                         SEQUENCE LISTING

<110>  The University of Notre Dame du Lac
 
<120>  MOLECULAR CONSTRUCTS AND USES THEREOF

<130>  520837-39

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Tyr 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Phe Gly Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Thr Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Gly Pro Arg Ile Arg Leu Leu Cys 
    290                 295                 300                 


Cys Val Ala Phe Ser Leu Leu Trp Ala Gly Pro Val Ile Ala Gly Ile 
305                 310                 315                 320 


Thr Gln Ala Pro Thr Ser Gln Ile Leu Ala Ala Gly Arg Arg Met Thr 
                325                 330                 335     


Leu Arg Cys Thr Gln Asp Met Arg His Asn Ala Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Leu Gly Leu Gly Leu Arg Leu Ile His Tyr Ser Asn Thr Ala 
        355                 360                 365             


Gly Thr Thr Gly Lys Gly Glu Val Pro Asp Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Ala Asn Thr Asp Asp Phe Pro Leu Thr Leu Ala Ser Ala Val Pro Ser 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Trp Ser Phe Gly Thr Glu 
                405                 410                 415     


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn 
            420                 425                 430         


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
        435                 440                 445             


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
                485                 490                 495     


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
    530                 535                 540                 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe Glu Phe Lys 
        595                 600                 605             


<210>  2
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Tyr 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Phe Gly Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Thr Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Gly Pro Arg Ile Arg Leu Leu Cys 
    290                 295                 300                 


Cys Val Ala Phe Ser Leu Leu Trp Ala Gly Pro Val Ile Ala Gly Ile 
305                 310                 315                 320 


Thr Gln Ala Pro Thr Ser Gln Ile Leu Ala Ala Gly Arg Arg Met Thr 
                325                 330                 335     


Leu Arg Cys Thr Gln Asp Met Arg His Asn Ala Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Leu Gly Leu Gly Leu Arg Leu Ile His Tyr Ser Asn Thr Ala 
        355                 360                 365             


Gly Thr Thr Gly Lys Gly Glu Val Pro Asp Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Ala Asn Thr Asp Asp Phe Pro Leu Thr Leu Ala Ser Ala Val Pro Ser 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Leu Ser Phe Gly Thr Glu 
                405                 410                 415     


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn 
            420                 425                 430         


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
        435                 440                 445             


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
                485                 490                 495     


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
    530                 535                 540                 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe Glu Phe Lys 
        595                 600                 605             


<210>  3
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Phe Gly Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Thr Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Gly Pro Arg Ile Arg Leu Leu Cys 
    290                 295                 300                 


Cys Val Ala Phe Ser Leu Leu Trp Ala Gly Pro Val Ile Ala Gly Ile 
305                 310                 315                 320 


Thr Gln Ala Pro Thr Ser Gln Ile Leu Ala Ala Gly Arg Arg Met Thr 
                325                 330                 335     


Leu Arg Cys Thr Gln Asp Met Arg His Asn Ala Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Leu Gly Leu Gly Leu Arg Leu Ile His Tyr Ser Asn Thr Ala 
        355                 360                 365             


Gly Thr Thr Gly Lys Gly Glu Val Pro Asp Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Ala Asn Thr Asp Asp Phe Pro Leu Thr Leu Ala Ser Ala Val Pro Ser 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Trp Ser Phe Gly Thr Glu 
                405                 410                 415     


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn 
            420                 425                 430         


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
        435                 440                 445             


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
                485                 490                 495     


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
    530                 535                 540                 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe Glu Phe Lys 
        595                 600                 605             


<210>  4
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Phe Gly Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Thr Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Gly Pro Arg Ile Arg Leu Leu Cys 
    290                 295                 300                 


Cys Val Ala Phe Ser Leu Leu Trp Ala Gly Pro Val Ile Ala Gly Ile 
305                 310                 315                 320 


Thr Gln Ala Pro Thr Ser Gln Ile Leu Ala Ala Gly Arg Arg Met Thr 
                325                 330                 335     


Leu Arg Cys Thr Gln Asp Met Arg His Asn Ala Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Leu Gly Leu Gly Leu Arg Leu Ile His Tyr Ser Asn Thr Ala 
        355                 360                 365             


Gly Thr Thr Gly Lys Gly Glu Val Pro Asp Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Ala Asn Thr Asp Asp Phe Pro Leu Thr Leu Ala Ser Ala Val Pro Ser 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Leu Ser Phe Gly Thr Glu 
                405                 410                 415     


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn 
            420                 425                 430         


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
        435                 440                 445             


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
                485                 490                 495     


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
    530                 535                 540                 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe Glu Phe Lys 
        595                 600                 605             


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   


<210>  6
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Tyr 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Val Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Phe Gly Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Thr Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Gly Pro Arg Ile Arg Leu Leu Cys 
    290                 295                 300                 


Cys Val Ala Phe Ser Leu Leu Trp Ala Gly Pro Val Ile Ala Gly Ile 
305                 310                 315                 320 


Thr Gln Ala Pro Thr Ser Gln Ile Leu Ala Ala Gly Arg Arg Met Thr 
                325                 330                 335     


Leu Arg Cys Thr Gln Asp Met Arg His Asn Ala Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Leu Gly Leu Gly Leu Arg Leu Ile His Tyr Ser Asn Thr Ala 
        355                 360                 365             


Gly Thr Thr Gly Lys Gly Glu Val Pro Asp Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Ala Asn Thr Asp Asp Phe Pro Leu Thr Leu Ala Ser Ala Val Pro Ser 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Leu Ser Phe Gly Thr Glu 
                405                 410                 415     


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn 
            420                 425                 430         


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
        435                 440                 445             


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
                485                 490                 495     


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
    530                 535                 540                 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe Glu Phe Lys 
        595                 600                 605             


<210>  7
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Leu Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  8
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Tyr 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Ala Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Phe Gly Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Thr Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Gly Pro Arg Ile Arg Leu Leu Cys 
    290                 295                 300                 


Cys Val Ala Phe Ser Leu Leu Trp Ala Gly Pro Val Ile Ala Gly Ile 
305                 310                 315                 320 


Thr Gln Ala Pro Thr Ser Gln Ile Leu Ala Ala Gly Arg Arg Met Thr 
                325                 330                 335     


Leu Arg Cys Thr Gln Asp Met Arg His Asn Ala Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Leu Gly Leu Gly Leu Arg Leu Ile His Tyr Ser Asn Thr Ala 
        355                 360                 365             


Gly Thr Thr Gly Lys Gly Glu Val Pro Asp Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Ala Asn Thr Asp Asp Phe Pro Leu Thr Leu Ala Ser Ala Val Pro Ser 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Trp Ser Phe Gly Thr Glu 
                405                 410                 415     


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn 
            420                 425                 430         


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
        435                 440                 445             


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
                485                 490                 495     


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
    530                 535                 540                 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe Glu Phe Lys 
        595                 600                 605             


<210>  9
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Tyr 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Val Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Phe Gly Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Thr Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Gly Pro Arg Ile Arg Leu Leu Cys 
    290                 295                 300                 


Cys Val Ala Phe Ser Leu Leu Trp Ala Gly Pro Val Ile Ala Gly Ile 
305                 310                 315                 320 


Thr Gln Ala Pro Thr Ser Gln Ile Leu Ala Ala Gly Arg Arg Met Thr 
                325                 330                 335     


Leu Arg Cys Thr Gln Asp Met Arg His Asn Ala Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Leu Gly Leu Gly Leu Arg Leu Ile His Tyr Ser Asn Thr Ala 
        355                 360                 365             


Gly Thr Thr Gly Lys Gly Glu Val Pro Asp Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Ala Asn Thr Asp Asp Phe Pro Leu Thr Leu Ala Ser Ala Val Pro Ser 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Trp Ser Phe Gly Thr Glu 
                405                 410                 415     


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn 
            420                 425                 430         


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
        435                 440                 445             


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
                485                 490                 495     


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
    530                 535                 540                 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe Glu Phe Lys 
        595                 600                 605             


<210>  10
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Tyr 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Phe Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Phe Gly Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Thr Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Gly Pro Arg Ile Arg Leu Leu Cys 
    290                 295                 300                 


Cys Val Ala Phe Ser Leu Leu Trp Ala Gly Pro Val Ile Ala Gly Ile 
305                 310                 315                 320 


Thr Gln Ala Pro Thr Ser Gln Ile Leu Ala Ala Gly Arg Arg Met Thr 
                325                 330                 335     


Leu Arg Cys Thr Gln Asp Met Arg His Asn Ala Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Leu Gly Leu Gly Leu Arg Leu Ile His Tyr Ser Asn Thr Ala 
        355                 360                 365             


Gly Thr Thr Gly Lys Gly Glu Val Pro Asp Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Ala Asn Thr Asp Asp Phe Pro Leu Thr Leu Ala Ser Ala Val Pro Ser 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Trp Ser Phe Gly Thr Glu 
                405                 410                 415     


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn 
            420                 425                 430         


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
        435                 440                 445             


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
                485                 490                 495     


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
    530                 535                 540                 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe Glu Phe Lys 
        595                 600                 605             


<210>  11
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Tyr 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Trp Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Phe Gly Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Thr Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Gly Pro Arg Ile Arg Leu Leu Cys 
    290                 295                 300                 


Cys Val Ala Phe Ser Leu Leu Trp Ala Gly Pro Val Ile Ala Gly Ile 
305                 310                 315                 320 


Thr Gln Ala Pro Thr Ser Gln Ile Leu Ala Ala Gly Arg Arg Met Thr 
                325                 330                 335     


Leu Arg Cys Thr Gln Asp Met Arg His Asn Ala Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Leu Gly Leu Gly Leu Arg Leu Ile His Tyr Ser Asn Thr Ala 
        355                 360                 365             


Gly Thr Thr Gly Lys Gly Glu Val Pro Asp Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Ala Asn Thr Asp Asp Phe Pro Leu Thr Leu Ala Ser Ala Val Pro Ser 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Trp Ser Phe Gly Thr Glu 
                405                 410                 415     


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn 
            420                 425                 430         


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
        435                 440                 445             


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
                485                 490                 495     


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
    530                 535                 540                 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe Glu Phe Lys 
        595                 600                 605             


<210>  12
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  13
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Phe Gly Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Thr Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Gly Pro Arg Ile Arg Leu Leu Cys 
    290                 295                 300                 


Cys Val Ala Phe Ser Leu Leu Trp Ala Gly Pro Val Ile Ala Gly Ile 
305                 310                 315                 320 


Thr Gln Ala Pro Thr Ser Gln Ile Leu Ala Ala Gly Arg Arg Met Thr 
                325                 330                 335     


Leu Arg Cys Thr Gln Asp Met Arg His Asn Ala Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Leu Gly Leu Gly Leu Arg Leu Ile His Tyr Ser Asn Thr Ala 
        355                 360                 365             


Gly Thr Thr Gly Lys Gly Glu Val Pro Asp Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Ala Asn Thr Asp Asp Phe Pro Leu Thr Leu Ala Ser Ala Val Pro Ser 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Leu Ser Phe Gly Thr Glu 
                405                 410                 415     


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn 
            420                 425                 430         


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
        435                 440                 445             


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
                485                 490                 495     


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
    530                 535                 540                 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
        595                 600                 605 


<210>  14
<211>  1859
<212>  DNA
<213>  Homo sapiens

<400>  14
aaagcggccg ctacgtagtc gactgcacct agaatatgaa atccttgaga gttttactag       60

tgatcctgtg gcttcagttg agctgggttt ggagccaaca gaaggaggtg gagcagaact      120

ctggacccct cagtgttcca gagggagcca ttgcctctct caactgcact tacagtgacc      180

gaggttccca gtccttcttc tggtacagac aatattctgg gaaaagccct gagttgataa      240

tgttcatata ctccaatggt gacaaagaag atggaaggtt tacagcacag ctcaataaag      300

ccagccagta tgtttctctg ctcatcagag actcccagcc cagtgattca gccacctacc      360

tctgtgccgt gaacttcgga ggaggaaagc ttatcttcgg acagggaacg gagctatctg      420

tgaaacccaa tatccagaac cctgaccctg ccgtgtacca gctgagagac tctaaatcca      480

gtgacaagtc tgtctgccta ttcaccgatt ttgattctca aacaaatgtg tcacaaagta      540

aggattctga tgtgtatatc acagacaaaa ctgtgctaga catgaggtct atggacttca      600

agagcaacag tgctgtggcc tggagcaaca aatctgactt tgcatgtgca aacgccttca      660

acaacagcat tattccagaa gacaccttct tccccagccc agaaagttcc tgtgatgtca      720

agctggtcga gaaaagcttt gaaacagata cgaacctaaa ctttcaaaac ctgtcagtga      780

ttgggttccg aatcctcctc ctgaaagtgg ccgggtttaa tctgctcatg acgctgcggc      840

tgtggtccag caccggtggg tccggagcca cgaacttctc tctgttaaag caagcaggag      900

acgtggagga gaaccccggt cctgggccca gaatcaggct cctgtgctgt gtggcctttt      960

ctctcctgtg ggcaggtcca gtgattgctg ggatcaccca ggcaccaaca tctcagatcc     1020

tggcagcagg acggcgcatg acactgagat gtacccagga tatgagacat aatgccatgt     1080

actggtatag acaagatcta ggactggggc taaggctcat ccattattca aatactgcag     1140

gtaccactgg caaaggagaa gtccctgatg gttatagtgt ctccagagca aacacagatg     1200

atttccccct cacgttggcg tctgctgtac cctctcagac atctgtgtac ttctgtgcca     1260

gcagtttgtc cttcggaact gaagctttct ttggacaagg caccagactc acagttgtag     1320

aggacctgaa caaggtgttc ccacccgagg tcgctgtgtt tgagccatca gaagcagaga     1380

tctcccacac ccaaaaggcc acactggtgt gcctggccac aggcttcttc cccgaccacg     1440

tggagctgag ctggtgggtg aatgggaagg aggtgcacag tggggtcagc acggacccgc     1500

agcccctcaa ggagcagccc gccctcaatg actccagata ctgcctgagc agccgcctga     1560

gggtctcggc caccttctgg cagaaccccc gcaaccactt ccgctgtcaa gtccagttct     1620

acgggctctc ggagaatgac gagtggaccc aggatagggc caaacccgtc acccagatcg     1680

tcagcgccga ggcctggggt agagcagact gtggctttac ctcggtgtcc taccagcaag     1740

gggtcctgtc tgccaccatc ctctatgaga tcctgctagg gaaggccacc ctgtatgctg     1800

tgctggtcag cgcccttgtg ttgatggcca tggtcaagag aaaggatttc gaattcaaa      1859


<210>  15
<211>  586
<212>  PRT
<213>  Synthetic Sequence


<220>
<221>  featureMiscellaneous
<222>  (50)..(50)
<223>  Xaa is any amino acid except tyrosine

<400>  15

Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly Ala 
1               5                   10                  15      


Ile Ala Ser Leu Asn Cys Thr Tyr Ser Tyr Arg Gly Ser Gln Ser Phe 
            20                  25                  30          


Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met Phe 
        35                  40                  45              


Ile Xaa Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu 
    50                  55                  60                  


Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln Pro 
65                  70                  75                  80  


Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Phe Gly Gly Gly Lys 
                85                  90                  95      


Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser Val Lys Pro Asn Ile Gln 
            100                 105                 110         


Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp 
        115                 120                 125             


Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser 
    130                 135                 140                 


Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp 
145                 150                 155                 160 


Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn 
                165                 170                 175     


Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro 
            180                 185                 190         


Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu 
        195                 200                 205             


Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu 
    210                 215                 220                 


Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
225                 230                 235                 240 


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Thr Gly Gly Ser Gly Ala 
                245                 250                 255     


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
            260                 265                 270         


Gly Pro Gly Pro Arg Ile Arg Leu Leu Cys Cys Val Ala Phe Ser Leu 
        275                 280                 285             


Leu Trp Ala Gly Pro Val Ile Ala Gly Ile Thr Gln Ala Pro Thr Ser 
    290                 295                 300                 


Gln Ile Leu Ala Ala Gly Arg Arg Met Thr Leu Arg Cys Thr Gln Asp 
305                 310                 315                 320 


Met Arg His Asn Ala Met Tyr Trp Tyr Arg Gln Asp Leu Gly Leu Gly 
                325                 330                 335     


Leu Arg Leu Ile His Tyr Ser Asn Thr Ala Gly Thr Thr Gly Lys Gly 
            340                 345                 350         


Glu Val Pro Asp Gly Tyr Ser Val Ser Arg Ala Asn Thr Asp Asp Phe 
        355                 360                 365             


Pro Leu Thr Leu Ala Ser Ala Val Pro Ser Gln Thr Ser Val Tyr Phe 
    370                 375                 380                 


Cys Ala Ser Ser Trp Ser Phe Gly Thr Glu Ala Phe Phe Gly Gln Gly 
385                 390                 395                 400 


Thr Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu 
                405                 410                 415     


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
            420                 425                 430         


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu 
        435                 440                 445             


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
    450                 455                 460                 


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
465                 470                 475                 480 


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
                485                 490                 495     


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
            500                 505                 510         


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
        515                 520                 525             


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr 
    530                 535                 540                 


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
545                 550                 555                 560 


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
                565                 570                 575     


Met Val Lys Arg Lys Asp Phe Glu Phe Lys 
            580                 585     


