                         SEQUENCE LISTING

<110>  Kang, et al.
 
<120>  Use of peptides that block metadherin-SND1 interaction as 
       treatment for cancer

<130>  31256/48166 PC

<150>  US 62/016914
<151>  2014-06-25

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Arg Ser Trp Gln Asp Glu Leu Ala Gln Gln Ala Glu Glu 
1               5                   10                  15      


Gly Ser Ala Arg Leu Arg Glu Met Leu Ser Val Gly Leu Gly Phe Leu 
            20                  25                  30          


Arg Thr Glu Leu Gly Leu Asp Leu Gly Leu Glu Pro Lys Arg Tyr Pro 
        35                  40                  45              


Gly Trp Val Ile Leu Val Gly Thr Gly Ala Leu Gly Leu Leu Leu Leu 
    50                  55                  60                  


Phe Leu Leu Gly Tyr Gly Trp Ala Ala Ala Cys Ala Gly Ser Arg Lys 
65                  70                  75                  80  


Lys Arg Arg Ser Pro Pro Arg Lys Arg Glu Glu Ala Ala Ala Val Pro 
                85                  90                  95      


Ala Ala Ala Pro Asp Asp Leu Ala Leu Leu Lys Asn Leu Arg Ser Glu 
            100                 105                 110         


Glu Gln Lys Lys Lys Asn Arg Lys Lys Leu Ser Glu Lys Pro Lys Pro 
        115                 120                 125             


Asn Gly Arg Thr Val Glu Val Ala Glu Gly Glu Ala Val Arg Thr Pro 
    130                 135                 140                 


Gln Ser Val Thr Ala Lys Gln Pro Pro Glu Ile Asp Lys Lys Asn Glu 
145                 150                 155                 160 


Lys Ser Lys Lys Asn Lys Lys Lys Ser Lys Ser Asp Ala Lys Ala Val 
                165                 170                 175     


Gln Asn Ser Ser Arg His Asp Gly Lys Glu Val Asp Glu Gly Ala Trp 
            180                 185                 190         


Glu Thr Lys Ile Ser His Arg Glu Lys Arg Gln Gln Arg Lys Arg Asp 
        195                 200                 205             


Lys Val Leu Thr Asp Ser Gly Ser Leu Asp Ser Thr Ile Pro Gly Ile 
    210                 215                 220                 


Glu Asn Thr Ile Thr Val Thr Thr Glu Gln Leu Thr Thr Ala Ser Phe 
225                 230                 235                 240 


Pro Val Gly Ser Lys Lys Asn Lys Gly Asp Ser His Leu Asn Val Gln 
                245                 250                 255     


Val Ser Asn Phe Lys Ser Gly Lys Gly Asp Ser Thr Leu Gln Val Ser 
            260                 265                 270         


Ser Gly Leu Asn Glu Asn Leu Thr Val Asn Gly Gly Gly Trp Asn Glu 
        275                 280                 285             


Lys Ser Val Lys Leu Ser Ser Gln Ile Ser Ala Gly Glu Glu Lys Trp 
    290                 295                 300                 


Asn Ser Val Ser Pro Ala Ser Ala Gly Lys Arg Lys Ala Glu Pro Ser 
305                 310                 315                 320 


Ala Trp Ser Gln Asp Thr Gly Asp Ala Asn Thr Asn Gly Lys Asp Trp 
                325                 330                 335     


Gly Arg Ser Trp Ser Asp Arg Ser Ile Phe Ser Gly Ile Gly Ser Thr 
            340                 345                 350         


Ala Glu Pro Val Ser Gln Ser Thr Thr Ser Asp Tyr Gln Trp Asp Val 
        355                 360                 365             


Ser Arg Asn Gln Pro Tyr Ile Asp Asp Glu Trp Ser Gly Leu Asn Gly 
    370                 375                 380                 


Leu Ser Ser Ala Asp Pro Asn Ser Asp Trp Asn Ala Pro Ala Glu Glu 
385                 390                 395                 400 


Trp Gly Asn Trp Val Asp Glu Glu Arg Ala Ser Leu Leu Lys Ser Gln 
                405                 410                 415     


Glu Pro Ile Pro Asp Asp Gln Lys Val Ser Asp Asp Asp Lys Glu Lys 
            420                 425                 430         


Gly Glu Gly Ala Leu Pro Thr Gly Lys Ser Lys Lys Lys Lys Lys Lys 
        435                 440                 445             


Lys Lys Lys Gln Gly Glu Asp Asn Ser Thr Ala Gln Asp Thr Glu Glu 
    450                 455                 460                 


Leu Glu Lys Glu Ile Arg Glu Asp Leu Pro Val Asn Thr Ser Lys Thr 
465                 470                 475                 480 


Arg Pro Lys Gln Glu Lys Ala Phe Ser Leu Lys Thr Ile Ser Thr Ser 
                485                 490                 495     


Asp Pro Ala Glu Val Leu Val Lys Asn Ser Gln Pro Ile Lys Thr Leu 
            500                 505                 510         


Pro Pro Ala Thr Ser Thr Glu Pro Ser Val Ile Leu Ser Lys Ser Asp 
        515                 520                 525             


Ser Asp Lys Ser Ser Ser Gln Val Pro Pro Ile Leu Gln Glu Thr Asp 
    530                 535                 540                 


Lys Ser Lys Ser Asn Thr Lys Gln Asn Ser Val Pro Pro Ser Gln Thr 
545                 550                 555                 560 


Lys Ser Glu Thr Ser Trp Glu Ser Pro Lys Gln Ile Lys Lys Lys Lys 
                565                 570                 575     


Lys Ala Arg Arg Glu Thr 
            580         


<210>  2
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Ser Ala Gln Ser Gly Gly Ser Ser Gly Gly Pro Ala Val 
1               5                   10                  15      


Pro Thr Val Gln Arg Gly Ile Ile Lys Met Val Leu Ser Gly Cys Ala 
            20                  25                  30          


Ile Ile Val Arg Gly Gln Pro Arg Gly Gly Pro Pro Pro Glu Arg Gln 
        35                  40                  45              


Ile Asn Leu Ser Asn Ile Arg Ala Gly Asn Leu Ala Arg Arg Ala Ala 
    50                  55                  60                  


Ala Thr Gln Pro Asp Ala Lys Asp Thr Pro Asp Glu Pro Trp Ala Phe 
65                  70                  75                  80  


Pro Ala Arg Glu Phe Leu Arg Lys Lys Leu Ile Gly Lys Glu Val Cys 
                85                  90                  95      


Phe Thr Ile Glu Asn Lys Thr Pro Gln Gly Arg Glu Tyr Gly Met Ile 
            100                 105                 110         


Tyr Leu Gly Lys Asp Thr Asn Gly Glu Asn Ile Ala Glu Ser Leu Val 
        115                 120                 125             


Ala Glu Gly Leu Ala Thr Arg Arg Glu Gly Met Arg Ala Asn Asn Pro 
    130                 135                 140                 


Glu Gln Asn Arg Leu Ser Glu Cys Glu Glu Gln Ala Lys Ala Ala Lys 
145                 150                 155                 160 


Lys Gly Met Trp Ser Glu Gly Asn Gly Ser His Thr Ile Arg Asp Leu 
                165                 170                 175     


Lys Tyr Thr Ile Glu Asn Pro Arg His Phe Val Asp Ser His His Gln 
            180                 185                 190         


Lys Pro Val Asn Ala Ile Ile Glu His Val Arg Asp Gly Ser Val Val 
        195                 200                 205             


Arg Ala Leu Leu Leu Pro Asp Tyr Tyr Leu Val Thr Val Met Leu Ser 
    210                 215                 220                 


Gly Ile Lys Cys Pro Thr Phe Arg Arg Glu Ala Asp Gly Ser Glu Thr 
225                 230                 235                 240 


Pro Glu Pro Phe Ala Ala Glu Ala Lys Phe Phe Thr Glu Ser Arg Leu 
                245                 250                 255     


Leu Gln Arg Asp Val Gln Ile Ile Leu Glu Ser Cys His Asn Gln Asn 
            260                 265                 270         


Ile Leu Gly Thr Ile Leu His Pro Asn Gly Asn Ile Thr Glu Leu Leu 
        275                 280                 285             


Leu Lys Glu Gly Phe Ala Arg Cys Val Asp Trp Ser Ile Ala Val Tyr 
    290                 295                 300                 


Thr Arg Gly Ala Glu Lys Leu Arg Ala Ala Glu Arg Phe Ala Lys Glu 
305                 310                 315                 320 


Arg Arg Leu Arg Ile Trp Arg Asp Tyr Val Ala Pro Thr Ala Asn Leu 
                325                 330                 335     


Asp Gln Lys Asp Lys Gln Phe Val Ala Lys Val Met Gln Val Leu Asn 
            340                 345                 350         


Ala Asp Ala Ile Val Val Lys Leu Asn Ser Gly Asp Tyr Lys Thr Ile 
        355                 360                 365             


His Leu Ser Ser Ile Arg Pro Pro Arg Leu Glu Gly Glu Asn Thr Gln 
    370                 375                 380                 


Asp Lys Asn Lys Lys Leu Arg Pro Leu Tyr Asp Ile Pro Tyr Met Phe 
385                 390                 395                 400 


Glu Ala Arg Glu Phe Leu Arg Lys Lys Leu Ile Gly Lys Lys Val Asn 
                405                 410                 415     


Val Thr Val Asp Tyr Ile Arg Pro Ala Ser Pro Ala Thr Glu Thr Val 
            420                 425                 430         


Pro Ala Phe Ser Glu Arg Thr Cys Ala Thr Val Thr Ile Gly Gly Ile 
        435                 440                 445             


Asn Ile Ala Glu Ala Leu Val Ser Lys Gly Leu Ala Thr Val Ile Arg 
    450                 455                 460                 


Tyr Arg Gln Asp Asp Asp Gln Arg Ser Ser His Tyr Asp Glu Leu Leu 
465                 470                 475                 480 


Ala Ala Glu Ala Arg Ala Ile Lys Asn Gly Lys Gly Leu His Ser Lys 
                485                 490                 495     


Lys Glu Val Pro Ile His Arg Val Ala Asp Ile Ser Gly Asp Thr Gln 
            500                 505                 510         


Lys Ala Lys Gln Phe Leu Pro Phe Leu Gln Arg Ala Gly Arg Ser Glu 
        515                 520                 525             


Ala Val Val Glu Tyr Val Phe Ser Gly Ser Arg Leu Lys Leu Tyr Leu 
    530                 535                 540                 


Pro Lys Glu Thr Cys Leu Ile Thr Phe Leu Leu Ala Gly Ile Glu Cys 
545                 550                 555                 560 


Pro Arg Gly Ala Arg Asn Leu Pro Gly Leu Val Gln Glu Gly Glu Pro 
                565                 570                 575     


Phe Ser Glu Glu Ala Thr Leu Phe Thr Lys Glu Leu Val Leu Gln Arg 
            580                 585                 590         


Glu Val Glu Val Glu Val Glu Ser Met Asp Lys Ala Gly Asn Phe Ile 
        595                 600                 605             


Gly Trp Leu His Ile Asp Gly Ala Asn Leu Ser Val Leu Leu Val Glu 
    610                 615                 620                 


His Ala Leu Ser Lys Val His Phe Thr Ala Glu Arg Ser Ser Tyr Tyr 
625                 630                 635                 640 


Lys Ser Leu Leu Ser Ala Glu Glu Ala Ala Lys Gln Lys Lys Glu Lys 
                645                 650                 655     


Val Trp Ala His Tyr Glu Glu Gln Pro Val Glu Glu Val Met Pro Val 
            660                 665                 670         


Leu Glu Glu Lys Glu Arg Ser Ala Ser Tyr Lys Pro Val Phe Val Thr 
        675                 680                 685             


Glu Ile Thr Asp Asp Leu His Phe Tyr Val Gln Asp Val Glu Thr Gly 
    690                 695                 700                 


Thr Gln Leu Glu Lys Leu Met Glu Asn Met Arg Asn Asp Ile Ala Ser 
705                 710                 715                 720 


His Pro Pro Val Glu Gly Ser Tyr Ala Pro Arg Arg Gly Glu Phe Cys 
                725                 730                 735     


Ile Ala Lys Phe Val Asp Gly Glu Trp Tyr Arg Ala Arg Val Glu Lys 
            740                 745                 750         


Val Glu Ser Pro Ala Lys Ile His Val Phe Tyr Ile Asp Tyr Gly Asn 
        755                 760                 765             


Arg Glu Val Leu Pro Ser Thr Arg Leu Gly Thr Leu Ser Pro Ala Phe 
    770                 775                 780                 


Ser Thr Arg Val Leu Pro Ala Gln Ala Thr Glu Tyr Ala Phe Ala Phe 
785                 790                 795                 800 


Ile Gln Val Pro Gln Asp Asp Asp Ala Arg Thr Asp Ala Val Asp Ser 
                805                 810                 815     


Val Val Arg Asp Ile Gln Asn Thr Gln Cys Leu Leu Asn Val Glu His 
            820                 825                 830         


Leu Ser Ala Gly Cys Pro His Val Thr Leu Gln Phe Ala Asp Ser Lys 
        835                 840                 845             


Gly Asp Val Gly Leu Gly Leu Val Lys Glu Gly Leu Val Met Val Glu 
    850                 855                 860                 


Val Arg Lys Glu Lys Gln Phe Gln Lys Val Ile Thr Glu Tyr Leu Asn 
865                 870                 875                 880 


Ala Gln Glu Ser Ala Lys Ser Ala Arg Leu Asn Leu Trp Arg Tyr Gly 
                885                 890                 895     


Asp Phe Arg Ala Asp Asp Ala Asp Glu Phe Gly Tyr Ser Arg 
            900                 905                 910 


<210>  3
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Xaa Trp Xaa Xaa Xaa Xaa Xaa Xaa Trp Xaa Xaa 
1               5                   10      


<210>  4
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Xaa Trp Xaa Xaa Xaa Xaa Xaa Trp Xaa Xaa 
1               5                   10  


<210>  5
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Trp Asn Ala Pro Ala Glu Glu Trp Gly Asn 
1               5                   10      


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  6
ctgcaaaaca agcaccagag                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  7
gttttcccag tcacgacgtt                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  8
gagaggaggt tttggggaag                                                   20


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  9
cccatgtcta aaaagccaat c                                                 21


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  10
gagaggaggt tttggggaag                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  11
gttcatatgg tgccgtgcag                                                   20


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  12
caagactctt cctcctgcta tctc                                              24


<210>  13
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  13
cccattcatc agttccatag gttg                                              24


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  14
caaatgttgc ttgtctggtg                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  15
gtcagtcgag tgcacagttt                                                   20


<210>  16
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  16

Pro Asn Ser Asp Trp Asn Ala Pro Ala Glu Glu Trp Gly Asn Trp 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  17

Pro Asn Ser Asp Ala Asn Ala Pro Ala Glu Glu Trp Gly Asn Trp 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  18

Pro Asn Ser Asp Trp Asn Ala Pro Ala Glu Glu Ala Gly Asn Trp 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  19

Pro Asn Ser Asp Ala Asn Ala Pro Ala Glu Glu Ala Gly Asn Trp 
1               5                   10                  15  


<210>  20
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Trp Asn Ala Pro Glu Glu Trp Gly Asn 
1               5                   10  


