                         SEQUENCE LISTING

<110>  Neurimmune Holding AG
 
<120>  Human-derived anti-huntingtin (HTT) antibodies and uses thereof

<130>  NE30A51/P-WO

<150>  EP 14179004.8
<151>  2014-07-29

<160>  202   

<170>  PatentIn version 3.5

<210>  1
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  NI-302.33C11-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  1
gag gtg cag ctg gtg gag tct ggg gga ggc gtt gtc cag cct ggg aac         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcg tct gga ttc agg ttc agt gac ttt         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Ser Asp Phe           
            20                  25                  30                    

ggc atg cac tgg gtc cgc cag gct cca ggc aag gga ctg gag tgg ctg        144
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu           
        35                  40                  45                        

gca ctt ata tgg tat gat gga ggg tat aag tac tat gca gac tcc gtg        192
Ala Leu Ile Trp Tyr Asp Gly Gly Tyr Lys Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aat tcc aag aat acg atg ttt        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Phe           
65                  70                  75                  80            

cta caa atg aac agc ctg aga gcc gag gac acg gct gtt tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg acc cac cta gaa tat tgc agt aga acc acc tgc tat ctc ggc cac        336
Ala Thr His Leu Glu Tyr Cys Ser Arg Thr Thr Cys Tyr Leu Gly His           
            100                 105                 110                   

tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                            369
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                               
        115                 120                                           


<210>  2
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Ser Asp Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Gly Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Leu Glu Tyr Cys Ser Arg Thr Thr Cys Tyr Leu Gly His 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  3
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.33C11-VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  3
gac atc cag ttg acc cag tct ccg tcc ttc cta tct gcg tct gtg gga         48
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aca gtc acc ttc act tgc cgg gcc agt cag ggc att agc gat tat         96
Asp Thr Val Thr Phe Thr Cys Arg Ala Ser Gln Gly Ile Ser Asp Tyr           
            20                  25                  30                    

tta gcc tgg ttt cag cag aaa cca ggg att gcc cct aag ctc ctg atc        144
Leu Ala Trp Phe Gln Gln Lys Pro Gly Ile Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat gct gcg tcc act ttg caa acc ggg gtc cca tca agg ttc agc ggc        192
Tyr Ala Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gaa ttc act ctc aca atc cgc agc ctg cag tct        240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Arg Ser Leu Gln Ser           
65                  70                  75                  80            

gaa gat ttt gga act tat tac tgt cag cag ctt aaa act tac ccg tac        288
Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Leu Lys Thr Tyr Pro Tyr           
                85                  90                  95                

act ttt ggc cag ggg acc aag gtg gaa atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  4
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Phe Thr Cys Arg Ala Ser Gln Gly Ile Ser Asp Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Ile Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Arg Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Leu Lys Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  5
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-302.63F3 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  5
cag gtg cag ctg gtg caa tct ggg tct gcg ttc aag aag cct ggg acc         48
Gln Val Gln Leu Val Gln Ser Gly Ser Ala Phe Lys Lys Pro Gly Thr           
1               5                   10                  15                

tca gtg aaa gtt tcc tgc aag gcc tct gga tac acc ttc gag acc cgt         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Glu Thr Arg           
            20                  25                  30                    

tct atg aac tgg gtg cga cag gcc cct gga caa ggg ctt gaa tac atg        144
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Tyr Met           
        35                  40                  45                        

gga tgg atc aac acc aac act ggc aac cgc acg tat gtc cag gcc ttc        192
Gly Trp Ile Asn Thr Asn Thr Gly Asn Arg Thr Tyr Val Gln Ala Phe           
    50                  55                  60                            

aga gga cga ttt gtc ttc tcc ttg gac acc tct gtc agc acg gca tat        240
Arg Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr           
65                  70                  75                  80            

ctg cag atc agc aac tta aag act gag gac act gcc gtg tat tac tgt        288
Leu Gln Ile Ser Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga ggg gca ggt ggg gga tat tgg ttc gac tcc tgg ggc cag gga        336
Ala Arg Gly Ala Gly Gly Gly Tyr Trp Phe Asp Ser Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tcg                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  6
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ser Ala Phe Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Glu Thr Arg 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Arg Thr Tyr Val Gln Ala Phe 
    50                  55                  60                  


Arg Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Gly Gly Tyr Trp Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  7
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-302.63F3 VK  variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  7
gac atc cag atg acc cag tct cca gac tcc ctg gct gtg tct ctg ggc         48
Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

gag agg gcc acc atc aac tgc aag tcc aat cag agt ctt ttc tac agt         96
Glu Arg Ala Thr Ile Asn Cys Lys Ser Asn Gln Ser Leu Phe Tyr Ser           
            20                  25                  30                    

tcc aac aat aac aac tac tta gct tgg tac cag cac aaa tcc gga cag        144
Ser Asn Asn Asn Asn Tyr Leu Ala Trp Tyr Gln His Lys Ser Gly Gln           
        35                  40                  45                        

cct cct aag ctg ctc gtt tac tgg gga tct acc cgg gaa tcc ggg gtc        192
Pro Pro Lys Leu Leu Val Tyr Trp Gly Ser Thr Arg Glu Ser Gly Val           
    50                  55                  60                            

cct gac cgc ttc agt ggc agc ggg tct ggg act gac ttc act ctc acc        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr           
65                  70                  75                  80            

atc agt agc ctg cag gct gag gat gtt gca att tat tac tgt cac caa        288
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys His Gln           
                85                  90                  95                

tat tat cat aat ccg tac act ttt ggc cag ggg acc aag ctg gag atc        336
Tyr Tyr His Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  8
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Asn Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          


Ser Asn Asn Asn Asn Tyr Leu Ala Trp Tyr Gln His Lys Ser Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Val Tyr Trp Gly Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Tyr His Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  9
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-302.35C1 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  9
gag gtg cag ctg gtg gag tct ggg gga aac ttg gta cag ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt act gcc tct gga ttc acc ttt agt ata acg         96
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ile Thr           
            20                  25                  30                    

gcc ctg agt tgg gtc cgc cag gct cca gaa aag ggg ccg cag tgg gtc        144
Ala Leu Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Pro Gln Trp Val           
        35                  40                  45                        

tca gca atc act gga aat gct tat ggg aca tac tac gca gac tcc gtg        192
Ser Ala Ile Thr Gly Asn Ala Tyr Gly Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc att tcc aga gac aac gcc aag aac aca ctg tac        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ttg caa atg aac ggc ctg aga gcc gag gac acg gcc atc tat tac tgt        288
Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gtg aaa gga att gcc tcc gat agt agt ggt tat tct gcc ttc tgg ggc        336
Val Lys Gly Ile Ala Ser Asp Ser Ser Gly Tyr Ser Ala Phe Trp Gly           
            100                 105                 110                   

ccg ggc acc ctg gtc acc gtc tcc tcg                                    363
Pro Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  10
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ile Thr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Pro Gln Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Gly Asn Ala Tyr Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Ile Ala Ser Asp Ser Ser Gly Tyr Ser Ala Phe Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  11
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.35C1 VK variable light -kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  11
gaa att gtg ctg act cag tct cca gcc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt caa agt gtt gac aac cag         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Asn Gln           
            20                  25                  30                    

ttt gcc tgg tac caa cag aaa cct ggc cag gct ccc agg ctc ctc att        144
Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat gat gca tcc agg agg gcc cct ggc atc cca gac agg ttc agt ggc        192
Tyr Asp Ala Ser Arg Arg Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gac ttc act ctc acc att agc agc cta gag cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro           
65                  70                  75                  80            

gaa gat ttc gca att tat tac tgt cag cat cgt tac acc tgg ctc tac        288
Glu Asp Phe Ala Ile Tyr Tyr Cys Gln His Arg Tyr Thr Trp Leu Tyr           
                85                  90                  95                

act ttt ggc cag ggg aca cga ctg gag att aaa                            321
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys                               
            100                 105                                       


<210>  12
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Asn Gln 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Arg Arg Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln His Arg Tyr Thr Trp Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  13
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-302.31F11 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  13
gag gtg cag ctg gtg gag tcc gga gga ggc ttg atc cag ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct ggg ttc acc gtc agc agc acc         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Thr           
            20                  25                  30                    

tac atg agt tgg gtc cgc cag gct cca ggg aag ggg ctt gag tgc gtc        144
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys Val           
        35                  40                  45                        

tca gtt att ttt agt ggc gct gac aca tat tac gca gac tcc gtg aag        192
Ser Val Ile Phe Ser Gly Ala Asp Thr Tyr Tyr Ala Asp Ser Val Lys           
    50                  55                  60                            

ggc cga ttc acc gtc tcc aga gac aat tcc aag aac aca ctg ttt ctt        240
Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu           
65                  70                  75                  80            

cag atg aac agc ctg aga gtc gag gac acg gcc aca tat tac tgt gtg        288
Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Thr Tyr Tyr Cys Val           
                85                  90                  95                

aga cat tat tat ggt tca gac ctt cca tct gac ttc tgg ggc cag ggc        336
Arg His Tyr Tyr Gly Ser Asp Leu Pro Ser Asp Phe Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tcg                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  14
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Thr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Ala Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Arg His Tyr Tyr Gly Ser Asp Leu Pro Ser Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  15
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-302.31F11 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(306)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  15
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc gcc cct gga         48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ala Pro Gly           
1               5                   10                  15                

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc cta tac agt         96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser           
            20                  25                  30                    

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg aag cct        144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Lys Pro           
        35                  40                  45                        

cca cag ctc ctg gtc tat ttg ggt tct gat cgg gcc tcc ggg gtc cct        192
Pro Gln Leu Leu Val Tyr Leu Gly Ser Asp Arg Ala Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agt gga tca ggc aaa gat ttt aca ctg aac atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Phe Thr Leu Asn Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa ggt        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly           
                85                  90                  95                

cta caa agt ccg tgg acg ttc ggc caa ggg acc aag ctg gag atc aaa        336
Leu Gln Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys           
            100                 105                 110                   


<210>  16
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  16

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ala Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Lys Pro 
        35                  40                  45              


Pro Gln Leu Leu Val Tyr Leu Gly Ser Asp Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Phe Thr Leu Asn Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  354
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(354)
<223>  NI-302.2A2 VH  variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(321)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  17
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gtc cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agt acc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr           
            20                  25                  30                    

tgg atg aac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtg        144
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gcc aac ata aaa cca gat gga agt gac aaa tac tat gtg gac tct gtg        192
Ala Asn Ile Lys Pro Asp Gly Ser Asp Lys Tyr Tyr Val Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aac gcc aag aac tca ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gac gag gac acg gct gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga ggg gac ggc agt ggc tgg aac gtc tac tgg ggc cag gga acc        336
Ala Arg Gly Asp Gly Ser Gly Trp Asn Val Tyr Trp Gly Gln Gly Thr           
            100                 105                 110                   

ctg gtc acc gtc tcc tcg                                                354
Leu Val Thr Val Ser Ser                                                   
        115                                                               


<210>  18
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Pro Asp Gly Ser Asp Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Ser Gly Trp Asn Val Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  19
<211>  345
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(345)
<223>  NI-302.2A2 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(129)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (175)..(195)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (292)..(315)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  19
gac atc cag atg acc cag tct cca gac tcc ctg gct gtg tct ctg ggc         48
Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

gag agg gcc acc atc aac tgc aag tcc agc cag agt ctt tta tac acc         96
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr           
            20                  25                  30                    

tcc aaa aat aag gac agt aag aac tac tta ggt tgg tac cag cag aaa        144
Ser Lys Asn Lys Asp Ser Lys Asn Tyr Leu Gly Trp Tyr Gln Gln Lys           
        35                  40                  45                        

cca gga cag cct cct aag ctg ctc att tac tgg gca tct acc cgg gaa        192
Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu           
    50                  55                  60                            

tcc ggg gtc cct gac cga ttc agt ggc agc ggg tct ggg aca gat ttc        240
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe           
65                  70                  75                  80            

act ctc acc atc agc agc ctg cag gct gag gat gtg gca gtt tat tac        288
Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr           
                85                  90                  95                

tgt cag cag tat tat act act cct cag ttc ggc gga ggg acc aag gtg        336
Cys Gln Gln Tyr Tyr Thr Thr Pro Gln Phe Gly Gly Gly Thr Lys Val           
            100                 105                 110                   

gag atc aaa                                                            345
Glu Ile Lys                                                               
        115                                                               


<210>  20
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr 
            20                  25                  30          


Ser Lys Asn Lys Asp Ser Lys Asn Tyr Leu Gly Trp Tyr Gln Gln Lys 
        35                  40                  45              


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
    50                  55                  60                  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
65                  70                  75                  80  


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
                85                  90                  95      


Cys Gln Gln Tyr Tyr Thr Thr Pro Gln Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         


Glu Ile Lys 
        115 


<210>  21
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  NI-302.6N9 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  21
gag gtg cag ctg gtg gag tct ggg gga gac ttg gtg cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gta gtc tct gga ttc acc ttt agt agt tat         96
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg acc tgg gtc cgc cag gct cca ggg aag ggg ctg gcc tgg gtc        144
Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp Val           
        35                  40                  45                        

tca aca att agt gct act ggt ggt agt aca ttc tac aca gac tcc gtg        192
Ser Thr Ile Ser Ala Thr Gly Gly Ser Thr Phe Tyr Thr Asp Ser Val           
    50                  55                  60                            

agg ggc cgg ttc acc atc tcc cga gac aat tcc aag aac aca ctg tat        240
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aat agc ctg aga acc gac gac acg gcc ata tat tat tgt        288
Leu Gln Met Asn Ser Leu Arg Thr Asp Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gtg aaa gat cta ttt gga gtg gac acc tcc tac tac ggt atg gac gtc        336
Val Lys Asp Leu Phe Gly Val Asp Thr Ser Tyr Tyr Gly Met Asp Val           
            100                 105                 110                   

tgg ggc caa ggg acc acg gtc acc gtc tcc tcg                            369
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser                               
        115                 120                                           


<210>  22
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ala Thr Gly Gly Ser Thr Phe Tyr Thr Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Leu Phe Gly Val Asp Thr Ser Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  23
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-302.6N9 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  23
gaa att gtg ttg acg cag tct cca ggc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg ccc agt cag agt gtc agc ggc agg         96
Glu Arg Ala Thr Leu Ser Cys Arg Pro Ser Gln Ser Val Ser Gly Arg           
            20                  25                  30                    

tat gtg gcc tgg tat cag cag aaa cct ggc cag gct ccc agg ctc ctc        144
Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu           
        35                  40                  45                        

ttc tat gct gca tcc aac agg gcc att ggc atc cca gac agg ttc agt        192
Phe Tyr Ala Ala Ser Asn Arg Ala Ile Gly Ile Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag        240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu           
65                  70                  75                  80            

cct gaa gat ttt gca gtg tat tac tgt cag cac tat ggt gcc tca tcg        288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ala Ser Ser           
                85                  90                  95                

tac act ttt ggc ccg ggg acc aaa gtg gat atc aaa                        324
Tyr Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys                           
            100                 105                                       


<210>  24
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Pro Ser Gln Ser Val Ser Gly Arg 
            20                  25                  30          


Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Phe Tyr Ala Ala Ser Asn Arg Ala Ile Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ala Ser Ser 
                85                  90                  95      


Tyr Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  25
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-302.74C11 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(186)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  25
gag gtg cag ctg gtg cag tct ggg act gag gtg cag aag cct ggg gcc         48
Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Gln Lys Pro Gly Ala           
1               5                   10                  15                

tca gta aaa gtc tcc tgc aag gct tct gga tac agt ttc acc ggc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr           
            20                  25                  30                    

ttt ttg cac tgg gta cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Phe Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

ggg tgg atc aac cct aac agt ggt gac aca aac tat gca gag aag ttt        192
Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala Glu Lys Phe           
    50                  55                  60                            

cgg ggc aga atc atc atg acc agg gac acg tct gtc agc aca gcc cac        240
Arg Gly Arg Ile Ile Met Thr Arg Asp Thr Ser Val Ser Thr Ala His           
65                  70                  75                  80            

atg gag ttg agc agc ctg aga ttt gac gac acg gcc cta tat tac tgt        288
Met Glu Leu Ser Ser Leu Arg Phe Asp Asp Thr Ala Leu Tyr Tyr Cys           
                85                  90                  95                

acg aga gag gcc cct gac ccg ggc gct gag acg gac gtc tgg ggc caa        336
Thr Arg Glu Ala Pro Asp Pro Gly Ala Glu Thr Asp Val Trp Gly Gln           
            100                 105                 110                   

ggg acc acg gtc acc gtc tcc tcg                                        360
Gly Thr Thr Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  26
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Gln Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Phe Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ile Ile Met Thr Arg Asp Thr Ser Val Ser Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Phe Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Pro Asp Pro Gly Ala Glu Thr Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  27
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.74C11 VL variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(291)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  27
cag tct gtg ctg act cag cca ccc tcg gtg tca gtg tcc cca gga cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

acg gcc agg atc acc tgc tct gga gat gca gtg cca aag cag tat att         96
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Val Pro Lys Gln Tyr Ile           
            20                  25                  30                    

tat tgg tac cag cag aag cca ggc cag gcc cct att ctg gtg ata tat        144
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ile Leu Val Ile Tyr           
        35                  40                  45                        

aaa gac act cag agg cct tca ggg atc cct gag cga ttc tct ggc tcc        192
Lys Asp Thr Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

aac tca ggg aca aca gtc acg ttg acc ata act ggc gtc cag gca gac        240
Asn Ser Gly Thr Thr Val Thr Leu Thr Ile Thr Gly Val Gln Ala Asp           
65                  70                  75                  80            

gac gag ggt gac tat tac tgt caa tca gca gac agt agt gct act tgg        288
Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Ala Thr Trp           
                85                  90                  95                

gtg ttc ggc gga ggg acc aaa ttg acc gtc cta                            321
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                               
            100                 105                                       


<210>  28
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Val Pro Lys Gln Tyr Ile 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ile Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Thr Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Thr Thr Val Thr Leu Thr Ile Thr Gly Val Gln Ala Asp 
65                  70                  75                  80  


Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Ala Thr Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  29
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-302.15F9 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  29
gag gtg cag ctg gtg gag tct ggg gga ggc ctg gtc acg ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcg tgt gag gcc tct gga ttt ctc ttc aag aat tct         96
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Leu Phe Lys Asn Ser           
            20                  25                  30                    

agc atg aac tgg gtc cgt cag act ccg ggg aag ggg ctg gag tgg gtc        144
Ser Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tcg tcc att gac act tct gct aca aat tat aag tat tat gca gac tct        192
Ser Ser Ile Asp Thr Ser Ala Thr Asn Tyr Lys Tyr Tyr Ala Asp Ser           
    50                  55                  60                            

gtg aag ggc cga ttt acc atc tcc agg gat gac gcc acc aac tct ctc        240
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Thr Asn Ser Leu           
65                  70                  75                  80            

tat ctg caa atg aat agc ctg cga gcc gac gac acg gct act tat tac        288
Tyr Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Thr Tyr Tyr           
                85                  90                  95                

tgt gcg cga ggt tat tat acc ccc cgg gac ttt gac tac tgg ggc cag        336
Cys Ala Arg Gly Tyr Tyr Thr Pro Arg Asp Phe Asp Tyr Trp Gly Gln           
            100                 105                 110                   

ggc acc ctg gtc acc gtc tcc tcg                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  30
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Leu Phe Lys Asn Ser 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asp Thr Ser Ala Thr Asn Tyr Lys Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Thr Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Tyr Tyr Thr Pro Arg Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  31
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-302.15F9 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(306)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  31
gat gtt gtg atg act cag tct cca cag acc ctg tcc gtc agc ctt gga         48
Asp Val Val Met Thr Gln Ser Pro Gln Thr Leu Ser Val Ser Leu Gly           
1               5                   10                  15                

cag gcg gcc tcc atc tcc tgc agg tcg agt caa agc ctc ttg tat cgt         96
Gln Ala Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Arg           
            20                  25                  30                    

gat aac aac aca tac ttg aat tgg ttt cac cag agg cca ggc caa tct        144
Asp Asn Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser           
        35                  40                  45                        

cca agg cgc ctc att tat agg gct tct gac cgg gac tct ggg gtc cca        192
Pro Arg Arg Leu Ile Tyr Arg Ala Ser Asp Arg Asp Ser Gly Val Pro           
    50                  55                  60                            

gac aga ttc agc ggc ggt ggg tca ggc act gat ttc aca ttg aaa atc        240
Asp Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile           
65                  70                  75                  80            

agt gga gtg gag gct gaa gat gtt ggc act tat tac tgc atg caa gga        288
Ser Gly Val Glu Ala Glu Asp Val Gly Thr Tyr Tyr Cys Met Gln Gly           
                85                  90                  95                

aca cac tgg cct cgg acg ttc ggc caa ggg acc aag gtg gag atc aaa        336
Thr His Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys           
            100                 105                 110                   


<210>  32
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  32

Asp Val Val Met Thr Gln Ser Pro Gln Thr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gln Ala Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Arg 
            20                  25                  30          


Asp Asn Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Arg Ala Ser Asp Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Glu Asp Val Gly Thr Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  33
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-302.39G12 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  33
gag gtg cag ctg gtg cag tct ggg gga ggc ttg gtc cac cct tgg ggg         48
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val His Pro Trp Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc agc gtc tct aat tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Asn Tyr           
            20                  25                  30                    

gcc ata act tgg gtc cgc cgg gct cca ggg aag ggg ctg caa tat att        144
Ala Ile Thr Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Gln Tyr Ile           
        35                  40                  45                        

tca gta att tat cgt gat ggc agg aca tac tac gga gac tcc gtg agg        192
Ser Val Ile Tyr Arg Asp Gly Arg Thr Tyr Tyr Gly Asp Ser Val Arg           
    50                  55                  60                            

ggc cgc ttc acc atc tct agg gac gat tcc aag aac act ctc tat ctt        240
Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu           
65                  70                  75                  80            

caa atg aac agc ctg aga ttt gag gac acg gct gtg tat tac tgt gcg        288
Gln Met Asn Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys Ala           
                85                  90                  95                

aga gcg cac ggc caa tat tac tat ggt gtg gac gtc tgg ggc caa ggg        336
Arg Ala His Gly Gln Tyr Tyr Tyr Gly Val Asp Val Trp Gly Gln Gly           
            100                 105                 110                   

acc acg gtc acc gtc tcc tcg                                            357
Thr Thr Val Thr Val Ser Ser                                               
        115                                                               


<210>  34
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val His Pro Trp Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Asn Tyr 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Gln Tyr Ile 
        35                  40                  45              


Ser Val Ile Tyr Arg Asp Gly Arg Thr Tyr Tyr Gly Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala His Gly Gln Tyr Tyr Tyr Gly Val Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  35
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-302.39G12 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(306)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  35
gat gtt gtg atg act cag tct cca ctc tcc ctg tcc gtc agc cct gga         48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly           
1               5                   10                  15                

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc cta cat agt         96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser           
            20                  25                  30                    

aat gga tac aac tat ttg gat tgg tac cgg cag aaa cca ggg cag tct        144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Arg Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca cag ctc ctg atc tat ttg agt tct aat cgg ccc tcc ggg gtc cct        192
Pro Gln Leu Leu Ile Tyr Leu Ser Ser Asn Arg Pro Ser Gly Val Pro           
    50                  55                  60                            

gat agg ttc agt gcc agt gga tca ggc aca gag ttc aca ctg caa atc        240
Asp Arg Phe Ser Ala Ser Gly Ser Gly Thr Glu Phe Thr Leu Gln Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa tct        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser           
                85                  90                  95                

ctg caa acg ttc act ttc ggc gga ggg acc aaa gtg gat atc aaa            333
Leu Gln Thr Phe Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys               
            100                 105                 110                   


<210>  36
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Arg Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Ser Ser Asn Arg Pro Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ala Ser Gly Ser Gly Thr Glu Phe Thr Leu Gln Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Leu Gln Thr Phe Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     


<210>  37
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-302.11A4 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  37
gag gtg cag ctg gtg gag tct gga gga ggc ttg atc cag ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct ggg ttc ccc gtc agt agc agt         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ser Ser Ser           
            20                  25                  30                    

tac atg agc tgg gtc cgc cag gct cca gga gag ggg ctg gag tgg gtc        144
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gtt ctt tat aga gac ggt gac aca tac tac gca gac tcc gtg cag        192
Ser Val Leu Tyr Arg Asp Gly Asp Thr Tyr Tyr Ala Asp Ser Val Gln           
    50                  55                  60                            

ggc cga ttc acc atc tcc aga gac aat tcc cag aac acg ttc tat ctt        240
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Phe Tyr Leu           
65                  70                  75                  80            

caa atg aac agc ctg aaa gcc gag gac acg gcc gtg tat tac tgt gcg        288
Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala           
                85                  90                  95                

ggt gat aga agg tcg tca cac tac tat tac ggt atg gac gtc tgg ggc        336
Gly Asp Arg Arg Ser Ser His Tyr Tyr Tyr Gly Met Asp Val Trp Gly           
            100                 105                 110                   

cag ggg acc acg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Thr Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  38
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Ser Ser Ser 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Leu Tyr Arg Asp Gly Asp Thr Tyr Tyr Ala Asp Ser Val Gln 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Phe Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Asp Arg Arg Ser Ser His Tyr Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  39
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.11A4 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(291)
<223>  complementarity determining region (CDR) VK-CDR2

<400>  39
gaa att gtg atg aca cag tct cca ggc acc ctg tct ttg tct cca gga         48
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt gtt agc agc agc         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser           
            20                  25                  30                    

tac ttc gcc tgg tac caa caa aaa cct ggc cag gct ccc agg ctc ctc        144
Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu           
        35                  40                  45                        

atc tat ggt acg tcc cgc agg gcc act gcc atc cca gac agg ttc agt        192
Ile Tyr Gly Thr Ser Arg Arg Ala Thr Ala Ile Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag        240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu           
65                  70                  75                  80            

cct gaa gat ttt gca gtg tat tac tgt caa cag tat ggt agc tcg tgg        288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Trp           
                85                  90                  95                

acg ttc ggc cca ggg acc aag gtg gag atc aaa                            321
Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  40
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  40

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Arg Arg Ala Thr Ala Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Trp 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  41
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-302.22H9 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  41
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gtc cac cct tgg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Trp Gly           
1               5                   10                  15                

tcc ctg aga gtc tcc tgt gca gcc tct gga ttc agc gtc tct aat tac         96
Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Asn Tyr           
            20                  25                  30                    

gcc ata act tgg gtc cgc cag gct cca ggg aag ggg ctg gaa tat att        144
Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile           
        35                  40                  45                        

tca gtg att tat cgt gat ggc agg aca tac tac gga gac tcc gtg agg        192
Ser Val Ile Tyr Arg Asp Gly Arg Thr Tyr Tyr Gly Asp Ser Val Arg           
    50                  55                  60                            

ggc cgc ttc acc atc tct agg gac gat tcc aag aac act atc tat ctt        240
Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ile Tyr Leu           
65                  70                  75                  80            

caa atg aac agc ctg aga ttt gag gac acg gct gtg tat tac tgt gcg        288
Gln Met Asn Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys Ala           
                85                  90                  95                

aga gcg cac ggc caa tat tat tat ggt gtg gac gtc tgg ggc caa ggg        336
Arg Ala His Gly Gln Tyr Tyr Tyr Gly Val Asp Val Trp Gly Gln Gly           
            100                 105                 110                   

acc acg gtc acc gtc tcc tcg                                            357
Thr Thr Val Thr Val Ser Ser                                               
        115                                                               


<210>  42
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Trp Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Asn Tyr 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Ser Val Ile Tyr Arg Asp Gly Arg Thr Tyr Tyr Gly Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala His Gly Gln Tyr Tyr Tyr Gly Val Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  43
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-302.22H9 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(303)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  43
gat gtt gtg atg act cag tct cca ctc tcc ctg tcc gtc agc cct gga         48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly           
1               5                   10                  15                

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc cta cat agt         96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser           
            20                  25                  30                    

aat gga tac aac tat ttg gat tgg tac cgg cag aaa cca ggg cag tct        144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Arg Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca caa ctc ctg atc tat ttg aat tct aat cgg gcc tcc ggg gtc cct        192
Pro Gln Leu Leu Ile Tyr Leu Asn Ser Asn Arg Ala Ser Gly Val Pro           
    50                  55                  60                            

gat agg ttc agt ggc agt gga tca ggc aca gag ttc aca ctg aca atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa tct        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser           
                85                  90                  95                

ctg caa acg ttc act ttc ggc gga ggg acc aag gtg gag atc aaa            333
Leu Gln Thr Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys               
            100                 105                 110                   


<210>  44
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  44

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Arg Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Asn Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Leu Gln Thr Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  45
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-302.44D7 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  45
gag gtg cag ctg gtg cag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg agt tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca ggt att ggt tat agt gat act agc aca tat tac gca gac tcc gtg        192
Ser Gly Ile Gly Tyr Ser Asp Thr Ser Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgc ttc acc gtc tcc aga gac att tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aat agc ctg agg gcc gag gac acg gcc gta tat tac tgc        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa ggt acc agg gac tat tac ggt atg gac gtc tgg ggc caa ggg        336
Ala Lys Gly Thr Arg Asp Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly           
            100                 105                 110                   

aca atg gtc acc gtc tct tcg                                            357
Thr Met Val Thr Val Ser Ser                                               
        115                                                               


<210>  46
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  46

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Gly Tyr Ser Asp Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Arg Asp Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  47
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-302.44D7 VL variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (192)..(198)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  47
cag act gtg gtg act cag gag cca tcg ttc tca gtg tcc cct gga ggg         48
Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly           
1               5                   10                  15                

aca gtc aca ctc act tgt ggc ttg agt tct ggc tca gtt tct act agt         96
Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Ser           
            20                  25                  30                    

tac tac ccc agc tgg tac cag cag acc cca ggc cgg gct cca cgc acg        144
Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Arg Ala Pro Arg Thr           
        35                  40                  45                        

ctc atc tac agc aca aac act cgc tct tct ggg gtc cct gat cgc ttc        192
Leu Ile Tyr Ser Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe           
    50                  55                  60                            

tct ggc tcc atc ctt ggg aac aag gct gcc ctc acc atc acg ggg gcc        240
Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala           
65                  70                  75                  80            

cag gca gat gat gaa tct gat tat tac tgt gtg ctg ttt atg ggt agt        288
Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Leu Phe Met Gly Ser           
                85                  90                  95                

ggc att ggg gtg ttc ggc gga ggg acc agg ctg acc gtc cta                330
Gly Ile Gly Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu                   
            100                 105                 110                   


<210>  48
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Ser 
            20                  25                  30          


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Arg Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Ser Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Leu Phe Met Gly Ser 
                85                  90                  95      


Gly Ile Gly Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110 


<210>  49
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-302.37C12 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(192)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  49
gag gtg cag ctg gtg gag tct ggt gga ggc ttg gtc cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tct tgt gtt gcc tct gca ctc acc gtc act aac agc         96
Ser Leu Arg Leu Ser Cys Val Ala Ser Ala Leu Thr Val Thr Asn Ser           
            20                  25                  30                    

caa atg acc tgg gtc cgc cgg gct cca ggg agg ggg ttg gag tgg gtc        144
Gln Met Thr Trp Val Arg Arg Ala Pro Gly Arg Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gtt att tac acc agt ggt agt gca tac tac gca gac tcc gtg aag        192
Ser Val Ile Tyr Thr Ser Gly Ser Ala Tyr Tyr Ala Asp Ser Val Lys           
    50                  55                  60                            

ggc aga ttc acc atc tcc aga gac aat tcc aag aac aca gtg ttt ctt        240
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe Leu           
65                  70                  75                  80            

caa atg aac agc ctg aga gtc gaa gac acg gct gtg tat tac tgt gcg        288
Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala           
                85                  90                  95                

aaa ggc cca tca gcc tat tat tac ggt ttg gac ctt tgg ggc caa ggg        336
Lys Gly Pro Ser Ala Tyr Tyr Tyr Gly Leu Asp Leu Trp Gly Gln Gly           
            100                 105                 110                   

acc acg gtc acc gtc tcc tcg                                            357
Thr Thr Val Thr Val Ser Ser                                               
        115                                                               


<210>  50
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Ala Leu Thr Val Thr Asn Ser 
            20                  25                  30          


Gln Met Thr Trp Val Arg Arg Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Thr Ser Gly Ser Ala Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Pro Ser Ala Tyr Tyr Tyr Gly Leu Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  51
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-302.37C12 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(303)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  51
gat att gtg atg act caa tca cca ctc tcc ctg ccc gtc acc cct gga         48
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly           
1               5                   10                  15                

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt         96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser           
            20                  25                  30                    

aat gga tac aac tat ttg gat tgg tac ctg cag aag ccg ggg cag tct        144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca cag ctc ctg atc tat ttg ggt tct act cgg gcc tcc ggg gtc cct        192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Thr Arg Ala Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aag atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa ggt        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly           
                85                  90                  95                

cta cag acg tac act ttt ggc cag ggg acc aag ctg gag atc aaa            333
Leu Gln Thr Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys               
            100                 105                 110                   


<210>  52
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  52

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Thr Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Thr Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  53
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(378)
<223>  NI-302.55D8 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(213)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(345)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  53
cag gtg cag ctg gtg cag tct ggg tct gag gtg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtc tcc tgc aag gct tct gga tac acc ttc acc gac tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr           
            20                  25                  30                    

tat ata cac tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga cgg atc aac cct aac aat ggt ggc aca aac tat gca cag aac ttt        192
Gly Arg Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Ala Gln Asn Phe           
    50                  55                  60                            

cag ggc tgg gtc acc atg acc agg gac acg tcc atc agc aca gcc tac        240
Gln Gly Trp Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctc agc aga ctg aga tct gac gac acg gcc gtc tat tac tgt        288
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gtg ggg ggc gag ctg cta cga gaa ggc ggc tat cac tac tac        336
Ala Arg Val Gly Gly Glu Leu Leu Arg Glu Gly Gly Tyr His Tyr Tyr           
            100                 105                 110                   

atg gac gtc tgg ggc aag ggg acc acg gtc acc gtc tcc tcg                378
Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  54
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Trp Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Gly Glu Leu Leu Arg Glu Gly Gly Tyr His Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  55
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-302.55D8 VL variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(306)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  55
cag tct gtg ttg acg cag ccg ccc tca gtg tct ggg gcc cca ggg cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln           
1               5                   10                  15                

agg gtc acc atc tcc tgc act ggg aac agc tcc aac atc ggg gca ggt         96
Arg Val Thr Ile Ser Cys Thr Gly Asn Ser Ser Asn Ile Gly Ala Gly           
            20                  25                  30                    

tat gat gta cac tgg tac cag cag ctt cca gga aca gcc ccc aaa ctc        144
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu           
        35                  40                  45                        

ctc atc ttt gat aat acc aat cgg ccc tca ggg gtc cct gac cga ttc        192
Leu Ile Phe Asp Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc acc tca gcc tcc ctg gcc atc act ggg ctc        240
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu           
65                  70                  75                  80            

cag gct gag gat gag gct aat tat cac tgc cag tcc tat gac aac agc        288
Gln Ala Glu Asp Glu Ala Asn Tyr His Cys Gln Ser Tyr Asp Asn Ser           
                85                  90                  95                

ctg agt ggt tct tgg gtg ttc ggc gga ggg acc aag ctg acc gtc cta        336
Leu Ser Gly Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu           
            100                 105                 110                   


<210>  56
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Asn Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Phe Asp Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asn Tyr His Cys Gln Ser Tyr Asp Asn Ser 
                85                  90                  95      


Leu Ser Gly Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  57
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  NI-302.7A8 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  57
gag gtg cag ctg gtg gag tct ggg gga ggc tcg gtc cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gta gcc tct gga ttc ata ttt aga aac agt         96
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Arg Asn Ser           
            20                  25                  30                    

tgg atg acc tgg gtc cgc cag gat cca ggg aag ggg ctg gag tgg gtg        144
Trp Met Thr Trp Val Arg Gln Asp Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gcc aac ata aag gaa gat gga agt cgg aca tac tat gtg gac tct gtg        192
Ala Asn Ile Lys Glu Asp Gly Ser Arg Thr Tyr Tyr Val Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aac gcc aag aac tca ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg cag atg aac agc ctg aga gcc gag gac acg gct gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gga gat tat aat tcg ggc atc tat tac ttt ccc ggg gac tac        336
Ala Arg Gly Asp Tyr Asn Ser Gly Ile Tyr Tyr Phe Pro Gly Asp Tyr           
            100                 105                 110                   

tgg ggc cag ggc acc ctg gtc acc gtc tcc tcg                            369
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                               
        115                 120                                           


<210>  58
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Arg Asn Ser 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Asp Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Glu Asp Gly Ser Arg Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Asn Ser Gly Ile Tyr Tyr Phe Pro Gly Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  59
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-302.7A8 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(306)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  59
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc ctt gga         48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly           
1               5                   10                  15                

cag ccg gcc tcc atc tcc tgt agg tct agt caa agc ctc gta tac agt         96
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser           
            20                  25                  30                    

gat gga aac acc tac ttg aat tgg ttt cag cag agg cca ggc cag tct        144
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser           
        35                  40                  45                        

cca agg cgc ctc att tat aag gtt tct aac cgg gac tct ggg gtc cca        192
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro           
    50                  55                  60                            

gac aga ttc agc ggc agt ggg tca ggc act gat ttc aca ctg aga atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile           
65                  70                  75                  80            

agc agg gtg gag gct gag gat gtt ggc att tat tac tgc atg caa ggt        288
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly           
                85                  90                  95                

aca cac tgg cct ggg acg ttc ggc caa ggg acc aag gtg gag atc aaa        336
Thr His Trp Pro Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys           
            100                 105                 110                   


<210>  60
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  60

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  61
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(381)
<223>  NI-302.78H12 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(348)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  61
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgt ctt gtc tct agt tac tcc atc agc aat ggt         96
Thr Leu Ser Leu Thr Cys Leu Val Ser Ser Tyr Ser Ile Ser Asn Gly           
            20                  25                  30                    

tac tac tgg ggc tgg att cgg cag ccc cca ggg aag ggg ctg gag tgg        144
Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

att ggg agt atc tat cat aat ggg aac acc tat tac aac ccg tcc ctc        192
Ile Gly Ser Ile Tyr His Asn Gly Asn Thr Tyr Tyr Asn Pro Ser Leu           
    50                  55                  60                            

aag agt cga gtc atc att tca gta gac acg tcc aag aac cag ttc tcc        240
Lys Ser Arg Val Ile Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser           
65                  70                  75                  80            

ctg aag ttg agg tct gtg acc gcc gca gac acg gcc gtg tac tac tgt        288
Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg atg cca agt gcc acc tat tat tat ggt tcg ggg act caa ttc cat        336
Ala Met Pro Ser Ala Thr Tyr Tyr Tyr Gly Ser Gly Thr Gln Phe His           
            100                 105                 110                   

gcg ttt gat gtc tgg ggc caa ggg acc acg gtc acc gtc tcc tcg            381
Ala Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser               
        115                 120                 125                       


<210>  62
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  62

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Leu Val Ser Ser Tyr Ser Ile Ser Asn Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Asn Gly Asn Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Ile Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Met Pro Ser Ala Thr Tyr Tyr Tyr Gly Ser Gly Thr Gln Phe His 
            100                 105                 110         


Ala Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  63
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-302.78H12 VL variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(303)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  63
cag tct gcc ctg act cag cct cgc tca gtg tcc ggg tct cct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln           
1               5                   10                  15                

tca gtc acc atc tcc tgc act gga acc agc aga gat gtt ggt aat tat         96
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Arg Asp Val Gly Asn Tyr           
            20                  25                  30                    

aac tat gtc tcc tgg tac caa caa cac cca ggc gaa gtc ccc aaa ctc        144
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Glu Val Pro Lys Leu           
        35                  40                  45                        

ata att tat gat gtc agt gag cgg ccc tca ggg gtc cct gat cgc ttc        192
Ile Ile Tyr Asp Val Ser Glu Arg Pro Ser Gly Val Pro Asp Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc aac acg gcc tcg ctg acc atc tct ggg ctc        240
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag gct gag gat gag gct gac tat tac tgc tgc tca tat gct ggc agt        288
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser           
                85                  90                  95                

tac acc ttc gag gta ttt ggc gga ggg acc aag ctg acc gtc cta            333
Tyr Thr Phe Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu               
            100                 105                 110                   


<210>  64
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Arg Asp Val Gly Asn Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Glu Val Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Ser Glu Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Tyr Thr Phe Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  65
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-302.71F6 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  65
cag gtg cag cta cag cag tgg ggc gca gga cta ttg aag cct tcg gag         48
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acg tgc gct gtc tat ggt ggg tcc ctc agt ggt tac         96
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Leu Ser Gly Tyr           
            20                  25                  30                    

tac tgg agc tgg atc cgc cag ccc cca ggg aag ggg ctg gag tgg ata        144
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

ggg gaa gtc aat cat agt gga ggc acc aac ctc aat tcg tcc ctc aag        192
Gly Glu Val Asn His Ser Gly Gly Thr Asn Leu Asn Ser Ser Leu Lys           
    50                  55                  60                            

agt cga gtc atc att tca gta gac aag tcc aag aag cag ttc tcc ctg        240
Ser Arg Val Ile Ile Ser Val Asp Lys Ser Lys Lys Gln Phe Ser Leu           
65                  70                  75                  80            

aaa ctg agc tct gtg acc gcc gcg gac acg gct atg tac ttc tgt gcg        288
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Phe Cys Ala           
                85                  90                  95                

aga gga tac agc tat gac cca aaa tac tac ttt gac tcc tgg agc cag        336
Arg Gly Tyr Ser Tyr Asp Pro Lys Tyr Tyr Phe Asp Ser Trp Ser Gln           
            100                 105                 110                   

ggc acc ctg gtc acc gtc tcc tcg                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  66
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  66

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Leu Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Val Asn His Ser Gly Gly Thr Asn Leu Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Ile Ile Ser Val Asp Lys Ser Lys Lys Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Tyr Ser Tyr Asp Pro Lys Tyr Tyr Phe Asp Ser Trp Ser Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  67
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-302.71F6 VL variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  67
cag tct gcc ctg act cag cct gcc tcc gtg tct ggg tct cct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln           
1               5                   10                  15                

gcg atc acc atc tcc tgc act gga acc agt agt gat att ggg agt tat         96
Ala Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Ser Tyr           
            20                  25                  30                    

gat ttt gtc tcc tgg tac cag cag gac cca ggc aaa gcc ccc aaa gtc        144
Asp Phe Val Ser Trp Tyr Gln Gln Asp Pro Gly Lys Ala Pro Lys Val           
        35                  40                  45                        

att att tat ggg gtc aat aag cgg ccc tca ggg gtt tct aat cgc ttc        192
Ile Ile Tyr Gly Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc aac acg gcc tcc ctg aca atc tct gga ctc        240
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag gct gac gac gag gct gat tat tac tgc tgc tca tat gct ggt agt        288
Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser           
                85                  90                  95                

acc act tgg gtg ttc ggc gga ggg acc aaa ctg acc gtc cta                330
Thr Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  68
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  68

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ala Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Ser Tyr 
            20                  25                  30          


Asp Phe Val Ser Trp Tyr Gln Gln Asp Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              


Ile Ile Tyr Gly Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Thr Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  69
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-302.11H6 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  69
gag gtg cag ctg gtg cag tct gga gct gtg atg aag aag cct gga gac         48
Glu Val Gln Leu Val Gln Ser Gly Ala Val Met Lys Lys Pro Gly Asp           
1               5                   10                  15                

tca gtg agg gtc tcc tgc agg gct tct act tac agc ttt tcc acc tat         96
Ser Val Arg Val Ser Cys Arg Ala Ser Thr Tyr Ser Phe Ser Thr Tyr           
            20                  25                  30                    

agt ttc acc tgg gtg cga cag gtc cct gga caa ggc ctt gag tgg atg        144
Ser Phe Thr Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc agc gct tat aat ggt cac aca aac tat gta gac agc ttc        192
Gly Trp Ile Ser Ala Tyr Asn Gly His Thr Asn Tyr Val Asp Ser Phe           
    50                  55                  60                            

cag ggc aga ctc acg ttg acc aca gac aca tcc gcg agt aca gcg tac        240
Gln Gly Arg Leu Thr Leu Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gaa ctg agg agc ctc aga tct gac gac acg gcc atc tat tat tgt        288
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gcg gct gta gac acc act tac tac tat tac ggc atg gac gtc tgg ggc        336
Ala Ala Val Asp Thr Thr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly           
            100                 105                 110                   

caa ggc acc ctg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  70
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  70

Glu Val Gln Leu Val Gln Ser Gly Ala Val Met Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Arg Ala Ser Thr Tyr Ser Phe Ser Thr Tyr 
            20                  25                  30          


Ser Phe Thr Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly His Thr Asn Tyr Val Asp Ser Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Asp Thr Thr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  71
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-302.11H6 VL variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  71
cag act gtg gtg act cag gag cca acg ttc tca gtg tcc cct gga ggg         48
Gln Thr Val Val Thr Gln Glu Pro Thr Phe Ser Val Ser Pro Gly Gly           
1               5                   10                  15                

aca gtc aca ctc act tgt gcc ttg agg ttt ggc tca gtc tct agt agc         96
Thr Val Thr Leu Thr Cys Ala Leu Arg Phe Gly Ser Val Ser Ser Ser           
            20                  25                  30                    

tac tat ccc agc tgg ttc cag cag acc cca ggc cag gct cca cgc acg        144
Tyr Tyr Pro Ser Trp Phe Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr           
        35                  40                  45                        

ctc atc tac agc aca aac acc cgc tct tcg ggg gtc cct gct cga ttc        192
Leu Ile Tyr Ser Thr Asn Thr Arg Ser Ser Gly Val Pro Ala Arg Phe           
    50                  55                  60                            

tct ggc tcc att ctt ggg aac aaa gct gcc ctc acc atc gcg ggg gcc        240
Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Ala Gly Ala           
65                  70                  75                  80            

cag gca aat gat gag gct gac tat tac tgt gtg ctg tat atg ggt agt        288
Gln Ala Asn Asp Glu Ala Asp Tyr Tyr Cys Val Leu Tyr Met Gly Ser           
                85                  90                  95                

gga atc ggg gtg ttc ggc gga ggg acc aag ttg acc gtc cta                330
Gly Ile Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  72
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  72

Gln Thr Val Val Thr Gln Glu Pro Thr Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Leu Arg Phe Gly Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Tyr Pro Ser Trp Phe Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Ser Thr Asn Thr Arg Ser Ser Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Ala Gly Ala 
65                  70                  75                  80  


Gln Ala Asn Asp Glu Ala Asp Tyr Tyr Cys Val Leu Tyr Met Gly Ser 
                85                  90                  95      


Gly Ile Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  73
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-302.3D8 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (88)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  73
gag gtg cag ctg gtg cag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tct tgt gaa gcc tcc gga ttc atc ttt aaa acc tat         96
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Ile Phe Lys Thr Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag ctt ccc ggg agg ggg ctg gaa tgg gtc        144
Ala Met Ser Trp Val Arg Gln Leu Pro Gly Arg Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gct ata agt gcc act ggt gga agc acc ttc tac gca gag tcc gtg        192
Ser Ala Ile Ser Ala Thr Gly Gly Ser Thr Phe Tyr Ala Glu Ser Val           
    50                  55                  60                            

aag ggc cgg ctc acc att tcc aga gac act gcc aag aat aca gtg tat        240
Lys Gly Arg Leu Thr Ile Ser Arg Asp Thr Ala Lys Asn Thr Val Tyr           
65                  70                  75                  80            

ctg caa atg aac aac ctg aga gcc gaa gac acg gcc atg tat tac tgt        288
Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys           
                85                  90                  95                

gcg aaa ggg tcg act gcg gta tat ctc ttt gac tcc tgg ggc cag gga        336
Ala Lys Gly Ser Thr Ala Val Tyr Leu Phe Asp Ser Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tcg                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  74
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  74

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Ile Phe Lys Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Leu Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Ala Thr Gly Gly Ser Thr Phe Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Thr Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ser Thr Ala Val Tyr Leu Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  75
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.3D8 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  75
gac atc cag atg acc cag tct ccg tcc tca ctg tct gca tct gta ggg         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc ctc act tgt cgg gcg agt cag gac atc aga aat ttc         96
Asp Arg Val Thr Leu Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Phe           
            20                  25                  30                    

ttg gcc tgg att cag cag aag cca ggg aaa ccc cct aag tcc ctg atc        144
Leu Ala Trp Ile Gln Gln Lys Pro Gly Lys Pro Pro Lys Ser Leu Ile           
        35                  40                  45                        

tat gct gcg tcc act ttg caa agt ggg gtc cca tca cga ttc agc ggc        192
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tcc ggg aca gat ttc act ctc acc atc agc agc ctg cac cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu His Pro           
65                  70                  75                  80            

gaa gat ttt gct act tat tac tgc cag cag ttt tat aat tac cct ccg        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Tyr Asn Tyr Pro Pro           
                85                  90                  95                

acg ttc ggc caa ggg acc aag gtg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  76
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  76

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Phe 
            20                  25                  30          


Leu Ala Trp Ile Gln Gln Lys Pro Gly Lys Pro Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu His Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Tyr Asn Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  77
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-302.18A1 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  77
cag ctg cag ctg cag gag tcg ggc cca gga cta gtg aag cct tcg gag         48
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

gcc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc act act gat         96
Ala Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Thr Asp           
            20                  25                  30                    

tat tac tat tgg ggc tgg atc cgc cag tcc cca ggc aag gga cta gag        144
Tyr Tyr Tyr Trp Gly Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg gtt ggg aca ata tac ttt ggt ggg gcc acc tac tac aat ccg tcc        192
Trp Val Gly Thr Ile Tyr Phe Gly Gly Ala Thr Tyr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc agg aac cgg gtc tcg ata tct gtg gac acg tcc aac act cgc ctc        240
Leu Arg Asn Arg Val Ser Ile Ser Val Asp Thr Ser Asn Thr Arg Leu           
65                  70                  75                  80            

tcc ctg aga ctt atc tct ctg agc gcc gct gac acg gcc gtc tat tat        288
Ser Leu Arg Leu Ile Ser Leu Ser Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcg aga gtg ggc tac ttg gat agg agt ggt ctt ctt gtg ggc cag        336
Cys Ala Arg Val Gly Tyr Leu Asp Arg Ser Gly Leu Leu Val Gly Gln           
            100                 105                 110                   

ggc acc ctg gtc acc gtc tcc tcg                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  78
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  78

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Ala Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Thr Asp 
            20                  25                  30          


Tyr Tyr Tyr Trp Gly Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Gly Thr Ile Tyr Phe Gly Gly Ala Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Arg Asn Arg Val Ser Ile Ser Val Asp Thr Ser Asn Thr Arg Leu 
65                  70                  75                  80  


Ser Leu Arg Leu Ile Ser Leu Ser Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Gly Tyr Leu Asp Arg Ser Gly Leu Leu Val Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  79
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-302.18A1 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(306)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  79
gaa att gtg ctg acg cag tct cca ctc tcc gtg ccc gtc acc ccc gga         48
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Val Pro Val Thr Pro Gly           
1               5                   10                  15                

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat aat         96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Asn           
            20                  25                  30                    

aat gga tac aac tat ttg gat tgg tac ctg aag aag cct ggg cag tct        144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Lys Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca caa ctc ctg atc tat ttg ggc tct act cgg gcc tcc ggg gtc cct        192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Thr Arg Ala Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt gcc agt gga tca ggc aca gac ttt aca ctg gaa atc        240
Asp Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile           
65                  70                  75                  80            

agc aga gtg gag gct gaa gat gtt ggc gtt tac tac tgc atg caa gct        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala           
                85                  90                  95                

ctg cag act cct ccg act ttc ggc aga ggg acc aag gtg gag atc aaa        336
Leu Gln Thr Pro Pro Thr Phe Gly Arg Gly Thr Lys Val Glu Ile Lys           
            100                 105                 110                   


<210>  80
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  80

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Asn 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Lys Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Thr Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Pro Thr Phe Gly Arg Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  81
<211>  366
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(366)
<223>  NI-302.8F1 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(204)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (301)..(333)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  81
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gtg aag ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctt aca atc tcc tgt gca gcc tct ggt ttc acc ttc agt aat gcc         96
Ser Leu Thr Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala           
            20                  25                  30                    

tgg atg aac tgg gtc cgc cag gct cca ggt aag ggg ctg gag tgg gtc        144
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

ggc cat att aga acg caa gct gaa gga ggg aca tca gac tat gct gca        192
Gly His Ile Arg Thr Gln Ala Glu Gly Gly Thr Ser Asp Tyr Ala Ala           
    50                  55                  60                            

ccc gtg aaa ggc aga ttc acc atc tca aga gat gac tca aaa aac acg        240
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr           
65                  70                  75                  80            

ctg tat ctg caa atg aac agc ctg aaa acc gag gac aca gcc gta tat        288
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr           
                85                  90                  95                

tat tgt atc ccc ccc ccc tac tac tac tat tac ggt ctg gac gtc tgg        336
Tyr Cys Ile Pro Pro Pro Tyr Tyr Tyr Tyr Tyr Gly Leu Asp Val Trp           
            100                 105                 110                   

ggc caa ggg acc acg gtc acc gtc tcc tcg                                366
Gly Gln Gly Thr Thr Val Thr Val Ser Ser                                   
        115                 120                                           


<210>  82
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly His Ile Arg Thr Gln Ala Glu Gly Gly Thr Ser Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ile Pro Pro Pro Tyr Tyr Tyr Tyr Tyr Gly Leu Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  83
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-302.8F1 VL variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(297)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  83
cag tct gcc ctg act cag cct gcc tcc gtg tct ggg tct cct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln           
1               5                   10                  15                

tcg atc acc atc tcc tgc act gga gcc agc agt gat gtt ggg act tat         96
Ser Ile Thr Ile Ser Cys Thr Gly Ala Ser Ser Asp Val Gly Thr Tyr           
            20                  25                  30                    

gac ctt gtc tcc tgg tac caa caa cat cca ggc aaa gcc ccc aaa ctc        144
Asp Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu           
        35                  40                  45                        

att att tat gag gtc aat aag cgg ccc tca ggg gtt tct tat cgc ttc        192
Ile Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Val Ser Tyr Arg Phe           
    50                  55                  60                            

tct gcc tcc aag tct gcc aac acg gcc tcc ctg aca ata tct ggg ctc        240
Ser Ala Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag gct gag gac gag gct gaa tat tac tgc tgc tca tat gca ggt tat        288
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Cys Ser Tyr Ala Gly Tyr           
                85                  90                  95                

agc acg gta ttc ggc gga ggg acc aag ctg acc gtc cta                    327
Ser Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                       
            100                 105                                       


<210>  84
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  84

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Ala Ser Ser Asp Val Gly Thr Tyr 
            20                  25                  30          


Asp Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Val Ser Tyr Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Cys Ser Tyr Ala Gly Tyr 
                85                  90                  95      


Ser Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  85
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-302.52C9 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  85
gag gtg cag ctg gtg cag tct ggg gga ggc ttg gtc caa cct ggg ggg         48
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca ggc tct gga ttc acc gtc agt gac acc         96
Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Val Ser Asp Thr           
            20                  25                  30                    

tac atg agt tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca ggt att cat gcc ggt ggt gaa aca tat tac gca gac tcc gtg aag        192
Ser Gly Ile His Ala Gly Gly Glu Thr Tyr Tyr Ala Asp Ser Val Lys           
    50                  55                  60                            

ggc cga ttc acc atc tcc aga gac aac tcc aag aac acg ctg tat ctt        240
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu           
65                  70                  75                  80            

caa atg aat agg ctg aca cct gag gac acg gct gtc ttt tat tgt gcg        288
Gln Met Asn Arg Leu Thr Pro Glu Asp Thr Ala Val Phe Tyr Cys Ala           
                85                  90                  95                

aga cac tac tac ggt aat gac gac gac act gat tat tgg ggc cag gga        336
Arg His Tyr Tyr Gly Asn Asp Asp Asp Thr Asp Tyr Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tcg                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  86
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  86

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Val Ser Asp Thr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile His Ala Gly Gly Glu Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Arg Leu Thr Pro Glu Asp Thr Ala Val Phe Tyr Cys Ala 
                85                  90                  95      


Arg His Tyr Tyr Gly Asn Asp Asp Asp Thr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  87
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-302.52C9 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(306)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  87
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc acc cct gga         48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly           
1               5                   10                  15                

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt         96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser           
            20                  25                  30                    

aat gga tac aac tat ttg gat tgg tac gtg cag aag cca ggg cag tct        144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Val Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca cag ctc ctc atc tat ttg ggt tct act cgg gcc tcc ggg gtc cct        192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Thr Arg Ala Ser Gly Val Pro           
    50                  55                  60                            

gac aga ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc tta caa gct        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ala           
                85                  90                  95                

caa caa att ccg tgg acg ttc ggc caa ggg acc aag gtg gag atc aaa        336
Gln Gln Ile Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys           
            100                 105                 110                   


<210>  88
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  88

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Val Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Thr Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ala 
                85                  90                  95      


Gln Gln Ile Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  89
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  NI-302.46C9 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  89
cag gtg cag ctg cag gag tcg ggc cca gga ctg gta aag cct tca cag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln           
1               5                   10                  15                

acc ctg tcc ctc acc tgc act gtt tct ggt gcc tcc gtc agc agt ggt         96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Val Ser Ser Gly           
            20                  25                  30                    

gcc tac tac tgg agt tgg atc cgg cag ccc gcc ggg aag cga ctg gag        144
Ala Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Arg Leu Glu           
        35                  40                  45                        

tgg att ggg cgt gtc tat ccc act tgg agc acc aac tac aac ccc tcc        192
Trp Ile Gly Arg Val Tyr Pro Thr Trp Ser Thr Asn Tyr Asn Pro Ser           
    50                  55                  60                            

ctc gag agt cga gtc acc ata tcg tta gac acg tcc aac aac cag ttc        240
Leu Glu Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Asn Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aag ctg acc tct ttg act gcc gca gac acg gcc gtt tat tac        288
Ser Leu Lys Leu Thr Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcg aga gag gct cct ggt gac tac gat gct gcg ccc cta gcc tac        336
Cys Ala Arg Glu Ala Pro Gly Asp Tyr Asp Ala Ala Pro Leu Ala Tyr           
            100                 105                 110                   

tgg ggc cag ggc acc ctg gtc acc gtc tcc tcg                            369
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                               
        115                 120                                           


<210>  90
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  90

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Val Ser Ser Gly 
            20                  25                  30          


Ala Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Arg Leu Glu 
        35                  40                  45              


Trp Ile Gly Arg Val Tyr Pro Thr Trp Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Asn Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ala Pro Gly Asp Tyr Asp Ala Ala Pro Leu Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  91
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.46C9 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  91
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gtt gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gca agt cag tac att agc cac tat         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Tyr Ile Ser His Tyr           
            20                  25                  30                    

tta aat tgg tat cgg cag aaa cca ggg aaa gcc cct cag ctc gta atc        144
Leu Asn Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Gln Leu Val Ile           
        35                  40                  45                        

tat gct gca tcc agt ttg caa agt gag gtc cca tca agg ttc agt ggg        192
Tyr Ala Ala Ser Ser Leu Gln Ser Glu Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg cca gag ttc act ctc acc atc agc agt ctg caa cct        240
Ser Gly Ser Gly Pro Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gca act tat tac tgt caa cag agt tac act acc cct cga        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Arg           
                85                  90                  95                

act ttt ggc cag ggg acc aag ctg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                               
            100                 105                                       


<210>  92
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Tyr Ile Ser His Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Gln Leu Val Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Glu Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Pro Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  93
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSA-coupled synthetic peptides (Schafer-N, Denmark) of the HTT 
       exon 1 N-terminal amino acids 1-19

<400>  93

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln 
            


<210>  94
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSA-coupled synthetic peptides (Schafer-N, Denmark) of the HTT 
       exon 1 P-rich domain

<400>  94

Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro 
1               5                   10                  15      


Gln Pro Gln Pro Pro 
            20      


<210>  95
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSA-coupled synthetic peptides (Schafer-N, Denmark) of the HTT 
       exon 1polyP repeat

<400>  95

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10      


<210>  96
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSA-coupled synthetic peptides (Schafer-N, Denmark) of the HTT 
       exon 1 C-terminal amino acids

<400>  96

Pro Pro Gly Pro Ala Val Ala Glu Glu Pro Leu His Arg Pro 
1               5                   10                  


<210>  97
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  NI-302.33C11-PIMC VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  97
cag gtg cag ctg gtg gag tct ggg gga ggc gtt gtc cag cct ggg aac         48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcg tct gga ttc agg ttc agt gac ttt         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Ser Asp Phe           
            20                  25                  30                    

ggc atg cac tgg gtc cgc cag gct cca ggc aag gga ctg gag tgg ctg        144
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu           
        35                  40                  45                        

gca ctt ata tgg tat gat gga ggg tat aag tac tat gca gac tcc gtg        192
Ala Leu Ile Trp Tyr Asp Gly Gly Tyr Lys Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aat tcc aag aat acg atg ttt        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Phe           
65                  70                  75                  80            

cta caa atg aac agc ctg aga gcc gag gac acg gct gtt tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg acc cac cta gaa tat tgc agt aga acc acc tgc tat ctc ggc cac        336
Ala Thr His Leu Glu Tyr Cys Ser Arg Thr Thr Cys Tyr Leu Gly His           
            100                 105                 110                   

tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                            369
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                               
        115                 120                                           


<210>  98
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  98

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Ser Asp Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Gly Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Leu Glu Tyr Cys Ser Arg Thr Thr Cys Tyr Leu Gly His 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  99
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.33C11-PIMC VK variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  99
gac atc cag ttg acc cag tct ccg tcc ttc cta tct gcg tct gtg gga         48
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aca gtc acc ttc act tgc cgg gcc agt cag ggc att agc gat tat         96
Asp Thr Val Thr Phe Thr Cys Arg Ala Ser Gln Gly Ile Ser Asp Tyr           
            20                  25                  30                    

tta gcc tgg ttt cag cag aaa cca ggg att gcc cct aag ctc ctg atc        144
Leu Ala Trp Phe Gln Gln Lys Pro Gly Ile Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat gct gcg tcc act ttg caa acc ggg gtc cca tca agg ttc agc ggc        192
Tyr Ala Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gaa ttc act ctc aca atc cgc agc ctg cag tct        240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Arg Ser Leu Gln Ser           
65                  70                  75                  80            

gaa gat ttt gga act tat tac tgt cag cag ctt aaa act tac ccg tac        288
Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Leu Lys Thr Tyr Pro Tyr           
                85                  90                  95                

act ttt ggc cag ggg acc aag ctg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                               
            100                 105                                       


<210>  100
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  100

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Phe Thr Cys Arg Ala Ser Gln Gly Ile Ser Asp Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Ile Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Arg Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Leu Lys Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  101
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-307.63F3-PIMC VK variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  101
gat att gtg atg act caa tca cca gac tcc ctg gct gtg tct ctg ggc         48
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

gag agg gcc acc atc aac tgc aag tcc aat cag agt ctt ttc tac agt         96
Glu Arg Ala Thr Ile Asn Cys Lys Ser Asn Gln Ser Leu Phe Tyr Ser           
            20                  25                  30                    

tcc aac aat aac aac tac tta gct tgg tac cag cac aaa tcc gga cag        144
Ser Asn Asn Asn Asn Tyr Leu Ala Trp Tyr Gln His Lys Ser Gly Gln           
        35                  40                  45                        

cct cct aag ctg ctc gtt tac tgg gga tct acc cgg gaa tcc ggg gtc        192
Pro Pro Lys Leu Leu Val Tyr Trp Gly Ser Thr Arg Glu Ser Gly Val           
    50                  55                  60                            

cct gac cgc ttc agt ggc agc ggg tct ggg act gac ttc act ctc acc        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr           
65                  70                  75                  80            

atc agt agc ctg cag gct gag gat gtt gca att tat tac tgt cac caa        288
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys His Gln           
                85                  90                  95                

tat tat cat aat ccg tac act ttt ggc cag ggg acc aag ctg gag atc        336
Tyr Tyr His Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  102
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  102

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Asn Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          


Ser Asn Asn Asn Asn Tyr Leu Ala Trp Tyr Gln His Lys Ser Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Val Tyr Trp Gly Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Tyr His Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  103
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-307.63F3-PIMC-NS VK variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  103
gat att gtg atg act caa tca cca gac tcc ctg gct gtg tct ctg ggc         48
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

gag agg gcc acc atc aac tgc aag tcc tca cag agt ctt ttc tac agt         96
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser           
            20                  25                  30                    

tcc aac aat aac aac tac tta gct tgg tac cag cac aaa tcc gga cag        144
Ser Asn Asn Asn Asn Tyr Leu Ala Trp Tyr Gln His Lys Ser Gly Gln           
        35                  40                  45                        

cct cct aag ctg ctc gtt tac tgg gga tct acc cgg gaa tcc ggg gtc        192
Pro Pro Lys Leu Leu Val Tyr Trp Gly Ser Thr Arg Glu Ser Gly Val           
    50                  55                  60                            

cct gac cgc ttc agt ggc agc ggg tct ggg act gac ttc act ctc acc        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr           
65                  70                  75                  80            

atc agt agc ctg cag gct gag gat gtt gca att tat tac tgt cac caa        288
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys His Gln           
                85                  90                  95                

tat tat cat aat ccg tac act ttt ggc cag ggg acc aag ctg gag atc        336
Tyr Tyr His Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  104
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  104

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          


Ser Asn Asn Asn Asn Tyr Leu Ala Trp Tyr Gln His Lys Ser Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Val Tyr Trp Gly Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Tyr His Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  105
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-307.63F3-PIMC-SG VK variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  105
gat att gtg atg act caa tca cca gac tcc ctg gct gtg tct ctg ggc         48
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

gag agg gcc acc atc aac tgc aag tcc aat cag ggc ctt ttc tac agt         96
Glu Arg Ala Thr Ile Asn Cys Lys Ser Asn Gln Gly Leu Phe Tyr Ser           
            20                  25                  30                    

tcc aac aat aac aac tac tta gct tgg tac cag cac aaa tcc gga cag        144
Ser Asn Asn Asn Asn Tyr Leu Ala Trp Tyr Gln His Lys Ser Gly Gln           
        35                  40                  45                        

cct cct aag ctg ctc gtt tac tgg gga tct acc cgg gaa tcc ggg gtc        192
Pro Pro Lys Leu Leu Val Tyr Trp Gly Ser Thr Arg Glu Ser Gly Val           
    50                  55                  60                            

cct gac cgc ttc agt ggc agc ggg tct ggg act gac ttc act ctc acc        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr           
65                  70                  75                  80            

atc agt agc ctg cag gct gag gat gtt gca att tat tac tgt cac caa        288
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys His Gln           
                85                  90                  95                

tat tat cat aat ccg tac act ttt ggc cag ggg acc aag ctg gag atc        336
Tyr Tyr His Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  106
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  106

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Asn Gln Gly Leu Phe Tyr Ser 
            20                  25                  30          


Ser Asn Asn Asn Asn Tyr Leu Ala Trp Tyr Gln His Lys Ser Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Val Tyr Trp Gly Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Tyr His Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  107
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-307.63F3-PIMC-NQ VK variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  107
gat att gtg atg act caa tca cca gac tcc ctg gct gtg tct ctg ggc         48
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

gag agg gcc acc atc aac tgc aag tcc caa cag agt ctt ttc tac agt         96
Glu Arg Ala Thr Ile Asn Cys Lys Ser Gln Gln Ser Leu Phe Tyr Ser           
            20                  25                  30                    

tcc aac aat aac aac tac tta gct tgg tac cag cac aaa tcc gga cag        144
Ser Asn Asn Asn Asn Tyr Leu Ala Trp Tyr Gln His Lys Ser Gly Gln           
        35                  40                  45                        

cct cct aag ctg ctc gtt tac tgg gga tct acc cgg gaa tcc ggg gtc        192
Pro Pro Lys Leu Leu Val Tyr Trp Gly Ser Thr Arg Glu Ser Gly Val           
    50                  55                  60                            

cct gac cgc ttc agt ggc agc ggg tct ggg act gac ttc act ctc acc        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr           
65                  70                  75                  80            

atc agt agc ctg cag gct gag gat gtt gca att tat tac tgt cac caa        288
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys His Gln           
                85                  90                  95                

tat tat cat aat ccg tac act ttt ggc cag ggg acc aag ctg gag atc        336
Tyr Tyr His Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  108
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  108

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Gln Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          


Ser Asn Asn Asn Asn Tyr Leu Ala Trp Tyr Gln His Lys Ser Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Val Tyr Trp Gly Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Tyr His Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  109
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.35C1-PIMC VK variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  109
gaa att gtg ctg act cag tct cca gcc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt caa agt gtt gac aac cag         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Asn Gln           
            20                  25                  30                    

ttt gcc tgg tac caa cag aaa cct ggc cag gct ccc agg ctc ctc att        144
Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat gat gca tcc agg agg gcc cct ggc atc cca gac agg ttc agt ggc        192
Tyr Asp Ala Ser Arg Arg Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gac ttc act ctc acc att agc agc cta gag cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro           
65                  70                  75                  80            

gaa gat ttc gca att tat tac tgt cag cat cgt tac acc tgg ctc tac        288
Glu Asp Phe Ala Ile Tyr Tyr Cys Gln His Arg Tyr Thr Trp Leu Tyr           
                85                  90                  95                

act ttt ggc cag ggg acc aag ctg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                               
            100                 105                                       


<210>  110
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  110

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Asn Gln 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Arg Arg Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln His Arg Tyr Thr Trp Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  111
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-302.31F11-PIMC VK variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(306)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  111
gat att gtg atg act caa tca cca ctc tcc ctg ccc gtc gcc cct gga         48
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ala Pro Gly           
1               5                   10                  15                

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc cta tac agt         96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser           
            20                  25                  30                    

aat gga tac aac tat ttg gat tgg tac ctg cag aag cca ggg aag cct        144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Lys Pro           
        35                  40                  45                        

cca cag ctc ctg gtc tat ttg ggt tct gat cgg gcc tcc ggg gtc cct        192
Pro Gln Leu Leu Val Tyr Leu Gly Ser Asp Arg Ala Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agt gga tca ggc aaa gat ttt aca ctg aac atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Phe Thr Leu Asn Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa ggt        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly           
                85                  90                  95                

cta caa agt ccg tgg acg ttc ggc caa ggg acc aag gtg gaa atc aaa        336
Leu Gln Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys           
            100                 105                 110                   


<210>  112
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  112

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ala Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Lys Pro 
        35                  40                  45              


Pro Gln Leu Leu Val Tyr Leu Gly Ser Asp Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Phe Thr Leu Asn Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  113
<211>  345
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(345)
<223>  NI-302.2A2-PIMC VK variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(129)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (175)..(195)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (292)..(315)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  113
gat att gtg atg act caa tca cca gac tcc ctg gct gtg tct ctg ggc         48
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

gag agg gcc acc atc aac tgc aag tcc agc cag agt ctt tta tac acc         96
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr           
            20                  25                  30                    

tcc aaa aat aag gac agt aag aac tac tta ggt tgg tac cag cag aaa        144
Ser Lys Asn Lys Asp Ser Lys Asn Tyr Leu Gly Trp Tyr Gln Gln Lys           
        35                  40                  45                        

cca gga cag cct cct aag ctg ctc att tac tgg gca tct acc cgg gaa        192
Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu           
    50                  55                  60                            

tcc ggg gtc cct gac cga ttc agt ggc agc ggg tct ggg aca gat ttc        240
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe           
65                  70                  75                  80            

act ctc acc atc agc agc ctg cag gct gag gat gtg gca gtt tat tac        288
Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr           
                85                  90                  95                

tgt cag cag tat tat act act cct cag ttc ggc gga ggg acc aag gtg        336
Cys Gln Gln Tyr Tyr Thr Thr Pro Gln Phe Gly Gly Gly Thr Lys Val           
            100                 105                 110                   

gaa atc aaa                                                            345
Glu Ile Lys                                                               
        115                                                               


<210>  114
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  114

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr 
            20                  25                  30          


Ser Lys Asn Lys Asp Ser Lys Asn Tyr Leu Gly Trp Tyr Gln Gln Lys 
        35                  40                  45              


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
    50                  55                  60                  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
65                  70                  75                  80  


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
                85                  90                  95      


Cys Gln Gln Tyr Tyr Thr Thr Pro Gln Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         


Glu Ile Lys 
        115 


<210>  115
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-302.74C11-PIMC VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(186)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  115
cag gtg cag ctg gtg caa tct ggg act gag gtg cag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Gln Lys Pro Gly Ala           
1               5                   10                  15                

tca gta aaa gtc tcc tgc aag gct tct gga tac agt ttc acc ggc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr           
            20                  25                  30                    

ttt ttg cac tgg gta cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Phe Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

ggg tgg atc aac cct aac agt ggt gac aca aac tat gca gag aag ttt        192
Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala Glu Lys Phe           
    50                  55                  60                            

cgg ggc aga atc atc atg acc agg gac acg tct gtc agc aca gcc cac        240
Arg Gly Arg Ile Ile Met Thr Arg Asp Thr Ser Val Ser Thr Ala His           
65                  70                  75                  80            

atg gag ttg agc agc ctg aga ttt gac gac acg gcc cta tat tac tgt        288
Met Glu Leu Ser Ser Leu Arg Phe Asp Asp Thr Ala Leu Tyr Tyr Cys           
                85                  90                  95                

acg aga gag gcc cct gac ccg ggc gct gag acg gac gtc tgg ggc caa        336
Thr Arg Glu Ala Pro Asp Pro Gly Ala Glu Thr Asp Val Trp Gly Gln           
            100                 105                 110                   

gga acc acg gtc acc gtc tcc tcg                                        360
Gly Thr Thr Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  116
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  116

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Gln Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Phe Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ile Ile Met Thr Arg Asp Thr Ser Val Ser Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Phe Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Pro Asp Pro Gly Ala Glu Thr Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  117
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.74C11-PIMC VL variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(291)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  117
tcc tat gag ctg act cag cca ccc tcg gtg tca gtg tcc cca gga cag         48
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

acg gcc agg atc acc tgc tct gga gat gca gtg cca aag cag tat att         96
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Val Pro Lys Gln Tyr Ile           
            20                  25                  30                    

tat tgg tac cag cag aag cca ggc cag gcc cct att ctg gtg ata tat        144
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ile Leu Val Ile Tyr           
        35                  40                  45                        

aaa gac act cag agg cct tca ggg atc cct gag cga ttc tct ggc tcc        192
Lys Asp Thr Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

aac tca ggg aca aca gtc acg ttg acc ata act ggc gtc cag gca gac        240
Asn Ser Gly Thr Thr Val Thr Leu Thr Ile Thr Gly Val Gln Ala Asp           
65                  70                  75                  80            

gac gag ggt gac tat tac tgt caa tca gca gac agt agt gct act tgg        288
Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Ala Thr Trp           
                85                  90                  95                

gtg ttc ggc gga ggg acc aaa ttg acc gtc cta                            321
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                               
            100                 105                                       


<210>  118
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  118

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Val Pro Lys Gln Tyr Ile 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ile Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Thr Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Thr Thr Val Thr Leu Thr Ile Thr Gly Val Gln Ala Asp 
65                  70                  75                  80  


Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Ala Thr Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  119
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-302.39G12-PIMC VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  119
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gtc cac cct tgg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Trp Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc agc gtc tct aat tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Asn Tyr           
            20                  25                  30                    

gcc ata act tgg gtc cgc cgg gct cca ggg aag ggg ctg caa tat att        144
Ala Ile Thr Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Gln Tyr Ile           
        35                  40                  45                        

tca gta att tat cgt gat ggc agg aca tac tac gga gac tcc gtg agg        192
Ser Val Ile Tyr Arg Asp Gly Arg Thr Tyr Tyr Gly Asp Ser Val Arg           
    50                  55                  60                            

ggc cgc ttc acc atc tct agg gac gat tcc aag aac act ctc tat ctt        240
Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu           
65                  70                  75                  80            

caa atg aac agc ctg aga ttt gag gac acg gct gtg tat tac tgt gcg        288
Gln Met Asn Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys Ala           
                85                  90                  95                

aga gcg cac ggc caa tat tac tat ggt gtg gac gtc tgg ggc caa gga        336
Arg Ala His Gly Gln Tyr Tyr Tyr Gly Val Asp Val Trp Gly Gln Gly           
            100                 105                 110                   

acc acg gtc acc gtc tcc tcg                                            357
Thr Thr Val Thr Val Ser Ser                                               
        115                                                               


<210>  120
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Trp Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Asn Tyr 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Gln Tyr Ile 
        35                  40                  45              


Ser Val Ile Tyr Arg Asp Gly Arg Thr Tyr Tyr Gly Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala His Gly Gln Tyr Tyr Tyr Gly Val Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  121
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-302.39G12-PIMC VK variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(303)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  121
gac atc gtg atg acc cag tct cca ctc tcc ctg tcc gtc agc cct gga         48
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly           
1               5                   10                  15                

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc cta cat agt         96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser           
            20                  25                  30                    

aat gga tac aac tat ttg gat tgg tac cgg cag aaa cca ggg cag tct        144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Arg Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca cag ctc ctg atc tat ttg agt tct aat cgg ccc tcc ggg gtc cct        192
Pro Gln Leu Leu Ile Tyr Leu Ser Ser Asn Arg Pro Ser Gly Val Pro           
    50                  55                  60                            

gat agg ttc agt gcc agt gga tca ggc aca gag ttc aca ctg caa atc        240
Asp Arg Phe Ser Ala Ser Gly Ser Gly Thr Glu Phe Thr Leu Gln Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa tct        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser           
                85                  90                  95                

ctg caa acg ttc act ttc ggc gga ggg acc aag gtg gaa atc aaa            333
Leu Gln Thr Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys               
            100                 105                 110                   


<210>  122
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  122

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Arg Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Ser Ser Asn Arg Pro Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ala Ser Gly Ser Gly Thr Glu Phe Thr Leu Gln Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Leu Gln Thr Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  123
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.11A4-PIMC VK variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  123
gaa att gtg ctg act cag tct cca ggc acc ctg tct ttg tct cca gga         48
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt gtt agc agc agc         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser           
            20                  25                  30                    

tac ttc gcc tgg tac caa caa aaa cct ggc cag gct ccc agg ctc ctc        144
Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu           
        35                  40                  45                        

atc tat ggt acg tcc cgc agg gcc act gcc atc cca gac agg ttc agt        192
Ile Tyr Gly Thr Ser Arg Arg Ala Thr Ala Ile Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag        240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu           
65                  70                  75                  80            

cct gaa gat ttt gca gtg tat tac tgt caa cag tat ggt agc tcg tgg        288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Trp           
                85                  90                  95                

acg ttc ggc cca ggg acc aag gtg gaa atc aaa                            321
Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  124
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  124

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Arg Arg Ala Thr Ala Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Trp 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  125
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-302.22H9-PIMC VK variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(303)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  125
gat att gtg atg act caa tca cca ctc tcc ctg tcc gtc agc cct gga         48
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly           
1               5                   10                  15                

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc cta cat agt         96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser           
            20                  25                  30                    

aat gga tac aac tat ttg gat tgg tac cgg cag aaa cca ggg cag tct        144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Arg Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca caa ctc ctg atc tat ttg aat tct aat cgg gcc tcc ggg gtc cct        192
Pro Gln Leu Leu Ile Tyr Leu Asn Ser Asn Arg Ala Ser Gly Val Pro           
    50                  55                  60                            

gat agg ttc agt ggc agt gga tca ggc aca gag ttc aca ctg aca atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc atg caa tct        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser           
                85                  90                  95                

ctg caa acg ttc act ttc ggc gga ggg acc aag gtg gaa atc aaa            333
Leu Gln Thr Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys               
            100                 105                 110                   


<210>  126
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  126

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Arg Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Asn Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Leu Gln Thr Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  127
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-302.44D7-PIMC VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  127
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg agt tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca ggt att ggt tat agt gat act agc aca tat tac gca gac tcc gtg        192
Ser Gly Ile Gly Tyr Ser Asp Thr Ser Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgc ttc acc gtc tcc aga gac att tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aat agc ctg agg gcc gag gac acg gcc gta tat tac tgc        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa ggt acc agg gac tat tac ggt atg gac gtc tgg ggc caa gga        336
Ala Lys Gly Thr Arg Asp Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly           
            100                 105                 110                   

acc acg gtc acc gtc tcc tcg                                            357
Thr Thr Val Thr Val Ser Ser                                               
        115                                                               


<210>  128
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  128

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Gly Tyr Ser Asp Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Arg Asp Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  129
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(381)
<223>  NI-302.78H12-PIMC VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(348)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  129
cag ctg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgt ctt gtc tct agt tac tcc atc agc aat ggt         96
Thr Leu Ser Leu Thr Cys Leu Val Ser Ser Tyr Ser Ile Ser Asn Gly           
            20                  25                  30                    

tac tac tgg ggc tgg att cgg cag ccc cca ggg aag ggg ctg gag tgg        144
Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

att ggg agt atc tat cat aat ggg aac acc tat tac aac ccg tcc ctc        192
Ile Gly Ser Ile Tyr His Asn Gly Asn Thr Tyr Tyr Asn Pro Ser Leu           
    50                  55                  60                            

aag agt cga gtc atc att tca gta gac acg tcc aag aac cag ttc tcc        240
Lys Ser Arg Val Ile Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser           
65                  70                  75                  80            

ctg aag ttg agg tct gtg acc gcc gca gac acg gcc gtg tac tac tgt        288
Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg atg cca agt gcc acc tat tat tat ggt tcg ggg act caa ttc cat        336
Ala Met Pro Ser Ala Thr Tyr Tyr Tyr Gly Ser Gly Thr Gln Phe His           
            100                 105                 110                   

gcg ttt gat gtc tgg ggc caa ggg aca atg gtc acc gtc tct tcg            381
Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser               
        115                 120                 125                       


<210>  130
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  130

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Leu Val Ser Ser Tyr Ser Ile Ser Asn Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Asn Gly Asn Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Ile Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Met Pro Ser Ala Thr Tyr Tyr Tyr Gly Ser Gly Thr Gln Phe His 
            100                 105                 110         


Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  131
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(384)
<223>  NI-302.15E8 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(351)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  131
gag gtg cag ctg gtg gag tct ggg gga ggc ttg ata cag ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gtc tct gga ttc acc gtc agt agt tat         96
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Ser Ser Tyr           
            20                  25                  30                    

agc atg aac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca tac act agt agt agc aga agt aat acc aaa aag tac gca gac tct        192
Ser Tyr Thr Ser Ser Ser Arg Ser Asn Thr Lys Lys Tyr Ala Asp Ser           
    50                  55                  60                            

gtg aag ggc cga ttc acc atc tct aga gac aat gcc agg aac tca ctc        240
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu           
65                  70                  75                  80            

tat ctg caa atg aac agc ctg aga gac gag gac acg gct gtg tat tac        288
Tyr Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcg aga gca ggg gac ttc ggg gag tta ctc act ggt gag ggg tat        336
Cys Ala Arg Ala Gly Asp Phe Gly Glu Leu Leu Thr Gly Glu Gly Tyr           
            100                 105                 110                   

tac ggt atg gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc tcg        384
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser           
        115                 120                 125                       


<210>  132
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Thr Ser Ser Ser Arg Ser Asn Thr Lys Lys Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Gly Asp Phe Gly Glu Leu Leu Thr Gly Glu Gly Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  133
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(318)
<223>  NI-302.15E8 VL variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(288)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  133
tcc tat gag ctg act cag cca ccc tca gtg tcc gtg tcc cca gga cag         48
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

aca gcc acc atc acc tgc tcg gga gat gaa ttg ggg gat aaa tat gtt         96
Thr Ala Thr Ile Thr Cys Ser Gly Asp Glu Leu Gly Asp Lys Tyr Val           
            20                  25                  30                    

ggt tgg tat caa cag aag cca ggc cag tcc cct ctg ctg gtc atc tat        144
Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Leu Leu Val Ile Tyr           
        35                  40                  45                        

caa gat gcg aag cgg ccc tca ggg atc cct gag cga ttc tct ggc tcc        192
Gln Asp Ala Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

aac tct ggg aac aca gcc act ctg acc atc agc ggg acc cag gct atg        240
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met           
65                  70                  75                  80            

gat gag gct gac tac tac tgt cag gcg tgg gac agc ggc acg atg gtt        288
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Gly Thr Met Val           
                85                  90                  95                

ttc ggc gga ggg acc agg ctg acc gtc cta                                318
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu                                   
            100                 105                                       


<210>  134
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  134

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Ser Gly Asp Glu Leu Gly Asp Lys Tyr Val 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Leu Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ala Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Gly Thr Met Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105     


<210>  135
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-302.15D3 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  135
gag gtg cag ctg gtg gag tct ggg gga gac tta gtt cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc cta aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt agc tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

tgg atg cac tgg gtc cgc caa gct cca ggg aag ggt ctg gtg tgg gtc        144
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val           
        35                  40                  45                        

tca cgt att agt aat gat ggc agt agc aaa acc tac gcg gac tcc gtg        192
Ser Arg Ile Ser Asn Asp Gly Ser Ser Lys Thr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aac gcc aaa aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agt ctg aga gcc gag gac acg gct gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca ata ctt ggc gga tat tgt agt agt acc agt tgt cgt ccc ttt gac        336
Ala Ile Leu Gly Gly Tyr Cys Ser Ser Thr Ser Cys Arg Pro Phe Asp           
            100                 105                 110                   

aac tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                        372
Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  136
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Asn Asp Gly Ser Ser Lys Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Leu Gly Gly Tyr Cys Ser Ser Thr Ser Cys Arg Pro Phe Asp 
            100                 105                 110         


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  137
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-302.15D3 VL variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  137
cag tct gcc ctg act cag cct gcc tcc gtg tct ggg tct cct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln           
1               5                   10                  15                

tcg atc acc atc tcc tgc act gga acc agc agt gac gtt ggt gtt tat         96
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Val Tyr           
            20                  25                  30                    

aac tat gtc tcc tgg tac caa caa cac cca ggc aaa gcc ccc aaa ctc        144
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu           
        35                  40                  45                        

atg att ttt gat gtc agt aat cgg ccc tca ggg att tct aat cgc ttc        192
Met Ile Phe Asp Val Ser Asn Arg Pro Ser Gly Ile Ser Asn Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc aac acg gcc tcc ctg acc atc tct ggg ctc        240
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag gct gag gac gag gct gat tat tac tgc agc tca tat aca agc agc        288
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser           
                85                  90                  95                

gac act tgg gtg ttc ggc gga ggg acc aag ctg acc atc cta                330
Asp Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Ile Leu                   
            100                 105                 110                   


<210>  138
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  138

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Val Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Phe Asp Val Ser Asn Arg Pro Ser Gly Ile Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Asp Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Ile Leu 
            100                 105                 110 


<210>  139
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.33C11 antibody

<400>  139

Pro Pro Pro Pro Pro Pro Pro Pro 
1               5               


<210>  140
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.63F3 antibody

<400>  140

Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu 
1               5                   10  


<210>  141
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   Epitope of NI-302.31F11 antibody

<400>  141

Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro 
1               5                   10  


<210>  142
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.2A2 antibody

<400>  142

Gln Ala Gln Pro Leu Leu Pro Gln Pro Gln Pro Pro Pro Pro Pro 
1               5                   10                  15  


<210>  143
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI302.15D3 antibody

<400>  143

Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu 
1               5                   10                  15  


<210>  144
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI302.15E8 antibody

<400>  144

Lys Ala Phe Glu Ser Leu Lys Ser Phe Gln Gln 
1               5                   10      


<210>  145
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.35C1 antibody

<400>  145

Pro Pro Gly Pro Ala Val Ala Glu Glu Pro Leu His Arg Pro 
1               5                   10                  


<210>  146
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.74C11 antibody

<400>  146

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10      


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.15F9 antibody

<400>  147

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10      


<210>  148
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.39G12 antibody

<400>  148

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10      


<210>  149
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.11A4 antibody

<400>  149

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10      


<210>  150
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.22H9 antibody

<400>  150

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10      


<210>  151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.44D7 antibody

<400>  151

Pro Pro Pro Pro Pro Pro Pro Pro 
1               5               


<210>  152
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.37C12 antibody

<400>  152

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10      


<210>  153
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.55D8 antibody

<400>  153

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10      


<210>  154
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.7A8 antibody

<400>  154

Pro Pro Pro Pro Pro Pro Pro Pro 
1               5               


<210>  155
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.78H12 antibody

<400>  155

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10      


<210>  156
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.71F6  antibody

<400>  156

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10      


<210>  157
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.11H6 antibody

<400>  157

Pro Pro Pro Pro Pro Pro 
1               5       


<210>  158
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.3D8 antibody

<400>  158

Pro Pro Pro Pro Pro Pro Pro Pro 
1               5               


<210>  159
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.18A1antibody

<400>  159

Pro Pro Pro Pro Pro Pro 
1               5       


<210>  160
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.52C9 antibody

<400>  160

Pro Pro Pro Pro Pro Pro 
1               5       


<210>  161
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-302.46C9 antibody

<400>  161

Pro Pro Pro Pro Pro Pro Pro Pro 
1               5               


<210>  162
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative epitope of NI-302.63F3 antibody

<400>  162

Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu 
1               5                   10                  15  


<210>  163
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative epitope of NI-302.33C11 antibody

<400>  163

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10      


<210>  164
<211>  366
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(366)
<223>  NI-302.64E5-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(204)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (301)..(355)
<223>  complementarity determining region (CDR) VH-CDR2

<400>  164
gag gtg cag ctg gtg gag act ggg gga ggc ttg gta aag cct ggg ggg         48
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctt aga ctc tcc tgt gca gcc tct gga ttc act ttc gac cag gcc         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gln Ala           
            20                  25                  30                    

tgg atg agc tgg gtc cgc cag gtt cca ggg aag ggg ctg gag tgg gtt        144
Trp Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

ggc cgg att aaa acg aaa act gag ggt gaa gca aca gac tac gca gcg        192
Gly Arg Ile Lys Thr Lys Thr Glu Gly Glu Ala Thr Asp Tyr Ala Ala           
    50                  55                  60                            

ccc gtg aga ggc aga ttc acc atc tca aga gat gat tca gaa gac acg        240
Pro Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Asp Thr           
65                  70                  75                  80            

gtg ttt ctg caa atg aac agc ctg aaa acc gag gac aca gcc ctg tat        288
Val Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Leu Tyr           
                85                  90                  95                

tac tgt acg tca acg gga gtc tta gca gca gct gtc gat gtc tac tgg        336
Tyr Cys Thr Ser Thr Gly Val Leu Ala Ala Ala Val Asp Val Tyr Trp           
            100                 105                 110                   

ggc cag gga acc ctg gtc acc gtc tcc tcg                                366
Gly Gln Gly Thr Leu Val Thr Val Ser Ser                                   
        115                 120                                           


<210>  165
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  165

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gln Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Thr Lys Thr Glu Gly Glu Ala Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Asp Thr 
65                  70                  75                  80  


Val Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Thr Ser Thr Gly Val Leu Ala Ala Ala Val Asp Val Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  166
<211>  366
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(366)
<223>  NI-302.64E5-PIMC VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(204)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (301)..(355)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  166
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta aag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctt aga ctc tcc tgt gca gcc tct gga ttc act ttc gac cag gcc         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gln Ala           
            20                  25                  30                    

tgg atg agc tgg gtc cgc cag gtt cca ggg aag ggg ctg gag tgg gtt        144
Trp Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

ggc cgg att aaa acg aaa act gag ggt gaa gca aca gac tac gca gcg        192
Gly Arg Ile Lys Thr Lys Thr Glu Gly Glu Ala Thr Asp Tyr Ala Ala           
    50                  55                  60                            

ccc gtg aga ggc aga ttc acc atc tca aga gat gat tca gaa gac acg        240
Pro Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Asp Thr           
65                  70                  75                  80            

gtg ttt ctg caa atg aac agc ctg aaa acc gag gac aca gcc ctg tat        288
Val Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Leu Tyr           
                85                  90                  95                

tac tgt acg tca acg gga gtc tta gca gca gct gtc gat gtc tac tgg        336
Tyr Cys Thr Ser Thr Gly Val Leu Ala Ala Ala Val Asp Val Tyr Trp           
            100                 105                 110                   

ggc cag ggc acc ctg gtc acc gtc tcc tcg                                366
Gly Gln Gly Thr Leu Val Thr Val Ser Ser                                   
        115                 120                                           


<210>  167
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  167

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gln Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Thr Lys Thr Glu Gly Glu Ala Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Asp Thr 
65                  70                  75                  80  


Val Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Thr Ser Thr Gly Val Leu Ala Ala Ala Val Asp Val Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  168
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-302.64E5 VK  variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  168
gac atc cag ttg acc cag tct cca gac tcc ctg gct gtg tct ctg ggc         48
Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

gag agg gcc acc atg acc tgc aag tcc agc cag agt ctt ttc tac agt         96
Glu Arg Ala Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser           
            20                  25                  30                    

tac aac aat gag aac tac tta gcc tgg tat cag cag aga cca gga cag        144
Tyr Asn Asn Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln           
        35                  40                  45                        

cct cct aag ttg ctc att tac tgg gca tct acc cgg gaa tcc ggg gtc        192
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val           
    50                  55                  60                            

cct gac cga ttc agt ggc agc ggg tct ggg aca gat ttc act ctc acc        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr           
65                  70                  75                  80            

atc agc agc ctg cag gct gaa gat gtg gca gtt tat tac tgt cag caa        288
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln           
                85                  90                  95                

tat tat agt act cct cag acg ttc ggc caa ggg acc aaa gtg gat atc        336
Tyr Tyr Ser Thr Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Asp Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  169
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  169

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          


Tyr Asn Asn Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Asp Ile 
            100                 105                 110         


Lys 
    


<210>  170
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-302.64E5-PIMC VK variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  170
gat att gtg atg act caa tca cca gac tcc ctg gct gtg tct ctg ggc         48
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

gag agg gcc acc atg acc tgc aag tcc agc cag agt ctt ttc tac agt         96
Glu Arg Ala Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser           
            20                  25                  30                    

tac aac aat gag aac tac tta gcc tgg tat cag cag aga cca gga cag        144
Tyr Asn Asn Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln           
        35                  40                  45                        

cct cct aag ttg ctc att tac tgg gca tct acc cgg gaa tcc ggg gtc        192
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val           
    50                  55                  60                            

cct gac cga ttc agt ggc agc ggg tct ggg aca gat ttc act ctc acc        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr           
65                  70                  75                  80            

atc agc agc ctg cag gct gaa gat gtg gca gtt tat tac tgt cag caa        288
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln           
                85                  90                  95                

tat tat agt act cct cag acg ttc ggc caa ggg acc aag gtg gaa atc        336
Tyr Tyr Ser Thr Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  171
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  171

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          


Tyr Asn Asn Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  172
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-302.7D8-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  172
cag gtg cag ctg gtg caa tct gga tct gag ttg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtt tcc tgc aag gct tct gga tac aac ttc aat aac tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Asn Asn Tyr           
            20                  25                  30                    

gcc atc aat tgg ttg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Ala Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac acc atc act ggg cac cca acg tat gcc cag ggc ttc        192
Gly Trp Ile Asn Thr Ile Thr Gly His Pro Thr Tyr Ala Gln Gly Phe           
    50                  55                  60                            

aaa gga cga ttt gtc ttc tcc ttg gac acc tct gtc agc acg gca tat        240
Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr           
65                  70                  75                  80            

ctg cag atc agc agc cta aag cct gag gac act gcc gtc tat tac tgt        288
Leu Gln Ile Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga act tac agt aac tac ggc gaa ttt gac tac tgg ggc cag gga        336
Ala Arg Thr Tyr Ser Asn Tyr Gly Glu Phe Asp Tyr Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tcg                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  173
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  173

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Asn Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Ile Thr Gly His Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Tyr Ser Asn Tyr Gly Glu Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  174
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-302.7D8 VL  variable light-lambda chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(303)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  174
cag tct gcc ctg act cag cct gcc tcc gtg tct ggg tct cgt gga cag         48
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Arg Gly Gln           
1               5                   10                  15                

tcg atc acc atc tcc tgc act gga acc agc agt gat gtt gga agt tat         96
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr           
            20                  25                  30                    

aac ctt gtc tcc tgg tac caa cag tac cca ggc aag gcc ccc aag ctc        144
Asn Leu Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu           
        35                  40                  45                        

ata att cat gag ggc agt gag cgg ccc tca ggg gtt tct aat cgc ttc        192
Ile Ile His Glu Gly Ser Glu Arg Pro Ser Gly Val Ser Asn Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc aac acg gcc tcc ctg aca att tct ggg ctc        240
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag gct gag gac gag gct gat tat tac tgc tgc tca tat gca ggt act        288
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Thr           
                85                  90                  95                

act act ttc gtg cta ttc ggc gga ggg acc aag ctg acc gtc ctc            333
Thr Thr Phe Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu               
            100                 105                 110                   


<210>  175
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  175

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Arg Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile His Glu Gly Ser Glu Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Thr 
                85                  90                  95      


Thr Thr Phe Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  176
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-302.72F10-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(324)
<223>  complementarity determining region (CDR) VH-CDR2

<400>  176
gag gtg cag ctg gtg gag act ggg gga ggc ttc gta cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Phe Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc aac ttc ggc agt tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Gly Ser Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag gct cca ggg aag gga ctg gag tgg gtg        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gat atc agt ggt att ggt agt aac aca tac tac gca gac tcc gtg        192
Ser Asp Ile Ser Gly Ile Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgt ttc acc att tcc aga gac aat tcc gac aat acg ttg tac        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asp Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg gac atg agc agc ctg aga gcc gag gac acg gcc aga tat tac tgt        288
Leu Asp Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Arg Tyr Tyr Cys           
                85                  90                  95                

gcg aag gat cga aag cgc agt ggc tgg tac gaa cag tgg ggc cag ggc        336
Ala Lys Asp Arg Lys Arg Ser Gly Trp Tyr Glu Gln Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tcg                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  177
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  177

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Gly Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Gly Ile Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asp Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Asp Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Lys Arg Ser Gly Trp Tyr Glu Gln Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  178
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-302.72F10-PIMC VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  178
gag gtg cag ctg gtg gag tct ggg gga ggc ttc gta cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc aac ttc ggc agt tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Gly Ser Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag gct cca ggg aag gga ctg gag tgg gtg        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gat atc agt ggt att ggt agt aac aca tac tac gca gac tcc gtg        192
Ser Asp Ile Ser Gly Ile Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgt ttc acc att tcc aga gac aat tcc gac aat acg ttg tac        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asp Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg gac atg agc agc ctg aga gcc gag gac acg gcc aga tat tac tgt        288
Leu Asp Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Arg Tyr Tyr Cys           
                85                  90                  95                

gcg aag gat cga aag cgc agt ggc tgg tac gaa cag tgg ggc cag ggc        336
Ala Lys Asp Arg Lys Arg Ser Gly Trp Tyr Glu Gln Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tcg                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  179
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Gly Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Gly Ile Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asp Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Asp Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Lys Arg Ser Gly Trp Tyr Glu Gln Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  180
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.72F10 VK  variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  180
gaa att gtg atg aca cag tct cca gcc acc ctg act ttg tct cca ggg         48
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Thr Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt att agc gcc tac         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ala Tyr           
            20                  25                  30                    

tta ggc tgg tat caa caa aaa cct ggc cag gct ccc agg ctc ctc atc        144
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat gat gca tcc att agg gcc act ggc att cca gac agg ttt agt ggc        192
Tyr Asp Ala Ser Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gac ttc act ctc acc atc agc agc cta gag cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro           
65                  70                  75                  80            

gaa gat tct gca gtt tat tac tgt cac cag cgt agc aag tgg cct ctt        288
Glu Asp Ser Ala Val Tyr Tyr Cys His Gln Arg Ser Lys Trp Pro Leu           
                85                  90                  95                

act ttc ggc gga ggg acc aag gtg gaa atc aaa                            321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  181
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  181

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Thr Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ala Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Val Tyr Tyr Cys His Gln Arg Ser Lys Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  182
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.72F10-PIMC VK variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  182
gaa att gtg ctg act cag tct cca gcc acc ctg act ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Thr Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt att agc gcc tac         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ala Tyr           
            20                  25                  30                    

tta ggc tgg tat caa caa aaa cct ggc cag gct ccc agg ctc ctc atc        144
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat gat gca tcc att agg gcc act ggc att cca gac agg ttt agt ggc        192
Tyr Asp Ala Ser Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gac ttc act ctc acc atc agc agc cta gag cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro           
65                  70                  75                  80            

gaa gat tct gca gtt tat tac tgt cac cag cgt agc aag tgg cct ctt        288
Glu Asp Ser Ala Val Tyr Tyr Cys His Gln Arg Ser Lys Trp Pro Leu           
                85                  90                  95                

act ttc ggc gga ggg acc aag gtg gaa atc aaa                            321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  183
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  183

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Thr Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ala Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Val Tyr Tyr Cys His Gln Arg Ser Lys Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  184
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(378)
<223>  NI-302.4A6-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  184
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc gct tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca act att agt ggt agt ggt ggt agt aca tac tac gca gac tcc gtg        192
Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc tcc atc tcc aga gac aac tcc aaa aac acc ctg tat        240
Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gcc gta tat ttc tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gcg aaa gtt acc acg gaa ctc tac ggt gct aac tcc tac tac tac tac        336
Ala Lys Val Thr Thr Glu Leu Tyr Gly Ala Asn Ser Tyr Tyr Tyr Tyr           
            100                 105                 110                   

atg gac gtc tgg ggc aaa ggg acc acg gtc acc gtc tcc tcg                378
Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  185
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  185

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Val Thr Thr Glu Leu Tyr Gly Ala Asn Ser Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  186
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.4A6 VK  variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (286)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  186
gaa att gtg ttg aca cag tct cca ggc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt gtt gtc agc agg         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Val Ser Arg           
            20                  25                  30                    

tat tta gcc tgg tac cag caa aaa cct ggc cag gct ccc agg ctc ctc        144
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu           
        35                  40                  45                        

atc tat ggt gca tcc agc agg gcc act ggc atc cca gac agg ttc agt        192
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag        240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu           
65                  70                  75                  80            

cct gaa gat ttt gca atg tat tac tgt cag ctg tat ggt aac tca cag        288
Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Leu Tyr Gly Asn Ser Gln           
                85                  90                  95                

acg ttc ggc cag ggg acc aag gtg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  187
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  187

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Val Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Leu Tyr Gly Asn Ser Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  188
<211>  375
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(375)
<223>  NI-302.12H2-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(342)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  188
gag gtg cag ctg gtg cag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctt tcc tgt gaa gcc tct gga ttc acc ttt agc aac tat         96
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Asn Tyr           
            20                  25                  30                    

gcc atg ggc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gta att agt ggt act ggt ggt agc aca tac tac gca gac tcc gtg        192
Ser Val Ile Ser Gly Thr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tcc atg aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Met Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ccg aga gcc gac gac acg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Pro Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa gat ctg agg aag att agc ggt cct tta tac tac tac ggt atg        336
Ala Lys Asp Leu Arg Lys Ile Ser Gly Pro Leu Tyr Tyr Tyr Gly Met           
            100                 105                 110                   

gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc tcg                    375
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser                       
        115                 120                 125                       


<210>  189
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  189

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Thr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Met Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Pro Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Lys Ile Ser Gly Pro Leu Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  190
<211>  375
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(375)
<223>  NI-302.12H2-PIMC VH variable heavy chain (VH) sequence

<220>
<221>  V_rehion
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_rehion
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_rehion
<222>  (295)..(342)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  190
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctt tcc tgt gaa gcc tct gga ttc acc ttt agc aac tat         96
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Asn Tyr           
            20                  25                  30                    

gcc atg ggc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gta att agt ggt act ggt ggt agc aca tac tac gca gac tcc gtg        192
Ser Val Ile Ser Gly Thr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tcc atg aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Met Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ccg aga gcc gac gac acg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Pro Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa gat ctg agg aag att agc ggt cct tta tac tac tac ggt atg        336
Ala Lys Asp Leu Arg Lys Ile Ser Gly Pro Leu Tyr Tyr Tyr Gly Met           
            100                 105                 110                   

gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc tcg                    375
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser                       
        115                 120                 125                       


<210>  191
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  191

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Thr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Met Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Pro Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Lys Ile Ser Gly Pro Leu Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  192
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-302.12H2 VK  variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(294)
<223>  complementarity determining region (CDR) VK-CDR2

<400>  192
gaa att gtg ttg acg cag tct cca ggc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt gtt agc agc ggc         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Gly           
            20                  25                  30                    

tac tta gcc tgg tac cag cag aaa cct ggc cag gct ccc agg ctc ctc        144
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu           
        35                  40                  45                        

atc tat ggt gca tcc acc agg gcc act ggc atc cca gac agg ttc agt        192
Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag        240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu           
65                  70                  75                  80            

cct gaa gat ttt gca gtg tat tac tgt cag cac tat ggt gcc tca tcg        288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ala Ser Ser           
                85                  90                  95                

tac act ttt ggc cag ggg acc aag ctg gag atc aaa                        324
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                           
            100                 105                                       


<210>  193
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  193

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ala Ser Ser 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  194
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-302.8M1-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  194
gag gtc cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc         48
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aaa gtt tcc tgc aag gca tcc gga tac acc ttc acc atc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr           
            20                  25                  30                    

tat atg cac tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga gga atc agc ccg agt ggt gcc cac aca atg tac gca cag aat ttc        192
Gly Gly Ile Ser Pro Ser Gly Ala His Thr Met Tyr Ala Gln Asn Phe           
    50                  55                  60                            

cag ggc aga gtc acc gtg acc agg gac acg tcc acg agc aca gtc tac        240
Gln Gly Arg Val Thr Val Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr           
65                  70                  75                  80            

atg gag ctg agc agc ctg aga tct gag gac acg gcc gtg tat tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga ggg agc acg gtg act aac tat cga ccc ttt gac tac tgg ggc        336
Ala Arg Gly Ser Thr Val Thr Asn Tyr Arg Pro Phe Asp Tyr Trp Gly           
            100                 105                 110                   

cag gga acc ctg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  195
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  195

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Ser Gly Ala His Thr Met Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Val Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Thr Val Thr Asn Tyr Arg Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  196
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-302.8M1-PIMC VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  196
cag gtg cag ctg gtg caa tct ggg gct gag gtg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aaa gtt tcc tgc aag gca tcc gga tac acc ttc acc atc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr           
            20                  25                  30                    

tat atg cac tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga gga atc agc ccg agt ggt gcc cac aca atg tac gca cag aat ttc        192
Gly Gly Ile Ser Pro Ser Gly Ala His Thr Met Tyr Ala Gln Asn Phe           
    50                  55                  60                            

cag ggc aga gtc acc gtg acc agg gac acg tcc acg agc aca gtc tac        240
Gln Gly Arg Val Thr Val Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr           
65                  70                  75                  80            

atg gag ctg agc agc ctg aga tct gag gac acg gcc gtg tat tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga ggg agc acg gtg act aac tat cga ccc ttt gac tac tgg ggc        336
Ala Arg Gly Ser Thr Val Thr Asn Tyr Arg Pro Phe Asp Tyr Trp Gly           
            100                 105                 110                   

cag ggc acc ctg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  197
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  197

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Ser Gly Ala His Thr Met Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Val Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Thr Val Thr Asn Tyr Arg Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  198
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-302.8M1 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  198
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc act atc act tgc cgg gcg agt cag gac att agc aat tat         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr           
            20                  25                  30                    

tta gcc tgg tat cag cag aaa cca ggg aaa gtt cct aaa ctc ctg atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile           
        35                  40                  45                        

ttt gct gca tcc act ttg caa tca ggg gtc ccg tct cgg ttc ggt ggc        192
Phe Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Gly Gly           
    50                  55                  60                            

agt gga tct ggg aca gat ttc act ctc acc atc agc agc ctg cag cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat gtt gca act tat tac tgt caa aac tat aac agt ggc cct ccg        288
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Tyr Asn Ser Gly Pro Pro           
                85                  90                  95                

cct ttc ggc cct ggg acc aaa gtg gat atc aaa                            321
Pro Phe Gly Pro Gly Thr Lys Val Asp Ile Lys                               
            100                 105                                       


<210>  199
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  199

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Gly Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Tyr Asn Ser Gly Pro Pro 
                85                  90                  95      


Pro Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  200
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope recognized by NI-302.64E5

<400>  200

Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu 
1               5                   10  


<210>  201
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope recognized by NI-302.7D8

<400>  201

Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro 
1               5                   10  


<210>  202
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope recognized by NI-302.72F10

<400>  202

Pro Pro Pro Gly Pro Ala Val Ala Glu Glu Pro Leu His 
1               5                   10              


