                         SEQUENCE LISTING

<110>  The Rockefeller University
       Nussenzweig, Michel
       Halper-Stromberg, Ariel
       Lu, Ching-Lan
 
<120>  Combination of Broadly Neutralizing HIV Antibodies and Viral 
       Inducers

<130>  RU1204/070413.20225

<150>  62/026,915
<151>  2014-07-21

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp Phe Asp Thr 
65                  70                  75                  80  


Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp Asp Thr Ala 
                85                  90                  95      


Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


<210>  2
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Gly Ser 
        35                  40                  45              


Lys Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly Arg Arg Trp Gly 
    50                  55                  60                  


Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu Gln Pro Glu Asp Ile Ala 
65                  70                  75                  80  


Thr Tyr Phe Cys Gln Val Tyr Glu Phe Val Val Pro Gly Thr Arg Leu 
                85                  90                  95      


Asp Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
            100                 105                 110         


Ser Asp 
        


<210>  3
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Val His Leu Ser Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Lys Ile Ser Asp His 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg Gln Ala Ser Trp Asp Phe Asp Thr 
65                  70                  75                  80  


Tyr Ser Phe Tyr Met Asp Leu Lys Ala Val Arg Ser Asp Asp Thr Ala 
                85                  90                  95      


Ile Tyr Phe Cys Ala Arg Gln Arg Ser Asp Phe Trp Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


<210>  4
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Gly Ser 
        35                  40                  45              


Lys Leu Glu Arg Gly Val Pro Ala Arg Phe Ser Gly Arg Arg Trp Gly 
    50                  55                  60                  


Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu Gln Pro Glu Asp Val Ala 
65                  70                  75                  80  


Thr Tyr Phe Cys Gln Val Tyr Glu Phe Ile Val Pro Gly Thr Arg Leu 
                85                  90                  95      


Asp Leu Lys Arg Thr Val Ala Ala 
            100                 


<210>  5
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Gln Gln Leu Val Gln Ser Gly Thr Gln Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Gln Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Val Leu His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Val Tyr Gly Ala Arg Asn Tyr Ala Arg Arg Phe 
    50                  55                  60                  


Gln Gly Arg Ile Asn Phe Asp Arg Asp Ile Tyr Arg Glu Ile Ala Phe 
65                  70                  75                  80  


Met Asp Leu Ser Gly Leu Arg Ser Asp Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Gly Asp Asp Thr Ser Trp His Leu Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Ile Val Ser Ala Ala Ser Thr Lys Gly 
        115                 120                 125         


<210>  6
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Gly Gln Gly Ile Gly Ser Ser 
            20                  25                  30          


Leu Gln Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val 
        35                  40                  45              


His Gly Ala Ser Asn Leu His Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Thr Phe Ser Leu Thr Ile Ser Gly Leu Gln Arg 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Phe Cys Ala Val Leu Glu Phe Phe Gly Pro 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120             


<210>  7
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Gln His Leu Val Gln Ser Gly Thr Gln Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ile Leu His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Lys Pro Val Phe Gly Ala Val Asn Tyr Ala Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Ile Gln Leu Thr Arg Asp Ile Tyr Arg Glu Ile Ala Phe 
65                  70                  75                  80  


Leu Asp Leu Ser Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Ser Gly Asp Asp Leu Lys Trp His Leu His Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Ile Val Ser Pro Ala Ser Thr Lys Gly 
        115                 120                 125         


<210>  8
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Gly Gln Gly Ile Gly Ser Ser 
            20                  25                  30          


Leu Asn Trp Tyr Gln Lys Lys Pro Gly Arg Ala Pro Lys Leu Leu Val 
        35                  40                  45              


His Gly Ala Ser Asn Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Thr Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Val Ala Thr Tyr Phe Cys Ala Val Phe Gln Trp Phe Gly Pro 
                85                  90                  95      


Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120         


<210>  9
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Leu Ser Cys Arg Ala Ser Gly Tyr Glu Phe Leu Asn Cys 
            20                  25                  30          


Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Arg Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Tyr Cys Thr Ala Arg Asp Tyr Tyr Asn Trp Asp Phe 
            100                 105                 110         


Glu His 
        


<210>  10
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Ser Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Ala Asp Tyr Asn Leu Ser Ile Ser Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe 
                85                  90      


<210>  11
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Gly Gln Leu Val Gln Ser Gly Gly Gly Leu Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Ala Ser Glu Tyr Thr Phe Asn Glu Phe 
            20                  25                  30          


Val Ile His Trp Ile Arg Gln Ala Pro Gly Gln Gly Pro Leu Trp Leu 
        35                  40                  45              


Gly Leu Ile Lys Arg Ser Gly Arg Leu Met Thr Ala Tyr Asn Phe Gln 
    50                  55                  60                  


Asp Arg Leu Arg Leu Arg Arg Asp Arg Ser Thr Gly Thr Val Phe Met 
65                  70                  75                  80  


Glu Leu Arg Gly Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Leu Gly Glu Val Ala Pro Asp Tyr Arg Tyr Gly Ile Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Ser Thr Val Ile Val Thr Ala Ala Ser Thr Lys 
        115                 120                 125             


Gly 
    


<210>  12
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Leu Asn Phe Val 
            20                  25                  30          


Val Trp Tyr Gln Gln Lys Arg Gly Gln Ala Pro Arg Leu Leu Ile His 
        35                  40                  45              


Ala Pro Ser Gly Arg Ala Pro Gly Val Pro Asp Arg Phe Ser Ala Arg 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Ser Leu Val Ile Ser Ser Val Glu Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Ile Tyr Tyr Cys Gln Glu Tyr Ser Ser Thr Pro Tyr Asn 
                85                  90                  95      


Phe Gly Pro Gly Thr Arg Val Asp Arg Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120             


<210>  13
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln Gly Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Ala Ser Glu Tyr Thr Phe Asn Glu Phe 
            20                  25                  30          


Val Ile His Trp Ile Arg Gln Ala Pro Gly Gln Gly Pro Val Trp Leu 
        35                  40                  45              


Gly Leu Ile Lys Arg Ser Gly Arg Leu Met Thr Ser Tyr Lys Phe Gln 
    50                  55                  60                  


Asp Arg Leu Ser Leu Arg Arg Asp Arg Ser Thr Gly Thr Val Phe Met 
65                  70                  75                  80  


Glu Leu Arg Gly Leu Arg Leu Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Leu Gly Glu Val Ala Pro Ala Tyr Leu Tyr Gly Ile Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Ser Thr Val Ile Val Thr Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly 
    


<210>  14
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Leu Asn Phe Val 
            20                  25                  30          


Val Trp Tyr Gln Gln Lys Gly Gly Gln Ala Pro Arg Leu Leu Ile His 
        35                  40                  45              


Gly Pro Thr Asp Arg Ala Pro Gly Val Pro Asp Arg Phe Ser Ala Arg 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Ser Leu Val Ile Ser Ser Val Glu Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Leu Tyr Tyr Cys Gln Glu Tyr Ser Ser Thr Pro Tyr Asn 
                85                  90                  95      


Phe Gly Pro Gly Thr Arg Val Asp Arg Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120             


<210>  15
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Val Gln Leu Glu Gln Ser Gly Thr Ala Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Gln Ala Ser Gly Tyr Asn Phe Val Lys Tyr 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Lys Pro Gly Leu Gly Phe Glu Trp Val 
        35                  40                  45              


Gly Met Ile Asp Pro Tyr Arg Gly Arg Pro Trp Ser Ala His Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Ser Leu Ser Arg Asp Thr Ser Met Glu Ile Leu Tyr 
65                  70                  75                  80  


Met Thr Leu Thr Ser Leu Lys Ser Asp Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Glu Ala Ala Ser Asp Ser His Ser Arg Pro Ile Met Phe 
            100                 105                 110         


Asp His 
        


<210>  16
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Val Gln Leu Glu Gln Ser Gly Thr Ala Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Gln Ala Ser Gly Tyr Asn Phe Val Lys Tyr 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Lys Pro Gly Leu Gly Phe Glu Trp Val 
        35                  40                  45              


Gly Met Ile Asp Pro Tyr Arg Gly Arg Pro Trp Ser Ala His Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Ser Leu Ser Arg Asp Thr Ser Met Glu Ile Leu Tyr 
65                  70                  75                  80  


Met Thr Leu Thr Ser Leu Lys Ser Asp Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Glu Ala Ala Ser Asp Ser His Ser Arg Pro Ile Met Phe 
            100                 105                 110         


Asp His 
        


<210>  17
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Val Gln Leu Glu Gln Ser Gly Thr Ala Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Gln Ala Ser Gly Tyr Asn Phe Val Lys Tyr 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Lys Pro Gly Leu Gly Phe Glu Trp Val 
        35                  40                  45              


Gly Met Ile Asp Pro Tyr Arg Gly Arg Pro Trp Ser Ala His Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Ser Leu Ser Arg Asp Thr Ser Met Glu Ile Leu Tyr 
65                  70                  75                  80  


Met Thr Leu Thr Ser Leu Lys Ser Asp Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Glu Ala Ala Ser Asp Ser His Ser Arg Pro Ile Met Phe 
            100                 105                 110         


Asp His 
        


<210>  18
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Val Gln Leu Glu Gln Ser Gly Thr Ala Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Gln Ala Ser Gly Tyr Asn Phe Val Lys Tyr 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Lys Pro Gly Leu Gly Phe Glu Trp Val 
        35                  40                  45              


Gly Met Ile Asp Pro Tyr Arg Gly Arg Pro Trp Ser Ala His Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Ser Leu Ser Arg Asp Thr Ser Met Glu Ile Leu Tyr 
65                  70                  75                  80  


Met Thr Leu Thr Ser Leu Lys Ser Asp Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Glu Ala Ala Ser Asp Ser His Ser Arg Pro Ile Met Phe 
            100                 105                 110         


Asp His 
        


<210>  19
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Ile His Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Tyr Gly Val Asn Thr Phe Gly Leu 
            20                  25                  30          


Tyr Ala Val Asn Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Tyr 
        35                  40                  45              


Ile Gly Gln Ile Trp Arg Trp Lys Ser Ser Ala Ser His His Phe Arg 
    50                  55                  60                  


Gly Arg Val Leu Ile Ser Ala Val Asp Leu Thr Gly Ser Ser Pro Pro 
65                  70                  75                  80  


Ile Ser Ser Leu Glu Ile Lys Asn Leu Thr Ser Asp Asp Thr Ala Val 
                85                  90                  95      


Tyr Phe Cys Thr Thr Thr Ser Thr Tyr Asp Lys Trp Ser Gly Leu His 
            100                 105                 110         


His Asp Gly Val Met Ala Phe Ser Ser Trp Gly Gln Gly Thr Leu Ile 
        115                 120                 125             


Ser Val Ser Ala Ala Ser Thr Lys Gly 
    130                 135         


<210>  20
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ala Ala Ser Ile Gly 
1               5                   10                  15      


Gly Thr Val Arg Val Ser Cys Arg Ala Ser Gln Ser Ile Thr Gly Asn 
            20                  25                  30          


Trp Val Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Gly Ala Ala Leu Leu Gly Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ala Ala Gly Thr Asp Phe Thr Leu Thr Ile Gly Asn Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Phe Gly Thr Phe Tyr Cys Gln Gln Tyr Asp Thr Tyr Pro 
                85                  90                  95      


Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125 


<210>  21
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Leu Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Asn Val Ser Gly Ala Phe Ile Ala Asp His 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Leu Pro Leu Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val His Asp Ser Gly Asp Ile Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Asn Arg Val His Leu Ser Leu Asp Lys Ser Thr Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Met Ala Val Thr Ala Gly Asp Ser Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Thr Lys His Gly Arg Arg Ile Tyr Gly Val Val Ala Phe Gly Glu 
            100                 105                 110         


Trp Phe Thr Tyr Phe Tyr Met Asp Val Trp Gly Arg Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  22
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Asn Val Ser Gly Thr Leu Val Arg Asp Asn 
            20                  25                  30          


Tyr Trp Ser Trp Met Arg Gln Pro Leu Gly Lys Gln Pro Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val His Asp Ser Gly Asp Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val His Leu Ser Leu Asp Lys Ser Asn Asn Leu Val Ser Leu 
65                  70                  75                  80  


Arg Leu Thr Ala Val Thr Ala Ala Asp Ser Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Thr Lys His Gly Arg Arg Ile Tyr Gly Ile Val Ala Phe Asn Glu 
            100                 105                 110         


Trp Phe Thr Tyr Phe Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  23
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Ala Ser Ile Ser Asp Ser 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Arg Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val His Lys Ser Gly Asp Thr Asn Tyr Ser Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Asn Leu Ser Leu Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Val Ala Ala Thr Ala Ala Asp Ser Gly Lys Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Leu His Gly Arg Arg Ile Tyr Gly Ile Val Ala Phe Asn Glu 
            100                 105                 110         


Trp Phe Thr Tyr Phe Tyr Met Asp Val Trp Gly Asn Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  24
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Pro Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Ala Ser Val Asn Asp Ala 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Arg Pro Glu Trp Val 
        35                  40                  45              


Gly Tyr Val His His Ser Gly Asp Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Arg Arg Val Thr Phe Ser Leu Asp Thr Ala Lys Asn Glu Val Ser Leu 
65                  70                  75                  80  


Lys Leu Val Ala Leu Thr Ala Ala Asp Ser Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ala Leu His Gly Lys Arg Ile Tyr Gly Ile Val Ala Leu Gly Glu 
            100                 105                 110         


Leu Phe Thr Tyr Phe Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  25
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Pro Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Ala Ser Ile Asn Asp Ala 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Arg Pro Glu Trp Val 
        35                  40                  45              


Gly Tyr Val His His Ser Gly Asp Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Arg Arg Val Thr Phe Ser Leu Asp Thr Ala Lys Asn Glu Val Ser Leu 
65                  70                  75                  80  


Lys Leu Val Asp Leu Thr Ala Ala Asp Ser Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ala Leu His Gly Lys Arg Ile Tyr Gly Ile Val Ala Leu Gly Glu 
            100                 105                 110         


Leu Phe Thr Tyr Phe Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  26
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Pro Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Ala Ser Ile Asn Asp Ala 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Arg Pro Glu Trp Val 
        35                  40                  45              


Gly Tyr Val His His Ser Gly Asp Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Arg Arg Val Ser Phe Ser Leu Asp Thr Ala Lys Asn Glu Val Ser Leu 
65                  70                  75                  80  


Lys Leu Val Asp Leu Thr Ala Ala Asp Ser Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ala Leu His Gly Lys Arg Ile Tyr Gly Ile Val Ala Leu Gly Glu 
            100                 105                 110         


Leu Phe Thr Tyr Phe Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  27
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Thr Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Asn Gly Ser Val Ser Gly Arg 
            20                  25                  30          


Phe Trp Ser Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Ser Asp Thr Asp Arg Ser Glu Tyr Ser Pro Ser Leu Arg 
    50                  55                  60                  


Ser Arg Leu Thr Leu Ser Leu Asp Ala Ser Arg Asn Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Lys Ser Val Thr Ala Ala Asp Ser Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gln Gln Gly Lys Arg Ile Tyr Gly Ile Val Ser Phe Gly Glu 
            100                 105                 110         


Phe Phe Tyr Tyr Tyr Tyr Met Asp Ala Trp Gly Lys Gly Thr Ala Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  28
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Asn Gly Ser Val Ser Gly Arg 
            20                  25                  30          


Phe Trp Ser Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Ser Asp Thr Glu Lys Ser Asn Tyr Asn Pro Ser Leu Arg 
    50                  55                  60                  


Ser Arg Leu Thr Leu Ser Val Asp Ala Ser Lys Asn Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Ala Ala Asp Ser Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Gln Gln Gly Lys Arg Ile Tyr Gly Val Val Ser Phe Gly Glu 
            100                 105                 110         


Phe Phe His Tyr Tyr Tyr Met Asp Ala Trp Gly Lys Gly Thr Ala Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  29
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Ser Val Ser Gly Asp Ser Met Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Asp Arg Glu Ser Ala Thr Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  


Ser Arg Val Val Ile Ser Arg Asp Thr Ser Thr Asn Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Pro Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Ala Arg Arg Gly Gln Arg Ile Tyr Gly Val Val Ser Phe Gly Glu 
            100                 105                 110         


Phe Phe Tyr Tyr Tyr Ser Met Asp Val Trp Gly Arg Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  30
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Ser Val Ser Gly Asp Ser Met Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Asp Arg Ala Ser Ala Thr Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  


Ser Arg Val Val Ile Ser Arg Asp Thr Ser Lys Asn Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Pro Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Ala Arg Arg Gly Gln Arg Ile Tyr Gly Val Val Ser Phe Gly Glu 
            100                 105                 110         


Phe Phe Tyr Tyr Tyr Ser Met Asp Val Trp Gly Lys Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  31
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Ser Val Ser Gly Asp Ser Met Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Asp Arg Glu Ser Ala Thr Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  


Ser Arg Val Val Ile Ser Arg Asp Thr Ser Lys Asn Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Pro Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Ala Arg Arg Gly Gln Arg Ile Tyr Gly Val Val Ser Phe Gly Glu 
            100                 105                 110         


Phe Phe Tyr Tyr Tyr Ser Met Asp Val Trp Gly Lys Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  32
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Ser Val Ser Gly Asp Ser Met Asn Asn Ser 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Lys Ser Glu Ser Ala Asn Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  


Ser Arg Val Val Ile Ser Arg Asp Thr Ser Lys Asn Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Pro Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Ala Arg His Gly Gln Arg Ile Tyr Gly Val Val Ser Phe Gly Glu 
            100                 105                 110         


Phe Phe Thr Tyr Tyr Ser Met Asp Val Trp Gly Lys Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  33
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  33

Ser Ser Met Ser Val Ser Pro Gly Glu Thr Ala Lys Ile Thr Cys Gly 
1               5                   10                  15      


Glu Lys Ser Ile Gly Ser Arg Ala Val Gln Trp Tyr Gln Lys Lys Pro 
            20                  25                  30          


Gly Gln Pro Pro Ser Leu Ile Ile Tyr Asn Asn Gln Asp Arg Pro Ser 
        35                  40                  45              


Gly Val Pro Glu Arg Phe Ser Ala Ser Pro Asp Ile Glu Phe Gly Thr 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Asn Val Glu Ala Gly Asp Glu Ala Asp 
65                  70                  75                  80  


Tyr Tyr Cys His Ile Tyr Asp Ala Arg Arg Pro Thr Asn Trp Val Phe 
                85                  90                  95      


Asp Arg Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  34
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  34

Ser Ser Met Ser Val Ser Pro Gly Glu Thr Ala Lys Ile Ser Cys Gly 
1               5                   10                  15      


Lys Glu Ser Ile Gly Ser Arg Ala Val Gln Trp Tyr Gln Gln Lys Ser 
            20                  25                  30          


Gly Gln Pro Pro Ser Leu Ile Ile Tyr Asn Asn Gln Asp Arg Pro Ser 
        35                  40                  45              


Gly Val Pro Glu Arg Phe Ser Ala Thr Pro Asp Phe Gly Ala Gly Thr 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Asn Val Glu Ala Asp Asp Glu Ala Asp 
65                  70                  75                  80  


Tyr Tyr Cys His Ile Tyr Asp Ala Arg Gly Gly Thr Asn Trp Val Phe 
                85                  90                  95      


Asp Arg Gly Ala Thr Leu Thr Val Leu 
            100                 105 


<210>  35
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Asp Ile Ser Val Ala Pro Gly Glu Thr Ala Arg Ile Ser Cys Gly 
1               5                   10                  15      


Glu Lys Ser Leu Gly Ser Arg Ala Val Gln Trp Tyr Gln His Arg Ala 
            20                  25                  30          


Gly Gln Ala Pro Ser Leu Ile Ile Tyr Asn Asn Gln Asp Arg Pro Ser 
        35                  40                  45              


Gly Ile Pro Glu Arg Phe Ser Gly Ser Pro Asp Ser Pro Phe Gly Thr 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Ser Val Glu Ala Gly Asp Glu Ala Asp 
65                  70                  75                  80  


Tyr Tyr Cys His Ile Trp Asp Ser Arg Val Pro Thr Lys Trp Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  36
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Phe Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly 
1               5                   10                  15      


Glu Glu Ser Leu Gly Ser Arg Ser Val Ile Trp Tyr Gln Gln Arg Pro 
            20                  25                  30          


Gly Gln Ala Pro Ser Leu Ile Met Tyr Asn Asn His Asp Arg Pro Ser 
        35                  40                  45              


Gly Ile Pro Glu Arg Phe Ser Gly Ser Pro Gly Ser Thr Phe Gly Thr 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Ser Val Glu Ala Gly Asp Glu Ala Asp 
65                  70                  75                  80  


Tyr Tyr Cys His Ile Trp Asp Ser Arg Arg Pro Thr Asn Trp Val Phe 
                85                  90                  95      


Gly Glu Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  37
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  37

Ser Phe Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly 
1               5                   10                  15      


Glu Glu Ser Leu Gly Ser Arg Ser Val Ile Trp Tyr Gln Gln Arg Pro 
            20                  25                  30          


Gly Gln Ala Pro Ser Leu Ile Ile Tyr Asn Asn Asn Asp Arg Pro Ser 
        35                  40                  45              


Gly Ile Pro Glu Arg Phe Ser Gly Ser Pro Gly Ser Thr Phe Gly Thr 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Ser Val Glu Ala Gly Asp Glu Ala Asp 
65                  70                  75                  80  


Tyr Tyr Cys His Ile Trp Asp Ser Arg Arg Pro Thr Asn Trp Val Phe 
                85                  90                  95      


Gly Glu Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  38
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  38

Ser Phe Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly 
1               5                   10                  15      


Glu Glu Ser Leu Gly Ser Arg Ser Val Ile Trp Tyr Gln Gln Arg Pro 
            20                  25                  30          


Gly Gln Ala Pro Ser Leu Ile Ile Tyr Asn Asn Asn Asp Arg Pro Ser 
        35                  40                  45              


Gly Ile Pro Glu Arg Phe Ser Gly Ser Pro Gly Ser Thr Phe Gly Thr 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Ser Val Glu Ala Gly Asp Glu Ala Asp 
65                  70                  75                  80  


Tyr Tyr Cys His Ile Trp Asp Ser Arg Arg Pro Thr Asn Trp Val Phe 
                85                  90                  95      


Gly Glu Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  39
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  39

Ser Tyr Val Arg Pro Leu Ser Val Ala Leu Gly Glu Thr Ala Ser Ile 
1               5                   10                  15      


Ser Cys Gly Arg Gln Ala Leu Gly Ser Arg Ala Val Gln Trp Tyr Gln 
            20                  25                  30          


His Arg Pro Gly Gln Ala Pro Ile Leu Leu Ile Tyr Asn Asn Gln Asp 
        35                  40                  45              


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Thr Pro Asp Ile Asn 
    50                  55                  60                  


Phe Gly Thr Arg Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys His Met Trp Asp Ser Arg Ser Gly Phe Ser 
                85                  90                  95      


Trp Ser Phe Gly Gly Ala Thr Arg Leu Thr Val Leu 
            100                 105             


<210>  40
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  40

Ser Tyr Val Arg Pro Leu Ser Val Ala Leu Gly Glu Thr Ala Arg Ile 
1               5                   10                  15      


Ser Cys Gly Arg Gln Ala Leu Gly Ser Arg Ala Val Gln Trp Tyr Gln 
            20                  25                  30          


His Arg Pro Gly Gln Ala Pro Ile Leu Leu Ile Tyr Asn Asn Gln Asp 
        35                  40                  45              


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Thr Pro Asp Ile Asn 
    50                  55                  60                  


Phe Gly Thr Arg Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys His Met Trp Asp Ser Arg Ser Gly Phe Ser 
                85                  90                  95      


Trp Ser Phe Gly Gly Ala Thr Arg Leu Thr Val Leu 
            100                 105             


<210>  41
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  41

Ser Tyr Val Arg Pro Leu Ser Val Ala Leu Gly Glu Thr Ala Arg Ile 
1               5                   10                  15      


Ser Cys Gly Arg Gln Ala Leu Gly Ser Arg Ala Val Gln Trp Tyr Gln 
            20                  25                  30          


His Arg Pro Gly Gln Ala Pro Ile Leu Leu Ile Tyr Asn Asn Gln Asp 
        35                  40                  45              


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Thr Pro Asp Ile Asn 
    50                  55                  60                  


Phe Gly Thr Arg Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys His Met Trp Asp Ser Arg Ser Gly Phe Ser 
                85                  90                  95      


Trp Ser Phe Gly Gly Ala Thr Arg Leu Thr Val Leu 
            100                 105             


<210>  42
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  42

Ser Ser Leu Pro Leu Ser Val Ala Pro Gly Ala Thr Ala Lys Ile Ala 
1               5                   10                  15      


Cys Gly Glu Lys Ser Phe Ala Ser Arg Ala Val Gln Trp Tyr Gln Gln 
            20                  25                  30          


Lys Pro Gly Gln Ala Pro Val Leu Ile Ile Tyr Asn Asn Gln Asp Arg 
        35                  40                  45              


Pro Ala Gly Val Ser Glu Arg Phe Ser Gly Thr Pro Asp Val Gly Phe 
    50                  55                  60                  


Gly Ser Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys His Lys Trp Asp Ser Arg Ser Pro Leu Ser Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105         


<210>  43
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  43

Ser Ser Leu Pro Leu Ser Leu Ala Pro Gly Ala Thr Ala Lys Ile Pro 
1               5                   10                  15      


Cys Gly Glu Lys Ser Arg Gly Ser Arg Ala Val Gln Trp Tyr Gln Gln 
            20                  25                  30          


Lys Pro Gly Gln Ala Pro Thr Leu Ile Ile Tyr Asn Asn Gln Asp Arg 
        35                  40                  45              


Pro Ala Gly Val Ser Glu Arg Tyr Ser Gly Asn Pro Asp Val Ala Ile 
    50                  55                  60                  


Gly Val Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu 
65                  70                  75                  80  


Ala Glu Tyr Tyr Cys His Tyr Trp Asp Ser Arg Ser Pro Ile Ser Trp 
                85                  90                  95      


Val Phe Gly Gly Trp Thr Gln Leu Thr Val Leu 
            100                 105         


<210>  44
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  syntheszed

<400>  44
cccaccaaca rgcrgcct                                                     18


<210>  45
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  45
taatggcagc aatttcacca                                                   20


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  46
gaatgccaaa ttcctgcttg a                                                 21


<210>  47
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  47
ggcttaggca tctcctatgg caggaagaa                                         29


<210>  48
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  48
ggtgtgtagt tctgccaatc agggaagwag ccttgtg                                37


<210>  49
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  49
tagaaagagc agaagacagt ggcaatga                                          28


<210>  50
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  50
tcatcaatgg tggtgatgat gatgtttttc tctctgcacc actcttct                    48


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  51
gttggaccaa gctatgcagg t                                                 21


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  52
agaagcgttt ggcaatgtgc                                                   20


<210>  53
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthesized

<400>  53
ttgggatgac gcactgctgc atcaacccca                                        30


<210>  54
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  54

Thr Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr 
1               5                   10                  15      


Gly Val His Ser Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Leu Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe His Lys Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Leu Ile Ser Asp Asp Gly Met Arg Lys Tyr His 
65                  70                  75                  80  


Ser Asp Ser Met Trp Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Phe Ser Ser Leu Lys Val Glu Asp Thr Ala 
            100                 105                 110         


Met Phe Phe Cys Ala Arg Glu Ala Gly Gly Pro Ile Trp His Asp Asp 
        115                 120                 125             


Val Lys Tyr Tyr Asp Phe Asn Asp Gly Tyr Tyr Asn Tyr His Tyr Met 
    130                 135                 140                 


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
145                 150                 155                 160 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                165                 170                 175     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            180                 185                 190         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        195                 200                 205             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    210                 215                 220                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
225                 230                 235                 240 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                245                 250                 255     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            260                 265                 270         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        275                 280                 285             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    290                 295                 300                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
305                 310                 315                 320 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                325                 330                 335     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            340                 345                 350         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        355                 360                 365             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    370                 375                 380                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
385                 390                 395                 400 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                405                 410                 415     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            420                 425                 430         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        435                 440                 445             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    450                 455                 460                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
465                 470                 475                 480 


Leu Ser Leu Ser Pro Gly Lys 
                485         


<210>  55
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  55

Thr Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr 
1               5                   10                  15      


Gly Ser Val Thr Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          


Ser Pro Gly Gln Thr Ile Thr Ile Ser Cys Asn Gly Thr Ser Ser Asp 
        35                  40                  45              


Val Gly Gly Phe Asp Ser Val Ser Trp Tyr Gln Gln Ser Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Val Met Val Phe Asp Val Ser His Arg Pro Ser Gly Ile 
65                  70                  75                  80  


Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      


Ile Ser Gly Leu His Ile Glu Asp Glu Gly Asp Tyr Phe Cys Ser Ser 
            100                 105                 110         


Leu Thr Asp Arg Ser His Arg Ile Phe Gly Gly Gly Thr Lys Val Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


