                         SEQUENCE LISTING

<110>  Northwestern University
       Satchell, Karla J.F.
       Antic, Irena
       Biancucci, Marco
 
<120>  BACTERIAL TOXINS AND USES THEREOF AS RAS SPECIFIC PROTEASES

<130>  5369-00107

<150>  62/032,330
<151>  2014-08-01

<150>  62/172,432
<151>  2015-06-08

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  510
<212>  PRT
<213>  Vibrio vulnificus

<400>  1

Gly Asp Lys Thr Lys Val Val Val Asp Leu Ala Gln Ile Phe Thr Val 
1               5                   10                  15      


Gln Glu Leu Lys Glu Arg Ala Lys Val Phe Ala Lys Pro Ile Gly Ala 
            20                  25                  30          


Ser Tyr Gln Gly Ile Leu Asp Gln Leu Asp Leu Val His Gln Ala Lys 
        35                  40                  45              


Gly Arg Asp Gln Ile Ala Ala Ser Phe Glu Leu Asn Lys Lys Ile Asn 
    50                  55                  60                  


Asp Tyr Ile Ala Glu His Pro Thr Ser Gly Arg Asn Gln Ala Leu Thr 
65                  70                  75                  80  


Gln Leu Lys Glu Gln Val Thr Ser Ala Leu Phe Ile Gly Lys Met Gln 
                85                  90                  95      


Val Ala Gln Ala Gly Ile Asp Ala Ile Ala Gln Thr Arg Pro Glu Leu 
            100                 105                 110         


Ala Ala Arg Ile Phe Met Val Ala Ile Glu Glu Ala Asn Gly Lys His 
        115                 120                 125             


Val Gly Leu Thr Asp Met Met Val Arg Trp Ala Asn Glu Asp Pro Tyr 
    130                 135                 140                 


Leu Ala Pro Lys His Gly Tyr Lys Gly Glu Thr Pro Ser Asp Leu Gly 
145                 150                 155                 160 


Phe Asp Ala Lys Tyr His Val Asp Leu Gly Glu His Tyr Ala Asp Phe 
                165                 170                 175     


Lys Gln Trp Leu Glu Thr Ser Gln Ser Asn Gly Leu Leu Ser Lys Ala 
            180                 185                 190         


Thr Leu Asp Glu Ser Thr Lys Thr Val His Leu Gly Tyr Ser Tyr Gln 
        195                 200                 205             


Glu Leu Gln Asp Leu Thr Gly Ala Glu Ser Val Gln Met Ala Phe Tyr 
    210                 215                 220                 


Phe Leu Lys Glu Ala Ala Lys Lys Ala Asp Pro Ile Ser Gly Asp Ser 
225                 230                 235                 240 


Ala Glu Met Ile Leu Leu Lys Lys Phe Ala Asp Gln Ser Tyr Leu Ser 
                245                 250                 255     


Gln Leu Asp Ser Asp Arg Met Asp Gln Ile Glu Gly Ile Tyr Arg Ser 
            260                 265                 270         


Ser His Glu Thr Asp Ile Asp Ala Trp Asp Arg Arg Tyr Ser Gly Thr 
        275                 280                 285             


Gly Tyr Asp Glu Leu Thr Asn Lys Leu Ala Ser Ala Thr Gly Val Asp 
    290                 295                 300                 


Glu Gln Leu Ala Val Leu Leu Asp Asp Arg Lys Gly Leu Leu Ile Gly 
305                 310                 315                 320 


Glu Val His Gly Ser Asp Val Asn Gly Leu Arg Phe Val Asn Glu Gln 
                325                 330                 335     


Met Asp Ala Leu Lys Lys Gln Gly Val Thr Val Ile Gly Leu Glu His 
            340                 345                 350         


Leu Arg Ser Asp Leu Ala Gln Pro Leu Ile Asp Arg Tyr Leu Ala Thr 
        355                 360                 365             


Gly Val Met Ser Ser Glu Leu Ser Ala Met Leu Lys Thr Lys His Leu 
    370                 375                 380                 


Asp Val Thr Leu Phe Glu Asn Ala Arg Ala Asn Gly Met Arg Ile Val 
385                 390                 395                 400 


Ala Leu Asp Ala Asn Ser Ser Ala Arg Pro Asn Val Gln Gly Thr Glu 
                405                 410                 415     


His Gly Leu Met Tyr Arg Ala Gly Ala Ala Asn Asn Ile Ala Val Glu 
            420                 425                 430         


Val Leu Gln Asn Leu Pro Asp Gly Glu Lys Phe Val Ala Ile Tyr Gly 
        435                 440                 445             


Lys Ala His Leu Gln Ser His Lys Gly Ile Glu Gly Phe Val Pro Gly 
    450                 455                 460                 


Ile Thr His Arg Leu Asp Leu Pro Ala Leu Lys Val Ser Asp Ser Asn 
465                 470                 475                 480 


Gln Phe Thr Val Glu Gln Asp Asp Val Ser Leu Arg Val Val Tyr Asp 
                485                 490                 495     


Asp Val Ala Asn Lys Pro Lys Ile Thr Phe Lys Gly Ser Leu 
            500                 505                 510 


<210>  2
<211>  186
<212>  PRT
<213>  Vibrio vulnificus

<400>  2

Phe Ile Gly Lys Met Gln Val Ala Gln Ala Gly Ile Asp Ala Ile Ala 
1               5                   10                  15      


Gln Thr Arg Pro Glu Leu Ala Ala Arg Ile Phe Met Val Ala Ile Glu 
            20                  25                  30          


Glu Ala Asn Gly Lys His Val Gly Leu Thr Asp Met Met Val Arg Trp 
        35                  40                  45              


Ala Asn Glu Asp Pro Tyr Leu Ala Pro Lys His Gly Tyr Lys Gly Glu 
    50                  55                  60                  


Thr Pro Ser Asp Leu Gly Phe Asp Ala Lys Tyr His Val Asp Leu Gly 
65                  70                  75                  80  


Glu His Tyr Ala Asp Phe Lys Gln Trp Leu Glu Thr Ser Gln Ser Asn 
                85                  90                  95      


Gly Leu Leu Ser Lys Ala Thr Leu Asp Glu Ser Thr Lys Thr Val His 
            100                 105                 110         


Leu Gly Tyr Ser Tyr Gln Glu Leu Gln Asp Leu Thr Gly Ala Glu Ser 
        115                 120                 125             


Val Gln Met Ala Phe Tyr Phe Leu Lys Glu Ala Ala Lys Lys Ala Asp 
    130                 135                 140                 


Pro Ile Ser Gly Asp Ser Ala Glu Met Ile Leu Leu Lys Lys Phe Ala 
145                 150                 155                 160 


Asp Gln Ser Tyr Leu Ser Gln Leu Asp Ser Asp Arg Met Asp Gln Ile 
                165                 170                 175     


Glu Gly Ile Tyr Arg Ser Ser His Glu Thr 
            180                 185     


<210>  3
<211>  510
<212>  PRT
<213>  Vibrio harveyi

<400>  3

Gly Asp Lys Thr Lys Val Val Val Asp Leu Ala Gln Ile Phe Thr Val 
1               5                   10                  15      


Gln Glu Leu Lys Glu Arg Ala Lys Val Phe Ala Lys Pro Ile Gly Ala 
            20                  25                  30          


Ser Tyr Gln Gly Ile Leu Asp Gln Leu Asp Leu Val His Gln Ala Lys 
        35                  40                  45              


Gly Arg Asp Gln Ile Ala Ala Ser Phe Glu Leu Asn Lys Lys Ile Asn 
    50                  55                  60                  


Asp Tyr Ile Ala Glu His Pro Thr Ser Gly Arg Asn Gln Ala Leu Thr 
65                  70                  75                  80  


Gln Leu Lys Glu Gln Val Thr Ser Ala Leu Phe Ile Gly Lys Met Gln 
                85                  90                  95      


Val Ala Gln Ala Gly Ile Asp Ala Ile Ala Gln Thr Arg Pro Glu Leu 
            100                 105                 110         


Ala Ala Arg Ile Phe Met Val Ala Ile Glu Glu Ala Asn Gly Lys His 
        115                 120                 125             


Val Gly Leu Thr Asp Met Met Val Arg Trp Ala Asn Glu Asp Pro Tyr 
    130                 135                 140                 


Leu Ala Pro Lys His Gly Tyr Lys Gly Glu Thr Pro Ser Asp Leu Gly 
145                 150                 155                 160 


Phe Asp Ala Lys Tyr His Val Asp Leu Gly Glu His Tyr Ala Asp Phe 
                165                 170                 175     


Lys Gln Trp Leu Glu Thr Ser Gln Ser Asn Gly Leu Leu Ser Lys Ala 
            180                 185                 190         


Thr Leu Asp Glu Ser Thr Lys Thr Val His Leu Gly Tyr Ser Tyr Gln 
        195                 200                 205             


Glu Leu Gln Asp Leu Thr Gly Ala Glu Ser Val Gln Met Ala Phe Tyr 
    210                 215                 220                 


Phe Leu Lys Glu Ala Ala Lys Lys Ala Asp Pro Ile Ser Gly Asp Ser 
225                 230                 235                 240 


Val Glu Met Ile Leu Leu Lys Lys Phe Ala Asp Gln Ser Tyr Leu Ser 
                245                 250                 255     


Gln Leu Asp Ser Asp Arg Met Asp Gln Ile Glu Gly Ile Tyr Arg Ser 
            260                 265                 270         


Ser His Glu Thr Asp Ile Asp Ala Trp Asp Arg Arg Tyr Ser Gly Thr 
        275                 280                 285             


Gly Tyr Asp Glu Leu Thr Asn Lys Leu Ala Ser Ala Thr Gly Val Asp 
    290                 295                 300                 


Glu Gln Leu Ala Val Leu Leu Asp Asp Arg Lys Gly Leu Leu Ile Gly 
305                 310                 315                 320 


Glu Val His Gly Ser Asp Val Asn Gly Leu Arg Phe Val Asn Glu Gln 
                325                 330                 335     


Met Asp Ala Leu Lys Lys Gln Gly Val Thr Val Ile Gly Leu Glu His 
            340                 345                 350         


Leu Arg Ser Asp Leu Ala Gln Pro Leu Ile Asp Arg Tyr Leu Ala Thr 
        355                 360                 365             


Gly Val Met Ser Ser Glu Leu Ser Ala Met Leu Lys Thr Lys His Leu 
    370                 375                 380                 


Asp Val Thr Leu Phe Glu Asn Ala Arg Ala Asn Gly Met Arg Ile Val 
385                 390                 395                 400 


Ala Leu Asp Ala Asn Ser Ser Ala Arg Pro Asn Val Gln Gly Thr Glu 
                405                 410                 415     


His Gly Leu Met Tyr Arg Ala Gly Ala Ala Asn Asn Ile Ala Val Glu 
            420                 425                 430         


Val Leu Gln Asn Leu Pro Asp Gly Glu Lys Phe Val Ala Ile Tyr Gly 
        435                 440                 445             


Lys Ala His Leu Gln Ser His Lys Gly Ile Glu Gly Phe Val Pro Gly 
    450                 455                 460                 


Ile Thr His Arg Leu Asp Leu Pro Ala Leu Lys Val Ser Asp Ser Asn 
465                 470                 475                 480 


Gln Phe Thr Val Glu Gln Asp Asp Val Ser Leu Arg Val Val Tyr Asp 
                485                 490                 495     


Asp Val Ala Asn Lys Pro Lys Ile Thr Phe Lys Asp Ser Leu 
            500                 505                 510 


<210>  4
<211>  186
<212>  PRT
<213>  Vibrio harveyi

<400>  4

Phe Ile Gly Lys Met Gln Val Ala Gln Ala Gly Ile Asp Ala Ile Ala 
1               5                   10                  15      


Gln Thr Arg Pro Glu Leu Ala Ala Arg Ile Phe Met Val Ala Ile Glu 
            20                  25                  30          


Glu Ala Asn Gly Lys His Val Gly Leu Thr Asp Met Met Val Arg Trp 
        35                  40                  45              


Ala Asn Glu Asp Pro Tyr Leu Ala Pro Lys His Gly Tyr Lys Gly Glu 
    50                  55                  60                  


Thr Pro Ser Asp Leu Gly Phe Asp Ala Lys Tyr His Val Asp Leu Gly 
65                  70                  75                  80  


Glu His Tyr Ala Asp Phe Lys Gln Trp Leu Glu Thr Ser Gln Ser Asn 
                85                  90                  95      


Gly Leu Leu Ser Lys Ala Thr Leu Asp Glu Ser Thr Lys Thr Val His 
            100                 105                 110         


Leu Gly Tyr Ser Tyr Gln Glu Leu Gln Asp Leu Thr Gly Ala Glu Ser 
        115                 120                 125             


Val Gln Met Ala Phe Tyr Phe Leu Lys Glu Ala Ala Lys Lys Ala Asp 
    130                 135                 140                 


Pro Ile Ser Gly Asp Ser Val Glu Met Ile Leu Leu Lys Lys Phe Ala 
145                 150                 155                 160 


Asp Gln Ser Tyr Leu Ser Gln Leu Asp Ser Asp Arg Met Asp Gln Ile 
                165                 170                 175     


Glu Gly Ile Tyr Arg Ser Ser His Glu Thr 
            180                 185     


<210>  5
<211>  510
<212>  PRT
<213>  Vibrio ordalii

<400>  5

Gly Asp Lys Thr Lys Val Val Val Asp Leu Ala Gln Ile Phe Thr Val 
1               5                   10                  15      


Gln Glu Leu Lys Glu Arg Ala Lys Val Phe Ala Lys Pro Ile Gly Ala 
            20                  25                  30          


Ser Tyr Gln Gly Ile Leu Asp Gln Leu Asp Leu Val His Gln Ala Lys 
        35                  40                  45              


Gly Arg Asp Gln Ile Ala Ala Ser Phe Glu Leu Asn Lys Lys Ile Asn 
    50                  55                  60                  


Ala Tyr Ile Ala Glu His Pro Thr Ser Gly Arg Asn Gln Ala Leu Thr 
65                  70                  75                  80  


Gln Leu Lys Glu Gln Val Thr Ser Ala Leu Phe Ile Gly Lys Met Gln 
                85                  90                  95      


Ile Ala Gln Ala Gly Ile Asp Ala Ile Ala Gln Thr Arg Pro Glu Leu 
            100                 105                 110         


Ala Ala Arg Ile Phe Met Val Ala Ile Glu Glu Ala Asn Gly Lys His 
        115                 120                 125             


Val Gly Leu Thr Asp Met Met Val Arg Trp Ala Asn Glu Asp Pro Tyr 
    130                 135                 140                 


Leu Ala Pro Lys His Gly Tyr Lys Gly Glu Thr Pro Ser Asp Leu Gly 
145                 150                 155                 160 


Phe Asp Ala Lys Tyr His Val Asp Leu Ser Glu His Tyr Ala Asp Phe 
                165                 170                 175     


Lys Gln Trp Leu Glu Thr Ser Gln Ser Asn Gly Leu Leu Ser Lys Ala 
            180                 185                 190         


Met Leu Asp Glu Ser Thr Lys Thr Val His Leu Gly Tyr Ser Tyr Gln 
        195                 200                 205             


Glu Leu Gln Asp Leu Thr Gly Val Glu Ser Val Gln Met Ala Phe Tyr 
    210                 215                 220                 


Phe Leu Lys Glu Ala Ala Lys Lys Ala Asp Pro Ile Ser Gly Asp Ser 
225                 230                 235                 240 


Ala Glu Met Ile Leu Leu Lys Lys Phe Ala Asp Gln Ser Tyr Leu Ser 
                245                 250                 255     


Gln Leu Asp Ser Asp Arg Met Asp Gln Ile Glu Gly Ile Tyr Arg Ser 
            260                 265                 270         


Ser His Glu Thr Asp Val Asp Ala Trp Asp Arg Arg Tyr Ser Gly Lys 
        275                 280                 285             


Gly Tyr Asp Glu Leu Thr Asn Lys Leu Ala Ser Ala Thr Gly Val Asp 
    290                 295                 300                 


Glu Gln Leu Ser Val Leu Leu Asp Asp Arg Lys Gly Leu Leu Ile Gly 
305                 310                 315                 320 


Glu Val His Gly Ser Asp Val Asn Gly Leu Arg Phe Val Asn Glu Gln 
                325                 330                 335     


Met Asp Ala Leu Lys Lys Gln Gly Val Thr Val Ile Gly Leu Glu His 
            340                 345                 350         


Leu Arg Ser Asp Leu Ala Gln Pro Leu Ile Asp Arg Tyr Leu Ala Thr 
        355                 360                 365             


Gly Val Met Ser Ser Glu Leu Ser Ala Met Leu Lys Thr Lys His Leu 
    370                 375                 380                 


Asp Val Ala Leu Phe Glu Asn Ala Arg Ala His Gly Met Arg Ile Val 
385                 390                 395                 400 


Ala Leu Asp Ala Asn Ser Ser Ala Arg Pro Asn Val Gln Gly Thr Glu 
                405                 410                 415     


His Gly Leu Met Tyr Arg Ala Gly Ala Ala Asn Asn Ile Ala Val Glu 
            420                 425                 430         


Val Leu Gln Asn Leu Pro Asp Gly Glu Lys Phe Val Ala Ile Tyr Gly 
        435                 440                 445             


Lys Ala His Leu Gln Ser His Lys Gly Ile Glu Gly Phe Val Pro Gly 
    450                 455                 460                 


Ile Thr His Arg Leu Asp Leu Pro Ala Leu Lys Val Ser Asp Ser Asn 
465                 470                 475                 480 


Gln Phe Thr Val Glu Gln Asp Asp Val Ser Leu Arg Val Val Tyr Asp 
                485                 490                 495     


Asp Val Ala Asn Lys Pro Lys Ile Thr Phe Lys Asp Ser Leu 
            500                 505                 510 


<210>  6
<211>  186
<212>  PRT
<213>  Vibrio ordalii

<400>  6

Phe Ile Gly Lys Met Gln Ile Ala Gln Ala Gly Ile Asp Ala Ile Ala 
1               5                   10                  15      


Gln Thr Arg Pro Glu Leu Ala Ala Arg Ile Phe Met Val Ala Ile Glu 
            20                  25                  30          


Glu Ala Asn Gly Lys His Val Gly Leu Thr Asp Met Met Val Arg Trp 
        35                  40                  45              


Ala Asn Glu Asp Pro Tyr Leu Ala Pro Lys His Gly Tyr Lys Gly Glu 
    50                  55                  60                  


Thr Pro Ser Asp Leu Gly Phe Asp Ala Lys Tyr His Val Asp Leu Ser 
65                  70                  75                  80  


Glu His Tyr Ala Asp Phe Lys Gln Trp Leu Glu Thr Ser Gln Ser Asn 
                85                  90                  95      


Gly Leu Leu Ser Lys Ala Met Leu Asp Glu Ser Thr Lys Thr Val His 
            100                 105                 110         


Leu Gly Tyr Ser Tyr Gln Glu Leu Gln Asp Leu Thr Gly Val Glu Ser 
        115                 120                 125             


Val Gln Met Ala Phe Tyr Phe Leu Lys Glu Ala Ala Lys Lys Ala Asp 
    130                 135                 140                 


Pro Ile Ser Gly Asp Ser Ala Glu Met Ile Leu Leu Lys Lys Phe Ala 
145                 150                 155                 160 


Asp Gln Ser Tyr Leu Ser Gln Leu Asp Ser Asp Arg Met Asp Gln Ile 
                165                 170                 175     


Glu Gly Ile Tyr Arg Ser Ser His Glu Thr 
            180                 185     


<210>  7
<211>  511
<212>  PRT
<213>  Vibrio cholerae

<400>  7

Ser Gly Asn Lys Ala Lys Val Ala Val Asp Leu Ala Gln Ile Phe Thr 
1               5                   10                  15      


Val Gln Glu Leu Lys Glu Arg Ala Lys Val Phe Ala Lys Pro Ile Gly 
            20                  25                  30          


Ala Ser Tyr Gln Gly Ile Leu Asp Gln Leu Asp Leu Val His Gln Ala 
        35                  40                  45              


Lys Gly Arg Tyr Gln Ile Ala Ala Ser Phe Glu Leu Asn Lys Lys Ile 
    50                  55                  60                  


Asn Asp Tyr Ile Ala Glu His Pro Thr Ser Gly Arg Asn Gln Ala Leu 
65                  70                  75                  80  


Thr Gln Leu Lys Glu Gln Val Thr Ser Ala Leu Phe Ile Gly Lys Met 
                85                  90                  95      


Gln Val Ala Gln Ala Gly Ile Asp Ala Ile Ala Gln Thr Arg Pro Glu 
            100                 105                 110         


Leu Ala Thr Arg Ile Phe Met Val Ala Ile Glu Glu Ala Asn Gly Lys 
        115                 120                 125             


His Val Gly Leu Thr Asp Met Met Leu Arg Trp Ala Asn Glu Asp Pro 
    130                 135                 140                 


Tyr Leu Ala Pro Lys His Gly Tyr Lys Gly Glu Met Pro Ser Asp Leu 
145                 150                 155                 160 


Gly Phe Asp Ala Lys Tyr His Val Asp Leu Gly Glu His Tyr Ala Asp 
                165                 170                 175     


Phe Lys Gln Trp Leu Glu Thr Ser Gln Ser Asn Gly Leu Leu Ser Lys 
            180                 185                 190         


Ala Thr Leu Asp Glu Ser Thr Lys Thr Val His Leu Gly Tyr Ser Tyr 
        195                 200                 205             


Gln Glu Leu Gln Asp Leu Thr Gly Ala Glu Ser Val Gln Met Ala Phe 
    210                 215                 220                 


Tyr Phe Leu Lys Glu Ala Ala Lys Lys Ala Asp Pro Ile Ser Gly Asp 
225                 230                 235                 240 


Ser Ala Glu Met Ile Leu Leu Lys Lys Phe Ala Asp Gln Asn Tyr Leu 
                245                 250                 255     


Ser Gln Leu Asp Ser Asp Arg Met Asp Gln Ile Glu Gly Ile Tyr Arg 
            260                 265                 270         


Ser Ser His Glu Thr Asp Val Asp Ala Trp Asp Arg Arg Tyr Ser Gly 
        275                 280                 285             


Lys Gly Tyr Asp Glu Leu Thr Asn Met Leu Ala Ser Ala Thr Gly Val 
    290                 295                 300                 


Asp Glu Gln Leu Ser Val Leu Leu Asp Asp Arg Lys Gly Leu Leu Ile 
305                 310                 315                 320 


Gly Glu Val His Gly Ser Asp Val Asn Gly Leu Arg Phe Val Asn Glu 
                325                 330                 335     


Gln Met Glu Ala Leu Lys Lys Gln Gly Val Thr Val Ile Gly Leu Glu 
            340                 345                 350         


His Leu Arg Ser Asp Leu Ala Gln Pro Leu Ile Asp Arg Tyr Leu Ala 
        355                 360                 365             


Thr Gly Val Met Ser Ser Glu Leu Ser Ala Met Leu Lys Thr Lys His 
    370                 375                 380                 


Leu Asp Val Thr Leu Phe Glu Asn Ala Arg Val Asn Gly Met Arg Ile 
385                 390                 395                 400 


Val Ala Leu Asp Ala Asn Ser Ser Ala Arg Pro Asn Val Gln Gly Thr 
                405                 410                 415     


Glu His Gly Leu Met Tyr Arg Ala Gly Ala Ala Asn Asn Ile Ala Val 
            420                 425                 430         


Glu Val Leu Gln Asn Leu Pro Asp Gly Glu Lys Phe Val Ala Ile Tyr 
        435                 440                 445             


Gly Lys Ala His Leu Gln Ser His Lys Gly Ile Glu Gly Phe Val Pro 
    450                 455                 460                 


Gly Ile Thr His Arg Leu Asp Leu Pro Ala Leu Lys Val Ser Asp Ser 
465                 470                 475                 480 


Asn Gln Phe Thr Val Glu Gln Asp Asp Val Ser Leu Arg Val Val Tyr 
                485                 490                 495     


Asp Asp Val Ala Asn Lys Pro Lys Ile Thr Phe Lys Gly Ser Leu 
            500                 505                 510     


<210>  8
<211>  186
<212>  PRT
<213>  Vibrio cholerae

<400>  8

Phe Ile Gly Lys Met Gln Val Ala Gln Ala Gly Ile Asp Ala Ile Ala 
1               5                   10                  15      


Gln Thr Arg Pro Glu Leu Ala Thr Arg Ile Phe Met Val Ala Ile Glu 
            20                  25                  30          


Glu Ala Asn Gly Lys His Val Gly Leu Thr Asp Met Met Leu Arg Trp 
        35                  40                  45              


Ala Asn Glu Asp Pro Tyr Leu Ala Pro Lys His Gly Tyr Lys Gly Glu 
    50                  55                  60                  


Met Pro Ser Asp Leu Gly Phe Asp Ala Lys Tyr His Val Asp Leu Gly 
65                  70                  75                  80  


Glu His Tyr Ala Asp Phe Lys Gln Trp Leu Glu Thr Ser Gln Ser Asn 
                85                  90                  95      


Gly Leu Leu Ser Lys Ala Thr Leu Asp Glu Ser Thr Lys Thr Val His 
            100                 105                 110         


Leu Gly Tyr Ser Tyr Gln Glu Leu Gln Asp Leu Thr Gly Ala Glu Ser 
        115                 120                 125             


Val Gln Met Ala Phe Tyr Phe Leu Lys Glu Ala Ala Lys Lys Ala Asp 
    130                 135                 140                 


Pro Ile Ser Gly Asp Ser Ala Glu Met Ile Leu Leu Lys Lys Phe Ala 
145                 150                 155                 160 


Asp Gln Asn Tyr Leu Ser Gln Leu Asp Ser Asp Arg Met Asp Gln Ile 
                165                 170                 175     


Glu Gly Ile Tyr Arg Ser Ser His Glu Thr 
            180                 185     


<210>  9
<211>  511
<212>  PRT
<213>  Vibrio splendidus

<400>  9

Gly Asn Lys Thr Lys Leu Val Val Asp Leu Ser Thr Ile Met Thr Lys 
1               5                   10                  15      


Gln Glu Leu Lys Asp Gly Gly Lys Val Phe Ala Lys Pro Ile Gly Ala 
            20                  25                  30          


Ser Tyr Gln Ala Ile Leu Asp Gln Val Glu Leu Val His Ser Ser Ile 
        35                  40                  45              


Gly Arg Asp Gln Val Gly Ala Ser Phe Glu Leu Asn Lys Gln Ile Asn 
    50                  55                  60                  


Asn Tyr Leu Ala Glu His Pro Thr Ser Gly Arg Asn Leu Ala Leu Thr 
65                  70                  75                  80  


Thr Leu Lys Glu Gln Val Asn Thr Ala Leu Phe Ser Gly Lys Met Lys 
                85                  90                  95      


Val Thr Gln Glu Ser Ile Asp Ala Ile Ala Gln Thr Arg Thr Asp Leu 
            100                 105                 110         


Ala Ala Arg Ile Tyr Val Val Ala Met Glu Glu Ala Asn Gly Glu His 
        115                 120                 125             


Val Gly Leu Thr Asp Met Met Val Arg Trp Ala Asn Glu Asp Pro Tyr 
    130                 135                 140                 


Leu Ser Pro Lys Gln Gly Tyr Ala Gly Glu Thr Pro Ser Asp Leu Gly 
145                 150                 155                 160 


Phe Asp Ala Lys Tyr His Ile Glu Leu Gly Glu Gln Tyr Ser Asp Phe 
                165                 170                 175     


Lys Leu Trp Leu Glu Lys Ser Gln Ser Ala Asp Leu Leu Ser Lys Ala 
            180                 185                 190         


Ala Leu Asp Glu Ala Thr Lys Thr Val His Leu Gly Tyr Ser Tyr Gln 
        195                 200                 205             


Glu Leu Gln Asp Leu Thr Gly Val Glu Ser Val Gln Met Ala Phe Tyr 
    210                 215                 220                 


Phe Leu Lys Glu Ala Ala Lys Lys Ser Asp Ser Thr Thr Ser Asp Ser 
225                 230                 235                 240 


Ala Glu Met Ile Leu Leu Lys Lys Phe Ala Asp Gln Gly Tyr Ile Ser 
                245                 250                 255     


Gln Leu Glu Thr Asp Arg Met Asp His Ile Glu Gly Ile Tyr Arg Ser 
            260                 265                 270         


Ser His Glu Thr Asp Val Asp Asn Trp Asp Arg Arg Tyr Ser Gly Ala 
        275                 280                 285             


Gly Tyr Asp Glu Leu Ser Asp Lys Leu Ala Gly Ala Asn Gly Gly Val 
    290                 295                 300                 


Glu Glu Gln Leu Ser Val Leu Leu Asn Glu Arg Lys Gly Leu Leu Ile 
305                 310                 315                 320 


Gly Glu Val His Gly Ser Asp Val Asn Gly Leu Arg Phe Val Asn Glu 
                325                 330                 335     


Gln Met Asp Ala Leu Lys Lys Gln Gly Val Thr Val Ile Gly Leu Glu 
            340                 345                 350         


His Leu Arg Ser Asp Leu Ala Gln Pro Leu Ile Asp Asn Tyr Leu Ser 
        355                 360                 365             


Thr Gly Ile Met Ser Ser Glu Leu Ser Ala Met Ile Lys Thr Lys His 
    370                 375                 380                 


Leu Asp Ile Thr Leu Phe Glu Asn Ala Arg Ala Asn Gly Met Arg Ile 
385                 390                 395                 400 


Leu Ala Leu Asp Ala Asn Ser Thr Ala Arg Pro Thr Val Gln Gly Thr 
                405                 410                 415     


Glu His Gly Leu Met Tyr Arg Ala Gly Ala Ala Asn Asn Val Ala Val 
            420                 425                 430         


Asp Ala Leu Gln Ala Leu Pro Asp Gly Glu Lys Phe Val Ala Ile Tyr 
        435                 440                 445             


Gly Lys Ala His Leu Gln Ser His Lys Gly Ile Glu Ser Phe Val Pro 
    450                 455                 460                 


Gly Ile Thr His Arg Leu Gly Leu Pro Ala Leu Lys Val Ser Ala Ser 
465                 470                 475                 480 


Asp Gln Phe Val Ile Glu Gln Asp Asp Lys Thr Leu Arg Thr Val Tyr 
                485                 490                 495     


Asp Asp Val Ala Asn Lys Pro Lys Ile Glu Phe Arg Ala Ser Leu 
            500                 505                 510     


<210>  10
<211>  186
<212>  PRT
<213>  Vibrio splendidus

<400>  10

Phe Ser Gly Lys Met Lys Val Thr Gln Glu Ser Ile Asp Ala Ile Ala 
1               5                   10                  15      


Gln Thr Arg Thr Asp Leu Ala Ala Arg Ile Tyr Val Val Ala Met Glu 
            20                  25                  30          


Glu Ala Asn Gly Glu His Val Gly Leu Thr Asp Met Met Val Arg Trp 
        35                  40                  45              


Ala Asn Glu Asp Pro Tyr Leu Ser Pro Lys Gln Gly Tyr Ala Gly Glu 
    50                  55                  60                  


Thr Pro Ser Asp Leu Gly Phe Asp Ala Lys Tyr His Ile Glu Leu Gly 
65                  70                  75                  80  


Glu Gln Tyr Ser Asp Phe Lys Leu Trp Leu Glu Lys Ser Gln Ser Ala 
                85                  90                  95      


Asp Leu Leu Ser Lys Ala Ala Leu Asp Glu Ala Thr Lys Thr Val His 
            100                 105                 110         


Leu Gly Tyr Ser Tyr Gln Glu Leu Gln Asp Leu Thr Gly Val Glu Ser 
        115                 120                 125             


Val Gln Met Ala Phe Tyr Phe Leu Lys Glu Ala Ala Lys Lys Ser Asp 
    130                 135                 140                 


Ser Thr Thr Ser Asp Ser Ala Glu Met Ile Leu Leu Lys Lys Phe Ala 
145                 150                 155                 160 


Asp Gln Gly Tyr Ile Ser Gln Leu Glu Thr Asp Arg Met Asp His Ile 
                165                 170                 175     


Glu Gly Ile Tyr Arg Ser Ser His Glu Thr 
            180                 185     


<210>  11
<211>  510
<212>  PRT
<213>  Moritella dasanensis

<400>  11

Gly Asn Lys Ala Lys Gln Ser Ala Asp Leu Ser Glu Val Phe Thr Lys 
1               5                   10                  15      


Asp Gln Leu Lys Lys Asn Ala Lys Val Phe Ala Lys Pro Ile Gly Val 
            20                  25                  30          


Ser Tyr Gln Arg Ile Leu Asp Gln Val Gly Leu Val His Ser Thr Thr 
        35                  40                  45              


Gly Arg Asp Gln Ile Ala Ala Ser Phe Glu Leu Asn Lys Gln Ile Asp 
    50                  55                  60                  


Ala Tyr Val Glu Ala Asn Pro Ala Ser Gly Arg Asn Gln Ala Phe Asn 
65                  70                  75                  80  


Gln Leu Lys Gly Gln Ile Thr Asn Ala Leu Phe Asn Gly Asp Ile Gln 
                85                  90                  95      


Val Ala Lys Glu Gly Ile Ser Glu Ile Ala Gln Thr Arg Pro Glu Leu 
            100                 105                 110         


Ala Ala Arg Ile Tyr Ile Ile Ala Gln Glu Glu Ala Asn Gly Lys Asn 
        115                 120                 125             


Leu Gly Leu Thr Asp Leu Met Val Arg Trp Ala Lys Glu Asp Pro Tyr 
    130                 135                 140                 


Leu Ser Ala Lys Asn Gly Tyr Gln Gly Asp Ile Pro Ser Asp Leu Gly 
145                 150                 155                 160 


Phe Glu Ala Lys Phe His Val Glu Leu Gly Ser Gln Tyr Ala Asp Phe 
                165                 170                 175     


Lys Gln Thr Leu Glu Lys Ala Gln Val Glu Gly Leu Leu Thr Lys Ala 
            180                 185                 190         


Val Ile Asp Glu Ser Thr Lys Thr Val His Leu Gly Tyr Thr Tyr Gln 
        195                 200                 205             


Glu Leu Gln Asp Gln Thr Gly Thr Glu Ser Val Gln Met Ala Ala Tyr 
    210                 215                 220                 


Phe Leu Lys Glu Ala Ala Lys Lys Ser Asp Pro Thr Ser Ala Asp Ser 
225                 230                 235                 240 


Ala Glu Met Ile Leu Leu Asn Lys Phe Ala Asp Lys Asn Tyr Ile Thr 
                245                 250                 255     


Glu Leu Glu Arg Gln Arg Ile Asp Gln Ile Glu Ser Ile Tyr Arg Ser 
            260                 265                 270         


Ser His Asp Thr Asp Ile Ala Gly Trp Asp Lys Arg Tyr Ser Gly Thr 
        275                 280                 285             


Ala Leu Asn Glu Leu Asn Ser Gln Leu Gly Ala Ala Thr Ser Val Glu 
    290                 295                 300                 


Ala Gln Leu Ala Leu Leu Leu Glu Lys Arg Asn Gly Leu Leu Ile Gly 
305                 310                 315                 320 


Glu Ser His Gly Ser Asp Val Asn Gly Leu Arg Phe Val Asn Glu Gln 
                325                 330                 335     


Met Asp Ala Leu Lys Ala Gln Gly Val Ser Val Ile Gly Leu Glu His 
            340                 345                 350         


Leu Arg Ala Asp Leu Ala Gln Pro Leu Ile Asp Ser Tyr Leu Ser Ser 
        355                 360                 365             


Gly Asp Met Ser Ser Glu Leu Arg Ile Met Leu Lys Thr Lys His Leu 
    370                 375                 380                 


Asp Ile Ser Leu Phe Glu Asn Ala Arg Ala Lys Gly Leu Arg Ile Val 
385                 390                 395                 400 


Ala Leu Asp Ala Asn Ser Thr Thr Arg Pro Thr Ile Gln Gly Thr Glu 
                405                 410                 415     


His Gly Leu Met Tyr Arg Ala Gly Ala Ala Asn Asn Val Ala Val Glu 
            420                 425                 430         


Thr Leu Ser Gly Leu Pro Ala Gly Glu Lys Phe Val Ala Ile Tyr Gly 
        435                 440                 445             


Asn Ala His Leu Gln Ser His Lys Gly Ile Glu Gly Phe Val Pro Gly 
    450                 455                 460                 


Ile Thr His Arg Leu Asp Leu Pro Gly Leu Lys Ile Ser Glu Thr Asn 
465                 470                 475                 480 


Gln Phe Lys Ala Gln Ala Asp Asp Leu Ser Gln Arg Val Ile Tyr Gly 
                485                 490                 495     


Asp Val Leu Asn Lys Ala Lys Ile Glu Phe Thr Asn Ser Leu 
            500                 505                 510 


<210>  12
<211>  186
<212>  PRT
<213>  Moritella dasanensis

<400>  12

Phe Asn Gly Asp Ile Gln Val Ala Lys Glu Gly Ile Ser Glu Ile Ala 
1               5                   10                  15      


Gln Thr Arg Pro Glu Leu Ala Ala Arg Ile Tyr Ile Ile Ala Gln Glu 
            20                  25                  30          


Glu Ala Asn Gly Lys Asn Leu Gly Leu Thr Asp Leu Met Val Arg Trp 
        35                  40                  45              


Ala Lys Glu Asp Pro Tyr Leu Ser Ala Lys Asn Gly Tyr Gln Gly Asp 
    50                  55                  60                  


Ile Pro Ser Asp Leu Gly Phe Glu Ala Lys Phe His Val Glu Leu Gly 
65                  70                  75                  80  


Ser Gln Tyr Ala Asp Phe Lys Gln Thr Leu Glu Lys Ala Gln Val Glu 
                85                  90                  95      


Gly Leu Leu Thr Lys Ala Val Ile Asp Glu Ser Thr Lys Thr Val His 
            100                 105                 110         


Leu Gly Tyr Thr Tyr Gln Glu Leu Gln Asp Gln Thr Gly Thr Glu Ser 
        115                 120                 125             


Val Gln Met Ala Ala Tyr Phe Leu Lys Glu Ala Ala Lys Lys Ser Asp 
    130                 135                 140                 


Pro Thr Ser Ala Asp Ser Ala Glu Met Ile Leu Leu Asn Lys Phe Ala 
145                 150                 155                 160 


Asp Lys Asn Tyr Ile Thr Glu Leu Glu Arg Gln Arg Ile Asp Gln Ile 
                165                 170                 175     


Glu Ser Ile Tyr Arg Ser Ser His Asp Thr 
            180                 185     


<210>  13
<211>  509
<212>  PRT
<213>  Aeromonas salmonicida

<400>  13

Pro Gly Lys Val Val Ala Gln Glu Arg Ala Ser Ser Leu Phe Ala Asp 
1               5                   10                  15      


Ala Tyr Ser Pro Asp Glu Leu Lys Lys Ala Ala Gln Val Phe Ala Lys 
            20                  25                  30          


Pro Ile Gly Glu Ser Tyr Gln Gly Ile Leu Asp Gln Leu Ala Val Leu 
        35                  40                  45              


His Gly Ala Thr Gly Gln Val Gln Val Glu Ala Ala Leu Arg Leu Asn 
    50                  55                  60                  


Lys Leu Ile Asp Asp Tyr Gln Ala Arg His Glu Gly Ser Gly Arg Asn 
65                  70                  75                  80  


Pro Ala Leu Ser Lys Leu Gln Ser Gln Leu Asn Gly Gly Leu Tyr His 
                85                  90                  95      


Gly Glu Leu Ala Ser Leu Gln Ala Asp Val Ala Ala Leu Ala Lys Ser 
            100                 105                 110         


Arg Pro Asp Leu Ala Ala Leu Val Ile Gly Lys Ala Ala Glu Glu Ala 
        115                 120                 125             


Lys Gly Gln His Pro Gly Leu Thr Gln Met Leu Leu Arg Trp Ala Ala 
    130                 135                 140                 


Gln Asp Pro Tyr Leu Ala Ala Lys Gly Gly Tyr Gln Gly Gln Ala Pro 
145                 150                 155                 160 


Ala Asp Leu Pro Phe Asp Ala Ser Phe His Val Val Leu Gly Glu Gln 
                165                 170                 175     


Tyr Gly Glu Leu Lys Arg Trp Leu Ala Asp Ala Gln Ser Lys Gly Leu 
            180                 185                 190         


Leu Ser Lys Ala Val Leu Asp Glu Thr Gly Lys Val Leu His Leu Gly 
        195                 200                 205             


Tyr Ser Tyr Gln Glu Leu Gln Asp Met Thr Gly Asp Gln Ser Ala Gln 
    210                 215                 220                 


Met Thr Val Tyr Phe Ile Lys Glu Ala Ala Lys Gln Ala Ala Pro Gly 
225                 230                 235                 240 


Ser Glu Leu Ser Ala Glu Met Ile Met Leu Asp Lys Phe Ala Asp Arg 
                245                 250                 255     


Arg Tyr Leu Gly Glu Leu Gly Ser Arg Arg Leu Glu Gln Val Glu Ser 
            260                 265                 270         


Ile Tyr Arg Ser Ser Lys Gln Thr Asp Val Ala Ala Trp Asp Ala Arg 
        275                 280                 285             


Tyr Ala Gly Asn Ala Leu Arg Asp Leu Asn Asp Gln Val Ala Gln Glu 
    290                 295                 300                 


Ser Thr Leu Ala Gly Gln Leu Ser Arg Leu Leu Glu Asn Arg Asn Gly 
305                 310                 315                 320 


Leu Leu Ile Gly Glu Thr His Gly Ser Asp Val Asn Gly Leu Arg Phe 
                325                 330                 335     


Val Asn Glu Gln Met Asp Val Leu Lys Ala Gln Gly Val Thr Val Ile 
            340                 345                 350         


Gly Leu Glu His Leu Arg Gly Glu Leu Ala Gln Pro Leu Ile Asp Arg 
        355                 360                 365             


Tyr Leu Ala Gly Gly Asp Met Ser Pro Glu Leu Ala Thr Met Leu Lys 
    370                 375                 380                 


Thr Lys His Leu Asp Pro Ser Leu Phe Glu Arg Ala Arg Glu Lys Gly 
385                 390                 395                 400 


Leu Arg Ile Val Ala Leu Asp Asp Gly Ser Thr Ala Arg Pro Ala Ile 
                405                 410                 415     


Ala Gly Thr Glu His Gly Leu Met Tyr Arg Ala Gly Ala Ala Asn Asn 
            420                 425                 430         


Val Ala Val Asp Val Leu Gly Lys Leu Pro Ala Gly Glu Lys Phe Val 
        435                 440                 445             


Ala Ile Tyr Gly Ser Ala His Leu Ala Ser His Lys Gly Ile Glu Gly 
    450                 455                 460                 


Phe Val Pro Gly Ile Thr His Arg Leu Gly Leu Pro Ala Leu Lys Val 
465                 470                 475                 480 


Asp Ala Asp Asn Arg Phe Arg Leu Gln Glu Asp Asp Thr Ser Gln Arg 
                485                 490                 495     


Val Glu Tyr Gly Asp Val Ala Arg Lys Trp Thr Pro Leu 
            500                 505                 


<210>  14
<211>  186
<212>  PRT
<213>  Aeromonas salmonicida

<400>  14

Tyr His Gly Glu Leu Ala Ser Leu Gln Ala Asp Val Ala Ala Leu Ala 
1               5                   10                  15      


Lys Ser Arg Pro Asp Leu Ala Ala Leu Val Ile Gly Lys Ala Ala Glu 
            20                  25                  30          


Glu Ala Lys Gly Gln His Pro Gly Leu Thr Gln Met Leu Leu Arg Trp 
        35                  40                  45              


Ala Ala Gln Asp Pro Tyr Leu Ala Ala Lys Gly Gly Tyr Gln Gly Gln 
    50                  55                  60                  


Ala Pro Ala Asp Leu Pro Phe Asp Ala Ser Phe His Val Val Leu Gly 
65                  70                  75                  80  


Glu Gln Tyr Gly Glu Leu Lys Arg Trp Leu Ala Asp Ala Gln Ser Lys 
                85                  90                  95      


Gly Leu Leu Ser Lys Ala Val Leu Asp Glu Thr Gly Lys Val Leu His 
            100                 105                 110         


Leu Gly Tyr Ser Tyr Gln Glu Leu Gln Asp Met Thr Gly Asp Gln Ser 
        115                 120                 125             


Ala Gln Met Thr Val Tyr Phe Ile Lys Glu Ala Ala Lys Gln Ala Ala 
    130                 135                 140                 


Pro Gly Ser Glu Leu Ser Ala Glu Met Ile Met Leu Asp Lys Phe Ala 
145                 150                 155                 160 


Asp Arg Arg Tyr Leu Gly Glu Leu Gly Ser Arg Arg Leu Glu Gln Val 
                165                 170                 175     


Glu Ser Ile Tyr Arg Ser Ser Lys Gln Thr 
            180                 185     


<210>  15
<211>  512
<212>  PRT
<213>  Aeromonas hydrophila

<400>  15

Pro Gly Lys Thr Gly Val Thr Glu Arg Thr Ala Arg Leu Phe Ala Asp 
1               5                   10                  15      


Val Tyr Ser Pro Asp Glu Leu Lys Lys Ala Ala Gln Val Phe Ala Lys 
            20                  25                  30          


Pro Ile Gly Glu Ser Tyr Gln Gln Ile Leu Asp Gln Leu Ala Thr Leu 
        35                  40                  45              


His Gly Ala Ser Gly Gln Ala Lys Val Glu Ala Ala Leu Arg Leu Asn 
    50                  55                  60                  


Asn Leu Ile Asp Asp Tyr Leu Val Lys His Glu Gly Ser Gly Arg Asn 
65                  70                  75                  80  


Pro Ala Leu Ser Lys Leu Gln Ser Gln Leu His Gly Asn Leu Tyr Arg 
                85                  90                  95      


Gly Glu Leu Ala Ser Leu Gln Ala Glu Val Thr Ala Leu Ala Lys Thr 
            100                 105                 110         


Arg Pro Asp Leu Ala Ala Ile Val Ile Gly Lys Ala Ala Glu Glu Ala 
        115                 120                 125             


Gln Gly Gln His Pro Gly Leu Thr Gln Met Val Leu Arg Trp Ala Ala 
    130                 135                 140                 


Gln Asp Pro Tyr Leu Ala Ala Lys Ala Gly Tyr Gln Gly Val Val Pro 
145                 150                 155                 160 


Ala Asp Leu Pro Phe Asp Ala Arg Phe His Ile Ala Leu Gly Glu Gln 
                165                 170                 175     


His Asp Asp Leu Lys Lys Trp Leu Thr Glu Ala Gln Gly Lys Gly Leu 
            180                 185                 190         


Leu Asn Arg Ala Val Leu Asp Asp Thr Arg Lys Val Leu His Leu Gly 
        195                 200                 205             


Tyr Ser Tyr Gln Glu Leu Gln Asp Met Thr Gly Glu Gln Ser Ala Gln 
    210                 215                 220                 


Met Ala Val Tyr Phe Ile Lys Glu Ala Ala Lys Gln Ala Ala Pro Gly 
225                 230                 235                 240 


Ser Glu Leu Ser Ala Glu Leu Ile Met Leu Asp Lys Phe Gly Asp Arg 
                245                 250                 255     


Arg Tyr Leu Gly Glu Leu Glu Ser Arg Arg Ile Ala Gln Ile Glu Asn 
            260                 265                 270         


Ile Tyr His Ser Ser Lys Gln Thr Asp Val Ala Ala Trp Asp Ala Arg 
        275                 280                 285             


Tyr Gly Gly Asp Ala Leu Arg Thr Leu Asn Asn Gln Leu Asp Gly Glu 
    290                 295                 300                 


Ser Thr Leu Ala Gly Gln Leu Ser Arg Leu Leu Asp Asn Arg Asn Gly 
305                 310                 315                 320 


Leu Leu Ile Gly Glu Thr His Gly Ser Asp Val Asn Gly Leu Arg Phe 
                325                 330                 335     


Val Asn Glu Gln Met Asp Ala Leu Lys Ile Gln Gly Val Thr Val Ile 
            340                 345                 350         


Ala Leu Glu His Leu Arg Ser Glu Leu Ala Gln Pro Leu Ile Asp Arg 
        355                 360                 365             


Tyr Leu Ala Gly Gly Glu Met Ser Pro Glu Leu Thr Ser Met Leu Lys 
    370                 375                 380                 


Asn Lys His Leu Glu Pro Ser Leu Phe Glu Arg Ala Arg Glu Arg Gly 
385                 390                 395                 400 


Met Arg Ile Val Ala Leu Asp Asp Gly Ser Thr Ala Arg Pro Ala Ile 
                405                 410                 415     


Ala Gly Thr Glu His Gly Leu Met Tyr Arg Ala Gly Ala Ala Asn Asn 
            420                 425                 430         


Val Ala Val Glu Val Leu Gly Lys Leu Pro Ala Gly Glu Lys Phe Val 
        435                 440                 445             


Ala Ile Tyr Gly Ser Ala His Leu Gly Ser His Lys Gly Ile Glu Gly 
    450                 455                 460                 


Phe Val Pro Gly Ile Thr His Arg Leu Gly Leu Pro Ala Leu Lys Val 
465                 470                 475                 480 


Asp Ala Asp Asn Arg Phe His Leu Gln Ala Asp Asp Val Ser Gln Arg 
                485                 490                 495     


Val Glu Tyr Ala Asp Val Gly Arg Lys Trp Thr Pro Val Ala Ala Leu 
            500                 505                 510         


<210>  16
<211>  186
<212>  PRT
<213>  Aeromonas hydrophila

<400>  16

Tyr Arg Gly Glu Leu Ala Ser Leu Gln Ala Glu Val Thr Ala Leu Ala 
1               5                   10                  15      


Lys Thr Arg Pro Asp Leu Ala Ala Ile Val Ile Gly Lys Ala Ala Glu 
            20                  25                  30          


Glu Ala Gln Gly Gln His Pro Gly Leu Thr Gln Met Val Leu Arg Trp 
        35                  40                  45              


Ala Ala Gln Asp Pro Tyr Leu Ala Ala Lys Ala Gly Tyr Gln Gly Val 
    50                  55                  60                  


Val Pro Ala Asp Leu Pro Phe Asp Ala Arg Phe His Ile Ala Leu Gly 
65                  70                  75                  80  


Glu Gln His Asp Asp Leu Lys Lys Trp Leu Thr Glu Ala Gln Gly Lys 
                85                  90                  95      


Gly Leu Leu Asn Arg Ala Val Leu Asp Asp Thr Arg Lys Val Leu His 
            100                 105                 110         


Leu Gly Tyr Ser Tyr Gln Glu Leu Gln Asp Met Thr Gly Glu Gln Ser 
        115                 120                 125             


Ala Gln Met Ala Val Tyr Phe Ile Lys Glu Ala Ala Lys Gln Ala Ala 
    130                 135                 140                 


Pro Gly Ser Glu Leu Ser Ala Glu Leu Ile Met Leu Asp Lys Phe Gly 
145                 150                 155                 160 


Asp Arg Arg Tyr Leu Gly Glu Leu Glu Ser Arg Arg Ile Ala Gln Ile 
                165                 170                 175     


Glu Asn Ile Tyr His Ser Ser Lys Gln Thr 
            180                 185     


<210>  17
<211>  561
<212>  PRT
<213>  Photorhabdus temperate

<400>  17

Met Glu Tyr Glu Tyr Asp Lys Thr Asp Asp Arg Lys Arg Lys His Ser 
1               5                   10                  15      


Thr Gln Trp Ala Asp Tyr Glu Glu Lys Ser Phe Val Pro Thr Leu Asp 
            20                  25                  30          


Leu Ser Gln Ser Arg Gln His Asn Pro Ser His Asp Ala Leu Asn Arg 
        35                  40                  45              


Ala Asp Asn His Glu Thr Ser Pro Leu Leu His Asn Leu Ile Thr Ser 
    50                  55                  60                  


Asp Asn Leu Arg Lys Glu Ala Ala Val Phe Ala Lys Arg Ile Gly Ser 
65                  70                  75                  80  


Ser Tyr Gln Gly Ile Leu Asp Gly Leu His Arg Ile His Thr Leu Ser 
                85                  90                  95      


Gly Asn Glu Gln Leu Thr Ala Gly Phe Glu Leu His Gln Arg Ile Thr 
            100                 105                 110         


Arg Tyr Leu Lys Thr His Pro Asp Ser Lys Arg Asn Thr Ser Leu Arg 
        115                 120                 125             


Arg Met Gln Thr Gln Leu Glu Asp Leu Met Phe Thr Gly Thr Leu Gln 
    130                 135                 140                 


Met Val Arg Ser Pro Leu Leu Glu Met Ala Glu Thr Arg Pro Asp Met 
145                 150                 155                 160 


Ala Ser Arg Ile Tyr Gln Ile Ala Cys Asn Glu Thr Arg Gly Asn Thr 
                165                 170                 175     


Pro Gly Leu Thr Asp Leu Met Val Arg Trp Val Lys Glu Asp Pro Tyr 
            180                 185                 190         


Leu Ala Thr Lys Thr Gly Tyr Gln Gly Glu Ile Pro Asn Asp Leu Pro 
        195                 200                 205             


Phe Asp Pro Lys Phe His Val Glu Leu Gly Ala Gln Phe Asp Asp Phe 
    210                 215                 220                 


Lys Lys Trp Leu Asn Ile Ala Gln Ser Gln Gly Leu Leu Thr His Ala 
225                 230                 235                 240 


Arg Leu Asp Glu Pro Ser Lys Arg Val His Leu Gly Tyr Ser Tyr Asn 
                245                 250                 255     


Glu Leu Leu Asp Met Thr Gly Val Glu Ser Val Gln Met Ala Val Tyr 
            260                 265                 270         


Phe Leu Lys Glu Ala Ala Lys Gln Ala Asp Pro Gly Phe Ala Gly Ser 
        275                 280                 285             


Gln Glu Ala Ile Leu Leu Asn Arg Phe Ala Asn Pro Ala Tyr Leu Ala 
    290                 295                 300                 


Gln Leu Glu Gln Gly Arg Leu Ser Gln Ile Glu Ala Ile Tyr His Ser 
305                 310                 315                 320 


Ser His Asn Thr Asp Val Ala Ala Trp Asp Lys Gln Phe Asp Ala Asp 
                325                 330                 335     


Ala Leu Val Gln Leu Asn His Gln Leu Asn Gly Ser Thr Asp Leu Asp 
            340                 345                 350         


Ser Gln Leu Ser Leu Leu Leu Lys Asn Arg Gln Gly Leu Leu Ile Gly 
        355                 360                 365             


Glu Ser His Gly Ser Asp Leu Asn Gly Leu Arg Phe Val Asn Glu Gln 
    370                 375                 380                 


Met Asn Ala Leu Lys Ala His Gly Val Ser Val Ile Gly Leu Glu His 
385                 390                 395                 400 


Leu Arg Ser Asp Leu Ala Gln Pro Leu Ile Asp Asn Phe Leu Ala Ser 
                405                 410                 415     


Gly Asp Met Ser Ala Glu Leu Ala Ala Met Ile Lys Thr Lys His Leu 
            420                 425                 430         


Asp Pro Ala Leu Phe Glu Gln Ala Arg Ile Lys Ser Met Lys Ile Ile 
        435                 440                 445             


Ala Leu Asp Asp Asn Ser Thr Thr Arg Pro Val Val Ala Gly Thr Gln 
    450                 455                 460                 


His Gly Leu Met Tyr Arg Ala Gly Ala Ala Asn Asn Val Ala Val Glu 
465                 470                 475                 480 


Arg Leu Gln Gln Leu Pro Val Gly Glu Lys Phe Val Ala Ile Tyr Gly 
                485                 490                 495     


Asn Ala His Leu Gln Ser His Glu Gly Ile Asp His Phe Ile Pro Gly 
            500                 505                 510         


Met Thr His Arg Leu Gly Leu Pro Ala Leu Lys Val Asp Ala Asn Asn 
        515                 520                 525             


His Phe Val Ala Gln Ala Asp Asp Thr Ser Gln Arg Lys Arg Tyr Asp 
    530                 535                 540                 


Asp Val Ala Asn Val Pro Arg Ile Gln Leu Ile Pro Gln Ala Lys Leu 
545                 550                 555                 560 


Leu 
    


<210>  18
<211>  220
<212>  PRT
<213>  Photorhabdus temperate

<400>  18

Phe Glu Leu His Gln Arg Ile Thr Arg Tyr Leu Lys Thr His Pro Asp 
1               5                   10                  15      


Ser Lys Arg Asn Thr Ser Leu Arg Arg Met Gln Thr Gln Leu Glu Asp 
            20                  25                  30          


Leu Met Phe Thr Gly Thr Leu Gln Met Val Arg Ser Pro Leu Leu Glu 
        35                  40                  45              


Met Ala Glu Thr Arg Pro Asp Met Ala Ser Arg Ile Tyr Gln Ile Ala 
    50                  55                  60                  


Cys Asn Glu Thr Arg Gly Asn Thr Pro Gly Leu Thr Asp Leu Met Val 
65                  70                  75                  80  


Arg Trp Val Lys Glu Asp Pro Tyr Leu Ala Thr Lys Thr Gly Tyr Gln 
                85                  90                  95      


Gly Glu Ile Pro Asn Asp Leu Pro Phe Asp Pro Lys Phe His Val Glu 
            100                 105                 110         


Leu Gly Ala Gln Phe Asp Asp Phe Lys Lys Trp Leu Asn Ile Ala Gln 
        115                 120                 125             


Ser Gln Gly Leu Leu Thr His Ala Arg Leu Asp Glu Pro Ser Lys Arg 
    130                 135                 140                 


Val His Leu Gly Tyr Ser Tyr Asn Glu Leu Leu Asp Met Thr Gly Val 
145                 150                 155                 160 


Glu Ser Val Gln Met Ala Val Tyr Phe Leu Lys Glu Ala Ala Lys Gln 
                165                 170                 175     


Ala Asp Pro Gly Phe Ala Gly Ser Gln Glu Ala Ile Leu Leu Asn Arg 
            180                 185                 190         


Phe Ala Asn Pro Ala Tyr Leu Ala Gln Leu Glu Gln Gly Arg Leu Ser 
        195                 200                 205             


Gln Ile Glu Ala Ile Tyr His Ser Ser His Asn Thr 
    210                 215                 220 


<210>  19
<211>  531
<212>  PRT
<213>  Xenorhabdus nematophila

<400>  19

Ala Leu Ser Gly Lys Asn Lys Thr Leu Glu Thr Val Ile Ala Glu Asn 
1               5                   10                  15      


Asp Gly Thr Pro Ser Leu Asn Glu Leu Ile Thr Lys Asp Gly Leu Arg 
            20                  25                  30          


Lys Lys Ala Ser Val Phe Ala Lys Pro Ile Gly Pro Ala Tyr Gln Ala 
        35                  40                  45              


Ile Leu Asp Lys Leu Asp His Ile His Asn Leu Thr Gly Asn Glu Gln 
    50                  55                  60                  


Leu Ser Ala Gly Phe Glu Leu Tyr Gln Arg Ile Thr Arg Tyr Leu Asn 
65                  70                  75                  80  


Glu His Pro Asp Ser Lys Arg Asn Thr Ala Leu Ser Gly Val Gln Thr 
                85                  90                  95      


Gln Leu Gly Asp Ile Met Phe Arg Gly Ala Leu Gln Glu Val Arg Ser 
            100                 105                 110         


Pro Leu Leu Glu Ile Ala Gln Thr Arg Pro Glu Met Ala Ser Arg Ile 
        115                 120                 125             


Tyr Gln Ile Ala Arg Asn Glu Ala Arg Gly Asp Thr Pro Gly Leu Thr 
    130                 135                 140                 


Asp Leu Met Val Arg Trp Val Lys Glu Asp Pro Tyr Leu Ala Ala Lys 
145                 150                 155                 160 


Leu Gly Tyr Gln Gly Glu Ile Pro Ala Asp Leu Ala Phe Asn Pro Lys 
                165                 170                 175     


Phe His Val Asp Leu Gly Asp Gln Phe Asp Asp Phe Lys Gln Cys Leu 
            180                 185                 190         


Ser Lys Ala Gln Asp Lys Gly Leu Leu Ile Asn Ala Arg Ile Asp Glu 
        195                 200                 205             


Gln Asn Lys Arg Val His Leu Gly Tyr Ser Tyr Asn Glu Leu Leu Asp 
    210                 215                 220                 


Met Thr Gly Ser Glu Asp Val Lys Met Ala Val Tyr Phe Leu Lys Glu 
225                 230                 235                 240 


Val Ala Lys Gln Ala Asp Pro Asn Phe Ala Gly Ser His Glu Ala Ile 
                245                 250                 255     


Leu Leu Asn Arg Phe Ala Asn Pro Ala Tyr Leu Val Gln Leu Glu Gln 
            260                 265                 270         


Gly Arg Leu Ala Gln Ile Glu Ala Ile Tyr His Ser Ser His Gln Thr 
        275                 280                 285             


Asp Ile Ala Ala Trp Asp Lys Gln Tyr Ser Ser Asp Ala Leu Thr Gln 
    290                 295                 300                 


Leu Asn Arg Gln Leu Ser Asp Gly Thr Asp Leu Asn Ser Gln Leu Ser 
305                 310                 315                 320 


Leu Leu Leu Lys Asp Arg Gln Gly Leu Leu Ile Gly Glu Ser His Gly 
                325                 330                 335     


Ser Asp Leu Asn Gly Leu Arg Phe Val Asn Glu Gln Met Asp Ala Leu 
            340                 345                 350         


Lys Val His Gly Val Thr Val Ile Gly Leu Glu His Leu Arg Ser Asp 
        355                 360                 365             


Leu Ala Gln Pro Leu Ile Asp Lys Phe Leu Ala Gly Gly Asp Met Pro 
    370                 375                 380                 


Ala Glu Leu Thr Ala Met Ile Glu Thr Lys His Leu Pro Val Asp Leu 
385                 390                 395                 400 


Phe Glu Gln Ala Lys Ser Lys Gly Ile Lys Ile Ile Ala Leu Asp Asp 
                405                 410                 415     


Asn Ser Thr Thr Arg Pro Ala Ile Glu Gly Ser Gln His Gly Leu Met 
            420                 425                 430         


Tyr Arg Ala Gly Ala Ala Asn Asn Val Ala Val Lys Arg Leu Gly Leu 
        435                 440                 445             


Leu Ala Glu Gly Glu Lys Phe Val Ala Ile Tyr Gly Asp Ala His Leu 
    450                 455                 460                 


Gln Ser His Glu Gly Ile Asp His Phe Val Pro Gly Met Thr His Arg 
465                 470                 475                 480 


Leu Gly Leu Pro Ala Leu Lys Val Asp Ala Asn Asn Arg Phe Thr Ala 
                485                 490                 495     


Gln Ala Asp Asp Ile Ser Leu Arg Lys His Tyr Asp Asp Val Pro Gln 
            500                 505                 510         


Leu Glu Lys Asn Leu Tyr Lys Pro Asn Arg Val Val Gly Gly Asp Leu 
        515                 520                 525             


Glu Val Leu 
    530     


<210>  20
<211>  186
<212>  PRT
<213>  Xenorhabdus nematophila

<400>  20

Phe Arg Gly Ala Leu Gln Glu Val Arg Ser Pro Leu Leu Glu Ile Ala 
1               5                   10                  15      


Gln Thr Arg Pro Glu Met Ala Ser Arg Ile Tyr Gln Ile Ala Arg Asn 
            20                  25                  30          


Glu Ala Arg Gly Asp Thr Pro Gly Leu Thr Asp Leu Met Val Arg Trp 
        35                  40                  45              


Val Lys Glu Asp Pro Tyr Leu Ala Ala Lys Leu Gly Tyr Gln Gly Glu 
    50                  55                  60                  


Ile Pro Ala Asp Leu Ala Phe Asn Pro Lys Phe His Val Asp Leu Gly 
65                  70                  75                  80  


Asp Gln Phe Asp Asp Phe Lys Gln Cys Leu Ser Lys Ala Gln Asp Lys 
                85                  90                  95      


Gly Leu Leu Ile Asn Ala Arg Ile Asp Glu Gln Asn Lys Arg Val His 
            100                 105                 110         


Leu Gly Tyr Ser Tyr Asn Glu Leu Leu Asp Met Thr Gly Ser Glu Asp 
        115                 120                 125             


Val Lys Met Ala Val Tyr Phe Leu Lys Glu Val Ala Lys Gln Ala Asp 
    130                 135                 140                 


Pro Asn Phe Ala Gly Ser His Glu Ala Ile Leu Leu Asn Arg Phe Ala 
145                 150                 155                 160 


Asn Pro Ala Tyr Leu Val Gln Leu Glu Gln Gly Arg Leu Ala Gln Ile 
                165                 170                 175     


Glu Ala Ile Tyr His Ser Ser His Gln Thr 
            180                 185     


<210>  21
<211>  568
<212>  PRT
<213>  Photorhabdus luminescens

<400>  21

Met Thr Gly Val Ser Glu Cys Ser Gln Gln Arg Ser Asn Leu Lys Asp 
1               5                   10                  15      


Asp Gly Tyr Ile Ser Ser Arg Lys Leu Thr Gly Asp Asn Met Val Tyr 
            20                  25                  30          


Glu Tyr Asp Lys Thr Ile Glu Arg Arg Arg Asn Pro Ser Ile Gln Leu 
        35                  40                  45              


Asn Asn Asn Glu Lys Ser Ser Glu Gln Ala Leu Glu Leu Ser Gln Asn 
    50                  55                  60                  


Asn Pro Leu Leu His Asp Leu Ile Thr Ser Asn Asn Leu Arg Lys Glu 
65                  70                  75                  80  


Ala Ala Val Phe Ala Lys Arg Ile Gly Pro Ser Tyr Gln Glu Ile Leu 
                85                  90                  95      


Asp Glu Leu Glu His Leu His His Leu Ser Gly Asn Glu Gln Leu Ala 
            100                 105                 110         


Ala Gly Phe Glu Leu His Arg Arg Ile Thr His Tyr Leu Glu Glu His 
        115                 120                 125             


Pro Asp Ser Lys Arg Asn Thr Ala Leu Arg Arg Thr Gln Thr Gln Phe 
    130                 135                 140                 


Gly Asp Leu Met Phe Thr Gly Thr Leu Gln Lys Ile Arg His Ser Leu 
145                 150                 155                 160 


Leu Glu Met Ala Glu Thr Arg Pro Glu Met Ala Ser His Ile Tyr Gln 
                165                 170                 175     


Ile Ala Arg Glu Glu Val Lys Gly Asn Thr Pro Gly Leu Thr Asp Leu 
            180                 185                 190         


Met Val Arg Trp Val Lys Glu Asp Pro Tyr Leu Ala Ala Lys Thr Gly 
        195                 200                 205             


Tyr Gln Gly Lys Ile Pro Asn Asp Leu Pro Phe Glu Pro Lys Phe His 
    210                 215                 220                 


Val Glu Leu Gly Ala Gln Phe Asp Asp Phe Lys Lys Trp Leu Asp Thr 
225                 230                 235                 240 


Ala Gln Ser Lys Glu Leu Leu Thr His Thr Arg Leu Asp Glu Gln Asn 
                245                 250                 255     


Lys Gln Val His Leu Gly Tyr Ser Tyr Asn Glu Leu Leu Asp Met Thr 
            260                 265                 270         


Gly Val Glu Ser Val Gln Met Ala Val Tyr Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Lys Gln Ala Glu Pro Gly Ser Thr Lys Ser Gln Glu Asp Ile Leu Leu 
    290                 295                 300                 


His Arg Phe Ala Asn Pro Thr Tyr Leu Ala Gln Leu Glu His Ser Arg 
305                 310                 315                 320 


Leu Ala Gln Ile Glu Ala Ile Tyr His Ser Ser His Asp Thr Asp Val 
                325                 330                 335     


Thr Ala Trp Asp Gln Gln Phe Ala Ser Asp Ala Leu Thr Gln Phe Asn 
            340                 345                 350         


His Gln Leu Asn Asn Thr Val Asp Leu Asn Ser Gln Leu Ser Leu Leu 
        355                 360                 365             


Leu Lys Asp Arg Gln Gly Leu Leu Ile Gly Glu Ser His Gly Ser Asp 
    370                 375                 380                 


Leu Asn Gly Leu Arg Phe Val Glu Glu Gln Met Glu Val Leu Lys Ala 
385                 390                 395                 400 


His Gly Val Thr Val Ile Gly Leu Glu His Leu Arg Ser Asp Leu Ala 
                405                 410                 415     


Gln Pro Leu Ile Asp Lys Phe Leu Ala Ser Gly Asn Glu Pro Met Pro 
            420                 425                 430         


Ala Glu Leu Ala Ala Leu Leu Lys Thr Lys His Leu Ser Ala Asn Leu 
        435                 440                 445             


Phe Glu Gln Ala Arg Ser Lys Gln Met Lys Ile Ile Ala Leu Asp Asn 
    450                 455                 460                 


Asn Ser Thr Thr Arg Pro Thr Val Glu Gly Thr Gln His Gly Leu Met 
465                 470                 475                 480 


Tyr Arg Ala Gly Ala Ala Asn Asn Val Ala Val Glu Arg Leu Arg Gln 
                485                 490                 495     


Leu Pro Ala Gly Glu Lys Phe Val Ala Ile Tyr Gly Asn Ala His Leu 
            500                 505                 510         


Gln Ser His Glu Gly Ile Asp His Phe Leu Pro Gly Ile Thr His Arg 
        515                 520                 525             


Leu Gly Leu Pro Ala Leu Lys Val Asp Glu Asn Asn Arg Phe Thr Ala 
    530                 535                 540                 


Gln Val Asp Asn Ile Asn Gln Arg Lys Arg Tyr Asp Asp Val Val Glu 
545                 550                 555                 560 


Leu Pro Arg Ile Gln Leu Thr Ser 
                565             


<210>  22
<211>  220
<212>  PRT
<213>  Photorhabdus luminescens

<400>  22

Phe Glu Leu His Arg Arg Ile Thr His Tyr Leu Glu Glu His Pro Asp 
1               5                   10                  15      


Ser Lys Arg Asn Thr Ala Leu Arg Arg Thr Gln Thr Gln Phe Gly Asp 
            20                  25                  30          


Leu Met Phe Thr Gly Thr Leu Gln Lys Ile Arg His Ser Leu Leu Glu 
        35                  40                  45              


Met Ala Glu Thr Arg Pro Glu Met Ala Ser His Ile Tyr Gln Ile Ala 
    50                  55                  60                  


Arg Glu Glu Val Lys Gly Asn Thr Pro Gly Leu Thr Asp Leu Met Val 
65                  70                  75                  80  


Arg Trp Val Lys Glu Asp Pro Tyr Leu Ala Ala Lys Thr Gly Tyr Gln 
                85                  90                  95      


Gly Lys Ile Pro Asn Asp Leu Pro Phe Glu Pro Lys Phe His Val Glu 
            100                 105                 110         


Leu Gly Ala Gln Phe Asp Asp Phe Lys Lys Trp Leu Asp Thr Ala Gln 
        115                 120                 125             


Ser Lys Glu Leu Leu Thr His Thr Arg Leu Asp Glu Gln Asn Lys Gln 
    130                 135                 140                 


Val His Leu Gly Tyr Ser Tyr Asn Glu Leu Leu Asp Met Thr Gly Val 
145                 150                 155                 160 


Glu Ser Val Gln Met Ala Val Tyr Phe Leu Lys Glu Ala Ala Lys Gln 
                165                 170                 175     


Ala Glu Pro Gly Ser Thr Lys Ser Gln Glu Asp Ile Leu Leu His Arg 
            180                 185                 190         


Phe Ala Asn Pro Thr Tyr Leu Ala Gln Leu Glu His Ser Arg Leu Ala 
        195                 200                 205             


Gln Ile Glu Ala Ile Tyr His Ser Ser His Asp Thr 
    210                 215                 220 


<210>  23
<211>  542
<212>  PRT
<213>  Photorhabdus asymbiotica

<400>  23

Met Val Phe Glu His Asp Lys Thr Val Glu Arg Lys Arg Lys Pro Ser 
1               5                   10                  15      


Ile Gln Leu Gly Asn Asp Lys Glu Lys Ser Ser Glu Gln Ala Leu Glu 
            20                  25                  30          


Leu Pro Gln Ser Lys Gln Asn Asn Pro Leu Leu His Asp Leu Ile Thr 
        35                  40                  45              


Ser Asn Asn Leu Arg Lys Glu Ala Ala Val Phe Ala Lys Gln Ile Gly 
    50                  55                  60                  


Pro Ser Tyr Gln Gly Ile Leu Asp Gly Leu Glu His Leu His Asn Leu 
65                  70                  75                  80  


Ser Gly Asn Glu Gln Leu Thr Ala Gly Phe Glu Leu His Arg Arg Ile 
                85                  90                  95      


Thr Arg Tyr Leu Glu Glu His Pro Asp Ser Lys Arg Asn Ala Ala Leu 
            100                 105                 110         


Arg Arg Thr Gln Thr Gln Leu Gly Asp Leu Met Phe Thr Gly Thr Leu 
        115                 120                 125             


Gln Glu Val Arg His Pro Leu Leu Glu Met Ala Glu Thr Arg Pro Ala 
    130                 135                 140                 


Met Ala Ser Gln Ile Tyr Gln Ile Ala Arg Asp Glu Ala Lys Gly Asn 
145                 150                 155                 160 


Thr Pro Gly Leu Thr Asp Leu Met Val Arg Trp Val Lys Glu Asp Pro 
                165                 170                 175     


Tyr Leu Ala Ala Lys Ser Gly Tyr Gln Gly Lys Ile Pro Asn Asp Leu 
            180                 185                 190         


Pro Phe Glu Pro Lys Phe His Val Glu Leu Gly Asp Gln Phe Gly Glu 
        195                 200                 205             


Phe Lys Thr Trp Leu Asp Thr Ala Gln Asn Gln Gly Leu Leu Thr His 
    210                 215                 220                 


Thr Arg Leu Asp Glu Gln Asn Lys Gln Val His Leu Gly Tyr Ser Tyr 
225                 230                 235                 240 


Asn Glu Leu Leu Asp Met Thr Gly Gly Val Glu Ser Val Lys Met Ala 
                245                 250                 255     


Val Tyr Phe Leu Lys Glu Ala Ala Lys Gln Ala Glu Pro Gly Ser Ala 
            260                 265                 270         


Lys Ser Gln Glu Ala Ile Leu Leu Asn Arg Phe Ala Asn Pro Ala Tyr 
        275                 280                 285             


Leu Thr Gln Leu Glu Gln Gly Arg Leu Ala Gln Met Glu Ala Ile Tyr 
    290                 295                 300                 


His Ser Ser His Asn Thr Asp Val Ala Ala Trp Asp Gln Gln Phe Ser 
305                 310                 315                 320 


Pro Asp Ala Leu Thr Gln Phe Asn His Gln Leu Asp Asn Ser Val Asp 
                325                 330                 335     


Leu Asn Ser Gln Leu Ser Phe Leu Leu Lys Asp Arg Gln Gly Leu Leu 
            340                 345                 350         


Ile Gly Glu Ser His Gly Ser Asp Leu Asn Gly Leu Arg Phe Val Glu 
        355                 360                 365             


Glu Gln Met Asp Ala Leu Lys Ala His Gly Val Thr Val Ile Gly Leu 
    370                 375                 380                 


Glu His Leu Arg Ser Asp Leu Ala Gln Pro Leu Ile Asp Lys Phe Leu 
385                 390                 395                 400 


Thr Ser Glu Asn Glu Pro Met Pro Ala Glu Leu Ala Ala Met Leu Lys 
                405                 410                 415     


Thr Lys His Leu Ser Val Asn Leu Phe Glu Gln Ala Arg Ser Lys Gln 
            420                 425                 430         


Met Lys Ile Ile Ala Leu Asp Asn Asn Ser Thr Thr Arg Pro Ala Glu 
        435                 440                 445             


Gly Glu His Ser Leu Met Tyr Arg Ala Gly Ala Ala Asn Asn Val Ala 
    450                 455                 460                 


Val Glu Arg Leu Gln Gln Leu Pro Ala Glu Glu Lys Phe Val Ala Ile 
465                 470                 475                 480 


Tyr Gly Asn Ala His Leu Gln Ser His Glu Gly Ile Asp His Phe Leu 
                485                 490                 495     


Pro Gly Ile Thr His Arg Leu Gly Leu Pro Ala Leu Lys Val Asp Glu 
            500                 505                 510         


Asn Asn Arg Phe Thr Ala Gln Ala Asp Asn Ile Asn Gln Arg Lys Cys 
        515                 520                 525             


Tyr Asp Asp Val Val Glu Val Ser Arg Ile Gln Leu Thr Ser 
    530                 535                 540         


<210>  24
<211>  221
<212>  PRT
<213>  Photorhabdus asymbiotica

<400>  24

Phe Glu Leu His Arg Arg Ile Thr Arg Tyr Leu Glu Glu His Pro Asp 
1               5                   10                  15      


Ser Lys Arg Asn Ala Ala Leu Arg Arg Thr Gln Thr Gln Leu Gly Asp 
            20                  25                  30          


Leu Met Phe Thr Gly Thr Leu Gln Glu Val Arg His Pro Leu Leu Glu 
        35                  40                  45              


Met Ala Glu Thr Arg Pro Ala Met Ala Ser Gln Ile Tyr Gln Ile Ala 
    50                  55                  60                  


Arg Asp Glu Ala Lys Gly Asn Thr Pro Gly Leu Thr Asp Leu Met Val 
65                  70                  75                  80  


Arg Trp Val Lys Glu Asp Pro Tyr Leu Ala Ala Lys Ser Gly Tyr Gln 
                85                  90                  95      


Gly Lys Ile Pro Asn Asp Leu Pro Phe Glu Pro Lys Phe His Val Glu 
            100                 105                 110         


Leu Gly Asp Gln Phe Gly Glu Phe Lys Thr Trp Leu Asp Thr Ala Gln 
        115                 120                 125             


Asn Gln Gly Leu Leu Thr His Thr Arg Leu Asp Glu Gln Asn Lys Gln 
    130                 135                 140                 


Val His Leu Gly Tyr Ser Tyr Asn Glu Leu Leu Asp Met Thr Gly Gly 
145                 150                 155                 160 


Val Glu Ser Val Lys Met Ala Val Tyr Phe Leu Lys Glu Ala Ala Lys 
                165                 170                 175     


Gln Ala Glu Pro Gly Ser Ala Lys Ser Gln Glu Ala Ile Leu Leu Asn 
            180                 185                 190         


Arg Phe Ala Asn Pro Ala Tyr Leu Thr Gln Leu Glu Gln Gly Arg Leu 
        195                 200                 205             


Ala Gln Met Glu Ala Ile Tyr His Ser Ser His Asn Thr 
    210                 215                 220     


<210>  25
<211>  504
<212>  PRT
<213>  Yersinia kristensenii

<400>  25

Ile Glu Ser Asn Val Ile Ile Ser Lys Asp Glu Leu Lys Lys Gln Ala 
1               5                   10                  15      


Ser Val Met Gly Lys Pro Ile Gly Tyr Ser Tyr Lys Lys Ile Leu Asn 
            20                  25                  30          


Ile Ile Asp Leu Ile Asn Ser Thr Ser Asn Ser Glu Arg Ile Lys Asn 
        35                  40                  45              


Ile Phe Ile Leu Lys Ser Glu Ile Glu Arg Tyr Ile Asn Glu His Pro 
    50                  55                  60                  


Ser Ser Gly Arg Asn Lys Ala Phe Leu Thr Leu Gly Glu Lys Ile Asp 
65                  70                  75                  80  


Lys Ser Leu Phe Asn Ser Lys Met Gln Pro Ala Lys Asn Ala Ile Leu 
                85                  90                  95      


Arg Leu Ser Lys Thr Gln Pro Glu Met Ala Ala Arg Leu Tyr Glu Val 
            100                 105                 110         


Ala Ala Arg Glu Ser Gln Gly Ser His Val Gly Leu Thr Asn Met Met 
        115                 120                 125             


His Val Trp Ile Ser Glu Asp Gly Tyr Leu Thr Leu Leu Lys Gly Phe 
    130                 135                 140                 


Glu Gly Lys Ile Pro Asp Arg Asn Leu Leu Asn Phe Asp Pro Thr Tyr 
145                 150                 155                 160 


His Ile Ala Thr Gly Asp Gln Phe Asp Glu Cys Lys Thr Lys Leu Leu 
                165                 170                 175     


Gln Ala Gln Ser Asn Gly Glu Leu Arg Gln Val Tyr Ile Asn Glu Ser 
            180                 185                 190         


Thr Arg Ser Phe Thr Ile Gly Tyr Thr Tyr Glu Glu Met Ala Ser Phe 
        195                 200                 205             


Arg Ala Arg Gly Ser Glu Asn Ser Gln Phe Phe Ser Tyr Ile Leu Asn 
    210                 215                 220                 


Glu Val Ala Gly Arg Asn Asn Ser Thr Asp Arg Ser Lys Glu Leu Asn 
225                 230                 235                 240 


Trp Leu Asp Asn Cys Ala Asp Lys Lys Phe Leu Lys Gln Leu Gln Leu 
                245                 250                 255     


Ser Arg Leu Asp Gln Ile Glu Ser Ile Tyr Gln Arg Asn Asn Lys Ile 
            260                 265                 270         


Asp Phe Ala Ser Trp Asp Ser Lys Tyr Ser Gly Ile Ser Arg Asp Arg 
        275                 280                 285             


Ile Asn Arg Glu Leu Asn Gln Tyr Gly Asp Val Asp Gly Gln Leu Ser 
    290                 295                 300                 


Val Leu Leu Arg Gly Asn Gln Gly Leu Leu Ile Gly Glu Thr His Gly 
305                 310                 315                 320 


Ser Gln Glu Glu Gly Arg Arg Phe Ile Ile Glu Gln Ile Ser Glu Leu 
                325                 330                 335     


Lys Arg His Gly Val Thr Thr Ile Gly Leu Glu His Leu Arg Arg Asp 
            340                 345                 350         


His Ile Gln Pro Leu Ile Asp Asp Tyr Tyr Arg Thr Gly Val Ile Ser 
        355                 360                 365             


Pro Asp Leu Asn Thr Phe Leu Thr Ala Lys Gly Val Lys Asn Ile Val 
    370                 375                 380                 


Thr Thr Ala Phe Glu Asn Lys Val Lys Ile Ile Phe Leu Asp Asp Asn 
385                 390                 395                 400 


Ser Thr Ser Lys Gly Ser Gly Asn His Ser Leu Met Tyr Arg Ala Gly 
                405                 410                 415     


Ser Ala Asn Asn Ile Ala Val Asp Ile Leu Lys Gln Ile Pro Ala Asn 
            420                 425                 430         


Glu Lys Phe Val Val Ile Tyr Gly Glu Ala His Leu Lys Ser His Ile 
        435                 440                 445             


Gly Ile Glu Ser Pro Val Ser Gly Ile Ser His Gln Met Lys Leu Pro 
    450                 455                 460                 


Ile Leu Gln Val Asp Ala Asn Asn Arg Leu Thr Val Ser Ala Asp Asp 
465                 470                 475                 480 


Pro Thr Gln Arg Thr Ile Tyr Pro Arg Asn Asn Thr Thr Gly Ser Pro 
                485                 490                 495     


Arg Ile Ile Phe Pro Ala Thr Leu 
            500                 


<210>  26
<211>  189
<212>  PRT
<213>  Yersinia kristensenii

<400>  26

Phe Asn Ser Lys Met Gln Pro Ala Lys Asn Ala Ile Leu Arg Leu Ser 
1               5                   10                  15      


Lys Thr Gln Pro Glu Met Ala Ala Arg Leu Tyr Glu Val Ala Ala Arg 
            20                  25                  30          


Glu Ser Gln Gly Ser His Val Gly Leu Thr Asn Met Met His Val Trp 
        35                  40                  45              


Ile Ser Glu Asp Gly Tyr Leu Thr Leu Leu Lys Gly Phe Glu Gly Lys 
    50                  55                  60                  


Ile Pro Asp Arg Asn Leu Leu Asn Phe Asp Pro Thr Tyr His Ile Ala 
65                  70                  75                  80  


Thr Gly Asp Gln Phe Asp Glu Cys Lys Thr Lys Leu Leu Gln Ala Gln 
                85                  90                  95      


Ser Asn Gly Glu Leu Arg Gln Val Tyr Ile Asn Glu Ser Thr Arg Ser 
            100                 105                 110         


Phe Thr Ile Gly Tyr Thr Tyr Glu Glu Met Ala Ser Phe Arg Ala Arg 
        115                 120                 125             


Gly Ser Glu Asn Ser Gln Phe Phe Ser Tyr Ile Leu Asn Glu Val Ala 
    130                 135                 140                 


Gly Arg Asn Asn Ser Thr Asp Arg Ser Lys Glu Leu Asn Trp Leu Asp 
145                 150                 155                 160 


Asn Cys Ala Asp Lys Lys Phe Leu Lys Gln Leu Gln Leu Ser Arg Leu 
                165                 170                 175     


Asp Gln Ile Glu Ser Ile Tyr Gln Arg Asn Asn Lys Ile 
            180                 185                 


<210>  27
<211>  503
<212>  PRT
<213>  Pasteurella multocida

<400>  27

Ile Gly Leu Glu Gly Val Trp Thr Pro Glu Val Leu Lys Ala Arg Ala 
1               5                   10                  15      


Ser Val Ile Gly Lys Pro Ile Gly Glu Ser Tyr Lys Arg Ile Leu Ala 
            20                  25                  30          


Lys Leu Gln Arg Ile His Asn Ser Asn Ile Leu Asp Glu Arg Gln Gly 
        35                  40                  45              


Leu Met His Glu Leu Met Glu Leu Ile Asp Leu Tyr Glu Glu Ser Gln 
    50                  55                  60                  


Pro Ser Ser Glu Arg Leu Asn Ala Phe Arg Glu Leu Arg Thr Gln Leu 
65                  70                  75                  80  


Glu Lys Ala Leu Tyr Leu Pro Glu Met Glu Ala Leu Lys Lys Gln Ile 
                85                  90                  95      


Leu Gln Ile Pro Asn Lys Gly Ser Gly Ala Ala Arg Phe Leu Leu Arg 
            100                 105                 110         


Thr Ala Met Asn Glu Met Ala Gly Lys Thr Ser Glu Ser Thr Ala Asp 
        115                 120                 125             


Leu Ile Arg Phe Ala Leu Gln Asp Thr Val Ile Ser Ala Pro Phe Arg 
    130                 135                 140                 


Gly Tyr Ala Gly Ala Ile Pro Glu Ala Ile Asp Phe Pro Val Lys Tyr 
145                 150                 155                 160 


Val Ile Glu Asp Ile Ser Val Phe Asp Lys Ile Gln Thr Asn Tyr Trp 
                165                 170                 175     


Glu Leu Pro Ala Tyr Glu Ser Trp Asn Glu Gly Ser Asn Ser Ala Leu 
            180                 185                 190         


Leu Pro Gly Leu Leu Arg Glu Ser Gln Ser Lys Gly Met Leu Ser Lys 
        195                 200                 205             


Cys Arg Ile Ile Glu Asn Ser Leu Tyr Ile Gly His Ser Tyr Glu Glu 
    210                 215                 220                 


Met Phe Tyr Ser Ile Ser Pro Tyr Ser Asn Gln Val Gly Gly Pro Tyr 
225                 230                 235                 240 


Glu Leu Tyr Pro Phe Thr Phe Phe Ser Met Leu Gln Glu Val Gln Gly 
                245                 250                 255     


Asp Leu Gly Phe Glu Gln Ala Phe Ala Thr Arg Asn Tyr Phe Asn Thr 
            260                 265                 270         


Leu Val Ser Asp Arg Leu Ser Leu Met Glu Asn Thr Met Leu Leu Thr 
        275                 280                 285             


Glu Ser Phe Asp Tyr Thr Pro Trp Asp Ala Ile Tyr Gly Asp Ile Asn 
    290                 295                 300                 


Tyr Asp Glu Gln Phe Ala Ala Met Ser Ile Asn Glu Arg Ile Glu Lys 
305                 310                 315                 320 


Cys Met Asn Thr Tyr Arg Gly Val Ala Phe Gln Asn Ser Ser Lys Ser 
                325                 330                 335     


Ile Asp Phe Phe Leu Asn Asn Leu Thr Thr Phe Ile Asp Asn Gly Leu 
            340                 345                 350         


Thr Glu Ile Ala Ile Ser Asp Leu Pro Tyr Asp Ile Val Gln Gln Glu 
        355                 360                 365             


Ile Ser Gln Phe Leu Gln Gly Ser Asn Glu Trp Lys Thr Leu Asp Ala 
    370                 375                 380                 


Met Leu Phe Asn Leu Asp Lys Gly Asp Ile Asn Gly Ala Phe Arg Lys 
385                 390                 395                 400 


Leu Leu Gln Ser Ala Lys Asp Asn Asn Ile Lys Phe Arg Ala Ile Gly 
                405                 410                 415     


His Ser Asp Asn Ser Val Pro Pro Phe Asn Asn Pro Tyr Lys Ser Leu 
            420                 425                 430         


Tyr Tyr Lys Gly Asn Ile Ile Ala Glu Ala Ile Glu Lys Leu Asp Arg 
        435                 440                 445             


Glu Gly Gln Lys Phe Val Val Phe Ala Asp Ser Ser Leu Leu Asn Ser 
    450                 455                 460                 


Thr Pro Gly Thr Gly Arg Pro Met Pro Gly Leu Val Gln Tyr Leu Lys 
465                 470                 475                 480 


Ile Pro Ala Thr Val Val Asp Ser Asp Gly Ala Trp Gln Phe Leu Pro 
                485                 490                 495     


Asp Val Ala Ser Ser Arg Val 
            500             


<210>  28
<211>  207
<212>  PRT
<213>  Pasteurella multocida

<400>  28

Tyr Leu Pro Glu Met Glu Ala Leu Lys Lys Gln Ile Leu Gln Ile Pro 
1               5                   10                  15      


Asn Lys Gly Ser Gly Ala Ala Arg Phe Leu Leu Arg Thr Ala Met Asn 
            20                  25                  30          


Glu Met Ala Gly Lys Thr Ser Glu Ser Thr Ala Asp Leu Ile Arg Phe 
        35                  40                  45              


Ala Leu Gln Asp Thr Val Ile Ser Ala Pro Phe Arg Gly Tyr Ala Gly 
    50                  55                  60                  


Ala Ile Pro Glu Ala Ile Asp Phe Pro Val Lys Tyr Val Ile Glu Asp 
65                  70                  75                  80  


Ile Ser Val Phe Asp Lys Ile Gln Thr Asn Tyr Trp Glu Leu Pro Ala 
                85                  90                  95      


Tyr Glu Ser Trp Asn Glu Gly Ser Asn Ser Ala Leu Leu Pro Gly Leu 
            100                 105                 110         


Leu Arg Glu Ser Gln Ser Lys Gly Met Leu Ser Lys Cys Arg Ile Ile 
        115                 120                 125             


Glu Asn Ser Leu Tyr Ile Gly His Ser Tyr Glu Glu Met Phe Tyr Ser 
    130                 135                 140                 


Ile Ser Pro Tyr Ser Asn Gln Val Gly Gly Pro Tyr Glu Leu Tyr Pro 
145                 150                 155                 160 


Phe Thr Phe Phe Ser Met Leu Gln Glu Val Gln Gly Asp Leu Gly Phe 
                165                 170                 175     


Glu Gln Ala Phe Ala Thr Arg Asn Tyr Phe Asn Thr Leu Val Ser Asp 
            180                 185                 190         


Arg Leu Ser Leu Met Glu Asn Thr Met Leu Leu Thr Glu Ser Phe 
        195                 200                 205         


<210>  29
<211>  9
<212>  PRT
<213>  Influenza virus

<400>  29

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  30
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplying rtxA1 gene of Vibrio vulnificus

<400>  30
aaggtaccgt ttatcggtaa gatgcaagtt gcc                                    33


<210>  31
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplying rtxA1 gene of Vibrio vulnificus

<400>  31
agaattctca caaactgccc ttgaacgtga tc                                     32


<210>  32
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplying rtxA1 gene of Vibrio vulnificus

<400>  32
aaggtaccgg gtgataaaac caaggtcgtg                                        30


<210>  33
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplying rtxA1 gene of Vibrio vulnificus

<400>  33
aaggtaccgg atattgacgc ttgggatcgt                                        30


<210>  34
<211>  169
<212>  DNA
<213>  Artificial

<220>
<223>  Coding sequence for mutant form of Vibrio vulnificus DUF5 
       polypeptide having D3721R/R3841D mutations

<400>  34
atctttatgg tcgcgattga agaagccaac ggtaaacacg taggtttgac ggacatgatg       60

gttcgttggg ccaatgaaga accatacttg gcaccgaagc atggttacaa aggcgaaacg      120

ccaagtgacc ttggttttga tgcgaagtac cacgtagatc taggtgagc                  169


<210>  35
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplifying coding sequence of Vibrio 
       vulnificus DUF5

<400>  35
tacttccaat ccaatgctca agagctgaaa gaaagagcaa aag                         43


<210>  36
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplifying coding sequence of Vibrio 
       vulnificus DUF5

<400>  36
tacttccaat ccaatgctca agagctgaaa gaaagagcaa aag                         43


<210>  37
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplifying coding sequence for DUF5 
       polypeptide of Vibrio vulnificus

<400>  37
tacttccaat ccaatgctca agagctgaaa gaaagagcaa aag                         43


<210>  38
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplifying coding sequence for DUF5 
       polypeptide of Vibrio vulnificus

<400>  38
ttatccactt ccaatgctac aaactgccct tgaacgtg                               38


<210>  39
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplifying coding sequence for DUF5 
       polypeptide of Aeromonas hydrophila

<400>  39
tacttccaat ccaatgctcc gggcaaaacg gtggtgacg                              39


<210>  40
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplifying coding sequence for DUF5 
       polypeptide of Aeromonas hydrophila

<400>  40
ttatccactt ccaatgctag acatcggcgt actcgacccg c                           41


<210>  41
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplifying coding sequence for DUF5 
       polypeptide of Photorabdus asymbiotica

<400>  41
tacttccaat ccaatgctcc attactccat gacctcatca cc                          42


<210>  42
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplifying coding sequence for DUF5 
       polypeptide of Photorabdus asymbiotica

<400>  42
ttatccactt ccaatgctac acatcatcat aacacttgcg                             40


<210>  43
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplifying coding sequence of human KRAS

<400>  43
tacttccaat ccaatgctat gactgaatat aaacttgtgg tagttggagc tgg              53


<210>  44
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplifying coding sequence of human KRAS

<400>  44
ttatccactt ccaatgctac ataattacac actttgtctt tgacttcttt ttcttc           56


<210>  45
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplifying coding sequence of human HRAS

<400>  45
tacttccaat ccaatgctat gacggaatat aagctggtgg tggtg                       45


<210>  46
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplifying coding sequence of human HRAS

<400>  46
ttatccactt ccaatgctag gagagcacac acttgcagct c                           41


<210>  47
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplifying coding sequence of human NRAS

<400>  47
tacttccaat ccaatgctat gactgagtac aaactggtgg tgg                         43


<210>  48
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplifying coding sequence of human NRAS

<400>  48
ttatccactt ccaatgctac atcaccacac atggcaatcc c                           41


<210>  49
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplifying human EGF

<400>  49
gcttcgaatt ctgcacccgg gtggtctggt tccgcgtgga                             40


<210>  50
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplifying human EGF

<400>  50
ctagatccgg tggatcccct cagtggtggt ggtggtggtg c                           41


<210>  51
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplifying mutant human KRAS having the G13D 
       mutation

<400>  51
tagttggagc tggtgacgta ggcaagagtg c                                      31


<210>  52
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplifying mutant human KRAS having the G13D 
       mutation

<400>  52
gcactcttgc ctacgtcacc agctccaact a                                      31


<210>  53
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplifying mutant human KRAS having the Q61R 
       mutation

<400>  53
gatattctcg acacagcagg tagagaggag tacagtgcaa tg                          42


<210>  54
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplifying mutant human KRAS having the Q61R 
       mutation

<400>  54
cattgcactg tactcctctc tacctgctgt gtcgagaata tc                          42


<210>  55
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for applying rtxA1 gene of Vibrio vulnificus

<400>  55
gagctagcat gggtgataaa accaaggtcg tggattta                               38


<210>  56
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplifying rtxA1 gene of Vibrio vulnificus

<400>  56
gccgtcgacc aaactgccct tgaacgtgat cttcggttt                              39


