                               SEQUENCE LISTING

<110> NOVARTIS AG
 
<120> GDF15 FUSIONS AND METHODS OF USE

<130> PAT056218-WO-PCT

<140> PCT/IB2015/054638
<141> 2015-06-19

<150> 62/015,945
<151> 2014-06-23

<160> 78    

<170> PatentIn version 3.5

<210> 1
<211> 308
<212> PRT
<213> Homo sapiens

<400> 1
Met Pro Gly Gln Glu Leu Arg Thr Val Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Leu Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Gln Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210> 2
<211> 609
<212> PRT
<213> Homo sapiens

<400> 2
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210> 3
<211> 20
<212> PRT
<213> Mus musculus

<400> 3
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210> 4
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 5
<211> 85
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Ala Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Asp Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Ala Ala Ala Leu Pro Leu Ser Asn Ser Thr Asn Asn Gly Leu Ser 
    50                  55                  60                  


Ser Thr Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Gln Leu Asp Lys Arg 
                85  


<210> 6
<211> 414
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 6
atggagacag acacgctgct cctctgggta ttgctgctgt gggtaccagg atccaccggc       60

catcaccacc accatcatgc cagaaacggt gatcattgcc cacttggacc cgggaggtgc      120

tgtcggcttc acactgtcag ggcatcactc gaagatctcg ggtgggcgga ctgggtgctt      180

tcgcccagag aagtgcaagt cactatgtgc attggtgcgt gcccgtcgca attcagagct      240

gccaacatgc atgcccagat caaaacgagc ttgcaccggc tgaaacccga cacagtcccc      300

gctccgtgct gcgtgccggc gtcgtataac cccatggtcc tcatccagaa aaccgatacg      360

ggagtgtcat tgcagacata tgatgacctt ttggccaagg attgccactg tatc            414


<210> 7
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
His His His His His His Ala Arg Asn Gly Asp His Cys Pro Leu Gly 
1               5                   10                  15      


Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp 
            20                  25                  30          


Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr 
        35                  40                  45              


Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His 
    50                  55                  60                  


Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro 
65                  70                  75                  80  


Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln 
                85                  90                  95      


Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala 
            100                 105                 110         


Lys Asp Cys His Cys Ile 
        115             


<210> 8
<211> 450
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 8
atggagacag acacgctgct cctctgggta ttgctgctgt gggtaccagg atccaccggc       60

catcaccacc accatcatca ccacggcgga agcgagaacc tgtacttcca gggcgccaga      120

aacggtgatc attgcccact tggacccggg aggtgctgtc ggcttcacac tgtcagggca      180

tcactcgaag atctcgggtg ggcggactgg gtgctttcgc ccagagaagt gcaagtcact      240

atgtgcattg gtgcgtgccc gtcgcaattc agagctgcca acatgcatgc ccagatcaaa      300

acgagcttgc accggctgaa acccgacaca gtccccgctc cgtgctgcgt gccggcgtcg      360

tataacccca tggtcctcat ccagaaaacc gatacgggag tgtcattgca gacatatgat      420

gaccttttgg ccaaggattg ccactgtatc                                       450


<210> 9
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
His His His His His His His His Gly Gly Ser Glu Asn Leu Tyr Phe 
1               5                   10                  15      


Gln Gly Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys 
            20                  25                  30          


Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala 
        35                  40                  45              


Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly 
    50                  55                  60                  


Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys 
65                  70                  75                  80  


Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys 
                85                  90                  95      


Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr 
            100                 105                 110         


Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His 
        115                 120                 125             


Cys Ile 
    130 


<210> 10
<211> 591
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 10
atgagattcc cttccatctt tacagcagtg ttatttgctg ctagttccgc cctagcagct       60

ccagctaaca cgactactga agatgaaaca gcccaaatcc cagcagaagc tgttattgac      120

tacagcgact tggagggtga cttcgacgca gctgctctcc ccctttctaa ttctactaat      180

aatggactga gttccacaaa tactaccatt gcctcaattg ccgccaagga ggaaggtgtc      240

caactggaca aaagagctag aaatggtgac cactgccctt taggtcccgg cagatgttgt      300

cgtttgcata ctgtgagagc atcactggag gatctaggat gggctgattg ggtgttgtct      360

ccaagggagg ttcaggtaac tatgtgtata ggagcatgcc catcccagtt cagggctgca      420

aacatgcacg ctcaaatcaa aacaagcctt catcgtttga aacctgatac agtaccggca      480

ccatgttgtg ttccagcttc atataaccct atggtcctga tccaaaagac cgacactggt      540

gtttcgttgc aaacgtacga tgatttgttg gctaaggatt gccattgtat t               591


<210> 11
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210> 12
<211> 819
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 12
atgcatcacc atcatcatca ccaaaaacct gttggcgttg aagagccggt ctacgatact       60

gcaggtcgtc ctctttttgg gaatccgtcc gaagtgcacc cccagtcaac cctcaagctt      120

ccccatgacc gcggagaaga tgacattgaa acaacgctgc gcgatctgcc tcgtaaaggc      180

gattgtcgct ctggaaacca cctaggtccg gtgtcgggca tttacattaa accaggtccc      240

gtctattacc aagactacac tggtccggtt taccatcgtg cacctctgga attctttgat      300

gaaacccaat ttgaggaaac cactaaacgt attggccgtg taaccggttc ggacgggaaa      360

ctgtaccaca tctacgtgga ggttgatggc gagatcctgc tgaaacaggc gaagcgcgga      420

acccctcgca ccctgaaatg gacccgtaac accactaact gtccactgtg ggtcactagt      480

tgcgcacgca acggtgatca ttgtccgctg ggtcctggtc gctgctgccg tctgcatacg      540

gtgcgtgcga gcctggaaga tctgggctgg gcagattggg tcctgtcccc acgcgaggtt      600

caagtgacga tgtgcattgg tgcgtgcccg agccagttcc gtgcggccaa catgcacgca      660

cagattaaga cctctctgca ccgtctgaaa ccggacaccg tgccggctcc gtgttgtgtc      720

ccggccagct ataatccgat ggttctgatc caaaagaccg acaccggcgt tagcttgcag      780

acttacgacg atctgttggc gaaagactgt cactgcatc                             819


<210> 13
<211> 273
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Met His His His His His His Gln Lys Pro Val Gly Val Glu Glu Pro 
1               5                   10                  15      


Val Tyr Asp Thr Ala Gly Arg Pro Leu Phe Gly Asn Pro Ser Glu Val 
            20                  25                  30          


His Pro Gln Ser Thr Leu Lys Leu Pro His Asp Arg Gly Glu Asp Asp 
        35                  40                  45              


Ile Glu Thr Thr Leu Arg Asp Leu Pro Arg Lys Gly Asp Cys Arg Ser 
    50                  55                  60                  


Gly Asn His Leu Gly Pro Val Ser Gly Ile Tyr Ile Lys Pro Gly Pro 
65                  70                  75                  80  


Val Tyr Tyr Gln Asp Tyr Thr Gly Pro Val Tyr His Arg Ala Pro Leu 
                85                  90                  95      


Glu Phe Phe Asp Glu Thr Gln Phe Glu Glu Thr Thr Lys Arg Ile Gly 
            100                 105                 110         


Arg Val Thr Gly Ser Asp Gly Lys Leu Tyr His Ile Tyr Val Glu Val 
        115                 120                 125             


Asp Gly Glu Ile Leu Leu Lys Gln Ala Lys Arg Gly Thr Pro Arg Thr 
    130                 135                 140                 


Leu Lys Trp Thr Arg Asn Thr Thr Asn Cys Pro Leu Trp Val Thr Ser 
145                 150                 155                 160 


Cys Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
                165                 170                 175     


Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
            180                 185                 190         


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
        195                 200                 205             


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr 
    210                 215                 220                 


Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
225                 230                 235                 240 


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly 
                245                 250                 255     


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys 
            260                 265                 270         


Ile 
    


<210> 14
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210> 15
<211> 2193
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 15
atggagactg ataccctgct cctctgggtg ctgcttctct gggtccctgg ctcaaccggc       60

gaagcccaca agtccgagat cgcccatcgc tataatgctc ttggagaaca gcatttcaag      120

ggactggtgc tgattgcctt ctcccagtac ctccaaaagg ccagctatga tgagcacgcc      180

aagctcgtcc aagaagtcac cgactttgct aagacttgtg tggccgacga aagcgctgcc      240

aattgcgata agtcactcca tactctcttc ggggacaagc tgtgcgctat tcccaacctc      300

cgcgagaatt acggtgagct ggccgactgt tgcaccaaac aggagccaga gcggaacgag      360

tgcttccttc aacacaaaga tgacaatcct tcactgcctc ctttcgaacg gcccgaggca      420

gaggcaatgt gcactagctt caaggagaac ccaaccacct tcatgggaca ctacctccat      480

gaggtcgcta gacggcatcc ctacttctat gccccagagc ttctgtatta tgcagaacag      540

tacaatgaga tcctgaccca gtgctgtgct gaggctgata aggagagctg cctgacccca      600

aagctcgacg gagtgaagga aaaggctctt gtgtccagcg tgcggcagcg catgaagtgc      660

tcttcaatgc agaagtttgg ggagcgcgcc ttcaaagcct gggccgtggc cagactgtcc      720

cagacctttc ctaatgctga ctttgccgag atcaccaagc tcgctactga cctgaccaag      780

gtcaacaaag agtgttgcca cggagatctg ctcgaatgcg ccgacgaccg cgctgagctt      840

gctaagtaca tgtgcgaaaa ccaggcaacc atttctagca agctgcagac ctgttgtgat      900

aagcctctgc tgaagaaagc ccattgcctc agcgaggtcg aacatgacac tatgccggca      960

gacctccccg ctatcgccgc tgacttcgtg gaggaccaag aagtgtgcaa gaattacgcc     1020

gaggctaagg acgtgttcct tggtactttc ctctacgagt atagccggag gcaccctgac     1080

tacagcgtgt ctcttctgct tcggctcgcc aagaagtacg aagccaccct cgaaaaatgc     1140

tgcgccgaag caaatccgcc agcttgttac gggactgtgc tggctgagtt tcagcccctg     1200

gtggaagagc ccaagaacct cgtcaagacc aactgcgacc tttacgagaa actgggtgaa     1260

tacgggtttc agaatgccat tctggtgcgg tacacccaga aggcaccaca agtgtccacc     1320

ccaacccttg tcgaggcagc ccgcaacctt ggacgcgtcg ggaccaagtg ttgtaccctg     1380

cccgaggacc aacgcctgcc ctgcgtcgag gactacctta gcgccattct gaacagagtc     1440

tgtctgctcc atgaaaagac ccctgtgtct gagcacgtga ccaagtgctg ttcaggctca     1500

ctggtggaga ggaggccttg cttttctgcc ctgaccgtgg acgaaaccta cgtgcccaag     1560

gagttcaaag ctgaaacctt cactttccat tcagacatct gtaccctccc cgaaaaggaa     1620

aagcaaatca agaagcagac cgcccttgct gaactggtga agcacaagcc aaaggccacc     1680

gccgaacaac tcaagactgt gatggacgac ttcgctcagt tcctcgacac ttgctgcaaa     1740

gccgccgaca aagatacctg tttctcaacc gaggggccga acctggtgac tagagccaag     1800

gacgccctgg ccggaggagg tggttctggc ggtggtggtt ccggcggagg aggatctgcc     1860

aggaatggag atcactgccc actcggaccg ggacggtgtt gtcgcctgca cactgtgcgc     1920

gcatctcttg aggatctggg atgggctgat tgggtgctct ctcccagaga ggtgcaagtc     1980

accatgtgca ttggcgcctg cccctcccaa ttcagggcag ctaacatgca tgctcagatc     2040

aagactagcc tgcacaggct gaagcccgac actgtccctg ccccatgttg tgtgccggcc     2100

tcctataacc caatggtcct gatccaaaag accgataccg gagtgtcact tcagacttac     2160

gacgatctgc ttgcaaaaga ctgccattgc atc                                  2193


<210> 16
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Ala Leu Gly Glu 
1               5                   10                  15      


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Lys Ala Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         


Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             


Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 


Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     


Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         


Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro 
    210                 215                 220                 


Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 
            260                 265                 270         


Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His 
        275                 280                 285             


Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala 
    290                 295                 300                 


Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 
            340                 345                 350         


Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala 
        355                 360                 365             


Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu 
385                 390                 395                 400 


Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 
            420                 425                 430         


Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys 
        435                 440                 445             


Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser 
465                 470                 475                 480 


Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 
            500                 505                 510         


Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu 
    530                 535                 540                 


Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys 
545                 550                 555                 560 


Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val 
                565                 570                 575     


Thr Arg Ala Lys Asp Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser Ala Arg Asn Gly Asp His Cys Pro Leu 
        595                 600                 605             


Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu 
    610                 615                 620                 


Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val 
625                 630                 635                 640 


Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met 
                645                 650                 655     


His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val 
            660                 665                 670         


Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile 
        675                 680                 685             


Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu 
    690                 695                 700                 


Ala Lys Asp Cys His Cys Ile 
705                 710     


<210> 17
<211> 2151
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 17
atggagactg atacccttct gctctgggtg cttctgctgt gggtgccagg atccaccggc       60

gaagcccata agtcggaaat cgcacatcgg tacaacgcgc tcggggaaca gcacttcaaa      120

ggccttgtcc tgatcgcgtt ctcccaatac cttcaaaagg cctcgtacga tgaacatgct      180

aagctcgtcc aagaggtgac cgacttcgca aagacttgtg tggccgatga gtcggcagcc      240

aactgcgaca agagcctcca cactctcttc ggagacaagc tgtgcgcaat tcctaatctg      300

cgcgagaatt acggggaact ggcggactgc tgtactaagc aagagccgga acgcaatgag      360

tgcttcctcc agcataagga cgacaaccct tccctccctc ccttcgaacg cccagaggcc      420

gaagcgatgt gtacctcctt caaggaaaac ccgaccacgt ttatgggaca ttacctccac      480

gaagtcgcca gacggcatcc ctacttctac gcgcctgagc tgctctatta cgccgaacag      540

tacaacgaga tcctgacgca gtgttgcgct gaggcagaca aggagagctg cttgaccccg      600

aaactcgatg gagtgaagga gaaggccctg gtgagcagcg tgcgccagcg gatgaagtgc      660

tcatcgatgc agaagttcgg cgagagagct ttcaaggcgt gggccgtggc caggctgtca      720

cagacctttc caaacgcgga tttcgcagag atcaccaagc tggccactga cctcactaaa      780

gtcaacaagg aatgctgcca cggagatctc ttggaatgtg ccgatgacag ggccgaattg      840

gctaagtaca tgtgcgaaaa tcaagctacc attagctcga agctgcagac gtgctgcgat      900

aagccgctgc tgaagaaggc tcattgcctg tccgaggtgg agcacgacac catgccagcc      960

gacctcccgg ccatcgcagc agattttgtg gaggatcagg aagtgtgcaa gaattacgca     1020

gaagctaagg atgtgtttct tgggactttt ctctacgagt acagccggag acacccggac     1080

tatagcgtgt ccctgctgct gcgcttggct aagaaatacg aagctaccct tgaaaaatgc     1140

tgcgcagagg ccaaccctcc ggcttgctac ggaactgtgc tggctgagtt ccagccgctc     1200

gtcgaagaac cgaagaatct cgtgaaaacg aactgcgatc tgtacgagaa attgggagag     1260

tatggatttc aaaatgccat tctggtccgc tacactcaga aagctccaca agtctccacg     1320

ccgaccctgg tcgaagcggc gaggaacctt ggacgcgtgg gaaccaagtg ctgtaccctg     1380

ccggaggacc agcgccttcc gtgcgtcgag gattacttgt cagcgatcct caaccgcgtg     1440

tgcttgcttc atgaaaagac tcccgtgtcg gaacacgtga cgaagtgctg ctccggttcg     1500

ctggtggaaa gacgcccgtg cttctcggcc ctgactgtgg acgaaaccta cgtcccaaaa     1560

gagttcaagg ctgaaacctt cactttccac tcggacatct gcactctccc cgaaaaggaa     1620

aaacagatca agaagcagac tgccctggca gagctggtga aacacaagcc caaggcgacg     1680

gccgaacagc tgaaaaccgt gatggacgac tttgcccaat tcctcgacac ttgttgtaaa     1740

gcagccgata aggacacttg cttctccact gagggcccta acctggtcac ccgggctaag     1800

gacgcgctcg cgggaggagg tggcagcgga ggaggcggta gcggaggcgg agggtcatgt     1860

cggctgcaca ccgtgcgggc atcgcttgaa gatttgggat gggccgactg ggtgctgtca     1920

ccgcgggaag tgcaagtgac catgtgcatc ggcgcctgcc cgtcgcagtt tagagcagcg     1980

aatatgcacg cgcaaatcaa gacttcgctg cacagactga agccggatac tgtccctgca     2040

ccatgctgcg tccctgcctc atacaaccca atggtgctga tccagaaaac cgacaccgga     2100

gtgtcgctcc agacttacga cgaccttctg gccaaggact gtcattgtat c              2151


<210> 18
<211> 697
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Ala Leu Gly Glu 
1               5                   10                  15      


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Lys Ala Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         


Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             


Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 


Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     


Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         


Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro 
    210                 215                 220                 


Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 
            260                 265                 270         


Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His 
        275                 280                 285             


Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala 
    290                 295                 300                 


Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 
            340                 345                 350         


Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala 
        355                 360                 365             


Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu 
385                 390                 395                 400 


Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 
            420                 425                 430         


Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys 
        435                 440                 445             


Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser 
465                 470                 475                 480 


Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 
            500                 505                 510         


Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu 
    530                 535                 540                 


Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys 
545                 550                 555                 560 


Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val 
                565                 570                 575     


Thr Arg Ala Lys Asp Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser Cys Arg Leu His Thr Val Arg Ala Ser 
        595                 600                 605             


Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val 
    610                 615                 620                 


Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala 
625                 630                 635                 640 


Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp 
                645                 650                 655     


Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val 
            660                 665                 670         


Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp 
        675                 680                 685             


Leu Leu Ala Lys Asp Cys His Cys Ile 
    690                 695         


<210> 19
<211> 2154
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 19
atggaaactg acactttgct gctttgggtt ctgctccttt gggtccctgg atcaactggt       60

gatgctcaca agtccgaagt ggcccaccgt ttcaaggatc tgggtgagga aaacttcaag      120

gctctcgtcc tgatcgcatt tgcgcagtac ctccagcagt cgccattcga ggaccatgtg      180

aaactcgtca acgaagtgac cgagtttgct aagacttgcg tcgctgacga gtcagcagag      240

aattgtgaca aatccctgca caccctgttc ggcgataagc tctgcactgt ggccaccctc      300

cgggaaactt acggcgagat ggcggattgt tgcgcgaaac aggaacccga gcgcaatgag      360

tgtttcctgc agcacaagga cgacaacccg aacctcccac ggctggtgag gccggaagtg      420

gacgtcatgt gcaccgcatt tcatgacaac gaagagactt tcctgaagaa gtacctgtac      480

gaaatcgctc ggagacatcc gtacttctac gcgccggaac tcctcttctt tgctaagcgg      540

tacaaggcag cctttactga atgctgccag gccgccgaca aagcggcgtg tctgctgccg      600

aaactggacg agctgagaga tgaaggaaag gctagctcgg ccaagcagcg gttgaaatgc      660

gcatcgctcc aaaagttcgg agaaagagct ttcaaggcct gggcagtggc gcggctctcg      720

cagcgcttcc ctaaggcaga gttcgccgag gtcagcaagt tggtgacgga cctgactaaa      780

gtccataccg aatgttgcca cggagatctg ctcgaatgcg ccgatgaccg ggccgacctg      840

gcgaagtaca tttgtgagaa ccaagattca atttcgagca agttgaagga gtgctgcgaa      900

aagccgttgc ttgagaagtc gcactgcatc gcagaagtcg aaaacgatga gatgcctgcc      960

gacttgccga gcctggccgc cgatttcgtg gagagcaaag acgtgtgcaa aaattacgcc     1020

gaggccaagg acgtgttcct gggaatgttc ctgtacgaat atgcgcgacg ccacccagac     1080

tacagcgtgg tcctgctgct ccgccttgct aaaacttacg aaaccacgct ggagaaatgc     1140

tgtgccgcag ccgacccaca tgagtgctac gcaaaggtgt tcgacgagtt taaacccctt     1200

gtggaagaac cgcagaatct gatcaagcag aactgcgagc tgttcgaaca actcggagaa     1260

tacaagttcc agaacgctct gcttgtcaga tacaccaaga aagtgccgca agtgtccacg     1320

ccaaccctgg tggaagtctc acgcaacctg ggaaaggtcg gaagcaagtg ctgtaagcat     1380

cctgaagcaa agagaatgcc atgcgcggag gactacctgt ccgttgtcct gaatcaactc     1440

tgcgtgctgc acgagaaaac tccagtgtcg gaccgcgtca ccaagtgttg cacggaatcg     1500

ctcgtgaatc gcaggccgtg cttctccgcc ctggaagttg atgagactta cgtcccgaaa     1560

gagtttcagg ccgaaacctt cacctttcac gcggacatct gcactctctc tgaaaaggaa     1620

agacaaatca agaagcagac tgccctggtg gagctggtca agcataaacc aaaggcgacc     1680

aaggaacagt tgaaagccgt gatggacgat ttcgctgcct tcgtggagaa gtgctgcaag     1740

gccgacgaca aggaaacttg ctttgccgag gaaggaaaga aactggtggc cgcatcccaa     1800

gccgcgctgg gactcggagg tggtgggtcg gggggagggg gctccggcgg cggagggtca     1860

tgtcgcctcc acaccgtgcg ggcgtccctg gaagatctgg gatgggccga ttgggtgctg     1920

tccccgcgcg aggtgcaagt gactatgtgt atcggcgcgt gcccatcaca attcagggca     1980

gccaatatgc atgcacagat caaaacctcg ctccaccgcc ttaagccgga caccgtgccc     2040

gcgccctgct gcgtgcctgc ttcctataac cctatggttc tgatccaaaa gaccgatacc     2100

ggcgtgagcc tgcagaccta cgatgatctc ctggccaagg actgccactg tatc           2154


<210> 20
<211> 698
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Gly Ser Cys Arg Leu His Thr Val Arg Ala 
        595                 600                 605             


Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu 
    610                 615                 620                 


Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala 
625                 630                 635                 640 


Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro 
                645                 650                 655     


Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met 
            660                 665                 670         


Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp 
        675                 680                 685             


Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    690                 695             


<210> 21
<211> 2193
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 21
atggagactg atacccttct gctctgggtg cttctgctgt gggtgccagg atccaccggc       60

gaagcccata agtcggaaat cgcacatcgg tacaacgcgc tcggggaaca gcacttcaaa      120

ggccttgtcc tgatcgcgtt ctcccaatac cttcaaaagg cctcgtacga tgaacatgct      180

aagctcgtcc aagaggtgac cgacttcgca aagacttgtg tggccgatga gtcggcagcc      240

aactgcgaca agagcctcca cactctcttc ggagacaagc tgtgcgcaat tcctaatctg      300

cgcgagaatt acggggaact ggcggactgc tgtactaagc aagagccgga acgcaatgag      360

tgcttcctcc agcataagga cgacaaccct tccctccctc ccttcgaacg cccagaggcc      420

gaagcgatgt gtacctcctt caaggaaaac ccgaccacgt ttatgggaca ttacctccac      480

gaagtcgcca gacggcatcc ctacttctac gcgcctgagc tgctctatta cgccgaacag      540

tacaacgaga tcctgacgca gtgttgcgct gaggcagaca aggagagctg cttgaccccg      600

aaactcgatg gagtgaagga gaaggccctg gtgagcagcg tgcgccagcg gatgaagtgc      660

tcatcgatgc agaagttcgg cgagagagct ttcaaggcgt gggccgtggc caggctgtca      720

cagacctttc caaacgcgga tttcgcagag atcaccaagc tggccactga cctcactaaa      780

gtcaacaagg aatgctgcca cggagatctc ttggaatgtg ccgatgacag ggccgaattg      840

gctaagtaca tgtgcgaaaa tcaagctacc attagctcga agctgcagac gtgctgcgat      900

aagccgctgc tgaagaaggc tcattgcctg tccgaggtgg agcacgacac catgccagcc      960

gacctcccgg ccatcgcagc agattttgtg gaggatcagg aagtgtgcaa gaattacgca     1020

gaagctaagg atgtgtttct tgggactttt ctctacgagt acagccggag acacccggac     1080

tatagcgtgt ccctgctgct gcgcttggct aagaaatacg aagctaccct tgaaaaatgc     1140

tgcgcagagg ccaaccctcc ggcttgctac ggaactgtgc tggctgagtt ccagccgctc     1200

gtcgaagaac cgaagaatct cgtgaaaacg aactgcgatc tgtacgagaa attgggagag     1260

tatggatttc aaaatgccat tctggtccgc tacactcaga aagctccaca agtctccacg     1320

ccgaccctgg tcgaagcggc gaggaacctt ggacgcgtgg gaaccaagtg ctgtaccctg     1380

ccggaggacc agcgccttcc gtgcgtcgag gattacttgt cagcgatcct caaccgcgtg     1440

tgcttgcttc atgaaaagac tcccgtgtcg gaacacgtga cgaagtgctg ctccggttcg     1500

ctggtggaaa gacgcccgtg cttctcggcc ctgactgtgg acgaaaccta cgtcccaaaa     1560

gagttcaagg ctgaaacctt cactttccac tcggacatct gcactctccc cgaaaaggaa     1620

aaacagatca agaagcagac tgccctggca gagctggtga aacacaagcc caaggcgacg     1680

gccgaacagc tgaaaaccgt gatggacgac tttgcccaat tcctcgacac ttgttgtaaa     1740

gcagccgata aggacacttg cttctccact gagggcccta acctggtcac ccgggctaag     1800

gacgcgctcg cgggaggagg tggcagcgga ggaggcggta gcggaggcgg agggagcgct     1860

agaaacggcg accacagccc gttggggcca ggtagatcat gtcggctgca caccgtgcgg     1920

gcatcgcttg aagatttggg atgggccgac tgggtgctgt caccgcggga agtgcaagtg     1980

accatgtgca tcggcgcctg cccgtcgcag tttagagcag cgaatatgca cgcgcaaatc     2040

aagacttcgc tgcacagact gaagccggat actgtccctg caccatgctg cgtccctgcc     2100

tcatacaacc caatggtgct gatccagaaa accgacaccg gagtgtcgct ccagacttac     2160

gacgaccttc tggccaagga ctgtcattgt atc                                  2193


<210> 22
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Ala Leu Gly Glu 
1               5                   10                  15      


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Lys Ala Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         


Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             


Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 


Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     


Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         


Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro 
    210                 215                 220                 


Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 
            260                 265                 270         


Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His 
        275                 280                 285             


Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala 
    290                 295                 300                 


Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 
            340                 345                 350         


Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala 
        355                 360                 365             


Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu 
385                 390                 395                 400 


Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 
            420                 425                 430         


Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys 
        435                 440                 445             


Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser 
465                 470                 475                 480 


Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 
            500                 505                 510         


Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu 
    530                 535                 540                 


Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys 
545                 550                 555                 560 


Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val 
                565                 570                 575     


Thr Arg Ala Lys Asp Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser Ala Arg Asn Gly Asp His Ser Pro Leu 
        595                 600                 605             


Gly Pro Gly Arg Ser Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu 
    610                 615                 620                 


Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val 
625                 630                 635                 640 


Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met 
                645                 650                 655     


His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val 
            660                 665                 670         


Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile 
        675                 680                 685             


Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu 
    690                 695                 700                 


Ala Lys Asp Cys His Cys Ile 
705                 710     


<210> 23
<211> 2193
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 23
atggagactg atacccttct gctctgggtg cttctgctgt gggtgccagg atccaccggc       60

gaagcccata agtcggaaat cgcacatcgg tacaacgcgc tcggggaaca gcacttcaaa      120

ggccttgtcc tgatcgcgtt ctcccaatac cttcaaaagg cctcgtacga tgaacatgct      180

aagctcgtcc aagaggtgac cgacttcgca aagacttgtg tggccgatga gtcggcagcc      240

aactgcgaca agagcctcca cactctcttc ggagacaagc tgtgcgcaat tcctaatctg      300

cgcgagaatt acggggaact ggcggactgc tgtactaagc aagagccgga acgcaatgag      360

tgcttcctcc agcataagga cgacaaccct tccctccctc ccttcgaacg cccagaggcc      420

gaagcgatgt gtacctcctt caaggaaaac ccgaccacgt ttatgggaca ttacctccac      480

gaagtcgcca gacggcatcc ctacttctac gcgcctgagc tgctctatta cgccgaacag      540

tacaacgaga tcctgacgca gtgttgcgct gaggcagaca aggagagctg cttgaccccg      600

aaactcgatg gagtgaagga gaaggccctg gtgagcagcg tgcgccagcg gatgaagtgc      660

tcatcgatgc agaagttcgg cgagagagct ttcaaggcgt gggccgtggc caggctgtca      720

cagacctttc caaacgcgga tttcgcagag atcaccaagc tggccactga cctcactaaa      780

gtcaacaagg aatgctgcca cggagatctc ttggaatgtg ccgatgacag ggccgaattg      840

gctaagtaca tgtgcgaaaa tcaagctacc attagctcga agctgcagac gtgctgcgat      900

aagccgctgc tgaagaaggc tcattgcctg tccgaggtgg agcacgacac catgccagcc      960

gacctcccgg ccatcgcagc agattttgtg gaggatcagg aagtgtgcaa gaattacgca     1020

gaagctaagg atgtgtttct tgggactttt ctctacgagt acagccggag acacccggac     1080

tatagcgtgt ccctgctgct gcgcttggct aagaaatacg aagctaccct tgaaaaatgc     1140

tgcgcagagg ccaaccctcc ggcttgctac ggaactgtgc tggctgagtt ccagccgctc     1200

gtcgaagaac cgaagaatct cgtgaaaacg aactgcgatc tgtacgagaa attgggagag     1260

tatggatttc aaaatgccat tctggtccgc tacactcaga aagctccaca agtctccacg     1320

ccgaccctgg tcgaagcggc gaggaacctt ggacgcgtgg gaaccaagtg ctgtaccctg     1380

ccggaggacc agcgccttcc gtgcgtcgag gattacttgt cagcgatcct caaccgcgtg     1440

tgcttgcttc atgaaaagac tcccgtgtcg gaacacgtga cgaagtgctg ctccggttcg     1500

ctggtggaaa gacgcccgtg cttctcggcc ctgactgtgg acgaaaccta cgtcccaaaa     1560

gagttcaagg ctgaaacctt cactttccac tcggacatct gcactctccc cgaaaaggaa     1620

aaacagatca agaagcagac tgccctggca gagctggtga aacacaagcc caaggcgacg     1680

gccgaacagc tgaaaaccgt gatggacgac tttgcccaat tcctcgacac ttgttgtaaa     1740

gcagccgata aggacacttg cttctccact gagggcccta acctggtcac ccgggctaag     1800

gacgcgctcg cgggaggagg tggcagcgga ggaggcggta gcggaggcgg agggagcgct     1860

agaaacggcg accactgtcc actggggcca ggtcggtgct gtcggctgca caccgtgcgg     1920

gcatcgcttg aagatttggg atgggccgac tgggtgctgt caccgcggga agtgcaagtg     1980

accatgtgca tcggcgcctg cccgtcgcag tttagagcag cgaatatgca cgcgcaaatc     2040

aagacttcgc tgcacagact gaagccggat actgtccctg caccatcatg cgtccctgcc     2100

tcatacaacc caatggtgct gatccagaaa accgacaccg gagtgtcgct ccagacttac     2160

gacgaccttc tggccaagga ctgtcattgt atc                                  2193


<210> 24
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Ala Leu Gly Glu 
1               5                   10                  15      


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Lys Ala Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         


Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             


Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 


Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     


Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         


Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro 
    210                 215                 220                 


Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 
            260                 265                 270         


Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His 
        275                 280                 285             


Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala 
    290                 295                 300                 


Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 
            340                 345                 350         


Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala 
        355                 360                 365             


Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu 
385                 390                 395                 400 


Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 
            420                 425                 430         


Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys 
        435                 440                 445             


Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser 
465                 470                 475                 480 


Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 
            500                 505                 510         


Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu 
    530                 535                 540                 


Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys 
545                 550                 555                 560 


Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val 
                565                 570                 575     


Thr Arg Ala Lys Asp Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser Ala Arg Asn Gly Asp His Cys Pro Leu 
        595                 600                 605             


Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu 
    610                 615                 620                 


Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val 
625                 630                 635                 640 


Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met 
                645                 650                 655     


His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val 
            660                 665                 670         


Pro Ala Pro Ser Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile 
        675                 680                 685             


Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu 
    690                 695                 700                 


Ala Lys Asp Cys His Cys Ile 
705                 710     


<210> 25
<211> 2196
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 25
atggaaaccg atactctgct gctgtgggtg cttcttcttt gggtgccggg atcaaccggc       60

gatgcccaca agtcggaggt ggcccatcgg tttaaggacc tcggggagga gaacttcaaa      120

gccctggtcc tcatcgcctt cgcccaatac ctccagcagt gtccattcga agatcacgtg      180

aagctcgtga acgaagtgac tgaatttgcc aagacttgtg tcgcagacga aagcgccgaa      240

aactgcgaca agtcgttgca tactctcttc ggggataagc tgtgcactgt cgcaaccctt      300

agagagactt acggtgaaat ggctgattgc tgcgccaaac aagagccgga gcgcaacgag      360

tgcttcctcc aacataagga cgacaacccc aacctcccac gcctggtgcg gcctgaggtc      420

gacgtcatgt gcaccgcttt ccatgacaat gaggagactt ttctcaagaa gtatctgtac      480

gagatcgccc ggaggcaccc atacttttat gcaccggagc tccttttctt cgctaagcgg      540

tacaaggcgg cgttcactga atgctgtcag gcagcagaca aggcagcatg cctcctgccg      600

aaactggacg aacttcgcga cgagggtaaa gcgtcgtccg ccaagcagcg ccttaagtgc      660

gcctcgttgc agaagtttgg tgaacgcgca ttcaaagcgt gggccgtcgc aagactttcg      720

cagcggttcc caaaagcgga gtttgccgag gtgtccaaac tggtcaccga cctgaccaag      780

gtccacaccg agtgctgcca cggcgatctg ctcgaatgcg ccgacgaccg ggctgatctc      840

gcaaagtaca tttgcgagaa ccaagactcg atctcgtcaa aactgaagga atgctgcgag      900

aagccgctgt tggaaaagag ccattgtatc gccgaagtgg agaacgatga aatgcctgct      960

gatctgccaa gcctcgccgc agactttgtg gagagcaaag acgtgtgcaa gaactacgcc     1020

gaagcgaagg acgtgtttct cgggatgttc ctctacgagt acgcgcgcag gcaccctgac     1080

tactcagtgg tcctgctgtt gcggctggcc aaaacttacg aaaccaccct cgaaaagtgc     1140

tgcgcggctg ccgatccaca tgaatgctac gcaaaggtgt tcgatgaatt taagcctctg     1200

gtggaggaac cacagaacct gatcaagcaa aattgtgaac tgtttgaaca gctgggagag     1260

tacaaatttc agaatgccct gctggtcaga tacactaaga aggtgcccca agtctccact     1320

ccaaccctcg tggaggtgtc acggaatctc ggcaaagtgg gcagcaaatg ctgtaagcac     1380

ccggaagcaa agaggatgcc ctgcgctgaa gattacctgt ccgtggtgct gaatcagctt     1440

tgtgtgctgc acgaaaagac gcctgtctcc gaccgggtga ccaagtgctg taccgaatcg     1500

ctcgtgaatc gcagaccctg cttctccgct ctcgaagtgg acgaaactta cgtcccgaag     1560

gagttcaatg cggaaacctt caccttccac gcggacatct gtaccctgag cgaaaaagag     1620

cggcagatca agaaacagac tgccctggtg gaactggtga agcacaagcc gaaggcaacg     1680

aaggagcagc tgaaggcggt gatggatgac tttgcagcct tcgtggaaaa gtgttgcaag     1740

gcagatgata aagaaacctg tttcgcggaa gaggggaaga agttggtggc tgccagccag     1800

gccgctctcg gactgggagg tggaggatca ggaggcggag gctccggagg aggaggctcg     1860

gctcgcaatg gcgatcattg cccgctcgga ccgggacgct gctgcagact gcataccgtc     1920

cgcgcttcct tggaagatct gggatgggcg gattgggtgt tgtcaccaag agaggtgcaa     1980

gtgacgatgt gtatcggtgc gtgcccttca cagttccgcg ctgcgaacat gcatgcccaa     2040

atcaagacca gcctgcaccg gctgaagccg gacactgtcc cagctccatg ttgcgtgccc     2100

gcatcgtaca acccgatggt gctcatccag aaaactgaca ctggagtctc actgcaaacg     2160

tacgacgatt tgctcgccaa agattgccac tgcatt                               2196


<210> 26
<211> 712
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Gly Ser Ala Arg Asn Gly Asp His Cys Pro 
        595                 600                 605             


Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu 
    610                 615                 620                 


Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln 
625                 630                 635                 640 


Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn 
                645                 650                 655     


Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr 
            660                 665                 670         


Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu 
        675                 680                 685             


Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu 
    690                 695                 700                 


Leu Ala Lys Asp Cys His Cys Ile 
705                 710         


<210> 27
<211> 2169
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 27
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgatgctc ataaatcaga agtggcgcac agattcaagg acctcggaga agaaaacttt      120

aaagcactgg tgctgatcgc cttcgcacaa tacttgcagc agtgcccgtt cgaagatcac      180

gtgaaactgg tcaacgaagt gaccgagttc gctaagacct gtgtcgctga cgagagcgcg      240

gaaaactgcg acaagtccct tcacacgctg ttcggcgata agctctgcac ggtcgcgact      300

ctgagggaaa cctacggaga gatggcagat tgctgtgcaa agcaggaacc tgagaggaac      360

gaatgtttcc tgcaacataa ggacgacaac ccaaatcttc cgcgcctcgt gcgtccggag      420

gtggacgtga tgtgcacggc cttccatgat aatgaggaaa ctttcctgaa aaagtacctc      480

tacgaaatcg cccggagaca cccgtatttc tacgccccgg agcttctgtt cttcgcaaag      540

cgctacaagg cggcttttac tgagtgctgc caagctgccg acaaagccgc atgcctgctg      600

ccaaagctcg atgaactcag ggacgaggga aaggcatcct ccgcaaagca gcgcctgaaa      660

tgcgcctcac tgcaaaagtt tggagaacgc gcattcaagg cctgggcggt ggcccggctc      720

agccagagat tccccaaggc cgagtttgcc gaggtgtcca agctcgttac tgatctgacc      780

aaagtccaca ccgaatgctg tcatggagat cttttggagt gcgccgacga cagagcggac      840

ctggccaagt acatctgcga aaaccaggat tcgatctcat ctaagctcaa ggagtgctgc      900

gaaaaacccc tgttggaaaa gtcgcactgt attgcggaag tggagaacga cgagatgcct      960

gcagacttgc cgtcactggc ggctgacttc gtggagtcga aggacgtgtg caaaaactac     1020

gcggaagcga aggatgtctt tctgggaatg ttcctgtacg aatacgcacg gcgccatccg     1080

gactactcag ttgtgctgtt gctccgcctt gctaagactt acgaaactac cttggagaaa     1140

tgctgcgccg ccgccgatcc tcacgaatgt tacgcaaaag tgttcgacga gtttaagcct     1200

ctcgtggaag aacctcagaa tctgatcaag cagaactgtg aactgttcga gcagctcggg     1260

gaatacaagt tccagaatgc gctgctcgtc cggtatacta agaaagtgcc acaagtgtcc     1320

accccgactc tggtcgaagt gtcgcgcaat ctggggaaag tcggatcgaa gtgctgcaag     1380

catccggagg cgaaacgaat gccgtgcgcg gaggattacc tgtcggtggt gctgaaccag     1440

ctctgcgtgc tgcatgaaaa gaccccggtg tccgaccggg tcaccaagtg ttgcactgag     1500

tccctcgtga accggcgccc ttgcttctcg gccctcgaag tcgatgagac ttacgtgcca     1560

aaagagttta atgccgaaac cttcaccttt cacgctgaca tctgcacttt gagcgaaaag     1620

gaaagacaga ttaagaagca gacggccctg gtggaactcg tcaaacataa acccaaagct     1680

acgaaagagc agctgaaagc agttatggac gatttcgccg ctttcgtgga aaaatgctgc     1740

aaggccgacg ataaggaaac ttgtttcgcc gaggagggga agaagctggt cgcagcaagc     1800

caagccgctc tgggtcttgg cggtggaggc agcgcgagga atggcgacca ctgcccattg     1860

ggaccgggac ggtgttgcag actccacact gtccgggctt cactcgagga cctgggttgg     1920

gccgactggg tgctgtcgcc ccgggaagtc caggtcacca tgtgcatcgg agcgtgcccg     1980

agccaatttc gcgccgcgaa catgcacgcc cagatcaaga cctcgctgca ccgcctgaag     2040

cctgacaccg tgccagcccc ctgctgtgtg ccggcctcct acaacccaat ggtgctcatc     2100

caaaagaccg ataccggcgt gagcctgcaa acttacgatg atcttctggc caaggactgt     2160

cactgcatc                                                             2169


<210> 28
<211> 702
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 28
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Ala Arg 
            580                 585                 590         


Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His 
        595                 600                 605             


Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu 
    610                 615                 620                 


Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser 
625                 630                 635                 640 


Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His 
                645                 650                 655     


Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser 
            660                 665                 670         


Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu 
        675                 680                 685             


Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    690                 695                 700         


<210> 29
<211> 2169
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 29
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgatgctc ataaatcaga agtggcgcac agattcaagg acctcggaga agaaaacttt      120

aaagcactgg tgctgatcgc cttcgcacaa tacttgcagc agtgcccgtt cgaagatcac      180

gtgaaactgg tcaacgaagt gaccgagttc gctaagacct gtgtcgctga cgagagcgcg      240

gaaaactgcg acaagtccct tcacacgctg ttcggcgata agctctgcac ggtcgcgact      300

ctgagggaaa cctacggaga gatggcagat tgctgtgcaa agcaggaacc tgagaggaac      360

gaatgtttcc tgcaacataa ggacgacaac ccaaatcttc cgcgcctcgt gcgtccggag      420

gtggacgtga tgtgcacggc cttccatgat aatgaggaaa ctttcctgaa aaagtacctc      480

tacgaaatcg cccggagaca cccgtatttc tacgccccgg agcttctgtt cttcgcaaag      540

cgctacaagg cggcttttac tgagtgctgc caagctgccg acaaagccgc atgcctgctg      600

ccaaagctcg atgaactcag ggacgaggga aaggcatcct ccgcaaagca gcgcctgaaa      660

tgcgcctcac tgcaaaagtt tggagaacgc gcattcaagg cctgggcggt ggcccggctc      720

agccagagat tccccaaggc cgagtttgcc gaggtgtcca agctcgttac tgatctgacc      780

aaagtccaca ccgaatgctg tcatggagat cttttggagt gcgccgacga cagagcggac      840

ctggccaagt acatctgcga aaaccaggat tcgatctcat ctaagctcaa ggagtgctgc      900

gaaaaacccc tgttggaaaa gtcgcactgt attgcggaag tggagaacga cgagatgcct      960

gcagacttgc cgtcactggc ggctgacttc gtggagtcga aggacgtgtg caaaaactac     1020

gcggaagcga aggatgtctt tctgggaatg ttcctgtacg aatacgcacg gcgccatccg     1080

gactactcag ttgtgctgtt gctccgcctt gctaagactt acgaaactac cttggagaaa     1140

tgctgcgccg ccgccgatcc tcacgaatgt tacgcaaaag tgttcgacga gtttaagcct     1200

ctcgtggaag aacctcagaa tctgatcaag cagaactgtg aactgttcga gcagctcggg     1260

gaatacaagt tccagaatgc gctgctcgtc cggtatacta agaaagtgcc acaagtgtcc     1320

accccgactc tggtcgaagt gtcgcgcaat ctggggaaag tcggatcgaa gtgctgcaag     1380

catccggagg cgaaacgaat gccgtgcgcg gaggattacc tgtcggtggt gctgaaccag     1440

ctctgcgtgc tgcatgaaaa gaccccggtg tccgaccggg tcaccaagtg ttgcactgag     1500

tccctcgtga accggcgccc ttgcttctcg gccctcgaag tcgatgagac ttacgtgcca     1560

aaagagttta atgccgaaac cttcaccttt cacgctgaca tctgcacttt gagcgaaaag     1620

gaaagacaga ttaagaagca gacggccctg gtggaactcg tcaaacataa acccaaagct     1680

acgaaagagc agctgaaagc agttatggac gatttcgccg ctttcgtgga aaaatgctgc     1740

aaggccgacg ataaggaaac ttgtttcgcc gaggagggga agaagctggt cgcagcaagc     1800

caagccgctc tgggtcttgg cccaccgggc agcgcgagga atggcgacca ctgcccattg     1860

ggaccgggac ggtgttgcag actccacact gtccgggctt cactcgagga cctgggttgg     1920

gccgactggg tgctgtcgcc ccgggaagtc caggtcacca tgtgcatcgg agcgtgcccg     1980

agccaatttc gcgccgcgaa catgcacgcc cagatcaaga cctcgctgca ccgcctgaag     2040

cctgacaccg tgccagcccc ctgctgtgtg ccggcctcct acaacccaat ggtgctcatc     2100

caaaagaccg ataccggcgt gagcctgcaa acttacgatg atcttctggc caaggactgt     2160

cactgcatc                                                             2169


<210> 30
<211> 702
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Pro Pro Gly Ser Ala Arg 
            580                 585                 590         


Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His 
        595                 600                 605             


Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu 
    610                 615                 620                 


Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser 
625                 630                 635                 640 


Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His 
                645                 650                 655     


Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser 
            660                 665                 670         


Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu 
        675                 680                 685             


Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    690                 695                 700         


<210> 31
<211> 2154
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 31
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgatgctc ataaatcaga agtggcgcac agattcaagg acctcggaga agaaaacttt      120

aaagcactgg tgctgatcgc cttcgcacaa tacttgcagc agtgcccgtt cgaagatcac      180

gtgaaactgg tcaacgaagt gaccgagttc gctaagacct gtgtcgctga cgagagcgcg      240

gaaaactgcg acaagtccct tcacacgctg ttcggcgata agctctgcac ggtcgcgact      300

ctgagggaaa cctacggaga gatggcagat tgctgtgcaa agcaggaacc tgagaggaac      360

gaatgtttcc tgcaacataa ggacgacaac ccaaatcttc cgcgcctcgt gcgtccggag      420

gtggacgtga tgtgcacggc cttccatgat aatgaggaaa ctttcctgaa aaagtacctc      480

tacgaaatcg cccggagaca cccgtatttc tacgccccgg agcttctgtt cttcgcaaag      540

cgctacaagg cggcttttac tgagtgctgc caagctgccg acaaagccgc atgcctgctg      600

ccaaagctcg atgaactcag ggacgaggga aaggcatcct ccgcaaagca gcgcctgaaa      660

tgcgcctcac tgcaaaagtt tggagaacgc gcattcaagg cctgggcggt ggcccggctc      720

agccagagat tccccaaggc cgagtttgcc gaggtgtcca agctcgttac tgatctgacc      780

aaagtccaca ccgaatgctg tcatggagat cttttggagt gcgccgacga cagagcggac      840

ctggccaagt acatctgcga aaaccaggat tcgatctcat ctaagctcaa ggagtgctgc      900

gaaaaacccc tgttggaaaa gtcgcactgt attgcggaag tggagaacga cgagatgcct      960

gcagacttgc cgtcactggc ggctgacttc gtggagtcga aggacgtgtg caaaaactac     1020

gcggaagcga aggatgtctt tctgggaatg ttcctgtacg aatacgcacg gcgccatccg     1080

gactactcag ttgtgctgtt gctccgcctt gctaagactt acgaaactac cttggagaaa     1140

tgctgcgccg ccgccgatcc tcacgaatgt tacgcaaaag tgttcgacga gtttaagcct     1200

ctcgtggaag aacctcagaa tctgatcaag cagaactgtg aactgttcga gcagctcggg     1260

gaatacaagt tccagaatgc gctgctcgtc cggtatacta agaaagtgcc acaagtgtcc     1320

accccgactc tggtcgaagt gtcgcgcaat ctggggaaag tcggatcgaa gtgctgcaag     1380

catccggagg cgaaacgaat gccgtgcgcg gaggattacc tgtcggtggt gctgaaccag     1440

ctctgcgtgc tgcatgaaaa gaccccggtg tccgaccggg tcaccaagtg ttgcactgag     1500

tccctcgtga accggcgccc ttgcttctcg gccctcgaag tcgatgagac ttacgtgcca     1560

aaagagttta atgccgaaac cttcaccttt cacgctgaca tctgcacttt gagcgaaaag     1620

gaaagacaga ttaagaagca gacggccctg gtggaactcg tcaaacataa acccaaagct     1680

acgaaagagc agctgaaagc agttatggac gatttcgccg ctttcgtgga aaaatgctgc     1740

aaggccgacg ataaggaaac ttgtttcgcc gaggagggga agaagctggt cgcagcaagc     1800

caagccgctc tgggtcttgc gaggaatggc gaccactgcc cattgggacc gggacggtgt     1860

tgcagactcc acactgtccg ggcttcactc gaggacctgg gttgggccga ctgggtgctg     1920

tcgccccggg aagtccaggt caccatgtgc atcggagcgt gcccgagcca atttcgcgcc     1980

gcgaacatgc acgcccagat caagacctcg ctgcaccgcc tgaagcctga caccgtgcca     2040

gccccctgct gtgtgccggc ctcctacaac ccaatggtgc tcatccaaaa gaccgatacc     2100

ggcgtgagcc tgcaaactta cgatgatctt ctggccaagg actgtcactg catc           2154


<210> 32
<211> 697
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 32
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Arg Asn Gly Asp His Cys 
            580                 585                 590         


Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser 
        595                 600                 605             


Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val 
    610                 615                 620                 


Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala 
625                 630                 635                 640 


Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp 
                645                 650                 655     


Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val 
            660                 665                 670         


Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp 
        675                 680                 685             


Leu Leu Ala Lys Asp Cys His Cys Ile 
    690                 695         


<210> 33
<211> 1035
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 33
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgaagctc ataagtcaga aatcgcccat agatacaacg acctcgggga acagcacttt      120

aaaggactcg tgttgattgc attcagccag tacctccaaa agtgcagcta cgacgagcat      180

gcgaagctgg tgcaggaagt caccgacttc gccaaaactt gcgtcgctga tgagtcggcg      240

gcaaactgcg acaaatcgct ccacaccctg tttggcgata agctgtgtgc gatcccgaat      300

cttcgagaga attacggaga acttgcagac tgctgcacca agcaggaacc ggaacgcaac      360

gagtgcttcc tccaacacaa ggatgacaac ccatctctgc cccctttcga acggccggag      420

gcggaagcca tgtgcactag ctttaaggag aatccaacta cgttcatggg gcattacctc      480

cacgaggtcg ccaggcggca tccatacttc tacgccccgg aactgctgta ctatgccgag      540

cagtacaacg aaatcctgac gcagtgctgt gccgaggctg ataaggaatc atgcctgacc      600

ccaaagctgg acggagtgaa agaaaaggcg ctcgtgtcgt ccgtgagaca acgcggtgga      660

ggaggctccg gcggcggagg ctcgggaggg ggaggttcag cacggaacgg cgaccactgc      720

cctttggggc cgggacgctg ttgccggctt cacactgtgc gcgcgtccct cgaggatttg      780

ggatgggcag attgggtgct gagcccgaga gaggtccagg tcaccatgtg tatcggtgcc      840

tgcccgagcc agttcagggc tgccaacatg cacgcgcaga tcaaaacttc gctgcatcgc      900

ctgaaaccag acaccgttcc ggcaccctgt tgcgtgcctg cctcctacaa tcctatggtg      960

ctgattcaaa agaccgacac cggagtgtcc ctgcaaactt acgacgatct gctcgccaag     1020

gactgccact gtatc                                                      1035


<210> 34
<211> 324
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu 
1               5                   10                  15      


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         


Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             


Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 


Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     


Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         


Ser Val Arg Gln Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
    210                 215                 220                 


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
225                 230                 235                 240 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
                245                 250                 255     


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
            260                 265                 270         


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
        275                 280                 285             


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
    290                 295                 300                 


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
305                 310                 315                 320 


Cys His Cys Ile 
                


<210> 35
<211> 1122
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 35
atggagacag acacgctcct tttgtgggta ctgctgcttt gggtccctgg gtcgacaggg       60

gataagaccc acacgtgccc tccctgtcca gcacccgagt tgctcggtgg gccatccgtg      120

tttttgtttc ctcccaagcc caaagacacg ttgatgatta gccgcactcc cgaggtaacg      180

tgcgtagtgg tggatgtgtc acatgaggac ccggaggtga agttcaattg gtacgtggac      240

ggagtcgaag tgcacaacgc aaagacgaaa ccccgagagg aacagtacaa ctcgacctat      300

cgcgtagtga gcgtactgac tgtgttgcat caggattggc ttaacggaaa agagtacaag      360

tgtaaagtat ccaataaggc cctcccagcg cctattgaaa agacaatcag caaagcgaag      420

gggcagcctc gcgaaccgca agtatatacc ctcccgccta gccgggacga attgactaag      480

aatcaggtca gcctcacatg tctggtcaaa ggcttttacc cgtcagatat cgcggtcgag      540

tgggagtcca atgggcagcc ggaaaacaat tacaagacaa cgccgccagt cttggactca      600

gacgggtcgt ttttcctcta ctcgaaactg acggtggaca agtcccgatg gcagcaggga      660

aatgtattca gctgttcggt catgcacgag gcgctccaca atcattatac acaaaagtcg      720

ctgtccctgt cgccgggaaa gggaggtggc gggtccggcg gaggaggatc aggtggtgga      780

ggttcagcca gaaacggtga tcattgccca cttggacccg ggaggtgctg tcggcttcac      840

actgtcaggg catcactcga agatctcggg tgggcggact gggtgctttc gcccagagaa      900

gtgcaagtca ctatgtgcat tggtgcgtgc ccgtcgcaat tcagagctgc caacatgcat      960

gcccagatca aaacgagctt gcaccggctg aaacccgaca cagtccccgc tccgtgctgc     1020

gtgccggcgt cgtataaccc catggtcctc atccagaaaa ccgatacggg agtgtcattg     1080

cagacatatg atgacctttt ggccaaggat tgccactgta tc                        1122


<210> 36
<211> 354
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys 
                245                 250                 255     


Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala 
            260                 265                 270         


Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly 
        275                 280                 285             


Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys 
    290                 295                 300                 


Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys 
305                 310                 315                 320 


Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr 
                325                 330                 335     


Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His 
            340                 345                 350         


Cys Ile 
        


<210> 37
<211> 2196
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 37
atggaaaccg atactctgct gctgtgggtg cttcttcttt gggtgccggg atcaaccggc       60

gatgcccaca agtcggaggt ggcccatcgg tttaaggacc tcggggagga gaacttcaaa      120

gccctggtcc tcatcgcctt cgcccaatac ctccagcagt gtccattcga agatcacgtg      180

aagctcgtga acgaagtgac tgaatttgcc aagacttgtg tcgcagacga aagcgccgaa      240

aactgcgaca agtcgttgca tactctcttc ggggataagc tgtgcactgt cgcaaccctt      300

agagagactt acggtgaaat ggctgattgc tgcgccaaac aagagccgga gcgcaacgag      360

tgcttcctcc aacataagga cgacaacccc aacctcccac gcctggtgcg gcctgaggtc      420

gacgtcatgt gcaccgcttt ccatgacaat gaggagactt ttctcaagaa gtatctgtac      480

gagatcgccc ggaggcaccc atacttttat gcaccggagc tccttttctt cgctaagcgg      540

tacaaggcgg cgttcactga atgctgtcag gcagcagaca aggcagcatg cctcctgccg      600

aaactggacg aacttcgcga cgagggtaaa gcgtcgtccg ccaagcagcg ccttaagtgc      660

gcctcgttgc agaagtttgg tgaacgcgca ttcaaagcgt gggccgtcgc aagactttcg      720

cagcggttcc caaaagcgga gtttgccgag gtgtccaaac tggtcaccga cctgaccaag      780

gtccacaccg agtgctgcca cggcgatctg ctcgaatgcg ccgacgaccg ggctgatctc      840

gcaaagtaca tttgcgagaa ccaagactcg atctcgtcaa aactgaagga atgctgcgag      900

aagccgctgt tggaaaagag ccattgtatc gccgaagtgg agaacgatga aatgcctgct      960

gatctgccaa gcctcgccgc agactttgtg gagagcaaag acgtgtgcaa gaactacgcc     1020

gaagcgaagg acgtgtttct cgggatgttc ctctacgagt acgcgcgcag gcaccctgac     1080

tactcagtgg tcctgctgtt gcggctggcc aaaacttacg aaaccaccct cgaaaagtgc     1140

tgcgcggctg ccgatccaca tgaatgctac gcaaaggtgt tcgatgaatt taagcctctg     1200

gtggaggaac cacagaacct gatcaagcaa aattgtgaac tgtttgaaca gctgggagag     1260

tacaaatttc agaatgccct gctggtcaga tacactaaga aggtgcccca agtctccact     1320

ccaaccctcg tggaggtgtc acggaatctc ggcaaagtgg gcagcaaatg ctgtaagcac     1380

ccggaagcaa agaggatgcc ctgcgctgaa gattacctgt ccgtggtgct gaatcagctt     1440

tgtgtgctgc acgaaaagac gcctgtctcc gaccgggtga ccaagtgctg taccgaatcg     1500

ctcgtgaatc gcagaccctg cttctccgct ctcgaagtgg acgaaactta cgtcccgaag     1560

gagttcaatg cggaaacctt caccttccac gcggacatct gtaccctgag cgaaaaagag     1620

cggcagatca agaaacagac tgccctggtg gaactggtga agcacaagcc gaaggcaacg     1680

aaggagcagc tgaaggcggt gatggatgac tttgcagcct tcgtggaaaa gtgttgcaag     1740

gcagatgata aagaaacctg tttcgcggaa gaggggaaga agttggtggc tgccagccag     1800

gccgctctcg gactgggagg tggaggatca ggaggcggag gctccggagg aggaggctcg     1860

gctcacaatg gcgatcattg cccgctcgga ccgggacgct gctgcagact gcataccgtc     1920

cgcgcttcct tggaagatct gggatgggcg gattgggtgt tgtcaccaag agaggtgcaa     1980

gtgacgatgt gtatcggtgc gtgcccttca cagttccgcg ctgcgaacat gcatgcccaa     2040

atcaagacca gcctgcaccg gctgaagccg gacactgtcc cagctccatg ttgcgtgccc     2100

gcatcgtaca acccgatggt gctcatccag aaaactgaca ctggagtctc actgcaaacg     2160

tacgacgatt tgctcgccaa agattgccac tgcatt                               2196


<210> 38
<211> 712
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Gly Ser Ala His Asn Gly Asp His Cys Pro 
        595                 600                 605             


Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu 
    610                 615                 620                 


Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln 
625                 630                 635                 640 


Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn 
                645                 650                 655     


Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr 
            660                 665                 670         


Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu 
        675                 680                 685             


Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu 
    690                 695                 700                 


Leu Ala Lys Asp Cys His Cys Ile 
705                 710         


<210> 39
<211> 2196
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 39
atggaaaccg atactctgct gctgtgggtg cttcttcttt gggtgccggg atcaaccggc       60

gatgcccaca agtcggaggt ggcccatcgg tttaaggacc tcggggagga gaacttcaaa      120

gccctggtcc tcatcgcctt cgcccaatac ctccagcagt gtccattcga agatcacgtg      180

aagctcgtga acgaagtgac tgaatttgcc aagacttgtg tcgcagacga aagcgccgaa      240

aactgcgaca agtcgttgca tactctcttc ggggataagc tgtgcactgt cgcaaccctt      300

agagagactt acggtgaaat ggctgattgc tgcgccaaac aagagccgga gcgcaacgag      360

tgcttcctcc aacataagga cgacaacccc aacctcccac gcctggtgcg gcctgaggtc      420

gacgtcatgt gcaccgcttt ccatgacaat gaggagactt ttctcaagaa gtatctgtac      480

gagatcgccc ggaggcaccc atacttttat gcaccggagc tccttttctt cgctaagcgg      540

tacaaggcgg cgttcactga atgctgtcag gcagcagaca aggcagcatg cctcctgccg      600

aaactggacg aacttcgcga cgagggtaaa gcgtcgtccg ccaagcagcg ccttaagtgc      660

gcctcgttgc agaagtttgg tgaacgcgca ttcaaagcgt gggccgtcgc aagactttcg      720

cagcggttcc caaaagcgga gtttgccgag gtgtccaaac tggtcaccga cctgaccaag      780

gtccacaccg agtgctgcca cggcgatctg ctcgaatgcg ccgacgaccg ggctgatctc      840

gcaaagtaca tttgcgagaa ccaagactcg atctcgtcaa aactgaagga atgctgcgag      900

aagccgctgt tggaaaagag ccattgtatc gccgaagtgg agaacgatga aatgcctgct      960

gatctgccaa gcctcgccgc agactttgtg gagagcaaag acgtgtgcaa gaactacgcc     1020

gaagcgaagg acgtgtttct cgggatgttc ctctacgagt acgcgcgcag gcaccctgac     1080

tactcagtgg tcctgctgtt gcggctggcc aaaacttacg aaaccaccct cgaaaagtgc     1140

tgcgcggctg ccgatccaca tgaatgctac gcaaaggtgt tcgatgaatt taagcctctg     1200

gtggaggaac cacagaacct gatcaagcaa aattgtgaac tgtttgaaca gctgggagag     1260

tacaaatttc agaatgccct gctggtcaga tacactaaga aggtgcccca agtctccact     1320

ccaaccctcg tggaggtgtc acggaatctc ggcaaagtgg gcagcaaatg ctgtaagcac     1380

ccggaagcaa agaggatgcc ctgcgctgaa gattacctgt ccgtggtgct gaatcagctt     1440

tgtgtgctgc acgaaaagac gcctgtctcc gaccgggtga ccaagtgctg taccgaatcg     1500

ctcgtgaatc gcagaccctg cttctccgct ctcgaagtgg acgaaactta cgtcccgaag     1560

gagttcaatg cggaaacctt caccttccac gcggacatct gtaccctgag cgaaaaagag     1620

cggcagatca agaaacagac tgccctggtg gaactggtga agcacaagcc gaaggcaacg     1680

aaggagcagc tgaaggcggt gatggatgac tttgcagcct tcgtggaaaa gtgttgcaag     1740

gcagatgata aagaaacctg tttcgcggaa gaggggaaga agttggtggc tgccagccag     1800

gccgctctcg gactgggagg tggaggatca ggaggcggag gctccggagg aggaggctcg     1860

gctcacgccg gcgatcattg cccgctcgga ccgggacgct gctgcagact gcataccgtc     1920

cgcgcttcct tggaagatct gggatgggcg gattgggtgt tgtcaccaag agaggtgcaa     1980

gtgacgatgt gtatcggtgc gtgcccttca cagttccgcg ctgcgaacat gcatgcccaa     2040

atcaagacca gcctgcaccg gctgaagccg gacactgtcc cagctccatg ttgcgtgccc     2100

gcatcgtaca acccgatggt gctcatccag aaaactgaca ctggagtctc actgcaaacg     2160

tacgacgatt tgctcgccaa agattgccac tgcatt                               2196


<210> 40
<211> 712
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 40
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Gly Ser Ala His Ala Gly Asp His Cys Pro 
        595                 600                 605             


Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu 
    610                 615                 620                 


Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln 
625                 630                 635                 640 


Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn 
                645                 650                 655     


Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr 
            660                 665                 670         


Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu 
        675                 680                 685             


Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu 
    690                 695                 700                 


Leu Ala Lys Asp Cys His Cys Ile 
705                 710         


<210> 41
<211> 2196
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 41
atggaaaccg atactctgct gctgtgggtg cttcttcttt gggtgccggg atcaaccggc       60

gatgcccaca agtcggaggt ggcccatcgg tttaaggacc tcggggagga gaacttcaaa      120

gccctggtcc tcatcgcctt cgcccaatac ctccagcagt gtccattcga agatcacgtg      180

aagctcgtga acgaagtgac tgaatttgcc aagacttgtg tcgcagacga aagcgccgaa      240

aactgcgaca agtcgttgca tactctcttc ggggataagc tgtgcactgt cgcaaccctt      300

agagagactt acggtgaaat ggctgattgc tgcgccaaac aagagccgga gcgcaacgag      360

tgcttcctcc aacataagga cgacaacccc aacctcccac gcctggtgcg gcctgaggtc      420

gacgtcatgt gcaccgcttt ccatgacaat gaggagactt ttctcaagaa gtatctgtac      480

gagatcgccc ggaggcaccc atacttttat gcaccggagc tccttttctt cgctaagcgg      540

tacaaggcgg cgttcactga atgctgtcag gcagcagaca aggcagcatg cctcctgccg      600

aaactggacg aacttcgcga cgagggtaaa gcgtcgtccg ccaagcagcg ccttaagtgc      660

gcctcgttgc agaagtttgg tgaacgcgca ttcaaagcgt gggccgtcgc aagactttcg      720

cagcggttcc caaaagcgga gtttgccgag gtgtccaaac tggtcaccga cctgaccaag      780

gtccacaccg agtgctgcca cggcgatctg ctcgaatgcg ccgacgaccg ggctgatctc      840

gcaaagtaca tttgcgagaa ccaagactcg atctcgtcaa aactgaagga atgctgcgag      900

aagccgctgt tggaaaagag ccattgtatc gccgaagtgg agaacgatga aatgcctgct      960

gatctgccaa gcctcgccgc agactttgtg gagagcaaag acgtgtgcaa gaactacgcc     1020

gaagcgaagg acgtgtttct cgggatgttc ctctacgagt acgcgcgcag gcaccctgac     1080

tactcagtgg tcctgctgtt gcggctggcc aaaacttacg aaaccaccct cgaaaagtgc     1140

tgcgcggctg ccgatccaca tgaatgctac gcaaaggtgt tcgatgaatt taagcctctg     1200

gtggaggaac cacagaacct gatcaagcaa aattgtgaac tgtttgaaca gctgggagag     1260

tacaaatttc agaatgccct gctggtcaga tacactaaga aggtgcccca agtctccact     1320

ccaaccctcg tggaggtgtc acggaatctc ggcaaagtgg gcagcaaatg ctgtaagcac     1380

ccggaagcaa agaggatgcc ctgcgctgaa gattacctgt ccgtggtgct gaatcagctt     1440

tgtgtgctgc acgaaaagac gcctgtctcc gaccgggtga ccaagtgctg taccgaatcg     1500

ctcgtgaatc gcagaccctg cttctccgct ctcgaagtgg acgaaactta cgtcccgaag     1560

gagttcaatg cggaaacctt caccttccac gcggacatct gtaccctgag cgaaaaagag     1620

cggcagatca agaaacagac tgccctggtg gaactggtga agcacaagcc gaaggcaacg     1680

aaggagcagc tgaaggcggt gatggatgac tttgcagcct tcgtggaaaa gtgttgcaag     1740

gcagatgata aagaaacctg tttcgcggaa gaggggaaga agttggtggc tgccagccag     1800

gccgctctcg gactgggagg tggaggatca ggaggcggag gctccggagg aggaggctcg     1860

gctcgcgagg gcgatcattg cccgctcgga ccgggacgct gctgcagact gcataccgtc     1920

cgcgcttcct tggaagatct gggatgggcg gattgggtgt tgtcaccaag agaggtgcaa     1980

gtgacgatgt gtatcggtgc gtgcccttca cagttccgcg ctgcgaacat gcatgcccaa     2040

atcaagacca gcctgcaccg gctgaagccg gacactgtcc cagctccatg ttgcgtgccc     2100

gcatcgtaca acccgatggt gctcatccag aaaactgaca ctggagtctc actgcaaacg     2160

tacgacgatt tgctcgccaa agattgccac tgcatt                               2196


<210> 42
<211> 712
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Gly Ser Ala Arg Glu Gly Asp His Cys Pro 
        595                 600                 605             


Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu 
    610                 615                 620                 


Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln 
625                 630                 635                 640 


Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn 
                645                 650                 655     


Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr 
            660                 665                 670         


Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu 
        675                 680                 685             


Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu 
    690                 695                 700                 


Leu Ala Lys Asp Cys His Cys Ile 
705                 710         


<210> 43
<211> 7
<212> PRT
<213> Homo sapiens

<400> 43
Arg Gly Arg Arg Arg Ala Arg 
1               5           


<210> 44
<211> 112
<212> PRT
<213> Homo sapiens

<400> 44
Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210> 45
<211> 585
<212> PRT
<213> Homo sapiens

<400> 45
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210> 46
<211> 100
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (6)..(100)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(100)
<223> /note="This sequence may encompass 1-20 'Gly Gly Gly Gly Ser'
      repeating units, wherein some positions may be absent"

<220>
<221> misc_feature
<222> (1)..(100)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 46
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser 
            100 


<210> 47
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 48
<211> 100
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (6)..(100)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(100)
<223> /note="This sequence may encompass 1-20 'Gly Pro Pro Gly Ser'
      repeating units, wherein some positions may be absent"

<220>
<221> misc_feature
<222> (1)..(100)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 48
Gly Pro Pro Gly Ser Gly Pro Pro Gly Ser Gly Pro Pro Gly Ser Gly 
1               5                   10                  15      


Pro Pro Gly Ser Gly Pro Pro Gly Ser Gly Pro Pro Gly Ser Gly Pro 
            20                  25                  30          


Pro Gly Ser Gly Pro Pro Gly Ser Gly Pro Pro Gly Ser Gly Pro Pro 
        35                  40                  45              


Gly Ser Gly Pro Pro Gly Ser Gly Pro Pro Gly Ser Gly Pro Pro Gly 
    50                  55                  60                  


Ser Gly Pro Pro Gly Ser Gly Pro Pro Gly Ser Gly Pro Pro Gly Ser 
65                  70                  75                  80  


Gly Pro Pro Gly Ser Gly Pro Pro Gly Ser Gly Pro Pro Gly Ser Gly 
                85                  90                  95      


Pro Pro Gly Ser 
            100 


<210> 49
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Gly Pro Pro Gly Ser 
1               5   


<210> 50
<211> 100
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> VARIANT
<222> (6)..(100)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(100)
<223> /note="This sequence may encompass 1-20 'Gly Ser Gly Gly Gly'
      repeating units, wherein some positions may be absent"

<220>
<221> misc_feature
<222> (1)..(100)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 50
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                85                  90                  95      


Ser Gly Gly Gly 
            100 


<210> 51
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Gly Ser Gly Gly Gly 
1               5   


<210> 52
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Gly Ser Gly Gly 
1               


<210> 53
<211> 80
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (5)..(80)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(80)
<223> /note="This sequence may encompass 1-20 'Ser Gly Gly Gly'
      repeating units, wherein some positions may be absent"

<220>
<221> misc_feature
<222> (1)..(80)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 53
Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
65                  70                  75                  80  


<210> 54
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Gly Gly Gly Gly Ser 
1               5   


<210> 55
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
Gly Gly Gly Ser 
1               


<210> 56
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Gly Gly Ser 
1           


<210> 57
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Gly Ser 
1       


<210> 58
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Ser Gly Gly Gly Gly 
1               5   


<210> 59
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Ser Gly Gly Gly 
1               


<210> 60
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Ser Gly Gly 
1           


<210> 61
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 61
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
1               5                   10                       


<210> 62
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 62
Gly Gly Gly Gly Ala 
1               5   


<210> 63
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
Gly Gly Gly Ala 
1               


<210> 64
<211> 100
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (6)..(100)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(100)
<223> /note="This sequence may encompass 1-20 'Glu Ala Ala Ala Lys'
      repeating units, wherein some positions may be absent"

<220>
<221> misc_feature
<222> (1)..(100)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 64
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
        35                  40                  45              


Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
    50                  55                  60                  


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
                85                  90                  95      


Ala Ala Ala Lys 
            100 


<210> 65
<211> 2196
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 65
atggagactg ataccctgct cctctgggtg ctgcttctct gggtccctgg ctcaaccggc       60

gaagcccaca agtccgagat cgcccatcgc tataatgctc ttggagaaca gcatttcaag      120

ggactggtgc tgattgcctt ctcccagtac ctccaaaagg ccagctatga tgagcacgcc      180

aagctcgtcc aagaagtcac cgactttgct aagacttgtg tggccgacga aagcgctgcc      240

aattgcgata agtcactcca tactctcttc ggggacaagc tgtgcgctat tcccaacctc      300

cgcgagaatt acggtgagct ggccgactgt tgcaccaaac aggagccaga gcggaacgag      360

tgcttccttc aacacaaaga tgacaatcct tcactgcctc ctttcgaacg gcccgaggca      420

gaggcaatgt gcactagctt caaggagaac ccaaccacct tcatgggaca ctacctccat      480

gaggtcgcta gacggcatcc ctacttctat gccccagagc ttctgtatta tgcagaacag      540

tacaatgaga tcctgaccca gtgctgtgct gaggctgata aggagagctg cctgacccca      600

aagctcgacg gagtgaagga aaaggctctt gtgtccagcg tgcggcagcg catgaagtgc      660

tcttcaatgc agaagtttgg ggagcgcgcc ttcaaagcct gggccgtggc cagactgtcc      720

cagacctttc ctaatgctga ctttgccgag atcaccaagc tcgctactga cctgaccaag      780

gtcaacaaag agtgttgcca cggagatctg ctcgaatgcg ccgacgaccg cgctgagctt      840

gctaagtaca tgtgcgaaaa ccaggcaacc atttctagca agctgcagac ctgttgtgat      900

aagcctctgc tgaagaaagc ccattgcctc agcgaggtcg aacatgacac tatgccggca      960

gacctccccg ctatcgccgc tgacttcgtg gaggaccaag aagtgtgcaa gaattacgcc     1020

gaggctaagg acgtgttcct tggtactttc ctctacgagt atagccggag gcaccctgac     1080

tacagcgtgt ctcttctgct tcggctcgcc aagaagtacg aagccaccct cgaaaaatgc     1140

tgcgccgaag caaatccgcc agcttgttac gggactgtgc tggctgagtt tcagcccctg     1200

gtggaagagc ccaagaacct cgtcaagacc aactgcgacc tttacgagaa actgggtgaa     1260

tacgggtttc agaatgccat tctggtgcgg tacacccaga aggcaccaca agtgtccacc     1320

ccaacccttg tcgaggcagc ccgcaacctt ggacgcgtcg ggaccaagtg ttgtaccctg     1380

cccgaggacc aacgcctgcc ctgcgtcgag gactacctta gcgccattct gaacagagtc     1440

tgtctgctcc atgaaaagac ccctgtgtct gagcacgtga ccaagtgctg ttcaggctca     1500

ctggtggaga ggaggccttg cttttctgcc ctgaccgtgg acgaaaccta cgtgcccaag     1560

gagttcaaag ctgaaacctt cactttccat tcagacatct gtaccctccc cgaaaaggaa     1620

aagcaaatca agaagcagac cgcccttgct gaactggtga agcacaagcc aaaggccacc     1680

gccgaacaac tcaagactgt gatggacgac ttcgctcagt tcctcgacac ttgctgcaaa     1740

gccgccgaca aagatacctg tttctcaacc gaggggccga acctggtgac tagagccaag     1800

gacgccctgg ccggaggagg tggttctggc ggtggtggtt ccggcggagg aggatctgcc     1860

aggaatggag atcactgccc actcggaccg ggacggtgtt gtcgcctgca cactgtgcgc     1920

gcatctcttg aggatctggg atgggctgat tgggtgctct ctcccagaga ggtgcaagtc     1980

accatgtgca ttggcgcctg cccctccagg ttcagggcag ctaacatgca tgctcagatc     2040

aagactagcc tgcacaggct gaagcccgac actgtccctg ccccatgttg tgtgccggcc     2100

tcctataacc caatggtcct gatccaaaag accgataccg gagtgtcact tcagacttac     2160

gacgatctgc ttgcaaaaga ctgccattgc atctga                               2196


<210> 66
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 66
Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Ala Leu Gly Glu 
1               5                   10                  15      


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Lys Ala Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         


Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             


Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 


Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     


Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         


Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro 
    210                 215                 220                 


Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 
            260                 265                 270         


Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His 
        275                 280                 285             


Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala 
    290                 295                 300                 


Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 
            340                 345                 350         


Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala 
        355                 360                 365             


Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu 
385                 390                 395                 400 


Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 
            420                 425                 430         


Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys 
        435                 440                 445             


Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser 
465                 470                 475                 480 


Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 
            500                 505                 510         


Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu 
    530                 535                 540                 


Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys 
545                 550                 555                 560 


Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val 
                565                 570                 575     


Thr Arg Ala Lys Asp Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser Ala Arg Asn Gly Asp His Cys Pro Leu 
        595                 600                 605             


Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu 
    610                 615                 620                 


Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val 
625                 630                 635                 640 


Thr Met Cys Ile Gly Ala Cys Pro Ser Arg Phe Arg Ala Ala Asn Met 
                645                 650                 655     


His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val 
            660                 665                 670         


Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile 
        675                 680                 685             


Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu 
    690                 695                 700                 


Ala Lys Asp Cys His Cys Ile 
705                 710     


<210> 67
<211> 2196
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 67
atggagactg ataccctgct cctctgggtg ctgcttctct gggtccctgg ctcaaccggc       60

gaagcccaca agtccgagat cgcccatcgc tataatgctc ttggagaaca gcatttcaag      120

ggactggtgc tgattgcctt ctcccagtac ctccaaaagg ccagctatga tgagcacgcc      180

aagctcgtcc aagaagtcac cgactttgct aagacttgtg tggccgacga aagcgctgcc      240

aattgcgata agtcactcca tactctcttc ggggacaagc tgtgcgctat tcccaacctc      300

cgcgagaatt acggtgagct ggccgactgt tgcaccaaac aggagccaga gcggaacgag      360

tgcttccttc aacacaaaga tgacaatcct tcactgcctc ctttcgaacg gcccgaggca      420

gaggcaatgt gcactagctt caaggagaac ccaaccacct tcatgggaca ctacctccat      480

gaggtcgcta gacggcatcc ctacttctat gccccagagc ttctgtatta tgcagaacag      540

tacaatgaga tcctgaccca gtgctgtgct gaggctgata aggagagctg cctgacccca      600

aagctcgacg gagtgaagga aaaggctctt gtgtccagcg tgcggcagcg catgaagtgc      660

tcttcaatgc agaagtttgg ggagcgcgcc ttcaaagcct gggccgtggc cagactgtcc      720

cagacctttc ctaatgctga ctttgccgag atcaccaagc tcgctactga cctgaccaag      780

gtcaacaaag agtgttgcca cggagatctg ctcgaatgcg ccgacgaccg cgctgagctt      840

gctaagtaca tgtgcgaaaa ccaggcaacc atttctagca agctgcagac ctgttgtgat      900

aagcctctgc tgaagaaagc ccattgcctc agcgaggtcg aacatgacac tatgccggca      960

gacctccccg ctatcgccgc tgacttcgtg gaggaccaag aagtgtgcaa gaattacgcc     1020

gaggctaagg acgtgttcct tggtactttc ctctacgagt atagccggag gcaccctgac     1080

tacagcgtgt ctcttctgct tcggctcgcc aagaagtacg aagccaccct cgaaaaatgc     1140

tgcgccgaag caaatccgcc agcttgttac gggactgtgc tggctgagtt tcagcccctg     1200

gtggaagagc ccaagaacct cgtcaagacc aactgcgacc tttacgagaa actgggtgaa     1260

tacgggtttc agaatgccat tctggtgcgg tacacccaga aggcaccaca agtgtccacc     1320

ccaacccttg tcgaggcagc ccgcaacctt ggacgcgtcg ggaccaagtg ttgtaccctg     1380

cccgaggacc aacgcctgcc ctgcgtcgag gactacctta gcgccattct gaacagagtc     1440

tgtctgctcc atgaaaagac ccctgtgtct gagcacgtga ccaagtgctg ttcaggctca     1500

ctggtggaga ggaggccttg cttttctgcc ctgaccgtgg acgaaaccta cgtgcccaag     1560

gagttcaaag ctgaaacctt cactttccat tcagacatct gtaccctccc cgaaaaggaa     1620

aagcaaatca agaagcagac cgcccttgct gaactggtga agcacaagcc aaaggccacc     1680

gccgaacaac tcaagactgt gatggacgac ttcgctcagt tcctcgacac ttgctgcaaa     1740

gccgccgaca aagatacctg tttctcaacc gaggggccga acctggtgac tagagccaag     1800

gacgccctgg ccggaggagg tggttctggc ggtggtggtt ccggcggagg aggatctgcc     1860

aggaatggag atcactgccc actcggaccg ggacggtgtt gtcgcctgca cactgtgcgc     1920

gcatctcttg aggatctggg atgggctgat tgggtgctct ctcccagaga ggtgcaagtc     1980

accatgtgca ttggcgcctg cccctcccaa ttcagggcag ctaacatgca tgctcagatc     2040

aagactagcc tgcacaggct gaagcccgac actgtccctg ccccatgttg tgtgccggcc     2100

aggtataacc caatggtcct gatccaaaag accgataccg gagtgtcact tcagacttac     2160

gacgatctgc ttgcaaaaga ctgccattgc atctga                               2196


<210> 68
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 68
Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Ala Leu Gly Glu 
1               5                   10                  15      


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Lys Ala Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         


Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             


Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 


Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     


Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         


Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro 
    210                 215                 220                 


Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 
            260                 265                 270         


Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His 
        275                 280                 285             


Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala 
    290                 295                 300                 


Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 
            340                 345                 350         


Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala 
        355                 360                 365             


Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu 
385                 390                 395                 400 


Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 
            420                 425                 430         


Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys 
        435                 440                 445             


Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser 
465                 470                 475                 480 


Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 
            500                 505                 510         


Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu 
    530                 535                 540                 


Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys 
545                 550                 555                 560 


Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val 
                565                 570                 575     


Thr Arg Ala Lys Asp Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser Ala Arg Asn Gly Asp His Cys Pro Leu 
        595                 600                 605             


Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu 
    610                 615                 620                 


Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val 
625                 630                 635                 640 


Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met 
                645                 650                 655     


His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val 
            660                 665                 670         


Pro Ala Pro Cys Cys Val Pro Ala Arg Tyr Asn Pro Met Val Leu Ile 
        675                 680                 685             


Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu 
    690                 695                 700                 


Ala Lys Asp Cys His Cys Ile 
705                 710     


<210> 69
<211> 2196
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 69
atggagactg ataccctgct cctctgggtg ctgcttctct gggtccctgg ctcaaccggc       60

gaagcccaca agtccgagat cgcccatcgc tataatgctc ttggagaaca gcatttcaag      120

ggactggtgc tgattgcctt ctcccagtac ctccaaaagg ccagctatga tgagcacgcc      180

aagctcgtcc aagaagtcac cgactttgct aagacttgtg tggccgacga aagcgctgcc      240

aattgcgata agtcactcca tactctcttc ggggacaagc tgtgcgctat tcccaacctc      300

cgcgagaatt acggtgagct ggccgactgt tgcaccaaac aggagccaga gcggaacgag      360

tgcttccttc aacacaaaga tgacaatcct tcactgcctc ctttcgaacg gcccgaggca      420

gaggcaatgt gcactagctt caaggagaac ccaaccacct tcatgggaca ctacctccat      480

gaggtcgcta gacggcatcc ctacttctat gccccagagc ttctgtatta tgcagaacag      540

tacaatgaga tcctgaccca gtgctgtgct gaggctgata aggagagctg cctgacccca      600

aagctcgacg gagtgaagga aaaggctctt gtgtccagcg tgcggcagcg catgaagtgc      660

tcttcaatgc agaagtttgg ggagcgcgcc ttcaaagcct gggccgtggc cagactgtcc      720

cagacctttc ctaatgctga ctttgccgag atcaccaagc tcgctactga cctgaccaag      780

gtcaacaaag agtgttgcca cggagatctg ctcgaatgcg ccgacgaccg cgctgagctt      840

gctaagtaca tgtgcgaaaa ccaggcaacc atttctagca agctgcagac ctgttgtgat      900

aagcctctgc tgaagaaagc ccattgcctc agcgaggtcg aacatgacac tatgccggca      960

gacctccccg ctatcgccgc tgacttcgtg gaggaccaag aagtgtgcaa gaattacgcc     1020

gaggctaagg acgtgttcct tggtactttc ctctacgagt atagccggag gcaccctgac     1080

tacagcgtgt ctcttctgct tcggctcgcc aagaagtacg aagccaccct cgaaaaatgc     1140

tgcgccgaag caaatccgcc agcttgttac gggactgtgc tggctgagtt tcagcccctg     1200

gtggaagagc ccaagaacct cgtcaagacc aactgcgacc tttacgagaa actgggtgaa     1260

tacgggtttc agaatgccat tctggtgcgg tacacccaga aggcaccaca agtgtccacc     1320

ccaacccttg tcgaggcagc ccgcaacctt ggacgcgtcg ggaccaagtg ttgtaccctg     1380

cccgaggacc aacgcctgcc ctgcgtcgag gactacctta gcgccattct gaacagagtc     1440

tgtctgctcc atgaaaagac ccctgtgtct gagcacgtga ccaagtgctg ttcaggctca     1500

ctggtggaga ggaggccttg cttttctgcc ctgaccgtgg acgaaaccta cgtgcccaag     1560

gagttcaaag ctgaaacctt cactttccat tcagacatct gtaccctccc cgaaaaggaa     1620

aagcaaatca agaagcagac cgcccttgct gaactggtga agcacaagcc aaaggccacc     1680

gccgaacaac tcaagactgt gatggacgac ttcgctcagt tcctcgacac ttgctgcaaa     1740

gccgccgaca aagatacctg tttctcaacc gaggggccga acctggtgac tagagccaag     1800

gacgccctgg ccggaggagg tggttctggc ggtggtggtt ccggcggagg aggatctgcc     1860

aggaatggag atcactgccc actcggaccg ggacggtgtt gtcgcctgca cactgtgcgc     1920

gcatctcttg aggatctggg atgggctgat tgggtgctct ctcccagaga ggtgcaagtc     1980

accatgtgca ttggcgcctg cccctcccaa ttcagggcag ctaacatgca tgctcagatc     2040

aagactagcc tgcacaggct gaagcccgac actgtccctg ccccatgttg tgtgccggcc     2100

tcctataacc caatggtcct gatccaaaag accaggaccg gagtgtcact tcagacttac     2160

gacgatctgc ttgcaaaaga ctgccattgc atctga                               2196


<210> 70
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 70
Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Ala Leu Gly Glu 
1               5                   10                  15      


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Lys Ala Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         


Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             


Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 


Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     


Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         


Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro 
    210                 215                 220                 


Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 
            260                 265                 270         


Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His 
        275                 280                 285             


Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala 
    290                 295                 300                 


Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 
            340                 345                 350         


Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala 
        355                 360                 365             


Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu 
385                 390                 395                 400 


Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 
            420                 425                 430         


Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys 
        435                 440                 445             


Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser 
465                 470                 475                 480 


Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 
            500                 505                 510         


Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu 
    530                 535                 540                 


Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys 
545                 550                 555                 560 


Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val 
                565                 570                 575     


Thr Arg Ala Lys Asp Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser Ala Arg Asn Gly Asp His Cys Pro Leu 
        595                 600                 605             


Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu 
    610                 615                 620                 


Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val 
625                 630                 635                 640 


Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met 
                645                 650                 655     


His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val 
            660                 665                 670         


Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile 
        675                 680                 685             


Gln Lys Thr Arg Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu 
    690                 695                 700                 


Ala Lys Asp Cys His Cys Ile 
705                 710     


<210> 71
<211> 2196
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 71
atggagactg ataccctgct cctctgggtg ctgcttctct gggtccctgg ctcaaccggc       60

gaagcccaca agtccgagat cgcccatcgc tataatgctc ttggagaaca gcatttcaag      120

ggactggtgc tgattgcctt ctcccagtac ctccaaaagg ccagctatga tgagcacgcc      180

aagctcgtcc aagaagtcac cgactttgct aagacttgtg tggccgacga aagcgctgcc      240

aattgcgata agtcactcca tactctcttc ggggacaagc tgtgcgctat tcccaacctc      300

cgcgagaatt acggtgagct ggccgactgt tgcaccaaac aggagccaga gcggaacgag      360

tgcttccttc aacacaaaga tgacaatcct tcactgcctc ctttcgaacg gcccgaggca      420

gaggcaatgt gcactagctt caaggagaac ccaaccacct tcatgggaca ctacctccat      480

gaggtcgcta gacggcatcc ctacttctat gccccagagc ttctgtatta tgcagaacag      540

tacaatgaga tcctgaccca gtgctgtgct gaggctgata aggagagctg cctgacccca      600

aagctcgacg gagtgaagga aaaggctctt gtgtccagcg tgcggcagcg catgaagtgc      660

tcttcaatgc agaagtttgg ggagcgcgcc ttcaaagcct gggccgtggc cagactgtcc      720

cagacctttc ctaatgctga ctttgccgag atcaccaagc tcgctactga cctgaccaag      780

gtcaacaaag agtgttgcca cggagatctg ctcgaatgcg ccgacgaccg cgctgagctt      840

gctaagtaca tgtgcgaaaa ccaggcaacc atttctagca agctgcagac ctgttgtgat      900

aagcctctgc tgaagaaagc ccattgcctc agcgaggtcg aacatgacac tatgccggca      960

gacctccccg ctatcgccgc tgacttcgtg gaggaccaag aagtgtgcaa gaattacgcc     1020

gaggctaagg acgtgttcct tggtactttc ctctacgagt atagccggag gcaccctgac     1080

tacagcgtgt ctcttctgct tcggctcgcc aagaagtacg aagccaccct cgaaaaatgc     1140

tgcgccgaag caaatccgcc agcttgttac gggactgtgc tggctgagtt tcagcccctg     1200

gtggaagagc ccaagaacct cgtcaagacc aactgcgacc tttacgagaa actgggtgaa     1260

tacgggtttc agaatgccat tctggtgcgg tacacccaga aggcaccaca agtgtccacc     1320

ccaacccttg tcgaggcagc ccgcaacctt ggacgcgtcg ggaccaagtg ttgtaccctg     1380

cccgaggacc aacgcctgcc ctgcgtcgag gactacctta gcgccattct gaacagagtc     1440

tgtctgctcc atgaaaagac ccctgtgtct gagcacgtga ccaagtgctg ttcaggctca     1500

ctggtggaga ggaggccttg cttttctgcc ctgaccgtgg acgaaaccta cgtgcccaag     1560

gagttcaaag ctgaaacctt cactttccat tcagacatct gtaccctccc cgaaaaggaa     1620

aagcaaatca agaagcagac cgcccttgct gaactggtga agcacaagcc aaaggccacc     1680

gccgaacaac tcaagactgt gatggacgac ttcgctcagt tcctcgacac ttgctgcaaa     1740

gccgccgaca aagatacctg tttctcaacc gaggggccga acctggtgac tagagccaag     1800

gacgccctgg ccggaggagg tggttctggc ggtggtggtt ccggcggagg aggatctgcc     1860

aggaatggag atcactgccc actcggaccg ggacggtgtt gtcgcctgca cactgtgcgc     1920

gcatctcttg aggatctggg atgggctgat tgggtgctct ctcccagaga ggtgcaagtc     1980

accatgtgca ttggcgcctg cccctcccaa ttcagggcag ctaacatgca tgctcagatc     2040

aagactagcc tgcacaggct gaagcccgac actgtccctg ccccatgttg tgtgccggcc     2100

tcctataacc caatggtcct gatccaaaag accgataccg gagtgtcaag gcagacttac     2160

gacgatctgc ttgcaaaaga ctgccattgc atctga                               2196


<210> 72
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 72
Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Ala Leu Gly Glu 
1               5                   10                  15      


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Lys Ala Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         


Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             


Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 


Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     


Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         


Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro 
    210                 215                 220                 


Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 
            260                 265                 270         


Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His 
        275                 280                 285             


Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala 
    290                 295                 300                 


Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 
            340                 345                 350         


Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala 
        355                 360                 365             


Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu 
385                 390                 395                 400 


Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 
            420                 425                 430         


Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys 
        435                 440                 445             


Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser 
465                 470                 475                 480 


Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 
            500                 505                 510         


Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu 
    530                 535                 540                 


Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys 
545                 550                 555                 560 


Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val 
                565                 570                 575     


Thr Arg Ala Lys Asp Ala Leu Ala Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser Ala Arg Asn Gly Asp His Cys Pro Leu 
        595                 600                 605             


Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu 
    610                 615                 620                 


Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val 
625                 630                 635                 640 


Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met 
                645                 650                 655     


His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val 
            660                 665                 670         


Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile 
        675                 680                 685             


Gln Lys Thr Asp Thr Gly Val Ser Arg Gln Thr Tyr Asp Asp Leu Leu 
    690                 695                 700                 


Ala Lys Asp Cys His Cys Ile 
705                 710     


<210> 73
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 73
Gly Gly Gly Gly 
1                  


<210> 74
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 74
Gly Gly Gly Gly Gly 
1               5   


<210> 75
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 75
His His His His His His 
1               5       


<210> 76
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      8xHis tag"

<400> 76
His His His His His His His His
1               5       


<210> 77
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (6)..(20)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(20)
<223> /note="This sequence may encompass 1-4 'Gly Gly Gly Gly Ser'
      repeating units, wherein some positions may be absent"

<220>
<221> misc_feature
<222> (1)..(20)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 77
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 78
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (6)..(20)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(20)
<223> /note="This sequence may encompass 1-4 'Gly Pro Pro Gly Ser'
      repeating units, wherein some positions may be absent"

<220>
<221> misc_feature
<222> (1)..(20)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 78
Gly Pro Pro Gly Ser Gly Pro Pro Gly Ser Gly Pro Pro Gly Ser Gly 
1               5                   10                  15      


Pro Pro Gly Ser 
            20  
