                         SEQUENCE LISTING

<110>  OHIO STATE INNOVATION FOUNDATION
 
<120>  IMPROVED PEPTIDYL CALCINEURIN INHIBITORS

<130>  10336-110WO1

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Pro or a Pro analogue

<400>  1

Xaa Ile Xaa Ile Thr Xaa Xaa 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Pro or a Pro analogue

<400>  2

Xaa Ile Xaa Ile Thr Gly Xaa 
1               5           


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  tert-leucine

<400>  3

Gly Pro His Pro Xaa Ile Xaa Ile Thr Gly Pro His Glu Glu 
1               5                   10                  


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  dimethylthiazolidine-4-carboxylic acid

<400>  4

Gly Pro His Pro Xaa Ile Xaa Ile Thr Gly Xaa His Glu Glu 
1               5                   10                  


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  any amino acid

<400>  5

Pro Xaa Ile Xaa Ile Thr 
1               5       


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Gly Pro His Ala Val Ala Val Ala Ala Gly Pro His Glu Glu 
1               5                   10                  


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10          


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-naphthylalanine

<400>  8

Phe Xaa Arg Arg Arg Gln 
1               5       


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-naphthylalanine

<400>  9

Phe Xaa Arg Arg Arg Cys 
1               5       


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  selenocysteine

<400>  10

Phe Xaa Arg Arg Arg Xaa 
1               5       


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  L-naphthylalanine

<400>  11

Arg Arg Arg Xaa Phe Gln 
1               5       


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  L-naphthylalanine

<400>  12

Arg Arg Arg Arg Xaa Phe 
1               5       


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-naphthylalanine

<400>  13

Phe Xaa Arg Arg Arg Arg 
1               5       


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-naphthylalanine

<400>  14

Phe Xaa Arg Arg Arg Arg Gln 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-naphthylalanine

<400>  15

Phe Xaa Arg Arg Arg Arg Gln 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-naphthylalanine

<400>  16

Phe Xaa Arg Arg Arg Arg Gln 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-naphthylalanine

<400>  17

Xaa Xaa Arg Arg Arg Arg Gln 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  L-naphthylalanine

<400>  18

Arg Arg Phe Arg Xaa Arg Gln 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  L-naphthylalanine

<400>  19

Phe Arg Arg Arg Arg Xaa Gln 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  L-naphthylalanine

<400>  20

Arg Arg Phe Arg Xaa Arg Gln 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-naphthylalanine

<400>  21

Arg Arg Xaa Phe Arg Arg Gln 
1               5           


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Cys Arg Arg Arg Arg Phe Trp Gln 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-naphthylalanine

<400>  23

Phe Xaa Xaa Arg Arg Arg Arg Gln 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-naphthylalanine

<400>  24

Phe Phe Xaa Arg Arg Arg Arg Gln 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  L-naphthylalanine

<400>  25

Arg Phe Arg Phe Arg Xaa Arg Gln 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  selenocysteine

<400>  26

Xaa Arg Arg Arg Arg Phe Trp Gln 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27

Cys Arg Arg Arg Arg Phe Trp Gln 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-naphthylalanine

<400>  28

Phe Xaa Arg Arg Arg Arg Gln Lys 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-naphthylalanine

<400>  29

Phe Xaa Arg Arg Arg Arg Gln Cys 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-naphthylalanine

<400>  30

Xaa Xaa Arg Arg Arg Arg Arg Gln 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-naphthylalanine

<400>  31

Phe Xaa Arg Arg Arg Arg Arg Gln 
1               5               


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  L-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  L-norleucine

<400>  32

Arg Arg Arg Arg Xaa Phe Asp Xaa Cys 
1               5                   


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Pro or a Pro analogue

<400>  33

Pro Xaa Ile Xaa Ile Thr Xaa Xaa 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Pro or a Pro analogue

<400>  34

Xaa Ile Xaa Ile Thr Xaa Xaa His 
1               5               


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Pro or a Pro analogue

<400>  35

Pro Xaa Ile Xaa Ile Thr Xaa Xaa His 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Pro or a Pro analogue

<400>  36

Xaa Ile Xaa Ile Thr Xaa Xaa His Glu 
1               5                   


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Pro or a Pro analogue

<400>  37

Pro Xaa Ile Xaa Ile Thr Xaa Xaa His Glu 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Pro or a Pro analogue

<400>  38

Xaa Ile Xaa Ile Thr Xaa Xaa His Glu Glu 
1               5                   10  


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Pro or a Pro analogue

<400>  39

Pro Xaa Ile Xaa Ile Thr Xaa Xaa His Glu Glu 
1               5                   10      


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  dimethylthiazolidine-4-carboxylic acid

<400>  40

Pro Xaa Ile Xaa Ile Thr Xaa Xaa 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  dimethylthiazolidine-4-carboxylic acid

<400>  41

Xaa Ile Xaa Ile Thr Xaa Xaa His 
1               5               


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  dimethylthiazolidine-4-carboxylic acid

<400>  42

Pro Xaa Ile Xaa Ile Thr Xaa Xaa His 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  dimethylthiazolidine-4-carboxylic acid

<400>  43

Xaa Ile Xaa Ile Thr Xaa Xaa His Glu 
1               5                   


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  dimethylthiazolidine-4-carboxylic acid

<400>  44

Pro Xaa Ile Xaa Ile Thr Xaa Xaa His Glu 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  dimethylthiazolidine-4-carboxylic acid

<400>  45

Xaa Ile Xaa Ile Thr Xaa Xaa His Glu Glu 
1               5                   10  


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  tert-leucine, L-penicillamine, or an S-alkylated derivative of 
       L-penicillamine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  dimethylthiazolidine-4-carboxylic acid

<400>  46

Pro Xaa Ile Xaa Ile Thr Xaa Xaa His Glu Glu 
1               5                   10      


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Gly Pro His Pro Val Ile Val Ile Thr Gly Pro His Glu Glu 
1               5                   10                  


