                         SEQUENCE LISTING

<110>  Stealthyx Therapeutics Limited
 
<120>  Modified Latency Associated Protein Construct

<130>  P60643WO

<150>  GB 1411506.7
<151>  2014-06-27

<160>  144   

<170>  PatentIn version 3.3

<210>  1
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Pro Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Ile Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Gly Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Trp Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln Lys Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  2
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  2

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                 120                 125             


Ile Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                 150                 155                 160 


Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                 170                 175     


Leu Ile Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                 185                 190         


Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 
        195                 200                 205             


Glu Trp Leu His His Lys Asp Arg Trp Leu Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                 250                 255     


Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                 265                 270         


Lys Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                 280                 285             


Tyr Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu 
    290                 295                 300                 


Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                 310                 315                 320 


Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 
                325                 330                 335     


Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                 345                 350         


Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn 
        355                 360                 365             


Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 
    370                 375                 380                 


Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Ile Pro Lys Ile 
385                 390                 395                 400 


Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410                 


<210>  3
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Met His Leu Gln Arg Ala Leu Val Val Leu Ala Leu Leu His 
1               5                   10                  15      


Phe Ala Thr Val Ser Leu Ser Leu Ser Thr Cys Thr Thr Leu Asp Phe 
            20                  25                  30          


Gly His Ile Lys Lys Lys Arg Val Glu Ala Ile Arg Gly Gln Ile Leu 
        35                  40                  45              


Ser Lys Leu Arg Leu Thr Ser Pro Pro Glu Pro Thr Val Met Thr His 
    50                  55                  60                  


Val Pro Tyr Gln Val Leu Ala Leu Tyr Asn Ser Thr Arg Glu Leu Leu 
65                  70                  75                  80  


Glu Glu His Gly Glu Arg Lys Glu Glu Gly Cys Thr Gln Glu Asn Thr 
                85                  90                  95      


Glu Ser Glu Tyr Tyr Ala Lys Glu Ile His Lys Phe Asp Met Ile Gln 
            100                 105                 110         


Gly Leu Ala Glu His Asn Glu Leu Ala Val Cys Pro Lys Gly Ile Thr 
        115                 120                 125             


Ser Lys Val Phe Arg Phe Asn Val Ser Ser Val Glu Lys Asn Arg Thr 
    130                 135                 140                 


Asn Leu Phe Arg Ala Glu Phe Arg Val Leu Arg Val Pro Asn Pro Ser 
145                 150                 155                 160 


Ser Lys Arg Asn Glu Gln Arg Ile Glu Leu Phe Gln Ile Leu Arg Pro 
                165                 170                 175     


Asp Glu His Ile Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Leu Pro 
            180                 185                 190         


Thr Arg Gly Thr Ala Glu Trp Leu Ser Phe Asp Val Thr Asp Thr Val 
        195                 200                 205             


Arg Glu Trp Leu Leu Arg Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser 
    210                 215                 220                 


Ile His Cys Pro Cys His Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu 
225                 230                 235                 240 


Asn Ile His Glu Val Met Glu Ile Lys Phe Lys Gly Val Asp Asn Glu 
                245                 250                 255     


Asp Asp His Gly Arg Gly Asp Leu Gly Arg Leu Lys Lys Gln Lys Asp 
            260                 265                 270         


Asn Asn Asn Pro His Leu Ile Leu Met Met Ile Pro Pro His Arg Leu 
        275                 280                 285             


Asp Asn Pro Gly Gln Gly Gly Gln Arg Lys Lys Arg Ala Leu Asp Thr 
    290                 295                 300                 


Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys Val Arg Pro Leu 
305                 310                 315                 320 


Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp Val His Glu Pro 
                325                 330                 335     


Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys Pro Tyr Leu Arg 
            340                 345                 350         


Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu Tyr Asn Thr Leu 
        355                 360                 365             


Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Asp Leu Glu 
    370                 375                 380                 


Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Ile Pro Lys Val Glu Gln 
385                 390                 395                 400 


Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
                405                 410         


<210>  4
<211>  304
<212>  PRT
<213>  Gallus gallus

<400>  4

Met Asp Pro Met Ser Ile Gly Pro Lys Ser Cys Gly Gly Ser Pro Trp 
1               5                   10                  15      


Arg Pro Pro Gly Thr Ala Pro Trp Ser Ile Gly Ser Arg Arg Ala Thr 
            20                  25                  30          


Ala Ser Ser Ser Cys Ser Thr Ser Ser Arg Val Arg Ala Glu Val Gly 
        35                  40                  45              


Gly Arg Ala Leu Leu His Arg Ala Glu Leu Arg His Leu Arg Gln Lys 
    50                  55                  60                  


Ala Ala Ala Asp Ser Ala Gly Thr Glu Gln Arg Leu Glu Leu Tyr Gln 
65                  70                  75                  80  


Gly Tyr Gly Asn Ala Ser Trp Arg Tyr Leu His Gly Arg Ser Val Arg 
                85                  90                  95      


Ala Thr Ala Asp Asp Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val 
            100                 105                 110         


His Gln Trp Leu Ser Gly Ser Glu Leu Ile Gly Val Phe Lys Leu Ser 
        115                 120                 125             


Val His Cys Pro Cys Glu Met Gly Pro Gly His Ala Asp Glu Met Arg 
    130                 135                 140                 


Ile Ser Ile Glu Gly Phe Glu Gln Gln Arg Gly Asp Met Gln Ser Ile 
145                 150                 155                 160 


Ala Lys Lys His Arg Arg Val Pro Tyr Val Leu Ala Met Ala Leu Pro 
                165                 170                 175     


Ala Glu Arg Ala Asn Glu Leu His Ser Ala Arg Arg Arg Arg Asp Leu 
            180                 185                 190         


Asp Thr Asp Tyr Cys Phe Gly Pro Gly Thr Asp Glu Lys Asn Cys Cys 
        195                 200                 205             


Val Arg Pro Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gln Trp Lys Trp 
    210                 215                 220                 


Ile His Glu Pro Lys Gly Tyr Met Ala Asn Phe Cys Met Gly Pro Cys 
225                 230                 235                 240 


Pro Tyr Ile Trp Ser Ala Asp Thr Gln Tyr Ile Lys Val Leu Ala Leu 
                245                 250                 255     


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 
            260                 265                 270         


Gln Ile Leu Asp Pro Leu Pro Ile Ile Tyr Tyr Val Gly Arg Asn Val 
        275                 280                 285             


Arg Val Glu Gln Leu Ser Asn Met Val Val Arg Ala Cys Lys Cys Ser 
    290                 295                 300                 


<210>  5
<211>  383
<212>  PRT
<213>  Xenopus laevis

<400>  5

Met Glu Val Leu Trp Met Leu Leu Val Leu Leu Val Leu His Leu Ser 
1               5                   10                  15      


Ser Leu Ala Asn Ser Leu Ser Thr Cys Lys Ala Val Asp Met Glu Glu 
            20                  25                  30          


Val Arg Lys Arg Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys 
        35                  40                  45              


Leu Lys Leu Asp Lys Ile Pro Asp Val Asp Ser Glu Lys Met Thr Val 
    50                  55                  60                  


Pro Ser Glu Ala Ile Phe Leu Tyr Asn Ser Thr Leu Glu Val Ile Arg 
65                  70                  75                  80  


Glu Lys Ala Thr Arg Glu Glu Glu Glu His Val Gly His Asp Gln Asn 
                85                  90                  95      


Ile Gln Asp Tyr Tyr Ala Lys Gln Val Tyr Arg Phe Glu Ser Ile Thr 
            100                 105                 110         


Glu Leu Glu Asp His Glu Phe Lys Phe Lys Phe Asn Ala Ser His Val 
        115                 120                 125             


Arg Glu Asn Val Gly Met Asn Ser Leu Leu His His Ala Glu Leu Arg 
    130                 135                 140                 


Met Tyr Lys Lys Gln Thr Asp Lys Asn Met Asp Gln Arg Met Glu Leu 
145                 150                 155                 160 


Phe Trp Lys Tyr Gln Glu Asn Gly Thr Thr His Ser Arg Tyr Leu Glu 
                165                 170                 175     


Ser Lys Tyr Ile Thr Pro Val Thr Asp Gln Glu Trp Asn Ser Phe Asp 
            180                 185                 190         


Val Thr Lys Thr Val Asn Glu Trp Leu Lys Arg Ala Glu Glu Asn Glu 
        195                 200                 205             


Gln Phe Gly Leu Gln Pro Ala Gly Lys Gly Pro Thr Pro Gln Ala Lys 
    210                 215                 220                 


Asp Ile Asp Ile Glu Gly Phe Pro Ala Leu Arg Gly Asp Leu Ala Ser 
225                 230                 235                 240 


Leu Ser Ser Lys Glu Asn Thr Lys Pro Tyr Leu Met Ile Thr Ser Met 
                245                 250                 255     


Pro Ala Glu Arg Ile Asp Thr Val Thr Ser Ser Arg Lys Lys Arg Gly 
            260                 265                 270         


Val Gly Gln Glu Tyr Cys Phe Gly Asn Asn Gly Pro Asn Cys Cys Val 
        275                 280                 285             


Lys Pro Leu Tyr Ile Asn Phe Arg Lys Asp Leu Gly Trp Lys Trp Ile 
    290                 295                 300                 


His Glu Pro Lys Gly Tyr Glu Ala Asn Tyr Cys Leu Gly Asn Cys Pro 
305                 310                 315                 320 


Tyr Ile Trp Ser Met Asp Thr Gln Tyr Ser Lys Val Leu Ser Leu Tyr 
                325                 330                 335     


Asn Gln His Asn Pro Gly Ala Ser Ile Ser Pro Cys Cys Val Pro Asp 
            340                 345                 350         


Val Leu Glu Pro Leu Pro Ile Ile Tyr Tyr Val Gly Arg Ile Ala Lys 
        355                 360                 365             


Val Glu Gln Leu Ser Asn Met Val Val Arg Ser Cys Asn Cys Ser 
    370                 375                 380             


<210>  6
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Pro Gln Gly Ile Ala Gly Gln 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Pro Gln Gly Leu Leu Gly Ala 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Pro Gln Gly Leu Ala Gly Gln 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Pro Leu Gly Ile Ala Gly Ile 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Pro Glu Gly Leu Arg Val Gly 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Rattus sp.

<400>  11

Ala Ala Tyr His Leu Val Ser Gln 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Rattus sp.

<400>  12

Met Asp Ala Phe Leu Glu Ser Ser 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Rattus sp.

<400>  13

Glu Pro Gln Ala Leu Ala Met Ser 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Rattus sp.

<400>  14

Gln Ala Leu Ala Met Ser Ala Ile 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Gallus gallus

<400>  15

Pro Ser Tyr Phe Leu Asn Ala Gly 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  16

Tyr Glu Ala Gly Leu Gly Val Val 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Gly Leu Gly Val Val Glu Arg 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Gly Leu Gly Ile Ser Ser Thr 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Ala Met Phe Leu Glu Ala Ile 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  20

Ile Pro Glu Asn Phe Phe Gly Val 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  21

Thr Glu Gly Glu Ala Arg Gly Ser 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Ala Ile His Ile Gln Ala Glu 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  23

Leu Arg Ala Tyr Leu Leu Pro Ala 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Cavia porcellus

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Hyp

<400>  24

Gly Ala Xaa Gly Leu Glx Gly His 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Rattus sp.

<400>  25

Gly Pro Gln Gly Val Arg Gly Glu 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Rattus sp.

<400>  26

Gly Pro Ala Gly Val Gln Gly Pro 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Rattus sp.

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is Hyp

<400>  27

Gly Pro Ser Gly Leu Xaa Gly Pro 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Rattus sp.

<400>  28

Gly Pro Ala Gly Glu Arg Gly Ser 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Rattus sp.

<400>  29

Gly Ala Lys Gly Leu Thr Gly Ser 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Rattus sp.

<400>  30

Gly Pro Ala Gly Gln Asp Gly Pro 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Rattus sp.

<400>  31

Gly Pro Ala Gly Phe Ala Gly Pro 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Rattus sp.

<400>  32

Gly Pro Ile Gly Asn Val Gly Ala 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Rattus sp.

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Hyl

<400>  33

Gly Pro Lys Gly Ser Arg Gly Ala 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Bos taurus

<400>  34

Gly Pro Gln Gly Ile Ala Gly Gln 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Bos taurus

<400>  35

Gly Pro Gln Gly Leu Leu Gly Ala 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  36

Ile Pro Glu Asn Phe Phe Gly Val 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  37

Pro Pro Gly Ala Tyr His Gly Ala 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  38

Arg Ala Ile His Ile Gln Ala Glu 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  39

Gly Pro His Leu Leu Val Glu Ala 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  40

Leu Arg Ala Tyr Leu Leu Pro Ala 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Pro Glu Gly Leu Arg Val Gly 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  42

Arg Val Gly Phe Tyr Glu Ser Asp 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  43

Leu Leu Ser Ala Leu Val Glu Thr 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  44

Glu Ala Ile Pro Met Ser Ile Pro 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  45

Ile Ala Gly Arg Ser Leu Asn Pro 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Gallus gallus

<400>  46

Leu Asn Ala Gly Phe Thr Ala Ser 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  47

Ile Pro Glu Asn Phe Phe Gly Val 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  48

Lys Pro Gln Gln Phe Phe Gly Leu 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Val Ala Gln Phe Val Leu Thr 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  50

Asp Thr Leu Glu Val Met Arg Lys 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  51

Asp Val Gly His Phe Arg Thr Phe 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  52

Asp Ser Gly Gly Phe Met Leu Thr 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  53

Arg Val Ala Glu Met Arg Gly Glu 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  54

Asp Leu Gly Arg Phe Gln Thr Phe 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  55

Pro Phe Ser Pro Leu Val Ala Thr 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  56

Leu Arg Ala Tyr Leu Leu Pro Ala 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  57

Ala Pro Gly Asn Ala Ser Glu Ser 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  58

Phe Ser Ser Glu Ser Lys Arg Glu 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Bos taurus

<400>  59

Ala Gly Gly Ala Gln Met Gly Val 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Bos taurus

<400>  60

Gln Met Gly Val Met Gln Gly Pro 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Bos taurus

<400>  61

Met Ala Ala Ser Leu Lys Arg Pro 
1               5               


<210>  62
<211>  4
<212>  PRT
<213>  Bos taurus

<400>  62

Ala Lys Arg Glu 
1               


<210>  63
<211>  4
<212>  PRT
<213>  Bos taurus

<400>  63

Leu Arg Lys Pro 
1               


<210>  64
<211>  8
<212>  PRT
<213>  Bos taurus

<400>  64

Gln Ala Gln Ala Ile Leu Gln Gln 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  65

Arg Ala Ile His Ile Gln Ala Glu 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Bos taurus

<400>  66

Leu Val Glu Ala Leu Tyr Leu Val 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Bos taurus

<400>  67

Glu Ala Leu Tyr Leu Val Cys Gly 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  68

Ile Pro Glu Asn Phe Phe Gly Val 
1               5               


<210>  69
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  69

Gly Pro His Leu Leu Val Glu Ala 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  70

Pro Pro Glu Glu Leu Lys Phe Gln 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  71

Gly Pro Pro Gly Val Val Gly Pro 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  72

Gly Pro Pro Gly Leu Arg Gly Glu 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  73

Gly Pro Gly Gly Val Val Gly Glu 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  74

Ile Pro Glu Asn Phe Phe Gly Val 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  75

Pro Pro Gly Ala Tyr His Gly Ala 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  76

Arg Ala Ile His Ile Gln Ala Glu 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  77

Arg Ala Ile His Ile Gln Ala Glu 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  78

Gly Pro His Leu Leu Val Glu Ala 
1               5               


<210>  79
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  79

Met Met Phe Lys Gly Gln Arg Val Glu Arg Val Leu Thr 
1               5                   10              


<210>  80
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  80

His Asn Glu Phe Arg Gln Arg Glu Thr Tyr Met Val Phe 
1               5                   10              


<210>  81
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  81

Asn Trp Gln Glu Phe Gln Ala Lys Arg Ser Val Ala Tyr 
1               5                   10              


<210>  82
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  82

Leu Glu Leu Lys Ser Asn Ser Val Ile Met Arg Trp Pro 
1               5                   10              


<210>  83
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  83

Asp Tyr Met Glu Val Arg Arg Gln Met Ser Met Gln Met 
1               5                   10              


<210>  84
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  84

Ala Leu Glu Met Arg Ala Ala Asp Val Glu Tyr His Phe 
1               5                   10              


<210>  85
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  85

Val Glu His Leu Met Glu Val Gln Arg Lys Thr Thr Trp 
1               5                   10              


<210>  86
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  86

Gly Val Glu Val Lys Arg Gln Leu Ser Tyr His Tyr Met 
1               5                   10              


<210>  87
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  87

Gln Glu Leu Val Gly Ala Asn Ile Glu Thr Tyr Met Leu 
1               5                   10              


<210>  88
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  88

Gln Gln Met Glu Val Ser Arg Tyr Val Gln Tyr Lys Trp 
1               5                   10              


<210>  89
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  89

Leu Gln Ser Phe Arg Gln Ala Pro Val Asp Ile Trp Trp 
1               5                   10              


<210>  90
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  90

Gln Glu Leu Arg Gly Lys Ile Ser Ile Gln Pro Phe Lys 
1               5                   10              


<210>  91
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  91

Gln Gln Glu Tyr Met Ser Gly Gln Tyr Asp Ile Ile Phe 
1               5                   10              


<210>  92
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  92

Ser Met Glu Phe Ala Ala Thr Val Thr Ser Thr Phe Glu 
1               5                   10              


<210>  93
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  93

Glu Gln Gln Leu Lys Gly Arg Gln Thr His Ile Ile Ile 
1               5                   10              


<210>  94
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  94

Met Glu Leu Lys Gly Gln Thr Asp Met Phe Tyr Ile Ile 
1               5                   10              


<210>  95
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  95

Gly Ala Tyr Ala Val Gly Arg Trp Ser Tyr Val Asp Ala 
1               5                   10              


<210>  96
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  96

Gly Gln Phe Ala Thr Ser Pro Lys Ile Thr Ile His Lys 
1               5                   10              


<210>  97
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  97

Asp Val Gln Glu Phe Arg Gly Val Thr Ala Val Ile Arg 
1               5                   10              


<210>  98
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  98

His Glu Ala Arg Thr Val Ser Thr Thr Tyr Leu Met Leu 
1               5                   10              


<210>  99
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  99

Tyr Met Glu Met Arg Gly Ser Thr Thr Val Phe Phe Asn 
1               5                   10              


<210>  100
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  100

Gln Glu Leu Ile Gly Ser Tyr Ser Val Met Pro Thr Asn 
1               5                   10              


<210>  101
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  101

His Tyr Tyr Met Glu Ala Thr Arg Asp Ile Glu Met Val 
1               5                   10              


<210>  102
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  102

Asn Glu Ala His Ser Ser Gly Ile Thr Ile Met Leu Arg 
1               5                   10              


<210>  103
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  103

Asp His Pro Met Glu Phe Arg Ser Lys Ile Thr Met Lys 
1               5                   10              


<210>  104
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  104

Thr Phe Ala Glu Met Lys Gly Thr Val Ser Tyr Ala Leu 
1               5                   10              


<210>  105
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  105

Gly Val His Met Glu Ser Met Arg Arg Tyr Thr Val Ile 
1               5                   10              


<210>  106
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  106

Phe Gln Glu Tyr Thr Gly Thr Tyr Asp Ile Met Asp Pro 
1               5                   10              


<210>  107
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  107

Phe Gln Ala Val Glu Ala Ser Lys Thr Leu His Phe Trp 
1               5                   10              


<210>  108
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  108

Tyr Leu Glu Thr Ser Arg Thr Tyr Thr Thr Val Trp Pro 
1               5                   10              


<210>  109
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  109

Thr Asp Tyr Leu Glu Val Arg Ser Gln Pro Ile Ile Tyr 
1               5                   10              


<210>  110
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  110

Thr Phe Glu Gln Glu Val Arg Ala Pro Asn Ile Ser Trp 
1               5                   10              


<210>  111
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  111

Pro Gln Glu Val Gln Gly Ile Ala Val Glu Trp Val 
1               5                   10          


<210>  112
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  112

Ala Glu Ala Lys Ala Ser Thr Leu His Val Tyr Leu Met 
1               5                   10              


<210>  113
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  113

Asp Tyr Met Glu Val Val Gly Asn Lys Ile Ser Tyr Ile 
1               5                   10              


<210>  114
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  114

Val Ile Met Glu Ala Val Gly Arg Lys Thr Ile Leu Gln 
1               5                   10              


<210>  115
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  115

Phe Gln Ala Glu Ala Ala Arg Ala Val Thr Tyr Ser Ser 
1               5                   10              


<210>  116
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  116

Glu Asp Tyr Val Tyr Val Lys Asp Val Gly Thr Thr Asn 
1               5                   10              


<210>  117
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  117

Gln Glu Tyr Lys Ala His His Ser Tyr Lys Leu Met Ser 
1               5                   10              


<210>  118
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  118

Tyr Asn Glu Tyr Arg Ala Thr Pro Thr Phe Ala Val Val 
1               5                   10              


<210>  119
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  119

Glu Tyr Phe His Ala Asn Thr Thr Arg Ile Val Gln Ser 
1               5                   10              


<210>  120
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  120

Ala Leu Glu Ala Ser Arg Phe Ile Ser Trp Asp Ile Asn 
1               5                   10              


<210>  121
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  121

Trp Glu Ala Val Ala Ala Pro Ile Met His Thr Trp Val 
1               5                   10              


<210>  122
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  122

Phe Gln Glu Leu Lys Ala Ala Glu Thr Phe Trp Met 
1               5                   10          


<210>  123
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  123

Asn Thr Leu Tyr Ala Val Ala Pro Pro Val Ile Tyr Val 
1               5                   10              


<210>  124
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  124

Phe Gln Pro Tyr Glu Val Gln Arg Ile Thr Thr Val Met 
1               5                   10              


<210>  125
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  125

Lys Pro Met Glu Ser Gly Arg Arg Thr Thr Val Tyr Tyr 
1               5                   10              


<210>  126
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  126

Met Glu Phe Lys Gly Ala Leu Gln Tyr Arg Leu Gln Pro 
1               5                   10              


<210>  127
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  127

Pro Gln Glu Val Lys Gln Ala Arg Lys Trp Ile Ile Glu 
1               5                   10              


<210>  128
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Protein cleavage site of ADAMTS-4 (aggrecanase-1) 

<400>  128

Tyr Arg Gln Gln Glu Val Lys Arg His Ile Gln Ile Val 
1               5                   10              


<210>  129
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Consensus ADAMTS-4 cleavage motif


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Ala, Phe, Val, Leu, Met, or Tyr

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  May be present or absent. If present, Xaa indicates no obvious 
       consensus

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Arg or Lys

<220>
<221>  VARIANT
<222>  (5)..(7)
<223>  Any 1 Xaa may be present or absent: represents a range of 2-3 
       amino acids. If present, Xaa indicates no obvious consensus

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Ser or Thr

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is Val, Tyr, Ile, Phe, Trp, Met, Leu, or Ala

<400>  129

Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  130
<211>  2037
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Mouse lG1(Fc)-LAP-MMP-IFN

<220>
<221>  CDS
<222>  (1)..(2028)

<400>  130
gga tcc acc atg tac agg atg caa ctc ctg tgc att gca cta agt ctt       48
Gly Ser Thr Met Tyr Arg Met Gln Leu Leu Cys Ile Ala Leu Ser Leu         
1               5                   10                  15              

gca ctt gtc acg aat tcc ggt tgt aag cct tgc ata tgt aca gtc cca       96
Ala Leu Val Thr Asn Ser Gly Cys Lys Pro Cys Ile Cys Thr Val Pro         
            20                  25                  30                  

gaa gta tca tct gtc ttc atc ttc ccc cca aag ccc aag gat gtg ctc      144
Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu         
        35                  40                  45                      

acc att act ctg act cct aag gtc acg tgt gtt gtg gta gac atc agc      192
Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser         
    50                  55                  60                          

aag gat gat ccc gag gtc cag ttc agc tgg ttt gta gat gat gtg gag      240
Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu         
65                  70                  75                  80          

gtg cac aca gct cag acg caa ccc cgg gag gag cag ttc aac agc act      288
Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr         
                85                  90                  95              

ttc cgc tca gtc agt gaa ctt ccc atc atg cac cag gac tgg ctc aat      336
Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn         
            100                 105                 110                 

ggc aag gag ttc aaa tgc agg gtc aac agt gca gct ttc cct gcc ccc      384
Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro         
        115                 120                 125                     

atc gag aaa acc atc tcc aaa acc aaa ggc aga ccg aag gct cca cag      432
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln         
    130                 135                 140                         

gtg tac acc att cca cct ccc aag gag cag atg gcc aag gat aaa gtc      480
Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val         
145                 150                 155                 160         

agt ctg acc tgc atg ata aca gac ttc ttc cct gaa gac att act gtg      528
Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val         
                165                 170                 175             

gag tgg cag tgg aat ggg cag cca gcg gag aac tac aag aac act cag      576
Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln         
            180                 185                 190                 

ccc atc atg gac aca gat ggc tct tac ttc gtc tac agc aag ctc aat      624
Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn         
        195                 200                 205                     

gtg cag aag agc aac tgg gag gca gga aat act ttc acc tgc tct gtg      672
Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val         
    210                 215                 220                         

tta cat gag ggc ctg cac aac cac cat act gag aag agc ctc tcc cac      720
Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His         
225                 230                 235                 240         

tct cct ggt aaa aag ctt cca tgg agg aat tcc tcc acc agc aag acc      768
Ser Pro Gly Lys Lys Leu Pro Trp Arg Asn Ser Ser Thr Ser Lys Thr         
                245                 250                 255             

atc gac atg gag ctg gtg aaa cgg aag cgc atc gaa gcc atc cgt ggc      816
Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala Ile Arg Gly         
            260                 265                 270                 

cag atc ctg tcc aaa cta agg ctc gcc agt ccc cca agc cag ggg gag      864
Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser Gln Gly Glu         
        275                 280                 285                     

gta ccg ccc ggc ccg ctg ccc gag gcg gtg ctc gct ttg tac aac agc      912
Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu Tyr Asn Ser         
    290                 295                 300                         

acc cgc gac cgg gtg gca ggc gag agc gcc gac cca gag ccg gag ccc      960
Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Asp Pro Glu Pro Glu Pro         
305                 310                 315                 320         

gaa gcg gac tac tat gct aaa gag gtc acc cgc gtg cta atg gtg gac     1008
Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu Met Val Asp         
                325                 330                 335             

cgc aac aac gcc atc tat gag aaa acc aaa gac atc tca cac agt ata     1056
Arg Asn Asn Ala Ile Tyr Glu Lys Thr Lys Asp Ile Ser His Ser Ile         
            340                 345                 350                 

tat atg ttc ttc aat acg tca gac att cgg gaa gca gtg ccc gaa ccc     1104
Tyr Met Phe Phe Asn Thr Ser Asp Ile Arg Glu Ala Val Pro Glu Pro         
        355                 360                 365                     

cca ttg ctg tcc cgt gca gag ctg cgc ttg cag aga tta aaa tca agt     1152
Pro Leu Leu Ser Arg Ala Glu Leu Arg Leu Gln Arg Leu Lys Ser Ser         
    370                 375                 380                         

gtg gag caa cat gtg gaa ctc tac cag aaa tat agc aac aat tcc tgg     1200
Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn Asn Ser Trp         
385                 390                 395                 400         

cgt tac ctt ggt aac cgg ctg ctg acc ccc act gat acg cct gag tgg     1248
Arg Tyr Leu Gly Asn Arg Leu Leu Thr Pro Thr Asp Thr Pro Glu Trp         
                405                 410                 415             

ctg tct ttt gac gtc act gga gtt gta cgg cag tgg ctg aac caa gga     1296
Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu Asn Gln Gly         
            420                 425                 430                 

gac gga ata cag ggc ttt cga ttc agc gct cac tgc tct tgt gac agc     1344
Asp Gly Ile Gln Gly Phe Arg Phe Ser Ala His Cys Ser Cys Asp Ser         
        435                 440                 445                     

aaa gat aac aaa ctc cac gtg gaa atc aac ggg atc agc ccc aaa cgt     1392
Lys Asp Asn Lys Leu His Val Glu Ile Asn Gly Ile Ser Pro Lys Arg         
    450                 455                 460                         

cgg ggc gac ctg ggc acc atc cat gac atg aac cgg ccc ttc ctg ctc     1440
Arg Gly Asp Leu Gly Thr Ile His Asp Met Asn Arg Pro Phe Leu Leu         
465                 470                 475                 480         

ctc atg gcc acc ccc ctg gaa agg gcc cag cac ctg cac agc ctg cag     1488
Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu His Ser Leu Gln         
                485                 490                 495             

ggg gga ggc ggt tcc ccg ctc ggg ctt tgg gcg gga ggg ggc tca gcg     1536
Gly Gly Gly Gly Ser Pro Leu Gly Leu Trp Ala Gly Gly Gly Ser Ala         
            500                 505                 510                 

gcc gca atc aac tat aag cag ctc cag ctc caa gaa agg acg aac att     1584
Ala Ala Ile Asn Tyr Lys Gln Leu Gln Leu Gln Glu Arg Thr Asn Ile         
        515                 520                 525                     

cgg aaa tgt cag gag ctc ctg gag cag ctg aat gga aag atc aac ctc     1632
Arg Lys Cys Gln Glu Leu Leu Glu Gln Leu Asn Gly Lys Ile Asn Leu         
    530                 535                 540                         

acc tac agg gcg gac ttc aag atc cct atg gag atg acg gag aag atg     1680
Thr Tyr Arg Ala Asp Phe Lys Ile Pro Met Glu Met Thr Glu Lys Met         
545                 550                 555                 560         

cag aag agt tac act gcc ttt gcc atc caa gag atg ctc cag aat gtc     1728
Gln Lys Ser Tyr Thr Ala Phe Ala Ile Gln Glu Met Leu Gln Asn Val         
                565                 570                 575             

ttt ctt gtc ttc aga aac aat ttc tcc agc act ggg tgg aat gag act     1776
Phe Leu Val Phe Arg Asn Asn Phe Ser Ser Thr Gly Trp Asn Glu Thr         
            580                 585                 590                 

att gtt gta cgt ctc ctg gat gaa ctc cac cag cag aca gtg ttt ctg     1824
Ile Val Val Arg Leu Leu Asp Glu Leu His Gln Gln Thr Val Phe Leu         
        595                 600                 605                     

aag aca gta cta gag gaa aag caa gag gaa aga ttg acg tgg gag atg     1872
Lys Thr Val Leu Glu Glu Lys Gln Glu Glu Arg Leu Thr Trp Glu Met         
    610                 615                 620                         

tcc tca act gct ctc cac ttg aag agc tat tac tgg agg gtg caa agg     1920
Ser Ser Thr Ala Leu His Leu Lys Ser Tyr Tyr Trp Arg Val Gln Arg         
625                 630                 635                 640         

tac ctt aaa ctc atg aag tac aac agc tac gcc tgg atg gtg gtc cga     1968
Tyr Leu Lys Leu Met Lys Tyr Asn Ser Tyr Ala Trp Met Val Val Arg         
                645                 650                 655             

gca gag atc ttc agg aac ttt ctc atc att cga aga ctt acc aga aac     2016
Ala Glu Ile Phe Arg Asn Phe Leu Ile Ile Arg Arg Leu Thr Arg Asn         
            660                 665                 670                 

ttc caa aac tga atctagacc                                           2037
Phe Gln Asn                                                             
        675                                                             


<210>  131
<211>  675
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  131

Gly Ser Thr Met Tyr Arg Met Gln Leu Leu Cys Ile Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Val Thr Asn Ser Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            20                  25                  30          


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        35                  40                  45              


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    50                  55                  60                  


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
65                  70                  75                  80  


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                85                  90                  95      


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            100                 105                 110         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        115                 120                 125             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    130                 135                 140                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
145                 150                 155                 160 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                165                 170                 175     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            180                 185                 190         


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        195                 200                 205             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    210                 215                 220                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
225                 230                 235                 240 


Ser Pro Gly Lys Lys Leu Pro Trp Arg Asn Ser Ser Thr Ser Lys Thr 
                245                 250                 255     


Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala Ile Arg Gly 
            260                 265                 270         


Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser Gln Gly Glu 
        275                 280                 285             


Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu Tyr Asn Ser 
    290                 295                 300                 


Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Asp Pro Glu Pro Glu Pro 
305                 310                 315                 320 


Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu Met Val Asp 
                325                 330                 335     


Arg Asn Asn Ala Ile Tyr Glu Lys Thr Lys Asp Ile Ser His Ser Ile 
            340                 345                 350         


Tyr Met Phe Phe Asn Thr Ser Asp Ile Arg Glu Ala Val Pro Glu Pro 
        355                 360                 365             


Pro Leu Leu Ser Arg Ala Glu Leu Arg Leu Gln Arg Leu Lys Ser Ser 
    370                 375                 380                 


Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn Asn Ser Trp 
385                 390                 395                 400 


Arg Tyr Leu Gly Asn Arg Leu Leu Thr Pro Thr Asp Thr Pro Glu Trp 
                405                 410                 415     


Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu Asn Gln Gly 
            420                 425                 430         


Asp Gly Ile Gln Gly Phe Arg Phe Ser Ala His Cys Ser Cys Asp Ser 
        435                 440                 445             


Lys Asp Asn Lys Leu His Val Glu Ile Asn Gly Ile Ser Pro Lys Arg 
    450                 455                 460                 


Arg Gly Asp Leu Gly Thr Ile His Asp Met Asn Arg Pro Phe Leu Leu 
465                 470                 475                 480 


Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu His Ser Leu Gln 
                485                 490                 495     


Gly Gly Gly Gly Ser Pro Leu Gly Leu Trp Ala Gly Gly Gly Ser Ala 
            500                 505                 510         


Ala Ala Ile Asn Tyr Lys Gln Leu Gln Leu Gln Glu Arg Thr Asn Ile 
        515                 520                 525             


Arg Lys Cys Gln Glu Leu Leu Glu Gln Leu Asn Gly Lys Ile Asn Leu 
    530                 535                 540                 


Thr Tyr Arg Ala Asp Phe Lys Ile Pro Met Glu Met Thr Glu Lys Met 
545                 550                 555                 560 


Gln Lys Ser Tyr Thr Ala Phe Ala Ile Gln Glu Met Leu Gln Asn Val 
                565                 570                 575     


Phe Leu Val Phe Arg Asn Asn Phe Ser Ser Thr Gly Trp Asn Glu Thr 
            580                 585                 590         


Ile Val Val Arg Leu Leu Asp Glu Leu His Gln Gln Thr Val Phe Leu 
        595                 600                 605             


Lys Thr Val Leu Glu Glu Lys Gln Glu Glu Arg Leu Thr Trp Glu Met 
    610                 615                 620                 


Ser Ser Thr Ala Leu His Leu Lys Ser Tyr Tyr Trp Arg Val Gln Arg 
625                 630                 635                 640 


Tyr Leu Lys Leu Met Lys Tyr Asn Ser Tyr Ala Trp Met Val Val Arg 
                645                 650                 655     


Ala Glu Ile Phe Arg Asn Phe Leu Ile Ile Arg Arg Leu Thr Arg Asn 
            660                 665                 670         


Phe Gln Asn 
        675 


<210>  132
<211>  2370
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Human lg Lap with anti-herNeu2 (Herceptin) 
       antibody

<220>
<221>  CDS
<222>  (1)..(2370)

<400>  132
atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt       48
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu         
1               5                   10                  15              

gtc acg aat tcc gag ccc aaa tct tgt gac aaa act cac aca tgc cca       96
Val Thr Asn Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro         
            20                  25                  30                  

ccg tgc cca gca cct gaa gct gcg ggg gga ccg tca gtc ttc ctc ttc      144
Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe         
        35                  40                  45                      

ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc      192
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val         
    50                  55                  60                          

aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc      240
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe         
65                  70                  75                  80          

aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg      288
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro         
                85                  90                  95              

cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc      336
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr         
            100                 105                 110                 

gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc      384
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val         
        115                 120                 125                     

tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc      432
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala         
    130                 135                 140                         

aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg      480
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg         
145                 150                 155                 160         

gag gag atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc      528
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly         
                165                 170                 175             

ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg      576
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro         
            180                 185                 190                 

gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc      624
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser         
        195                 200                 205                     

ttc ttc ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag      672
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln         
    210                 215                 220                         

ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac      720
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His         
225                 230                 235                 240         

tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa aag ctt cca tgg      768
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Leu Pro Trp         
                245                 250                 255             

agg aat tcc cta tcc acc agt aag act atc gac atg gag ctg gtg aag      816
Arg Asn Ser Leu Ser Thr Ser Lys Thr Ile Asp Met Glu Leu Val Lys         
            260                 265                 270                 

cgg aag cgc atc gag gcc atc cgc ggc cag atc ctg tcc aag ctg cgg      864
Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg         
        275                 280                 285                     

ctc gcc agc ccc ccg agc cag ggg gag gtg ccg ccc ggc ccg ctg ccc      912
Leu Ala Ser Pro Pro Ser Gln Gly Glu Val Pro Pro Gly Pro Leu Pro         
    290                 295                 300                         

gag gcc gtg ctc gcc ctg tac aac agc acc cgc gac cgg gtg gcc ggg      960
Glu Ala Val Leu Ala Leu Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly         
305                 310                 315                 320         

gag agt gca gaa ccg gag ccc gag cct gag gcc gac tac tac gcc aag     1008
Glu Ser Ala Glu Pro Glu Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys         
                325                 330                 335             

gag gtc acc cgc gtg cta atg gtg gaa acc cac aac gaa atc tat gac     1056
Glu Val Thr Arg Val Leu Met Val Glu Thr His Asn Glu Ile Tyr Asp         
            340                 345                 350                 

aag ttc aag cag agt aca cac agc ata tat atg ttc ttc aac aca tca     1104
Lys Phe Lys Gln Ser Thr His Ser Ile Tyr Met Phe Phe Asn Thr Ser         
        355                 360                 365                     

gag ctc cga gaa gcg gta cct gaa ccc gtg ttg ctc tcc cgg gca gag     1152
Glu Leu Arg Glu Ala Val Pro Glu Pro Val Leu Leu Ser Arg Ala Glu         
    370                 375                 380                         

ctg cgt ctg ctg agg ctc aag tta aaa gtg gag cag cac gtg gag ctg     1200
Leu Arg Leu Leu Arg Leu Lys Leu Lys Val Glu Gln His Val Glu Leu         
385                 390                 395                 400         

tac cag aaa tac agc aac aat tcc tgg cga tac ctc agc aac cgg ctg     1248
Tyr Gln Lys Tyr Ser Asn Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu         
                405                 410                 415             

ctg gca ccc agc gac tcg cca gag tgg tta tct ttt gat gtc acc gga     1296
Leu Ala Pro Ser Asp Ser Pro Glu Trp Leu Ser Phe Asp Val Thr Gly         
            420                 425                 430                 

gtt gtg cgg cag tgg ttg agc cgt gga ggg gaa att gag ggc ttt cgc     1344
Val Val Arg Gln Trp Leu Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg         
        435                 440                 445                     

ctt agc gcc cac tgc tcc tgt gac agc agg gat aac aca ctg caa gtg     1392
Leu Ser Ala His Cys Ser Cys Asp Ser Arg Asp Asn Thr Leu Gln Val         
    450                 455                 460                         

gac atc aac ggg ttc act acc ggc cgc cga ggt gac ctg gcc acc att     1440
Asp Ile Asn Gly Phe Thr Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile         
465                 470                 475                 480         

cat ggc atg aac cgg cct ttc ctg ctt ctc atg gcc acc ccg ctg gag     1488
His Gly Met Asn Arg Pro Phe Leu Leu Leu Met Ala Thr Pro Leu Glu         
                485                 490                 495             

agg gcc cag cat ctg caa agc ctg cag gga ggc ggg ggt tca gac gtc     1536
Arg Ala Gln His Leu Gln Ser Leu Gln Gly Gly Gly Gly Ser Asp Val         
            500                 505                 510                 

caa gag ttc cgc ggc gtc aca gct gtg atc cgt gga ggc ggg ggt tca     1584
Gln Glu Phe Arg Gly Val Thr Ala Val Ile Arg Gly Gly Gly Gly Ser         
        515                 520                 525                     

gcg gcc cag atg gcc gag gtt cag ctg gtg gag tct ggc ggt ggc ctg     1632
Ala Ala Gln Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu         
    530                 535                 540                         

gtg cag cca ggg ggc tca ctc cgt ttg tcc tgt gca gct tct ggc ttc     1680
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe         
545                 550                 555                 560         

aac att aaa gac acc tat ata cac tgg gtg cgt cag gcc ccg ggt aag     1728
Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys         
                565                 570                 575             

ggc ctg gaa tgg gtt gca agg att tat cct acg aat ggt tat gct aga     1776
Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Ala Arg         
            580                 585                 590                 

tat gcc gat agc gtc aag ggc cgt ttc act ata agc gca gac aca tcc     1824
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser         
        595                 600                 605                     

aaa aac aca gcc tac ctg cag atg aac agc ctg cgt gct gag gac act     1872
Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr         
    610                 615                 620                         

gcc gtc tat tat tgt tct aga tgg gga ggg gac ggc ttc tat gct atg     1920
Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met         
625                 630                 635                 640         

gac tac tgg ggt caa gga acc ctg gtc acc gtc tcc tcg ggc gga ggc     1968
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly         
                645                 650                 655             

gga tcc ggc gga ggc gga tcg gga ggc gga gga tcc gat atc cag atg     2016
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met         
            660                 665                 670                 

acc cag tcc ccg agc tcc ctg tcc gcc tct gtg ggc gat agg gtc acc     2064
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr         
        675                 680                 685                     

atc acc tgc cgt gcc agt cag gat gtg aat act gct gta gcc tgg tat     2112
Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr         
    690                 695                 700                         

caa cag aaa cca gga aaa gct ccg aaa cta ctg att tac tcg gca tcc     2160
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser         
705                 710                 715                 720         

ttc ctc tac tct gga gtc ctt tct cgc ttc tct ggg tcc aga tct ggg     2208
Phe Leu Tyr Ser Gly Val Leu Ser Arg Phe Ser Gly Ser Arg Ser Gly         
                725                 730                 735             

acg gat ttc act ctg acc atc agc agt ctg cag ccg gag gac ttc gca     2256
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala         
            740                 745                 750                 

act tat tac tgt cag caa cat tat act act cct ccc acg ttc gga cag     2304
Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln         
        755                 760                 765                     

ggt acc aag gtg gag atc aaa cgc gcg gat gcg gcc gca ctc gag cac     2352
Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Ala Leu Glu His         
    770                 775                 780                         

cac cac cac cac cac tga                                             2370
His His His His His                                                     
785                                                                     


<210>  133
<211>  789
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  133

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Leu Pro Trp 
                245                 250                 255     


Arg Asn Ser Leu Ser Thr Ser Lys Thr Ile Asp Met Glu Leu Val Lys 
            260                 265                 270         


Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg 
        275                 280                 285             


Leu Ala Ser Pro Pro Ser Gln Gly Glu Val Pro Pro Gly Pro Leu Pro 
    290                 295                 300                 


Glu Ala Val Leu Ala Leu Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly 
305                 310                 315                 320 


Glu Ser Ala Glu Pro Glu Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys 
                325                 330                 335     


Glu Val Thr Arg Val Leu Met Val Glu Thr His Asn Glu Ile Tyr Asp 
            340                 345                 350         


Lys Phe Lys Gln Ser Thr His Ser Ile Tyr Met Phe Phe Asn Thr Ser 
        355                 360                 365             


Glu Leu Arg Glu Ala Val Pro Glu Pro Val Leu Leu Ser Arg Ala Glu 
    370                 375                 380                 


Leu Arg Leu Leu Arg Leu Lys Leu Lys Val Glu Gln His Val Glu Leu 
385                 390                 395                 400 


Tyr Gln Lys Tyr Ser Asn Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu 
                405                 410                 415     


Leu Ala Pro Ser Asp Ser Pro Glu Trp Leu Ser Phe Asp Val Thr Gly 
            420                 425                 430         


Val Val Arg Gln Trp Leu Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg 
        435                 440                 445             


Leu Ser Ala His Cys Ser Cys Asp Ser Arg Asp Asn Thr Leu Gln Val 
    450                 455                 460                 


Asp Ile Asn Gly Phe Thr Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile 
465                 470                 475                 480 


His Gly Met Asn Arg Pro Phe Leu Leu Leu Met Ala Thr Pro Leu Glu 
                485                 490                 495     


Arg Ala Gln His Leu Gln Ser Leu Gln Gly Gly Gly Gly Ser Asp Val 
            500                 505                 510         


Gln Glu Phe Arg Gly Val Thr Ala Val Ile Arg Gly Gly Gly Gly Ser 
        515                 520                 525             


Ala Ala Gln Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
545                 550                 555                 560 


Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Ala Arg 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
        595                 600                 605             


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met 
625                 630                 635                 640 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                645                 650                 655     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
            660                 665                 670         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        675                 680                 685             


Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr 
    690                 695                 700                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
705                 710                 715                 720 


Phe Leu Tyr Ser Gly Val Leu Ser Arg Phe Ser Gly Ser Arg Ser Gly 
                725                 730                 735     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            740                 745                 750         


Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln 
        755                 760                 765             


Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Ala Leu Glu His 
    770                 775                 780                 


His His His His His 
785                 


<210>  134
<211>  2370
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  134
tcagtggtgg tggtggtggt gctcgagtgc ggccgcatcc gcgcgtttga tctccacctt     60

ggtaccctgt ccgaacgtgg gaggagtagt ataatgttgc tgacagtaat aagttgcgaa    120

gtcctccggc tgcagactgc tgatggtcag agtgaaatcc gtcccagatc tggacccaga    180

gaagcgagaa aggactccag agtagaggaa ggatgccgag taaatcagta gtttcggagc    240

ttttcctggt ttctgttgat accaggctac agcagtattc acatcctgac tggcacggca    300

ggtgatggtg accctatcgc ccacagaggc ggacagggag ctcggggact gggtcatctg    360

gatatcggat cctccgcctc ccgatccgcc tccgccggat ccgcctccgc ccgaggagac    420

ggtgaccagg gttccttgac cccagtagtc catagcatag aagccgtccc ctccccatct    480

agaacaataa tagacggcag tgtcctcagc acgcaggctg ttcatctgca ggtaggctgt    540

gtttttggat gtgtctgcgc ttatagtgaa acggcccttg acgctatcgg catatctagc    600

ataaccattc gtaggataaa tccttgcaac ccattccagg cccttacccg gggcctgacg    660

cacccagtgt atataggtgt ctttaatgtt gaagccagaa gctgcacagg acaaacggag    720

tgagccccct ggctgcacca ggccaccgcc agactccacc agctgaacct cggccatctg    780

ggccgctgaa cccccgcctc cacggatcac agctgtgacg ccgcggaact cttggacgtc    840

tgaacccccg cctccctgca ggctttgcag atgctgggcc ctctccagcg gggtggccat    900

gagaagcagg aaaggccggt tcatgccatg aatggtggcc aggtcacctc ggcggccggt    960

agtgaacccg ttgatgtcca cttgcagtgt gttatccctg ctgtcacagg agcagtgggc   1020

gctaaggcga aagccctcaa tttcccctcc acggctcaac cactgccgca caactccggt   1080

gacatcaaaa gataaccact ctggcgagtc gctgggtgcc agcagccggt tgctgaggta   1140

tcgccaggaa ttgttgctgt atttctggta cagctccacg tgctgctcca cttttaactt   1200

gagcctcagc agacgcagct ctgcccggga gagcaacacg ggttcaggta ccgcttctcg   1260

gagctctgat gtgttgaaga acatatatat gctgtgtgta ctctgcttga acttgtcata   1320

gatttcgttg tgggtttcca ccattagcac gcgggtgacc tccttggcgt agtagtcggc   1380

ctcaggctcg ggctccggtt ctgcactctc cccggccacc cggtcgcggg tgctgttgta   1440

cagggcgagc acggcctcgg gcagcgggcc gggcggcacc tccccctggc tcggggggct   1500

ggcgagccgc agcttggaca ggatctggcc gcggatggcc tcgatgcgct tccgcttcac   1560

cagctccatg tcgatagtct tactggtgga tagggaattc ctccatggaa gctttttacc   1620

cggagacagg gagaggctct tctgcgtgta gtggttgtgc agagcctcat gcatcacgga   1680

gcatgagaag acgttcccct gctgccacct gctcttgtcc acggtgagct tgctatagag   1740

gaagaaggag ccgtcggagt ccagcacggg aggcgtggtc ttgtagttgt tctccggctg   1800

cccattgctc tcccactcca cggcgatgtc gctgggatag aagcctttga ccaggcaggt   1860

caggctgacc tggttcttgg tcatctcctc ccgggatggg ggcagggtgt acacctgtgg   1920

ttctcggggc tgccctttgg ctttggagat ggttttctcg atgggggctg ggagggcttt   1980

gttggagacc ttgcacttgt actccttgcc attcagccag tcctggtgca ggacggtgag   2040

gacgctgacc acacggtacg tgctgttgta ctgctcctcc cgcggctttg tcttggcatt   2100

atgcacctcc acgccgtcca cgtaccagtt gaacttgacc tcagggtctt cgtggctcac   2160

gtccaccacc acgcatgtga cctcaggggt ccgggagatc atgagggtgt ccttgggttt   2220

tggggggaag aggaagactg acggtccccc cgcagcttca ggtgctgggc acggtgggca   2280

tgtgtgagtt ttgtcacaag atttgggctc ggaattcgtg acaagtgcaa gacttagtgc   2340

aatgcaagac aggagttgca tcctgtacat                                    2370


<210>  135
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Linker

<400>  135

Gly Gly Gly Gly Ser 
1               5   


<210>  136
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Linker

<400>  136

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  137
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Common sequence motif present in hinge polypeptide region

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa can be another residue that does not interfere with 
       dimerisation, for example proline (P), arginine (R) or serine (S)

<400>  137

Cys Pro Xaa Cys Pro 
1               5   


<210>  138
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  138

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  139
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  139

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  140
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  140

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  141
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  141

Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
1               5                   10                  15  


<210>  142
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  142

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  143
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  143
atgaattccg gttgtaagcc ttgcata                                         27


<210>  144
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  144
gtgaattcct ccatggaagc tttttaccag gagagtggga gag                       43


