                         SEQUENCE LISTING

<110>  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
 
<120>  MODIFIED ANTIMIR-138 OLIGONUCLEOTIDES

<130>  9869SG3309

<150>  SG 10201404535S
<151>  2014-07-31

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  1
agctggtgtt gtgaatcagg ccg                                               23


<210>  2
<211>  23
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ANTI-MIR 138

<400>  2
cggccugaut cacaacacca gcu                                               23


<210>  3
<211>  23
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ANTI-MIR 138

<400>  3
cggccugauu cacaacacca gcu                                               23


<210>  4
<211>  11
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ANTI-MIR-138

<400>  4
acaacaccag c                                                            11


<210>  5
<211>  11
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  AMO_138_11_CAP_PS OR ANTI-MIR138-4


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<400>  5
acaacaccag c                                                            11


<210>  6
<211>  11
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  AMO_CONTROL_11_CAP_PS


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<400>  6
caaacaccga c                                                            11


<210>  7
<211>  23
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  AMO_138_23


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (16)..(17)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (19)..(20)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (20)..(22)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (22)..(23)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  CHOLESTEROL_CAP
<222>  (23)..(23)

<400>  7
cggcctgatu cacaacacca gcu                                               23


<210>  8
<211>  23
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  AMO_CONTROL_23


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (16)..(17)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (19)..(20)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (20)..(22)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (22)..(23)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  CHOLESTEROL_CAP
<222>  (23)..(23)

<400>  8
ggcaatccaa cggaccutca ccu                                               23


<210>  9
<211>  23
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  AMO_106_23


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (19)..(23)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (20)..(22)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  CHOLESTEROL_CAP
<222>  (23)..(23)

<400>  9
cuacctgcac uguaagcacu uuu                                               23


<210>  10
<211>  23
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  AMO_138_23_1 OR ANTI-MIR138-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (19)..(23)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (20)..(22)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<400>  10
cggcctgaut cacaacacca gcu                                               23


<210>  11
<211>  23
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  AMO_CONTROL_23_1


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (16)..(17)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (19)..(20)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (20)..(22)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (22)..(23)
<223>  MODIFIED WITH 2'-O-METHYLATION

<400>  11
ggcaatccaa cggaccutca ccu                                               23


<210>  12
<211>  23
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  AMO_138_23_2 OR ANTI-MIR138-2


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (16)..(17)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (19)..(20)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (20)..(22)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (22)..(23)
<223>  MODIFIED WITH 2'-O-METHYLATION

<400>  12
cggcctgatu cacaacacca gcu                                               23


<210>  13
<211>  23
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  AMO_138_23_3 OR ANTI-MIR138-3


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (20)..(22)
<223>  MODIFIED WITH PHOSPHOROTHIOATE LINKAGE

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  MODIFIED WITH 2'-O-METHYLATION

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  MODIFIED WITH LOCKED NUCLEIC ACID MODIFICATION

<220>
<221>  MISC_FEATURE
<222>  (22)..(23)
<223>  MODIFIED WITH 2'-O-METHYLATION

<400>  13
cggccugaut cacaacacca gcu                                               23


