                 2375                        

ctc ctt  ttt tgc cac tat gcc  tac atg gtt ccc ggt  tgg caa gct        7275
Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val Pro Gly  Trp Gln Ala            
    2380                 2385                 2390                        

gag gca  atg cgc tca gcc cag  cgg cgg aca gcg gcc  gga atc atg        7320
Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr Ala Ala  Gly Ile Met            
    2395                 2400                 2405                        

aag aac  gct gta gtg gat ggc  atc gtg gcc acg gac  gtc cca gaa        7365
Lys Asn  Ala Val Val Asp Gly  Ile Val Ala Thr Asp  Val Pro Glu            
    2410                 2415                 2420                        

tta gag  cgc acc aca ccc atc  atg cag aag aaa gtt  gga cag atc        7410
Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys Lys Val  Gly Gln Ile            
    2425                 2430                 2435                        

atg ctg  atc ttg gtg tct cta  gct gca gta gta gtg  aac ccg tct        7455
Met Leu  Ile Leu Val Ser Leu  Ala Ala Val Val Val  Asn Pro Ser            
    2440                 2445                 2450                        

gtg aag  aca gta cga gaa gcc  gga att ttg atc acg  gcc gca gcg        7500
Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu Ile Thr  Ala Ala Ala            
    2455                 2460                 2465                        

gtg acg  ctt tgg gag aat gga  gca agc tct gtt tgg  aac gca aca        7545
Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser Val Trp  Asn Ala Thr            
    2470                 2475                 2480                        

act gcc  atc gga ctc tgc cac  atc atg cgt ggg ggt  tgg ttg tca        7590
Thr Ala  Ile Gly Leu Cys His  Ile Met Arg Gly Gly  Trp Leu Ser            
    2485                 2490                 2495                        

tgt cta  tcc ata aca tgg aca  ctc ata aag aac atg  gaa aaa cca        7635
Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys Asn Met  Glu Lys Pro            
    2500                 2505                 2510                        

gga cta  aaa aga ggt ggg gca  aaa gga cgc acc ttg  gga gag gtt        7680
Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg Thr Leu  Gly Glu Val            
    2515                 2520                 2525                        

tgg aaa  gaa aga ctc aac cag  atg aca aaa gaa gag  ttc act agg        7725
Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys Glu Glu  Phe Thr Arg            
    2530                 2535                 2540                        

tac cgc  aaa gag gcc atc atc  gaa gtc gat cgc tca  gcg gca aaa        7770
Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp Arg Ser  Ala Ala Lys            
    2545                 2550                 2555                        

cac gcc  agg aaa gaa ggc aat  gtc act gga ggg cat  cca gtc tct        7815
His Ala  Arg Lys Glu Gly Asn  Val Thr Gly Gly His  Pro Val Ser            
    2560                 2565                 2570                        

agg ggc  aca gca aaa ctg aga  tgg ctg gtc gaa cgg  agg ttt ctc        7860
Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val Glu Arg  Arg Phe Leu            
    2575                 2580                 2585                        

gaa ccg  gtc gga aaa gtg att  gac ctt gga tgt gga  aga ggc ggt        7905
Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly Cys Gly  Arg Gly Gly            
    2590                 2595                 2600                        

tgg tgt  tac tat atg gca acc  caa aaa aga gtc caa  gaa gtc aga        7950
Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg Val Gln  Glu Val Arg            
    2605                 2610                 2615                        

ggg tac  aca aag ggc ggt ccc  gga cat gaa gag ccc  caa cta gtg        7995
Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu Glu Pro  Gln Leu Val            
    2620                 2625                 2630                        

caa agt  tat gga tgg aac att  gtc acc atg aag agt  gga gtg gat        8040
Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met Lys Ser  Gly Val Asp            
    2635                 2640                 2645                        

gtg ttc  tac aga cct tct gag  tgt tgt gac acc ctc  ctt tgt gac        8085
Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp Thr Leu  Leu Cys Asp            
    2650                 2655                 2660                        

atc gga  gag tcc tcg tca agt  gct gag gtt gaa gag  cat agg acg        8130
Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val Glu Glu  His Arg Thr            
    2665                 2670                 2675                        

att cgg  gtc ctt gaa atg gtt  gag gac tgg ctg cac  cga ggg cca        8175
Ile Arg  Val Leu Glu Met Val  Glu Asp Trp Leu His  Arg Gly Pro            
    2680                 2685                 2690                        

agg gaa  ttt tgc gtg aag gtg  ctc tgc ccc tac atg  ccg aaa gtc        8220
Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro Tyr Met  Pro Lys Val            
    2695                 2700                 2705                        

ata gag  aag atg gag ctg ctc  caa cgc cgg tat ggg  ggg gga ctg        8265
Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg Tyr Gly  Gly Gly Leu            
    2710                 2715                 2720                        

gtc aga  aac cca ctc tca cgg  aat tcc acg cac gag  atg tat tgg        8310
Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr His Glu  Met Tyr Trp            
    2725                 2730                 2735                        

gtg agt  cga gct tca ggc aat  gtg gta cat tca gtg  aat atg acc        8355
Val Ser  Arg Ala Ser Gly Asn  Val Val His Ser Val  Asn Met Thr            
    2740                 2745                 2750                        

agc cag  gtg ctc cta gga aga  atg gaa aaa agg acc  tgg aag gga        8400
Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys Arg Thr  Trp Lys Gly            
    2755                 2760                 2765                        

ccc caa  tac gag gaa gat gta  aac ttg gga agt gga  acc agg gcg        8445
Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly Ser Gly  Thr Arg Ala            
    2770                 2775                 2780                        

gtg gga  aaa ccc ctg ctc aac  tca gac acc agt aaa  atc aag aac        8490
Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr Ser Lys  Ile Lys Asn            
    2785                 2790                 2795                        

agg att  gaa cga ctc agg cgt  gag tac agt tcg acg  tgg cac cac        8535
Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser Ser Thr  Trp His His            
    2800                 2805                 2810                        

gat gag  aac cac cca tat aga  acc tgg aac tat cac  ggc agt tat        8580
Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn Tyr His  Gly Ser Tyr            
    2815                 2820                 2825                        

gat gtg  aag ccc aca ggc tcc  gcc agt tcg ctg gtc  aat gga gtg        8625
Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser Leu Val  Asn Gly Val            
    2830                 2835                 2840                        

gtc agg  ctc ctc tca aaa cca  tgg gac acc atc acg  aat gtt acc        8670
Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr Ile Thr  Asn Val Thr            
    2845                 2850                 2855                        

acc atg  gcc atg act gac act  act ccc ttc ggg cag  cag cga gtg        8715
Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe Gly Gln  Gln Arg Val            
    2860                 2865                 2870                        

ttc aaa  gag aag gtg gac acg  aaa gct cct gaa ccg  cca gaa gga        8760
Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro Glu Pro  Pro Glu Gly            
    2875                 2880                 2885                        

gtg aag  tac gtg ctc aac gag  acc acc aac tgg ttg  tgg gcg ttt        8805
Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn Trp Leu  Trp Ala Phe            
    2890                 2895                 2900                        

ttg gcc  aga gaa aaa cgt ccc  aga atg tgc tct cga  gag gaa ttc        8850
Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys Ser Arg  Glu Glu Phe            
    2905                 2910                 2915                        

ata aga  aag gtc aac agc aat  gca gct ttg ggt gcc  atg ttt gaa        8895
Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu Gly Ala  Met Phe Glu            
    2920                 2925                 2930                        

gag cag  aat caa tgg agg agc  gcc aga gaa gca gtt  gaa gat cca        8940
Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu Ala Val  Glu Asp Pro            
    2935                 2940                 2945                        

aaa ttt  tgg gag atg gtg gat  gag gag cgc gag gca  cat ctg cgg        8985
Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg Glu Ala  His Leu Arg            
    2950                 2955                 2960                        

ggg gaa  tgt cac act tgc att  tac aac atg atg gga  aag aga gag        9030
Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met Met Gly  Lys Arg Glu            
    2965                 2970                 2975                        

aaa aaa  ccc gga gag ttc gga  aag gcc aag gga agc  aga gcc att        9075
Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys Gly Ser  Arg Ala Ile            
    2980                 2985                 2990                        

tgg ttc  atg tgg ctc gga gct  cgc ttt ctg gag ttc  gag gct ctg        9120
Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu Glu Phe  Glu Ala Leu            
    2995                 3000                 3005                        

ggt ttt  ctc aat gaa gac cac  tgg ctt gga aga aag  aac tca gga        9165
Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly Arg Lys  Asn Ser Gly            
    3010                 3015                 3020                        

gga ggt  gtc gag ggc ttg ggc  ctc caa aaa ctg ggt  tac atc ctg        9210
Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys Leu Gly  Tyr Ile Leu            
    3025                 3030                 3035                        

cgt gaa  gtt ggc acc cgg cct  ggg ggc aag atc tat  gct gat gac        9255
Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys Ile Tyr  Ala Asp Asp            
    3040                 3045                 3050                        

aca gct  ggc tgg gac acc cgc  atc acg aga gct gac  ttg gaa aat        9300
Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg Ala Asp  Leu Glu Asn            
    3055                 3060                 3065                        

gaa gct  aag gtg ctt gag ctg  ctt gat ggg gaa cat  cgg cgt ctt        9345
Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly Glu His  Arg Arg Leu            
    3070                 3075                 3080                        

gcc agg  gcc atc att gag ctc  acc tat cgt cac aaa  gtt gtg aaa        9390
Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg His Lys  Val Val Lys            
    3085                 3090                 3095                        

gtg atg  cgc ccg gct gct gat  gga aga acc gtc atg  gat gtt atc        9435
Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr Val Met  Asp Val Ile            
    3100                 3105                 3110                        

tcc aga  gaa gat cag agg ggg  agt gga caa gtt gtc  acc tac gcc        9480
Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln Val Val  Thr Tyr Ala            
    3115                 3120                 3125                        

cta aac  act ttc acc aac ctg  gcc gtc cag ctg gtg  agg atg atg        9525
Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln Leu Val  Arg Met Met            
    3130                 3135                 3140                        

gaa ggg  gaa gga gtg att ggc  cca gat gat gtg gag  aaa ctc aca        9570
Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp Val Glu  Lys Leu Thr            
    3145                 3150                 3155                        

aaa ggg  aaa gga ccc aaa gtc  agg acc tgg ctg ttt  gag aat ggg        9615
Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp Leu Phe  Glu Asn Gly            
    3160                 3165                 3170                        

gaa gaa  aga ctc agc cgc atg  gct gtc agt gga gat  gac tgt gtg        9660
Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser Gly Asp  Asp Cys Val            
    3175                 3180                 3185                        

gta aag  ccc ctg gac gat cgc  ttt gcc acc tcg ctc  cac ttc ctc        9705
Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr Ser Leu  His Phe Leu            
    3190                 3195                 3200                        

aat gct  atg tca aag gtt cgc  aaa gac atc caa gag  tgg aaa ccg        9750
Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile Gln Glu  Trp Lys Pro            
    3205                 3210                 3215                        

tca act  gga tgg tat gat tgg  cag cag gtt cca ttt  tgc tca aac        9795
Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val Pro Phe  Cys Ser Asn            
    3220                 3225                 3230                        

cat ttc  act gaa ttg atc atg  aaa gat gga aga aca  ctg gtg gtt        9840
His Phe  Thr Glu Leu Ile Met  Lys Asp Gly Arg Thr  Leu Val Val            
    3235                 3240                 3245                        

cca tgc  cga gga cag gat gaa  ttg gta ggc aga gct  cgc ata tct        9885
Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly Arg Ala  Arg Ile Ser            
    3250                 3255                 3260                        

cca ggg  gcc gga tgg aac gtc  cgc gac act gct tgt  ctg gct aag        9930
Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr Ala Cys  Leu Ala Lys            
    3265                 3270                 3275                        

tct tat  gcc cag atg tgg ctg  ctt ctg tac ttc cac  aga aga gac        9975
Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr Phe His  Arg Arg Asp            
    3280                 3285                 3290                        

ctg cgg  ctc atg gcc aac gcc  att tgc tcc gct gtc  cct gtg aat       10020
Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser Ala Val  Pro Val Asn            
    3295                 3300                 3305                        

tgg gtc  cct acc gga aga acc  acg tgg tcc atc cat  gca gga gga       10065
Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser Ile His  Ala Gly Gly            
    3310                 3315                 3320                        

gag tgg  atg aca aca gag gac  atg ttg gag gtc tgg  aac cgt gtt       10110
Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu Val Trp  Asn Arg Val            
    3325                 3330                 3335                        

tgg ata  gag gag aat gaa tgg  atg gaa gac aaa acc  cca gtg gag       10155
Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp Lys Thr  Pro Val Glu            
    3340                 3345                 3350                        

aaa tgg  agt gac gtc cca tat  tca gga aaa cga gag  gac atc tgg       10200
Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys Arg Glu  Asp Ile Trp            
    3355                 3360                 3365                        

tgt ggc  agc ctg att ggc aca  aga gcc cga gcc acg  tgg gca gaa       10245
Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg Ala Thr  Trp Ala Glu            
    3370                 3375                 3380                        

aac atc  cag gtg gct atc aac  caa gtc aga gca atc  atc gga gat       10290
Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg Ala Ile  Ile Gly Asp            
    3385                 3390                 3395                        

gag aag  tat gtg gat tac atg  agt tca cta aag aga  tat gaa gac       10335
Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu Lys Arg  Tyr Glu Asp            
    3400                 3405                 3410                        

aca act  ttg gtt gag gac aca  gta ctg tag atatttaatc aattgtaaat      10385
Thr Thr  Leu Val Glu Asp Thr  Val Leu                                     
    3415                 3420                                             

agacaatata agtatgcata aaagtgtagt tttatagtag tatttagtgg tgttagtgta    10445

aatagttaag aaaattttga ggagaaagtc aggccgggaa gttcccgcca ccggaagttg    10505

agtagacggt gctgcctgcg actcaacccc aggaggactg ggtgaacaaa gccgcgaagt    10565

gatccatgta agccctcaga accgtctcgg aaggaggacc ccacatgttg taacttcaaa    10625

gcccaatgtc agaccacgct acggcgtgct actctgcgga gagtgcagtc tgcgatagtg    10685

ccccaggagg actgggttaa caaaggcaaa ccaacgcccc acgcggccct agccccggta    10745

atggtgttaa ccagggcgaa aggactagag gttagaggag accccgcggt ttaaagtgca    10805

cggcccagcc tggctgaagc tgtaggtcag gggaaggact agaggttagt ggagaccccg    10865

tgccacaaaa caccacaaca aaacagcata ttgacacctg ggatagacta ggagatcttc    10925

tgctctgcac aaccagccac acggcacagt gcgccgacaa tggtggctgg tggtgcgaga    10985

acacaggatc t                                                         10996


<210>  12
<211>  3422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Ser Val Thr Met Leu Leu Met 
            100                 105                 110         


Leu Leu Pro Thr Ala Leu Ala Phe His Leu Thr Thr Arg Gly Gly Glu 
        115                 120                 125             


Pro His Met Ile Val Ser Lys Gln Glu Arg Gly Lys Ser Leu Leu Phe 
    130                 135                 140                 


Lys Thr Ser Ala Gly Val Asn Met Cys Thr Leu Ile Ala Met Asp Leu 
145                 150                 155                 160 


Gly Glu Leu Cys Glu Asp Thr Met Thr Tyr Lys Cys Pro Arg Ile Thr 
                165                 170                 175     


Glu Ala Glu Pro Asp Asp Val Asp Cys Trp Cys Asn Ala Thr Asp Thr 
            180                 185                 190         


Trp Val Thr Tyr Gly Thr Cys Ser Gln Thr Gly Glu His Arg Arg Asp 
        195                 200                 205             


Lys Arg Ser Val Ala Leu Ala Pro His Val Gly Leu Gly Leu Glu Thr 
    210                 215                 220                 


Arg Ala Glu Thr Trp Met Ser Ser Glu Gly Ala Trp Lys Gln Ile Gln 
225                 230                 235                 240 


Lys Val Glu Thr Trp Ala Leu Arg His Pro Gly Phe Thr Val Ile Ala 
                245                 250                 255     


Leu Phe Leu Ala His Ala Ile Gly Thr Ser Ile Thr Gln Lys Gly Ile 
            260                 265                 270         


Ile Phe Ile Leu Leu Met Leu Val Thr Pro Ser Met Ala Met Arg Cys 
        275                 280                 285             


Val Gly Ile Gly Asn Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr 
    290                 295                 300                 


Trp Val Asp Val Val Leu Glu His Gly Ser Cys Val Thr Thr Met Ala 
305                 310                 315                 320 


Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Leu Lys Thr Glu Val Thr 
                325                 330                 335     


Asn Pro Ala Val Leu Arg Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn 
            340                 345                 350         


Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Thr Leu Val 
        355                 360                 365             


Glu Glu Gln Asp Ala Asn Phe Val Cys Arg Arg Thr Phe Val Asp Arg 
    370                 375                 380                 


Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr 
385                 390                 395                 400 


Cys Ala Lys Phe Lys Cys Val Thr Lys Leu Glu Gly Lys Ile Val Gln 
                405                 410                 415     


Tyr Glu Asn Leu Lys Tyr Ser Val Ile Val Thr Val His Thr Gly Asp 
            420                 425                 430         


Gln His Gln Val Gly Asn Glu Thr Thr Glu His Gly Thr Thr Ala Thr 
        435                 440                 445             


Ile Thr Pro Gln Ala Pro Thr Ser Glu Ile Gln Leu Thr Asp Tyr Gly 
    450                 455                 460                 


Thr Leu Thr Leu Asp Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu 
465                 470                 475                 480 


Met Val Leu Leu Thr Met Lys Glu Arg Ser Trp Leu Val His Lys Gln 
                485                 490                 495     


Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala Ser Thr Ser 
            500                 505                 510         


Gln Glu Thr Trp Asn Arg Gln Asp Leu Leu Val Thr Phe Lys Thr Ala 
        515                 520                 525             


His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln Glu Gly Ala 
    530                 535                 540                 


Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly Thr 
545                 550                 555                 560 


Thr Thr Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys 
                565                 570                 575     


Leu Thr Leu Lys Gly Met Ser Tyr Val Met Cys Thr Gly Ser Phe Lys 
            580                 585                 590         


Leu Glu Lys Glu Val Ala Glu Thr Gln His Gly Thr Val Leu Val Gln 
        595                 600                 605             


Val Lys Tyr Glu Gly Thr Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr 
    610                 615                 620                 


Gln Asp Glu Lys Gly Ala Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn 
625                 630                 635                 640 


Pro Ile Val Thr Asp Lys Glu Lys Pro Val Asn Ile Glu Ala Glu Pro 
                645                 650                 655     


Pro Phe Gly Glu Ser Tyr Ile Val Val Gly Ala Gly Glu Lys Ala Leu 
            660                 665                 670         


Lys Leu Ser Trp Phe Lys Lys Gly Ser Ser Ile Gly Lys Met Phe Glu 
        675                 680                 685             


Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly Asp Thr Ala 
    690                 695                 700                 


Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Thr Ser Met Gly Lys Leu 
705                 710                 715                 720 


Val His Gln Val Phe Gly Thr Ala Tyr Gly Val Leu Phe Ser Gly Val 
                725                 730                 735     


Ser Trp Thr Met Lys Ile Gly Ile Gly Ile Leu Leu Thr Trp Leu Gly 
            740                 745                 750         


Leu Asn Ser Arg Asn Thr Ser Leu Ser Met Met Cys Ile Ala Val Gly 
        755                 760                 765             


Met Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys 
    770                 775                 780                 


Ala Ile Asp Ile Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe 
785                 790                 795                 800 


Ile His Asn Asp Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro 
                805                 810                 815     


Glu Thr Pro Gln Gly Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu 
            820                 825                 830         


Gly Val Cys Gly Leu Arg Ser Val Ser Arg Leu Glu His Gln Met Trp 
        835                 840                 845             


Glu Ala Val Lys Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val 
    850                 855                 860                 


Asp Leu Ser Val Val Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala 
865                 870                 875                 880 


Pro Lys Arg Leu Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys 
                885                 890                 895     


Ala Trp Gly Lys Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr 
            900                 905                 910         


Phe Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg 
        915                 920                 925             


Ala Trp Asn Ser Leu Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser 
    930                 935                 940                 


Thr Arg Met Phe Leu Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp 
945                 950                 955                 960 


Ser Lys Ile Ile Gly Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser 
                965                 970                 975     


Asp Leu Ser Tyr Trp Ile Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu 
            980                 985                 990         


Glu Arg Ala Val Leu Gly Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr 
        995                 1000                 1005             


His Thr  Leu Trp Gly Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile 
    1010                 1015                 1020             


Pro Val  Thr Leu Ala Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro 
    1025                 1030                 1035             


Gly Tyr  Lys Thr Gln Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val 
    1040                 1045                 1050             


Glu Ile  Asp Phe Asp Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser 
    1055                 1060                 1065             


Glu Ser  Cys Gly His Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu 
    1070                 1075                 1080             


Ser Gly  Lys Leu Ile Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu 
    1085                 1090                 1095             


Pro Pro  Leu Arg Tyr Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met 
    1100                 1105                 1110             


Glu Ile  Arg Pro Gln Arg His  Asp Glu Lys Thr Leu  Val Gln Ser 
    1115                 1120                 1125             


Gln Val  Asn Ala Tyr Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu 
    1130                 1135                 1140             


Gly Leu  Leu Val Val Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys 
    1145                 1150                 1155             


Arg Trp  Thr Ala Lys Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu 
    1160                 1165                 1170             


Leu Val  Leu Val Phe Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg 
    1175                 1180                 1185             


Tyr Val  Ile Leu Val Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly 
    1190                 1195                 1200             


Gly Asp  Val Val His Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln 
    1205                 1210                 1215             


Pro Val  Phe Met Val Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn 
    1220                 1225                 1230             


Gln Glu  Asn Ile Leu Leu Met  Leu Ala Ala Val Phe  Phe Gln Met 
    1235                 1240                 1245             


Ala Tyr  Tyr Asp Ala Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp 
    1250                 1255                 1260             


Val Leu  Asn Ser Leu Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile 
    1265                 1270                 1275             


Thr Phe  Thr Thr Thr Ser Asn  Val Val Val Pro Leu  Leu Ala Leu 
    1280                 1285                 1290             


Leu Thr  Pro Gly Leu Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile 
    1295                 1300                 1305             


Leu Leu  Leu Met Val Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg 
    1310                 1315                 1320             


Ser Ala  Ala Ala Lys Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala 
    1325                 1330                 1335             


Leu Ala  Ser Thr Gly Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly 
    1340                 1345                 1350             


Leu Ile  Ala Cys Asp Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr 
    1355                 1360                 1365             


Glu Val  Met Thr Ala Val Gly  Leu Met Phe Ala Ile  Val Gly Gly 
    1370                 1375                 1380             


Leu Ala  Glu Leu Asp Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile 
    1385                 1390                 1395             


Ala Gly  Leu Met Phe Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr 
    1400                 1405                 1410             


Asp Met  Trp Ile Glu Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp 
    1415                 1420                 1425             


Ala Glu  Ile Thr Gly Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp 
    1430                 1435                 1440             


Asp Asp  Gly Asn Phe Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp 
    1445                 1450                 1455             


Lys Ile  Trp Met Leu Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr 
    1460                 1465                 1470             


Thr Pro  Trp Ala Ile Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr 
    1475                 1480                 1485             


Leu Gln  Tyr Thr Lys Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser 
    1490                 1495                 1500             


Pro Lys  Glu Tyr Lys Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg 
    1505                 1510                 1515             


Ile Met  Thr Arg Gly Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly 
    1520                 1525                 1530             


Val Met  Val Glu Gly Val Phe  His Thr Leu Trp His  Thr Thr Lys 
    1535                 1540                 1545             


Gly Ala  Ala Leu Met Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp 
    1550                 1555                 1560             


Gly Ser  Val Lys Glu Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys 
    1565                 1570                 1575             


Leu Gln  His Lys Trp Asn Gly  Gln Asp Glu Val Gln  Met Ile Val 
    1580                 1585                 1590             


Val Glu  Pro Gly Arg Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly 
    1595                 1600                 1605             


Val Phe  Lys Thr Pro Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp 
    1610                 1615                 1620             


Phe Pro  Thr Gly Thr Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly 
    1625                 1630                 1635             


Asp Val  Ile Gly Leu Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly 
    1640                 1645                 1650             


Ser Tyr  Ile Ser Ala Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro 
    1655                 1660                 1665             


Ile Pro  Ala Gly Phe Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile 
    1670                 1675                 1680             


Thr Val  Leu Asp Leu His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile 
    1685                 1690                 1695             


Leu Pro  Gln Ile Ile Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr 
    1700                 1705                 1710             


Ala Val  Leu Ala Pro Thr Arg  Val Val Ala Ala Glu  Met Ala Glu 
    1715                 1720                 1725             


Ala Leu  Arg Gly Leu Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro 
    1730                 1735                 1740             


Arg Glu  His Asn Gly Asn Glu  Ile Val Asp Val Met  Cys His Ala 
    1745                 1750                 1755             


Thr Leu  Thr His Arg Leu Met  Ser Pro His Arg Val  Pro Asn Tyr 
    1760                 1765                 1770             


Asn Leu  Phe Val Met Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser 
    1775                 1780                 1785             


Ile Ala  Ala Arg Gly Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu 
    1790                 1795                 1800             


Ala Ala  Ala Ile Phe Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp 
    1805                 1810                 1815             


Pro Phe  Pro Glu Ser Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu 
    1820                 1825                 1830             


Ile Pro  Asp Arg Ala Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu 
    1835                 1840                 1845             


Tyr Thr  Gly Lys Thr Val Trp  Phe Val Pro Ser Val  Lys Met Gly 
    1850                 1855                 1860             


Asn Glu  Ile Ala Leu Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val 
    1865                 1870                 1875             


Gln Leu  Asn Arg Lys Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys 
    1880                 1885                 1890             


Asn Asp  Asp Trp Asp Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met 
    1895                 1900                 1905             


Gly Ala  Asn Phe Lys Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser 
    1910                 1915                 1920             


Val Lys  Pro Thr Ile Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu 
    1925                 1930                 1935             


Gly Glu  Pro Ser Ala Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg 
    1940                 1945                 1950             


Gly Arg  Ile Gly Arg Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys 
    1955                 1960                 1965             


Tyr Gly  Gly His Thr Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp 
    1970                 1975                 1980             


Thr Glu  Ala Arg Ile Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly 
    1985                 1990                 1995             


Leu Ile  Ala Gln Phe Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr 
    2000                 2005                 2010             


Met Asp  Gly Glu Tyr Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe 
    2015                 2020                 2025             


Leu Glu  Leu Leu Arg Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr 
    2030                 2035                 2040             


Lys Val  Ala Ala Ala Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys 
    2045                 2050                 2055             


Phe Asp  Gly Pro Arg Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu 
    2060                 2065                 2070             


Val Glu  Val Ile Thr Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro 
    2075                 2080                 2085             


Arg Trp  Ile Asp Ala Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys 
    2090                 2095                 2100             


Ala Phe  Lys Asp Phe Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu 
    2105                 2110                 2115             


Ile Glu  Val Leu Gly Lys Met  Pro Glu His Phe Met  Gly Lys Thr 
    2120                 2125                 2130             


Trp Glu  Ala Leu Asp Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys 
    2135                 2140                 2145             


Gly Gly  Arg Ala His Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala 
    2150                 2155                 2160             


Leu Gln  Thr Ile Ala Leu Ile  Ala Leu Leu Ser Val  Met Thr Met 
    2165                 2170                 2175             


Gly Val  Phe Phe Leu Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile 
    2180                 2185                 2190             


Gly Leu  Gly Gly Ala Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp 
    2195                 2200                 2205             


Met Ala  Glu Val Pro Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu 
    2210                 2215                 2220             


Ser Leu  Leu Leu Met Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln 
    2225                 2230                 2235             


Arg Ser  Gln Thr Asp Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val 
    2240                 2245                 2250             


Met Thr  Leu Val Ser Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu 
    2255                 2260                 2265             


Asp Lys  Thr Lys Ser Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile 
    2270                 2275                 2280             


Glu Val  Lys Glu Asn Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu 
    2285                 2290                 2295             


Arg Pro  Ala Thr Ala Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val 
    2300                 2305                 2310             


Leu Thr  Pro Leu Leu Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn 
    2315                 2320                 2325             


Thr Ser  Leu Thr Ser Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr 
    2330                 2335                 2340             


Leu Ala  Arg Gly Phe Pro Phe  Val Asp Val Gly Val  Ser Ala Leu 
    2345                 2350                 2355             


Leu Leu  Ala Ala Gly Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr 
    2360                 2365                 2370             


Val Thr  Ala Ala Thr Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val 
    2375                 2380                 2385             


Pro Gly  Trp Gln Ala Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr 
    2390                 2395                 2400             


Ala Ala  Gly Ile Met Lys Asn  Ala Val Val Asp Gly  Ile Val Ala 
    2405                 2410                 2415             


Thr Asp  Val Pro Glu Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys 
    2420                 2425                 2430             


Lys Val  Gly Gln Ile Met Leu  Ile Leu Val Ser Leu  Ala Ala Val 
    2435                 2440                 2445             


Val Val  Asn Pro Ser Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu 
    2450                 2455                 2460             


Ile Thr  Ala Ala Ala Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser 
    2465                 2470                 2475             


Val Trp  Asn Ala Thr Thr Ala  Ile Gly Leu Cys His  Ile Met Arg 
    2480                 2485                 2490             


Gly Gly  Trp Leu Ser Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys 
    2495                 2500                 2505             


Asn Met  Glu Lys Pro Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg 
    2510                 2515                 2520             


Thr Leu  Gly Glu Val Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys 
    2525                 2530                 2535             


Glu Glu  Phe Thr Arg Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp 
    2540                 2545                 2550             


Arg Ser  Ala Ala Lys His Ala  Arg Lys Glu Gly Asn  Val Thr Gly 
    2555                 2560                 2565             


Gly His  Pro Val Ser Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val 
    2570                 2575                 2580             


Glu Arg  Arg Phe Leu Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly 
    2585                 2590                 2595             


Cys Gly  Arg Gly Gly Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg 
    2600                 2605                 2610             


Val Gln  Glu Val Arg Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu 
    2615                 2620                 2625             


Glu Pro  Gln Leu Val Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met 
    2630                 2635                 2640             


Lys Ser  Gly Val Asp Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp 
    2645                 2650                 2655             


Thr Leu  Leu Cys Asp Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val 
    2660                 2665                 2670             


Glu Glu  His Arg Thr Ile Arg  Val Leu Glu Met Val  Glu Asp Trp 
    2675                 2680                 2685             


Leu His  Arg Gly Pro Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro 
    2690                 2695                 2700             


Tyr Met  Pro Lys Val Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg 
    2705                 2710                 2715             


Tyr Gly  Gly Gly Leu Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr 
    2720                 2725                 2730             


His Glu  Met Tyr Trp Val Ser  Arg Ala Ser Gly Asn  Val Val His 
    2735                 2740                 2745             


Ser Val  Asn Met Thr Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys 
    2750                 2755                 2760             


Arg Thr  Trp Lys Gly Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly 
    2765                 2770                 2775             


Ser Gly  Thr Arg Ala Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr 
    2780                 2785                 2790             


Ser Lys  Ile Lys Asn Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser 
    2795                 2800                 2805             


Ser Thr  Trp His His Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn 
    2810                 2815                 2820             


Tyr His  Gly Ser Tyr Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser 
    2825                 2830                 2835             


Leu Val  Asn Gly Val Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr 
    2840                 2845                 2850             


Ile Thr  Asn Val Thr Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2855                 2860                 2865             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro 
    2870                 2875                 2880             


Glu Pro  Pro Glu Gly Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn 
    2885                 2890                 2895             


Trp Leu  Trp Ala Phe Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys 
    2900                 2905                 2910             


Ser Arg  Glu Glu Phe Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu 
    2915                 2920                 2925             


Gly Ala  Met Phe Glu Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu 
    2930                 2935                 2940             


Ala Val  Glu Asp Pro Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg 
    2945                 2950                 2955             


Glu Ala  His Leu Arg Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met 
    2960                 2965                 2970             


Met Gly  Lys Arg Glu Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys 
    2975                 2980                 2985             


Gly Ser  Arg Ala Ile Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu 
    2990                 2995                 3000             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly 
    3005                 3010                 3015             


Arg Lys  Asn Ser Gly Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys 
    3020                 3025                 3030             


Leu Gly  Tyr Ile Leu Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys 
    3035                 3040                 3045             


Ile Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg 
    3050                 3055                 3060             


Ala Asp  Leu Glu Asn Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly 
    3065                 3070                 3075             


Glu His  Arg Arg Leu Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg 
    3080                 3085                 3090             


His Lys  Val Val Lys Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr 
    3095                 3100                 3105             


Val Met  Asp Val Ile Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln 
    3110                 3115                 3120             


Val Val  Thr Tyr Ala Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln 
    3125                 3130                 3135             


Leu Val  Arg Met Met Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp 
    3140                 3145                 3150             


Val Glu  Lys Leu Thr Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp 
    3155                 3160                 3165             


Leu Phe  Glu Asn Gly Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr 
    3185                 3190                 3195             


Ser Leu  His Phe Leu Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser Asn His Phe  Thr Glu Leu Ile Met  Lys Asp Gly 
    3230                 3235                 3240             


Arg Thr  Leu Val Val Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly 
    3245                 3250                 3255             


Arg Ala  Arg Ile Ser Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ala Val  Pro Val Asn Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Ala Gly Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Glu Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Ile Trp Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg 
    3365                 3370                 3375             


Ala Thr  Trp Ala Glu Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg 
    3380                 3385                 3390             


Ala Ile  Ile Gly Asp Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu 
    3395                 3400                 3405             


Lys Arg  Tyr Glu Asp Thr Thr  Leu Val Glu Asp Thr  Val Leu 
    3410                 3415                 3420         


<210>  13
<211>  10996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  West Nile/Dengue 2 virus chimera with E203 Asn to Asp mutation


<220>
<221>  CDS
<222>  (97)..(10365)

<400>  13
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcg atg tct aag aaa cca gga        114
                                        Met Ser Lys Lys Pro Gly           
                                        1               5                 

ggg ccc ggc aag agc cgg gct gtc aat atg cta aaa cgc gga atg ccc        162
Gly Pro Gly Lys Ser Arg Ala Val Asn Met Leu Lys Arg Gly Met Pro           
            10                  15                  20                    

cgc gtg ttg tcc ttg att gga ctg aag agg gct atg ttg agc ctg atc        210
Arg Val Leu Ser Leu Ile Gly Leu Lys Arg Ala Met Leu Ser Leu Ile           
        25                  30                  35                        

gac ggc aag ggg cca ata cga ttt gtg ttg gct ctc ttg gcg ttc ttc        258
Asp Gly Lys Gly Pro Ile Arg Phe Val Leu Ala Leu Leu Ala Phe Phe           
    40                  45                  50                            

agg ttc aca gca att gct ccg acc cga gca gtg ctg gat cga tgg aga        306
Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala Val Leu Asp Arg Trp Arg           
55                  60                  65                  70            

ggt gtg aac aaa caa aca gcg atg aaa cac ctt ctg agt ttt aag aag        354
Gly Val Asn Lys Gln Thr Ala Met Lys His Leu Leu Ser Phe Lys Lys           
                75                  80                  85                

gaa cta ggg acc ttg acc agt gct atc aat cgg cgg agc tca aaa caa        402
Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn Arg Arg Ser Ser Lys Gln           
            90                  95                  100                   

aag aaa aga tcc gcg ggc atg atc att atg ctg att cca aca gtg atg        450
Lys Lys Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr Val Met           
        105                 110                 115                       

gcg ttc cat tta acc aca cgt aac gga gaa cca cac atg atc gtc agc        498
Ala Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val Ser           
    120                 125                 130                           

aga caa gag aaa ggg aaa agt ctt ctg ttt aaa aca gag gat ggc gtg        546
Arg Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp Gly Val           
135                 140                 145                 150           

aac atg tgt acc ctc atg gcc atg gac ctt ggt gaa ttg tgt gaa gac        594
Asn Met Cys Thr Leu Met Ala Met Asp Leu Gly Glu Leu Cys Glu Asp           
                155                 160                 165               

aca atc acg tac aag tgt ccc ctt ctc agg cag aat gag cca gaa gac        642
Thr Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu Asp           
            170                 175                 180                   

ata gac tgt tgg tgc aac tct acg tcc acg tgg gta act tat ggg acg        690
Ile Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly Thr           
        185                 190                 195                       

tgt acc acc atg gga gaa cat aga aga gaa aaa aga tca gtg gca ctc        738
Cys Thr Thr Met Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala Leu           
    200                 205                 210                           

gtt cca cat gtg gga atg gga ctg gag aca cga act gaa aca tgg atg        786
Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp Met           
215                 220                 225                 230           

tca tca gaa ggg gcc tgg aaa cat gtc cag aga att gaa act tgg atc        834
Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr Trp Ile           
                235                 240                 245               

ttg aga cat cca ggc ttc acc atg atg gca gca atc ctg gca tac acc        882
Leu Arg His Pro Gly Phe Thr Met Met Ala Ala Ile Leu Ala Tyr Thr           
            250                 255                 260                   

ata gga acg aca cat ttc caa aga gcc ctg att ttc atc tta ctg aca        930
Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu Thr           
        265                 270                 275                       

gct gtc act cct tca atg aca atg cgt tgc ata gga atg tca aat aga        978
Ala Val Thr Pro Ser Met Thr Met Arg Cys Ile Gly Met Ser Asn Arg           
    280                 285                 290                           

gac ttt gtg gaa ggg gtt tca gga gga agc tgg gtt gac ata gtc tta       1026
Asp Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile Val Leu           
295                 300                 305                 310           

gaa cat gga agc tgt gtg acg acg atg gca aaa aac aaa cca aca ttg       1074
Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro Thr Leu           
                315                 320                 325               

gat ttt gaa ctg ata aaa aca gaa gcc aaa cag cct gcc acc cta agg       1122
Asp Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr Leu Arg           
            330                 335                 340                   

aag tac tgt ata gag gca aag cta acc aac aca aca aca gaa tct cgc       1170
Lys Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu Ser Arg           
        345                 350                 355                       

tgc cca aca caa ggg gaa ccc agc cta aat gaa gag cag gac aaa agg       1218
Cys Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln Asp Lys Arg           
    360                 365                 370                           

ttc gtc tgc aaa cac tcc atg gta gac aga gga tgg gga aat gga tgt       1266
Phe Val Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn Gly Cys           
375                 380                 385                 390           

gga cta ttt gga aag gga ggc att gtg acc tgt gct atg ttc aga tgc       1314
Gly Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe Arg Cys           
                395                 400                 405               

aaa aag aac atg gaa gga aaa gtt gtg caa cca gaa aac ttg gaa tac       1362
Lys Lys Asn Met Glu Gly Lys Val Val Gln Pro Glu Asn Leu Glu Tyr           
            410                 415                 420                   

acc att gtg ata aca cct cac tca ggg gaa gag cat gca gtc gga aat       1410
Thr Ile Val Ile Thr Pro His Ser Gly Glu Glu His Ala Val Gly Asn           
        425                 430                 435                       

gac aca gga aaa cat ggc aag gaa atc aaa ata aca cca cag agt tcc       1458
Asp Thr Gly Lys His Gly Lys Glu Ile Lys Ile Thr Pro Gln Ser Ser           
    440                 445                 450                           

atc aca gaa gca gaa ttg aca ggt tat ggc act gtc aca atg gag tgc       1506
Ile Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met Glu Cys           
455                 460                 465                 470           

tct cca aga acg ggc ctc gac ttc aat gag atg gtg ttg ttg cag atg       1554
Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu Gln Met           
                475                 480                 485               

gaa gat aaa gct tgg ctg gtg cac agg caa tgg ttc cta gac ctg ccg       1602
Glu Asp Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp Leu Pro           
            490                 495                 500                   

tta cca tgg ttg ccc gga gcg gac aca caa ggg tca aat tgg ata cag       1650
Leu Pro Trp Leu Pro Gly Ala Asp Thr Gln Gly Ser Asn Trp Ile Gln           
        505                 510                 515                       

aaa gag aca ttg gtc act ttc aaa aat ccc cat gcg aag aaa cag gat       1698
Lys Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys Gln Asp           
    520                 525                 530                           

gtt gtt gtt tta gga tcc caa gaa ggg gcc atg cac aca gca ctt aca       1746
Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr           
535                 540                 545                 550           

ggg gcc aca gaa atc caa atg tca tca gga aac tta ctc ttc aca gga       1794
Gly Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe Thr Gly           
                555                 560                 565               

cat ctc aag tgc agg ctg aga atg gac aag cta cag ctc aaa gga atg       1842
His Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys Gly Met           
            570                 575                 580                   

tca tac tct atg tgc aca gga aag ttt aaa gtt gtg aag gaa ata gca       1890
Ser Tyr Ser Met Cys Thr Gly Lys Phe Lys Val Val Lys Glu Ile Ala           
        585                 590                 595                       

gaa aca caa cat gga aca ata gtt atc aga gtg caa tat gaa ggg gac       1938
Glu Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp           
    600                 605                 610                           

ggc tct cca tgc aag atc cct ttt gag ata atg gat ttg gaa aaa aga       1986
Gly Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu Lys Arg           
615                 620                 625                 630           

cat gtc tta ggt cgc ctg att aca gtc aac cca att gtg aca gaa aaa       2034
His Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys           
                635                 640                 645               

gat agc cca gtc aac ata gaa gca gaa cct cca ttc gga gac agc tac       2082
Asp Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr           
            650                 655                 660                   

atc atc ata gga gta gag ccg gga caa ctg aag ctc aac tgg ttt aag       2130
Ile Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe Lys           
        665                 670                 675                       

aaa gga agt tct atc ggc caa atg ttt gag aca aca atg agg ggg gcg       2178
Lys Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg Gly Ala           
    680                 685                 690                           

aag aga atg gcc att tta ggt gac aca gcc tgg gat ttt gga tcc ttg       2226
Lys Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Leu           
695                 700                 705                 710           

gga gga gtg ttt aca tct ata gga aag gct ctc cac caa gtc ttt gga       2274
Gly Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val Phe Gly           
                715                 720                 725               

gca atc tat gga gct gcc ttc agt ggg gtt tca tgg act atg aaa atc       2322
Ala Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met Lys Ile           
            730                 735                 740                   

ctc ata gga gtc att atc aca tgg ata gga atg aat tca cgc agc acc       2370
Leu Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg Ser Thr           
        745                 750                 755                       

tca ctg tct gtg aca cta gta ttg gtg gga att gtg aca ctg tat ttg       2418
Ser Leu Ser Val Thr Leu Val Leu Val Gly Ile Val Thr Leu Tyr Leu           
    760                 765                 770                           

gga gtc atg gtg cag gcc gat tcc gga tgt gcc ata gac atc agc cgg       2466
Gly Val Met Val Gln Ala Asp Ser Gly Cys Ala Ile Asp Ile Ser Arg           
775                 780                 785                 790           

caa gag ctg aga tgt gga agt gga gtg ttc ata cac aat gat gtg gag       2514
Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile His Asn Asp Val Glu           
                795                 800                 805               

gct tgg atg gac cgg tac aag tat tac cct gaa acg cca caa ggc cta       2562
Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu Thr Pro Gln Gly Leu           
            810                 815                 820                   

gcc aag atc att cag aaa gct cat aag gaa gga gtg tgc ggt cta cga       2610
Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly Val Cys Gly Leu Arg           
        825                 830                 835                       

tca gtt tcc aga ctg gag cat caa atg tgg gaa gca gtg aag gac gag       2658
Ser Val Ser Arg Leu Glu His Gln Met Trp Glu Ala Val Lys Asp Glu           
    840                 845                 850                           

ctg aac act ctt ttg aag gag aat ggt gtg gac ctt agt gtc gtg gtt       2706
Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp Leu Ser Val Val Val           
855                 860                 865                 870           

gag aaa cag gag gga atg tac aag tca gca cct aaa cgc ctc acc gcc       2754
Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro Lys Arg Leu Thr Ala           
                875                 880                 885               

acc acg gaa aaa ttg gaa att ggc tgg aag gcc tgg gga aag agt att       2802
Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala Trp Gly Lys Ser Ile           
            890                 895                 900                   

tta ttt gca cca gaa ctc gcc aac aac acc ttt gtg gtt gat ggt ccg       2850
Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe Val Val Asp Gly Pro           
        905                 910                 915                       

gag acc aag gaa tgt ccg act cag aat cgc gct tgg aat agc tta gaa       2898
Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala Trp Asn Ser Leu Glu           
    920                 925                 930                           

gtg gag gat ttt gga ttt ggt ctc acc agc act cgg atg ttc ctg aag       2946
Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr Arg Met Phe Leu Lys           
935                 940                 945                 950           

gtc aga gag agc aac aca act gaa tgt gac tcg aag atc att gga acg       2994
Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser Lys Ile Ile Gly Thr           
                955                 960                 965               

gct gtc aag aac aac ttg gcg atc cac agt gac ctg tcc tat tgg att       3042
Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp Leu Ser Tyr Trp Ile           
            970                 975                 980                   

gaa agc agg ctc aat gat acg tgg aag ctt gaa agg gca gtt ctg ggt       3090
Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu Glu Arg Ala Val Leu Gly           
        985                 990                 995                       

gaa gtc  aaa tca tgt acg tgg  cct gag acg cat acc  ttg tgg ggc        3135
Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr His Thr  Leu Trp Gly            
    1000                 1005                 1010                        

gat gga  atc ctt gag agt gac  ttg ata ata cca gtc  aca ctg gcg        3180
Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile Pro Val  Thr Leu Ala            
    1015                 1020                 1025                        

gga cca  cga agc aat cac aat  cgg aga cct ggg tac  aag aca caa        3225
Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro Gly Tyr  Lys Thr Gln            
    1030                 1035                 1040                        

aac cag  ggc cca tgg gac gaa  ggc cgg gta gag att  gac ttc gat        3270
Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val Glu Ile  Asp Phe Asp            
    1045                 1050                 1055                        

tac tgc  cca gga act acg gtc  acc ctg agt gag agc  tgc gga cac        3315
Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser Glu Ser  Cys Gly His            
    1060                 1065                 1070                        

cgt gga  cct gcc act cgc acc  acc aca gag agc gga  aag ttg ata        3360
Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu Ser Gly  Lys Leu Ile            
    1075                 1080                 1085                        

aca gat  tgg tgc tgc agg agc  tgc acc tta cca cca  ctg cgc tac        3405
Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr            
    1090                 1095                 1100                        

caa act  gac agc ggc tgt tgg  tat ggt atg gag atc  aga cca cag        3450
Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Gln            
    1105                 1110                 1115                        

aga cat  gat gaa aag acc ctc  gtg cag tca caa gtg  aat gct tat        3495
Arg His  Asp Glu Lys Thr Leu  Val Gln Ser Gln Val  Asn Ala Tyr            
    1120                 1125                 1130                        

aat gct  gat atg att gac cct  ttt cag ttg ggc ctt  ctg gtc gtg        3540
Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu Gly Leu  Leu Val Val            
    1135                 1140                 1145                        

ttc ttg  gcc acc cag gag gtc  ctt cgc aag agg tgg  aca gcc aag        3585
Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys Arg Trp  Thr Ala Lys            
    1150                 1155                 1160                        

atc agc  atg cca gct ata ctg  att gct ctg cta gtc  ctg gtg ttt        3630
Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu Leu Val  Leu Val Phe            
    1165                 1170                 1175                        

ggg ggc  att act tac act gat  gtg tta cgc tat gtc  atc ttg gtg        3675
Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg Tyr Val  Ile Leu Val            
    1180                 1185                 1190                        

ggg gca  gct ttc gca gaa tct  aat tcg gga gga gac  gtg gta cac        3720
Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly Gly Asp  Val Val His            
    1195                 1200                 1205                        

ttg gcg  ctc atg gcg acc ttc  aag ata caa cca gtg  ttt atg gtg        3765
Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln Pro Val  Phe Met Val            
    1210                 1215                 1220                        

gca tcg  ttt ctc aaa gcg aga  tgg acc aac cag gag  aac att ttg        3810
Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn Gln Glu  Asn Ile Leu            
    1225                 1230                 1235                        

ttg atg  ttg gcg gct gtt ttc  ttt caa atg gct tat  tac gat gcc        3855
Leu Met  Leu Ala Ala Val Phe  Phe Gln Met Ala Tyr  Tyr Asp Ala            
    1240                 1245                 1250                        

cgc caa  att ctg ctc tgg gag  atc cct gat gtg ttg  aat tca ctg        3900
Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp Val Leu  Asn Ser Leu            
    1255                 1260                 1265                        

gcg gta  gct tgg atg ata ctg  aga gcc ata aca ttc  aca acg aca        3945
Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile Thr Phe  Thr Thr Thr            
    1270                 1275                 1280                        

tca aac  gtg gtt gtt ccg ctg  cta gcc ctg cta aca  ccc ggg ctg        3990
Ser Asn  Val Val Val Pro Leu  Leu Ala Leu Leu Thr  Pro Gly Leu            
    1285                 1290                 1295                        

aga tgc  ttg aat ctg gat gtg  tac agg ata ctg ctg  ttg atg gtc        4035
Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile Leu Leu  Leu Met Val            
    1300                 1305                 1310                        

gga ata  ggc agc ttg atc agg  gag aag agg agt gca  gct gca aaa        4080
Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg Ser Ala  Ala Ala Lys            
    1315                 1320                 1325                        

aag aaa  gga gca agt ctg cta  tgc ttg gct cta gcc  tca aca gga        4125
Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala Leu Ala  Ser Thr Gly            
    1330                 1335                 1340                        

ctt ttc  aac ccc atg atc ctt  gct gct gga ctg att  gca tgt gat        4170
Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly Leu Ile  Ala Cys Asp            
    1345                 1350                 1355                        

ccc aac  cgt aaa cgc gga tgg  ccc gca act gaa gtg  atg aca gct        4215
Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr Glu Val  Met Thr Ala            
    1360                 1365                 1370                        

gtc ggc  cta atg ttt gcc atc  gtc gga ggg ctg gca  gag ctt gac        4260
Val Gly  Leu Met Phe Ala Ile  Val Gly Gly Leu Ala  Glu Leu Asp            
    1375                 1380                 1385                        

att gac  tcc atg gcc att cca  atg act atc gcg ggg  ctc atg ttt        4305
Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile Ala Gly  Leu Met Phe            
    1390                 1395                 1400                        

gct gct  ttc gtg att tct ggg  aaa tca aca gat atg  tgg att gag        4350
Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr Asp Met  Trp Ile Glu            
    1405                 1410                 1415                        

aga acg  gcg gac att tcc tgg  gaa agt gat gca gaa  att aca ggc        4395
Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp Ala Glu  Ile Thr Gly            
    1420                 1425                 1430                        

tcg agc  gaa aga gtt gat gtg  cgg ctt gat gat gat  gga aac ttc        4440
Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp Asp Asp  Gly Asn Phe            
    1435                 1440                 1445                        

cag ctc  atg aat gat cca gga  gca cct tgg aag ata  tgg atg ctc        4485
Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp Lys Ile  Trp Met Leu            
    1450                 1455                 1460                        

aga atg  gtc tgt ctc gcg att  agt gcg tac acc ccc  tgg gca atc        4530
Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr Thr Pro  Trp Ala Ile            
    1465                 1470                 1475                        

ttg ccc  tca gta gtt gga ttt  tgg ata act ctc caa  tac aca aag        4575
Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr Leu Gln  Tyr Thr Lys            
    1480                 1485                 1490                        

aga gga  ggc gtg ttg tgg gac  act ccc tca cca aag  gag tac aaa        4620
Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser Pro Lys  Glu Tyr Lys            
    1495                 1500                 1505                        

aag ggg  gac acg acc acc ggc  gtc tac agg atc atg  act cgt ggg        4665
Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg Ile Met  Thr Arg Gly            
    1510                 1515                 1520                        

ctg ctc  ggc agt tat caa gca  gga gcg ggc gtg atg  gtt gaa ggt        4710
Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly Val Met  Val Glu Gly            
    1525                 1530                 1535                        

gtt ttc  cac acc ctt tgg cat  aca aca aaa gga gcc  gct ttg atg        4755
Val Phe  His Thr Leu Trp His  Thr Thr Lys Gly Ala  Ala Leu Met            
    1540                 1545                 1550                        

agc gga  gag ggc cgc ctg gac  cca tac tgg ggc agt  gtc aag gag        4800
Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp Gly Ser  Val Lys Glu            
    1555                 1560                 1565                        

gat cga  ctt tgt tac gga gga  ccc tgg aaa ttg cag  cac aag tgg        4845
Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys Leu Gln  His Lys Trp            
    1570                 1575                 1580                        

aac ggg  cag gat gag gtg cag  atg att gtg gtg gaa  cct ggc agg        4890
Asn Gly  Gln Asp Glu Val Gln  Met Ile Val Val Glu  Pro Gly Arg            
    1585                 1590                 1595                        

aac gtt  aag aac gtc cag acg  aaa cca ggg gtg ttc  aaa aca cct        4935
Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly Val Phe  Lys Thr Pro            
    1600                 1605                 1610                        

gaa gga  gaa atc ggg gcc gtg  act ttg gac ttc ccc  act gga aca        4980
Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp Phe Pro  Thr Gly Thr            
    1615                 1620                 1625                        

tca ggc  tca cca ata gtg gac  aaa aac ggt gat gtg  att ggg ctt        5025
Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly Asp Val  Ile Gly Leu            
    1630                 1635                 1640                        

tat ggc  aat gga gtc ata atg  ccc aac ggc tca tac  ata agc gcg        5070
Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly Ser Tyr  Ile Ser Ala            
    1645                 1650                 1655                        

ata gtg  cag ggt gaa agg atg  gat gag cca atc cca  gcc gga ttc        5115
Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro Ile Pro  Ala Gly Phe            
    1660                 1665                 1670                        

gaa cct  gag atg ctg agg aaa  aaa cag atc act gta  ctg gat ctc        5160
Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile Thr Val  Leu Asp Leu            
    1675                 1680                 1685                        

cat ccc  ggc gcc ggt aaa aca  agg agg att ctg cca  cag atc atc        5205
His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile Leu Pro  Gln Ile Ile            
    1690                 1695                 1700                        

aaa gag  gcc ata aac aga aga  ctg aga aca gcc gtg  cta gca cca        5250
Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr Ala Val  Leu Ala Pro            
    1705                 1710                 1715                        

acc agg  gtt gtg gct gct gag  atg gct gaa gca ctg  aga gga ctg        5295
Thr Arg  Val Val Ala Ala Glu  Met Ala Glu Ala Leu  Arg Gly Leu            
    1720                 1725                 1730                        

ccc atc  cgg tac cag aca tcc  gca gtg ccc aga gaa  cat aat gga        5340
Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro Arg Glu  His Asn Gly            
    1735                 1740                 1745                        

aat gag  att gtt gat gtc atg  tgt cat gct acc ctc  acc cac agg        5385
Asn Glu  Ile Val Asp Val Met  Cys His Ala Thr Leu  Thr His Arg            
    1750                 1755                 1760                        

ctg atg  tct cct cac agg gtg  ccg aac tac aac ctg  ttc gtg atg        5430
Leu Met  Ser Pro His Arg Val  Pro Asn Tyr Asn Leu  Phe Val Met            
    1765                 1770                 1775                        

gat gag  gct cat ttc acc gac  cca gct agc att gca  gca aga ggt        5475
Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly            
    1780                 1785                 1790                        

tac att  tcc aca aag gtc gag  cta ggg gag gcg gcg  gca ata ttc        5520
Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu Ala Ala  Ala Ile Phe            
    1795                 1800                 1805                        

atg aca  gcc acc cca cca ggc  act tca gat cca ttc  cca gag tcc        5565
Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp Pro Phe  Pro Glu Ser            
    1810                 1815                 1820                        

aat tca  cca att tcc gac tta  cag act gag atc ccg  gat cga gct        5610
Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu Ile Pro  Asp Arg Ala            
    1825                 1830                 1835                        

tgg aac  tct gga tac gaa tgg  atc aca gaa tac acc  ggg aag acg        5655
Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu Tyr Thr  Gly Lys Thr            
    1840                 1845                 1850                        

gtt tgg  ttt gtg cct agt gtc  aag atg ggg aat gag  att gcc ctt        5700
Val Trp  Phe Val Pro Ser Val  Lys Met Gly Asn Glu  Ile Ala Leu            
    1855                 1860                 1865                        

tgc cta  caa cgt gct gga aag  aaa gta gtc caa ttg  aac aga aag        5745
Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val Gln Leu  Asn Arg Lys            
    1870                 1875                 1880                        

tcg tac  gag acg gag tac cca  aaa tgt aag aac gat  gat tgg gac        5790
Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys Asn Asp  Asp Trp Asp            
    1885                 1890                 1895                        

ttt gtt  atc aca aca gac ata  tct gaa atg ggg gct  aac ttc aag        5835
Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys            
    1900                 1905                 1910                        

gcg agc  agg gtg att gac agc  cgg aag agt gtg aaa  cca acc atc        5880
Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser Val Lys  Pro Thr Ile            
    1915                 1920                 1925                        

ata aca  gaa gga gaa ggg aga  gtg atc ctg gga gaa  cca tct gca        5925
Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu Gly Glu  Pro Ser Ala            
    1930                 1935                 1940                        

gtg aca  gca gct agt gcc gcc  cag aga cgt gga cgt  atc ggt aga        5970
Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg            
    1945                 1950                 1955                        

aat ccg  tcg caa gtt ggt gat  gag tac tgt tat ggg  ggg cac acg        6015
Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys Tyr Gly  Gly His Thr            
    1960                 1965                 1970                        

aat gaa  gac gac tcg aac ttc  gcc cat tgg act gag  gca cga atc        6060
Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp Thr Glu  Ala Arg Ile            
    1975                 1980                 1985                        

atg ctg  gac aac atc aac atg  cca aac gga ctg atc  gct caa ttc        6105
Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly Leu Ile  Ala Gln Phe            
    1990                 1995                 2000                        

tac caa  cca gag cgt gag aag  gta tat acc atg gat  ggg gaa tac        6150
Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr Met Asp  Gly Glu Tyr            
    2005                 2010                 2015                        

cgg ctc  aga gga gaa gag aga  aaa aac ttt ctg gaa  ctg ttg agg        6195
Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe Leu Glu  Leu Leu Arg            
    2020                 2025                 2030                        

act gca  gat ctg cca gtt tgg  ctg gct tac aag gtt  gca gcg gct        6240
Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr Lys Val  Ala Ala Ala            
    2035                 2040                 2045                        

gga gtg  tca tac cac gac cgg  agg tgg tgc ttt gat  ggt cct agg        6285
Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys Phe Asp  Gly Pro Arg            
    2050                 2055                 2060                        

aca aac  aca att tta gaa gac  aac aac gaa gtg gaa  gtc atc acg        6330
Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu Val Glu  Val Ile Thr            
    2065                 2070                 2075                        

aag ctt  ggt gaa agg aag att  ctg agg ccg cgc tgg  att gac gcc        6375
Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro Arg Trp  Ile Asp Ala            
    2080                 2085                 2090                        

agg gtg  tac tcg gat cac cag  gca cta aag gcg ttc  aag gac ttc        6420
Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys Ala Phe  Lys Asp Phe            
    2095                 2100                 2105                        

gcc tcg  gga aaa cgt tct cag  ata ggg ctc att gag  gtt ctg gga        6465
Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu Ile Glu  Val Leu Gly            
    2110                 2115                 2120                        

aag atg  cct gag cac ttc atg  ggg aag aca tgg gaa  gca ctt gac        6510
Lys Met  Pro Glu His Phe Met  Gly Lys Thr Trp Glu  Ala Leu Asp            
    2125                 2130                 2135                        

acc atg  tac gtt gtg gcc act  gca gag aaa gga gga  aga gct cac        6555
Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys Gly Gly  Arg Ala His            
    2140                 2145                 2150                        

aga atg  gcc ctg gag gaa ctg  cca gat gct ctt cag  aca att gcc        6600
Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala Leu Gln  Thr Ile Ala            
    2155                 2160                 2165                        

ttg att  gcc tta ttg agt gtg  atg acc atg gga gta  ttc ttc ctc        6645
Leu Ile  Ala Leu Leu Ser Val  Met Thr Met Gly Val  Phe Phe Leu            
    2170                 2175                 2180                        

ctc atg  cag cgg aag ggc att  gga aag ata ggt ttg  gga ggc gct        6690
Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile Gly Leu  Gly Gly Ala            
    2185                 2190                 2195                        

gtc ttg  gga gtc gcg acc ttt  ttc tgt tgg atg gct  gaa gtt cca        6735
Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp Met Ala  Glu Val Pro            
    2200                 2205                 2210                        

gga acg  aag atc gcc gga atg  ttg ctg ctc tcc ctt  ctc ttg atg        6780
Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu Ser Leu  Leu Leu Met            
    2215                 2220                 2225                        

att gtg  cta att cct gag cca  gag aag caa cgt tcg  cag aca gac        6825
Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln Arg Ser  Gln Thr Asp            
    2230                 2235                 2240                        

aac cag  cta gcc gtg ttc ctg  att tgt gtc atg acc  ctt gtg agc        6870
Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val Met Thr  Leu Val Ser            
    2245                 2250                 2255                        

gca gtg  gca gcc aac gag atg  ggt tgg cta gat aag  acc aag agt        6915
Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu Asp Lys  Thr Lys Ser            
    2260                 2265                 2270                        

gac ata  agc agt ttg ttt ggg  caa aga att gag gtc  aag gag aat        6960
Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile Glu Val  Lys Glu Asn            
    2275                 2280                 2285                        

ttc agc  atg gga gag ttt ctt  ttg gac ttg agg cct  gca aca gcc        7005
Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu Arg Pro  Ala Thr Ala            
    2290                 2295                 2300                        

tgg tca  ctg tac gct gtg aca  aca gcg gtc ctc act  cca ctg cta        7050
Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val Leu Thr  Pro Leu Leu            
    2305                 2310                 2315                        

aag cat  ttg atc acg tca gat  tac atc aac acc tca  ttg acc tca        7095
Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn Thr Ser  Leu Thr Ser            
    2320                 2325                 2330                        

ata aac  gtt cag gca agt gca  cta ttc aca ctc gcg  cga ggc ttc        7140
Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr Leu Ala  Arg Gly Phe            
    2335                 2340                 2345                        

ccc ttc  gtc gat gtt gga gtg  tcg gct ctc ctg cta  gca gcc gga        7185
Pro Phe  Val Asp Val Gly Val  Ser Ala Leu Leu Leu  Ala Ala Gly            
    2350                 2355                 2360                        

tgc tgg  gga caa gtc acc ctc  acc gtt acg gta aca  gcg gca aca        7230
Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr Val Thr  Ala Ala Thr            
    2365                 2370                 2375                        

ctc ctt  ttt tgc cac tat gcc  tac atg gtt ccc ggt  tgg caa gct        7275
Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val Pro Gly  Trp Gln Ala            
    2380                 2385                 2390                        

gag gca  atg cgc tca gcc cag  cgg cgg aca gcg gcc  gga atc atg        7320
Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr Ala Ala  Gly Ile Met            
    2395                 2400                 2405                        

aag aac  gct gta gtg gat ggc  atc gtg gcc acg gac  gtc cca gaa        7365
Lys Asn  Ala Val Val Asp Gly  Ile Val Ala Thr Asp  Val Pro Glu            
    2410                 2415                 2420                        

tta gag  cgc acc aca ccc atc  atg cag aag aaa gtt  gga cag atc        7410
Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys Lys Val  Gly Gln Ile            
    2425                 2430                 2435                        

atg ctg  atc ttg gtg tct cta  gct gca gta gta gtg  aac ccg tct        7455
Met Leu  Ile Leu Val Ser Leu  Ala Ala Val Val Val  Asn Pro Ser            
    2440                 2445                 2450                        

gtg aag  aca gta cga gaa gcc  gga att ttg atc acg  gcc gca gcg        7500
Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu Ile Thr  Ala Ala Ala            
    2455                 2460                 2465                        

gtg acg  ctt tgg gag aat gga  gca agc tct gtt tgg  aac gca aca        7545
Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser Val Trp  Asn Ala Thr            
    2470                 2475                 2480                        

act gcc  atc gga ctc tgc cac  atc atg cgt ggg ggt  tgg ttg tca        7590
Thr Ala  Ile Gly Leu Cys His  Ile Met Arg Gly Gly  Trp Leu Ser            
    2485                 2490                 2495                        

tgt cta  tcc ata aca tgg aca  ctc ata aag aac atg  gaa aaa cca        7635
Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys Asn Met  Glu Lys Pro            
    2500                 2505                 2510                        

gga cta  aaa aga ggt ggg gca  aaa gga cgc acc ttg  gga gag gtt        7680
Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg Thr Leu  Gly Glu Val            
    2515                 2520                 2525                        

tgg aaa  gaa aga ctc aac cag  atg aca aaa gaa gag  ttc act agg        7725
Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys Glu Glu  Phe Thr Arg            
    2530                 2535                 2540                        

tac cgc  aaa gag gcc atc atc  gaa gtc gat cgc tca  gcg gca aaa        7770
Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp Arg Ser  Ala Ala Lys            
    2545                 2550                 2555                        

cac gcc  agg aaa gaa ggc aat  gtc act gga ggg cat  cca gtc tct        7815
His Ala  Arg Lys Glu Gly Asn  Val Thr Gly Gly His  Pro Val Ser            
    2560                 2565                 2570                        

agg ggc  aca gca aaa ctg aga  tgg ctg gtc gaa cgg  agg ttt ctc        7860
Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val Glu Arg  Arg Phe Leu            
    2575                 2580                 2585                        

gaa ccg  gtc gga aaa gtg att  gac ctt gga tgt gga  aga ggc ggt        7905
Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly Cys Gly  Arg Gly Gly            
    2590                 2595                 2600                        

tgg tgt  tac tat atg gca acc  caa aaa aga gtc caa  gaa gtc aga        7950
Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg Val Gln  Glu Val Arg            
    2605                 2610                 2615                        

ggg tac  aca aag ggc ggt ccc  gga cat gaa gag ccc  caa cta gtg        7995
Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu Glu Pro  Gln Leu Val            
    2620                 2625                 2630                        

caa agt  tat gga tgg aac att  gtc acc atg aag agt  gga gtg gat        8040
Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met Lys Ser  Gly Val Asp            
    2635                 2640                 2645                        

gtg ttc  tac aga cct tct gag  tgt tgt gac acc ctc  ctt tgt gac        8085
Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp Thr Leu  Leu Cys Asp            
    2650                 2655                 2660                        

atc gga  gag tcc tcg tca agt  gct gag gtt gaa gag  cat agg acg        8130
Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val Glu Glu  His Arg Thr            
    2665                 2670                 2675                        

att cgg  gtc ctt gaa atg gtt  gag gac tgg ctg cac  cga ggg cca        8175
Ile Arg  Val Leu Glu Met Val  Glu Asp Trp Leu His  Arg Gly Pro            
    2680                 2685                 2690                        

agg gaa  ttt tgc gtg aag gtg  ctc tgc ccc tac atg  ccg aaa gtc        8220
Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro Tyr Met  Pro Lys Val            
    2695                 2700                 2705                        

ata gag  aag atg gag ctg ctc  caa cgc cgg tat ggg  ggg gga ctg        8265
Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg Tyr Gly  Gly Gly Leu            
    2710                 2715                 2720                        

gtc aga  aac cca ctc tca cgg  aat tcc acg cac gag  atg tat tgg        8310
Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr His Glu  Met Tyr Trp            
    2725                 2730                 2735                        

gtg agt  cga gct tca ggc aat  gtg gta cat tca gtg  aat atg acc        8355
Val Ser  Arg Ala Ser Gly Asn  Val Val His Ser Val  Asn Met Thr            
    2740                 2745                 2750                        

agc cag  gtg ctc cta gga aga  atg gaa aaa agg acc  tgg aag gga        8400
Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys Arg Thr  Trp Lys Gly            
    2755                 2760                 2765                        

ccc caa  tac gag gaa gat gta  aac ttg gga agt gga  acc agg gcg        8445
Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly Ser Gly  Thr Arg Ala            
    2770                 2775                 2780                        

gtg gga  aaa ccc ctg ctc aac  tca gac acc agt aaa  atc aag aac        8490
Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr Ser Lys  Ile Lys Asn            
    2785                 2790                 2795                        

agg att  gaa cga ctc agg cgt  gag tac agt tcg acg  tgg cac cac        8535
Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser Ser Thr  Trp His His            
    2800                 2805                 2810                        

gat gag  aac cac cca tat aga  acc tgg aac tat cac  ggc agt tat        8580
Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn Tyr His  Gly Ser Tyr            
    2815                 2820                 2825                        

gat gtg  aag ccc aca ggc tcc  gcc agt tcg ctg gtc  aat gga gtg        8625
Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser Leu Val  Asn Gly Val            
    2830                 2835                 2840                        

gtc agg  ctc ctc tca aaa cca  tgg gac acc atc acg  aat gtt acc        8670
Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr Ile Thr  Asn Val Thr            
    2845                 2850                 2855                        

acc atg  gcc atg act gac act  act ccc ttc ggg cag  cag cga gtg        8715
Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe Gly Gln  Gln Arg Val            
    2860                 2865                 2870                        

ttc aaa  gag aag gtg gac acg  aaa gct cct gaa ccg  cca gaa gga        8760
Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro Glu Pro  Pro Glu Gly            
    2875                 2880                 2885                        

gtg aag  tac gtg ctc aac gag  acc acc aac tgg ttg  tgg gcg ttt        8805
Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn Trp Leu  Trp Ala Phe            
    2890                 2895                 2900                        

ttg gcc  aga gaa aaa cgt ccc  aga atg tgc tct cga  gag gaa ttc        8850
Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys Ser Arg  Glu Glu Phe            
    2905                 2910                 2915                        

ata aga  aag gtc aac agc aat  gca gct ttg ggt gcc  atg ttt gaa        8895
Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu Gly Ala  Met Phe Glu            
    2920                 2925                 2930                        

gag cag  aat caa tgg agg agc  gcc aga gaa gca gtt  gaa gat cca        8940
Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu Ala Val  Glu Asp Pro            
    2935                 2940                 2945                        

aaa ttt  tgg gag atg gtg gat  gag gag cgc gag gca  cat ctg cgg        8985
Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg Glu Ala  His Leu Arg            
    2950                 2955                 2960                        

ggg gaa  tgt cac act tgc att  tac aac atg atg gga  aag aga gag        9030
Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met Met Gly  Lys Arg Glu            
    2965                 2970                 2975                        

aaa aaa  ccc gga gag ttc gga  aag gcc aag gga agc  aga gcc att        9075
Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys Gly Ser  Arg Ala Ile            
    2980                 2985                 2990                        

tgg ttc  atg tgg ctc gga gct  cgc ttt ctg gag ttc  gag gct ctg        9120
Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu Glu Phe  Glu Ala Leu            
    2995                 3000                 3005                        

ggt ttt  ctc aat gaa gac cac  tgg ctt gga aga aag  aac tca gga        9165
Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly Arg Lys  Asn Ser Gly            
    3010                 3015                 3020                        

gga ggt  gtc gag ggc ttg ggc  ctc caa aaa ctg ggt  tac atc ctg        9210
Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys Leu Gly  Tyr Ile Leu            
    3025                 3030                 3035                        

cgt gaa  gtt ggc acc cgg cct  ggg ggc aag atc tat  gct gat gac        9255
Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys Ile Tyr  Ala Asp Asp            
    3040                 3045                 3050                        

aca gct  ggc tgg gac acc cgc  atc acg aga gct gac  ttg gaa aat        9300
Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg Ala Asp  Leu Glu Asn            
    3055                 3060                 3065                        

gaa gct  aag gtg ctt gag ctg  ctt gat ggg gaa cat  cgg cgt ctt        9345
Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly Glu His  Arg Arg Leu            
    3070                 3075                 3080                        

gcc agg  gcc atc att gag ctc  acc tat cgt cac aaa  gtt gtg aaa        9390
Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg His Lys  Val Val Lys            
    3085                 3090                 3095                        

gtg atg  cgc ccg gct gct gat  gga aga acc gtc atg  gat gtt atc        9435
Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr Val Met  Asp Val Ile            
    3100                 3105                 3110                        

tcc aga  gaa gat cag agg ggg  agt gga caa gtt gtc  acc tac gcc        9480
Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln Val Val  Thr Tyr Ala            
    3115                 3120                 3125                        

cta aac  act ttc acc aac ctg  gcc gtc cag ctg gtg  agg atg atg        9525
Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln Leu Val  Arg Met Met            
    3130                 3135                 3140                        

gaa ggg  gaa gga gtg att ggc  cca gat gat gtg gag  aaa ctc aca        9570
Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp Val Glu  Lys Leu Thr            
    3145                 3150                 3155                        

aaa ggg  aaa gga ccc aaa gtc  agg acc tgg ctg ttt  gag aat ggg        9615
Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp Leu Phe  Glu Asn Gly            
    3160                 3165                 3170                        

gaa gaa  aga ctc agc cgc atg  gct gtc agt gga gat  gac tgt gtg        9660
Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser Gly Asp  Asp Cys Val            
    3175                 3180                 3185                        

gta aag  ccc ctg gac gat cgc  ttt gcc acc tcg ctc  cac ttc ctc        9705
Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr Ser Leu  His Phe Leu            
    3190                 3195                 3200                        

aat gct  atg tca aag gtt cgc  aaa gac atc caa gag  tgg aaa ccg        9750
Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile Gln Glu  Trp Lys Pro            
    3205                 3210                 3215                        

tca act  gga tgg tat gat tgg  cag cag gtt cca ttt  tgc tca aac        9795
Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val Pro Phe  Cys Ser Asn            
    3220                 3225                 3230                        

cat ttc  act gaa ttg atc atg  aaa gat gga aga aca  ctg gtg gtt        9840
His Phe  Thr Glu Leu Ile Met  Lys Asp Gly Arg Thr  Leu Val Val            
    3235                 3240                 3245                        

cca tgc  cga gga cag gat gaa  ttg gta ggc aga gct  cgc ata tct        9885
Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly Arg Ala  Arg Ile Ser            
    3250                 3255                 3260                        

cca ggg  gcc gga tgg aac gtc  cgc gac act gct tgt  ctg gct aag        9930
Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr Ala Cys  Leu Ala Lys            
    3265                 3270                 3275                        

tct tat  gcc cag atg tgg ctg  ctt ctg tac ttc cac  aga aga gac        9975
Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr Phe His  Arg Arg Asp            
    3280                 3285                 3290                        

ctg cgg  ctc atg gcc aac gcc  att tgc tcc gct gtc  cct gtg aat       10020
Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser Ala Val  Pro Val Asn            
    3295                 3300                 3305                        

tgg gtc  cct acc gga aga acc  acg tgg tcc atc cat  gca gga gga       10065
Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser Ile His  Ala Gly Gly            
    3310                 3315                 3320                        

gag tgg  atg aca aca gag gac  atg ttg gag gtc tgg  aac cgt gtt       10110
Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu Val Trp  Asn Arg Val            
    3325                 3330                 3335                        

tgg ata  gag gag aat gaa tgg  atg gaa gac aaa acc  cca gtg gag       10155
Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp Lys Thr  Pro Val Glu            
    3340                 3345                 3350                        

aaa tgg  agt gac gtc cca tat  tca gga aaa cga gag  gac atc tgg       10200
Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys Arg Glu  Asp Ile Trp            
    3355                 3360                 3365                        

tgt ggc  agc ctg att ggc aca  aga gcc cga gcc acg  tgg gca gaa       10245
Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg Ala Thr  Trp Ala Glu            
    3370                 3375                 3380                        

aac atc  cag gtg gct atc aac  caa gtc aga gca atc  atc gga gat       10290
Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg Ala Ile  Ile Gly Asp            
    3385                 3390                 3395                        

gag aag  tat gtg gat tac atg  agt tca cta aag aga  tat gaa gac       10335
Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu Lys Arg  Tyr Glu Asp            
    3400                 3405                 3410                        

aca act  ttg gtt gag gac aca  gta ctg tag atatttaatc aattgtaaat      10385
Thr Thr  Leu Val Glu Asp Thr  Val Leu                                     
    3415                 3420                                             

agacaatata agtatgcata aaagtgtagt tttatagtag tatttagtgg tgttagtgta    10445

aatagttaag aaaattttga ggagaaagtc aggccgggaa gttcccgcca ccggaagttg    10505

agtagacggt gctgcctgcg actcaacccc aggaggactg ggtgaacaaa gccgcgaagt    10565

gatccatgta agccctcaga accgtctcgg aaggaggacc ccacatgttg taacttcaaa    10625

gcccaatgtc agaccacgct acggcgtgct actctgcgga gagtgcagtc tgcgatagtg    10685

ccccaggagg actgggttaa caaaggcaaa ccaacgcccc acgcggccct agccccggta    10745

atggtgttaa ccagggcgaa aggactagag gttagaggag accccgcggt ttaaagtgca    10805

cggcccagcc tggctgaagc tgtaggtcag gggaaggact agaggttagt ggagaccccg    10865

tgccacaaaa caccacaaca aaacagcata ttgacacctg ggatagacta ggagatcttc    10925

tgctctgcac aaccagccac acggcacagt gcgccgacaa tggtggctgg tggtgcgaga    10985

acacaggatc t                                                         10996


<210>  14
<211>  3422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Ser Ala Gly Met Ile Ile Met 
            100                 105                 110         


Leu Ile Pro Thr Val Met Ala Phe His Leu Thr Thr Arg Asn Gly Glu 
        115                 120                 125             


Pro His Met Ile Val Ser Arg Gln Glu Lys Gly Lys Ser Leu Leu Phe 
    130                 135                 140                 


Lys Thr Glu Asp Gly Val Asn Met Cys Thr Leu Met Ala Met Asp Leu 
145                 150                 155                 160 


Gly Glu Leu Cys Glu Asp Thr Ile Thr Tyr Lys Cys Pro Leu Leu Arg 
                165                 170                 175     


Gln Asn Glu Pro Glu Asp Ile Asp Cys Trp Cys Asn Ser Thr Ser Thr 
            180                 185                 190         


Trp Val Thr Tyr Gly Thr Cys Thr Thr Met Gly Glu His Arg Arg Glu 
        195                 200                 205             


Lys Arg Ser Val Ala Leu Val Pro His Val Gly Met Gly Leu Glu Thr 
    210                 215                 220                 


Arg Thr Glu Thr Trp Met Ser Ser Glu Gly Ala Trp Lys His Val Gln 
225                 230                 235                 240 


Arg Ile Glu Thr Trp Ile Leu Arg His Pro Gly Phe Thr Met Met Ala 
                245                 250                 255     


Ala Ile Leu Ala Tyr Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu 
            260                 265                 270         


Ile Phe Ile Leu Leu Thr Ala Val Thr Pro Ser Met Thr Met Arg Cys 
        275                 280                 285             


Ile Gly Met Ser Asn Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ser 
    290                 295                 300                 


Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr Thr Met Ala 
305                 310                 315                 320 


Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr Glu Ala Lys 
                325                 330                 335     


Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys Leu Thr Asn 
            340                 345                 350         


Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro Ser Leu Asn 
        355                 360                 365             


Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met Val Asp Arg 
    370                 375                 380                 


Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly Ile Val Thr 
385                 390                 395                 400 


Cys Ala Met Phe Arg Cys Lys Lys Asn Met Glu Gly Lys Val Val Gln 
                405                 410                 415     


Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His Ser Gly Glu 
            420                 425                 430         


Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys Glu Ile Lys 
        435                 440                 445             


Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr Gly Tyr Gly 
    450                 455                 460                 


Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu 
465                 470                 475                 480 


Met Val Leu Leu Gln Met Glu Asp Lys Ala Trp Leu Val His Arg Gln 
                485                 490                 495     


Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala Asp Thr Gln 
            500                 505                 510         


Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe Lys Asn Pro 
        515                 520                 525             


His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln Glu Gly Ala 
    530                 535                 540                 


Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met Ser Ser Gly 
545                 550                 555                 560 


Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg Met Asp Lys 
                565                 570                 575     


Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly Lys Phe Lys 
            580                 585                 590         


Val Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile Val Ile Arg 
        595                 600                 605             


Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro Phe Glu Ile 
    610                 615                 620                 


Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile Thr Val Asn 
625                 630                 635                 640 


Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu Ala Glu Pro 
                645                 650                 655     


Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro Gly Gln Leu 
            660                 665                 670         


Lys Leu Asn Trp Phe Lys Lys Gly Ser Ser Ile Gly Gln Met Phe Glu 
        675                 680                 685             


Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile Leu Gly Asp Thr Ala 
    690                 695                 700                 


Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr Ser Ile Gly Lys Ala 
705                 710                 715                 720 


Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala Ala Phe Ser Gly Val 
                725                 730                 735     


Ser Trp Thr Met Lys Ile Leu Ile Gly Val Ile Ile Thr Trp Ile Gly 
            740                 745                 750         


Met Asn Ser Arg Ser Thr Ser Leu Ser Val Thr Leu Val Leu Val Gly 
        755                 760                 765             


Ile Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala Asp Ser Gly Cys 
    770                 775                 780                 


Ala Ile Asp Ile Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe 
785                 790                 795                 800 


Ile His Asn Asp Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro 
                805                 810                 815     


Glu Thr Pro Gln Gly Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu 
            820                 825                 830         


Gly Val Cys Gly Leu Arg Ser Val Ser Arg Leu Glu His Gln Met Trp 
        835                 840                 845             


Glu Ala Val Lys Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val 
    850                 855                 860                 


Asp Leu Ser Val Val Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala 
865                 870                 875                 880 


Pro Lys Arg Leu Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys 
                885                 890                 895     


Ala Trp Gly Lys Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr 
            900                 905                 910         


Phe Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg 
        915                 920                 925             


Ala Trp Asn Ser Leu Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser 
    930                 935                 940                 


Thr Arg Met Phe Leu Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp 
945                 950                 955                 960 


Ser Lys Ile Ile Gly Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser 
                965                 970                 975     


Asp Leu Ser Tyr Trp Ile Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu 
            980                 985                 990         


Glu Arg Ala Val Leu Gly Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr 
        995                 1000                 1005             


His Thr  Leu Trp Gly Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile 
    1010                 1015                 1020             


Pro Val  Thr Leu Ala Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro 
    1025                 1030                 1035             


Gly Tyr  Lys Thr Gln Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val 
    1040                 1045                 1050             


Glu Ile  Asp Phe Asp Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser 
    1055                 1060                 1065             


Glu Ser  Cys Gly His Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu 
    1070                 1075                 1080             


Ser Gly  Lys Leu Ile Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu 
    1085                 1090                 1095             


Pro Pro  Leu Arg Tyr Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met 
    1100                 1105                 1110             


Glu Ile  Arg Pro Gln Arg His  Asp Glu Lys Thr Leu  Val Gln Ser 
    1115                 1120                 1125             


Gln Val  Asn Ala Tyr Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu 
    1130                 1135                 1140             


Gly Leu  Leu Val Val Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys 
    1145                 1150                 1155             


Arg Trp  Thr Ala Lys Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu 
    1160                 1165                 1170             


Leu Val  Leu Val Phe Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg 
    1175                 1180                 1185             


Tyr Val  Ile Leu Val Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly 
    1190                 1195                 1200             


Gly Asp  Val Val His Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln 
    1205                 1210                 1215             


Pro Val  Phe Met Val Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn 
    1220                 1225                 1230             


Gln Glu  Asn Ile Leu Leu Met  Leu Ala Ala Val Phe  Phe Gln Met 
    1235                 1240                 1245             


Ala Tyr  Tyr Asp Ala Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp 
    1250                 1255                 1260             


Val Leu  Asn Ser Leu Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile 
    1265                 1270                 1275             


Thr Phe  Thr Thr Thr Ser Asn  Val Val Val Pro Leu  Leu Ala Leu 
    1280                 1285                 1290             


Leu Thr  Pro Gly Leu Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile 
    1295                 1300                 1305             


Leu Leu  Leu Met Val Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg 
    1310                 1315                 1320             


Ser Ala  Ala Ala Lys Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala 
    1325                 1330                 1335             


Leu Ala  Ser Thr Gly Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly 
    1340                 1345                 1350             


Leu Ile  Ala Cys Asp Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr 
    1355                 1360                 1365             


Glu Val  Met Thr Ala Val Gly  Leu Met Phe Ala Ile  Val Gly Gly 
    1370                 1375                 1380             


Leu Ala  Glu Leu Asp Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile 
    1385                 1390                 1395             


Ala Gly  Leu Met Phe Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr 
    1400                 1405                 1410             


Asp Met  Trp Ile Glu Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp 
    1415                 1420                 1425             


Ala Glu  Ile Thr Gly Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp 
    1430                 1435                 1440             


Asp Asp  Gly Asn Phe Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp 
    1445                 1450                 1455             


Lys Ile  Trp Met Leu Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr 
    1460                 1465                 1470             


Thr Pro  Trp Ala Ile Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr 
    1475                 1480                 1485             


Leu Gln  Tyr Thr Lys Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser 
    1490                 1495                 1500             


Pro Lys  Glu Tyr Lys Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg 
    1505                 1510                 1515             


Ile Met  Thr Arg Gly Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly 
    1520                 1525                 1530             


Val Met  Val Glu Gly Val Phe  His Thr Leu Trp His  Thr Thr Lys 
    1535                 1540                 1545             


Gly Ala  Ala Leu Met Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp 
    1550                 1555                 1560             


Gly Ser  Val Lys Glu Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys 
    1565                 1570                 1575             


Leu Gln  His Lys Trp Asn Gly  Gln Asp Glu Val Gln  Met Ile Val 
    1580                 1585                 1590             


Val Glu  Pro Gly Arg Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly 
    1595                 1600                 1605             


Val Phe  Lys Thr Pro Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp 
    1610                 1615                 1620             


Phe Pro  Thr Gly Thr Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly 
    1625                 1630                 1635             


Asp Val  Ile Gly Leu Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly 
    1640                 1645                 1650             


Ser Tyr  Ile Ser Ala Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro 
    1655                 1660                 1665             


Ile Pro  Ala Gly Phe Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile 
    1670                 1675                 1680             


Thr Val  Leu Asp Leu His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile 
    1685                 1690                 1695             


Leu Pro  Gln Ile Ile Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr 
    1700                 1705                 1710             


Ala Val  Leu Ala Pro Thr Arg  Val Val Ala Ala Glu  Met Ala Glu 
    1715                 1720                 1725             


Ala Leu  Arg Gly Leu Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro 
    1730                 1735                 1740             


Arg Glu  His Asn Gly Asn Glu  Ile Val Asp Val Met  Cys His Ala 
    1745                 1750                 1755             


Thr Leu  Thr His Arg Leu Met  Ser Pro His Arg Val  Pro Asn Tyr 
    1760                 1765                 1770             


Asn Leu  Phe Val Met Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser 
    1775                 1780                 1785             


Ile Ala  Ala Arg Gly Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu 
    1790                 1795                 1800             


Ala Ala  Ala Ile Phe Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp 
    1805                 1810                 1815             


Pro Phe  Pro Glu Ser Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu 
    1820                 1825                 1830             


Ile Pro  Asp Arg Ala Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu 
    1835                 1840                 1845             


Tyr Thr  Gly Lys Thr Val Trp  Phe Val Pro Ser Val  Lys Met Gly 
    1850                 1855                 1860             


Asn Glu  Ile Ala Leu Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val 
    1865                 1870                 1875             


Gln Leu  Asn Arg Lys Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys 
    1880                 1885                 1890             


Asn Asp  Asp Trp Asp Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met 
    1895                 1900                 1905             


Gly Ala  Asn Phe Lys Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser 
    1910                 1915                 1920             


Val Lys  Pro Thr Ile Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu 
    1925                 1930                 1935             


Gly Glu  Pro Ser Ala Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg 
    1940                 1945                 1950             


Gly Arg  Ile Gly Arg Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys 
    1955                 1960                 1965             


Tyr Gly  Gly His Thr Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp 
    1970                 1975                 1980             


Thr Glu  Ala Arg Ile Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly 
    1985                 1990                 1995             


Leu Ile  Ala Gln Phe Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr 
    2000                 2005                 2010             


Met Asp  Gly Glu Tyr Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe 
    2015                 2020                 2025             


Leu Glu  Leu Leu Arg Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr 
    2030                 2035                 2040             


Lys Val  Ala Ala Ala Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys 
    2045                 2050                 2055             


Phe Asp  Gly Pro Arg Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu 
    2060                 2065                 2070             


Val Glu  Val Ile Thr Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro 
    2075                 2080                 2085             


Arg Trp  Ile Asp Ala Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys 
    2090                 2095                 2100             


Ala Phe  Lys Asp Phe Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu 
    2105                 2110                 2115             


Ile Glu  Val Leu Gly Lys Met  Pro Glu His Phe Met  Gly Lys Thr 
    2120                 2125                 2130             


Trp Glu  Ala Leu Asp Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys 
    2135                 2140                 2145             


Gly Gly  Arg Ala His Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala 
    2150                 2155                 2160             


Leu Gln  Thr Ile Ala Leu Ile  Ala Leu Leu Ser Val  Met Thr Met 
    2165                 2170                 2175             


Gly Val  Phe Phe Leu Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile 
    2180                 2185                 2190             


Gly Leu  Gly Gly Ala Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp 
    2195                 2200                 2205             


Met Ala  Glu Val Pro Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu 
    2210                 2215                 2220             


Ser Leu  Leu Leu Met Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln 
    2225                 2230                 2235             


Arg Ser  Gln Thr Asp Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val 
    2240                 2245                 2250             


Met Thr  Leu Val Ser Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu 
    2255                 2260                 2265             


Asp Lys  Thr Lys Ser Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile 
    2270                 2275                 2280             


Glu Val  Lys Glu Asn Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu 
    2285                 2290                 2295             


Arg Pro  Ala Thr Ala Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val 
    2300                 2305                 2310             


Leu Thr  Pro Leu Leu Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn 
    2315                 2320                 2325             


Thr Ser  Leu Thr Ser Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr 
    2330                 2335                 2340             


Leu Ala  Arg Gly Phe Pro Phe  Val Asp Val Gly Val  Ser Ala Leu 
    2345                 2350                 2355             


Leu Leu  Ala Ala Gly Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr 
    2360                 2365                 2370             


Val Thr  Ala Ala Thr Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val 
    2375                 2380                 2385             


Pro Gly  Trp Gln Ala Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr 
    2390                 2395                 2400             


Ala Ala  Gly Ile Met Lys Asn  Ala Val Val Asp Gly  Ile Val Ala 
    2405                 2410                 2415             


Thr Asp  Val Pro Glu Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys 
    2420                 2425                 2430             


Lys Val  Gly Gln Ile Met Leu  Ile Leu Val Ser Leu  Ala Ala Val 
    2435                 2440                 2445             


Val Val  Asn Pro Ser Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu 
    2450                 2455                 2460             


Ile Thr  Ala Ala Ala Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser 
    2465                 2470                 2475             


Val Trp  Asn Ala Thr Thr Ala  Ile Gly Leu Cys His  Ile Met Arg 
    2480                 2485                 2490             


Gly Gly  Trp Leu Ser Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys 
    2495                 2500                 2505             


Asn Met  Glu Lys Pro Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg 
    2510                 2515                 2520             


Thr Leu  Gly Glu Val Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys 
    2525                 2530                 2535             


Glu Glu  Phe Thr Arg Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp 
    2540                 2545                 2550             


Arg Ser  Ala Ala Lys His Ala  Arg Lys Glu Gly Asn  Val Thr Gly 
    2555                 2560                 2565             


Gly His  Pro Val Ser Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val 
    2570                 2575                 2580             


Glu Arg  Arg Phe Leu Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly 
    2585                 2590                 2595             


Cys Gly  Arg Gly Gly Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg 
    2600                 2605                 2610             


Val Gln  Glu Val Arg Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu 
    2615                 2620                 2625             


Glu Pro  Gln Leu Val Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met 
    2630                 2635                 2640             


Lys Ser  Gly Val Asp Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp 
    2645                 2650                 2655             


Thr Leu  Leu Cys Asp Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val 
    2660                 2665                 2670             


Glu Glu  His Arg Thr Ile Arg  Val Leu Glu Met Val  Glu Asp Trp 
    2675                 2680                 2685             


Leu His  Arg Gly Pro Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro 
    2690                 2695                 2700             


Tyr Met  Pro Lys Val Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg 
    2705                 2710                 2715             


Tyr Gly  Gly Gly Leu Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr 
    2720                 2725                 2730             


His Glu  Met Tyr Trp Val Ser  Arg Ala Ser Gly Asn  Val Val His 
    2735                 2740                 2745             


Ser Val  Asn Met Thr Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys 
    2750                 2755                 2760             


Arg Thr  Trp Lys Gly Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly 
    2765                 2770                 2775             


Ser Gly  Thr Arg Ala Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr 
    2780                 2785                 2790             


Ser Lys  Ile Lys Asn Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser 
    2795                 2800                 2805             


Ser Thr  Trp His His Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn 
    2810                 2815                 2820             


Tyr His  Gly Ser Tyr Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser 
    2825                 2830                 2835             


Leu Val  Asn Gly Val Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr 
    2840                 2845                 2850             


Ile Thr  Asn Val Thr Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2855                 2860                 2865             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro 
    2870                 2875                 2880             


Glu Pro  Pro Glu Gly Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn 
    2885                 2890                 2895             


Trp Leu  Trp Ala Phe Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys 
    2900                 2905                 2910             


Ser Arg  Glu Glu Phe Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu 
    2915                 2920                 2925             


Gly Ala  Met Phe Glu Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu 
    2930                 2935                 2940             


Ala Val  Glu Asp Pro Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg 
    2945                 2950                 2955             


Glu Ala  His Leu Arg Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met 
    2960                 2965                 2970             


Met Gly  Lys Arg Glu Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys 
    2975                 2980                 2985             


Gly Ser  Arg Ala Ile Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu 
    2990                 2995                 3000             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly 
    3005                 3010                 3015             


Arg Lys  Asn Ser Gly Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys 
    3020                 3025                 3030             


Leu Gly  Tyr Ile Leu Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys 
    3035                 3040                 3045             


Ile Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg 
    3050                 3055                 3060             


Ala Asp  Leu Glu Asn Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly 
    3065                 3070                 3075             


Glu His  Arg Arg Leu Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg 
    3080                 3085                 3090             


His Lys  Val Val Lys Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr 
    3095                 3100                 3105             


Val Met  Asp Val Ile Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln 
    3110                 3115                 3120             


Val Val  Thr Tyr Ala Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln 
    3125                 3130                 3135             


Leu Val  Arg Met Met Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp 
    3140                 3145                 3150             


Val Glu  Lys Leu Thr Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp 
    3155                 3160                 3165             


Leu Phe  Glu Asn Gly Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr 
    3185                 3190                 3195             


Ser Leu  His Phe Leu Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser Asn His Phe  Thr Glu Leu Ile Met  Lys Asp Gly 
    3230                 3235                 3240             


Arg Thr  Leu Val Val Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly 
    3245                 3250                 3255             


Arg Ala  Arg Ile Ser Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ala Val  Pro Val Asn Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Ala Gly Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Glu Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Ile Trp Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg 
    3365                 3370                 3375             


Ala Thr  Trp Ala Glu Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg 
    3380                 3385                 3390             


Ala Ile  Ile Gly Asp Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu 
    3395                 3400                 3405             


Lys Arg  Tyr Glu Asp Thr Thr  Leu Val Glu Asp Thr  Val Leu 
    3410                 3415                 3420         


<210>  15
<211>  11002
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WN/DEN3 chimera with E345 His to Leu mutation (BE345)


<220>
<221>  CDS
<222>  (97)..(10371)

<400>  15
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcg atg tct aag aaa cca gga        114
                                        Met Ser Lys Lys Pro Gly           
                                        1               5                 

ggg ccc ggc aag agc cgg gct gtc aat atg cta aaa cgc gga atg ccc        162
Gly Pro Gly Lys Ser Arg Ala Val Asn Met Leu Lys Arg Gly Met Pro           
            10                  15                  20                    

cgc gtg ttg tcc ttg att gga ctg aag agg gct atg ttg agc ctg atc        210
Arg Val Leu Ser Leu Ile Gly Leu Lys Arg Ala Met Leu Ser Leu Ile           
        25                  30                  35                        

gac ggc aag ggg cca ata cga ttt gtg ttg gct ctc ttg gcg ttc ttc        258
Asp Gly Lys Gly Pro Ile Arg Phe Val Leu Ala Leu Leu Ala Phe Phe           
    40                  45                  50                            

agg ttc aca gca att gct ccg acc cga gca gtg ctg gat cga tgg aga        306
Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala Val Leu Asp Arg Trp Arg           
55                  60                  65                  70            

ggt gtg aac aaa caa aca gcg atg aaa cac ctt ctg agt ttt aag aag        354
Gly Val Asn Lys Gln Thr Ala Met Lys His Leu Leu Ser Phe Lys Lys           
                75                  80                  85                

gaa cta ggg acc ttg acc agt gct atc aat cgg cgg agt tcg aaa caa        402
Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn Arg Arg Ser Ser Lys Gln           
            90                  95                  100                   

aag aaa aga gga gga aag acc gga att ctc tgt ctc atg atg atg tta        450
Lys Lys Arg Gly Gly Lys Thr Gly Ile Leu Cys Leu Met Met Met Leu           
        105                 110                 115                       

cca gca aca ctt gct ttc cac tta act tca cga gat gga gag ccg cgc        498
Pro Ala Thr Leu Ala Phe His Leu Thr Ser Arg Asp Gly Glu Pro Arg           
    120                 125                 130                           

atg att gtg ggg aag aat gaa aga gga aaa tcc cta ctt ttc aag aca        546
Met Ile Val Gly Lys Asn Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr           
135                 140                 145                 150           

gcc tct gga atc aac atg tgc aca ctc ata gcc atg gat ctg gga gag        594
Ala Ser Gly Ile Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu           
                155                 160                 165               

atg tgt gat gac acg gtc act tac aaa tgc ccc cac att acc gaa gtg        642
Met Cys Asp Asp Thr Val Thr Tyr Lys Cys Pro His Ile Thr Glu Val           
            170                 175                 180                   

gag cct gaa gac att gac tgc tgg tgc aac ctt aca tcg aca tgg gtg        690
Glu Pro Glu Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val           
        185                 190                 195                       

act tat gga aca tgc aat caa gct gga gag cat aga cgc gat aag aga        738
Thr Tyr Gly Thr Cys Asn Gln Ala Gly Glu His Arg Arg Asp Lys Arg           
    200                 205                 210                           

tca gtg gcg tta gct ccc cat gtt ggc atg gga ctg gac aca cgc act        786
Ser Val Ala Leu Ala Pro His Val Gly Met Gly Leu Asp Thr Arg Thr           
215                 220                 225                 230           

caa acc tgg atg tcg gct gaa gga gct tgg aga caa gtc gag aag gta        834
Gln Thr Trp Met Ser Ala Glu Gly Ala Trp Arg Gln Val Glu Lys Val           
                235                 240                 245               

gag aca tgg gcc ctt agg cac cca ggg ttt acc ata cta gcc cta ttt        882
Glu Thr Trp Ala Leu Arg His Pro Gly Phe Thr Ile Leu Ala Leu Phe           
            250                 255                 260                   

ctt gcc cat tac ata ggc act tcc ttg acc cag aaa gtg gtt att ttt        930
Leu Ala His Tyr Ile Gly Thr Ser Leu Thr Gln Lys Val Val Ile Phe           
        265                 270                 275                       

ata cta tta atg ctg gtt acc cca tcc atg aca atg aga tgt gta gga        978
Ile Leu Leu Met Leu Val Thr Pro Ser Met Thr Met Arg Cys Val Gly           
    280                 285                 290                           

gta gga aac aga gat ttt gtg gaa ggc cta tcg gga gct acg tgg gtt       1026
Val Gly Asn Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val           
295                 300                 305                 310           

gac gtg gtg ctc gag cac ggt ggg tgt gtg act acc atg gct aag aac       1074
Asp Val Val Leu Glu His Gly Gly Cys Val Thr Thr Met Ala Lys Asn           
                315                 320                 325               

aag ccc acg ctg gac ata gag ctt cag aag acc gag gcc acc caa ctg       1122
Lys Pro Thr Leu Asp Ile Glu Leu Gln Lys Thr Glu Ala Thr Gln Leu           
            330                 335                 340                   

gcg acc cta agg aag cta tgc att gag gga aaa att acc aac ata aca       1170
Ala Thr Leu Arg Lys Leu Cys Ile Glu Gly Lys Ile Thr Asn Ile Thr           
        345                 350                 355                       

acc gac tca aga tgt ccc acc caa ggg gaa gcg att tta cct gag gag       1218
Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Ile Leu Pro Glu Glu           
    360                 365                 370                           

cag gac cag aac tac gtg tgt aag cat aca tac gtg gac aga ggc tgg       1266
Gln Asp Gln Asn Tyr Val Cys Lys His Thr Tyr Val Asp Arg Gly Trp           
375                 380                 385                 390           

gga aac ggt tgt ggt ttg ttt ggc aag gga agc ttg gtg aca tgc gcg       1314
Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala           
                395                 400                 405               

aaa ttt caa tgt tta gaa tca ata gag gga aaa gtg gtg caa cat gag       1362
Lys Phe Gln Cys Leu Glu Ser Ile Glu Gly Lys Val Val Gln His Glu           
            410                 415                 420                   

aac ctc aaa tac acc gtc atc atc aca gtg cac aca gga gac caa cac       1410
Asn Leu Lys Tyr Thr Val Ile Ile Thr Val His Thr Gly Asp Gln His           
        425                 430                 435                       

cag gtg gga aat gaa acg cag gga gtc acg gct gag ata aca ccc cag       1458
Gln Val Gly Asn Glu Thr Gln Gly Val Thr Ala Glu Ile Thr Pro Gln           
    440                 445                 450                           

gca tca acc gct gaa gcc att tta cct gaa tat gga acc ctc ggg cta       1506
Ala Ser Thr Ala Glu Ala Ile Leu Pro Glu Tyr Gly Thr Leu Gly Leu           
455                 460                 465                 470           

gaa tgc tca cca cgg aca ggt ttg gat ttc aat gaa atg atc tca ttg       1554
Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Ile Ser Leu           
                475                 480                 485               

aca atg aag aac aaa gca tgg atg gta cat aga caa tgg ttc ttt gac       1602
Thr Met Lys Asn Lys Ala Trp Met Val His Arg Gln Trp Phe Phe Asp           
            490                 495                 500                   

tta ccc cta cca tgg aca tca gga gct aca gca gaa aca cca act tgg       1650
Leu Pro Leu Pro Trp Thr Ser Gly Ala Thr Ala Glu Thr Pro Thr Trp           
        505                 510                 515                       

aac agg aaa gag ctt ctt gtg aca ttt aaa aat gca cat gca aaa aag       1698
Asn Arg Lys Glu Leu Leu Val Thr Phe Lys Asn Ala His Ala Lys Lys           
    520                 525                 530                           

caa gaa gta gtt gtt ctt gga tca caa gag gga gca atg cat aca gca       1746
Gln Glu Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala           
535                 540                 545                 550           

ctg aca gga gct aca gag atc caa acc tca gga ggc aca agt atc ttt       1794
Leu Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly Gly Thr Ser Ile Phe           
                555                 560                 565               

gcg ggg cac tta aaa tgt aga ctc aag atg gac aaa ttg gaa ctc aag       1842
Ala Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Glu Leu Lys           
            570                 575                 580                   

ggg atg agc tat gca atg tgc ttg agt agc ttt gtg ttg aag aaa gaa       1890
Gly Met Ser Tyr Ala Met Cys Leu Ser Ser Phe Val Leu Lys Lys Glu           
        585                 590                 595                       

gtc tcc gaa acg cag cat ggg aca ata ctc att aag gtt gag tac aaa       1938
Val Ser Glu Thr Gln His Gly Thr Ile Leu Ile Lys Val Glu Tyr Lys           
    600                 605                 610                           

ggg gaa gat gca ccc tgc aag att cct ttc tcc acg gag gat gga caa       1986
Gly Glu Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Glu Asp Gly Gln           
615                 620                 625                 630           

gga aaa gct ctc aat ggc aga ctg atc aca gcc aat cca gtg gtg acc       2034
Gly Lys Ala Leu Asn Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr           
                635                 640                 645               

aag aag gag gag cct gtc aac att gag gct gaa cct cct ttt gga gaa       2082
Lys Lys Glu Glu Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu           
            650                 655                 660                   

agt aac ata gta att gga att gga gac aaa gcc ctg aaa atc aac tgg       2130
Ser Asn Ile Val Ile Gly Ile Gly Asp Lys Ala Leu Lys Ile Asn Trp           
        665                 670                 675                       

tac aag aag gga agc tcg att ggg aag atg ttc gag gcc act gcc aga       2178
Tyr Lys Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg           
    680                 685                 690                           

ggt gca agg cgc atg gcc atc ttg gga gac aca gcc tgg gac ttt gga       2226
Gly Ala Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly           
695                 700                 705                 710           

tca gtg ggt ggt gtt ttg aat tca tta ggg aaa atg gtc cac caa ata       2274
Ser Val Gly Gly Val Leu Asn Ser Leu Gly Lys Met Val His Gln Ile           
                715                 720                 725               

ttt ggg agt gct tac aca gcc cta ttt ggt gga gtc tcc tgg atg atg       2322
Phe Gly Ser Ala Tyr Thr Ala Leu Phe Gly Gly Val Ser Trp Met Met           
            730                 735                 740                   

aaa att gga ata ggt gtc ctc tta acc tgg ata ggg ttg aac tca aaa       2370
Lys Ile Gly Ile Gly Val Leu Leu Thr Trp Ile Gly Leu Asn Ser Lys           
        745                 750                 755                       

aat act tct atg tca ttt tca tgc atc gcg ata gga atc att aca ctc       2418
Asn Thr Ser Met Ser Phe Ser Cys Ile Ala Ile Gly Ile Ile Thr Leu           
    760                 765                 770                           

tat ctg gga gcc gtg gtg caa gct gac tcc gga tgt gcc ata gac atc       2466
Tyr Leu Gly Ala Val Val Gln Ala Asp Ser Gly Cys Ala Ile Asp Ile           
775                 780                 785                 790           

agc cgg caa gag ctg aga tgt gga agt gga gtg ttc ata cac aat gat       2514
Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile His Asn Asp           
                795                 800                 805               

gtg gag gct tgg atg gac cgg tac aag tat tac cct gaa acg cca caa       2562
Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu Thr Pro Gln           
            810                 815                 820                   

ggc cta gcc aag atc att cag aaa gct cat aag gaa gga gtg tgc ggt       2610
Gly Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly Val Cys Gly           
        825                 830                 835                       

cta cga tca gtt tcc aga ctg gag cat caa atg tgg gaa gca gtg aag       2658
Leu Arg Ser Val Ser Arg Leu Glu His Gln Met Trp Glu Ala Val Lys           
    840                 845                 850                           

gac gag ctg aac act ctt ttg aag gag aat ggt gtg gac ctt agt gtc       2706
Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp Leu Ser Val           
855                 860                 865                 870           

gtg gtt gag aaa cag gag gga atg tac aag tca gca cct aaa cgc ctc       2754
Val Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro Lys Arg Leu           
                875                 880                 885               

acc gcc acc acg gaa aaa ttg gaa att ggc tgg aag gcc tgg gga aag       2802
Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala Trp Gly Lys           
            890                 895                 900                   

agt att tta ttt gca cca gaa ctc gcc aac aac acc ttt gtg gtt gat       2850
Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe Val Val Asp           
        905                 910                 915                       

ggt ccg gag acc aag gaa tgt ccg act cag aat cgc gct tgg aat agc       2898
Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala Trp Asn Ser           
    920                 925                 930                           

tta gaa gtg gag gat ttt gga ttt ggt ctc acc agc act cgg atg ttc       2946
Leu Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr Arg Met Phe           
935                 940                 945                 950           

ctg aag gtc aga gag agc aac aca act gaa tgt gac tcg aag atc att       2994
Leu Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser Lys Ile Ile           
                955                 960                 965               

gga acg gct gtc aag aac aac ttg gcg atc cac agt gac ctg tcc tat       3042
Gly Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp Leu Ser Tyr           
            970                 975                 980                   

tgg att gaa agc agg ctc aat gat acg tgg aag ctt gaa agg gca gtt       3090
Trp Ile Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu Glu Arg Ala Val           
        985                 990                 995                       

ctg ggt  gaa gtc aaa tca tgt  acg tgg cct gag acg  cat acc ttg        3135
Leu Gly  Glu Val Lys Ser Cys  Thr Trp Pro Glu Thr  His Thr Leu            
    1000                 1005                 1010                        

tgg ggc  gat gga atc ctt gag  agt gac ttg ata ata  cca gtc aca        3180
Trp Gly  Asp Gly Ile Leu Glu  Ser Asp Leu Ile Ile  Pro Val Thr            
    1015                 1020                 1025                        

ctg gcg  gga cca cga agc aat  cac aat cgg aga cct  ggg tac aag        3225
Leu Ala  Gly Pro Arg Ser Asn  His Asn Arg Arg Pro  Gly Tyr Lys            
    1030                 1035                 1040                        

aca caa  aac cag ggc cca tgg  gac gaa ggc cgg gta  gag att gac        3270
Thr Gln  Asn Gln Gly Pro Trp  Asp Glu Gly Arg Val  Glu Ile Asp            
    1045                 1050                 1055                        

ttc gat  tac tgc cca gga act  acg gtc acc ctg agt  gag agc tgc        3315
Phe Asp  Tyr Cys Pro Gly Thr  Thr Val Thr Leu Ser  Glu Ser Cys            
    1060                 1065                 1070                        

gga cac  cgt gga cct gcc act  cgc acc acc aca gag  agc gga aag        3360
Gly His  Arg Gly Pro Ala Thr  Arg Thr Thr Thr Glu  Ser Gly Lys            
    1075                 1080                 1085                        

ttg ata  aca gat tgg tgc tgc  agg agc tgc acc tta  cca cca ctg        3405
Leu Ile  Thr Asp Trp Cys Cys  Arg Ser Cys Thr Leu  Pro Pro Leu            
    1090                 1095                 1100                        

cgc tac  caa act gac agc ggc  tgt tgg tat ggt atg  gag atc aga        3450
Arg Tyr  Gln Thr Asp Ser Gly  Cys Trp Tyr Gly Met  Glu Ile Arg            
    1105                 1110                 1115                        

cca cag  aga cat gat gaa aag  acc ctc gtg cag tca  caa gtg aat        3495
Pro Gln  Arg His Asp Glu Lys  Thr Leu Val Gln Ser  Gln Val Asn            
    1120                 1125                 1130                        

gct tat  aat gct gat atg att  gac cct ttt cag ttg  ggc ctt ctg        3540
Ala Tyr  Asn Ala Asp Met Ile  Asp Pro Phe Gln Leu  Gly Leu Leu            
    1135                 1140                 1145                        

gtc gtg  ttc ttg gcc acc cag  gag gtc ctt cgc aag  agg tgg aca        3585
Val Val  Phe Leu Ala Thr Gln  Glu Val Leu Arg Lys  Arg Trp Thr            
    1150                 1155                 1160                        

gcc aag  atc agc atg cca gct  ata ctg att gct ctg  cta gtc ctg        3630
Ala Lys  Ile Ser Met Pro Ala  Ile Leu Ile Ala Leu  Leu Val Leu            
    1165                 1170                 1175                        

gtg ttt  ggg ggc att act tac  act gat gtg tta cgc  tat gtc atc        3675
Val Phe  Gly Gly Ile Thr Tyr  Thr Asp Val Leu Arg  Tyr Val Ile            
    1180                 1185                 1190                        

ttg gtg  ggg gca gct ttc gca  gaa tct aat tcg gga  gga gac gtg        3720
Leu Val  Gly Ala Ala Phe Ala  Glu Ser Asn Ser Gly  Gly Asp Val            
    1195                 1200                 1205                        

gta cac  ttg gcg ctc atg gcg  acc ttc aag ata caa  cca gtg ttt        3765
Val His  Leu Ala Leu Met Ala  Thr Phe Lys Ile Gln  Pro Val Phe            
    1210                 1215                 1220                        

atg gtg  gca tcg ttt ctc aaa  gcg aga tgg acc aac  cag gag aac        3810
Met Val  Ala Ser Phe Leu Lys  Ala Arg Trp Thr Asn  Gln Glu Asn            
    1225                 1230                 1235                        

att ttg  ttg atg ttg gcg gct  gtt ttc ttt caa atg  gct tat tac        3855
Ile Leu  Leu Met Leu Ala Ala  Val Phe Phe Gln Met  Ala Tyr Tyr            
    1240                 1245                 1250                        

gat gcc  cgc caa att ctg ctc  tgg gag atc cct gat  gtg ttg aat        3900
Asp Ala  Arg Gln Ile Leu Leu  Trp Glu Ile Pro Asp  Val Leu Asn            
    1255                 1260                 1265                        

tca ctg  gcg gta gct tgg atg  ata ctg aga gcc ata  aca ttc aca        3945
Ser Leu  Ala Val Ala Trp Met  Ile Leu Arg Ala Ile  Thr Phe Thr            
    1270                 1275                 1280                        

acg aca  tca aac gtg gtt gtt  ccg ctg cta gcc ctg  cta aca ccc        3990
Thr Thr  Ser Asn Val Val Val  Pro Leu Leu Ala Leu  Leu Thr Pro            
    1285                 1290                 1295                        

ggg ctg  aga tgc ttg aat ctg  gat gtg tac agg ata  ctg ctg ttg        4035
Gly Leu  Arg Cys Leu Asn Leu  Asp Val Tyr Arg Ile  Leu Leu Leu            
    1300                 1305                 1310                        

atg gtc  gga ata ggc agc ttg  atc agg gag aag agg  agt gca gct        4080
Met Val  Gly Ile Gly Ser Leu  Ile Arg Glu Lys Arg  Ser Ala Ala            
    1315                 1320                 1325                        

gca aaa  aag aaa gga gca agt  ctg cta tgc ttg gct  cta gcc tca        4125
Ala Lys  Lys Lys Gly Ala Ser  Leu Leu Cys Leu Ala  Leu Ala Ser            
    1330                 1335                 1340                        

aca gga  ctt ttc aac ccc atg  atc ctt gct gct gga  ctg att gca        4170
Thr Gly  Leu Phe Asn Pro Met  Ile Leu Ala Ala Gly  Leu Ile Ala            
    1345                 1350                 1355                        

tgt gat  ccc aac cgt aaa cgc  gga tgg ccc gca act  gaa gtg atg        4215
Cys Asp  Pro Asn Arg Lys Arg  Gly Trp Pro Ala Thr  Glu Val Met            
    1360                 1365                 1370                        

aca gct  gtc ggc cta atg ttt  gcc atc gtc gga ggg  ctg gca gag        4260
Thr Ala  Val Gly Leu Met Phe  Ala Ile Val Gly Gly  Leu Ala Glu            
    1375                 1380                 1385                        

ctt gac  att gac tcc atg gcc  att cca atg act atc  gcg ggg ctc        4305
Leu Asp  Ile Asp Ser Met Ala  Ile Pro Met Thr Ile  Ala Gly Leu            
    1390                 1395                 1400                        

atg ttt  gct gct ttc gtg att  tct ggg aaa tca aca  gat atg tgg        4350
Met Phe  Ala Ala Phe Val Ile  Ser Gly Lys Ser Thr  Asp Met Trp            
    1405                 1410                 1415                        

att gag  aga acg gcg gac att  tcc tgg gaa agt gat  gca gaa att        4395
Ile Glu  Arg Thr Ala Asp Ile  Ser Trp Glu Ser Asp  Ala Glu Ile            
    1420                 1425                 1430                        

aca ggc  tcg agc gaa aga gtt  gat gtg cgg ctt gat  gat gat gga        4440
Thr Gly  Ser Ser Glu Arg Val  Asp Val Arg Leu Asp  Asp Asp Gly            
    1435                 1440                 1445                        

aac ttc  cag ctc atg aat gat  cca gga gca cct tgg  aag ata tgg        4485
Asn Phe  Gln Leu Met Asn Asp  Pro Gly Ala Pro Trp  Lys Ile Trp            
    1450                 1455                 1460                        

atg ctc  aga atg gtc tgt ctc  gcg att agt gcg tac  acc ccc tgg        4530
Met Leu  Arg Met Val Cys Leu  Ala Ile Ser Ala Tyr  Thr Pro Trp            
    1465                 1470                 1475                        

gca atc  ttg ccc tca gta gtt  gga ttt tgg ata act  ctc caa tac        4575
Ala Ile  Leu Pro Ser Val Val  Gly Phe Trp Ile Thr  Leu Gln Tyr            
    1480                 1485                 1490                        

aca aag  aga gga ggc gtg ttg  tgg gac act ccc tca  cca aag gag        4620
Thr Lys  Arg Gly Gly Val Leu  Trp Asp Thr Pro Ser  Pro Lys Glu            
    1495                 1500                 1505                        

tac aaa  aag ggg gac acg acc  acc ggc gtc tac agg  atc atg act        4665
Tyr Lys  Lys Gly Asp Thr Thr  Thr Gly Val Tyr Arg  Ile Met Thr            
    1510                 1515                 1520                        

cgt ggg  ctg ctc ggc agt tat  caa gca gga gcg ggc  gtg atg gtt        4710
Arg Gly  Leu Leu Gly Ser Tyr  Gln Ala Gly Ala Gly  Val Met Val            
    1525                 1530                 1535                        

gaa ggt  gtt ttc cac acc ctt  tgg cat aca aca aaa  gga gcc gct        4755
Glu Gly  Val Phe His Thr Leu  Trp His Thr Thr Lys  Gly Ala Ala            
    1540                 1545                 1550                        

ttg atg  agc gga gag ggc cgc  ctg gac cca tac tgg  ggc agt gtc        4800
Leu Met  Ser Gly Glu Gly Arg  Leu Asp Pro Tyr Trp  Gly Ser Val            
    1555                 1560                 1565                        

aag gag  gat cga ctt tgt tac  gga gga ccc tgg aaa  ttg cag cac        4845
Lys Glu  Asp Arg Leu Cys Tyr  Gly Gly Pro Trp Lys  Leu Gln His            
    1570                 1575                 1580                        

aag tgg  aac ggg cag gat gag  gtg cag atg att gtg  gtg gaa cct        4890
Lys Trp  Asn Gly Gln Asp Glu  Val Gln Met Ile Val  Val Glu Pro            
    1585                 1590                 1595                        

ggc agg  aac gtt aag aac gtc  cag acg aaa cca ggg  gtg ttc aaa        4935
Gly Arg  Asn Val Lys Asn Val  Gln Thr Lys Pro Gly  Val Phe Lys            
    1600                 1605                 1610                        

aca cct  gaa gga gaa atc ggg  gcc gtg act ttg gac  ttc ccc act        4980
Thr Pro  Glu Gly Glu Ile Gly  Ala Val Thr Leu Asp  Phe Pro Thr            
    1615                 1620                 1625                        

gga aca  tca ggc tca cca ata  gtg gac aaa aac ggt  gat gtg att        5025
Gly Thr  Ser Gly Ser Pro Ile  Val Asp Lys Asn Gly  Asp Val Ile            
    1630                 1635                 1640                        

ggg ctt  tat ggc aat gga gtc  ata atg ccc aac ggc  tca tac ata        5070
Gly Leu  Tyr Gly Asn Gly Val  Ile Met Pro Asn Gly  Ser Tyr Ile            
    1645                 1650                 1655                        

agc gcg  ata gtg cag ggt gaa  agg atg gat gag cca  atc cca gcc        5115
Ser Ala  Ile Val Gln Gly Glu  Arg Met Asp Glu Pro  Ile Pro Ala            
    1660                 1665                 1670                        

gga ttc  gaa cct gag atg ctg  agg aaa aaa cag atc  act gta ctg        5160
Gly Phe  Glu Pro Glu Met Leu  Arg Lys Lys Gln Ile  Thr Val Leu            
    1675                 1680                 1685                        

gat ctc  cat ccc ggc gcc ggt  aaa aca agg agg att  ctg cca cag        5205
Asp Leu  His Pro Gly Ala Gly  Lys Thr Arg Arg Ile  Leu Pro Gln            
    1690                 1695                 1700                        

atc atc  aaa gag gcc ata aac  aga aga ctg aga aca  gcc gtg cta        5250
Ile Ile  Lys Glu Ala Ile Asn  Arg Arg Leu Arg Thr  Ala Val Leu            
    1705                 1710                 1715                        

gca cca  acc agg gtt gtg gct  gct gag atg gct gaa  gca ctg aga        5295
Ala Pro  Thr Arg Val Val Ala  Ala Glu Met Ala Glu  Ala Leu Arg            
    1720                 1725                 1730                        

gga ctg  ccc atc cgg tac cag  aca tcc gca gtg ccc  aga gaa cat        5340
Gly Leu  Pro Ile Arg Tyr Gln  Thr Ser Ala Val Pro  Arg Glu His            
    1735                 1740                 1745                        

aat gga  aat gag att gtt gat  gtc atg tgt cat gct  acc ctc acc        5385
Asn Gly  Asn Glu Ile Val Asp  Val Met Cys His Ala  Thr Leu Thr            
    1750                 1755                 1760                        

cac agg  ctg atg tct cct cac  agg gtg ccg aac tac  aac ctg ttc        5430
His Arg  Leu Met Ser Pro His  Arg Val Pro Asn Tyr  Asn Leu Phe            
    1765                 1770                 1775                        

gtg atg  gat gag gct cat ttc  acc gac cca gct agc  att gca gca        5475
Val Met  Asp Glu Ala His Phe  Thr Asp Pro Ala Ser  Ile Ala Ala            
    1780                 1785                 1790                        

aga ggt  tac att tcc aca aag  gtc gag cta ggg gag  gcg gcg gca        5520
Arg Gly  Tyr Ile Ser Thr Lys  Val Glu Leu Gly Glu  Ala Ala Ala            
    1795                 1800                 1805                        

ata ttc  atg aca gcc acc cca  cca ggc act tca gat  cca ttc cca        5565
Ile Phe  Met Thr Ala Thr Pro  Pro Gly Thr Ser Asp  Pro Phe Pro            
    1810                 1815                 1820                        

gag tcc  aat tca cca att tcc  gac tta cag act gag  atc ccg gat        5610
Glu Ser  Asn Ser Pro Ile Ser  Asp Leu Gln Thr Glu  Ile Pro Asp            
    1825                 1830                 1835                        

cga gct  tgg aac tct gga tac  gaa tgg atc aca gaa  tac acc ggg        5655
Arg Ala  Trp Asn Ser Gly Tyr  Glu Trp Ile Thr Glu  Tyr Thr Gly            
    1840                 1845                 1850                        

aag acg  gtt tgg ttt gtg cct  agt gtc aag atg ggg  aat gag att        5700
Lys Thr  Val Trp Phe Val Pro  Ser Val Lys Met Gly  Asn Glu Ile            
    1855                 1860                 1865                        

gcc ctt  tgc cta caa cgt gct  gga aag aaa gta gtc  caa ttg aac        5745
Ala Leu  Cys Leu Gln Arg Ala  Gly Lys Lys Val Val  Gln Leu Asn            
    1870                 1875                 1880                        

aga aag  tcg tac gag acg gag  tac cca aaa tgt aag  aac gat gat        5790
Arg Lys  Ser Tyr Glu Thr Glu  Tyr Pro Lys Cys Lys  Asn Asp Asp            
    1885                 1890                 1895                        

tgg gac  ttt gtt atc aca aca  gac ata tct gaa atg  ggg gct aac        5835
Trp Asp  Phe Val Ile Thr Thr  Asp Ile Ser Glu Met  Gly Ala Asn            
    1900                 1905                 1910                        

ttc aag  gcg agc agg gtg att  gac agc cgg aag agt  gtg aaa cca        5880
Phe Lys  Ala Ser Arg Val Ile  Asp Ser Arg Lys Ser  Val Lys Pro            
    1915                 1920                 1925                        

acc atc  ata aca gaa gga gaa  ggg aga gtg atc ctg  gga gaa cca        5925
Thr Ile  Ile Thr Glu Gly Glu  Gly Arg Val Ile Leu  Gly Glu Pro            
    1930                 1935                 1940                        

tct gca  gtg aca gca gct agt  gcc gcc cag aga cgt  gga cgt atc        5970
Ser Ala  Val Thr Ala Ala Ser  Ala Ala Gln Arg Arg  Gly Arg Ile            
    1945                 1950                 1955                        

ggt aga  aat ccg tcg caa gtt  ggt gat gag tac tgt  tat ggg ggg        6015
Gly Arg  Asn Pro Ser Gln Val  Gly Asp Glu Tyr Cys  Tyr Gly Gly            
    1960                 1965                 1970                        

cac acg  aat gaa gac gac tcg  aac ttc gcc cat tgg  act gag gca        6060
His Thr  Asn Glu Asp Asp Ser  Asn Phe Ala His Trp  Thr Glu Ala            
    1975                 1980                 1985                        

cga atc  atg ctg gac aac atc  aac atg cca aac gga  ctg atc gct        6105
Arg Ile  Met Leu Asp Asn Ile  Asn Met Pro Asn Gly  Leu Ile Ala            
    1990                 1995                 2000                        

caa ttc  tac caa cca gag cgt  gag aag gta tat acc  atg gat ggg        6150
Gln Phe  Tyr Gln Pro Glu Arg  Glu Lys Val Tyr Thr  Met Asp Gly            
    2005                 2010                 2015                        

gaa tac  cgg ctc aga gga gaa  gag aga aaa aac ttt  ctg gaa ctg        6195
Glu Tyr  Arg Leu Arg Gly Glu  Glu Arg Lys Asn Phe  Leu Glu Leu            
    2020                 2025                 2030                        

ttg agg  act gca gat ctg cca  gtt tgg ctg gct tac  aag gtt gca        6240
Leu Arg  Thr Ala Asp Leu Pro  Val Trp Leu Ala Tyr  Lys Val Ala            
    2035                 2040                 2045                        

gcg gct  gga gtg tca tac cac  gac cgg agg tgg tgc  ttt gat ggt        6285
Ala Ala  Gly Val Ser Tyr His  Asp Arg Arg Trp Cys  Phe Asp Gly            
    2050                 2055                 2060                        

cct agg  aca aac aca att tta  gaa gac aac aac gaa  gtg gaa gtc        6330
Pro Arg  Thr Asn Thr Ile Leu  Glu Asp Asn Asn Glu  Val Glu Val            
    2065                 2070                 2075                        

atc acg  aag ctt ggt gaa agg  aag att ctg agg ccg  cgc tgg att        6375
Ile Thr  Lys Leu Gly Glu Arg  Lys Ile Leu Arg Pro  Arg Trp Ile            
    2080                 2085                 2090                        

gac gcc  agg gtg tac tcg gat  cac cag gca cta aag  gcg ttc aag        6420
Asp Ala  Arg Val Tyr Ser Asp  His Gln Ala Leu Lys  Ala Phe Lys            
    2095                 2100                 2105                        

gac ttc  gcc tcg gga aaa cgt  tct cag ata ggg ctc  att gag gtt        6465
Asp Phe  Ala Ser Gly Lys Arg  Ser Gln Ile Gly Leu  Ile Glu Val            
    2110                 2115                 2120                        

ctg gga  aag atg cct gag cac  ttc atg ggg aag aca  tgg gaa gca        6510
Leu Gly  Lys Met Pro Glu His  Phe Met Gly Lys Thr  Trp Glu Ala            
    2125                 2130                 2135                        

ctt gac  acc atg tac gtt gtg  gcc act gca gag aaa  gga gga aga        6555
Leu Asp  Thr Met Tyr Val Val  Ala Thr Ala Glu Lys  Gly Gly Arg            
    2140                 2145                 2150                        

gct cac  aga atg gcc ctg gag  gaa ctg cca gat gct  ctt cag aca        6600
Ala His  Arg Met Ala Leu Glu  Glu Leu Pro Asp Ala  Leu Gln Thr            
    2155                 2160                 2165                        

att gcc  ttg att gcc tta ttg  agt gtg atg acc atg  gga gta ttc        6645
Ile Ala  Leu Ile Ala Leu Leu  Ser Val Met Thr Met  Gly Val Phe            
    2170                 2175                 2180                        

ttc ctc  ctc atg cag cgg aag  ggc att gga aag ata  ggt ttg gga        6690
Phe Leu  Leu Met Gln Arg Lys  Gly Ile Gly Lys Ile  Gly Leu Gly            
    2185                 2190                 2195                        

ggc gct  gtc ttg gga gtc gcg  acc ttt ttc tgt tgg  atg gct gaa        6735
Gly Ala  Val Leu Gly Val Ala  Thr Phe Phe Cys Trp  Met Ala Glu            
    2200                 2205                 2210                        

gtt cca  gga acg aag atc gcc  gga atg ttg ctg ctc  tcc ctt ctc        6780
Val Pro  Gly Thr Lys Ile Ala  Gly Met Leu Leu Leu  Ser Leu Leu            
    2215                 2220                 2225                        

ttg atg  att gtg cta att cct  gag cca gag aag caa  cgt tcg cag        6825
Leu Met  Ile Val Leu Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Gln            
    2230                 2235                 2240                        

aca gac  aac cag cta gcc gtg  ttc ctg att tgt gtc  atg acc ctt        6870
Thr Asp  Asn Gln Leu Ala Val  Phe Leu Ile Cys Val  Met Thr Leu            
    2245                 2250                 2255                        

gtg agc  gca gtg gca gcc aac  gag atg ggt tgg cta  gat aag acc        6915
Val Ser  Ala Val Ala Ala Asn  Glu Met Gly Trp Leu  Asp Lys Thr            
    2260                 2265                 2270                        

aag agt  gac ata agc agt ttg  ttt ggg caa aga att  gag gtc aag        6960
Lys Ser  Asp Ile Ser Ser Leu  Phe Gly Gln Arg Ile  Glu Val Lys            
    2275                 2280                 2285                        

gag aat  ttc agc atg gga gag  ttt ctt ttg gac ttg  agg cct gca        7005
Glu Asn  Phe Ser Met Gly Glu  Phe Leu Leu Asp Leu  Arg Pro Ala            
    2290                 2295                 2300                        

aca gcc  tgg tca ctg tac gct  gtg aca aca gcg gtc  ctc act cca        7050
Thr Ala  Trp Ser Leu Tyr Ala  Val Thr Thr Ala Val  Leu Thr Pro            
    2305                 2310                 2315                        

ctg cta  aag cat ttg atc acg  tca gat tac atc aac  acc tca ttg        7095
Leu Leu  Lys His Leu Ile Thr  Ser Asp Tyr Ile Asn  Thr Ser Leu            
    2320                 2325                 2330                        

acc tca  ata aac gtt cag gca  agt gca cta ttc aca  ctc gcg cga        7140
Thr Ser  Ile Asn Val Gln Ala  Ser Ala Leu Phe Thr  Leu Ala Arg            
    2335                 2340                 2345                        

ggc ttc  ccc ttc gtc gat gtt  gga gtg tcg gct ctc  ctg cta gca        7185
Gly Phe  Pro Phe Val Asp Val  Gly Val Ser Ala Leu  Leu Leu Ala            
    2350                 2355                 2360                        

gcc gga  tgc tgg gga caa gtc  acc ctc acc gtt acg  gta aca gcg        7230
Ala Gly  Cys Trp Gly Gln Val  Thr Leu Thr Val Thr  Val Thr Ala            
    2365                 2370                 2375                        

gca aca  ctc ctt ttt tgc cac  tat gcc tac atg gtt  ccc ggt tgg        7275
Ala Thr  Leu Leu Phe Cys His  Tyr Ala Tyr Met Val  Pro Gly Trp            
    2380                 2385                 2390                        

caa gct  gag gca atg cgc tca  gcc cag cgg cgg aca  gcg gcc gga        7320
Gln Ala  Glu Ala Met Arg Ser  Ala Gln Arg Arg Thr  Ala Ala Gly            
    2395                 2400                 2405                        

atc atg  aag aac gct gta gtg  gat ggc atc gtg gcc  acg gac gtc        7365
Ile Met  Lys Asn Ala Val Val  Asp Gly Ile Val Ala  Thr Asp Val            
    2410                 2415                 2420                        

cca gaa  tta gag cgc acc aca  ccc atc atg cag aag  aaa gtt gga        7410
Pro Glu  Leu Glu Arg Thr Thr  Pro Ile Met Gln Lys  Lys Val Gly            
    2425                 2430                 2435                        

cag atc  atg ctg atc ttg gtg  tct cta gct gca gta  gta gtg aac        7455
Gln Ile  Met Leu Ile Leu Val  Ser Leu Ala Ala Val  Val Val Asn            
    2440                 2445                 2450                        

ccg tct  gtg aag aca gta cga  gaa gcc gga att ttg  atc acg gcc        7500
Pro Ser  Val Lys Thr Val Arg  Glu Ala Gly Ile Leu  Ile Thr Ala            
    2455                 2460                 2465                        

gca gcg  gtg acg ctt tgg gag  aat gga gca agc tct  gtt tgg aac        7545
Ala Ala  Val Thr Leu Trp Glu  Asn Gly Ala Ser Ser  Val Trp Asn            
    2470                 2475                 2480                        

gca aca  act gcc atc gga ctc  tgc cac atc atg cgt  ggg ggt tgg        7590
Ala Thr  Thr Ala Ile Gly Leu  Cys His Ile Met Arg  Gly Gly Trp            
    2485                 2490                 2495                        

ttg tca  tgt cta tcc ata aca  tgg aca ctc ata aag  aac atg gaa        7635
Leu Ser  Cys Leu Ser Ile Thr  Trp Thr Leu Ile Lys  Asn Met Glu            
    2500                 2505                 2510                        

aaa cca  gga cta aaa aga ggt  ggg gca aaa gga cgc  acc ttg gga        7680
Lys Pro  Gly Leu Lys Arg Gly  Gly Ala Lys Gly Arg  Thr Leu Gly            
    2515                 2520                 2525                        

gag gtt  tgg aaa gaa aga ctc  aac cag atg aca aaa  gaa gag ttc        7725
Glu Val  Trp Lys Glu Arg Leu  Asn Gln Met Thr Lys  Glu Glu Phe            
    2530                 2535                 2540                        

act agg  tac cgc aaa gag gcc  atc atc gaa gtc gat  cgc tca gcg        7770
Thr Arg  Tyr Arg Lys Glu Ala  Ile Ile Glu Val Asp  Arg Ser Ala            
    2545                 2550                 2555                        

gca aaa  cac gcc agg aaa gaa  ggc aat gtc act gga  ggg cat cca        7815
Ala Lys  His Ala Arg Lys Glu  Gly Asn Val Thr Gly  Gly His Pro            
    2560                 2565                 2570                        

gtc tct  agg ggc aca gca aaa  ctg aga tgg ctg gtc  gaa cgg agg        7860
Val Ser  Arg Gly Thr Ala Lys  Leu Arg Trp Leu Val  Glu Arg Arg            
    2575                 2580                 2585                        

ttt ctc  gaa ccg gtc gga aaa  gtg att gac ctt gga  tgt gga aga        7905
Phe Leu  Glu Pro Val Gly Lys  Val Ile Asp Leu Gly  Cys Gly Arg            
    2590                 2595                 2600                        

ggc ggt  tgg tgt tac tat atg  gca acc caa aaa aga  gtc caa gaa        7950
Gly Gly  Trp Cys Tyr Tyr Met  Ala Thr Gln Lys Arg  Val Gln Glu            
    2605                 2610                 2615                        

gtc aga  ggg tac aca aag ggc  ggt ccc gga cat gaa  gag ccc caa        7995
Val Arg  Gly Tyr Thr Lys Gly  Gly Pro Gly His Glu  Glu Pro Gln            
    2620                 2625                 2630                        

cta gtg  caa agt tat gga tgg  aac att gtc acc atg  aag agt gga        8040
Leu Val  Gln Ser Tyr Gly Trp  Asn Ile Val Thr Met  Lys Ser Gly            
    2635                 2640                 2645                        

gtg gat  gtg ttc tac aga cct  tct gag tgt tgt gac  acc ctc ctt        8085
Val Asp  Val Phe Tyr Arg Pro  Ser Glu Cys Cys Asp  Thr Leu Leu            
    2650                 2655                 2660                        

tgt gac  atc gga gag tcc tcg  tca agt gct gag gtt  gaa gag cat        8130
Cys Asp  Ile Gly Glu Ser Ser  Ser Ser Ala Glu Val  Glu Glu His            
    2665                 2670                 2675                        

agg acg  att cgg gtc ctt gaa  atg gtt gag gac tgg  ctg cac cga        8175
Arg Thr  Ile Arg Val Leu Glu  Met Val Glu Asp Trp  Leu His Arg            
    2680                 2685                 2690                        

ggg cca  agg gaa ttt tgc gtg  aag gtg ctc tgc ccc  tac atg ccg        8220
Gly Pro  Arg Glu Phe Cys Val  Lys Val Leu Cys Pro  Tyr Met Pro            
    2695                 2700                 2705                        

aaa gtc  ata gag aag atg gag  ctg ctc caa cgc cgg  tat ggg ggg        8265
Lys Val  Ile Glu Lys Met Glu  Leu Leu Gln Arg Arg  Tyr Gly Gly            
    2710                 2715                 2720                        

gga ctg  gtc aga aac cca ctc  tca cgg aat tcc acg  cac gag atg        8310
Gly Leu  Val Arg Asn Pro Leu  Ser Arg Asn Ser Thr  His Glu Met            
    2725                 2730                 2735                        

tat tgg  gtg agt cga gct tca  ggc aat gtg gta cat  tca gtg aat        8355
Tyr Trp  Val Ser Arg Ala Ser  Gly Asn Val Val His  Ser Val Asn            
    2740                 2745                 2750                        

atg acc  agc cag gtg ctc cta  gga aga atg gaa aaa  agg acc tgg        8400
Met Thr  Ser Gln Val Leu Leu  Gly Arg Met Glu Lys  Arg Thr Trp            
    2755                 2760                 2765                        

aag gga  ccc caa tac gag gaa  gat gta aac ttg gga  agt gga acc        8445
Lys Gly  Pro Gln Tyr Glu Glu  Asp Val Asn Leu Gly  Ser Gly Thr            
    2770                 2775                 2780                        

agg gcg  gtg gga aaa ccc ctg  ctc aac tca gac acc  agt aaa atc        8490
Arg Ala  Val Gly Lys Pro Leu  Leu Asn Ser Asp Thr  Ser Lys Ile            
    2785                 2790                 2795                        

aag aac  agg att gaa cga ctc  agg cgt gag tac agt  tcg acg tgg        8535
Lys Asn  Arg Ile Glu Arg Leu  Arg Arg Glu Tyr Ser  Ser Thr Trp            
    2800                 2805                 2810                        

cac cac  gat gag aac cac cca  tat aga acc tgg aac  tat cac ggc        8580
His His  Asp Glu Asn His Pro  Tyr Arg Thr Trp Asn  Tyr His Gly            
    2815                 2820                 2825                        

agt tat  gat gtg aag ccc aca  ggc tcc gcc agt tcg  ctg gtc aat        8625
Ser Tyr  Asp Val Lys Pro Thr  Gly Ser Ala Ser Ser  Leu Val Asn            
    2830                 2835                 2840                        

gga gtg  gtc agg ctc ctc tca  aaa cca tgg gac acc  atc acg aat        8670
Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp Asp Thr  Ile Thr Asn            
    2845                 2850                 2855                        

gtt acc  acc atg gcc atg act  gac act act ccc ttc  ggg cag cag        8715
Val Thr  Thr Met Ala Met Thr  Asp Thr Thr Pro Phe  Gly Gln Gln            
    2860                 2865                 2870                        

cga gtg  ttc aaa gag aag gtg  gac acg aaa gct cct  gaa ccg cca        8760
Arg Val  Phe Lys Glu Lys Val  Asp Thr Lys Ala Pro  Glu Pro Pro            
    2875                 2880                 2885                        

gaa gga  gtg aag tac gtg ctc  aac gag acc acc aac  tgg ttg tgg        8805
Glu Gly  Val Lys Tyr Val Leu  Asn Glu Thr Thr Asn  Trp Leu Trp            
    2890                 2895                 2900                        

gcg ttt  ttg gcc aga gaa aaa  cgt ccc aga atg tgc  tct cga gag        8850
Ala Phe  Leu Ala Arg Glu Lys  Arg Pro Arg Met Cys  Ser Arg Glu            
    2905                 2910                 2915                        

gaa ttc  ata aga aag gtc aac  agc aat gca gct ttg  ggt gcc atg        8895
Glu Phe  Ile Arg Lys Val Asn  Ser Asn Ala Ala Leu  Gly Ala Met            
    2920                 2925                 2930                        

ttt gaa  gag cag aat caa tgg  agg agc gcc aga gaa  gca gtt gaa        8940
Phe Glu  Glu Gln Asn Gln Trp  Arg Ser Ala Arg Glu  Ala Val Glu            
    2935                 2940                 2945                        

gat cca  aaa ttt tgg gag atg  gtg gat gag gag cgc  gag gca cat        8985
Asp Pro  Lys Phe Trp Glu Met  Val Asp Glu Glu Arg  Glu Ala His            
    2950                 2955                 2960                        

ctg cgg  ggg gaa tgt cac act  tgc att tac aac atg  atg gga aag        9030
Leu Arg  Gly Glu Cys His Thr  Cys Ile Tyr Asn Met  Met Gly Lys            
    2965                 2970                 2975                        

aga gag  aaa aaa ccc gga gag  ttc gga aag gcc aag  gga agc aga        9075
Arg Glu  Lys Lys Pro Gly Glu  Phe Gly Lys Ala Lys  Gly Ser Arg            
    2980                 2985                 2990                        

gcc att  tgg ttc atg tgg ctc  gga gct cgc ttt ctg  gag ttc gag        9120
Ala Ile  Trp Phe Met Trp Leu  Gly Ala Arg Phe Leu  Glu Phe Glu            
    2995                 3000                 3005                        

gct ctg  ggt ttt ctc aat gaa  gac cac tgg ctt gga  aga aag aac        9165
Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp Leu Gly  Arg Lys Asn            
    3010                 3015                 3020                        

tca gga  gga ggt gtc gag ggc  ttg ggc ctc caa aaa  ctg ggt tac        9210
Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu Gln Lys  Leu Gly Tyr            
    3025                 3030                 3035                        

atc ctg  cgt gaa gtt ggc acc  cgg cct ggg ggc aag  atc tat gct        9255
Ile Leu  Arg Glu Val Gly Thr  Arg Pro Gly Gly Lys  Ile Tyr Ala            
    3040                 3045                 3050                        

gat gac  aca gct ggc tgg gac  acc cgc atc acg aga  gct gac ttg        9300
Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile Thr Arg  Ala Asp Leu            
    3055                 3060                 3065                        

gaa aat  gaa gct aag gtg ctt  gag ctg ctt gat ggg  gaa cat cgg        9345
Glu Asn  Glu Ala Lys Val Leu  Glu Leu Leu Asp Gly  Glu His Arg            
    3070                 3075                 3080                        

cgt ctt  gcc agg gcc atc att  gag ctc acc tat cgt  cac aaa gtt        9390
Arg Leu  Ala Arg Ala Ile Ile  Glu Leu Thr Tyr Arg  His Lys Val            
    3085                 3090                 3095                        

gtg aaa  gtg atg cgc ccg gct  gct gat gga aga acc  gtc atg gat        9435
Val Lys  Val Met Arg Pro Ala  Ala Asp Gly Arg Thr  Val Met Asp            
    3100                 3105                 3110                        

gtt atc  tcc aga gaa gat cag  agg ggg agt gga caa  gtt gtc acc        9480
Val Ile  Ser Arg Glu Asp Gln  Arg Gly Ser Gly Gln  Val Val Thr            
    3115                 3120                 3125                        

tac gcc  cta aac act ttc acc  aac ctg gcc gtc cag  ctg gtg agg        9525
Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Ala Val Gln  Leu Val Arg            
    3130                 3135                 3140                        

atg atg  gaa ggg gaa gga gtg  att ggc cca gat gat  gtg gag aaa        9570
Met Met  Glu Gly Glu Gly Val  Ile Gly Pro Asp Asp  Val Glu Lys            
    3145                 3150                 3155                        

ctc aca  aaa ggg aaa gga ccc  aaa gtc agg acc tgg  ctg ttt gag        9615
Leu Thr  Lys Gly Lys Gly Pro  Lys Val Arg Thr Trp  Leu Phe Glu            
    3160                 3165                 3170                        

aat ggg  gaa gaa aga ctc agc  cgc atg gct gtc agt  gga gat gac        9660
Asn Gly  Glu Glu Arg Leu Ser  Arg Met Ala Val Ser  Gly Asp Asp            
    3175                 3180                 3185                        

tgt gtg  gta aag ccc ctg gac  gat cgc ttt gcc acc  tcg ctc cac        9705
Cys Val  Val Lys Pro Leu Asp  Asp Arg Phe Ala Thr  Ser Leu His            
    3190                 3195                 3200                        

ttc ctc  aat gct atg tca aag  gtt cgc aaa gac atc  caa gag tgg        9750
Phe Leu  Asn Ala Met Ser Lys  Val Arg Lys Asp Ile  Gln Glu Trp            
    3205                 3210                 3215                        

aaa ccg  tca act gga tgg tat  gat tgg cag cag gtt  cca ttt tgc        9795
Lys Pro  Ser Thr Gly Trp Tyr  Asp Trp Gln Gln Val  Pro Phe Cys            
    3220                 3225                 3230                        

tca aac  cat ttc act gaa ttg  atc atg aaa gat gga  aga aca ctg        9840
Ser Asn  His Phe Thr Glu Leu  Ile Met Lys Asp Gly  Arg Thr Leu            
    3235                 3240                 3245                        

gtg gtt  cca tgc cga gga cag  gat gaa ttg gta ggc  aga gct cgc        9885
Val Val  Pro Cys Arg Gly Gln  Asp Glu Leu Val Gly  Arg Ala Arg            
    3250                 3255                 3260                        

ata tct  cca ggg gcc gga tgg  aac gtc cgc gac act  gct tgt ctg        9930
Ile Ser  Pro Gly Ala Gly Trp  Asn Val Arg Asp Thr  Ala Cys Leu            
    3265                 3270                 3275                        

gct aag  tct tat gcc cag atg  tgg ctg ctt ctg tac  ttc cac aga        9975
Ala Lys  Ser Tyr Ala Gln Met  Trp Leu Leu Leu Tyr  Phe His Arg            
    3280                 3285                 3290                        

aga gac  ctg cgg ctc atg gcc  aac gcc att tgc tcc  gct gtc cct       10020
Arg Asp  Leu Arg Leu Met Ala  Asn Ala Ile Cys Ser  Ala Val Pro            
    3295                 3300                 3305                        

gtg aat  tgg gtc cct acc gga  aga acc acg tgg tcc  atc cat gca       10065
Val Asn  Trp Val Pro Thr Gly  Arg Thr Thr Trp Ser  Ile His Ala            
    3310                 3315                 3320                        

gga gga  gag tgg atg aca aca  gag gac atg ttg gag  gtc tgg aac       10110
Gly Gly  Glu Trp Met Thr Thr  Glu Asp Met Leu Glu  Val Trp Asn            
    3325                 3330                 3335                        

cgt gtt  tgg ata gag gag aat  gaa tgg atg gaa gac  aaa acc cca       10155
Arg Val  Trp Ile Glu Glu Asn  Glu Trp Met Glu Asp  Lys Thr Pro            
    3340                 3345                 3350                        

gtg gag  aaa tgg agt gac gtc  cca tat tca gga aaa  cga gag gac       10200
Val Glu  Lys Trp Ser Asp Val  Pro Tyr Ser Gly Lys  Arg Glu Asp            
    3355                 3360                 3365                        

atc tgg  tgt ggc agc ctg att  ggc aca aga gcc cga  gcc acg tgg       10245
Ile Trp  Cys Gly Ser Leu Ile  Gly Thr Arg Ala Arg  Ala Thr Trp            
    3370                 3375                 3380                        

gca gaa  aac atc cag gtg gct  atc aac caa gtc aga  gca atc atc       10290
Ala Glu  Asn Ile Gln Val Ala  Ile Asn Gln Val Arg  Ala Ile Ile            
    3385                 3390                 3395                        

gga gat  gag aag tat gtg gat  tac atg agt tca cta  aag aga tat       10335
Gly Asp  Glu Lys Tyr Val Asp  Tyr Met Ser Ser Leu  Lys Arg Tyr            
    3400                 3405                 3410                        

gaa gac  aca act ttg gtt gag  gac aca gta ctg tag atatttaatc         10381
Glu Asp  Thr Thr Leu Val Glu  Asp Thr Val Leu                             
    3415                 3420                                             

aattgtaaat agacaatata agtatgcata aaagtgtagt tttatagtag tatttagtgg    10441

tgttagtgta aatagttaag aaaattttga ggagaaagtc aggccgggaa gttcccgcca    10501

ccggaagttg agtagacggt gctgcctgcg actcaacccc aggaggactg ggtgaacaaa    10561

gccgcgaagt gatccatgta agccctcaga accgtctcgg aaggaggacc ccacatgttg    10621

taacttcaaa gcccaatgtc agaccacgct acggcgtgct actctgcgga gagtgcagtc    10681

tgcgatagtg ccccaggagg actgggttaa caaaggcaaa ccaacgcccc acgcggccct    10741

agccccggta atggtgttaa ccagggcgaa aggactagag gttagaggag accccgcggt    10801

ttaaagtgca cggcccagcc tggctgaagc tgtaggtcag gggaaggact agaggttagt    10861

ggagaccccg tgccacaaaa caccacaaca aaacagcata ttgacacctg ggatagacta    10921

ggagatcttc tgctctgcac aaccagccac acggcacagt gcgccgacaa tggtggctgg    10981

tggtgcgaga acacaggatc t                                              11002


<210>  16
<211>  3424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Gly Gly Lys Thr Gly Ile Leu 
            100                 105                 110         


Cys Leu Met Met Met Leu Pro Ala Thr Leu Ala Phe His Leu Thr Ser 
        115                 120                 125             


Arg Asp Gly Glu Pro Arg Met Ile Val Gly Lys Asn Glu Arg Gly Lys 
    130                 135                 140                 


Ser Leu Leu Phe Lys Thr Ala Ser Gly Ile Asn Met Cys Thr Leu Ile 
145                 150                 155                 160 


Ala Met Asp Leu Gly Glu Met Cys Asp Asp Thr Val Thr Tyr Lys Cys 
                165                 170                 175     


Pro His Ile Thr Glu Val Glu Pro Glu Asp Ile Asp Cys Trp Cys Asn 
            180                 185                 190         


Leu Thr Ser Thr Trp Val Thr Tyr Gly Thr Cys Asn Gln Ala Gly Glu 
        195                 200                 205             


His Arg Arg Asp Lys Arg Ser Val Ala Leu Ala Pro His Val Gly Met 
    210                 215                 220                 


Gly Leu Asp Thr Arg Thr Gln Thr Trp Met Ser Ala Glu Gly Ala Trp 
225                 230                 235                 240 


Arg Gln Val Glu Lys Val Glu Thr Trp Ala Leu Arg His Pro Gly Phe 
                245                 250                 255     


Thr Ile Leu Ala Leu Phe Leu Ala His Tyr Ile Gly Thr Ser Leu Thr 
            260                 265                 270         


Gln Lys Val Val Ile Phe Ile Leu Leu Met Leu Val Thr Pro Ser Met 
        275                 280                 285             


Thr Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Leu 
    290                 295                 300                 


Ser Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val 
305                 310                 315                 320 


Thr Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Gln Lys 
                325                 330                 335     


Thr Glu Ala Thr Gln Leu Ala Thr Leu Arg Lys Leu Cys Ile Glu Gly 
            340                 345                 350         


Lys Ile Thr Asn Ile Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu 
        355                 360                 365             


Ala Ile Leu Pro Glu Glu Gln Asp Gln Asn Tyr Val Cys Lys His Thr 
    370                 375                 380                 


Tyr Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly 
385                 390                 395                 400 


Ser Leu Val Thr Cys Ala Lys Phe Gln Cys Leu Glu Ser Ile Glu Gly 
                405                 410                 415     


Lys Val Val Gln His Glu Asn Leu Lys Tyr Thr Val Ile Ile Thr Val 
            420                 425                 430         


His Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Gln Gly Val Thr 
        435                 440                 445             


Ala Glu Ile Thr Pro Gln Ala Ser Thr Ala Glu Ala Ile Leu Pro Glu 
    450                 455                 460                 


Tyr Gly Thr Leu Gly Leu Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe 
465                 470                 475                 480 


Asn Glu Met Ile Ser Leu Thr Met Lys Asn Lys Ala Trp Met Val His 
                485                 490                 495     


Arg Gln Trp Phe Phe Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala Thr 
            500                 505                 510         


Ala Glu Thr Pro Thr Trp Asn Arg Lys Glu Leu Leu Val Thr Phe Lys 
        515                 520                 525             


Asn Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln Glu 
    530                 535                 540                 


Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr Ser 
545                 550                 555                 560 


Gly Gly Thr Ser Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys Met 
                565                 570                 575     


Asp Lys Leu Glu Leu Lys Gly Met Ser Tyr Ala Met Cys Leu Ser Ser 
            580                 585                 590         


Phe Val Leu Lys Lys Glu Val Ser Glu Thr Gln His Gly Thr Ile Leu 
        595                 600                 605             


Ile Lys Val Glu Tyr Lys Gly Glu Asp Ala Pro Cys Lys Ile Pro Phe 
    610                 615                 620                 


Ser Thr Glu Asp Gly Gln Gly Lys Ala Leu Asn Gly Arg Leu Ile Thr 
625                 630                 635                 640 


Ala Asn Pro Val Val Thr Lys Lys Glu Glu Pro Val Asn Ile Glu Ala 
                645                 650                 655     


Glu Pro Pro Phe Gly Glu Ser Asn Ile Val Ile Gly Ile Gly Asp Lys 
            660                 665                 670         


Ala Leu Lys Ile Asn Trp Tyr Lys Lys Gly Ser Ser Ile Gly Lys Met 
        675                 680                 685             


Phe Glu Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly Asp 
    690                 695                 700                 


Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Leu Asn Ser Leu Gly 
705                 710                 715                 720 


Lys Met Val His Gln Ile Phe Gly Ser Ala Tyr Thr Ala Leu Phe Gly 
                725                 730                 735     


Gly Val Ser Trp Met Met Lys Ile Gly Ile Gly Val Leu Leu Thr Trp 
            740                 745                 750         


Ile Gly Leu Asn Ser Lys Asn Thr Ser Met Ser Phe Ser Cys Ile Ala 
        755                 760                 765             


Ile Gly Ile Ile Thr Leu Tyr Leu Gly Ala Val Val Gln Ala Asp Ser 
    770                 775                 780                 


Gly Cys Ala Ile Asp Ile Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly 
785                 790                 795                 800 


Val Phe Ile His Asn Asp Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr 
                805                 810                 815     


Tyr Pro Glu Thr Pro Gln Gly Leu Ala Lys Ile Ile Gln Lys Ala His 
            820                 825                 830         


Lys Glu Gly Val Cys Gly Leu Arg Ser Val Ser Arg Leu Glu His Gln 
        835                 840                 845             


Met Trp Glu Ala Val Lys Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn 
    850                 855                 860                 


Gly Val Asp Leu Ser Val Val Val Glu Lys Gln Glu Gly Met Tyr Lys 
865                 870                 875                 880 


Ser Ala Pro Lys Arg Leu Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly 
                885                 890                 895     


Trp Lys Ala Trp Gly Lys Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn 
            900                 905                 910         


Asn Thr Phe Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln 
        915                 920                 925             


Asn Arg Ala Trp Asn Ser Leu Glu Val Glu Asp Phe Gly Phe Gly Leu 
    930                 935                 940                 


Thr Ser Thr Arg Met Phe Leu Lys Val Arg Glu Ser Asn Thr Thr Glu 
945                 950                 955                 960 


Cys Asp Ser Lys Ile Ile Gly Thr Ala Val Lys Asn Asn Leu Ala Ile 
                965                 970                 975     


His Ser Asp Leu Ser Tyr Trp Ile Glu Ser Arg Leu Asn Asp Thr Trp 
            980                 985                 990         


Lys Leu Glu Arg Ala Val Leu Gly  Glu Val Lys Ser Cys  Thr Trp Pro 
        995                 1000                 1005             


Glu Thr  His Thr Leu Trp Gly  Asp Gly Ile Leu Glu  Ser Asp Leu 
    1010                 1015                 1020             


Ile Ile  Pro Val Thr Leu Ala  Gly Pro Arg Ser Asn  His Asn Arg 
    1025                 1030                 1035             


Arg Pro  Gly Tyr Lys Thr Gln  Asn Gln Gly Pro Trp  Asp Glu Gly 
    1040                 1045                 1050             


Arg Val  Glu Ile Asp Phe Asp  Tyr Cys Pro Gly Thr  Thr Val Thr 
    1055                 1060                 1065             


Leu Ser  Glu Ser Cys Gly His  Arg Gly Pro Ala Thr  Arg Thr Thr 
    1070                 1075                 1080             


Thr Glu  Ser Gly Lys Leu Ile  Thr Asp Trp Cys Cys  Arg Ser Cys 
    1085                 1090                 1095             


Thr Leu  Pro Pro Leu Arg Tyr  Gln Thr Asp Ser Gly  Cys Trp Tyr 
    1100                 1105                 1110             


Gly Met  Glu Ile Arg Pro Gln  Arg His Asp Glu Lys  Thr Leu Val 
    1115                 1120                 1125             


Gln Ser  Gln Val Asn Ala Tyr  Asn Ala Asp Met Ile  Asp Pro Phe 
    1130                 1135                 1140             


Gln Leu  Gly Leu Leu Val Val  Phe Leu Ala Thr Gln  Glu Val Leu 
    1145                 1150                 1155             


Arg Lys  Arg Trp Thr Ala Lys  Ile Ser Met Pro Ala  Ile Leu Ile 
    1160                 1165                 1170             


Ala Leu  Leu Val Leu Val Phe  Gly Gly Ile Thr Tyr  Thr Asp Val 
    1175                 1180                 1185             


Leu Arg  Tyr Val Ile Leu Val  Gly Ala Ala Phe Ala  Glu Ser Asn 
    1190                 1195                 1200             


Ser Gly  Gly Asp Val Val His  Leu Ala Leu Met Ala  Thr Phe Lys 
    1205                 1210                 1215             


Ile Gln  Pro Val Phe Met Val  Ala Ser Phe Leu Lys  Ala Arg Trp 
    1220                 1225                 1230             


Thr Asn  Gln Glu Asn Ile Leu  Leu Met Leu Ala Ala  Val Phe Phe 
    1235                 1240                 1245             


Gln Met  Ala Tyr Tyr Asp Ala  Arg Gln Ile Leu Leu  Trp Glu Ile 
    1250                 1255                 1260             


Pro Asp  Val Leu Asn Ser Leu  Ala Val Ala Trp Met  Ile Leu Arg 
    1265                 1270                 1275             


Ala Ile  Thr Phe Thr Thr Thr  Ser Asn Val Val Val  Pro Leu Leu 
    1280                 1285                 1290             


Ala Leu  Leu Thr Pro Gly Leu  Arg Cys Leu Asn Leu  Asp Val Tyr 
    1295                 1300                 1305             


Arg Ile  Leu Leu Leu Met Val  Gly Ile Gly Ser Leu  Ile Arg Glu 
    1310                 1315                 1320             


Lys Arg  Ser Ala Ala Ala Lys  Lys Lys Gly Ala Ser  Leu Leu Cys 
    1325                 1330                 1335             


Leu Ala  Leu Ala Ser Thr Gly  Leu Phe Asn Pro Met  Ile Leu Ala 
    1340                 1345                 1350             


Ala Gly  Leu Ile Ala Cys Asp  Pro Asn Arg Lys Arg  Gly Trp Pro 
    1355                 1360                 1365             


Ala Thr  Glu Val Met Thr Ala  Val Gly Leu Met Phe  Ala Ile Val 
    1370                 1375                 1380             


Gly Gly  Leu Ala Glu Leu Asp  Ile Asp Ser Met Ala  Ile Pro Met 
    1385                 1390                 1395             


Thr Ile  Ala Gly Leu Met Phe  Ala Ala Phe Val Ile  Ser Gly Lys 
    1400                 1405                 1410             


Ser Thr  Asp Met Trp Ile Glu  Arg Thr Ala Asp Ile  Ser Trp Glu 
    1415                 1420                 1425             


Ser Asp  Ala Glu Ile Thr Gly  Ser Ser Glu Arg Val  Asp Val Arg 
    1430                 1435                 1440             


Leu Asp  Asp Asp Gly Asn Phe  Gln Leu Met Asn Asp  Pro Gly Ala 
    1445                 1450                 1455             


Pro Trp  Lys Ile Trp Met Leu  Arg Met Val Cys Leu  Ala Ile Ser 
    1460                 1465                 1470             


Ala Tyr  Thr Pro Trp Ala Ile  Leu Pro Ser Val Val  Gly Phe Trp 
    1475                 1480                 1485             


Ile Thr  Leu Gln Tyr Thr Lys  Arg Gly Gly Val Leu  Trp Asp Thr 
    1490                 1495                 1500             


Pro Ser  Pro Lys Glu Tyr Lys  Lys Gly Asp Thr Thr  Thr Gly Val 
    1505                 1510                 1515             


Tyr Arg  Ile Met Thr Arg Gly  Leu Leu Gly Ser Tyr  Gln Ala Gly 
    1520                 1525                 1530             


Ala Gly  Val Met Val Glu Gly  Val Phe His Thr Leu  Trp His Thr 
    1535                 1540                 1545             


Thr Lys  Gly Ala Ala Leu Met  Ser Gly Glu Gly Arg  Leu Asp Pro 
    1550                 1555                 1560             


Tyr Trp  Gly Ser Val Lys Glu  Asp Arg Leu Cys Tyr  Gly Gly Pro 
    1565                 1570                 1575             


Trp Lys  Leu Gln His Lys Trp  Asn Gly Gln Asp Glu  Val Gln Met 
    1580                 1585                 1590             


Ile Val  Val Glu Pro Gly Arg  Asn Val Lys Asn Val  Gln Thr Lys 
    1595                 1600                 1605             


Pro Gly  Val Phe Lys Thr Pro  Glu Gly Glu Ile Gly  Ala Val Thr 
    1610                 1615                 1620             


Leu Asp  Phe Pro Thr Gly Thr  Ser Gly Ser Pro Ile  Val Asp Lys 
    1625                 1630                 1635             


Asn Gly  Asp Val Ile Gly Leu  Tyr Gly Asn Gly Val  Ile Met Pro 
    1640                 1645                 1650             


Asn Gly  Ser Tyr Ile Ser Ala  Ile Val Gln Gly Glu  Arg Met Asp 
    1655                 1660                 1665             


Glu Pro  Ile Pro Ala Gly Phe  Glu Pro Glu Met Leu  Arg Lys Lys 
    1670                 1675                 1680             


Gln Ile  Thr Val Leu Asp Leu  His Pro Gly Ala Gly  Lys Thr Arg 
    1685                 1690                 1695             


Arg Ile  Leu Pro Gln Ile Ile  Lys Glu Ala Ile Asn  Arg Arg Leu 
    1700                 1705                 1710             


Arg Thr  Ala Val Leu Ala Pro  Thr Arg Val Val Ala  Ala Glu Met 
    1715                 1720                 1725             


Ala Glu  Ala Leu Arg Gly Leu  Pro Ile Arg Tyr Gln  Thr Ser Ala 
    1730                 1735                 1740             


Val Pro  Arg Glu His Asn Gly  Asn Glu Ile Val Asp  Val Met Cys 
    1745                 1750                 1755             


His Ala  Thr Leu Thr His Arg  Leu Met Ser Pro His  Arg Val Pro 
    1760                 1765                 1770             


Asn Tyr  Asn Leu Phe Val Met  Asp Glu Ala His Phe  Thr Asp Pro 
    1775                 1780                 1785             


Ala Ser  Ile Ala Ala Arg Gly  Tyr Ile Ser Thr Lys  Val Glu Leu 
    1790                 1795                 1800             


Gly Glu  Ala Ala Ala Ile Phe  Met Thr Ala Thr Pro  Pro Gly Thr 
    1805                 1810                 1815             


Ser Asp  Pro Phe Pro Glu Ser  Asn Ser Pro Ile Ser  Asp Leu Gln 
    1820                 1825                 1830             


Thr Glu  Ile Pro Asp Arg Ala  Trp Asn Ser Gly Tyr  Glu Trp Ile 
    1835                 1840                 1845             


Thr Glu  Tyr Thr Gly Lys Thr  Val Trp Phe Val Pro  Ser Val Lys 
    1850                 1855                 1860             


Met Gly  Asn Glu Ile Ala Leu  Cys Leu Gln Arg Ala  Gly Lys Lys 
    1865                 1870                 1875             


Val Val  Gln Leu Asn Arg Lys  Ser Tyr Glu Thr Glu  Tyr Pro Lys 
    1880                 1885                 1890             


Cys Lys  Asn Asp Asp Trp Asp  Phe Val Ile Thr Thr  Asp Ile Ser 
    1895                 1900                 1905             


Glu Met  Gly Ala Asn Phe Lys  Ala Ser Arg Val Ile  Asp Ser Arg 
    1910                 1915                 1920             


Lys Ser  Val Lys Pro Thr Ile  Ile Thr Glu Gly Glu  Gly Arg Val 
    1925                 1930                 1935             


Ile Leu  Gly Glu Pro Ser Ala  Val Thr Ala Ala Ser  Ala Ala Gln 
    1940                 1945                 1950             


Arg Arg  Gly Arg Ile Gly Arg  Asn Pro Ser Gln Val  Gly Asp Glu 
    1955                 1960                 1965             


Tyr Cys  Tyr Gly Gly His Thr  Asn Glu Asp Asp Ser  Asn Phe Ala 
    1970                 1975                 1980             


His Trp  Thr Glu Ala Arg Ile  Met Leu Asp Asn Ile  Asn Met Pro 
    1985                 1990                 1995             


Asn Gly  Leu Ile Ala Gln Phe  Tyr Gln Pro Glu Arg  Glu Lys Val 
    2000                 2005                 2010             


Tyr Thr  Met Asp Gly Glu Tyr  Arg Leu Arg Gly Glu  Glu Arg Lys 
    2015                 2020                 2025             


Asn Phe  Leu Glu Leu Leu Arg  Thr Ala Asp Leu Pro  Val Trp Leu 
    2030                 2035                 2040             


Ala Tyr  Lys Val Ala Ala Ala  Gly Val Ser Tyr His  Asp Arg Arg 
    2045                 2050                 2055             


Trp Cys  Phe Asp Gly Pro Arg  Thr Asn Thr Ile Leu  Glu Asp Asn 
    2060                 2065                 2070             


Asn Glu  Val Glu Val Ile Thr  Lys Leu Gly Glu Arg  Lys Ile Leu 
    2075                 2080                 2085             


Arg Pro  Arg Trp Ile Asp Ala  Arg Val Tyr Ser Asp  His Gln Ala 
    2090                 2095                 2100             


Leu Lys  Ala Phe Lys Asp Phe  Ala Ser Gly Lys Arg  Ser Gln Ile 
    2105                 2110                 2115             


Gly Leu  Ile Glu Val Leu Gly  Lys Met Pro Glu His  Phe Met Gly 
    2120                 2125                 2130             


Lys Thr  Trp Glu Ala Leu Asp  Thr Met Tyr Val Val  Ala Thr Ala 
    2135                 2140                 2145             


Glu Lys  Gly Gly Arg Ala His  Arg Met Ala Leu Glu  Glu Leu Pro 
    2150                 2155                 2160             


Asp Ala  Leu Gln Thr Ile Ala  Leu Ile Ala Leu Leu  Ser Val Met 
    2165                 2170                 2175             


Thr Met  Gly Val Phe Phe Leu  Leu Met Gln Arg Lys  Gly Ile Gly 
    2180                 2185                 2190             


Lys Ile  Gly Leu Gly Gly Ala  Val Leu Gly Val Ala  Thr Phe Phe 
    2195                 2200                 2205             


Cys Trp  Met Ala Glu Val Pro  Gly Thr Lys Ile Ala  Gly Met Leu 
    2210                 2215                 2220             


Leu Leu  Ser Leu Leu Leu Met  Ile Val Leu Ile Pro  Glu Pro Glu 
    2225                 2230                 2235             


Lys Gln  Arg Ser Gln Thr Asp  Asn Gln Leu Ala Val  Phe Leu Ile 
    2240                 2245                 2250             


Cys Val  Met Thr Leu Val Ser  Ala Val Ala Ala Asn  Glu Met Gly 
    2255                 2260                 2265             


Trp Leu  Asp Lys Thr Lys Ser  Asp Ile Ser Ser Leu  Phe Gly Gln 
    2270                 2275                 2280             


Arg Ile  Glu Val Lys Glu Asn  Phe Ser Met Gly Glu  Phe Leu Leu 
    2285                 2290                 2295             


Asp Leu  Arg Pro Ala Thr Ala  Trp Ser Leu Tyr Ala  Val Thr Thr 
    2300                 2305                 2310             


Ala Val  Leu Thr Pro Leu Leu  Lys His Leu Ile Thr  Ser Asp Tyr 
    2315                 2320                 2325             


Ile Asn  Thr Ser Leu Thr Ser  Ile Asn Val Gln Ala  Ser Ala Leu 
    2330                 2335                 2340             


Phe Thr  Leu Ala Arg Gly Phe  Pro Phe Val Asp Val  Gly Val Ser 
    2345                 2350                 2355             


Ala Leu  Leu Leu Ala Ala Gly  Cys Trp Gly Gln Val  Thr Leu Thr 
    2360                 2365                 2370             


Val Thr  Val Thr Ala Ala Thr  Leu Leu Phe Cys His  Tyr Ala Tyr 
    2375                 2380                 2385             


Met Val  Pro Gly Trp Gln Ala  Glu Ala Met Arg Ser  Ala Gln Arg 
    2390                 2395                 2400             


Arg Thr  Ala Ala Gly Ile Met  Lys Asn Ala Val Val  Asp Gly Ile 
    2405                 2410                 2415             


Val Ala  Thr Asp Val Pro Glu  Leu Glu Arg Thr Thr  Pro Ile Met 
    2420                 2425                 2430             


Gln Lys  Lys Val Gly Gln Ile  Met Leu Ile Leu Val  Ser Leu Ala 
    2435                 2440                 2445             


Ala Val  Val Val Asn Pro Ser  Val Lys Thr Val Arg  Glu Ala Gly 
    2450                 2455                 2460             


Ile Leu  Ile Thr Ala Ala Ala  Val Thr Leu Trp Glu  Asn Gly Ala 
    2465                 2470                 2475             


Ser Ser  Val Trp Asn Ala Thr  Thr Ala Ile Gly Leu  Cys His Ile 
    2480                 2485                 2490             


Met Arg  Gly Gly Trp Leu Ser  Cys Leu Ser Ile Thr  Trp Thr Leu 
    2495                 2500                 2505             


Ile Lys  Asn Met Glu Lys Pro  Gly Leu Lys Arg Gly  Gly Ala Lys 
    2510                 2515                 2520             


Gly Arg  Thr Leu Gly Glu Val  Trp Lys Glu Arg Leu  Asn Gln Met 
    2525                 2530                 2535             


Thr Lys  Glu Glu Phe Thr Arg  Tyr Arg Lys Glu Ala  Ile Ile Glu 
    2540                 2545                 2550             


Val Asp  Arg Ser Ala Ala Lys  His Ala Arg Lys Glu  Gly Asn Val 
    2555                 2560                 2565             


Thr Gly  Gly His Pro Val Ser  Arg Gly Thr Ala Lys  Leu Arg Trp 
    2570                 2575                 2580             


Leu Val  Glu Arg Arg Phe Leu  Glu Pro Val Gly Lys  Val Ile Asp 
    2585                 2590                 2595             


Leu Gly  Cys Gly Arg Gly Gly  Trp Cys Tyr Tyr Met  Ala Thr Gln 
    2600                 2605                 2610             


Lys Arg  Val Gln Glu Val Arg  Gly Tyr Thr Lys Gly  Gly Pro Gly 
    2615                 2620                 2625             


His Glu  Glu Pro Gln Leu Val  Gln Ser Tyr Gly Trp  Asn Ile Val 
    2630                 2635                 2640             


Thr Met  Lys Ser Gly Val Asp  Val Phe Tyr Arg Pro  Ser Glu Cys 
    2645                 2650                 2655             


Cys Asp  Thr Leu Leu Cys Asp  Ile Gly Glu Ser Ser  Ser Ser Ala 
    2660                 2665                 2670             


Glu Val  Glu Glu His Arg Thr  Ile Arg Val Leu Glu  Met Val Glu 
    2675                 2680                 2685             


Asp Trp  Leu His Arg Gly Pro  Arg Glu Phe Cys Val  Lys Val Leu 
    2690                 2695                 2700             


Cys Pro  Tyr Met Pro Lys Val  Ile Glu Lys Met Glu  Leu Leu Gln 
    2705                 2710                 2715             


Arg Arg  Tyr Gly Gly Gly Leu  Val Arg Asn Pro Leu  Ser Arg Asn 
    2720                 2725                 2730             


Ser Thr  His Glu Met Tyr Trp  Val Ser Arg Ala Ser  Gly Asn Val 
    2735                 2740                 2745             


Val His  Ser Val Asn Met Thr  Ser Gln Val Leu Leu  Gly Arg Met 
    2750                 2755                 2760             


Glu Lys  Arg Thr Trp Lys Gly  Pro Gln Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Gly Lys Pro Leu  Leu Asn Ser 
    2780                 2785                 2790             


Asp Thr  Ser Lys Ile Lys Asn  Arg Ile Glu Arg Leu  Arg Arg Glu 
    2795                 2800                 2805             


Tyr Ser  Ser Thr Trp His His  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Asn  Tyr His Gly Ser Tyr  Asp Val Lys Pro Thr  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Val Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Thr  Ile Thr Asn Val Thr  Thr Met Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Phe  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Lys 
    2870                 2875                 2880             


Ala Pro  Glu Pro Pro Glu Gly  Val Lys Tyr Val Leu  Asn Glu Thr 
    2885                 2890                 2895             


Thr Asn  Trp Leu Trp Ala Phe  Leu Ala Arg Glu Lys  Arg Pro Arg 
    2900                 2905                 2910             


Met Cys  Ser Arg Glu Glu Phe  Ile Arg Lys Val Asn  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Met Phe Glu  Glu Gln Asn Gln Trp  Arg Ser Ala 
    2930                 2935                 2940             


Arg Glu  Ala Val Glu Asp Pro  Lys Phe Trp Glu Met  Val Asp Glu 
    2945                 2950                 2955             


Glu Arg  Glu Ala His Leu Arg  Gly Glu Cys His Thr  Cys Ile Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Pro Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Phe Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Leu Gly  Arg Lys Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Lys  Leu Gly Tyr Ile Leu  Arg Glu Val Gly Thr  Arg Pro Gly 
    3035                 3040                 3045             


Gly Lys  Ile Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Thr Arg  Ala Asp Leu Glu Asn  Glu Ala Lys Val Leu  Glu Leu Leu 
    3065                 3070                 3075             


Asp Gly  Glu His Arg Arg Leu  Ala Arg Ala Ile Ile  Glu Leu Thr 
    3080                 3085                 3090             


Tyr Arg  His Lys Val Val Lys  Val Met Arg Pro Ala  Ala Asp Gly 
    3095                 3100                 3105             


Arg Thr  Val Met Asp Val Ile  Ser Arg Glu Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Ala 
    3125                 3130                 3135             


Val Gln  Leu Val Arg Met Met  Glu Gly Glu Gly Val  Ile Gly Pro 
    3140                 3145                 3150             


Asp Asp  Val Glu Lys Leu Thr  Lys Gly Lys Gly Pro  Lys Val Arg 
    3155                 3160                 3165             


Thr Trp  Leu Phe Glu Asn Gly  Glu Glu Arg Leu Ser  Arg Met Ala 
    3170                 3175                 3180             


Val Ser  Gly Asp Asp Cys Val  Val Lys Pro Leu Asp  Asp Arg Phe 
    3185                 3190                 3195             


Ala Thr  Ser Leu His Phe Leu  Asn Ala Met Ser Lys  Val Arg Lys 
    3200                 3205                 3210             


Asp Ile  Gln Glu Trp Lys Pro  Ser Thr Gly Trp Tyr  Asp Trp Gln 
    3215                 3220                 3225             


Gln Val  Pro Phe Cys Ser Asn  His Phe Thr Glu Leu  Ile Met Lys 
    3230                 3235                 3240             


Asp Gly  Arg Thr Leu Val Val  Pro Cys Arg Gly Gln  Asp Glu Leu 
    3245                 3250                 3255             


Val Gly  Arg Ala Arg Ile Ser  Pro Gly Ala Gly Trp  Asn Val Arg 
    3260                 3265                 3270             


Asp Thr  Ala Cys Leu Ala Lys  Ser Tyr Ala Gln Met  Trp Leu Leu 
    3275                 3280                 3285             


Leu Tyr  Phe His Arg Arg Asp  Leu Arg Leu Met Ala  Asn Ala Ile 
    3290                 3295                 3300             


Cys Ser  Ala Val Pro Val Asn  Trp Val Pro Thr Gly  Arg Thr Thr 
    3305                 3310                 3315             


Trp Ser  Ile His Ala Gly Gly  Glu Trp Met Thr Thr  Glu Asp Met 
    3320                 3325                 3330             


Leu Glu  Val Trp Asn Arg Val  Trp Ile Glu Glu Asn  Glu Trp Met 
    3335                 3340                 3345             


Glu Asp  Lys Thr Pro Val Glu  Lys Trp Ser Asp Val  Pro Tyr Ser 
    3350                 3355                 3360             


Gly Lys  Arg Glu Asp Ile Trp  Cys Gly Ser Leu Ile  Gly Thr Arg 
    3365                 3370                 3375             


Ala Arg  Ala Thr Trp Ala Glu  Asn Ile Gln Val Ala  Ile Asn Gln 
    3380                 3385                 3390             


Val Arg  Ala Ile Ile Gly Asp  Glu Lys Tyr Val Asp  Tyr Met Ser 
    3395                 3400                 3405             


Ser Leu  Lys Arg Tyr Glu Asp  Thr Thr Leu Val Glu  Asp Thr Val 
    3410                 3415                 3420             


Leu 
    


<210>  17
<211>  11002
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   WN/DEN3 chimera with E345 His to Leu mutation (CE345)


<220>
<221>  CDS
<222>  (97)..(10371)

<400>  17
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcg atg tct aag aaa cca gga        114
                                        Met Ser Lys Lys Pro Gly           
                                        1               5                 

ggg ccc ggc aag agc cgg gct gtc aat atg cta aaa cgc gga atg ccc        162
Gly Pro Gly Lys Ser Arg Ala Val Asn Met Leu Lys Arg Gly Met Pro           
            10                  15                  20                    

cgc gtg ttg tcc ttg att gga ctg aag agg gct atg ttg agc ctg atc        210
Arg Val Leu Ser Leu Ile Gly Leu Lys Arg Ala Met Leu Ser Leu Ile           
        25                  30                  35                        

gac ggc aag ggg cca ata cga ttt gtg ttg gct ctc ttg gcg ttc ttc        258
Asp Gly Lys Gly Pro Ile Arg Phe Val Leu Ala Leu Leu Ala Phe Phe           
    40                  45                  50                            

agg ttc aca gca att gct ccg acc cga gca gtg ctg gat cga tgg aga        306
Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala Val Leu Asp Arg Trp Arg           
55                  60                  65                  70            

ggt gtg aac aaa caa aca gcg atg aaa cac ctt ctg agt ttt aag aag        354
Gly Val Asn Lys Gln Thr Ala Met Lys His Leu Leu Ser Phe Lys Lys           
                75                  80                  85                

gaa cta ggg acc ttg acc agt gct atc aat cgg cgg agt tcg aaa caa        402
Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn Arg Arg Ser Ser Lys Gln           
            90                  95                  100                   

aag aaa aga gga gga aag acc gga att gca gtc atg att ggc ctg atc        450
Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala Val Met Ile Gly Leu Ile           
        105                 110                 115                       

gcc agc gta gga gct ttc cac tta act tca cga gat gga gag ccg cgc        498
Ala Ser Val Gly Ala Phe His Leu Thr Ser Arg Asp Gly Glu Pro Arg           
    120                 125                 130                           

atg att gtg ggg aag aat gaa aga gga aaa tcc cta ctt ttc aag aca        546
Met Ile Val Gly Lys Asn Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr           
135                 140                 145                 150           

gcc tct gga atc aac atg tgc aca ctc ata gcc atg gat ctg gga gag        594
Ala Ser Gly Ile Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu           
                155                 160                 165               

atg tgt gat gac acg gtc act tac aaa tgc ccc cac att acc gaa gtg        642
Met Cys Asp Asp Thr Val Thr Tyr Lys Cys Pro His Ile Thr Glu Val           
            170                 175                 180                   

gag cct gaa gac att gac tgc tgg tgc aac ctt aca tcg aca tgg gtg        690
Glu Pro Glu Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val           
        185                 190                 195                       

act tat gga aca tgc aat caa gct gga gag cat aga cgc gat aag aga        738
Thr Tyr Gly Thr Cys Asn Gln Ala Gly Glu His Arg Arg Asp Lys Arg           
    200                 205                 210                           

tca gtg gcg tta gct ccc cat gtt ggc atg gga ctg gac aca cgc act        786
Ser Val Ala Leu Ala Pro His Val Gly Met Gly Leu Asp Thr Arg Thr           
215                 220                 225                 230           

caa acc tgg atg tcg gct gaa gga gct tgg aga caa gtc gag aag gta        834
Gln Thr Trp Met Ser Ala Glu Gly Ala Trp Arg Gln Val Glu Lys Val           
                235                 240                 245               

gag aca tgg gcc ctt agg cac cca ggg ttt acc ata cta gcc cta ttt        882
Glu Thr Trp Ala Leu Arg His Pro Gly Phe Thr Ile Leu Ala Leu Phe           
            250                 255                 260                   

ctt gcc cat tac ata ggc act tcc ttg acc cag aaa gtg gtt att ttt        930
Leu Ala His Tyr Ile Gly Thr Ser Leu Thr Gln Lys Val Val Ile Phe           
        265                 270                 275                       

ata cta tta atg ctg gtt acc cca tcc atg aca atg aga tgt gta gga        978
Ile Leu Leu Met Leu Val Thr Pro Ser Met Thr Met Arg Cys Val Gly           
    280                 285                 290                           

gta gga aac aga gat ttt gtg gaa ggc cta tcg gga gct acg tgg gtt       1026
Val Gly Asn Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val           
295                 300                 305                 310           

gac gtg gtg ctc gag cac ggt ggg tgt gtg act acc atg gct aag aac       1074
Asp Val Val Leu Glu His Gly Gly Cys Val Thr Thr Met Ala Lys Asn           
                315                 320                 325               

aag ccc acg ctg gac ata gag ctt cag aag acc gag gcc acc caa ctg       1122
Lys Pro Thr Leu Asp Ile Glu Leu Gln Lys Thr Glu Ala Thr Gln Leu           
            330                 335                 340                   

gcg acc cta agg aag cta tgc att gag gga aaa att acc aac ata aca       1170
Ala Thr Leu Arg Lys Leu Cys Ile Glu Gly Lys Ile Thr Asn Ile Thr           
        345                 350                 355                       

acc gac tca aga tgt ccc acc caa ggg gaa gcg att tta cct gag gag       1218
Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Ile Leu Pro Glu Glu           
    360                 365                 370                           

cag gac cag aac tac gtg tgt aag cat aca tac gtg gac aga ggc tgg       1266
Gln Asp Gln Asn Tyr Val Cys Lys His Thr Tyr Val Asp Arg Gly Trp           
375                 380                 385                 390           

gga aac ggt tgt ggt ttg ttt ggc aag gga agc ttg gtg aca tgc gcg       1314
Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala           
                395                 400                 405               

aaa ttt caa tgt tta gaa tca ata gag gga aaa gtg gtg caa cat gag       1362
Lys Phe Gln Cys Leu Glu Ser Ile Glu Gly Lys Val Val Gln His Glu           
            410                 415                 420                   

aac ctc aaa tac acc gtc atc atc aca gtg cac aca gga gac caa cac       1410
Asn Leu Lys Tyr Thr Val Ile Ile Thr Val His Thr Gly Asp Gln His           
        425                 430                 435                       

cag gtg gga aat gaa acg cag gga gtc acg gct gag ata aca ccc cag       1458
Gln Val Gly Asn Glu Thr Gln Gly Val Thr Ala Glu Ile Thr Pro Gln           
    440                 445                 450                           

gca tca acc gct gaa gcc att tta cct gaa tat gga acc ctc ggg cta       1506
Ala Ser Thr Ala Glu Ala Ile Leu Pro Glu Tyr Gly Thr Leu Gly Leu           
455                 460                 465                 470           

gaa tgc tca cca cgg aca ggt ttg gat ttc aat gaa atg atc tca ttg       1554
Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Ile Ser Leu           
                475                 480                 485               

aca atg aag aac aaa gca tgg atg gta cat aga caa tgg ttc ttt gac       1602
Thr Met Lys Asn Lys Ala Trp Met Val His Arg Gln Trp Phe Phe Asp           
            490                 495                 500                   

tta ccc cta cca tgg aca tca gga gct aca gca gaa aca cca act tgg       1650
Leu Pro Leu Pro Trp Thr Ser Gly Ala Thr Ala Glu Thr Pro Thr Trp           
        505                 510                 515                       

aac agg aaa gag ctt ctt gtg aca ttt aaa aat gca cat gca aaa aag       1698
Asn Arg Lys Glu Leu Leu Val Thr Phe Lys Asn Ala His Ala Lys Lys           
    520                 525                 530                           

caa gaa gta gtt gtt ctt gga tca caa gag gga gca atg cat aca gca       1746
Gln Glu Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala           
535                 540                 545                 550           

ctg aca gga gct aca gag atc caa acc tca gga ggc aca agt atc ttt       1794
Leu Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly Gly Thr Ser Ile Phe           
                555                 560                 565               

gcg ggg cac tta aaa tgt aga ctc aag atg gac aaa ttg gaa ctc aag       1842
Ala Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Glu Leu Lys           
            570                 575                 580                   

ggg atg agc tat gca atg tgc ttg agt agc ttt gtg ttg aag aaa gaa       1890
Gly Met Ser Tyr Ala Met Cys Leu Ser Ser Phe Val Leu Lys Lys Glu           
        585                 590                 595                       

gtc tcc gaa acg cag cat ggg aca ata ctc att aag gtt gag tac aaa       1938
Val Ser Glu Thr Gln His Gly Thr Ile Leu Ile Lys Val Glu Tyr Lys           
    600                 605                 610                           

ggg gaa gat gca ccc tgc aag att cct ttc tcc acg gag gat gga caa       1986
Gly Glu Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Glu Asp Gly Gln           
615                 620                 625                 630           

gga aaa gct ctc aat ggc aga ctg atc aca gcc aat cca gtg gtg acc       2034
Gly Lys Ala Leu Asn Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr           
                635                 640                 645               

aag aag gag gag cct gtc aac att gag gct gaa cct cct ttt gga gaa       2082
Lys Lys Glu Glu Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu           
            650                 655                 660                   

agt aac ata gta att gga att gga gac aaa gcc ctg aaa atc aac tgg       2130
Ser Asn Ile Val Ile Gly Ile Gly Asp Lys Ala Leu Lys Ile Asn Trp           
        665                 670                 675                       

tac aag aag gga agc tcg att ggg aag atg ttc gag gcc act gcc aga       2178
Tyr Lys Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg           
    680                 685                 690                           

ggt gca agg cgc atg gcc atc ttg gga gac aca gcc tgg gac ttt gga       2226
Gly Ala Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly           
695                 700                 705                 710           

tca gtg ggt ggt gtt ttg aat tca tta ggg aaa atg gtc cac caa ata       2274
Ser Val Gly Gly Val Leu Asn Ser Leu Gly Lys Met Val His Gln Ile           
                715                 720                 725               

ttt ggg agt gct tac aca gcc cta ttt ggt gga gtc tcc tgg atg atg       2322
Phe Gly Ser Ala Tyr Thr Ala Leu Phe Gly Gly Val Ser Trp Met Met           
            730                 735                 740                   

aaa att gga ata ggt gtc ctc tta acc tgg ata ggg ttg aac tca aaa       2370
Lys Ile Gly Ile Gly Val Leu Leu Thr Trp Ile Gly Leu Asn Ser Lys           
        745                 750                 755                       

aat act tct atg tca ttt tca tgc atc gcg ata gga atc att aca ctc       2418
Asn Thr Ser Met Ser Phe Ser Cys Ile Ala Ile Gly Ile Ile Thr Leu           
    760                 765                 770                           

tat ctg gga gcc gtg gtg caa gct gac tcc gga tgt gcc ata gac atc       2466
Tyr Leu Gly Ala Val Val Gln Ala Asp Ser Gly Cys Ala Ile Asp Ile           
775                 780                 785                 790           

agc cgg caa gag ctg aga tgt gga agt gga gtg ttc ata cac aat gat       2514
Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile His Asn Asp           
                795                 800                 805               

gtg gag gct tgg atg gac cgg tac aag tat tac cct gaa acg cca caa       2562
Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu Thr Pro Gln           
            810                 815                 820                   

ggc cta gcc aag atc att cag aaa gct cat aag gaa gga gtg tgc ggt       2610
Gly Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly Val Cys Gly           
        825                 830                 835                       

cta cga tca gtt tcc aga ctg gag cat caa atg tgg gaa gca gtg aag       2658
Leu Arg Ser Val Ser Arg Leu Glu His Gln Met Trp Glu Ala Val Lys           
    840                 845                 850                           

gac gag ctg aac act ctt ttg aag gag aat ggt gtg gac ctt agt gtc       2706
Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp Leu Ser Val           
855                 860                 865                 870           

gtg gtt gag aaa cag gag gga atg tac aag tca gca cct aaa cgc ctc       2754
Val Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro Lys Arg Leu           
                875                 880                 885               

acc gcc acc acg gaa aaa ttg gaa att ggc tgg aag gcc tgg gga aag       2802
Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala Trp Gly Lys           
            890                 895                 900                   

agt att tta ttt gca cca gaa ctc gcc aac aac acc ttt gtg gtt gat       2850
Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe Val Val Asp           
        905                 910                 915                       

ggt ccg gag acc aag gaa tgt ccg act cag aat cgc gct tgg aat agc       2898
Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala Trp Asn Ser           
    920                 925                 930                           

tta gaa gtg gag gat ttt gga ttt ggt ctc acc agc act cgg atg ttc       2946
Leu Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr Arg Met Phe           
935                 940                 945                 950           

ctg aag gtc aga gag agc aac aca act gaa tgt gac tcg aag atc att       2994
Leu Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser Lys Ile Ile           
                955                 960                 965               

gga acg gct gtc aag aac aac ttg gcg atc cac agt gac ctg tcc tat       3042
Gly Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp Leu Ser Tyr           
            970                 975                 980                   

tgg att gaa agc agg ctc aat gat acg tgg aag ctt gaa agg gca gtt       3090
Trp Ile Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu Glu Arg Ala Val           
        985                 990                 995                       

ctg ggt  gaa gtc aaa tca tgt  acg tgg cct gag acg  cat acc ttg        3135
Leu Gly  Glu Val Lys Ser Cys  Thr Trp Pro Glu Thr  His Thr Leu            
    1000                 1005                 1010                        

tgg ggc  gat gga atc ctt gag  agt gac ttg ata ata  cca gtc aca        3180
Trp Gly  Asp Gly Ile Leu Glu  Ser Asp Leu Ile Ile  Pro Val Thr            
    1015                 1020                 1025                        

ctg gcg  gga cca cga agc aat  cac aat cgg aga cct  ggg tac aag        3225
Leu Ala  Gly Pro Arg Ser Asn  His Asn Arg Arg Pro  Gly Tyr Lys            
    1030                 1035                 1040                        

aca caa  aac cag ggc cca tgg  gac gaa ggc cgg gta  gag att gac        3270
Thr Gln  Asn Gln Gly Pro Trp  Asp Glu Gly Arg Val  Glu Ile Asp            
    1045                 1050                 1055                        

ttc gat  tac tgc cca gga act  acg gtc acc ctg agt  gag agc tgc        3315
Phe Asp  Tyr Cys Pro Gly Thr  Thr Val Thr Leu Ser  Glu Ser Cys            
    1060                 1065                 1070                        

gga cac  cgt gga cct gcc act  cgc acc acc aca gag  agc gga aag        3360
Gly His  Arg Gly Pro Ala Thr  Arg Thr Thr Thr Glu  Ser Gly Lys            
    1075                 1080                 1085                        

ttg ata  aca gat tgg tgc tgc  agg agc tgc acc tta  cca cca ctg        3405
Leu Ile  Thr Asp Trp Cys Cys  Arg Ser Cys Thr Leu  Pro Pro Leu            
    1090                 1095                 1100                        

cgc tac  caa act gac agc ggc  tgt tgg tat ggt atg  gag atc aga        3450
Arg Tyr  Gln Thr Asp Ser Gly  Cys Trp Tyr Gly Met  Glu Ile Arg            
    1105                 1110                 1115                        

cca cag  aga cat gat gaa aag  acc ctc gtg cag tca  caa gtg aat        3495
Pro Gln  Arg His Asp Glu Lys  Thr Leu Val Gln Ser  Gln Val Asn            
    1120                 1125                 1130                        

gct tat  aat gct gat atg att  gac cct ttt cag ttg  ggc ctt ctg        3540
Ala Tyr  Asn Ala Asp Met Ile  Asp Pro Phe Gln Leu  Gly Leu Leu            
    1135                 1140                 1145                        

gtc gtg  ttc ttg gcc acc cag  gag gtc ctt cgc aag  agg tgg aca        3585
Val Val  Phe Leu Ala Thr Gln  Glu Val Leu Arg Lys  Arg Trp Thr            
    1150                 1155                 1160                        

gcc aag  atc agc atg cca gct  ata ctg att gct ctg  cta gtc ctg        3630
Ala Lys  Ile Ser Met Pro Ala  Ile Leu Ile Ala Leu  Leu Val Leu            
    1165                 1170                 1175                        

gtg ttt  ggg ggc att act tac  act gat gtg tta cgc  tat gtc atc        3675
Val Phe  Gly Gly Ile Thr Tyr  Thr Asp Val Leu Arg  Tyr Val Ile            
    1180                 1185                 1190                        

ttg gtg  ggg gca gct ttc gca  gaa tct aat tcg gga  gga gac gtg        3720
Leu Val  Gly Ala Ala Phe Ala  Glu Ser Asn Ser Gly  Gly Asp Val            
    1195                 1200                 1205                        

gta cac  ttg gcg ctc atg gcg  acc ttc aag ata caa  cca gtg ttt        3765
Val His  Leu Ala Leu Met Ala  Thr Phe Lys Ile Gln  Pro Val Phe            
    1210                 1215                 1220                        

atg gtg  gca tcg ttt ctc aaa  gcg aga tgg acc aac  cag gag aac        3810
Met Val  Ala Ser Phe Leu Lys  Ala Arg Trp Thr Asn  Gln Glu Asn            
    1225                 1230                 1235                        

att ttg  ttg atg ttg gcg gct  gtt ttc ttt caa atg  gct tat tac        3855
Ile Leu  Leu Met Leu Ala Ala  Val Phe Phe Gln Met  Ala Tyr Tyr            
    1240                 1245                 1250                        

gat gcc  cgc caa att ctg ctc  tgg gag atc cct gat  gtg ttg aat        3900
Asp Ala  Arg Gln Ile Leu Leu  Trp Glu Ile Pro Asp  Val Leu Asn            
    1255                 1260                 1265                        

tca ctg  gcg gta gct tgg atg  ata ctg aga gcc ata  aca ttc aca        3945
Ser Leu  Ala Val Ala Trp Met  Ile Leu Arg Ala Ile  Thr Phe Thr            
    1270                 1275                 1280                        

acg aca  tca aac gtg gtt gtt  ccg ctg cta gcc ctg  cta aca ccc        3990
Thr Thr  Ser Asn Val Val Val  Pro Leu Leu Ala Leu  Leu Thr Pro            
    1285                 1290                 1295                        

ggg ctg  aga tgc ttg aat ctg  gat gtg tac agg ata  ctg ctg ttg        4035
Gly Leu  Arg Cys Leu Asn Leu  Asp Val Tyr Arg Ile  Leu Leu Leu            
    1300                 1305                 1310                        

atg gtc  gga ata ggc agc ttg  atc agg gag aag agg  agt gca gct        4080
Met Val  Gly Ile Gly Ser Leu  Ile Arg Glu Lys Arg  Ser Ala Ala            
    1315                 1320                 1325                        

gca aaa  aag aaa gga gca agt  ctg cta tgc ttg gct  cta gcc tca        4125
Ala Lys  Lys Lys Gly Ala Ser  Leu Leu Cys Leu Ala  Leu Ala Ser            
    1330                 1335                 1340                        

aca gga  ctt ttc aac ccc atg  atc ctt gct gct gga  ctg att gca        4170
Thr Gly  Leu Phe Asn Pro Met  Ile Leu Ala Ala Gly  Leu Ile Ala            
    1345                 1350                 1355                        

tgt gat  ccc aac cgt aaa cgc  gga tgg ccc gca act  gaa gtg atg        4215
Cys Asp  Pro Asn Arg Lys Arg  Gly Trp Pro Ala Thr  Glu Val Met            
    1360                 1365                 1370                        

aca gct  gtc ggc cta atg ttt  gcc atc gtc gga ggg  ctg gca gag        4260
Thr Ala  Val Gly Leu Met Phe  Ala Ile Val Gly Gly  Leu Ala Glu            
    1375                 1380                 1385                        

ctt gac  att gac tcc atg gcc  att cca atg act atc  gcg ggg ctc        4305
Leu Asp  Ile Asp Ser Met Ala  Ile Pro Met Thr Ile  Ala Gly Leu            
    1390                 1395                 1400                        

atg ttt  gct gct ttc gtg att  tct ggg aaa tca aca  gat atg tgg        4350
Met Phe  Ala Ala Phe Val Ile  Ser Gly Lys Ser Thr  Asp Met Trp            
    1405                 1410                 1415                        

att gag  aga acg gcg gac att  tcc tgg gaa agt gat  gca gaa att        4395
Ile Glu  Arg Thr Ala Asp Ile  Ser Trp Glu Ser Asp  Ala Glu Ile            
    1420                 1425                 1430                        

aca ggc  tcg agc gaa aga gtt  gat gtg cgg ctt gat  gat gat gga        4440
Thr Gly  Ser Ser Glu Arg Val  Asp Val Arg Leu Asp  Asp Asp Gly            
    1435                 1440                 1445                        

aac ttc  cag ctc atg aat gat  cca gga gca cct tgg  aag ata tgg        4485
Asn Phe  Gln Leu Met Asn Asp  Pro Gly Ala Pro Trp  Lys Ile Trp            
    1450                 1455                 1460                        

atg ctc  aga atg gtc tgt ctc  gcg att agt gcg tac  acc ccc tgg        4530
Met Leu  Arg Met Val Cys Leu  Ala Ile Ser Ala Tyr  Thr Pro Trp            
    1465                 1470                 1475                        

gca atc  ttg ccc tca gta gtt  gga ttt tgg ata act  ctc caa tac        4575
Ala Ile  Leu Pro Ser Val Val  Gly Phe Trp Ile Thr  Leu Gln Tyr            
    1480                 1485                 1490                        

aca aag  aga gga ggc gtg ttg  tgg gac act ccc tca  cca aag gag        4620
Thr Lys  Arg Gly Gly Val Leu  Trp Asp Thr Pro Ser  Pro Lys Glu            
    1495                 1500                 1505                        

tac aaa  aag ggg gac acg acc  acc ggc gtc tac agg  atc atg act        4665
Tyr Lys  Lys Gly Asp Thr Thr  Thr Gly Val Tyr Arg  Ile Met Thr            
    1510                 1515                 1520                        

cgt ggg  ctg ctc ggc agt tat  caa gca gga gcg ggc  gtg atg gtt        4710
Arg Gly  Leu Leu Gly Ser Tyr  Gln Ala Gly Ala Gly  Val Met Val            
    1525                 1530                 1535                        

gaa ggt  gtt ttc cac acc ctt  tgg cat aca aca aaa  gga gcc gct        4755
Glu Gly  Val Phe His Thr Leu  Trp His Thr Thr Lys  Gly Ala Ala            
    1540                 1545                 1550                        

ttg atg  agc gga gag ggc cgc  ctg gac cca tac tgg  ggc agt gtc        4800
Leu Met  Ser Gly Glu Gly Arg  Leu Asp Pro Tyr Trp  Gly Ser Val            
    1555                 1560                 1565                        

aag gag  gat cga ctt tgt tac  gga gga ccc tgg aaa  ttg cag cac        4845
Lys Glu  Asp Arg Leu Cys Tyr  Gly Gly Pro Trp Lys  Leu Gln His            
    1570                 1575                 1580                        

aag tgg  aac ggg cag gat gag  gtg cag atg att gtg  gtg gaa cct        4890
Lys Trp  Asn Gly Gln Asp Glu  Val Gln Met Ile Val  Val Glu Pro            
    1585                 1590                 1595                        

ggc agg  aac gtt aag aac gtc  cag acg aaa cca ggg  gtg ttc aaa        4935
Gly Arg  Asn Val Lys Asn Val  Gln Thr Lys Pro Gly  Val Phe Lys            
    1600                 1605                 1610                        

aca cct  gaa gga gaa atc ggg  gcc gtg act ttg gac  ttc ccc act        4980
Thr Pro  Glu Gly Glu Ile Gly  Ala Val Thr Leu Asp  Phe Pro Thr            
    1615                 1620                 1625                        

gga aca  tca ggc tca cca ata  gtg gac aaa aac ggt  gat gtg att        5025
Gly Thr  Ser Gly Ser Pro Ile  Val Asp Lys Asn Gly  Asp Val Ile            
    1630                 1635                 1640                        

ggg ctt  tat ggc aat gga gtc  ata atg ccc aac ggc  tca tac ata        5070
Gly Leu  Tyr Gly Asn Gly Val  Ile Met Pro Asn Gly  Ser Tyr Ile            
    1645                 1650                 1655                        

agc gcg  ata gtg cag ggt gaa  agg atg gat gag cca  atc cca gcc        5115
Ser Ala  Ile Val Gln Gly Glu  Arg Met Asp Glu Pro  Ile Pro Ala            
    1660                 1665                 1670                        

gga ttc  gaa cct gag atg ctg  agg aaa aaa cag atc  act gta ctg        5160
Gly Phe  Glu Pro Glu Met Leu  Arg Lys Lys Gln Ile  Thr Val Leu            
    1675                 1680                 1685                        

gat ctc  cat ccc ggc gcc ggt  aaa aca agg agg att  ctg cca cag        5205
Asp Leu  His Pro Gly Ala Gly  Lys Thr Arg Arg Ile  Leu Pro Gln            
    1690                 1695                 1700                        

atc atc  aaa gag gcc ata aac  aga aga ctg aga aca  gcc gtg cta        5250
Ile Ile  Lys Glu Ala Ile Asn  Arg Arg Leu Arg Thr  Ala Val Leu            
    1705                 1710                 1715                        

gca cca  acc agg gtt gtg gct  gct gag atg gct gaa  gca ctg aga        5295
Ala Pro  Thr Arg Val Val Ala  Ala Glu Met Ala Glu  Ala Leu Arg            
    1720                 1725                 1730                        

gga ctg  ccc atc cgg tac cag  aca tcc gca gtg ccc  aga gaa cat        5340
Gly Leu  Pro Ile Arg Tyr Gln  Thr Ser Ala Val Pro  Arg Glu His            
    1735                 1740                 1745                        

aat gga  aat gag att gtt gat  gtc atg tgt cat gct  acc ctc acc        5385
Asn Gly  Asn Glu Ile Val Asp  Val Met Cys His Ala  Thr Leu Thr            
    1750                 1755                 1760                        

cac agg  ctg atg tct cct cac  agg gtg ccg aac tac  aac ctg ttc        5430
His Arg  Leu Met Ser Pro His  Arg Val Pro Asn Tyr  Asn Leu Phe            
    1765                 1770                 1775                        

gtg atg  gat gag gct cat ttc  acc gac cca gct agc  att gca gca        5475
Val Met  Asp Glu Ala His Phe  Thr Asp Pro Ala Ser  Ile Ala Ala            
    1780                 1785                 1790                        

aga ggt  tac att tcc aca aag  gtc gag cta ggg gag  gcg gcg gca        5520
Arg Gly  Tyr Ile Ser Thr Lys  Val Glu Leu Gly Glu  Ala Ala Ala            
    1795                 1800                 1805                        

ata ttc  atg aca gcc acc cca  cca ggc act tca gat  cca ttc cca        5565
Ile Phe  Met Thr Ala Thr Pro  Pro Gly Thr Ser Asp  Pro Phe Pro            
    1810                 1815                 1820                        

gag tcc  aat tca cca att tcc  gac tta cag act gag  atc ccg gat        5610
Glu Ser  Asn Ser Pro Ile Ser  Asp Leu Gln Thr Glu  Ile Pro Asp            
    1825                 1830                 1835                        

cga gct  tgg aac tct gga tac  gaa tgg atc aca gaa  tac acc ggg        5655
Arg Ala  Trp Asn Ser Gly Tyr  Glu Trp Ile Thr Glu  Tyr Thr Gly            
    1840                 1845                 1850                        

aag acg  gtt tgg ttt gtg cct  agt gtc aag atg ggg  aat gag att        5700
Lys Thr  Val Trp Phe Val Pro  Ser Val Lys Met Gly  Asn Glu Ile            
    1855                 1860                 1865                        

gcc ctt  tgc cta caa cgt gct  gga aag aaa gta gtc  caa ttg aac        5745
Ala Leu  Cys Leu Gln Arg Ala  Gly Lys Lys Val Val  Gln Leu Asn            
    1870                 1875                 1880                        

aga aag  tcg tac gag acg gag  tac cca aaa tgt aag  aac gat gat        5790
Arg Lys  Ser Tyr Glu Thr Glu  Tyr Pro Lys Cys Lys  Asn Asp Asp            
    1885                 1890                 1895                        

tgg gac  ttt gtt atc aca aca  gac ata tct gaa atg  ggg gct aac        5835
Trp Asp  Phe Val Ile Thr Thr  Asp Ile Ser Glu Met  Gly Ala Asn            
    1900                 1905                 1910                        

ttc aag  gcg agc agg gtg att  gac agc cgg aag agt  gtg aaa cca        5880
Phe Lys  Ala Ser Arg Val Ile  Asp Ser Arg Lys Ser  Val Lys Pro            
    1915                 1920                 1925                        

acc atc  ata aca gaa gga gaa  ggg aga gtg atc ctg  gga gaa cca        5925
Thr Ile  Ile Thr Glu Gly Glu  Gly Arg Val Ile Leu  Gly Glu Pro            
    1930                 1935                 1940                        

tct gca  gtg aca gca gct agt  gcc gcc cag aga cgt  gga cgt atc        5970
Ser Ala  Val Thr Ala Ala Ser  Ala Ala Gln Arg Arg  Gly Arg Ile            
    1945                 1950                 1955                        

ggt aga  aat ccg tcg caa gtt  ggt gat gag tac tgt  tat ggg ggg        6015
Gly Arg  Asn Pro Ser Gln Val  Gly Asp Glu Tyr Cys  Tyr Gly Gly            
    1960                 1965                 1970                        

cac acg  aat gaa gac gac tcg  aac ttc gcc cat tgg  act gag gca        6060
His Thr  Asn Glu Asp Asp Ser  Asn Phe Ala His Trp  Thr Glu Ala            
    1975                 1980                 1985                        

cga atc  atg ctg gac aac atc  aac atg cca aac gga  ctg atc gct        6105
Arg Ile  Met Leu Asp Asn Ile  Asn Met Pro Asn Gly  Leu Ile Ala            
    1990                 1995                 2000                        

caa ttc  tac caa cca gag cgt  gag aag gta tat acc  atg gat ggg        6150
Gln Phe  Tyr Gln Pro Glu Arg  Glu Lys Val Tyr Thr  Met Asp Gly            
    2005                 2010                 2015                        

gaa tac  cgg ctc aga gga gaa  gag aga aaa aac ttt  ctg gaa ctg        6195
Glu Tyr  Arg Leu Arg Gly Glu  Glu Arg Lys Asn Phe  Leu Glu Leu            
    2020                 2025                 2030                        

ttg agg  act gca gat ctg cca  gtt tgg ctg gct tac  aag gtt gca        6240
Leu Arg  Thr Ala Asp Leu Pro  Val Trp Leu Ala Tyr  Lys Val Ala            
    2035                 2040                 2045                        

gcg gct  gga gtg tca tac cac  gac cgg agg tgg tgc  ttt gat ggt        6285
Ala Ala  Gly Val Ser Tyr His  Asp Arg Arg Trp Cys  Phe Asp Gly            
    2050                 2055                 2060                        

cct agg  aca aac aca att tta  gaa gac aac aac gaa  gtg gaa gtc        6330
Pro Arg  Thr Asn Thr Ile Leu  Glu Asp Asn Asn Glu  Val Glu Val            
    2065                 2070                 2075                        

atc acg  aag ctt ggt gaa agg  aag att ctg agg ccg  cgc tgg att        6375
Ile Thr  Lys Leu Gly Glu Arg  Lys Ile Leu Arg Pro  Arg Trp Ile            
    2080                 2085                 2090                        

gac gcc  agg gtg tac tcg gat  cac cag gca cta aag  gcg ttc aag        6420
Asp Ala  Arg Val Tyr Ser Asp  His Gln Ala Leu Lys  Ala Phe Lys            
    2095                 2100                 2105                        

gac ttc  gcc tcg gga aaa cgt  tct cag ata ggg ctc  att gag gtt        6465
Asp Phe  Ala Ser Gly Lys Arg  Ser Gln Ile Gly Leu  Ile Glu Val            
    2110                 2115                 2120                        

ctg gga  aag atg cct gag cac  ttc atg ggg aag aca  tgg gaa gca        6510
Leu Gly  Lys Met Pro Glu His  Phe Met Gly Lys Thr  Trp Glu Ala            
    2125                 2130                 2135                        

ctt gac  acc atg tac gtt gtg  gcc act gca gag aaa  gga gga aga        6555
Leu Asp  Thr Met Tyr Val Val  Ala Thr Ala Glu Lys  Gly Gly Arg            
    2140                 2145                 2150                        

gct cac  aga atg gcc ctg gag  gaa ctg cca gat gct  ctt cag aca        6600
Ala His  Arg Met Ala Leu Glu  Glu Leu Pro Asp Ala  Leu Gln Thr            
    2155                 2160                 2165                        

att gcc  ttg att gcc tta ttg  agt gtg atg acc atg  gga gta ttc        6645
Ile Ala  Leu Ile Ala Leu Leu  Ser Val Met Thr Met  Gly Val Phe            
    2170                 2175                 2180                        

ttc ctc  ctc atg cag cgg aag  ggc att gga aag ata  ggt ttg gga        6690
Phe Leu  Leu Met Gln Arg Lys  Gly Ile Gly Lys Ile  Gly Leu Gly            
    2185                 2190                 2195                        

ggc gct  gtc ttg gga gtc gcg  acc ttt ttc tgt tgg  atg gct gaa        6735
Gly Ala  Val Leu Gly Val Ala  Thr Phe Phe Cys Trp  Met Ala Glu            
    2200                 2205                 2210                        

gtt cca  gga acg aag atc gcc  gga atg ttg ctg ctc  tcc ctt ctc        6780
Val Pro  Gly Thr Lys Ile Ala  Gly Met Leu Leu Leu  Ser Leu Leu            
    2215                 2220                 2225                        

ttg atg  att gtg cta att cct  gag cca gag aag caa  cgt tcg cag        6825
Leu Met  Ile Val Leu Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Gln            
    2230                 2235                 2240                        

aca gac  aac cag cta gcc gtg  ttc ctg att tgt gtc  atg acc ctt        6870
Thr Asp  Asn Gln Leu Ala Val  Phe Leu Ile Cys Val  Met Thr Leu            
    2245                 2250                 2255                        

gtg agc  gca gtg gca gcc aac  gag atg ggt tgg cta  gat aag acc        6915
Val Ser  Ala Val Ala Ala Asn  Glu Met Gly Trp Leu  Asp Lys Thr            
    2260                 2265                 2270                        

aag agt  gac ata agc agt ttg  ttt ggg caa aga att  gag gtc aag        6960
Lys Ser  Asp Ile Ser Ser Leu  Phe Gly Gln Arg Ile  Glu Val Lys            
    2275                 2280                 2285                        

gag aat  ttc agc atg gga gag  ttt ctt ttg gac ttg  agg cct gca        7005
Glu Asn  Phe Ser Met Gly Glu  Phe Leu Leu Asp Leu  Arg Pro Ala            
    2290                 2295                 2300                        

aca gcc  tgg tca ctg tac gct  gtg aca aca gcg gtc  ctc act cca        7050
Thr Ala  Trp Ser Leu Tyr Ala  Val Thr Thr Ala Val  Leu Thr Pro            
    2305                 2310                 2315                        

ctg cta  aag cat ttg atc acg  tca gat tac atc aac  acc tca ttg        7095
Leu Leu  Lys His Leu Ile Thr  Ser Asp Tyr Ile Asn  Thr Ser Leu            
    2320                 2325                 2330                        

acc tca  ata aac gtt cag gca  agt gca cta ttc aca  ctc gcg cga        7140
Thr Ser  Ile Asn Val Gln Ala  Ser Ala Leu Phe Thr  Leu Ala Arg            
    2335                 2340                 2345                        

ggc ttc  ccc ttc gtc gat gtt  gga gtg tcg gct ctc  ctg cta gca        7185
Gly Phe  Pro Phe Val Asp Val  Gly Val Ser Ala Leu  Leu Leu Ala            
    2350                 2355                 2360                        

gcc gga  tgc tgg gga caa gtc  acc ctc acc gtt acg  gta aca gcg        7230
Ala Gly  Cys Trp Gly Gln Val  Thr Leu Thr Val Thr  Val Thr Ala            
    2365                 2370                 2375                        

gca aca  ctc ctt ttt tgc cac  tat gcc tac atg gtt  ccc ggt tgg        7275
Ala Thr  Leu Leu Phe Cys His  Tyr Ala Tyr Met Val  Pro Gly Trp            
    2380                 2385                 2390                        

caa gct  gag gca atg cgc tca  gcc cag cgg cgg aca  gcg gcc gga        7320
Gln Ala  Glu Ala Met Arg Ser  Ala Gln Arg Arg Thr  Ala Ala Gly            
    2395                 2400                 2405                        

atc atg  aag aac gct gta gtg  gat ggc atc gtg gcc  acg gac gtc        7365
Ile Met  Lys Asn Ala Val Val  Asp Gly Ile Val Ala  Thr Asp Val            
    2410                 2415                 2420                        

cca gaa  tta gag cgc acc aca  ccc atc atg cag aag  aaa gtt gga        7410
Pro Glu  Leu Glu Arg Thr Thr  Pro Ile Met Gln Lys  Lys Val Gly            
    2425                 2430                 2435                        

cag atc  atg ctg atc ttg gtg  tct cta gct gca gta  gta gtg aac        7455
Gln Ile  Met Leu Ile Leu Val  Ser Leu Ala Ala Val  Val Val Asn            
    2440                 2445                 2450                        

ccg tct  gtg aag aca gta cga  gaa gcc gga att ttg  atc acg gcc        7500
Pro Ser  Val Lys Thr Val Arg  Glu Ala Gly Ile Leu  Ile Thr Ala            
    2455                 2460                 2465                        

gca gcg  gtg acg ctt tgg gag  aat gga gca agc tct  gtt tgg aac        7545
Ala Ala  Val Thr Leu Trp Glu  Asn Gly Ala Ser Ser  Val Trp Asn            
    2470                 2475                 2480                        

gca aca  act gcc atc gga ctc  tgc cac atc atg cgt  ggg ggt tgg        7590
Ala Thr  Thr Ala Ile Gly Leu  Cys His Ile Met Arg  Gly Gly Trp            
    2485                 2490                 2495                        

ttg tca  tgt cta tcc ata aca  tgg aca ctc ata aag  aac atg gaa        7635
Leu Ser  Cys Leu Ser Ile Thr  Trp Thr Leu Ile Lys  Asn Met Glu            
    2500                 2505                 2510                        

aaa cca  gga cta aaa aga ggt  ggg gca aaa gga cgc  acc ttg gga        7680
Lys Pro  Gly Leu Lys Arg Gly  Gly Ala Lys Gly Arg  Thr Leu Gly            
    2515                 2520                 2525                        

gag gtt  tgg aaa gaa aga ctc  aac cag atg aca aaa  gaa gag ttc        7725
Glu Val  Trp Lys Glu Arg Leu  Asn Gln Met Thr Lys  Glu Glu Phe            
    2530                 2535                 2540                        

act agg  tac cgc aaa gag gcc  atc atc gaa gtc gat  cgc tca gcg        7770
Thr Arg  Tyr Arg Lys Glu Ala  Ile Ile Glu Val Asp  Arg Ser Ala            
    2545                 2550                 2555                        

gca aaa  cac gcc agg aaa gaa  ggc aat gtc act gga  ggg cat cca        7815
Ala Lys  His Ala Arg Lys Glu  Gly Asn Val Thr Gly  Gly His Pro            
    2560                 2565                 2570                        

gtc tct  agg ggc aca gca aaa  ctg aga tgg ctg gtc  gaa cgg agg        7860
Val Ser  Arg Gly Thr Ala Lys  Leu Arg Trp Leu Val  Glu Arg Arg            
    2575                 2580                 2585                        

ttt ctc  gaa ccg gtc gga aaa  gtg att gac ctt gga  tgt gga aga        7905
Phe Leu  Glu Pro Val Gly Lys  Val Ile Asp Leu Gly  Cys Gly Arg            
    2590                 2595                 2600                        

ggc ggt  tgg tgt tac tat atg  gca acc caa aaa aga  gtc caa gaa        7950
Gly Gly  Trp Cys Tyr Tyr Met  Ala Thr Gln Lys Arg  Val Gln Glu            
    2605                 2610                 2615                        

gtc aga  ggg tac aca aag ggc  ggt ccc gga cat gaa  gag ccc caa        7995
Val Arg  Gly Tyr Thr Lys Gly  Gly Pro Gly His Glu  Glu Pro Gln            
    2620                 2625                 2630                        

cta gtg  caa agt tat gga tgg  aac att gtc acc atg  aag agt gga        8040
Leu Val  Gln Ser Tyr Gly Trp  Asn Ile Val Thr Met  Lys Ser Gly            
    2635                 2640                 2645                        

gtg gat  gtg ttc tac aga cct  tct gag tgt tgt gac  acc ctc ctt        8085
Val Asp  Val Phe Tyr Arg Pro  Ser Glu Cys Cys Asp  Thr Leu Leu            
    2650                 2655                 2660                        

tgt gac  atc gga gag tcc tcg  tca agt gct gag gtt  gaa gag cat        8130
Cys Asp  Ile Gly Glu Ser Ser  Ser Ser Ala Glu Val  Glu Glu His            
    2665                 2670                 2675                        

agg acg  att cgg gtc ctt gaa  atg gtt gag gac tgg  ctg cac cga        8175
Arg Thr  Ile Arg Val Leu Glu  Met Val Glu Asp Trp  Leu His Arg            
    2680                 2685                 2690                        

ggg cca  agg gaa ttt tgc gtg  aag gtg ctc tgc ccc  tac atg ccg        8220
Gly Pro  Arg Glu Phe Cys Val  Lys Val Leu Cys Pro  Tyr Met Pro            
    2695                 2700                 2705                        

aaa gtc  ata gag aag atg gag  ctg ctc caa cgc cgg  tat ggg ggg        8265
Lys Val  Ile Glu Lys Met Glu  Leu Leu Gln Arg Arg  Tyr Gly Gly            
    2710                 2715                 2720                        

gga ctg  gtc aga aac cca ctc  tca cgg aat tcc acg  cac gag atg        8310
Gly Leu  Val Arg Asn Pro Leu  Ser Arg Asn Ser Thr  His Glu Met            
    2725                 2730                 2735                        

tat tgg  gtg agt cga gct tca  ggc aat gtg gta cat  tca gtg aat        8355
Tyr Trp  Val Ser Arg Ala Ser  Gly Asn Val Val His  Ser Val Asn            
    2740                 2745                 2750                        

atg acc  agc cag gtg ctc cta  gga aga atg gaa aaa  agg acc tgg        8400
Met Thr  Ser Gln Val Leu Leu  Gly Arg Met Glu Lys  Arg Thr Trp            
    2755                 2760                 2765                        

aag gga  ccc caa tac gag gaa  gat gta aac ttg gga  agt gga acc        8445
Lys Gly  Pro Gln Tyr Glu Glu  Asp Val Asn Leu Gly  Ser Gly Thr            
    2770                 2775                 2780                        

agg gcg  gtg gga aaa ccc ctg  ctc aac tca gac acc  agt aaa atc        8490
Arg Ala  Val Gly Lys Pro Leu  Leu Asn Ser Asp Thr  Ser Lys Ile            
    2785                 2790                 2795                        

aag aac  agg att gaa cga ctc  agg cgt gag tac agt  tcg acg tgg        8535
Lys Asn  Arg Ile Glu Arg Leu  Arg Arg Glu Tyr Ser  Ser Thr Trp            
    2800                 2805                 2810                        

cac cac  gat gag aac cac cca  tat aga acc tgg aac  tat cac ggc        8580
His His  Asp Glu Asn His Pro  Tyr Arg Thr Trp Asn  Tyr His Gly            
    2815                 2820                 2825                        

agt tat  gat gtg aag ccc aca  ggc tcc gcc agt tcg  ctg gtc aat        8625
Ser Tyr  Asp Val Lys Pro Thr  Gly Ser Ala Ser Ser  Leu Val Asn            
    2830                 2835                 2840                        

gga gtg  gtc agg ctc ctc tca  aaa cca tgg gac acc  atc acg aat        8670
Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp Asp Thr  Ile Thr Asn            
    2845                 2850                 2855                        

gtt acc  acc atg gcc atg act  gac act act ccc ttc  ggg cag cag        8715
Val Thr  Thr Met Ala Met Thr  Asp Thr Thr Pro Phe  Gly Gln Gln            
    2860                 2865                 2870                        

cga gtg  ttc aaa gag aag gtg  gac acg aaa gct cct  gaa ccg cca        8760
Arg Val  Phe Lys Glu Lys Val  Asp Thr Lys Ala Pro  Glu Pro Pro            
    2875                 2880                 2885                        

gaa gga  gtg aag tac gtg ctc  aac gag acc acc aac  tgg ttg tgg        8805
Glu Gly  Val Lys Tyr Val Leu  Asn Glu Thr Thr Asn  Trp Leu Trp            
    2890                 2895                 2900                        

gcg ttt  ttg gcc aga gaa aaa  cgt ccc aga atg tgc  tct cga gag        8850
Ala Phe  Leu Ala Arg Glu Lys  Arg Pro Arg Met Cys  Ser Arg Glu            
    2905                 2910                 2915                        

gaa ttc  ata aga aag gtc aac  agc aat gca gct ttg  ggt gcc atg        8895
Glu Phe  Ile Arg Lys Val Asn  Ser Asn Ala Ala Leu  Gly Ala Met            
    2920                 2925                 2930                        

ttt gaa  gag cag aat caa tgg  agg agc gcc aga gaa  gca gtt gaa        8940
Phe Glu  Glu Gln Asn Gln Trp  Arg Ser Ala Arg Glu  Ala Val Glu            
    2935                 2940                 2945                        

gat cca  aaa ttt tgg gag atg  gtg gat gag gag cgc  gag gca cat        8985
Asp Pro  Lys Phe Trp Glu Met  Val Asp Glu Glu Arg  Glu Ala His            
    2950                 2955                 2960                        

ctg cgg  ggg gaa tgt cac act  tgc att tac aac atg  atg gga aag        9030
Leu Arg  Gly Glu Cys His Thr  Cys Ile Tyr Asn Met  Met Gly Lys            
    2965                 2970                 2975                        

aga gag  aaa aaa ccc gga gag  ttc gga aag gcc aag  gga agc aga        9075
Arg Glu  Lys Lys Pro Gly Glu  Phe Gly Lys Ala Lys  Gly Ser Arg            
    2980                 2985                 2990                        

gcc att  tgg ttc atg tgg ctc  gga gct cgc ttt ctg  gag ttc gag        9120
Ala Ile  Trp Phe Met Trp Leu  Gly Ala Arg Phe Leu  Glu Phe Glu            
    2995                 3000                 3005                        

gct ctg  ggt ttt ctc aat gaa  gac cac tgg ctt gga  aga aag aac        9165
Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp Leu Gly  Arg Lys Asn            
    3010                 3015                 3020                        

tca gga  gga ggt gtc gag ggc  ttg ggc ctc caa aaa  ctg ggt tac        9210
Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu Gln Lys  Leu Gly Tyr            
    3025                 3030                 3035                        

atc ctg  cgt gaa gtt ggc acc  cgg cct ggg ggc aag  atc tat gct        9255
Ile Leu  Arg Glu Val Gly Thr  Arg Pro Gly Gly Lys  Ile Tyr Ala            
    3040                 3045                 3050                        

gat gac  aca gct ggc tgg gac  acc cgc atc acg aga  gct gac ttg        9300
Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile Thr Arg  Ala Asp Leu            
    3055                 3060                 3065                        

gaa aat  gaa gct aag gtg ctt  gag ctg ctt gat ggg  gaa cat cgg        9345
Glu Asn  Glu Ala Lys Val Leu  Glu Leu Leu Asp Gly  Glu His Arg            
    3070                 3075                 3080                        

cgt ctt  gcc agg gcc atc att  gag ctc acc tat cgt  cac aaa gtt        9390
Arg Leu  Ala Arg Ala Ile Ile  Glu Leu Thr Tyr Arg  His Lys Val            
    3085                 3090                 3095                        

gtg aaa  gtg atg cgc ccg gct  gct gat gga aga acc  gtc atg gat        9435
Val Lys  Val Met Arg Pro Ala  Ala Asp Gly Arg Thr  Val Met Asp            
    3100                 3105                 3110                        

gtt atc  tcc aga gaa gat cag  agg ggg agt gga caa  gtt gtc acc        9480
Val Ile  Ser Arg Glu Asp Gln  Arg Gly Ser Gly Gln  Val Val Thr            
    3115                 3120                 3125                        

tac gcc  cta aac act ttc acc  aac ctg gcc gtc cag  ctg gtg agg        9525
Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Ala Val Gln  Leu Val Arg            
    3130                 3135                 3140                        

atg atg  gaa ggg gaa gga gtg  att ggc cca gat gat  gtg gag aaa        9570
Met Met  Glu Gly Glu Gly Val  Ile Gly Pro Asp Asp  Val Glu Lys            
    3145                 3150                 3155                        

ctc aca  aaa ggg aaa gga ccc  aaa gtc agg acc tgg  ctg ttt gag        9615
Leu Thr  Lys Gly Lys Gly Pro  Lys Val Arg Thr Trp  Leu Phe Glu            
    3160                 3165                 3170                        

aat ggg  gaa gaa aga ctc agc  cgc atg gct gtc agt  gga gat gac        9660
Asn Gly  Glu Glu Arg Leu Ser  Arg Met Ala Val Ser  Gly Asp Asp            
    3175                 3180                 3185                        

tgt gtg  gta aag ccc ctg gac  gat cgc ttt gcc acc  tcg ctc cac        9705
Cys Val  Val Lys Pro Leu Asp  Asp Arg Phe Ala Thr  Ser Leu His            
    3190                 3195                 3200                        

ttc ctc  aat gct atg tca aag  gtt cgc aaa gac atc  caa gag tgg        9750
Phe Leu  Asn Ala Met Ser Lys  Val Arg Lys Asp Ile  Gln Glu Trp            
    3205                 3210                 3215                        

aaa ccg  tca act gga tgg tat  gat tgg cag cag gtt  cca ttt tgc        9795
Lys Pro  Ser Thr Gly Trp Tyr  Asp Trp Gln Gln Val  Pro Phe Cys            
    3220                 3225                 3230                        

tca aac  cat ttc act gaa ttg  atc atg aaa gat gga  aga aca ctg        9840
Ser Asn  His Phe Thr Glu Leu  Ile Met Lys Asp Gly  Arg Thr Leu            
    3235                 3240                 3245                        

gtg gtt  cca tgc cga gga cag  gat gaa ttg gta ggc  aga gct cgc        9885
Val Val  Pro Cys Arg Gly Gln  Asp Glu Leu Val Gly  Arg Ala Arg            
    3250                 3255                 3260                        

ata tct  cca ggg gcc gga tgg  aac gtc cgc gac act  gct tgt ctg        9930
Ile Ser  Pro Gly Ala Gly Trp  Asn Val Arg Asp Thr  Ala Cys Leu            
    3265                 3270                 3275                        

gct aag  tct tat gcc cag atg  tgg ctg ctt ctg tac  ttc cac aga        9975
Ala Lys  Ser Tyr Ala Gln Met  Trp Leu Leu Leu Tyr  Phe His Arg            
    3280                 3285                 3290                        

aga gac  ctg cgg ctc atg gcc  aac gcc att tgc tcc  gct gtc cct       10020
Arg Asp  Leu Arg Leu Met Ala  Asn Ala Ile Cys Ser  Ala Val Pro            
    3295                 3300                 3305                        

gtg aat  tgg gtc cct acc gga  aga acc acg tgg tcc  atc cat gca       10065
Val Asn  Trp Val Pro Thr Gly  Arg Thr Thr Trp Ser  Ile His Ala            
    3310                 3315                 3320                        

gga gga  gag tgg atg aca aca  gag gac atg ttg gag  gtc tgg aac       10110
Gly Gly  Glu Trp Met Thr Thr  Glu Asp Met Leu Glu  Val Trp Asn            
    3325                 3330                 3335                        

cgt gtt  tgg ata gag gag aat  gaa tgg atg gaa gac  aaa acc cca       10155
Arg Val  Trp Ile Glu Glu Asn  Glu Trp Met Glu Asp  Lys Thr Pro            
    3340                 3345                 3350                        

gtg gag  aaa tgg agt gac gtc  cca tat tca gga aaa  cga gag gac       10200
Val Glu  Lys Trp Ser Asp Val  Pro Tyr Ser Gly Lys  Arg Glu Asp            
    3355                 3360                 3365                        

atc tgg  tgt ggc agc ctg att  ggc aca aga gcc cga  gcc acg tgg       10245
Ile Trp  Cys Gly Ser Leu Ile  Gly Thr Arg Ala Arg  Ala Thr Trp            
    3370                 3375                 3380                        

gca gaa  aac atc cag gtg gct  atc aac caa gtc aga  gca atc atc       10290
Ala Glu  Asn Ile Gln Val Ala  Ile Asn Gln Val Arg  Ala Ile Ile            
    3385                 3390                 3395                        

gga gat  gag aag tat gtg gat  tac atg agt tca cta  aag aga tat       10335
Gly Asp  Glu Lys Tyr Val Asp  Tyr Met Ser Ser Leu  Lys Arg Tyr            
    3400                 3405                 3410                        

gaa gac  aca act ttg gtt gag  gac aca gta ctg tag atatttaatc         10381
Glu Asp  Thr Thr Leu Val Glu  Asp Thr Val Leu                             
    3415                 3420                                             

aattgtaaat agacaatata agtatgcata aaagtgtagt tttatagtag tatttagtgg    10441

tgttagtgta aatagttaag aaaattttga ggagaaagtc aggccgggaa gttcccgcca    10501

ccggaagttg agtagacggt gctgcctgcg actcaacccc aggaggactg ggtgaacaaa    10561

gccgcgaagt gatccatgta agccctcaga accgtctcgg aaggaggacc ccacatgttg    10621

taacttcaaa gcccaatgtc agaccacgct acggcgtgct actctgcgga gagtgcagtc    10681

tgcgatagtg ccccaggagg actgggttaa caaaggcaaa ccaacgcccc acgcggccct    10741

agccccggta atggtgttaa ccagggcgaa aggactagag gttagaggag accccgcggt    10801

ttaaagtgca cggcccagcc tggctgaagc tgtaggtcag gggaaggact agaggttagt    10861

ggagaccccg tgccacaaaa caccacaaca aaacagcata ttgacacctg ggatagacta    10921

ggagatcttc tgctctgcac aaccagccac acggcacagt gcgccgacaa tggtggctgg    10981

tggtgcgaga acacaggatc t                                              11002


<210>  18
<211>  3424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala 
            100                 105                 110         


Val Met Ile Gly Leu Ile Ala Ser Val Gly Ala Phe His Leu Thr Ser 
        115                 120                 125             


Arg Asp Gly Glu Pro Arg Met Ile Val Gly Lys Asn Glu Arg Gly Lys 
    130                 135                 140                 


Ser Leu Leu Phe Lys Thr Ala Ser Gly Ile Asn Met Cys Thr Leu Ile 
145                 150                 155                 160 


Ala Met Asp Leu Gly Glu Met Cys Asp Asp Thr Val Thr Tyr Lys Cys 
                165                 170                 175     


Pro His Ile Thr Glu Val Glu Pro Glu Asp Ile Asp Cys Trp Cys Asn 
            180                 185                 190         


Leu Thr Ser Thr Trp Val Thr Tyr Gly Thr Cys Asn Gln Ala Gly Glu 
        195                 200                 205             


His Arg Arg Asp Lys Arg Ser Val Ala Leu Ala Pro His Val Gly Met 
    210                 215                 220                 


Gly Leu Asp Thr Arg Thr Gln Thr Trp Met Ser Ala Glu Gly Ala Trp 
225                 230                 235                 240 


Arg Gln Val Glu Lys Val Glu Thr Trp Ala Leu Arg His Pro Gly Phe 
                245                 250                 255     


Thr Ile Leu Ala Leu Phe Leu Ala His Tyr Ile Gly Thr Ser Leu Thr 
            260                 265                 270         


Gln Lys Val Val Ile Phe Ile Leu Leu Met Leu Val Thr Pro Ser Met 
        275                 280                 285             


Thr Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Leu 
    290                 295                 300                 


Ser Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val 
305                 310                 315                 320 


Thr Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Gln Lys 
                325                 330                 335     


Thr Glu Ala Thr Gln Leu Ala Thr Leu Arg Lys Leu Cys Ile Glu Gly 
            340                 345                 350         


Lys Ile Thr Asn Ile Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu 
        355                 360                 365             


Ala Ile Leu Pro Glu Glu Gln Asp Gln Asn Tyr Val Cys Lys His Thr 
    370                 375                 380                 


Tyr Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly 
385                 390                 395                 400 


Ser Leu Val Thr Cys Ala Lys Phe Gln Cys Leu Glu Ser Ile Glu Gly 
                405                 410                 415     


Lys Val Val Gln His Glu Asn Leu Lys Tyr Thr Val Ile Ile Thr Val 
            420                 425                 430         


His Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Gln Gly Val Thr 
        435                 440                 445             


Ala Glu Ile Thr Pro Gln Ala Ser Thr Ala Glu Ala Ile Leu Pro Glu 
    450                 455                 460                 


Tyr Gly Thr Leu Gly Leu Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe 
465                 470                 475                 480 


Asn Glu Met Ile Ser Leu Thr Met Lys Asn Lys Ala Trp Met Val His 
                485                 490                 495     


Arg Gln Trp Phe Phe Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala Thr 
            500                 505                 510         


Ala Glu Thr Pro Thr Trp Asn Arg Lys Glu Leu Leu Val Thr Phe Lys 
        515                 520                 525             


Asn Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln Glu 
    530                 535                 540                 


Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr Ser 
545                 550                 555                 560 


Gly Gly Thr Ser Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys Met 
                565                 570                 575     


Asp Lys Leu Glu Leu Lys Gly Met Ser Tyr Ala Met Cys Leu Ser Ser 
            580                 585                 590         


Phe Val Leu Lys Lys Glu Val Ser Glu Thr Gln His Gly Thr Ile Leu 
        595                 600                 605             


Ile Lys Val Glu Tyr Lys Gly Glu Asp Ala Pro Cys Lys Ile Pro Phe 
    610                 615                 620                 


Ser Thr Glu Asp Gly Gln Gly Lys Ala Leu Asn Gly Arg Leu Ile Thr 
625                 630                 635                 640 


Ala Asn Pro Val Val Thr Lys Lys Glu Glu Pro Val Asn Ile Glu Ala 
                645                 650                 655     


Glu Pro Pro Phe Gly Glu Ser Asn Ile Val Ile Gly Ile Gly Asp Lys 
            660                 665                 670         


Ala Leu Lys Ile Asn Trp Tyr Lys Lys Gly Ser Ser Ile Gly Lys Met 
        675                 680                 685             


Phe Glu Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly Asp 
    690                 695                 700                 


Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Leu Asn Ser Leu Gly 
705                 710                 715                 720 


Lys Met Val His Gln Ile Phe Gly Ser Ala Tyr Thr Ala Leu Phe Gly 
                725                 730                 735     


Gly Val Ser Trp Met Met Lys Ile Gly Ile Gly Val Leu Leu Thr Trp 
            740                 745                 750         


Ile Gly Leu Asn Ser Lys Asn Thr Ser Met Ser Phe Ser Cys Ile Ala 
        755                 760                 765             


Ile Gly Ile Ile Thr Leu Tyr Leu Gly Ala Val Val Gln Ala Asp Ser 
    770                 775                 780                 


Gly Cys Ala Ile Asp Ile Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly 
785                 790                 795                 800 


Val Phe Ile His Asn Asp Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr 
                805                 810                 815     


Tyr Pro Glu Thr Pro Gln Gly Leu Ala Lys Ile Ile Gln Lys Ala His 
            820                 825                 830         


Lys Glu Gly Val Cys Gly Leu Arg Ser Val Ser Arg Leu Glu His Gln 
        835                 840                 845             


Met Trp Glu Ala Val Lys Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn 
    850                 855                 860                 


Gly Val Asp Leu Ser Val Val Val Glu Lys Gln Glu Gly Met Tyr Lys 
865                 870                 875                 880 


Ser Ala Pro Lys Arg Leu Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly 
                885                 890                 895     


Trp Lys Ala Trp Gly Lys Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn 
            900                 905                 910         


Asn Thr Phe Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln 
        915                 920                 925             


Asn Arg Ala Trp Asn Ser Leu Glu Val Glu Asp Phe Gly Phe Gly Leu 
    930                 935                 940                 


Thr Ser Thr Arg Met Phe Leu Lys Val Arg Glu Ser Asn Thr Thr Glu 
945                 950                 955                 960 


Cys Asp Ser Lys Ile Ile Gly Thr Ala Val Lys Asn Asn Leu Ala Ile 
                965                 970                 975     


His Ser Asp Leu Ser Tyr Trp Ile Glu Ser Arg Leu Asn Asp Thr Trp 
            980                 985                 990         


Lys Leu Glu Arg Ala Val Leu Gly  Glu Val Lys Ser Cys  Thr Trp Pro 
        995                 1000                 1005             


Glu Thr  His Thr Leu Trp Gly  Asp Gly Ile Leu Glu  Ser Asp Leu 
    1010                 1015                 1020             


Ile Ile  Pro Val Thr Leu Ala  Gly Pro Arg Ser Asn  His Asn Arg 
    1025                 1030                 1035             


Arg Pro  Gly Tyr Lys Thr Gln  Asn Gln Gly Pro Trp  Asp Glu Gly 
    1040                 1045                 1050             


Arg Val  Glu Ile Asp Phe Asp  Tyr Cys Pro Gly Thr  Thr Val Thr 
    1055                 1060                 1065             


Leu Ser  Glu Ser Cys Gly His  Arg Gly Pro Ala Thr  Arg Thr Thr 
    1070                 1075                 1080             


Thr Glu  Ser Gly Lys Leu Ile  Thr Asp Trp Cys Cys  Arg Ser Cys 
    1085                 1090                 1095             


Thr Leu  Pro Pro Leu Arg Tyr  Gln Thr Asp Ser Gly  Cys Trp Tyr 
    1100                 1105                 1110             


Gly Met  Glu Ile Arg Pro Gln  Arg His Asp Glu Lys  Thr Leu Val 
    1115                 1120                 1125             


Gln Ser  Gln Val Asn Ala Tyr  Asn Ala Asp Met Ile  Asp Pro Phe 
    1130                 1135                 1140             


Gln Leu  Gly Leu Leu Val Val  Phe Leu Ala Thr Gln  Glu Val Leu 
    1145                 1150                 1155             


Arg Lys  Arg Trp Thr Ala Lys  Ile Ser Met Pro Ala  Ile Leu Ile 
    1160                 1165                 1170             


Ala Leu  Leu Val Leu Val Phe  Gly Gly Ile Thr Tyr  Thr Asp Val 
    1175                 1180                 1185             


Leu Arg  Tyr Val Ile Leu Val  Gly Ala Ala Phe Ala  Glu Ser Asn 
    1190                 1195                 1200             


Ser Gly  Gly Asp Val Val His  Leu Ala Leu Met Ala  Thr Phe Lys 
    1205                 1210                 1215             


Ile Gln  Pro Val Phe Met Val  Ala Ser Phe Leu Lys  Ala Arg Trp 
    1220                 1225                 1230             


Thr Asn  Gln Glu Asn Ile Leu  Leu Met Leu Ala Ala  Val Phe Phe 
    1235                 1240                 1245             


Gln Met  Ala Tyr Tyr Asp Ala  Arg Gln Ile Leu Leu  Trp Glu Ile 
    1250                 1255                 1260             


Pro Asp  Val Leu Asn Ser Leu  Ala Val Ala Trp Met  Ile Leu Arg 
    1265                 1270                 1275             


Ala Ile  Thr Phe Thr Thr Thr  Ser Asn Val Val Val  Pro Leu Leu 
    1280                 1285                 1290             


Ala Leu  Leu Thr Pro Gly Leu  Arg Cys Leu Asn Leu  Asp Val Tyr 
    1295                 1300                 1305             


Arg Ile  Leu Leu Leu Met Val  Gly Ile Gly Ser Leu  Ile Arg Glu 
    1310                 1315                 1320             


Lys Arg  Ser Ala Ala Ala Lys  Lys Lys Gly Ala Ser  Leu Leu Cys 
    1325                 1330                 1335             


Leu Ala  Leu Ala Ser Thr Gly  Leu Phe Asn Pro Met  Ile Leu Ala 
    1340                 1345                 1350             


Ala Gly  Leu Ile Ala Cys Asp  Pro Asn Arg Lys Arg  Gly Trp Pro 
    1355                 1360                 1365             


Ala Thr  Glu Val Met Thr Ala  Val Gly Leu Met Phe  Ala Ile Val 
    1370                 1375                 1380             


Gly Gly  Leu Ala Glu Leu Asp  Ile Asp Ser Met Ala  Ile Pro Met 
    1385                 1390                 1395             


Thr Ile  Ala Gly Leu Met Phe  Ala Ala Phe Val Ile  Ser Gly Lys 
    1400                 1405                 1410             


Ser Thr  Asp Met Trp Ile Glu  Arg Thr Ala Asp Ile  Ser Trp Glu 
    1415                 1420                 1425             


Ser Asp  Ala Glu Ile Thr Gly  Ser Ser Glu Arg Val  Asp Val Arg 
    1430                 1435                 1440             


Leu Asp  Asp Asp Gly Asn Phe  Gln Leu Met Asn Asp  Pro Gly Ala 
    1445                 1450                 1455             


Pro Trp  Lys Ile Trp Met Leu  Arg Met Val Cys Leu  Ala Ile Ser 
    1460                 1465                 1470             


Ala Tyr  Thr Pro Trp Ala Ile  Leu Pro Ser Val Val  Gly Phe Trp 
    1475                 1480                 1485             


Ile Thr  Leu Gln Tyr Thr Lys  Arg Gly Gly Val Leu  Trp Asp Thr 
    1490                 1495                 1500             


Pro Ser  Pro Lys Glu Tyr Lys  Lys Gly Asp Thr Thr  Thr Gly Val 
    1505                 1510                 1515             


Tyr Arg  Ile Met Thr Arg Gly  Leu Leu Gly Ser Tyr  Gln Ala Gly 
    1520                 1525                 1530             


Ala Gly  Val Met Val Glu Gly  Val Phe His Thr Leu  Trp His Thr 
    1535                 1540                 1545             


Thr Lys  Gly Ala Ala Leu Met  Ser Gly Glu Gly Arg  Leu Asp Pro 
    1550                 1555                 1560             


Tyr Trp  Gly Ser Val Lys Glu  Asp Arg Leu Cys Tyr  Gly Gly Pro 
    1565                 1570                 1575             


Trp Lys  Leu Gln His Lys Trp  Asn Gly Gln Asp Glu  Val Gln Met 
    1580                 1585                 1590             


Ile Val  Val Glu Pro Gly Arg  Asn Val Lys Asn Val  Gln Thr Lys 
    1595                 1600                 1605             


Pro Gly  Val Phe Lys Thr Pro  Glu Gly Glu Ile Gly  Ala Val Thr 
    1610                 1615                 1620             


Leu Asp  Phe Pro Thr Gly Thr  Ser Gly Ser Pro Ile  Val Asp Lys 
    1625                 1630                 1635             


Asn Gly  Asp Val Ile Gly Leu  Tyr Gly Asn Gly Val  Ile Met Pro 
    1640                 1645                 1650             


Asn Gly  Ser Tyr Ile Ser Ala  Ile Val Gln Gly Glu  Arg Met Asp 
    1655                 1660                 1665             


Glu Pro  Ile Pro Ala Gly Phe  Glu Pro Glu Met Leu  Arg Lys Lys 
    1670                 1675                 1680             


Gln Ile  Thr Val Leu Asp Leu  His Pro Gly Ala Gly  Lys Thr Arg 
    1685                 1690                 1695             


Arg Ile  Leu Pro Gln Ile Ile  Lys Glu Ala Ile Asn  Arg Arg Leu 
    1700                 1705                 1710             


Arg Thr  Ala Val Leu Ala Pro  Thr Arg Val Val Ala  Ala Glu Met 
    1715                 1720                 1725             


Ala Glu  Ala Leu Arg Gly Leu  Pro Ile Arg Tyr Gln  Thr Ser Ala 
    1730                 1735                 1740             


Val Pro  Arg Glu His Asn Gly  Asn Glu Ile Val Asp  Val Met Cys 
    1745                 1750                 1755             


His Ala  Thr Leu Thr His Arg  Leu Met Ser Pro His  Arg Val Pro 
    1760                 1765                 1770             


Asn Tyr  Asn Leu Phe Val Met  Asp Glu Ala His Phe  Thr Asp Pro 
    1775                 1780                 1785             


Ala Ser  Ile Ala Ala Arg Gly  Tyr Ile Ser Thr Lys  Val Glu Leu 
    1790                 1795                 1800             


Gly Glu  Ala Ala Ala Ile Phe  Met Thr Ala Thr Pro  Pro Gly Thr 
    1805                 1810                 1815             


Ser Asp  Pro Phe Pro Glu Ser  Asn Ser Pro Ile Ser  Asp Leu Gln 
    1820                 1825                 1830             


Thr Glu  Ile Pro Asp Arg Ala  Trp Asn Ser Gly Tyr  Glu Trp Ile 
    1835                 1840                 1845             


Thr Glu  Tyr Thr Gly Lys Thr  Val Trp Phe Val Pro  Ser Val Lys 
    1850                 1855                 1860             


Met Gly  Asn Glu Ile Ala Leu  Cys Leu Gln Arg Ala  Gly Lys Lys 
    1865                 1870                 1875             


Val Val  Gln Leu Asn Arg Lys  Ser Tyr Glu Thr Glu  Tyr Pro Lys 
    1880                 1885                 1890             


Cys Lys  Asn Asp Asp Trp Asp  Phe Val Ile Thr Thr  Asp Ile Ser 
    1895                 1900                 1905             


Glu Met  Gly Ala Asn Phe Lys  Ala Ser Arg Val Ile  Asp Ser Arg 
    1910                 1915                 1920             


Lys Ser  Val Lys Pro Thr Ile  Ile Thr Glu Gly Glu  Gly Arg Val 
    1925                 1930                 1935             


Ile Leu  Gly Glu Pro Ser Ala  Val Thr Ala Ala Ser  Ala Ala Gln 
    1940                 1945                 1950             


Arg Arg  Gly Arg Ile Gly Arg  Asn Pro Ser Gln Val  Gly Asp Glu 
    1955                 1960                 1965             


Tyr Cys  Tyr Gly Gly His Thr  Asn Glu Asp Asp Ser  Asn Phe Ala 
    1970                 1975                 1980             


His Trp  Thr Glu Ala Arg Ile  Met Leu Asp Asn Ile  Asn Met Pro 
    1985                 1990                 1995             


Asn Gly  Leu Ile Ala Gln Phe  Tyr Gln Pro Glu Arg  Glu Lys Val 
    2000                 2005                 2010             


Tyr Thr  Met Asp Gly Glu Tyr  Arg Leu Arg Gly Glu  Glu Arg Lys 
    2015                 2020                 2025             


Asn Phe  Leu Glu Leu Leu Arg  Thr Ala Asp Leu Pro  Val Trp Leu 
    2030                 2035                 2040             


Ala Tyr  Lys Val Ala Ala Ala  Gly Val Ser Tyr His  Asp Arg Arg 
    2045                 2050                 2055             


Trp Cys  Phe Asp Gly Pro Arg  Thr Asn Thr Ile Leu  Glu Asp Asn 
    2060                 2065                 2070             


Asn Glu  Val Glu Val Ile Thr  Lys Leu Gly Glu Arg  Lys Ile Leu 
    2075                 2080                 2085             


Arg Pro  Arg Trp Ile Asp Ala  Arg Val Tyr Ser Asp  His Gln Ala 
    2090                 2095                 2100             


Leu Lys  Ala Phe Lys Asp Phe  Ala Ser Gly Lys Arg  Ser Gln Ile 
    2105                 2110                 2115             


Gly Leu  Ile Glu Val Leu Gly  Lys Met Pro Glu His  Phe Met Gly 
    2120                 2125                 2130             


Lys Thr  Trp Glu Ala Leu Asp  Thr Met Tyr Val Val  Ala Thr Ala 
    2135                 2140                 2145             


Glu Lys  Gly Gly Arg Ala His  Arg Met Ala Leu Glu  Glu Leu Pro 
    2150                 2155                 2160             


Asp Ala  Leu Gln Thr Ile Ala  Leu Ile Ala Leu Leu  Ser Val Met 
    2165                 2170                 2175             


Thr Met  Gly Val Phe Phe Leu  Leu Met Gln Arg Lys  Gly Ile Gly 
    2180                 2185                 2190             


Lys Ile  Gly Leu Gly Gly Ala  Val Leu Gly Val Ala  Thr Phe Phe 
    2195                 2200                 2205             


Cys Trp  Met Ala Glu Val Pro  Gly Thr Lys Ile Ala  Gly Met Leu 
    2210                 2215                 2220             


Leu Leu  Ser Leu Leu Leu Met  Ile Val Leu Ile Pro  Glu Pro Glu 
    2225                 2230                 2235             


Lys Gln  Arg Ser Gln Thr Asp  Asn Gln Leu Ala Val  Phe Leu Ile 
    2240                 2245                 2250             


Cys Val  Met Thr Leu Val Ser  Ala Val Ala Ala Asn  Glu Met Gly 
    2255                 2260                 2265             


Trp Leu  Asp Lys Thr Lys Ser  Asp Ile Ser Ser Leu  Phe Gly Gln 
    2270                 2275                 2280             


Arg Ile  Glu Val Lys Glu Asn  Phe Ser Met Gly Glu  Phe Leu Leu 
    2285                 2290                 2295             


Asp Leu  Arg Pro Ala Thr Ala  Trp Ser Leu Tyr Ala  Val Thr Thr 
    2300                 2305                 2310             


Ala Val  Leu Thr Pro Leu Leu  Lys His Leu Ile Thr  Ser Asp Tyr 
    2315                 2320                 2325             


Ile Asn  Thr Ser Leu Thr Ser  Ile Asn Val Gln Ala  Ser Ala Leu 
    2330                 2335                 2340             


Phe Thr  Leu Ala Arg Gly Phe  Pro Phe Val Asp Val  Gly Val Ser 
    2345                 2350                 2355             


Ala Leu  Leu Leu Ala Ala Gly  Cys Trp Gly Gln Val  Thr Leu Thr 
    2360                 2365                 2370             


Val Thr  Val Thr Ala Ala Thr  Leu Leu Phe Cys His  Tyr Ala Tyr 
    2375                 2380                 2385             


Met Val  Pro Gly Trp Gln Ala  Glu Ala Met Arg Ser  Ala Gln Arg 
    2390                 2395                 2400             


Arg Thr  Ala Ala Gly Ile Met  Lys Asn Ala Val Val  Asp Gly Ile 
    2405                 2410                 2415             


Val Ala  Thr Asp Val Pro Glu  Leu Glu Arg Thr Thr  Pro Ile Met 
    2420                 2425                 2430             


Gln Lys  Lys Val Gly Gln Ile  Met Leu Ile Leu Val  Ser Leu Ala 
    2435                 2440                 2445             


Ala Val  Val Val Asn Pro Ser  Val Lys Thr Val Arg  Glu Ala Gly 
    2450                 2455                 2460             


Ile Leu  Ile Thr Ala Ala Ala  Val Thr Leu Trp Glu  Asn Gly Ala 
    2465                 2470                 2475             


Ser Ser  Val Trp Asn Ala Thr  Thr Ala Ile Gly Leu  Cys His Ile 
    2480                 2485                 2490             


Met Arg  Gly Gly Trp Leu Ser  Cys Leu Ser Ile Thr  Trp Thr Leu 
    2495                 2500                 2505             


Ile Lys  Asn Met Glu Lys Pro  Gly Leu Lys Arg Gly  Gly Ala Lys 
    2510                 2515                 2520             


Gly Arg  Thr Leu Gly Glu Val  Trp Lys Glu Arg Leu  Asn Gln Met 
    2525                 2530                 2535             


Thr Lys  Glu Glu Phe Thr Arg  Tyr Arg Lys Glu Ala  Ile Ile Glu 
    2540                 2545                 2550             


Val Asp  Arg Ser Ala Ala Lys  His Ala Arg Lys Glu  Gly Asn Val 
    2555                 2560                 2565             


Thr Gly  Gly His Pro Val Ser  Arg Gly Thr Ala Lys  Leu Arg Trp 
    2570                 2575                 2580             


Leu Val  Glu Arg Arg Phe Leu  Glu Pro Val Gly Lys  Val Ile Asp 
    2585                 2590                 2595             


Leu Gly  Cys Gly Arg Gly Gly  Trp Cys Tyr Tyr Met  Ala Thr Gln 
    2600                 2605                 2610             


Lys Arg  Val Gln Glu Val Arg  Gly Tyr Thr Lys Gly  Gly Pro Gly 
    2615                 2620                 2625             


His Glu  Glu Pro Gln Leu Val  Gln Ser Tyr Gly Trp  Asn Ile Val 
    2630                 2635                 2640             


Thr Met  Lys Ser Gly Val Asp  Val Phe Tyr Arg Pro  Ser Glu Cys 
    2645                 2650                 2655             


Cys Asp  Thr Leu Leu Cys Asp  Ile Gly Glu Ser Ser  Ser Ser Ala 
    2660                 2665                 2670             


Glu Val  Glu Glu His Arg Thr  Ile Arg Val Leu Glu  Met Val Glu 
    2675                 2680                 2685             


Asp Trp  Leu His Arg Gly Pro  Arg Glu Phe Cys Val  Lys Val Leu 
    2690                 2695                 2700             


Cys Pro  Tyr Met Pro Lys Val  Ile Glu Lys Met Glu  Leu Leu Gln 
    2705                 2710                 2715             


Arg Arg  Tyr Gly Gly Gly Leu  Val Arg Asn Pro Leu  Ser Arg Asn 
    2720                 2725                 2730             


Ser Thr  His Glu Met Tyr Trp  Val Ser Arg Ala Ser  Gly Asn Val 
    2735                 2740                 2745             


Val His  Ser Val Asn Met Thr  Ser Gln Val Leu Leu  Gly Arg Met 
    2750                 2755                 2760             


Glu Lys  Arg Thr Trp Lys Gly  Pro Gln Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Gly Lys Pro Leu  Leu Asn Ser 
    2780                 2785                 2790             


Asp Thr  Ser Lys Ile Lys Asn  Arg Ile Glu Arg Leu  Arg Arg Glu 
    2795                 2800                 2805             


Tyr Ser  Ser Thr Trp His His  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Asn  Tyr His Gly Ser Tyr  Asp Val Lys Pro Thr  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Val Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Thr  Ile Thr Asn Val Thr  Thr Met Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Phe  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Lys 
    2870                 2875                 2880             


Ala Pro  Glu Pro Pro Glu Gly  Val Lys Tyr Val Leu  Asn Glu Thr 
    2885                 2890                 2895             


Thr Asn  Trp Leu Trp Ala Phe  Leu Ala Arg Glu Lys  Arg Pro Arg 
    2900                 2905                 2910             


Met Cys  Ser Arg Glu Glu Phe  Ile Arg Lys Val Asn  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Met Phe Glu  Glu Gln Asn Gln Trp  Arg Ser Ala 
    2930                 2935                 2940             


Arg Glu  Ala Val Glu Asp Pro  Lys Phe Trp Glu Met  Val Asp Glu 
    2945                 2950                 2955             


Glu Arg  Glu Ala His Leu Arg  Gly Glu Cys His Thr  Cys Ile Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Pro Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Phe Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Leu Gly  Arg Lys Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Lys  Leu Gly Tyr Ile Leu  Arg Glu Val Gly Thr  Arg Pro Gly 
    3035                 3040                 3045             


Gly Lys  Ile Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Thr Arg  Ala Asp Leu Glu Asn  Glu Ala Lys Val Leu  Glu Leu Leu 
    3065                 3070                 3075             


Asp Gly  Glu His Arg Arg Leu  Ala Arg Ala Ile Ile  Glu Leu Thr 
    3080                 3085                 3090             


Tyr Arg  His Lys Val Val Lys  Val Met Arg Pro Ala  Ala Asp Gly 
    3095                 3100                 3105             


Arg Thr  Val Met Asp Val Ile  Ser Arg Glu Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Ala 
    3125                 3130                 3135             


Val Gln  Leu Val Arg Met Met  Glu Gly Glu Gly Val  Ile Gly Pro 
    3140                 3145                 3150             


Asp Asp  Val Glu Lys Leu Thr  Lys Gly Lys Gly Pro  Lys Val Arg 
    3155                 3160                 3165             


Thr Trp  Leu Phe Glu Asn Gly  Glu Glu Arg Leu Ser  Arg Met Ala 
    3170                 3175                 3180             


Val Ser  Gly Asp Asp Cys Val  Val Lys Pro Leu Asp  Asp Arg Phe 
    3185                 3190                 3195             


Ala Thr  Ser Leu His Phe Leu  Asn Ala Met Ser Lys  Val Arg Lys 
    3200                 3205                 3210             


Asp Ile  Gln Glu Trp Lys Pro  Ser Thr Gly Trp Tyr  Asp Trp Gln 
    3215                 3220                 3225             


Gln Val  Pro Phe Cys Ser Asn  His Phe Thr Glu Leu  Ile Met Lys 
    3230                 3235                 3240             


Asp Gly  Arg Thr Leu Val Val  Pro Cys Arg Gly Gln  Asp Glu Leu 
    3245                 3250                 3255             


Val Gly  Arg Ala Arg Ile Ser  Pro Gly Ala Gly Trp  Asn Val Arg 
    3260                 3265                 3270             


Asp Thr  Ala Cys Leu Ala Lys  Ser Tyr Ala Gln Met  Trp Leu Leu 
    3275                 3280                 3285             


Leu Tyr  Phe His Arg Arg Asp  Leu Arg Leu Met Ala  Asn Ala Ile 
    3290                 3295                 3300             


Cys Ser  Ala Val Pro Val Asn  Trp Val Pro Thr Gly  Arg Thr Thr 
    3305                 3310                 3315             


Trp Ser  Ile His Ala Gly Gly  Glu Trp Met Thr Thr  Glu Asp Met 
    3320                 3325                 3330             


Leu Glu  Val Trp Asn Arg Val  Trp Ile Glu Glu Asn  Glu Trp Met 
    3335                 3340                 3345             


Glu Asp  Lys Thr Pro Val Glu  Lys Trp Ser Asp Val  Pro Tyr Ser 
    3350                 3355                 3360             


Gly Lys  Arg Glu Asp Ile Trp  Cys Gly Ser Leu Ile  Gly Thr Arg 
    3365                 3370                 3375             


Ala Arg  Ala Thr Trp Ala Glu  Asn Ile Gln Val Ala  Ile Asn Gln 
    3380                 3385                 3390             


Val Arg  Ala Ile Ile Gly Asp  Glu Lys Tyr Val Asp  Tyr Met Ser 
    3395                 3400                 3405             


Ser Leu  Lys Arg Tyr Glu Asp  Thr Thr Leu Val Glu  Asp Thr Val 
    3410                 3415                 3420             


Leu 
    


<210>  19
<211>  10996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WN/DEN4 chimera with C107 Thr to Pro mutation


<220>
<221>  CDS
<222>  (97)..(10365)

<400>  19
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcg atg tct aag aaa cca gga        114
                                        Met Ser Lys Lys Pro Gly           
                                        1               5                 

ggg ccc ggc aag agc cgg gct gtc aat atg cta aaa cgc gga atg ccc        162
Gly Pro Gly Lys Ser Arg Ala Val Asn Met Leu Lys Arg Gly Met Pro           
            10                  15                  20                    

cgc gtg ttg tcc ttg att gga ctg aag agg gct atg ttg agc ctg atc        210
Arg Val Leu Ser Leu Ile Gly Leu Lys Arg Ala Met Leu Ser Leu Ile           
        25                  30                  35                        

gac ggc aag ggg cca ata cga ttt gtg ttg gct ctc ttg gcg ttc ttc        258
Asp Gly Lys Gly Pro Ile Arg Phe Val Leu Ala Leu Leu Ala Phe Phe           
    40                  45                  50                            

agg ttc aca gca att gct ccg acc cga gca gtg ctg gat cga tgg aga        306
Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala Val Leu Asp Arg Trp Arg           
55                  60                  65                  70            

ggt gtg aac aaa caa aca gcg atg aaa cac ctt ctg agt ttt aag aag        354
Gly Val Asn Lys Gln Thr Ala Met Lys His Leu Leu Ser Phe Lys Lys           
                75                  80                  85                

gaa cta ggg acc ttg acc agt gct atc aat cgg cgg agc tca aaa caa        402
Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn Arg Arg Ser Ser Lys Gln           
            90                  95                  100                   

aag aaa agg tca ccg ata aca ttg ctg tgc ttg att ccc acc gta atg        450
Lys Lys Arg Ser Pro Ile Thr Leu Leu Cys Leu Ile Pro Thr Val Met           
        105                 110                 115                       

gcg ttt cac ttg tca aca aga gat ggc gaa ccc ctc atg ata gtg gca        498
Ala Phe His Leu Ser Thr Arg Asp Gly Glu Pro Leu Met Ile Val Ala           
    120                 125                 130                           

aaa cat gaa agg ggg aga cct ctc ctg ttt aag aca aca gag ggg atc        546
Lys His Glu Arg Gly Arg Pro Leu Leu Phe Lys Thr Thr Glu Gly Ile           
135                 140                 145                 150           

aac aaa tgc act ctc att gcc atg gac ttg ggt gaa atg tgt gag gac        594
Asn Lys Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys Glu Asp           
                155                 160                 165               

act gtc acg tac aaa tgc ccc tta ctg gtc aat acc gaa cct gaa gac        642
Thr Val Thr Tyr Lys Cys Pro Leu Leu Val Asn Thr Glu Pro Glu Asp           
            170                 175                 180                   

att gat tgc tgg tgc aat ctc acg tct acc tgg gtc atg tat ggg aca        690
Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Met Tyr Gly Thr           
        185                 190                 195                       

tgc acc cag agc gga gaa cgg aga cga gag aag cgc tca gta gct tta        738
Cys Thr Gln Ser Gly Glu Arg Arg Arg Glu Lys Arg Ser Val Ala Leu           
    200                 205                 210                           

aca cca cat tca gga atg gga ttg gaa aca aga gct gag aca tgg atg        786
Thr Pro His Ser Gly Met Gly Leu Glu Thr Arg Ala Glu Thr Trp Met           
215                 220                 225                 230           

tca tcg gaa ggg gct tgg aag cat gct cag aga gta gag agc tgg ata        834
Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg Val Glu Ser Trp Ile           
                235                 240                 245               

ctc aga aac cca gga ttc gcg ctc ttg gca gga ttt atg gct tat atg        882
Leu Arg Asn Pro Gly Phe Ala Leu Leu Ala Gly Phe Met Ala Tyr Met           
            250                 255                 260                   

att ggg caa aca gga atc cag cga act gtc ttc ttt gtc cta atg atg        930
Ile Gly Gln Thr Gly Ile Gln Arg Thr Val Phe Phe Val Leu Met Met           
        265                 270                 275                       

ctg gtc gcc cca tcc tac gga atg cga tgc gta gga gta ggg aac aga        978
Leu Val Ala Pro Ser Tyr Gly Met Arg Cys Val Gly Val Gly Asn Arg           
    280                 285                 290                           

gac ttt gtg gaa gga gtc tca ggt gga gca tgg gtc gat ctg gtg cta       1026
Asp Phe Val Glu Gly Val Ser Gly Gly Ala Trp Val Asp Leu Val Leu           
295                 300                 305                 310           

gaa cat gga gga tgc gtc aca acc atg gcc cag gga aaa cca acc ttg       1074
Glu His Gly Gly Cys Val Thr Thr Met Ala Gln Gly Lys Pro Thr Leu           
                315                 320                 325               

gat ttt gaa ctg act aag aca aca gcc aag gaa gtg gct ctg tta aga       1122
Asp Phe Glu Leu Thr Lys Thr Thr Ala Lys Glu Val Ala Leu Leu Arg           
            330                 335                 340                   

acc tat tgc att gaa gcc tca ata tca aac ata acc acg gca aca aga       1170
Thr Tyr Cys Ile Glu Ala Ser Ile Ser Asn Ile Thr Thr Ala Thr Arg           
        345                 350                 355                       

tgt cca acg caa gga gag cct tat cta aaa gag gaa caa gac caa cag       1218
Cys Pro Thr Gln Gly Glu Pro Tyr Leu Lys Glu Glu Gln Asp Gln Gln           
    360                 365                 370                           

tac att tgc cgg aga gat gtg gta gac aga ggg tgg ggc aat ggc tgt       1266
Tyr Ile Cys Arg Arg Asp Val Val Asp Arg Gly Trp Gly Asn Gly Cys           
375                 380                 385                 390           

ggc ttg ttt gga aaa gga gga gtt gtg aca tgt gcg aag ttt tca tgt       1314
Gly Leu Phe Gly Lys Gly Gly Val Val Thr Cys Ala Lys Phe Ser Cys           
                395                 400                 405               

tcg ggg aag ata aca ggc aat ttg gtc caa att gag aac ctt gaa tac       1362
Ser Gly Lys Ile Thr Gly Asn Leu Val Gln Ile Glu Asn Leu Glu Tyr           
            410                 415                 420                   

aca gtg gtt gta aca gtc cac aat gga gac acc cat gca gta gga aat       1410
Thr Val Val Val Thr Val His Asn Gly Asp Thr His Ala Val Gly Asn           
        425                 430                 435                       

gac aca tcc aat cat gga gtt aca gcc acg ata act ccc agg tca cca       1458
Asp Thr Ser Asn His Gly Val Thr Ala Thr Ile Thr Pro Arg Ser Pro           
    440                 445                 450                           

tcg gtg gaa gtc aaa ttg ccg gac tat gga gaa cta aca ctc gat tgt       1506
Ser Val Glu Val Lys Leu Pro Asp Tyr Gly Glu Leu Thr Leu Asp Cys           
455                 460                 465                 470           

gaa ccc agg tct gga att gac ttt aat gag atg att ctg atg aaa atg       1554
Glu Pro Arg Ser Gly Ile Asp Phe Asn Glu Met Ile Leu Met Lys Met           
                475                 480                 485               

aaa aag aaa aca tgg ctt gtg cat aag caa tgg ttt ttg gat cta cct       1602
Lys Lys Lys Thr Trp Leu Val His Lys Gln Trp Phe Leu Asp Leu Pro           
            490                 495                 500                   

cta cca tgg aca gca gga gca gac aca tca gag gtt cac tgg aat tac       1650
Leu Pro Trp Thr Ala Gly Ala Asp Thr Ser Glu Val His Trp Asn Tyr           
        505                 510                 515                       

aaa gag aga atg gtg aca ttt aag gtt cct cat gcc aag aga cag gat       1698
Lys Glu Arg Met Val Thr Phe Lys Val Pro His Ala Lys Arg Gln Asp           
    520                 525                 530                           

gtg aca gtg ctg gga tct cag gaa gga gcc atg cat tct gcc ctc gct       1746
Val Thr Val Leu Gly Ser Gln Glu Gly Ala Met His Ser Ala Leu Ala           
535                 540                 545                 550           

gga gcc aca gaa gtg gac tcc ggt gat gga aat cac atg ttt gca gga       1794
Gly Ala Thr Glu Val Asp Ser Gly Asp Gly Asn His Met Phe Ala Gly           
                555                 560                 565               

cat ctc aag tgc aaa gtc cgt atg gag aaa ttg aga atc aag gga atg       1842
His Leu Lys Cys Lys Val Arg Met Glu Lys Leu Arg Ile Lys Gly Met           
            570                 575                 580                   

tca tac acg atg tgt tca gga aag ttc tca att gac aaa gag atg gca       1890
Ser Tyr Thr Met Cys Ser Gly Lys Phe Ser Ile Asp Lys Glu Met Ala           
        585                 590                 595                       

gaa aca cag cat ggg aca aca gtg gtg aaa gtc aag tat gaa ggt gct       1938
Glu Thr Gln His Gly Thr Thr Val Val Lys Val Lys Tyr Glu Gly Ala           
    600                 605                 610                           

gga gct ccg tgt aaa gtc ccc ata gag ata aga gat gtg aac aag gaa       1986
Gly Ala Pro Cys Lys Val Pro Ile Glu Ile Arg Asp Val Asn Lys Glu           
615                 620                 625                 630           

aaa gtg gtt ggg cgt atc atc tca tcc acc cct ttg gct gag aat acc       2034
Lys Val Val Gly Arg Ile Ile Ser Ser Thr Pro Leu Ala Glu Asn Thr           
                635                 640                 645               

aac agt gca acc aac ata gag tta gaa ccc ccc ttt ggg gac agc tac       2082
Asn Ser Ala Thr Asn Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser Tyr           
            650                 655                 660                   

ata gtg ata ggt gtt gga aac agt gca tta aca ctc cat tgg ttc agg       2130
Ile Val Ile Gly Val Gly Asn Ser Ala Leu Thr Leu His Trp Phe Arg           
        665                 670                 675                       

aaa ggg agt tcc att ggc aag atg ttt gag tcc aca tac aga ggt gca       2178
Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ser Thr Tyr Arg Gly Ala           
    680                 685                 690                           

aaa cga atg gcc att cta ggt gaa aca gct tgg gat ttt ggt tcc gtt       2226
Lys Arg Met Ala Ile Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser Val           
695                 700                 705                 710           

ggt gga ctg ttc aca tca ttg gga aag gct gtg cac cag gtt ttt gga       2274
Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala Val His Gln Val Phe Gly           
                715                 720                 725               

agt gtg tat aca acc atg ttt gga gga gtc tca tgg atg att aga atc       2322
Ser Val Tyr Thr Thr Met Phe Gly Gly Val Ser Trp Met Ile Arg Ile           
            730                 735                 740                   

cta att ggg ttc cta gtg ttg tgg att ggc acg aac tca agg aac act       2370
Leu Ile Gly Phe Leu Val Leu Trp Ile Gly Thr Asn Ser Arg Asn Thr           
        745                 750                 755                       

tca atg gct atg acg tgc ata gct gtt gga gga atc act ctg ttt ctg       2418
Ser Met Ala Met Thr Cys Ile Ala Val Gly Gly Ile Thr Leu Phe Leu           
    760                 765                 770                           

ggc ttc aca gtt caa gca gac tcc gga tgt gcc ata gac atc agc cgg       2466
Gly Phe Thr Val Gln Ala Asp Ser Gly Cys Ala Ile Asp Ile Ser Arg           
775                 780                 785                 790           

caa gag ctg aga tgt gga agt gga gtg ttc ata cac aat gat gtg gag       2514
Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile His Asn Asp Val Glu           
                795                 800                 805               

gct tgg atg gac cgg tac aag tat tac cct gaa acg cca caa ggc cta       2562
Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu Thr Pro Gln Gly Leu           
            810                 815                 820                   

gcc aag atc att cag aaa gct cat aag gaa gga gtg tgc ggt cta cga       2610
Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly Val Cys Gly Leu Arg           
        825                 830                 835                       

tca gtt tcc aga ctg gag cat caa atg tgg gaa gca gtg aag gac gag       2658
Ser Val Ser Arg Leu Glu His Gln Met Trp Glu Ala Val Lys Asp Glu           
    840                 845                 850                           

ctg aac act ctt ttg aag gag aat ggt gtg gac ctt agt gtc gtg gtt       2706
Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp Leu Ser Val Val Val           
855                 860                 865                 870           

gag aaa cag gag gga atg tac aag tca gca cct aaa cgc ctc acc gcc       2754
Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro Lys Arg Leu Thr Ala           
                875                 880                 885               

acc acg gaa aaa ttg gaa att ggc tgg aag gcc tgg gga aag agt att       2802
Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala Trp Gly Lys Ser Ile           
            890                 895                 900                   

tta ttt gca cca gaa ctc gcc aac aac acc ttt gtg gtt gat ggt ccg       2850
Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe Val Val Asp Gly Pro           
        905                 910                 915                       

gag acc aag gaa tgt ccg act cag aat cgc gct tgg aat agc tta gaa       2898
Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala Trp Asn Ser Leu Glu           
    920                 925                 930                           

gtg gag gat ttt gga ttt ggt ctc acc agc act cgg atg ttc ctg aag       2946
Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr Arg Met Phe Leu Lys           
935                 940                 945                 950           

gtc aga gag agc aac aca act gaa tgt gac tcg aag atc att gga acg       2994
Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser Lys Ile Ile Gly Thr           
                955                 960                 965               

gct gtc aag aac aac ttg gcg atc cac agt gac ctg tcc tat tgg att       3042
Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp Leu Ser Tyr Trp Ile           
            970                 975                 980                   

gaa agc agg ctc aat gat acg tgg aag ctt gaa agg gca gtt ctg ggt       3090
Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu Glu Arg Ala Val Leu Gly           
        985                 990                 995                       

gaa gtc  aaa tca tgt acg tgg  cct gag acg cat acc  ttg tgg ggc        3135
Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr His Thr  Leu Trp Gly            
    1000                 1005                 1010                        

gat gga  atc ctt gag agt gac  ttg ata ata cca gtc  aca ctg gcg        3180
Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile Pro Val  Thr Leu Ala            
    1015                 1020                 1025                        

gga cca  cga agc aat cac aat  cgg aga cct ggg tac  aag aca caa        3225
Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro Gly Tyr  Lys Thr Gln            
    1030                 1035                 1040                        

aac cag  ggc cca tgg gac gaa  ggc cgg gta gag att  gac ttc gat        3270
Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val Glu Ile  Asp Phe Asp            
    1045                 1050                 1055                        

tac tgc  cca gga act acg gtc  acc ctg agt gag agc  tgc gga cac        3315
Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser Glu Ser  Cys Gly His            
    1060                 1065                 1070                        

cgt gga  cct gcc act cgc acc  acc aca gag agc gga  aag ttg ata        3360
Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu Ser Gly  Lys Leu Ile            
    1075                 1080                 1085                        

aca gat  tgg tgc tgc agg agc  tgc acc tta cca cca  ctg cgc tac        3405
Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu Pro Pro  Leu Arg Tyr            
    1090                 1095                 1100                        

caa act  gac agc ggc tgt tgg  tat ggt atg gag atc  aga cca cag        3450
Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Gln            
    1105                 1110                 1115                        

aga cat  gat gaa aag acc ctc  gtg cag tca caa gtg  aat gct tat        3495
Arg His  Asp Glu Lys Thr Leu  Val Gln Ser Gln Val  Asn Ala Tyr            
    1120                 1125                 1130                        

aat gct  gat atg att gac cct  ttt cag ttg ggc ctt  ctg gtc gtg        3540
Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu Gly Leu  Leu Val Val            
    1135                 1140                 1145                        

ttc ttg  gcc acc cag gag gtc  ctt cgc aag agg tgg  aca gcc aag        3585
Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys Arg Trp  Thr Ala Lys            
    1150                 1155                 1160                        

atc agc  atg cca gct ata ctg  att gct ctg cta gtc  ctg gtg ttt        3630
Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu Leu Val  Leu Val Phe            
    1165                 1170                 1175                        

ggg ggc  att act tac act gat  gtg tta cgc tat gtc  atc ttg gtg        3675
Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg Tyr Val  Ile Leu Val            
    1180                 1185                 1190                        

ggg gca  gct ttc gca gaa tct  aat tcg gga gga gac  gtg gta cac        3720
Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly Gly Asp  Val Val His            
    1195                 1200                 1205                        

ttg gcg  ctc atg gcg acc ttc  aag ata caa cca gtg  ttt atg gtg        3765
Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln Pro Val  Phe Met Val            
    1210                 1215                 1220                        

gca tcg  ttt ctc aaa gcg aga  tgg acc aac cag gag  aac att ttg        3810
Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn Gln Glu  Asn Ile Leu            
    1225                 1230                 1235                        

ttg atg  ttg gcg gct gtt ttc  ttt caa atg gct tat  tac gat gcc        3855
Leu Met  Leu Ala Ala Val Phe  Phe Gln Met Ala Tyr  Tyr Asp Ala            
    1240                 1245                 1250                        

cgc caa  att ctg ctc tgg gag  atc cct gat gtg ttg  aat tca ctg        3900
Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp Val Leu  Asn Ser Leu            
    1255                 1260                 1265                        

gcg gta  gct tgg atg ata ctg  aga gcc ata aca ttc  aca acg aca        3945
Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile Thr Phe  Thr Thr Thr            
    1270                 1275                 1280                        

tca aac  gtg gtt gtt ccg ctg  cta gcc ctg cta aca  ccc ggg ctg        3990
Ser Asn  Val Val Val Pro Leu  Leu Ala Leu Leu Thr  Pro Gly Leu            
    1285                 1290                 1295                        

aga tgc  ttg aat ctg gat gtg  tac agg ata ctg ctg  ttg atg gtc        4035
Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile Leu Leu  Leu Met Val            
    1300                 1305                 1310                        

gga ata  ggc agc ttg atc agg  gag aag agg agt gca  gct gca aaa        4080
Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg Ser Ala  Ala Ala Lys            
    1315                 1320                 1325                        

aag aaa  gga gca agt ctg cta  tgc ttg gct cta gcc  tca aca gga        4125
Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala Leu Ala  Ser Thr Gly            
    1330                 1335                 1340                        

ctt ttc  aac ccc atg atc ctt  gct gct gga ctg att  gca tgt gat        4170
Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly Leu Ile  Ala Cys Asp            
    1345                 1350                 1355                        

ccc aac  cgt aaa cgc gga tgg  ccc gca act gaa gtg  atg aca gct        4215
Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr Glu Val  Met Thr Ala            
    1360                 1365                 1370                        

gtc ggc  cta atg ttt gcc atc  gtc gga ggg ctg gca  gag ctt gac        4260
Val Gly  Leu Met Phe Ala Ile  Val Gly Gly Leu Ala  Glu Leu Asp            
    1375                 1380                 1385                        

att gac  tcc atg gcc att cca  atg act atc gcg ggg  ctc atg ttt        4305
Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile Ala Gly  Leu Met Phe            
    1390                 1395                 1400                        

gct gct  ttc gtg att tct ggg  aaa tca aca gat atg  tgg att gag        4350
Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr Asp Met  Trp Ile Glu            
    1405                 1410                 1415                        

aga acg  gcg gac att tcc tgg  gaa agt gat gca gaa  att aca ggc        4395
Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp Ala Glu  Ile Thr Gly            
    1420                 1425                 1430                        

tcg agc  gaa aga gtt gat gtg  cgg ctt gat gat gat  gga aac ttc        4440
Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp Asp Asp  Gly Asn Phe            
    1435                 1440                 1445                        

cag ctc  atg aat gat cca gga  gca cct tgg aag ata  tgg atg ctc        4485
Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp Lys Ile  Trp Met Leu            
    1450                 1455                 1460                        

aga atg  gtc tgt ctc gcg att  agt gcg tac acc ccc  tgg gca atc        4530
Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr Thr Pro  Trp Ala Ile            
    1465                 1470                 1475                        

ttg ccc  tca gta gtt gga ttt  tgg ata act ctc caa  tac aca aag        4575
Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr Leu Gln  Tyr Thr Lys            
    1480                 1485                 1490                        

aga gga  ggc gtg ttg tgg gac  act ccc tca cca aag  gag tac aaa        4620
Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser Pro Lys  Glu Tyr Lys            
    1495                 1500                 1505                        

aag ggg  gac acg acc acc ggc  gtc tac agg atc atg  act cgt ggg        4665
Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg Ile Met  Thr Arg Gly            
    1510                 1515                 1520                        

ctg ctc  ggc agt tat caa gca  gga gcg ggc gtg atg  gtt gaa ggt        4710
Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly Val Met  Val Glu Gly            
    1525                 1530                 1535                        

gtt ttc  cac acc ctt tgg cat  aca aca aaa gga gcc  gct ttg atg        4755
Val Phe  His Thr Leu Trp His  Thr Thr Lys Gly Ala  Ala Leu Met            
    1540                 1545                 1550                        

agc gga  gag ggc cgc ctg gac  cca tac tgg ggc agt  gtc aag gag        4800
Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp Gly Ser  Val Lys Glu            
    1555                 1560                 1565                        

gat cga  ctt tgt tac gga gga  ccc tgg aaa ttg cag  cac aag tgg        4845
Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys Leu Gln  His Lys Trp            
    1570                 1575                 1580                        

aac ggg  cag gat gag gtg cag  atg att gtg gtg gaa  cct ggc agg        4890
Asn Gly  Gln Asp Glu Val Gln  Met Ile Val Val Glu  Pro Gly Arg            
    1585                 1590                 1595                        

aac gtt  aag aac gtc cag acg  aaa cca ggg gtg ttc  aaa aca cct        4935
Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly Val Phe  Lys Thr Pro            
    1600                 1605                 1610                        

gaa gga  gaa atc ggg gcc gtg  act ttg gac ttc ccc  act gga aca        4980
Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp Phe Pro  Thr Gly Thr            
    1615                 1620                 1625                        

tca ggc  tca cca ata gtg gac  aaa aac ggt gat gtg  att ggg ctt        5025
Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly Asp Val  Ile Gly Leu            
    1630                 1635                 1640                        

tat ggc  aat gga gtc ata atg  ccc aac ggc tca tac  ata agc gcg        5070
Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly Ser Tyr  Ile Ser Ala            
    1645                 1650                 1655                        

ata gtg  cag ggt gaa agg atg  gat gag cca atc cca  gcc gga ttc        5115
Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro Ile Pro  Ala Gly Phe            
    1660                 1665                 1670                        

gaa cct  gag atg ctg agg aaa  aaa cag atc act gta  ctg gat ctc        5160
Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile Thr Val  Leu Asp Leu            
    1675                 1680                 1685                        

cat ccc  ggc gcc ggt aaa aca  agg agg att ctg cca  cag atc atc        5205
His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile Leu Pro  Gln Ile Ile            
    1690                 1695                 1700                        

aaa gag  gcc ata aac aga aga  ctg aga aca gcc gtg  cta gca cca        5250
Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr Ala Val  Leu Ala Pro            
    1705                 1710                 1715                        

acc agg  gtt gtg gct gct gag  atg gct gaa gca ctg  aga gga ctg        5295
Thr Arg  Val Val Ala Ala Glu  Met Ala Glu Ala Leu  Arg Gly Leu            
    1720                 1725                 1730                        

ccc atc  cgg tac cag aca tcc  gca gtg ccc aga gaa  cat aat gga        5340
Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro Arg Glu  His Asn Gly            
    1735                 1740                 1745                        

aat gag  att gtt gat gtc atg  tgt cat gct acc ctc  acc cac agg        5385
Asn Glu  Ile Val Asp Val Met  Cys His Ala Thr Leu  Thr His Arg            
    1750                 1755                 1760                        

ctg atg  tct cct cac agg gtg  ccg aac tac aac ctg  ttc gtg atg        5430
Leu Met  Ser Pro His Arg Val  Pro Asn Tyr Asn Leu  Phe Val Met            
    1765                 1770                 1775                        

gat gag  gct cat ttc acc gac  cca gct agc att gca  gca aga ggt        5475
Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser Ile Ala  Ala Arg Gly            
    1780                 1785                 1790                        

tac att  tcc aca aag gtc gag  cta ggg gag gcg gcg  gca ata ttc        5520
Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu Ala Ala  Ala Ile Phe            
    1795                 1800                 1805                        

atg aca  gcc acc cca cca ggc  act tca gat cca ttc  cca gag tcc        5565
Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp Pro Phe  Pro Glu Ser            
    1810                 1815                 1820                        

aat tca  cca att tcc gac tta  cag act gag atc ccg  gat cga gct        5610
Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu Ile Pro  Asp Arg Ala            
    1825                 1830                 1835                        

tgg aac  tct gga tac gaa tgg  atc aca gaa tac acc  ggg aag acg        5655
Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu Tyr Thr  Gly Lys Thr            
    1840                 1845                 1850                        

gtt tgg  ttt gtg cct agt gtc  aag atg ggg aat gag  att gcc ctt        5700
Val Trp  Phe Val Pro Ser Val  Lys Met Gly Asn Glu  Ile Ala Leu            
    1855                 1860                 1865                        

tgc cta  caa cgt gct gga aag  aaa gta gtc caa ttg  aac aga aag        5745
Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val Gln Leu  Asn Arg Lys            
    1870                 1875                 1880                        

tcg tac  gag acg gag tac cca  aaa tgt aag aac gat  gat tgg gac        5790
Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys Asn Asp  Asp Trp Asp            
    1885                 1890                 1895                        

ttt gtt  atc aca aca gac ata  tct gaa atg ggg gct  aac ttc aag        5835
Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met Gly Ala  Asn Phe Lys            
    1900                 1905                 1910                        

gcg agc  agg gtg att gac agc  cgg aag agt gtg aaa  cca acc atc        5880
Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser Val Lys  Pro Thr Ile            
    1915                 1920                 1925                        

ata aca  gaa gga gaa ggg aga  gtg atc ctg gga gaa  cca tct gca        5925
Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu Gly Glu  Pro Ser Ala            
    1930                 1935                 1940                        

gtg aca  gca gct agt gcc gcc  cag aga cgt gga cgt  atc ggt aga        5970
Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg Gly Arg  Ile Gly Arg            
    1945                 1950                 1955                        

aat ccg  tcg caa gtt ggt gat  gag tac tgt tat ggg  ggg cac acg        6015
Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys Tyr Gly  Gly His Thr            
    1960                 1965                 1970                        

aat gaa  gac gac tcg aac ttc  gcc cat tgg act gag  gca cga atc        6060
Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp Thr Glu  Ala Arg Ile            
    1975                 1980                 1985                        

atg ctg  gac aac atc aac atg  cca aac gga ctg atc  gct caa ttc        6105
Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly Leu Ile  Ala Gln Phe            
    1990                 1995                 2000                        

tac caa  cca gag cgt gag aag  gta tat acc atg gat  ggg gaa tac        6150
Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr Met Asp  Gly Glu Tyr            
    2005                 2010                 2015                        

cgg ctc  aga gga gaa gag aga  aaa aac ttt ctg gaa  ctg ttg agg        6195
Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe Leu Glu  Leu Leu Arg            
    2020                 2025                 2030                        

act gca  gat ctg cca gtt tgg  ctg gct tac aag gtt  gca gcg gct        6240
Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr Lys Val  Ala Ala Ala            
    2035                 2040                 2045                        

gga gtg  tca tac cac gac cgg  agg tgg tgc ttt gat  ggt cct agg        6285
Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys Phe Asp  Gly Pro Arg            
    2050                 2055                 2060                        

aca aac  aca att tta gaa gac  aac aac gaa gtg gaa  gtc atc acg        6330
Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu Val Glu  Val Ile Thr            
    2065                 2070                 2075                        

aag ctt  ggt gaa agg aag att  ctg agg ccg cgc tgg  att gac gcc        6375
Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro Arg Trp  Ile Asp Ala            
    2080                 2085                 2090                        

agg gtg  tac tcg gat cac cag  gca cta aag gcg ttc  aag gac ttc        6420
Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys Ala Phe  Lys Asp Phe            
    2095                 2100                 2105                        

gcc tcg  gga aaa cgt tct cag  ata ggg ctc att gag  gtt ctg gga        6465
Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu Ile Glu  Val Leu Gly            
    2110                 2115                 2120                        

aag atg  cct gag cac ttc atg  ggg aag aca tgg gaa  gca ctt gac        6510
Lys Met  Pro Glu His Phe Met  Gly Lys Thr Trp Glu  Ala Leu Asp            
    2125                 2130                 2135                        

acc atg  tac gtt gtg gcc act  gca gag aaa gga gga  aga gct cac        6555
Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys Gly Gly  Arg Ala His            
    2140                 2145                 2150                        

aga atg  gcc ctg gag gaa ctg  cca gat gct ctt cag  aca att gcc        6600
Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala Leu Gln  Thr Ile Ala            
    2155                 2160                 2165                        

ttg att  gcc tta ttg agt gtg  atg acc atg gga gta  ttc ttc ctc        6645
Leu Ile  Ala Leu Leu Ser Val  Met Thr Met Gly Val  Phe Phe Leu            
    2170                 2175                 2180                        

ctc atg  cag cgg aag ggc att  gga aag ata ggt ttg  gga ggc gct        6690
Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile Gly Leu  Gly Gly Ala            
    2185                 2190                 2195                        

gtc ttg  gga gtc gcg acc ttt  ttc tgt tgg atg gct  gaa gtt cca        6735
Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp Met Ala  Glu Val Pro            
    2200                 2205                 2210                        

gga acg  aag atc gcc gga atg  ttg ctg ctc tcc ctt  ctc ttg atg        6780
Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu Ser Leu  Leu Leu Met            
    2215                 2220                 2225                        

att gtg  cta att cct gag cca  gag aag caa cgt tcg  cag aca gac        6825
Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln Arg Ser  Gln Thr Asp            
    2230                 2235                 2240                        

aac cag  cta gcc gtg ttc ctg  att tgt gtc atg acc  ctt gtg agc        6870
Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val Met Thr  Leu Val Ser            
    2245                 2250                 2255                        

gca gtg  gca gcc aac gag atg  ggt tgg cta gat aag  acc aag agt        6915
Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu Asp Lys  Thr Lys Ser            
    2260                 2265                 2270                        

gac ata  agc agt ttg ttt ggg  caa aga att gag gtc  aag gag aat        6960
Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile Glu Val  Lys Glu Asn            
    2275                 2280                 2285                        

ttc agc  atg gga gag ttt ctt  ttg gac ttg agg cct  gca aca gcc        7005
Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu Arg Pro  Ala Thr Ala            
    2290                 2295                 2300                        

tgg tca  ctg tac gct gtg aca  aca gcg gtc ctc act  cca ctg cta        7050
Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val Leu Thr  Pro Leu Leu            
    2305                 2310                 2315                        

aag cat  ttg atc acg tca gat  tac atc aac acc tca  ttg acc tca        7095
Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn Thr Ser  Leu Thr Ser            
    2320                 2325                 2330                        

ata aac  gtt cag gca agt gca  cta ttc aca ctc gcg  cga ggc ttc        7140
Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr Leu Ala  Arg Gly Phe            
    2335                 2340                 2345                        

ccc ttc  gtc gat gtt gga gtg  tcg gct ctc ctg cta  gca gcc gga        7185
Pro Phe  Val Asp Val Gly Val  Ser Ala Leu Leu Leu  Ala Ala Gly            
    2350                 2355                 2360                        

tgc tgg  gga caa gtc acc ctc  acc gtt acg gta aca  gcg gca aca        7230
Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr Val Thr  Ala Ala Thr            
    2365                 2370                 2375                        

ctc ctt  ttt tgc cac tat gcc  tac atg gtt ccc ggt  tgg caa gct        7275
Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val Pro Gly  Trp Gln Ala            
    2380                 2385                 2390                        

gag gca  atg cgc tca gcc cag  cgg cgg aca gcg gcc  gga atc atg        7320
Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr Ala Ala  Gly Ile Met            
    2395                 2400                 2405                        

aag aac  gct gta gtg gat ggc  atc gtg gcc acg gac  gtc cca gaa        7365
Lys Asn  Ala Val Val Asp Gly  Ile Val Ala Thr Asp  Val Pro Glu            
    2410                 2415                 2420                        

tta gag  cgc acc aca ccc atc  atg cag aag aaa gtt  gga cag atc        7410
Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys Lys Val  Gly Gln Ile            
    2425                 2430                 2435                        

atg ctg  atc ttg gtg tct cta  gct gca gta gta gtg  aac ccg tct        7455
Met Leu  Ile Leu Val Ser Leu  Ala Ala Val Val Val  Asn Pro Ser            
    2440                 2445                 2450                        

gtg aag  aca gta cga gaa gcc  gga att ttg atc acg  gcc gca gcg        7500
Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu Ile Thr  Ala Ala Ala            
    2455                 2460                 2465                        

gtg acg  ctt tgg gag aat gga  gca agc tct gtt tgg  aac gca aca        7545
Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser Val Trp  Asn Ala Thr            
    2470                 2475                 2480                        

act gcc  atc gga ctc tgc cac  atc atg cgt ggg ggt  tgg ttg tca        7590
Thr Ala  Ile Gly Leu Cys His  Ile Met Arg Gly Gly  Trp Leu Ser            
    2485                 2490                 2495                        

tgt cta  tcc ata aca tgg aca  ctc ata aag aac atg  gaa aaa cca        7635
Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys Asn Met  Glu Lys Pro            
    2500                 2505                 2510                        

gga cta  aaa aga ggt ggg gca  aaa gga cgc acc ttg  gga gag gtt        7680
Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg Thr Leu  Gly Glu Val            
    2515                 2520                 2525                        

tgg aaa  gaa aga ctc aac cag  atg aca aaa gaa gag  ttc act agg        7725
Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys Glu Glu  Phe Thr Arg            
    2530                 2535                 2540                        

tac cgc  aaa gag gcc atc atc  gaa gtc gat cgc tca  gcg gca aaa        7770
Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp Arg Ser  Ala Ala Lys            
    2545                 2550                 2555                        

cac gcc  agg aaa gaa ggc aat  gtc act gga ggg cat  cca gtc tct        7815
His Ala  Arg Lys Glu Gly Asn  Val Thr Gly Gly His  Pro Val Ser            
    2560                 2565                 2570                        

agg ggc  aca gca aaa ctg aga  tgg ctg gtc gaa cgg  agg ttt ctc        7860
Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val Glu Arg  Arg Phe Leu            
    2575                 2580                 2585                        

gaa ccg  gtc gga aaa gtg att  gac ctt gga tgt gga  aga ggc ggt        7905
Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly Cys Gly  Arg Gly Gly            
    2590                 2595                 2600                        

tgg tgt  tac tat atg gca acc  caa aaa aga gtc caa  gaa gtc aga        7950
Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg Val Gln  Glu Val Arg            
    2605                 2610                 2615                        

ggg tac  aca aag ggc ggt ccc  gga cat gaa gag ccc  caa cta gtg        7995
Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu Glu Pro  Gln Leu Val            
    2620                 2625                 2630                        

caa agt  tat gga tgg aac att  gtc acc atg aag agt  gga gtg gat        8040
Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met Lys Ser  Gly Val Asp            
    2635                 2640                 2645                        

gtg ttc  tac aga cct tct gag  tgt tgt gac acc ctc  ctt tgt gac        8085
Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp Thr Leu  Leu Cys Asp            
    2650                 2655                 2660                        

atc gga  gag tcc tcg tca agt  gct gag gtt gaa gag  cat agg acg        8130
Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val Glu Glu  His Arg Thr            
    2665                 2670                 2675                        

att cgg  gtc ctt gaa atg gtt  gag gac tgg ctg cac  cga ggg cca        8175
Ile Arg  Val Leu Glu Met Val  Glu Asp Trp Leu His  Arg Gly Pro            
    2680                 2685                 2690                        

agg gaa  ttt tgc gtg aag gtg  ctc tgc ccc tac atg  ccg aaa gtc        8220
Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro Tyr Met  Pro Lys Val            
    2695                 2700                 2705                        

ata gag  aag atg gag ctg ctc  caa cgc cgg tat ggg  ggg gga ctg        8265
Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg Tyr Gly  Gly Gly Leu            
    2710                 2715                 2720                        

gtc aga  aac cca ctc tca cgg  aat tcc acg cac gag  atg tat tgg        8310
Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr His Glu  Met Tyr Trp            
    2725                 2730                 2735                        

gtg agt  cga gct tca ggc aat  gtg gta cat tca gtg  aat atg acc        8355
Val Ser  Arg Ala Ser Gly Asn  Val Val His Ser Val  Asn Met Thr            
    2740                 2745                 2750                        

agc cag  gtg ctc cta gga aga  atg gaa aaa agg acc  tgg aag gga        8400
Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys Arg Thr  Trp Lys Gly            
    2755                 2760                 2765                        

ccc caa  tac gag gaa gat gta  aac ttg gga agt gga  acc agg gcg        8445
Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly Ser Gly  Thr Arg Ala            
    2770                 2775                 2780                        

gtg gga  aaa ccc ctg ctc aac  tca gac acc agt aaa  atc aag aac        8490
Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr Ser Lys  Ile Lys Asn            
    2785                 2790                 2795                        

agg att  gaa cga ctc agg cgt  gag tac agt tcg acg  tgg cac cac        8535
Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser Ser Thr  Trp His His            
    2800                 2805                 2810                        

gat gag  aac cac cca tat aga  acc tgg aac tat cac  ggc agt tat        8580
Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn Tyr His  Gly Ser Tyr            
    2815                 2820                 2825                        

gat gtg  aag ccc aca ggc tcc  gcc agt tcg ctg gtc  aat gga gtg        8625
Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser Leu Val  Asn Gly Val            
    2830                 2835                 2840                        

gtc agg  ctc ctc tca aaa cca  tgg gac acc atc acg  aat gtt acc        8670
Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr Ile Thr  Asn Val Thr            
    2845                 2850                 2855                        

acc atg  gcc atg act gac act  act ccc ttc ggg cag  cag cga gtg        8715
Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe Gly Gln  Gln Arg Val            
    2860                 2865                 2870                        

ttc aaa  gag aag gtg gac acg  aaa gct cct gaa ccg  cca gaa gga        8760
Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro Glu Pro  Pro Glu Gly            
    2875                 2880                 2885                        

gtg aag  tac gtg ctc aac gag  acc acc aac tgg ttg  tgg gcg ttt        8805
Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn Trp Leu  Trp Ala Phe            
    2890                 2895                 2900                        

ttg gcc  aga gaa aaa cgt ccc  aga atg tgc tct cga  gag gaa ttc        8850
Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys Ser Arg  Glu Glu Phe            
    2905                 2910                 2915                        

ata aga  aag gtc aac agc aat  gca gct ttg ggt gcc  atg ttt gaa        8895
Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu Gly Ala  Met Phe Glu            
    2920                 2925                 2930                        

gag cag  aat caa tgg agg agc  gcc aga gaa gca gtt  gaa gat cca        8940
Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu Ala Val  Glu Asp Pro            
    2935                 2940                 2945                        

aaa ttt  tgg gag atg gtg gat  gag gag cgc gag gca  cat ctg cgg        8985
Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg Glu Ala  His Leu Arg            
    2950                 2955                 2960                        

ggg gaa  tgt cac act tgc att  tac aac atg atg gga  aag aga gag        9030
Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met Met Gly  Lys Arg Glu            
    2965                 2970                 2975                        

aaa aaa  ccc gga gag ttc gga  aag gcc aag gga agc  aga gcc att        9075
Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys Gly Ser  Arg Ala Ile            
    2980                 2985                 2990                        

tgg ttc  atg tgg ctc gga gct  cgc ttt ctg gag ttc  gag gct ctg        9120
Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu Glu Phe  Glu Ala Leu            
    2995                 3000                 3005                        

ggt ttt  ctc aat gaa gac cac  tgg ctt gga aga aag  aac tca gga        9165
Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly Arg Lys  Asn Ser Gly            
    3010                 3015                 3020                        

gga ggt  gtc gag ggc ttg ggc  ctc caa aaa ctg ggt  tac atc ctg        9210
Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys Leu Gly  Tyr Ile Leu            
    3025                 3030                 3035                        

cgt gaa  gtt ggc acc cgg cct  ggg ggc aag atc tat  gct gat gac        9255
Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys Ile Tyr  Ala Asp Asp            
    3040                 3045                 3050                        

aca gct  ggc tgg gac acc cgc  atc acg aga gct gac  ttg gaa aat        9300
Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg Ala Asp  Leu Glu Asn            
    3055                 3060                 3065                        

gaa gct  aag gtg ctt gag ctg  ctt gat ggg gaa cat  cgg cgt ctt        9345
Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly Glu His  Arg Arg Leu            
    3070                 3075                 3080                        

gcc agg  gcc atc att gag ctc  acc tat cgt cac aaa  gtt gtg aaa        9390
Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg His Lys  Val Val Lys            
    3085                 3090                 3095                        

gtg atg  cgc ccg gct gct gat  gga aga acc gtc atg  gat gtt atc        9435
Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr Val Met  Asp Val Ile            
    3100                 3105                 3110                        

tcc aga  gaa gat cag agg ggg  agt gga caa gtt gtc  acc tac gcc        9480
Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln Val Val  Thr Tyr Ala            
    3115                 3120                 3125                        

cta aac  act ttc acc aac ctg  gcc gtc cag ctg gtg  agg atg atg        9525
Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln Leu Val  Arg Met Met            
    3130                 3135                 3140                        

gaa ggg  gaa gga gtg att ggc  cca gat gat gtg gag  aaa ctc aca        9570
Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp Val Glu  Lys Leu Thr            
    3145                 3150                 3155                        

aaa ggg  aaa gga ccc aaa gtc  agg acc tgg ctg ttt  gag aat ggg        9615
Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp Leu Phe  Glu Asn Gly            
    3160                 3165                 3170                        

gaa gaa  aga ctc agc cgc atg  gct gtc agt gga gat  gac tgt gtg        9660
Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser Gly Asp  Asp Cys Val            
    3175                 3180                 3185                        

gta aag  ccc ctg gac gat cgc  ttt gcc acc tcg ctc  cac ttc ctc        9705
Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr Ser Leu  His Phe Leu            
    3190                 3195                 3200                        

aat gct  atg tca aag gtt cgc  aaa gac atc caa gag  tgg aaa ccg        9750
Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile Gln Glu  Trp Lys Pro            
    3205                 3210                 3215                        

tca act  gga tgg tat gat tgg  cag cag gtt cca ttt  tgc tca aac        9795
Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val Pro Phe  Cys Ser Asn            
    3220                 3225                 3230                        

cat ttc  act gaa ttg atc atg  aaa gat gga aga aca  ctg gtg gtt        9840
His Phe  Thr Glu Leu Ile Met  Lys Asp Gly Arg Thr  Leu Val Val            
    3235                 3240                 3245                        

cca tgc  cga gga cag gat gaa  ttg gta ggc aga gct  cgc ata tct        9885
Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly Arg Ala  Arg Ile Ser            
    3250                 3255                 3260                        

cca ggg  gcc gga tgg aac gtc  cgc gac act gct tgt  ctg gct aag        9930
Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr Ala Cys  Leu Ala Lys            
    3265                 3270                 3275                        

tct tat  gcc cag atg tgg ctg  ctt ctg tac ttc cac  aga aga gac        9975
Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr Phe His  Arg Arg Asp            
    3280                 3285                 3290                        

ctg cgg  ctc atg gcc aac gcc  att tgc tcc gct gtc  cct gtg aat       10020
Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser Ala Val  Pro Val Asn            
    3295                 3300                 3305                        

tgg gtc  cct acc gga aga acc  acg tgg tcc atc cat  gca gga gga       10065
Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser Ile His  Ala Gly Gly            
    3310                 3315                 3320                        

gag tgg  atg aca aca gag gac  atg ttg gag gtc tgg  aac cgt gtt       10110
Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu Val Trp  Asn Arg Val            
    3325                 3330                 3335                        

tgg ata  gag gag aat gaa tgg  atg gaa gac aaa acc  cca gtg gag       10155
Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp Lys Thr  Pro Val Glu            
    3340                 3345                 3350                        

aaa tgg  agt gac gtc cca tat  tca gga aaa cga gag  gac atc tgg       10200
Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys Arg Glu  Asp Ile Trp            
    3355                 3360                 3365                        

tgt ggc  agc ctg att ggc aca  aga gcc cga gcc acg  tgg gca gaa       10245
Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg Ala Thr  Trp Ala Glu            
    3370                 3375                 3380                        

aac atc  cag gtg gct atc aac  caa gtc aga gca atc  atc gga gat       10290
Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg Ala Ile  Ile Gly Asp            
    3385                 3390                 3395                        

gag aag  tat gtg gat tac atg  agt tca cta aag aga  tat gaa gac       10335
Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu Lys Arg  Tyr Glu Asp            
    3400                 3405                 3410                        

aca act  ttg gtt gag gac aca  gta ctg tag atatttaatc aattgtaaat      10385
Thr Thr  Leu Val Glu Asp Thr  Val Leu                                     
    3415                 3420                                             

agacaatata agtatgcata aaagtgtagt tttatagtag tatttagtgg tgttagtgta    10445

aatagttaag aaaattttga ggagaaagtc aggccgggaa gttcccgcca ccggaagttg    10505

agtagacggt gctgcctgcg actcaacccc aggaggactg ggtgaacaaa gccgcgaagt    10565

gatccatgta agccctcaga accgtctcgg aaggaggacc ccacatgttg taacttcaaa    10625

gcccaatgtc agaccacgct acggcgtgct actctgcgga gagtgcagtc tgcgatagtg    10685

ccccaggagg actgggttaa caaaggcaaa ccaacgcccc acgcggccct agccccggta    10745

atggtgttaa ccagggcgaa aggactagag gttagaggag accccgcggt ttaaagtgca    10805

cggcccagcc tggctgaagc tgtaggtcag gggaaggact agaggttagt ggagaccccg    10865

tgccacaaaa caccacaaca aaacagcata ttgacacctg ggatagacta ggagatcttc    10925

tgctctgcac aaccagccac acggcacagt gcgccgacaa tggtggctgg tggtgcgaga    10985

acacaggatc t                                                         10996


<210>  20
<211>  3422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Ser Pro Ile Thr Leu Leu Cys 
            100                 105                 110         


Leu Ile Pro Thr Val Met Ala Phe His Leu Ser Thr Arg Asp Gly Glu 
        115                 120                 125             


Pro Leu Met Ile Val Ala Lys His Glu Arg Gly Arg Pro Leu Leu Phe 
    130                 135                 140                 


Lys Thr Thr Glu Gly Ile Asn Lys Cys Thr Leu Ile Ala Met Asp Leu 
145                 150                 155                 160 


Gly Glu Met Cys Glu Asp Thr Val Thr Tyr Lys Cys Pro Leu Leu Val 
                165                 170                 175     


Asn Thr Glu Pro Glu Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr 
            180                 185                 190         


Trp Val Met Tyr Gly Thr Cys Thr Gln Ser Gly Glu Arg Arg Arg Glu 
        195                 200                 205             


Lys Arg Ser Val Ala Leu Thr Pro His Ser Gly Met Gly Leu Glu Thr 
    210                 215                 220                 


Arg Ala Glu Thr Trp Met Ser Ser Glu Gly Ala Trp Lys His Ala Gln 
225                 230                 235                 240 


Arg Val Glu Ser Trp Ile Leu Arg Asn Pro Gly Phe Ala Leu Leu Ala 
                245                 250                 255     


Gly Phe Met Ala Tyr Met Ile Gly Gln Thr Gly Ile Gln Arg Thr Val 
            260                 265                 270         


Phe Phe Val Leu Met Met Leu Val Ala Pro Ser Tyr Gly Met Arg Cys 
        275                 280                 285             


Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ala 
    290                 295                 300                 


Trp Val Asp Leu Val Leu Glu His Gly Gly Cys Val Thr Thr Met Ala 
305                 310                 315                 320 


Gln Gly Lys Pro Thr Leu Asp Phe Glu Leu Thr Lys Thr Thr Ala Lys 
                325                 330                 335     


Glu Val Ala Leu Leu Arg Thr Tyr Cys Ile Glu Ala Ser Ile Ser Asn 
            340                 345                 350         


Ile Thr Thr Ala Thr Arg Cys Pro Thr Gln Gly Glu Pro Tyr Leu Lys 
        355                 360                 365             


Glu Glu Gln Asp Gln Gln Tyr Ile Cys Arg Arg Asp Val Val Asp Arg 
    370                 375                 380                 


Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly Val Val Thr 
385                 390                 395                 400 


Cys Ala Lys Phe Ser Cys Ser Gly Lys Ile Thr Gly Asn Leu Val Gln 
                405                 410                 415     


Ile Glu Asn Leu Glu Tyr Thr Val Val Val Thr Val His Asn Gly Asp 
            420                 425                 430         


Thr His Ala Val Gly Asn Asp Thr Ser Asn His Gly Val Thr Ala Thr 
        435                 440                 445             


Ile Thr Pro Arg Ser Pro Ser Val Glu Val Lys Leu Pro Asp Tyr Gly 
    450                 455                 460                 


Glu Leu Thr Leu Asp Cys Glu Pro Arg Ser Gly Ile Asp Phe Asn Glu 
465                 470                 475                 480 


Met Ile Leu Met Lys Met Lys Lys Lys Thr Trp Leu Val His Lys Gln 
                485                 490                 495     


Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ala Gly Ala Asp Thr Ser 
            500                 505                 510         


Glu Val His Trp Asn Tyr Lys Glu Arg Met Val Thr Phe Lys Val Pro 
        515                 520                 525             


His Ala Lys Arg Gln Asp Val Thr Val Leu Gly Ser Gln Glu Gly Ala 
    530                 535                 540                 


Met His Ser Ala Leu Ala Gly Ala Thr Glu Val Asp Ser Gly Asp Gly 
545                 550                 555                 560 


Asn His Met Phe Ala Gly His Leu Lys Cys Lys Val Arg Met Glu Lys 
                565                 570                 575     


Leu Arg Ile Lys Gly Met Ser Tyr Thr Met Cys Ser Gly Lys Phe Ser 
            580                 585                 590         


Ile Asp Lys Glu Met Ala Glu Thr Gln His Gly Thr Thr Val Val Lys 
        595                 600                 605             


Val Lys Tyr Glu Gly Ala Gly Ala Pro Cys Lys Val Pro Ile Glu Ile 
    610                 615                 620                 


Arg Asp Val Asn Lys Glu Lys Val Val Gly Arg Ile Ile Ser Ser Thr 
625                 630                 635                 640 


Pro Leu Ala Glu Asn Thr Asn Ser Ala Thr Asn Ile Glu Leu Glu Pro 
                645                 650                 655     


Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asn Ser Ala Leu 
            660                 665                 670         


Thr Leu His Trp Phe Arg Lys Gly Ser Ser Ile Gly Lys Met Phe Glu 
        675                 680                 685             


Ser Thr Tyr Arg Gly Ala Lys Arg Met Ala Ile Leu Gly Glu Thr Ala 
    690                 695                 700                 


Trp Asp Phe Gly Ser Val Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala 
705                 710                 715                 720 


Val His Gln Val Phe Gly Ser Val Tyr Thr Thr Met Phe Gly Gly Val 
                725                 730                 735     


Ser Trp Met Ile Arg Ile Leu Ile Gly Phe Leu Val Leu Trp Ile Gly 
            740                 745                 750         


Thr Asn Ser Arg Asn Thr Ser Met Ala Met Thr Cys Ile Ala Val Gly 
        755                 760                 765             


Gly Ile Thr Leu Phe Leu Gly Phe Thr Val Gln Ala Asp Ser Gly Cys 
    770                 775                 780                 


Ala Ile Asp Ile Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe 
785                 790                 795                 800 


Ile His Asn Asp Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro 
                805                 810                 815     


Glu Thr Pro Gln Gly Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu 
            820                 825                 830         


Gly Val Cys Gly Leu Arg Ser Val Ser Arg Leu Glu His Gln Met Trp 
        835                 840                 845             


Glu Ala Val Lys Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val 
    850                 855                 860                 


Asp Leu Ser Val Val Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala 
865                 870                 875                 880 


Pro Lys Arg Leu Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys 
                885                 890                 895     


Ala Trp Gly Lys Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr 
            900                 905                 910         


Phe Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg 
        915                 920                 925             


Ala Trp Asn Ser Leu Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser 
    930                 935                 940                 


Thr Arg Met Phe Leu Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp 
945                 950                 955                 960 


Ser Lys Ile Ile Gly Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser 
                965                 970                 975     


Asp Leu Ser Tyr Trp Ile Glu Ser Arg Leu Asn Asp Thr Trp Lys Leu 
            980                 985                 990         


Glu Arg Ala Val Leu Gly Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr 
        995                 1000                 1005             


His Thr  Leu Trp Gly Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile 
    1010                 1015                 1020             


Pro Val  Thr Leu Ala Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro 
    1025                 1030                 1035             


Gly Tyr  Lys Thr Gln Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val 
    1040                 1045                 1050             


Glu Ile  Asp Phe Asp Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser 
    1055                 1060                 1065             


Glu Ser  Cys Gly His Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu 
    1070                 1075                 1080             


Ser Gly  Lys Leu Ile Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu 
    1085                 1090                 1095             


Pro Pro  Leu Arg Tyr Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met 
    1100                 1105                 1110             


Glu Ile  Arg Pro Gln Arg His  Asp Glu Lys Thr Leu  Val Gln Ser 
    1115                 1120                 1125             


Gln Val  Asn Ala Tyr Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu 
    1130                 1135                 1140             


Gly Leu  Leu Val Val Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys 
    1145                 1150                 1155             


Arg Trp  Thr Ala Lys Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu 
    1160                 1165                 1170             


Leu Val  Leu Val Phe Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg 
    1175                 1180                 1185             


Tyr Val  Ile Leu Val Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly 
    1190                 1195                 1200             


Gly Asp  Val Val His Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln 
    1205                 1210                 1215             


Pro Val  Phe Met Val Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn 
    1220                 1225                 1230             


Gln Glu  Asn Ile Leu Leu Met  Leu Ala Ala Val Phe  Phe Gln Met 
    1235                 1240                 1245             


Ala Tyr  Tyr Asp Ala Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp 
    1250                 1255                 1260             


Val Leu  Asn Ser Leu Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile 
    1265                 1270                 1275             


Thr Phe  Thr Thr Thr Ser Asn  Val Val Val Pro Leu  Leu Ala Leu 
    1280                 1285                 1290             


Leu Thr  Pro Gly Leu Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile 
    1295                 1300                 1305             


Leu Leu  Leu Met Val Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg 
    1310                 1315                 1320             


Ser Ala  Ala Ala Lys Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala 
    1325                 1330                 1335             


Leu Ala  Ser Thr Gly Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly 
    1340                 1345                 1350             


Leu Ile  Ala Cys Asp Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr 
    1355                 1360                 1365             


Glu Val  Met Thr Ala Val Gly  Leu Met Phe Ala Ile  Val Gly Gly 
    1370                 1375                 1380             


Leu Ala  Glu Leu Asp Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile 
    1385                 1390                 1395             


Ala Gly  Leu Met Phe Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr 
    1400                 1405                 1410             


Asp Met  Trp Ile Glu Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp 
    1415                 1420                 1425             


Ala Glu  Ile Thr Gly Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp 
    1430                 1435                 1440             


Asp Asp  Gly Asn Phe Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp 
    1445                 1450                 1455             


Lys Ile  Trp Met Leu Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr 
    1460                 1465                 1470             


Thr Pro  Trp Ala Ile Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr 
    1475                 1480                 1485             


Leu Gln  Tyr Thr Lys Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser 
    1490                 1495                 1500             


Pro Lys  Glu Tyr Lys Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg 
    1505                 1510                 1515             


Ile Met  Thr Arg Gly Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly 
    1520                 1525                 1530             


Val Met  Val Glu Gly Val Phe  His Thr Leu Trp His  Thr Thr Lys 
    1535                 1540                 1545             


Gly Ala  Ala Leu Met Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp 
    1550                 1555                 1560             


Gly Ser  Val Lys Glu Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys 
    1565                 1570                 1575             


Leu Gln  His Lys Trp Asn Gly  Gln Asp Glu Val Gln  Met Ile Val 
    1580                 1585                 1590             


Val Glu  Pro Gly Arg Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly 
    1595                 1600                 1605             


Val Phe  Lys Thr Pro Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp 
    1610                 1615                 1620             


Phe Pro  Thr Gly Thr Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly 
    1625                 1630                 1635             


Asp Val  Ile Gly Leu Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly 
    1640                 1645                 1650             


Ser Tyr  Ile Ser Ala Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro 
    1655                 1660                 1665             


Ile Pro  Ala Gly Phe Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile 
    1670                 1675                 1680             


Thr Val  Leu Asp Leu His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile 
    1685                 1690                 1695             


Leu Pro  Gln Ile Ile Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr 
    1700                 1705                 1710             


Ala Val  Leu Ala Pro Thr Arg  Val Val Ala Ala Glu  Met Ala Glu 
    1715                 1720                 1725             


Ala Leu  Arg Gly Leu Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro 
    1730                 1735                 1740             


Arg Glu  His Asn Gly Asn Glu  Ile Val Asp Val Met  Cys His Ala 
    1745                 1750                 1755             


Thr Leu  Thr His Arg Leu Met  Ser Pro His Arg Val  Pro Asn Tyr 
    1760                 1765                 1770             


Asn Leu  Phe Val Met Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser 
    1775                 1780                 1785             


Ile Ala  Ala Arg Gly Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu 
    1790                 1795                 1800             


Ala Ala  Ala Ile Phe Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp 
    1805                 1810                 1815             


Pro Phe  Pro Glu Ser Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu 
    1820                 1825                 1830             


Ile Pro  Asp Arg Ala Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu 
    1835                 1840                 1845             


Tyr Thr  Gly Lys Thr Val Trp  Phe Val Pro Ser Val  Lys Met Gly 
    1850                 1855                 1860             


Asn Glu  Ile Ala Leu Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val 
    1865                 1870                 1875             


Gln Leu  Asn Arg Lys Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys 
    1880                 1885                 1890             


Asn Asp  Asp Trp Asp Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met 
    1895                 1900                 1905             


Gly Ala  Asn Phe Lys Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser 
    1910                 1915                 1920             


Val Lys  Pro Thr Ile Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu 
    1925                 1930                 1935             


Gly Glu  Pro Ser Ala Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg 
    1940                 1945                 1950             


Gly Arg  Ile Gly Arg Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys 
    1955                 1960                 1965             


Tyr Gly  Gly His Thr Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp 
    1970                 1975                 1980             


Thr Glu  Ala Arg Ile Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly 
    1985                 1990                 1995             


Leu Ile  Ala Gln Phe Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr 
    2000                 2005                 2010             


Met Asp  Gly Glu Tyr Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe 
    2015                 2020                 2025             


Leu Glu  Leu Leu Arg Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr 
    2030                 2035                 2040             


Lys Val  Ala Ala Ala Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys 
    2045                 2050                 2055             


Phe Asp  Gly Pro Arg Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu 
    2060                 2065                 2070             


Val Glu  Val Ile Thr Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro 
    2075                 2080                 2085             


Arg Trp  Ile Asp Ala Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys 
    2090                 2095                 2100             


Ala Phe  Lys Asp Phe Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu 
    2105                 2110                 2115             


Ile Glu  Val Leu Gly Lys Met  Pro Glu His Phe Met  Gly Lys Thr 
    2120                 2125                 2130             


Trp Glu  Ala Leu Asp Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys 
    2135                 2140                 2145             


Gly Gly  Arg Ala His Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala 
    2150                 2155                 2160             


Leu Gln  Thr Ile Ala Leu Ile  Ala Leu Leu Ser Val  Met Thr Met 
    2165                 2170                 2175             


Gly Val  Phe Phe Leu Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile 
    2180                 2185                 2190             


Gly Leu  Gly Gly Ala Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp 
    2195                 2200                 2205             


Met Ala  Glu Val Pro Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu 
    2210                 2215                 2220             


Ser Leu  Leu Leu Met Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln 
    2225                 2230                 2235             


Arg Ser  Gln Thr Asp Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val 
    2240                 2245                 2250             


Met Thr  Leu Val Ser Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu 
    2255                 2260                 2265             


Asp Lys  Thr Lys Ser Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile 
    2270                 2275                 2280             


Glu Val  Lys Glu Asn Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu 
    2285                 2290                 2295             


Arg Pro  Ala Thr Ala Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val 
    2300                 2305                 2310             


Leu Thr  Pro Leu Leu Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn 
    2315                 2320                 2325             


Thr Ser  Leu Thr Ser Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr 
    2330                 2335                 2340             


Leu Ala  Arg Gly Phe Pro Phe  Val Asp Val Gly Val  Ser Ala Leu 
    2345                 2350                 2355             


Leu Leu  Ala Ala Gly Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr 
    2360                 2365                 2370             


Val Thr  Ala Ala Thr Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val 
    2375                 2380                 2385             


Pro Gly  Trp Gln Ala Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr 
    2390                 2395                 2400             


Ala Ala  Gly Ile Met Lys Asn  Ala Val Val Asp Gly  Ile Val Ala 
    2405                 2410                 2415             


Thr Asp  Val Pro Glu Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys 
    2420                 2425                 2430             


Lys Val  Gly Gln Ile Met Leu  Ile Leu Val Ser Leu  Ala Ala Val 
    2435                 2440                 2445             


Val Val  Asn Pro Ser Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu 
    2450                 2455                 2460             


Ile Thr  Ala Ala Ala Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser 
    2465                 2470                 2475             


Val Trp  Asn Ala Thr Thr Ala  Ile Gly Leu Cys His  Ile Met Arg 
    2480                 2485                 2490             


Gly Gly  Trp Leu Ser Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys 
    2495                 2500                 2505             


Asn Met  Glu Lys Pro Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg 
    2510                 2515                 2520             


Thr Leu  Gly Glu Val Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys 
    2525                 2530                 2535             


Glu Glu  Phe Thr Arg Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp 
    2540                 2545                 2550             


Arg Ser  Ala Ala Lys His Ala  Arg Lys Glu Gly Asn  Val Thr Gly 
    2555                 2560                 2565             


Gly His  Pro Val Ser Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val 
    2570                 2575                 2580             


Glu Arg  Arg Phe Leu Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly 
    2585                 2590                 2595             


Cys Gly  Arg Gly Gly Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg 
    2600                 2605                 2610             


Val Gln  Glu Val Arg Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu 
    2615                 2620                 2625             


Glu Pro  Gln Leu Val Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met 
    2630                 2635                 2640             


Lys Ser  Gly Val Asp Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp 
    2645                 2650                 2655             


Thr Leu  Leu Cys Asp Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val 
    2660                 2665                 2670             


Glu Glu  His Arg Thr Ile Arg  Val Leu Glu Met Val  Glu Asp Trp 
    2675                 2680                 2685             


Leu His  Arg Gly Pro Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro 
    2690                 2695                 2700             


Tyr Met  Pro Lys Val Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg 
    2705                 2710                 2715             


Tyr Gly  Gly Gly Leu Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr 
    2720                 2725                 2730             


His Glu  Met Tyr Trp Val Ser  Arg Ala Ser Gly Asn  Val Val His 
    2735                 2740                 2745             


Ser Val  Asn Met Thr Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys 
    2750                 2755                 2760             


Arg Thr  Trp Lys Gly Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly 
    2765                 2770                 2775             


Ser Gly  Thr Arg Ala Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr 
    2780                 2785                 2790             


Ser Lys  Ile Lys Asn Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser 
    2795                 2800                 2805             


Ser Thr  Trp His His Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn 
    2810                 2815                 2820             


Tyr His  Gly Ser Tyr Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser 
    2825                 2830                 2835             


Leu Val  Asn Gly Val Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr 
    2840                 2845                 2850             


Ile Thr  Asn Val Thr Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2855                 2860                 2865             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro 
    2870                 2875                 2880             


Glu Pro  Pro Glu Gly Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn 
    2885                 2890                 2895             


Trp Leu  Trp Ala Phe Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys 
    2900                 2905                 2910             


Ser Arg  Glu Glu Phe Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu 
    2915                 2920                 2925             


Gly Ala  Met Phe Glu Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu 
    2930                 2935                 2940             


Ala Val  Glu Asp Pro Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg 
    2945                 2950                 2955             


Glu Ala  His Leu Arg Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met 
    2960                 2965                 2970             


Met Gly  Lys Arg Glu Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys 
    2975                 2980                 2985             


Gly Ser  Arg Ala Ile Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu 
    2990                 2995                 3000             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly 
    3005                 3010                 3015             


Arg Lys  Asn Ser Gly Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys 
    3020                 3025                 3030             


Leu Gly  Tyr Ile Leu Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys 
    3035                 3040                 3045             


Ile Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg 
    3050                 3055                 3060             


Ala Asp  Leu Glu Asn Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly 
    3065                 3070                 3075             


Glu His  Arg Arg Leu Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg 
    3080                 3085                 3090             


His Lys  Val Val Lys Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr 
    3095                 3100                 3105             


Val Met  Asp Val Ile Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln 
    3110                 3115                 3120             


Val Val  Thr Tyr Ala Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln 
    3125                 3130                 3135             


Leu Val  Arg Met Met Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp 
    3140                 3145                 3150             


Val Glu  Lys Leu Thr Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp 
    3155                 3160                 3165             


Leu Phe  Glu Asn Gly Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr 
    3185                 3190                 3195             


Ser Leu  His Phe Leu Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser Asn His Phe  Thr Glu Leu Ile Met  Lys Asp Gly 
    3230                 3235                 3240             


Arg Thr  Leu Val Val Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly 
    3245                 3250                 3255             


Arg Ala  Arg Ile Ser Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ala Val  Pro Val Asn Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Ala Gly Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Glu Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Ile Trp Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg 
    3365                 3370                 3375             


Ala Thr  Trp Ala Glu Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg 
    3380                 3385                 3390             


Ala Ile  Ile Gly Asp Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu 
    3395                 3400                 3405             


Lys Arg  Tyr Glu Asp Thr Thr  Leu Val Glu Asp Thr  Val Leu 
    3410                 3415                 3420         


<210>  21
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C protein signal sequence of WN/DEN1 chimera with Type II 
       junction

<400>  21

Gly Gly Lys Thr Gly Ile Thr Met Leu Leu Met Leu Leu Pro Thr Ala 
1               5                   10                  15      


Leu Ala 
        


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C protein signal sequence of WN/DEN2 chimera with Type II 
       junction

<400>  22

Gly Gly Lys Thr Gly Ile Gly Met Ile Ile Met Leu Ile Pro Thr Val 
1               5                   10                  15      


Met Ala 
        


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C protein signal sequence of WN/DEN4 chimera with Type II 
       junction

<400>  23

Gly Gly Lys Thr Gly Ile Ile Thr Leu Leu Cys Leu Ile Pro Thr Val 
1               5                   10                  15      


Met Ala 
        


