                         SEQUENCE LISTING

<110>  INNATE PHARMA
 
<120>  CROSS REACTIVE SIGLEC ANTIBODIES

<130>  Sig7-9

<150>  US 62/048,292
<151>  2014-09-10

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Val 
1               5                   10                  15      


Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr 
    50                  55                  60                  


Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr 
65                  70                  75                  80  


Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His 
                85                  90                  95      


Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp 
            100                 105                 110         


Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly 
        115                 120                 125             


Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr 
    130                 135                 140                 


Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser 
145                 150                 155                 160 


Gly Cys Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln 
                165                 170                 175     


Gly Thr Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu 
            180                 185                 190         


His Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro 
        195                 200                 205             


Gln His His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala 
    210                 215                 220                 


Gly Val Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro 
225                 230                 235                 240 


Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr 
                245                 250                 255     


Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu 
            260                 265                 270         


Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp 
        275                 280                 285             


Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu 
    290                 295                 300                 


Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser 
                325                 330                 335     


Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu 
            340                 345                 350         


Leu Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser 
        355                 360                 365             


Phe Cys Val Ile Phe Ile Val Val Arg Ser Cys Arg Lys Lys Ser Ala 
    370                 375                 380                 


Arg Pro Ala Ala Asp Val Gly Asp Ile Gly Met Lys Asp Ala Asn Thr 
385                 390                 395                 400 


Ile Arg Gly Ser Ala Ser Gln Gly Asn Leu Thr Glu Ser Trp Ala Asp 
                405                 410                 415     


Asp Asn Pro Arg His His Gly Leu Ala Ala His Ser Ser Gly Glu Glu 
            420                 425                 430         


Arg Glu Ile Gln Tyr Ala Pro Leu Ser Phe His Lys Gly Glu Pro Gln 
        435                 440                 445             


Asp Leu Ser Gly Gln Glu Ala Thr Asn Asn Glu Tyr Ser Glu Ile Lys 
    450                 455                 460                 


Ile Pro Lys 
465         


<210>  2
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 
1               5                   10                  15      


Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 
    50                  55                  60                  


Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 
65                  70                  75                  80  


Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 
                85                  90                  95      


Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 
            100                 105                 110         


Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 
        115                 120                 125             


Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 
    130                 135                 140                 


Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 
145                 150                 155                 160 


Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 
                165                 170                 175     


Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 
            180                 185                 190         


Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 
        195                 200                 205             


Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 
    210                 215                 220                 


Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 
225                 230                 235                 240 


Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 
                245                 250                 255     


Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 
            260                 265                 270         


Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 
        275                 280                 285             


Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 
    290                 295                 300                 


Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 
                325                 330                 335     


Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Val Val Gly Gly 
            340                 345                 350         


Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys Val Ile Phe Val 
        355                 360                 365             


Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val 
    370                 375                 380                 


Gly Asp Thr Gly Ile Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser 
385                 390                 395                 400 


Gln Gly Pro Leu Thr Glu Pro Trp Ala Glu Asp Ser Pro Pro Asp Gln 
                405                 410                 415     


Pro Pro Pro Ala Ser Ala Arg Ser Ser Val Gly Glu Gly Glu Leu Gln 
            420                 425                 430         


Tyr Ala Ser Leu Ser Phe Gln Met Val Lys Pro Trp Asp Ser Arg Gly 
        435                 440                 445             


Gln Glu Ala Thr Asp Thr Glu Tyr Ser Glu Ile Lys Ile His Arg 
    450                 455                 460             


<210>  3
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  3

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Tyr Tyr Arg Tyr Asp Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  4
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Thr Val Gly Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Asn Arg Asn Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Asn Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  5

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  6
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  6

Gly Tyr Ser Phe Thr Ser Tyr 
1               5           


<210>  7
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  7

Ser Tyr Trp Met His 
1               5   


<210>  8
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  8

Ile Tyr Pro Gly Asn Ser Asp Thr 
1               5               


<210>  9
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  9

Pro Gly Asn Ser 
1               


<210>  10
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  10

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  11
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  11

Thr Thr Tyr Tyr Arg Tyr Asp Gly Gly Phe Asp Tyr 
1               5                   10          


<210>  12
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  12

Tyr Arg Tyr Asp Gly Gly Phe Asp 
1               5               


<210>  13
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  13

Tyr Tyr Arg Tyr Asp Gly Gly Phe Asp Tyr 
1               5                   10  


<210>  14
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  14

Glu Thr Val Gly Thr Tyr 
1               5       


<210>  15
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  15

Ser Glu Thr Val Gly Thr Tyr 
1               5           


<210>  16
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  16

Lys Ala Ser Glu Thr Val Gly Thr Tyr Val Ser 
1               5                   10      


<210>  17
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  17

Gly Ala Ser 
1           


<210>  18
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  18

Gly Ala Ser Asn Arg Asn Thr 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  19

Gly Gln Ser Tyr Asn Tyr Pro Tyr Thr 
1               5                   


<210>  20
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  20

Ser Tyr Asn Tyr Pro Tyr 
1               5       


<210>  21
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  21

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Met Gly Asn Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile His Pro Gly Ser Gly Gly Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Ala Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Val Ser Gly Thr Val Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  22
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  22

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Phe Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  23
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  23

Gly Asn Thr Phe Thr Asp Tyr Glu 
1               5               


<210>  24
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  24

Gly Asn Thr Phe Thr Asp Tyr 
1               5           


<210>  25
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  25

Asp Tyr Glu Met His 
1               5   


<210>  26
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  26

Ile His Pro Gly Ser Gly Gly Thr 
1               5               


<210>  27
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  27

Pro Gly Ser Gly 
1               


<210>  28
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  28

Ala Ile His Pro Gly Ser Gly Gly Thr Val Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  29

Thr Arg Glu Val Ser Gly Thr Val Tyr 
1               5                   


<210>  30
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  30

Val Ser Gly Thr Val 
1               5   


<210>  31
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  31

Glu Val Ser Gly Thr Val Tyr 
1               5           


<210>  32
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  32

Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10      


<210>  33
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  33

Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10          


<210>  34
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  34

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Phe 
1               5                   10                  15      


<210>  35
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  35

Gln Met Ser 
1           


<210>  36
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  36

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  37
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  37

Ala Gln Asn Leu Glu Leu Pro Trp Thr 
1               5                   


<210>  38
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  38

Asn Leu Glu Leu Pro Trp 
1               5       


<210>  39
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  39

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Ile Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Tyr Tyr Arg Tyr Asp Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  40
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  40

Asp Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Asp Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Leu 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Asn Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Ser Gln Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  41
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  41

Gly Tyr Ser Phe Thr Asn Tyr Trp 
1               5               


<210>  42
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  42

Gly Tyr Ser Phe Thr Asn Tyr 
1               5           


<210>  43
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  43

Asn Tyr Trp Met His 
1               5   


<210>  44
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  44

Ile Tyr Pro Gly Asn Ser Asp Thr 
1               5               


<210>  45
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  45

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Ile Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  46
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  46

Glu Asn Val Asp Thr Tyr 
1               5       


<210>  47
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  47

Ser Glu Asn Val Asp Thr Tyr 
1               5           


<210>  48
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  48

Lys Ala Ser Glu Asn Val Asp Thr Tyr Val Ser 
1               5                   10      


<210>  49
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  49

Gly Gln Ser Tyr Ser Gln Pro Tyr Thr 
1               5                   


<210>  50
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  50

Ser Tyr Ser Gln Pro Tyr 
1               5       


<210>  51
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  51

Gly Gln Ser Tyr Ser Gln Pro Tyr Thr 
1               5                   


<210>  52
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125             


Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys 
    130                 135                 140                 


Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr 
145                 150                 155                 160 


Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu His Pro 
                165                 170                 175     


Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln His 
            180                 185                 190         


His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val 
        195                 200                 205             


Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro Gln Asn 
    210                 215                 220                 


Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr Ala Leu 
225                 230                 235                 240 


Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu Arg Leu 
                245                 250                 255     


Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp 
            260                 265                 270         


Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu Val Leu 
        275                 280                 285             


Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys Arg Ala 
    290                 295                 300                 


Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser Leu Gln 
305                 310                 315                 320 


Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu Leu Gly 
                325                 330                 335     


Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys 
            340                 345                 350         


Val Ile Phe Ile Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro 
        355                 360                 365             


Ala Ala Asp Val Gly Asp Ile Gly Met Lys Asp Ala Asn Thr Ile Arg 
    370                 375                 380                 


Gly Ser Ala Ser Gln Gly Asn Leu Thr Glu Ser Trp Ala Asp Asp Asn 
385                 390                 395                 400 


Pro Arg His His Gly Leu Ala Ala His Ser Ser Gly Glu Glu Arg Glu 
                405                 410                 415     


Ile Gln Tyr Ala Pro Leu Ser Phe His Lys Gly Glu Pro Gln Asp Leu 
            420                 425                 430         


Ser Gly Gln Glu Ala Thr Asn Asn Glu Tyr Ser Glu Ile Lys Ile Pro 
        435                 440                 445             


Lys 
    


<210>  53
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  53

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Val Val Gly Gly Ala 
                325                 330                 335     


Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys Val Ile Phe Val Val 
            340                 345                 350         


Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val Gly 
        355                 360                 365             


Asp Thr Gly Ile Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser Gln 
    370                 375                 380                 


Gly Pro Leu Thr Glu Pro Trp Ala Glu Asp Ser Pro Pro Asp Gln Pro 
385                 390                 395                 400 


Pro Pro Ala Ser Ala Arg Ser Ser Val Gly Glu Gly Glu Leu Gln Tyr 
                405                 410                 415     


Ala Ser Leu Ser Phe Gln Met Val Lys Pro Trp Asp Ser Arg Gly Gln 
            420                 425                 430         


Glu Ala Thr Asp Thr Glu Tyr Ser Glu Ile Lys Ile His Arg 
        435                 440                 445     


<210>  54
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  54

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Gly Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu 
                245                 250                 255     


Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala 
            260                 265                 270         


Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser 
        275                 280                 285             


Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu 
    290                 295                 300                 


Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu 
305                 310                 315                 320 


Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp 
                325                 330                 335     


Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
            340                 345         


<210>  55
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  55

Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
            20                  25                  30          


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
        35                  40                  45              


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
    50                  55                  60                  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
65                  70                  75                  80  


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
                85                  90                  95      


Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr 
            100                 105                 110         


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
        115                 120                 125             


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
    130                 135                 140                 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
145                 150                 155                 160 


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
                165                 170                 175     


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
            180                 185                 190         


Thr Asn Leu Thr Cys Gln Met Lys Arg Gln Gly Ala Gln Val Thr Thr 
        195                 200                 205             


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Thr Ile Thr 
    210                 215                 220                 


Ile Phe Arg Asn Gly Ile Ala Leu Glu Ile Leu Gln Asn Thr Ser Tyr 
225                 230                 235                 240 


Leu Pro Val Leu Glu Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Pro 
                245                 250                 255     


Ser Asn Pro Pro Ala His Leu Ser Trp Phe Gln Gly Ser Pro Ala Leu 
            260                 265                 270         


Asn Ala Thr Pro Ile Ser Asn Thr Gly Ile Leu Glu Leu Arg Arg Val 
        275                 280                 285             


Arg Ser Ala Glu Glu Gly Gly Phe Thr Cys Arg Ala Gln His Pro Leu 
    290                 295                 300                 


Gly Phe Leu Gln Ile Phe Leu Asn Leu Ser Val Tyr Ser Leu Pro Gln 
305                 310                 315                 320 


Leu Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Arg 
                325                 330                 335     


Cys Ser Phe Arg Ala Arg Pro Ala Pro Ser Leu Cys Trp Arg Leu Glu 
            340                 345                 350         


Glu Lys Pro Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Lys Val Asn 
        355                 360                 365             


Ser Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ile Leu His Gly 
    370                 375                 380                 


Gly Leu Ser Ser Asp Leu Lys Val Ser Cys Lys Ala Trp Asn Ile Tyr 
385                 390                 395                 400 


Gly Ser Gln Ser Gly Ser Val Leu Leu Leu Gln Gly Arg Ser Asn Leu 
                405                 410                 415     


Gly Thr Gly Val Val Pro Ala Ala Leu Gly Gly Ala Gly Val Met Ala 
            420                 425                 430         


Leu Leu Cys Ile Cys Leu Cys Leu Ile Phe Phe Leu Ile Val Lys Ala 
        435                 440                 445             


Arg Arg Lys Gln Ala Ala Gly Arg Pro Glu Lys Met Asp Asp Glu Asp 
    450                 455                 460                 


Pro Ile Met Gly Thr Ile Thr Ser Gly Ser Arg Lys Lys Pro Trp Pro 
465                 470                 475                 480 


Asp Ser Pro Gly Asp Gln Ala Ser Pro Pro Gly Asp Ala Pro Pro Leu 
                485                 490                 495     


Glu Glu Gln Lys Glu Leu His Tyr Ala Ser Leu Ser Phe Ser Glu Met 
            500                 505                 510         


Lys Ser Arg Glu Pro Lys Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr 
        515                 520                 525             


Ser Glu Ile Lys Thr Ser Lys 
    530                 535 


<210>  56
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Glu Arg Arg Phe Gln Leu Glu Gly Pro Glu Ser Leu Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Arg Leu Pro Thr Thr Leu Pro 
            20                  25                  30          


Ala Ser Tyr Tyr Gly Tyr Gly Tyr Trp Phe Leu Glu Gly Ala Asp Val 
        35                  40                  45              


Pro Val Ala Thr Asn Asp Pro Asp Glu Glu Val Gln Glu Glu Thr Arg 
    50                  55                  60                  


Gly Arg Phe His Leu Leu Trp Asp Pro Arg Arg Lys Asn Cys Ser Leu 
65                  70                  75                  80  


Ser Ile Arg Asp Ala Arg Arg Arg Asp Asn Ala Ala Tyr Phe Phe Arg 
                85                  90                  95      


Leu Lys Ser Lys Trp Met Lys Tyr Gly Tyr Thr Ser Ser Lys Leu Ser 
            100                 105                 110         


Val Arg Val Met Ala Leu Thr His Arg Pro Asn Ile Ser Ile Pro Gly 
        115                 120                 125             


Thr Leu Glu Ser Gly His Pro Ser Asn Leu Thr Cys Ser Val Pro Trp 
    130                 135                 140                 


Val Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Met Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Ser Leu Gly Pro Arg Thr Thr Gln Ser Ser Val Leu Thr Ile 
                165                 170                 175     


Thr Pro Arg Pro Gln Asp His Ser Thr Asn Leu Thr Cys Gln Val Thr 
            180                 185                 190         


Phe Pro Gly Ala Gly Val Thr Met Glu Arg Thr Ile Gln Leu Asn Val 
        195                 200                 205             


Ser Ser Phe Lys Ile Leu Gln Asn Thr Ser Ser Leu Pro Val Leu Glu 
    210                 215                 220                 


Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Asp Gly Asn Pro Pro Ala 
225                 230                 235                 240 


His Leu Ser Trp Phe Gln Gly Phe Pro Ala Leu Asn Ala Thr Pro Ile 
                245                 250                 255     


Ser Asn Thr Gly Val Leu Glu Leu Pro Gln Val Gly Ser Ala Glu Glu 
            260                 265                 270         


Gly Asp Phe Thr Cys Arg Ala Gln His Pro Leu Gly Ser Leu Gln Ile 
        275                 280                 285             


Ser Leu Ser Leu Phe Val His Trp Lys Pro Glu Gly Arg Ala Gly Gly 
    290                 295                 300                 


Val Leu Gly Ala Val Trp Gly Ala Ser Ile Thr Thr Leu Val Phe Leu 
305                 310                 315                 320 


Cys Val Cys Phe Ile Phe Arg Val Lys Thr Arg Arg Lys Lys Ala Ala 
                325                 330                 335     


Gln Pro Val Gln Asn Thr Asp Asp Val Asn Pro Val Met Val Ser Gly 
            340                 345                 350         


Ser Arg Gly His Gln His Gln Phe Gln Thr Gly Ile Val Ser Asp His 
        355                 360                 365             


Pro Ala Glu Ala Gly Pro Ile Ser Glu Asp Glu Gln Glu Leu His Tyr 
    370                 375                 380                 


Ala Val Leu His Phe His Lys Val Gln Pro Gln Glu Pro Lys Val Thr 
385                 390                 395                 400 


Asp Thr Glu Tyr Ser Glu Ile Lys Ile His Lys 
                405                 410     


<210>  57
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Glu Gly Asp Arg Gln Tyr Gly Asp Gly Tyr Leu Leu Gln Val Gln 
1               5                   10                  15      


Glu Leu Val Thr Val Gln Glu Gly Leu Cys Val His Val Pro Cys Ser 
            20                  25                  30          


Phe Ser Tyr Pro Gln Asp Gly Trp Thr Asp Ser Asp Pro Val His Gly 
        35                  40                  45              


Tyr Trp Phe Arg Ala Gly Asp Arg Pro Tyr Gln Asp Ala Pro Val Ala 
    50                  55                  60                  


Thr Asn Asn Pro Asp Arg Glu Val Gln Ala Glu Thr Gln Gly Arg Phe 
65                  70                  75                  80  


Gln Leu Leu Gly Asp Ile Trp Ser Asn Asp Cys Ser Leu Ser Ile Arg 
                85                  90                  95      


Asp Ala Arg Lys Arg Asp Lys Gly Ser Tyr Phe Phe Arg Leu Glu Arg 
            100                 105                 110         


Gly Ser Met Lys Trp Ser Tyr Lys Ser Gln Leu Asn Tyr Lys Thr Lys 
        115                 120                 125             


Gln Leu Ser Val Phe Val Thr Ala Leu Thr His Arg Pro Asp Ile Leu 
    130                 135                 140                 


Ile Leu Gly Thr Leu Glu Ser Gly His Ser Arg Asn Leu Thr Cys Ser 
145                 150                 155                 160 


Val Pro Trp Ala Cys Lys Gln Gly Thr Pro Pro Met Ile Ser Trp Ile 
                165                 170                 175     


Gly Ala Ser Val Ser Ser Pro Gly Pro Thr Thr Ala Arg Ser Ser Val 
            180                 185                 190         


Leu Thr Leu Thr Pro Lys Pro Gln Asp His Gly Thr Ser Leu Thr Cys 
        195                 200                 205             


Gln Val Thr Leu Pro Gly Thr Gly Val Thr Thr Thr Ser Thr Val Arg 
    210                 215                 220                 


Leu Asp Val Ser Tyr Pro Pro Trp Asn Leu Thr Met Thr Val Phe Gln 
225                 230                 235                 240 


Gly Asp Ala Thr Ala Ser Thr Ala Leu Gly Asn Gly Ser Ser Leu Ser 
                245                 250                 255     


Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asn Ser Asn 
            260                 265                 270         


Pro Pro Ala Arg Leu Ser Trp Thr Arg Gly Ser Leu Thr Leu Cys Pro 
        275                 280                 285             


Ser Arg Ser Ser Asn Pro Gly Leu Leu Glu Leu Pro Arg Val His Val 
    290                 295                 300                 


Arg Asp Glu Gly Glu Phe Thr Cys Arg Ala Gln Asn Ala Gln Gly Ser 
305                 310                 315                 320 


Gln His Ile Ser Leu Ser Leu Ser Leu Gln Asn Glu Gly Thr Gly Thr 
                325                 330                 335     


Ser Arg Pro Val Ser Gln Val Thr Leu Ala Ala Val Gly Gly Ala Gly 
            340                 345                 350         


Ala Thr Ala Leu Ala Phe Leu Ser Phe Cys Ile Ile Phe Ile Ile Val 
        355                 360                 365             


Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val Gly Asp 
    370                 375                 380                 


Thr Gly Met Glu Asp Ala Lys Ala Ile Arg Gly Ser Ala Ser Gln Gly 
385                 390                 395                 400 


Pro Leu Thr Glu Ser Trp Lys Asp Gly Asn Pro Leu Lys Lys Pro Pro 
                405                 410                 415     


Pro Ala Val Ala Pro Ser Ser Gly Glu Glu Gly Glu Leu His Tyr Ala 
            420                 425                 430         


Thr Leu Ser Phe His Lys Val Lys Pro Gln Asp Pro Gln Gly Gln Glu 
        435                 440                 445             


Ala Thr Asp Ser Glu Tyr Ser Glu Ile Lys Ile His Lys Arg Glu Thr 
    450                 455                 460                 


Ala Glu Thr Gln Ala Cys Leu Arg Asn His Asn Pro Ser Ser Lys Glu 
465                 470                 475                 480 


Val Arg Gly 
            


<210>  58
<211>  681
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro 
1               5                   10                  15      


Glu Gly Leu Cys Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln 
            20                  25                  30          


Asp Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val 
        35                  40                  45              


Thr Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg 
    50                  55                  60                  


Glu Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro 
65                  70                  75                  80  


Ala Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp 
                85                  90                  95      


Glu Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr 
            100                 105                 110         


Asn Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln 
        115                 120                 125             


Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val 
    130                 135                 140                 


Thr Val Ile Cys Val Phe Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro 
145                 150                 155                 160 


Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro 
                165                 170                 175     


Thr Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Arg Pro Gln Asp 
            180                 185                 190         


His Asn Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val 
        195                 200                 205             


Ser Val Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp 
    210                 215                 220                 


Leu Val Ile Ser Ile Ser Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln 
225                 230                 235                 240 


Pro Gln Gly Asn Val Pro Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu 
                245                 250                 255     


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
            260                 265                 270         


Val Leu Gln Asn Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
        275                 280                 285             


Pro Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg 
    290                 295                 300                 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu 
305                 310                 315                 320 


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
                325                 330                 335     


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
            340                 345                 350         


Pro Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val Thr His Ser 
        355                 360                 365             


Ser Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln Val Leu Ser 
    370                 375                 380                 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln 
385                 390                 395                 400 


Val Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly 
                405                 410                 415     


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Ser Pro Lys Leu 
            420                 425                 430         


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
        435                 440                 445             


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
    450                 455                 460                 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Asp Ser Phe Glu Val Thr Pro 
465                 470                 475                 480 


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
                485                 490                 495     


Leu Ser Ser Gly Leu Arg Leu Arg Cys Glu Ala Trp Asn Val His Gly 
            500                 505                 510         


Ala Gln Ser Gly Ser Ile Leu Gln Leu Pro Asp Lys Lys Gly Leu Ile 
        515                 520                 525             


Ser Thr Ala Phe Ser Asn Gly Ala Phe Leu Gly Ile Gly Ile Thr Ala 
    530                 535                 540                 


Leu Leu Phe Leu Cys Leu Ala Leu Ile Ile Met Lys Ile Leu Pro Lys 
545                 550                 555                 560 


Arg Arg Thr Gln Thr Glu Thr Pro Arg Pro Arg Phe Ser Arg His Ser 
                565                 570                 575     


Thr Ile Leu Asp Tyr Ile Asn Val Val Pro Thr Ala Gly Pro Leu Ala 
            580                 585                 590         


Gln Lys Arg Asn Gln Lys Ala Thr Pro Asn Ser Pro Arg Thr Pro Leu 
        595                 600                 605             


Pro Pro Gly Ala Pro Ser Pro Glu Ser Lys Lys Asn Gln Lys Lys Gln 
    610                 615                 620                 


Tyr Gln Leu Pro Ser Phe Pro Glu Pro Lys Ser Ser Thr Gln Ala Pro 
625                 630                 635                 640 


Glu Ser Gln Glu Ser Gln Glu Glu Leu His Tyr Ala Thr Leu Asn Phe 
                645                 650                 655     


Pro Gly Val Arg Pro Arg Pro Glu Ala Arg Met Pro Lys Gly Thr Gln 
            660                 665                 670         


Ala Asp Tyr Ala Glu Val Lys Phe Gln 
        675                 680     


<210>  59
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  59

Asn Lys Asp Pro Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro Val 
1               5                   10                  15      


Pro Glu Gly Leu Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro Arg 
            20                  25                  30          


Asp Gly Trp Asp Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys Gly 
        35                  40                  45              


Arg Thr Ser Pro Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln Ser 
    50                  55                  60                  


Arg Glu Val Glu Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly Asp 
65                  70                  75                  80  


Pro Gly Lys Gly Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg Glu 
                85                  90                  95      


Asp Glu Ala Trp Tyr Phe Phe Arg Val Glu Arg Gly Ser Arg Val Arg 
            100                 105                 110         


His Ser Phe Leu Ser Asn Ala Phe Phe Leu Lys Val Thr Ala Leu Thr 
        115                 120                 125             


Lys Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro 
    130                 135                 140                 


Val Thr Val Ile Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro Ala 
145                 150                 155                 160 


Pro Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr Arg 
                165                 170                 175     


Pro Ser Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro Gln 
            180                 185                 190         


Asp His Asp Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly 
        195                 200                 205             


Val Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Lys 
    210                 215                 220                 


Asp Leu Ile Ile Ser Ile Ser His Asp Asn Thr Ser Ala Leu Glu Leu 
225                 230                 235                 240 


Gln Gly Asn Val Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu Arg 
                245                 250                 255     


Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp Val 
            260                 265                 270         


Leu Gln Asp Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg Thr 
        275                 280                 285             


Leu Gly Leu Glu Leu Arg Gly Val Arg Ala Gly Asp Ser Gly Arg Tyr 
    290                 295                 300                 


Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Gln Ala Leu Asp 
305                 310                 315                 320 


Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln 
                325                 330                 335     


Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu Pro 
            340                 345                 350         


Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Val Thr His Ser Ser 
        355                 360                 365             


Pro Pro Ala Arg Leu Ser Trp Thr Arg Trp Gly Gln Thr Val Gly Pro 
    370                 375                 380                 


Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Pro Ile Gln Met 
385                 390                 395                 400 


Glu His Glu Gly Glu Phe Thr Cys His Ala Gln His Pro Leu Gly Ser 
                405                 410                 415     


Gln His Val Ser Leu Ser Leu Ser Val His Tyr Pro Pro Gln Leu Leu 
            420                 425                 430         


Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys Ser 
        435                 440                 445             


Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu Glu 
    450                 455                 460                 


Leu Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Glu Val Thr Pro Ser 
465                 470                 475                 480 


Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly Leu 
                485                 490                 495     


Ser Ser Gly Leu Arg Leu Arg Cys Lys Ala Trp Asn Val His Gly Ala 
            500                 505                 510         


Gln Ser Gly Ser Val Phe Gln Leu Leu Pro Gly Lys Leu Glu His Gly 
        515                 520                 525             


Gly Gly Leu Gly Leu Gly Ala Ala Leu Gly Ala Gly Val Ala Ala Leu 
    530                 535                 540                 


Leu Ala Phe Cys Ser Cys Leu Val Val Phe Arg Val Lys Ile Cys Arg 
545                 550                 555                 560 


Lys Glu Ala Arg Lys Arg Ala Ala Ala Glu Gln Asp Val Pro Ser Thr 
                565                 570                 575     


Leu Gly Pro Ile Ser Gln Gly His Gln His Glu Cys Ser Ala Gly Ser 
            580                 585                 590         


Ser Gln Asp His Pro Pro Pro Gly Ala Ala Thr Tyr Thr Pro Gly Lys 
        595                 600                 605             


Gly Glu Glu Gln Glu Leu His Tyr Ala Ser Leu Ser Phe Gln Gly Leu 
    610                 615                 620                 


Arg Leu Trp Glu Pro Ala Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr 
625                 630                 635                 640 


Ser Glu Ile Lys Ile His Thr Gly Gln Pro Leu Arg Gly Pro Gly Phe 
                645                 650                 655     


Gly Leu Gln Leu Glu Arg Glu Met Ser Gly Met Val Pro Lys 
            660                 665                 670 


<210>  60
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  60

Lys Glu Gln Lys Asp Tyr Leu Leu Thr Met Gln Lys Ser Val Thr Val 
1               5                   10                  15      


Gln Glu Gly Leu Cys Val Ser Val Leu Cys Ser Phe Ser Tyr Pro Gln 
            20                  25                  30          


Asn Gly Trp Thr Ala Ser Asp Pro Val His Gly Tyr Trp Phe Arg Ala 
        35                  40                  45              


Gly Asp His Val Ser Arg Asn Ile Pro Val Ala Thr Asn Asn Pro Ala 
    50                  55                  60                  


Arg Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 
65                  70                  75                  80  


Pro Gln Asn Lys Asp Cys Thr Leu Ser Ile Arg Asp Thr Arg Glu Ser 
                85                  90                  95      


Asp Ala Gly Thr Tyr Val Phe Cys Val Glu Arg Gly Asn Met Lys Trp 
            100                 105                 110         


Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Ser Gln Asp 
        115                 120                 125             


Leu Leu Ser Arg Tyr Arg Leu Glu Val Pro Glu Ser Val Thr Val Gln 
    130                 135                 140                 


Glu Gly Leu Cys Val Ser Val Pro Cys Ser Val Leu Tyr Pro His Tyr 
145                 150                 155                 160 


Asn Trp Thr Ala Ser Ser Pro Val Tyr Gly Ser Trp Phe Lys Glu Gly 
                165                 170                 175     


Ala Asp Ile Pro Trp Asp Ile Pro Val Ala Thr Asn Thr Pro Ser Gly 
            180                 185                 190         


Lys Val Gln Glu Asp Thr His Gly Arg Phe Leu Leu Leu Gly Asp Pro 
        195                 200                 205             


Gln Thr Asn Asn Cys Ser Leu Ser Ile Arg Asp Ala Arg Lys Gly Asp 
    210                 215                 220                 


Ser Gly Lys Tyr Tyr Phe Gln Val Glu Arg Gly Ser Arg Lys Trp Asn 
225                 230                 235                 240 


Tyr Ile Tyr Asp Lys Leu Ser Val His Val Thr Ala Leu Thr His Met 
                245                 250                 255     


Pro Thr Phe Ser Ile Pro Gly Thr Leu Glu Ser Gly His Pro Arg Asn 
            260                 265                 270         


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Thr 
        275                 280                 285             


Ile Thr Trp Met Gly Ala Ser Val Ser Ser Leu Asp Pro Thr Ile Thr 
    290                 295                 300                 


Arg Ser Ser Met Leu Ser Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
305                 310                 315                 320 


Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val Thr Met Thr 
                325                 330                 335     


Arg Ala Val Arg Leu Asn Ile Ser Tyr Pro Pro Gln Asn Leu Thr Met 
            340                 345                 350         


Thr Val Phe Gln Gly Asp Gly Thr Ala Ser Thr Thr Leu Arg Asn Gly 
        355                 360                 365             


Ser Ala Leu Ser Val Leu Glu Gly Gln Ser Leu His Leu Val Cys Ala 
    370                 375                 380                 


Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp Gly Ser Leu 
385                 390                 395                 400 


Thr Leu Ser Pro Ser Gln Ser Ser Asn Leu Gly Val Leu Glu Leu Pro 
                405                 410                 415     


Arg Val His Val Lys Asp Glu Gly Glu Phe Thr Cys Arg Ala Gln Asn 
            420                 425                 430         


Pro Leu Gly Ser Gln His Ile Ser Leu Ser Leu Ser Leu Gln Asn Glu 
        435                 440                 445             


Tyr Thr Gly Lys Met Arg Pro Ile Ser Gly Val Thr Leu Gly Ala Phe 
    450                 455                 460                 


Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Tyr Phe Cys Ile Ile 
465                 470                 475                 480 


Phe Val Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Val 
                485                 490                 495     


Gly Val Gly Asp Thr Gly Met Glu Asp Ala Asn Ala Val Arg Gly Ser 
            500                 505                 510         


Ala Ser Gln Gly Pro Leu Ile Glu Ser Pro Ala Asp Asp Ser Pro Pro 
        515                 520                 525             


His His Ala Pro Pro Ala Leu Ala Thr Pro Ser Pro Glu Glu Gly Glu 
    530                 535                 540                 


Ile Gln Tyr Ala Ser Leu Ser Phe His Lys Ala Arg Pro Gln Tyr Pro 
545                 550                 555                 560 


Gln Glu Gln Glu Ala Ile Gly Tyr Glu Tyr Ser Glu Ile Asn Ile Pro 
                565                 570                 575     


Lys 
    


